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https://www.readbyqxmd.com/read/29443752/the-first-case-report-of-enterococcus-gallinarum-meningitis-in-neonate-a-literature-review
#1
Xiaoquan Li, Shujuan Fan, Xiaojie Lin, Li Liu, Jie Zheng, Xihui Zhou, Axel Heep
RATIONALE: Enterococcus gallinarum meningitis (EGM) is rarely found in normal adults and even rarer in children. To our knowledge, EGM in neonate has not been reported previously. PATIENTS CONCERNS: Here we reported the first case of EGM in neonate. Prolonged fever was the only manifestation for the case after admission. DIAGNOSES: Cerebrospinal fluid cultures showed that the isolate was Enterococcus gallinarum and sensitive to linezolid. INTERVENTIONS: Ceftriaxone, beta lactam type, and vancomycin were used respectively, but not effective...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29432383/safety-and-immunogenicity-of-seven-dosing-regimens-of-the-candidate-rts-s-as01e-malaria-vaccine-integrated-within-an-expanded-program-on-immunization-regimen-a-phase-ii-single-center-open-controlled-trial-in-infants-in-malawi
#2
Desiree Witte, Nigel A Cunliffe, Ann M Turner, Edward Ngulube, Opokua Ofori-Anyinam, Johan Vekemans, Philips Chimpeni, Marc Lievens, Trevor P Wilson, Jenala Njiramʼmadzi, Yolanda Guerra Mendoza, Amanda Leach
BACKGROUND: In a phase III trial, the RTS,S/AS01 malaria vaccine produced lower anti-circumsporozoite (CS) antibody titres when co-administered with Expanded Programme on Immunisation (EPI) vaccines (0,1,2-month schedule) at 6-12 weeks compared to 5-17 months at first vaccination. Alternative infant immunisation schedules within the EPI were investigated. METHODS: This phase II, open, single site (Blantyre, Malawi) trial was conducted in infants aged 1-7 days. Subjects were equally randomised across seven groups to receive three doses of RTS,S/AS01E at time points that included ≤7 days, 6, 10, 14, 26 weeks, and 9 months...
February 9, 2018: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29428916/clinical-profile-of-neonates-with-hypernatremic-dehydration-hospitalized-in-an-outborn-neonatal-intensive-care-unit
#3
Smita Nair, Amitabh Singh, Mamta Jajoo
This retrospective observational study aimed to find the clinical profile of hypernatremic dehydration in neonates. 49 neonates (3.4% of the total admitted newborns) developed hypernatremic dehydration. The major presenting complaints were fever (34.6%), poor feeding (42.8%), loose stools (40.8%) and lethargy (26.5%). The time needed for correction of hypernatremia was 38.6 (±15.1) hours. Exclusively breastfed neonates had lesser complication rates of hypernatremic dehydration.
February 9, 2018: Indian Pediatrics
https://www.readbyqxmd.com/read/29408748/comparison-of-outcomes-between-induction-of-labor-and-spontaneous-labor-for-term-breech-a-systemic-review-and-meta-analysis
#4
REVIEW
Wen Sun, Fen Liu, Shiliang Liu, Sara-Michelle Gratton, Darine El-Chaar, Shi Wu Wen, Dunjin Chen
OBJECTIVES: Few studies have assessed the impact of induction of labor on breech presentation. This study aims to summarize the effect of induction of labor of breech presentation on perinatal morbidity. METHODS: Literature review was done in Medline, Embase, Web of science and Cochrane Library up to 20 October 2017. Randomized control studies, cohort studies, and case control publishing studies comparing induction of labor versus spontaneous labor of singleton live breech birth were included...
December 16, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29406479/application-of-the-rochester-criteria-to-identify-febrile-infants-with-bacteremia-and-meningitis
#5
Paul L Aronson, Russell J McCulloh, Joel S Tieder, Lise E Nigrovic, Rianna C Leazer, Elizabeth R Alpern, Elana A Feldman, Fran Balamuth, Whitney L Browning, Mark I Neuman
OBJECTIVES: The Rochester criteria were developed to identify febrile infants aged 60 days or younger at low-risk of bacterial infection and do not include cerebrospinal fluid (CSF) testing. Prior studies have not specifically assessed criteria performance for bacteremia and bacterial meningitis (invasive bacterial infection). Our objective was to determine the sensitivity of the Rochester criteria for detection of invasive bacterial infection. METHODS: Retrospective cohort study of febrile infants aged 60 days or younger with invasive bacterial infections evaluated at 8 pediatric emergency departments from July 1, 2012, to June 30, 2014...
