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https://www.readbyqxmd.com/read/28213365/fda-approval-summary-tas-102
#1
Leigh Marcus, Steven J Lemery, Sachia Khasar, Emily Wearne, Whitney S Helms, Weishi Yuan, Kun He, Xianhua Cao, Jingyu Yu, Hong Zhao, Yaning Wang, Olen Stephens, Erika Englund, Rajiv Agarwal, Patricia Keegan, Richard Pazdur
FDA approved TAS-102 (Lonsurf, Taiho Oncology, Inc.) for the treatment of patients with metastatic colorectal cancer (mCRC) who have been previously treated with fluoropyrimidine-, oxaliplatin- and irinotecan-based chemotherapy, an anti-VEGF biological therapy, and if RAS wild-type, an anti-EGFR therapy. In an international, multicenter, double-blinded, placebo-controlled trial (TPU-TAS-102-301, herein referred to as RECOURSE), 800 patients with previously treated mCRC were randomly allocated (2:1) to receive either TAS-102 35mg/m2 orally twice daily after meals on Days 1-5 and 8-12 of each 28-day cycle (n=534) or matching placebo (n=266)...
February 17, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28210748/risk-factors-associated-with-abdominal-obesity-in-suburban-adolescents-from-a-malaysian-district
#2
Wai Fong Chew, Pooi Pooi Leong, Sook Fan Yap, A Malik Yasmin, Kong Bung Choo, Gary Kim Kuan Low, Nem Yun Boo
INTRODUCTION: We aimed to determine the risk factors associated with abdominal obesity (AO) in suburban adolescents. METHODS: This cross-sectional study included adolescents aged 15-17 years from five randomly selected secondary schools in the Hulu Langat district of Selangor State, Malaysia. Waist circumference (WC) was measured at the midpoint between the lower margin of last palpable rib and the top of iliac crest. Information on sociodemographic data, dietary habits, physical activity levels and duration of sleep was obtained via interviewer-administered questionnaires...
February 17, 2017: Singapore Medical Journal
https://www.readbyqxmd.com/read/28198565/training-nonnursing-staff-to-assist-with-nutritional-care-delivery-in-nursing-homes-a-cost-effectiveness-analysis
#3
Sandra F Simmons, Emily K Hollingsworth, Emily A Long, Xulei Liu, Matthew S Shotwell, Emmett Keeler, Ruopeng An, Heidi J Silver
OBJECTIVES: To determine the effect and cost-effectiveness of training nonnursing staff to provide feeding assistance for nutritionally at-risk nursing home (NH) residents. DESIGN: Randomized, controlled trial. SETTING: Five community NHs. PARTICIPANTS: Long-stay NH residents with an order for caloric supplementation (N = 122). INTERVENTION: Research staff provided an 8-hour training curriculum to nonnursing staff...
February 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28196640/risk-of-mental-health-problems-in-adolescents-skipping-meals-the-korean-national-health-and-nutrition-examination-survey-2010-to-2012
#4
Gyungjoo Lee, Kyungdo Han, Hyunju Kim
BACKGROUND: Adolescents frequently skip meals, doing so even more than once per day. This is associated with more mental health problems. PURPOSE: This study identified mental health problems' associations with skipping meals and the frequency thereof among adolescents. METHODS: This cross-sectional population-based study used a data set of 1,413 adolescents from the 2010 to 2012 Korean National Health and Nutrition Examination Survey. Hierarchical multivariable logistic regression was conducted to determine the risk of mental health problems, including stress, depressive mood, and suicidal ideation in relation to skipping meals and the frequency thereof per day...
January 20, 2017: Nursing Outlook
https://www.readbyqxmd.com/read/28187722/effectiveness-of-differing-levels-of-support-for-family-meals-on-obesity-prevention-among-head-start-preschoolers-the-simply-dinner-study
#5
Holly E Brophy-Herb, Mildred Horodynski, Dawn Contreras, Jean Kerver, Niko Kaciroti, Mara Stein, Hannah Jong Lee, Brittany Motz, Sheilah Hebert, Erika Prine, Candace Gardiner, Laurie A Van Egeren, Julie C Lumeng
BACKGROUND: Despite slight decreases in obesity prevalence in children, nearly 25% of preschool-aged children are overweight or obese. Most interventions focused on promoting family meals as an obesity-prevention strategy target meal planning skills, knowledge and modeling of healthy eating without addressing the practical resources that enable implementation of family meals. There is a striking lack of evidence about what level of resources low-income parents need to implement family meals...
