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immunotherapies for food allergy

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https://www.readbyqxmd.com/read/29769472/-evaluation-of-the-effectiveness-of-subcutaneous-immunotherapy-using-birch-pollen-extract-for-pollen-food-allergy-syndrome
#1
Shuntaro Tsumagari, Satomi Mori, Hiroko Ishizu, Yutaka Tanaka, Yoshihisa Okamoto, Kazuyuki Kurihara
BACKGROUNDS: Recently, patients with oral allergy syndrome (OAS) to fruits or vegetables caused by pollenfood allergy syndrome (PFAS) have increased nationwide. We examined effectiveness of SCIT using birch pollen extract for PFAS. METHODS: A total of 19 patients (9 male and 10 female) underwent SCIT with birch pollen extract from August 2011 to August 2016. Rush schedule was used for the initial updosing for SCIT in a hospital setting. In maintenance phase, SCIT was administered every 4-8 weeks on an outpatient basis...
2018: Arerugī, [Allergy]
https://www.readbyqxmd.com/read/29754191/the-unique-molecular-signatures-of-contact-dermatitis-and-implications-for-treatment
#2
REVIEW
Alexandra Leonard, Emma Guttman-Yassky
Irritant contact dermatitis (ICD) and allergic contact dermatitis (ACD) are common skin disorders that are characterized by inflammation, oozing, crusting, and pruritus. Atopic dermatitis (AD) is an inflammatory skin disease characterized by immune and barrier abnormalities and is additionally a risk factor for acquiring ICD and ACD. New work on allergic sensitization to common allergens (e.g., nickel and fragrance) in human skin has shown that different allergens have distinct molecular fingerprinting. For example, nickel promotes strong Th1/Th17 polarization, whereas fragrance allergy causes Th2/Th22 skewing, which is similar to the phenotype of AD...
May 12, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29732290/novel-strategies-in-immunotherapy-for-allergic-diseases
#3
REVIEW
Mohana Rajakulendran, Elizabeth Huiwen Tham, Jian Yi Soh, H P Van Bever
Conventional immunotherapy (IT) for optimal control of respiratory and food allergies has been fraught with concerns of efficacy, safety, and tolerability. The development of adjuvants to conventional IT has potentially increased the effectiveness and safety of allergen IT, which may translate into improved clinical outcomes and sustained unresponsiveness even after cessation of therapy. Novel strategies incorporating the successful use of adjuvants such as allergoids, immunostimulatory DNA sequences, monoclonal antibodies, carriers, recombinant proteins, and probiotics have now been described in clinical and murine studies...
April 2018: Asia Pacific Allergy
https://www.readbyqxmd.com/read/29700872/oral-immunotherapy-with-omalizumab-reverses-the-th2-cell-like-program-of-regulatory-t-cells-and-restores-their-function
#4
Azza Abdel-Gadir, Lynda Schneider, Arianna Casini, Louis-Marie Charbonnier, Sara V Little, Timothy Harrington, Dale T Umetsu, Rima Rachid, Talal A Chatila
BACKGROUND: Oral immunotherapy (OIT) successfully desensitizes patients with food allergies, but the immune mechanisms mediating its efficacy remain obscure. OBJECTIVES: We tested the hypothesis that allergen-specific regulatory T (Treg) cell function is impaired in food allergy and is restored by anti-IgE antibody (omalizumab)-supplemented OIT. METHODS: Peanut-specific T effector (Teff) and Treg cell proliferative responses, activation markers and cytokine expression were analyzed by flow cytometry in 13 peanut allergic subjects before the start of omalizumab- supplemented OIT and periodically in some subjects thereafter for up to two years...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29700869/tree-nut-allergies-allergen-homology-cross-reactivity-and-implications-for-therapy
#5
Johanna M Smeekens, Kenneth Bagley, Michael Kulis
Tree nut allergy is a potentially life-threatening disease that is increasing in prevalence, now affecting 1% of the general population in the United States. While other food allergies often resolve spontaneously, tree nut allergies are outgrown in less than 10% of cases. Due to the likelihood of cross-sensitization to multiple tree nut allergens, the current treatment guideline is strict avoidance of all nuts once one tree nut allergy has been diagnosed. For example, walnut and pecan are highly cross-reactive, along with cashew and pistachio, but the extent of clinical, IgE-mediated cross-reactivity among other tree nuts remains unclear, therefore making avoidance of all tree nuts a safe approach...