February 5, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29388196/vaccines-for-preventing-influenza-in-healthy-adults
#6
REVIEW
Vittorio Demicheli, Tom Jefferson, Eliana Ferroni, Alessandro Rivetti, Carlo Di Pietrantonj
BACKGROUND: The consequences of influenza in adults are mainly time off work. Vaccination of pregnant women is recommended internationally. This is an update of a review published in 2014. Future updates of this review will be made only when new trials or vaccines become available. Observational data included in previous versions of the review have been retained for historical reasons but have not been updated due to their lack of influence on the review conclusions. OBJECTIVES: To assess the effects (efficacy, effectiveness, and harm) of vaccines against influenza in healthy adults, including pregnant women...
February 1, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29381934/pregnancy-associated-hemophagocytic-lymphohistiocytosis-secondary-to-nk-t-cells-lymphoma-a-case-report-and-literature-review
#7
Mengzhou He, Jing Jia, Jingyi Zhang, Rajluxmee Beejadhursing, Lali Mwamaka Sharifu, Jun Yu, Shaoshuai Wang, Ling Feng
RATIONALE: Hemophagocytic lymphohistiocytosis (HLH) occurs primarily in pediatric population, or secondary to malignancy, infection, or autoimmune disease. This disease is rare and prognosis is generally poor. Only a small number of cases during pregnancy have been reported in literature. PATIENT CONCERNS: We report a case of pregnancy-associated HLH secondary to natural killer (NK)/T cells lymphoma. She was admitted at 30 weeks and 3 days of pregnancy with complaints of abdominal pain and fever as high as 39...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29344471/a-6-month-old-girl-with-incontinentia-pigmenti-presenting-as-status-epilepticus
#8
Moon Young Seo, Su Jeong You, Soung Hee Kim, Woo Ho Cho, Jong Hee Chae
Incontinentia pigmenti (IP) is an uncommon neurocutaneous syndrome. Its initial diagnosis is based primarily on characteristic papulovesicular skin lesions and early-onset neonatal seizures. In contrast to typical early neurologic manifestations, we encountered a normally developed 6-month-old female patient with hyperpigmented whorls on her body. Following respiratory syncytial virus infection and fever, the patient exhibited status epilepticus. Brain magnetic resonance imaging studies of the patient were compatible with the findings of acute encephalopathy in IP...
December 2017: Journal of Epilepsy Research
https://www.readbyqxmd.com/read/29331320/zika-dengue-and-yellow-fever-viruses-induce-differential-anti-viral-immune-responses-in-human-monocytic-and-first-trimester-trophoblast-cells
#9
Huanle Luo, Evandro R Winkelmann, Ildefonso Fernandez-Salas, Li Li, Sandra V Mayer, Rogelio Daniz-Lozano, Rosa Ma Sanchez-Casas, Nikos Vasilakis, Robert Tesh, Alan D Barrett, Scott C Weaver, Tian Wang
Zika virus (ZIKV) is a mosquito-borne flavivirus associated with severe neonatal birth defects, but the causative mechanism is incompletely understood. ZIKV shares sequence homology and early clinical manifestations with yellow fever virus (YFV) and dengue virus (DENV) and are all transmitted in urban cycles by the same species of mosquitoes. However, YFV and DENV have been rarely reported to cause congenital diseases. Here, we compared infection with a contemporary ZIKV strain (FSS13025) to YFV17D and DENV-4 in human monocytic cells (THP-1) and first-trimester trophoblasts (HTR-8)...
January 10, 2018: Antiviral Research
https://www.readbyqxmd.com/read/29290098/rotavirus-infection-as-a-frequent-cause-of-neonatal-fever
#10
Ha-Na Kang, Hyun Kyung Park, Hyun-Ju Lee, Jin-Hwa Moon, Jae Won Oh, Chang-Ryul Kim
BACKGROUND: Fever rather than diarrhea or vomiting was the most common symptom of neonatal rotavirus(RV) infection in our previous study. We investigated if RV infection is a major cause of neonatal fever and we compared the clinical characteristics of bacterial infections, viral infections and unknown causes of neonatal fever. METHOD: We reviewed the electronic medical records of 48 newborns of ≤ 28 days who were admitted to the Special Care Nursery of Hanyang University Guri Hospital for fever (≥ 38°C) from 2005 to 2009...