February 10, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28185876/associations-between-food-consumption-patterns-and-saliva-composition-specificities-of-eating-difficulties-children
#6
Martine Morzel, Caroline Truntzer, Eric Neyraud, Hélène Brignot, Patrick Ducoroy, Géraldine Lucchi, Cécile Canlet, Ségolène Gaillard, Florian Nicod, Sophie Nicklaus, Noël Peretti, Gilles Feron
Identifying objective markers of diet would be beneficial to research fields such as nutritional epidemiology. As a preliminary study on the validity of using saliva for this purpose, and in order to explore the relationship between saliva and diet, we focused on clearly contrasted groups of children: children with eating difficulties (ED) receiving at least 50% of their energy intake through artificial nutrition vs healthy controls (C). Saliva of ED and C children was analyzed by various methods (targeted biochemical analyses, 2-D electrophoresis coupled to MS, (1)H NMR) and their diet was characterized using food frequency questionnaires, considering 148 food items grouped into 13 categories...
February 6, 2017: Physiology & Behavior
https://www.readbyqxmd.com/read/28183311/evaluation-of-the-antidiarrheal-activity-of-the-leaf-extracts-of-myrtus-communis-linn-myrtaceae-in-mice-model
#7
Mekonnen Sisay, Ephrem Engidawork, Workineh Shibeshi
BACKGROUND: Myrtus communis L. has a folkloric repute for the management of diarrhea and dysentery in different parts of the world. However, the safety and efficacy of the leaf extract have not been scientifically validated in animal model. This study was, therefore, aimed to investigate the antidiarrheal effect of 80% methanol extract (80ME) and solvent fractions of the leaves of Myrtus communis L. in mice. METHODS: The antidiarrheal activity of the 80ME and solvent fractions was evaluated against castor oil induced diarrheal model, charcoal meal and enteropooling tests...
February 10, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28163776/tolerable-pain-reduces-gastric-fundal-accommodation-and-gastric-motility-in-healthy-subjects-a-crossover-ultrasonographic-study
#8
Hideaki Hasuo, Hiroaki Kusunoki, Kenji Kanbara, Tetsuya Abe, Naoko Yunoki, Ken Haruma, Mikihiko Fukunaga
BACKGROUND: Obstacles to pain management include patients' reluctance to inform healthcare provides about their pain, and differences in the pain management aims between patients and healthcare providers. The objective of this study was to evaluate whether tolerable pain influences gastric fundal accommodation and gastric motility in healthy subjects. METHODS: We undertook a crossover comparison study to evaluate gastric fundal accommodation and gastric motility in 74 healthy subjects in the presence or absence of tolerable pain...
2017: BioPsychoSocial Medicine
https://www.readbyqxmd.com/read/28163563/testing-a-brief-substance-misuse-preventive-intervention-for-parents-of-pre-adolescents-feasibility-acceptability-preliminary-efficacy
#9
Margie R Skeer, Konstantina E Yantsides, Misha Eliasziw, Allison Carlton-Smith, Migdalia Tracy, Anthony Spirito
Evidence-based interventions to reduce substance misuse among adolescents are resource and time intensive. We conducted a pilot RCT to evaluate a novel, adaptable, and resource-efficient substance misuse preventive intervention for parents/guardians, focusing on talking with children about substance use and on eating family meals. We randomized 70 parents of children in third-through-sixth grades within a large, urban public school system in New England to the intervention or control condition. Over a six-month follow-up period, we assessed feasibility and acceptability of the intervention and examined frequency of parent-child conversations about alcohol, marijuana, and other drugs, and frequency and duration of family meals...
December 2016: Journal of Child and Family Studies
https://www.readbyqxmd.com/read/28153814/weight-loss-associated-with-different-patterns-of-self-monitoring-using-the-mobile-phone-app-my-meal-mate
#10
Michelle C Carter, Victoria J Burley, Janet E Cade
BACKGROUND: Obesity is a major global public health issue due to its association with a number of serious chronic illnesses and its high economic burden to health care providers. Self-monitoring of diet has been consistently linked to weight loss. However, there is limited evidence about how frequently individuals need to monitor their diet for optimal weight loss. OBJECTIVE: The aim of this paper is to describe app usage frequency and pattern in the mobile phone arm of a previously conducted randomized controlled trial...