April 27, 2018: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29676439/oral-and-sublingual-immunotherapy-for-egg-allergy
#6
REVIEW
Olga Romantsik, Maria Angela Tosca, Simona Zappettini, Maria Grazia Calevo
BACKGROUND: Clinical egg allergy is a common food allergy. Current management relies upon strict allergen avoidance. Oral immunotherapy might be an optional treatment, through desensitization to egg allergen. OBJECTIVES: To determine the efficacy and safety of oral and sublingual immunotherapy in children and adults with immunoglobulin E (IgE)-mediated egg allergy as compared to a placebo treatment or an avoidance strategy. SEARCH METHODS: We searched 13 databases for journal articles, conference proceedings, theses and trials registers using a combination of subject headings and text words (last search 31 March 2017)...
April 20, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29676066/allergen-specific-immunotherapies-for-food-allergy
#7
REVIEW
Elizabeth Feuille, Anna Nowak-Wegrzyn
With rising prevalence of food allergy (FA), allergen-specific immunotherapy (AIT) for FA has become an active area of research in recent years. In AIT, incrementally increasing doses of inciting allergen are given with the goal to increase tolerance, initially through desensitization, which relies on regular exposure to allergen. With prolonged therapy in some subjects, AIT may induce sustained unresponsiveness, in which tolerance is retained after a period of allergen avoidance. Methods of AIT currently under study in humans include oral, sublingual, epicutaneous, and subcutaneous delivery of modified allergenic protein, as well as via DNA-based vaccines encoding allergen with lysosomal-associated membrane protein I...
May 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29675865/allergen-immunotherapy-in-people-dogs-cats-and-horses-differences-similarities-and-research-needs
#8
R S Mueller, E Jensen-Jarolim, F Roth-Walter, E Marti, J Janda, A A Seida, D DeBoer
In human patients with seasonal allergic rhinoconjunctivitis sensitized to grass pollen, the first successful allergen immunotherapy (AIT) was reported in 1911. Today, immunotherapy is an accepted treatment for allergic asthma, allergic rhinitis and hypersensitivities to insect venom. AIT is also used for atopic dermatitis and recently for food allergy. Subcutaneous, epicutaneous, intralymphatic, oral and sublingual protocols of AIT exist. In animals, most data are available in dogs where subcutaneous AIT is an accepted treatment for atopic dermatitis...
April 19, 2018: Allergy
https://www.readbyqxmd.com/read/29656306/oral-and-sublingual-immunotherapy-for-treatment-of-ige-mediated-food-allergy
#9
REVIEW
Amy M Scurlock
Development of active therapies for IgE-mediated food allergy is a critical action step toward alleviating the adverse medical, psychosocial, and economic burdens on affected patients and families. Significant progress has been observed specifically in the application of single-allergen oral and sublingual immunotherapy for treatment of IgE-mediated food allergy, with emphasis on milk, egg, and peanut as the primary allergens. Oral immunotherapy (OIT) has demonstrated efficacy in promoting immunomodulatory effects that lead to the clinical outcome of desensitization, defined as reduced reactivity while on active OIT, in the majority of treated individuals; however, achievement of sustained unresponsiveness following cessation of therapy has been observed in a smaller subset of treated subjects...