December 31, 2017: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/29279439/ventriculitis-unexpectedly-complicating-neonatal-meningitis-caused-by-streptococcus-gallolyticus-subsp-pasteurianus-a-case-report
#11
Yoshiko Yamamura, Yuka Mihara, Keigo Nakatani, Toshihiro Nishiguchi, Tadayoshi Ikebe
Streptococcus gallolyticus subsp. pasteurianus, previously recognized as S. bovis biotype II/2, is an uncommon but important cause of invasive infection in young infants. Here, we report the first case of ventriculitis unexpectedly found in the course of neonatal meningitis due to S. gallolyticus subsp. pasteurianus and review the literature. A 28-day-old Japanese boy presented with fever, lethargy, and irritability. S. bovis was isolated from blood and the cerebrospinal fluid culture and then was identified as S...
December 26, 2017: Japanese Journal of Infectious Diseases
https://www.readbyqxmd.com/read/29219011/meconium-aspiration-syndrome-risk-factors-and-predictors-of-severity
#12
Cláudia Patrícia Lourenço Oliveira, Filipa Flôr-de-Lima, Gustavo Marcondes Duarte Rocha, Ana Paula Machado, Maria Hercília Ferreira Guimarães Pereira Areias
PURPOSE: To identify risk factors and predictors of severity associated with meconium aspiration syndrome (MAS) in the patients admitted to the neonatal intensive care unit (NICU). MATERIALS AND METHODS: Retrospective study including newborns admitted, between 2005 and 2015, with a diagnosis of MAS. RESULTS: Of the newborns admitted to the NICU, 0.66% were diagnosed with MAS. These had higher prevalence of caesarean delivery (p < .001), nonreassuring or abnormal cardiotocography (CTG) (p < ...
December 8, 2017: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29203813/comparison-of-single-and-double-balloon-catheters-for-labor-induction-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#13
Raed Salim, Naama Schwartz, Noah Zafran, Sivan Zuarez-Easton, Gali Garmi, Shabtai Romano
OBJECTIVE: There is a paucity of head-to-head randomized trials that compare single- and double-balloon catheters, and the results of the available data in terms of time from catheter insertion to delivery and delivery mode are mixed. This meta-analysis of randomized controlled trials compares the efficacy of single- and double-balloon catheters in women undergoing labor induction. STUDY DESIGN: Searches were made in MEDLINE, EMBASE, PubMed, ClinicalTrials.gov, and the Cochrane Library from inception through June 2016...
December 4, 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29198381/during-the-emergency-department-evaluation-of-a-well-appearing-neonate-with-fever-should-empiric-acyclovir-be-initiated
#14
Eric Bruno, David Pillus, David Cheng, Gary Vilke, Nicholas Pokrajac
BACKGROUND: Herpes simplex virus (HSV) infection represents significant morbidity and mortality in the neonatal period. Although clear guidelines exist on the evaluation and management of the otherwise well-appearing febrile neonate pertaining to occult serious bacterial infections, there is no standardized approach regarding when to initiate testing and treatment for HSV infection. It is vital we establish a unified guideline based on available clinical research to aid in our decision to evaluate and initiate therapy for this disease...
November 29, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29187210/state-of-newborn-care-in-south-sudan-s-displacement-camps-a-descriptive-study-of-facility-based-deliveries
#15
Samira Sami, Kate Kerber, Solomon Kenyi, Ribka Amsalu, Barbara Tomczyk, Debra Jackson, Alexander Dimiti, Elaine Scudder, Janet Meyers, Jean Paul De Charles Umurungi, Kemish Kenneth, Luke C Mullany
BACKGROUND: Approximately 2.7 million neonatal deaths occur annually, with highest rates of neonatal mortality in countries that have recently experienced conflict. Constant instability in South Sudan further strains a weakened health system and poses public health challenges during the neonatal period. We aimed to describe the state of newborn facility-level care in displaced person camps across Juba, Malakal, and Maban. METHODS: We conducted clinical observations of the labor and delivery period, exit interviews with recently delivered mothers, health facility assessments, and direct observations of midwife time-use...