February 2, 2017: JMIR MHealth and UHealth
https://www.readbyqxmd.com/read/28153017/meal-planning-is-associated-with-food-variety-diet-quality-and-body-weight-status-in-a-large-sample-of-french-adults
#11
Pauline Ducrot, Caroline Méjean, Vani Aroumougame, Gladys Ibanez, Benjamin Allès, Emmanuelle Kesse-Guyot, Serge Hercberg, Sandrine Péneau
BACKGROUND: Meal planning could be a potential tool to offset time scarcity and therefore encourage home meal preparation, which has been linked with an improved diet quality. However, to date, meal planning has received little attention in the scientific literature. The aim of our cross-sectional study was to investigate the association between meal planning and diet quality, including adherence to nutritional guidelines and food variety, as well as weight status. METHODS: Meal planning, i...
February 2, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28142202/new-film-coated-tablet-formulation-of-deferasirox-is-well-tolerated-in-patients-with-thalassemia-or-lower-risk-mds-results-of-the-randomized-phase-ii-eclipse-study
#12
Ali T Taher, Raffaella Origa, Silverio Perrotta, Alexandra Kourakli, Giovan Battista Ruffo, Antonis Kattamis, Ai-Sim Goh, Annelore Cortoos, Vicky Huang, Marine Weill, Raquel Merino Herranz, John B Porter
Once-daily deferasirox dispersible tablets (DT) have a well-defined safety and efficacy profile and, compared with parenteral deferoxamine, provide greater patient adherence, satisfaction, and quality of life. However, barriers still exist to optimal adherence, including gastrointestinal tolerability and palatability, leading to development of a new film-coated tablet (FCT) formulation that can be swallowed with a light meal, without the need to disperse into a suspension prior to consumption. The randomized, open-label, Phase II ECLIPSE study evaluated the safety of deferasirox DT and FCT formulations over 24 weeks in chelation-naïve or pre-treated patients aged ≥10 years, with transfusion-dependent thalassemia or IPSS-R very-low-, low- or intermediate-risk myelodysplastic syndromes...
January 31, 2017: American Journal of Hematology
https://www.readbyqxmd.com/read/28137935/meal-timing-and-frequency-implications-for-cardiovascular-disease-prevention-a-scientific-statement-from-the-american-heart-association
#13
Marie-Pierre St-Onge, Jamy Ard, Monica L Baskin, Stephanie E Chiuve, Heather M Johnson, Penny Kris-Etherton, Krista Varady
Eating patterns are increasingly varied. Typical breakfast, lunch, and dinner meals are difficult to distinguish because skipping meals and snacking have become more prevalent. Such eating styles can have various effects on cardiometabolic health markers, namely obesity, lipid profile, insulin resistance, and blood pressure. In this statement, we review the cardiometabolic health effects of specific eating patterns: skipping breakfast, intermittent fasting, meal frequency (number of daily eating occasions), and timing of eating occasions...
January 30, 2017: Circulation
https://www.readbyqxmd.com/read/28130870/analysis-of-inedible-substance-ingestion-at-a-japanese-psychiatric-hospital
#14
So Yayama, Chie Tanimoto, Shunji Suto, Kei Matoba, Tomomi Kajiwara, Masue Inoue, Yoshimi Endo, Miyae Yamakawa, Kiyoko Makimoto
BACKGROUND: Inedible substance ingestion increases the risk of ileus, poisoning, and suffocation. Prevention is especially important in a psychiatric setting. This study aimed to analyze the incidence of inedible substance ingestion in a Japanese psychiatric hospital. METHODS: Inedible substance ingestion incidents were extracted from an incident report database spanning 2000-2012 at a 400-bed psychiatric hospital in Japan. We tabulated the frequencies of incidents in accordance with major diagnosis, ingested materials, incident levels, and time of occurrence...
January 27, 2017: Psychogeriatrics: the Official Journal of the Japanese Psychogeriatric Society
https://www.readbyqxmd.com/read/28118839/family-meals-with-young-children-an-online-study-of-family-mealtime-characteristics-among-australian-families-with-children-aged-six-months-to-six-years
#15
Eloise-Kate V Litterbach, Karen J Campbell, Alison C Spence
BACKGROUND: Evidence suggests that family meals influence food intakes and behaviours, which in turn impact children's eating habits, diets and health. Mealtimes therefore offer potential as settings for health promotion. Given diet, health behaviours and health are often socioeconomically patterned, it is important to consider whether family meals differ by socioeconomic position (SEP). METHODS: The Family Meals with Young Kids study was an online survey completed by parents in 2014...