April 14, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29655584/nanoemulsion-adjuvant-driven-redirection-of-t-h-2-immunity-inhibits-allergic-reactions-in-murine-models-of-peanut-allergy
#10
Jessica J O'Konek, Jeffrey J Landers, Katarzyna W Janczak, Rishi R Goel, Anna M Mondrusov, Pamela T Wong, James R Baker
BACKGROUND: Immunotherapy for food allergies involves progressive increased exposures to food that result in desensitization to food allergens in some subjects but not tolerance to the food. Therefore new approaches to suppress allergic immunity to food are necessary. Previously, we demonstrated that intranasal immunization with a nanoemulsion (NE) adjuvant induces robust mucosal antibody and TH 17-polarized immunity, as well as systemic TH 1-biased cellular immunity with suppression of pre-existing TH 2-biased immunity...
April 11, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629956/what-you-should-not-miss-from-the-systematic-reviews-and-meta-analyses-on-allergen-specific-immunotherapy-in-2017
#11
Désirée Larenas-Linnemann, Jorge A Luna-Pech
PURPOSE OF REVIEW: Allergen immunotherapy (AIT) is a well recognized and extensively studied therapeutic intervention for some allergic diseases. Every year new systematic reviews and meta-analysis provide the most powerful source of evidence to orient decision making on prevention or efficacy of AIT. We here discuss systematic reviews and meta-analyses on AIT (published January 2017 to February 2018). RECENT FINDINGS: We identified 4 systematic reviews and 10 meta-analyses...
June 2018: Current Opinion in Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29629055/accuracy-of-immunoblotting-assay-for-detection-of-specific-ige-compared-with-immunocap-in-allergic-patients
#12
Raheleh Shokouhi Shoormasti, Mohammad Reza Fazlollahi, Anoshirvan Kazemnejad, Masoud Movahedi, Behnoosh Tayebi, Zahra Yazdanyar, Zakieh Azadi, Zahra Pourpak, Mostafa Moin
Background and aim: Standardized techniques help us to better diagnosis and follow up of allergic diseases. In this study, we determined the sensitivity, accuracy, and specificity of an Immunoblotting test compared to ImmunoCAP as the reference in vitro test for detection of specific IgE in allergic patients. Methods: In this cross-sectional study, specific IgE level was determined in patients with allergic symptoms who referred to the Immunology, Asthma and Allergy Research Institute, Tehran, Iran from 2010-2016, by two techniques...
February 2018: Electronic Physician
https://www.readbyqxmd.com/read/29617351/the-nuts-and-bolts-of-food-immunotherapy-the-future-of-food-allergy
#13
REVIEW
Sara Anvari, Katherine Anagnostou
Food allergies are on the rise and have a major impact on the quality of life of the food allergic child and their family. Currently, the mainstream treatment for food allergies is strict avoidance and elimination of the allergenic food(s) from the patient's diet in order to prevent an allergic reaction. However, recent advances in research have presented new therapeutic options for food allergic patients that are potentially becoming promising alternatives to traditional treatment. Food immunotherapy is the most popular of these new emerging interventions and has been studied intensively over the last decade for various foods...
April 4, 2018: Children
https://www.readbyqxmd.com/read/29603410/low-dose-oral-immunotherapy-for-children-with-anaphylactic-peanut-allergy-in-japan
#14
Ken-Ichi Nagakura, Noriyuki Yanagida, Sakura Sato, Makoto Nishino, Tomoyuki Asaumi, Kiyotake Ogura, Motohiro Ebisawa
BACKGROUND: Oral immunotherapy (OIT) is a promising treatment for persons with allergy; however, it can also cause adverse allergic reactions. In this study, we investigated the efficacy of low-dose OIT for anaphylactic peanut allergy. METHODS: Twenty-four children (median age, 9.6 years) with anaphylaxis to peanuts were hospitalized for 5 days and then gradually fed increasing amounts of peanut powder up to 133 mg/day. One year later, they underwent an oral food challenge after 2 weeks of peanut avoidance...
March 30, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29588872/preventing-peanut-allergy
#15
REVIEW
Meng Chen, Michael Welch, Susan Laubach
The rising prevalence of food allergy and specifically peanut allergy has had significant implications for affected patients, families, and society. The current standard of care remains strict avoidance and the use of emergency medications for accidental ingestions. There is recent evidence-based information to suggest that one approach to preventing peanut allergy lies in early introduction of peanut. This represents a paradigm shift from previous recommendations and has led to updated guidelines in the United States, Europe, and Australasia on the introduction of potentially allergenic foods in the infant diet...