November 29, 2017: Reproductive Health
https://www.readbyqxmd.com/read/29185016/the-radiological-myometrial-appearance-after-cesarean-section-is-it-associated-with-postpartum-complications-and-subsequent-delivery-outcome
#16
Naama R Bogot, Misagv Rottenstreich, Rinad M Nabulsi, Yonatan Turner, Rivka Farkash, Arnon Samueloff, Sorina Grisaru-Granovsky
PURPOSE: To evaluate whether the characteristics of the radiological uterine myometrial discontinuity (RMD) is associated with maternal-neonatal outcomes and post-cesarean section (CS) complications. A secondary aim was to describe the evolution of the CT uterine surgical incision and the related outcome of a subsequent trial of labor after cesarean (TOLAC). METHODS: Single center retrospective cohort study of CT scans was performed within 6 weeks from cesarean delivery...
November 28, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29180840/candida-chorioamnionitis-leads-to-preterm-birth-and-adverse-fetal-neonatal-outcome
#17
REVIEW
Yohei Maki, Midori Fujisaki, Yuichiro Sato, Hiroshi Sameshima
Candida chorioamnionitis is rare but can lead to neonatal infection, high mortality, and neurodevelopmental impairment. We aimed to investigate maternal clinical features and perinatal outcomes and discuss future management strategies. We reviewed the medical records of women with Candida chorioamnionitis at our hospital over a 10-year period (n = 9) and previous published case reports and case series. The most prevalent Candida species was C. albicans (71.3% of the all cases). The most prevalent predisposing condition was preterm premature rupture of membranes (31/123, 25...
2017: Infectious Diseases in Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29177381/-neonatal-meningitis-in-a-general-hospital-in-lima-peru-2008-to-2015
#18
George Lewis, Maggie Schweig, Daniel Guillén-Pinto, María Luz Rospigliosi
Aiming at describing the incidence, clinical characteristics and factors associated with neonatal meningitis (NM), a case series study was conducted from 2008 to 2015, where 53 neonates, 10 with early onset NM and 43 with late onset were included. An incidence of 1.5 per thousand live births and a lethality of 3.8% were found. The associated factors were peripartum fever, urinary tract infection and chorioamnionitis (P < 0.05). Frequent symptoms were fever (84.9%), hypotonia (77.4%) and hypoactivity (73...
April 2017: Revista Peruana de Medicina Experimental y Salud Pública
https://www.readbyqxmd.com/read/29173788/non-steroidal-anti-inflammatory-drugs-in-newborns-and-infants
#19
REVIEW
Jacob V Aranda, Fabrizio Salomone, Gloria B Valencia, Kay D Beharry
Nonsteroidal antiinflammatory drugs (NSAIDs) and acetaminophen are used in young infants and newborns for pain and fever control, patent ductus closure, prevention of intraventricular hemorrhage, and potentially for prevention of retinopathy of prematurity. These drugs inhibit cyclooxygenase 1 (COX-1), COX-2, and peroxidases, thus, blocking prostaglandin (PG) synthesis. PGs are eicosanoids that regulate several physiologic, pathologic, and cellular processes, including vasomotor tone, platelet aggregation, sensitization of neurons to pain, and many molecular events critical to physiologic homeostasis...
December 2017: Pediatric Clinics of North America
https://www.readbyqxmd.com/read/29142080/human-parechovirus-an-increasingly-recognized-cause-of-sepsis-like-illness-in-young-infants
#20
REVIEW
Laudi Olijve, Lance Jennings, Tony Walls
Human parechovirus (HPeV) is increasingly being recognized as a potentially severe viral infection in neonates and young infants. HPeV belongs to the family Picornaviridae and is currently divided into 19 genotypes. HPeV-1 is the most prevalent genotype and most commonly causes gastrointestinal and respiratory disease. HPeV-3 is clinically the most important genotype due to its association with severe disease in younger infants, which may partly be explained by its distinct virological properties. In young infants, the typical clinical presentation includes fever, severe irritability, and rash, often leading to descriptions of "hot, red, angry babies...
January 2018: Clinical Microbiology Reviews
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