January 24, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28117542/the-additional-dose-of-insulin-for-high-protein-mixed-meal-provides-better-glycemic-control-in-children-with-type-1-diabetes-on-insulin-pumps-randomized-cross-over-study
#16
Katarzyna Piechowiak, Katarzyna Dżygało, Agnieszka Szypowska
BACKGROUND: Delivery of insulin for high-protein low-fat meals with carbohydrates on the basis of carbohydrates leads to higher late postprandial glycemia. Studies with mixed meals demonstrated lower blood glucose level after dual wave bolus. The objective of our study was to assess the impact of additional dose of insulin in dual wave bolus for high-protein mixed meal on the postprandial glycemia. MATERIALS AND METHODS: We performed a randomized, double-blind, two-way cross-over study, including 58 children with type 1 diabetes, aged 14...
January 24, 2017: Pediatric Diabetes
https://www.readbyqxmd.com/read/28116075/effects-of-liquid-feeding-of-corn-condensed-distiller-s-solubles-and-whole-stillage-on-growth-performance-carcass-characteristics-and-sensory-traits-of-pigs
#17
Xiaojian Yang, Carissa Nath, Alan Doering, John Goihl, Samuel Kofi Baidoo
BACKGROUND: The immense growth in global bioethanol production has greatly increased the supply of by-products such as whole stillage and condensed distiller's solubles, which could be potentially used for animal feeding. The objective of this study was to investigate effects of liquid feeding high levels of corn condensed distiller's solubles (CCDS) and whole stillage (CWS) on growth performance, carcass characteristics, belly firmness and meat sensory traits of pigs. METHODS: A total of 256 pigs were blocked by sex and initial BW (13...
2017: Journal of Animal Science and Biotechnology
https://www.readbyqxmd.com/read/28109763/healthier-children-s-meals-in-restaurants-an%C3%A2-exploratory-study-to-inform-approaches-that%C3%A2-are-acceptable-across-stakeholders
#18
Stephanie Anzman-Frasca, Sara C Folta, Meaghan E Glenn, Anita Jones-Mueller, Vanessa M Lynskey, Anjali A Patel, Lisa L Tse, Nanette V Lopez
OBJECTIVE: Assess parents', children's, and restaurant executives' perspectives on children's meals in restaurants. DESIGN: Cross-sectional. SETTING: Parents and children completed predominantly quantitative surveys at 4 quick- and full-service restaurant locations. Telephone interviews were conducted with executives representing additional restaurants. PARTICIPANTS: Parents (n = 59) and their first- through fourth-grade children (n = 58); executives (n = 4)...
January 18, 2017: Journal of Nutrition Education and Behavior
https://www.readbyqxmd.com/read/28109417/associations-of-cooking-with-dietary-intake-and-obesity-among-supplemental-nutrition-assistance-program-participants
#19
Lindsey Smith Taillie, Jennifer M Poti
INTRODUCTION: Participation in the Supplemental Nutrition Assistance Program (SNAP) may help ease economic and time constraints of cooking, helping low-income households prepare healthier meals. Therefore, frequent cooking may be more strongly associated with improved dietary outcomes among SNAP recipients than among income-eligible non-recipients. Alternately, increased frequency of home-cooked meals among SNAP participants may be beneficial simply by replacing fast food intake. This study quantified the association between home cooking and fast food with diet intake and weight status among SNAP recipients...
February 2017: American Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28106815/social-dysfunction-and-diet-outcomes-in-people-with-psychosis
#20
Doreen Mucheru, Mary-Claire Hanlon, Linda E Campbell, Mark McEvoy, Lesley MacDonald-Wicks
This analysis aimed to examine the association of social dysfunction with food security status, fruit intake, vegetable intake, meal frequency and breakfast consumption in people with psychosis from the Hunter New England (HNE) catchment site of the Survey of High Impact Psychosis (SHIP). Social dysfunction and dietary information were collected using standardised tools. Independent binary logistic regressions were used to examine the association between social dysfunction and food security status, fruit intake, vegetable intake, meal frequency and breakfast consumption...
January 19, 2017: Nutrients
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