March 1, 2018: Pediatric Allergy, Immunology, and Pulmonology
https://www.readbyqxmd.com/read/29540279/one-child-s-food-fight-a-case-study-of-oral-immunotherapy-treatment-for-food-allergies
#16
Jessica L Peck, E Katherine Larson, Stacy K Silvers
The prevalence of food allergy has risen dramatically in the last two decades. Primary care providers encounter food-allergic children on a daily basis. Although the standard of care has traditionally been strict avoidance of the allergen and advisement to carry an epinephrine autoinjector in case of an accidental exposure resulting in a severe reaction, food allergy research has progressed in the past decade concerning various immunotherapies that may provide an alternate treatment strategy. Oral immunotherapy (OIT), performed under the supervision of an allergist, is the most widely studied of these therapies...
March 12, 2018: Journal of Pediatric Health Care
https://www.readbyqxmd.com/read/29528585/food-specific-ige-as-a-biomarker-of-oral-immunotherapy-efficacy-in-comparison-to-double-blind-food-challenge-test
#17
Nissreen E ELBadawy, Randa S Abdel-Latif
Specific immunotherapy (SIT) is one of the important lines for the treatment of food allergy. Efficacy tests for clinical response to SIT are limited and subjective. In this study, we aimed to evaluate the validity of food specific Ig E levels as a biomarker of clinical improvement in children with food allergy treated with oral immunotherapy (OIT). We analysed 184 children with food allergy, 143 had undergone 2 years of food OIT and 41 were on allergen restricted diet and considered as control. All patients were subjected to Double-Blind Placebo-Controlled Food Challenge test (DBPCFC), allergic symptom score calculation, and serum food specific Ig E level before and after oral immunotherapy for treated patients and after 2 year of allergen restricted diet for the control group...
June 2017: Egyptian Journal of Immunology
https://www.readbyqxmd.com/read/29524535/advances-in-the-approach-to-the-patient-with-food-allergy
#18
Amy M Scurlock, Stacie M Jones
Advances in food allergy diagnosis, management, prevention, and therapeutic interventions have been significant over the past 2 decades. Evidence-based national and international guidelines have streamlined food allergy diagnosis and management, whereas paradigm-shifting work in primary prevention of peanut allergy has resulted in significant modifications in the approach to early food introduction in infants and toddlers. Innovative investigation of food allergy epidemiology, systems biology, effect, and management has provided important insights...
March 8, 2018: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29516263/the-impact-of-baked-egg-and-baked-milk-diets-on-ige-and-non-ige-mediated-allergy
#19
REVIEW
Julia Upton, Anna Nowak-Wegrzyn
Baked milk (BM) and baked egg (BE) diets are increasingly used in the management of milk and egg allergy, rather than avoidance. Children with tolerance versus reactivity to BM and BE may have smaller skin prick test and lower specific IgE, and BM-tolerant children have less basophil reactivity and more peripheral T regulatory cells. However, most milk- and egg-allergic children tolerate BM and BE and an individual's reactivity is unpredictable. Non-reactivity is due to conformational changes in the allergens...
March 8, 2018: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/29488131/mechanisms-of-oral-tolerance
#20
REVIEW
Leticia Tordesillas, M Cecilia Berin
Oral tolerance is a state of systemic unresponsiveness that is the default response to food antigens in the gastrointestinal tract, although immune tolerance can also be induced by other routes, such as the skin or inhalation. Antigen can be acquired directly by intestinal phagocytes, or pass through enterocytes or goblet cell-associated passages prior to capture by dendritic cells (DCs) in the lamina propria. Mucin from goblet cells acts on DCs to render them more tolerogenic. A subset of regulatory DCs expressing CD103 is responsible for delivery of antigen to the draining lymph node and induction of Tregs...
February 27, 2018: Clinical Reviews in Allergy & Immunology
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