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https://www.readbyqxmd.com/read/28749854/risk-stratification-in-pediatric-acute-respiratory-distress-syndrome-a-multicenter-observational-study
#1
Judith Ju-Ming Wong, Huu Phuc Phan, Suwannee Phumeetham, Jacqueline Soo May Ong, Yek Kee Chor, Suyun Qian, Rujipat Samransamruajkit, Nattachai Anantasit, Chin Seng Gan, Feng Xu, Rehena Sultana, Tsee Foong Loh, Jan Hau Lee
OBJECTIVES: The Pediatric Acute Lung Injury Consensus Conference developed a pediatric specific definition for acute respiratory distress syndrome (PARDS). In this definition, severity of lung disease is stratified into mild, moderate, and severe groups. We aim to describe the epidemiology of patients with PARDS across Asia and evaluate whether the Pediatric Acute Lung Injury Consensus Conference risk stratification accurately predicts outcome in PARDS. DESIGN: A multicenter, retrospective, descriptive cohort study...
July 26, 2017: Critical Care Medicine
https://www.readbyqxmd.com/read/28738950/a-decade-evaluation-of-a-state-trauma-system-has-access-to-inpatient-trauma-care-at-designated-trauma-centers-improved
#2
Dennis W Ashley, Etienne E Pracht, Regina S Medeiros, Elizabeth V Atkins, Elizabeth G Nesmith, Tracy J Johns, James R Dunne, Jeffrey M Nicholas
Recently, the trauma center component of the Georgia trauma system was evaluated demonstrating a 10 per cent probability of increased survival for severely injured patients treated at designated trauma centers (DTCs) versus nontrauma centers. The purpose of this study was to determine the effectiveness of a state trauma system to provide access to inpatient trauma care at DTCs for its residents. We reviewed 371,786 patients from the state's discharge database and identified 255,657 treated at either a DTC or a nontrauma center between 2003 and 2012...
July 1, 2017: American Surgeon
https://www.readbyqxmd.com/read/28732652/correlation-of-tenascin-c-concentrations-in-serum-with-outcome-of-traumatic-brain-injury-in-humans
#3
Yuan-Yuan Zhao, Lin Lou, Kai-Chuang Yang, Hai-Bo Wang, Yan Xu, Gang Lu, Hai-Yan He
BACKGROUND: Tenascin-C, a matricellular protein, is involved in brain injury. However, change of tenascin-C concentrations in peripheral blood remains unknown after traumatic brain injury (TBI). METHODS: Serum tenascin-C concentrations were measured in 100 healthy controls, 108 severe TBI patients, 79 moderate TBI patients and 32 mild TBI patients. RESULTS: Serum tenascin-C concentrations of patients were significantly higher than those of controls...
July 18, 2017: Clinica Chimica Acta; International Journal of Clinical Chemistry
https://www.readbyqxmd.com/read/28731870/the-association-of-cognitive-reserve-in-chronic-phase-functional-and-neuropsychological-outcomes-following-traumatic-brain-injury
#4
Jacob B Leary, Grace Y Kim, Catherine L Bradley, Uzma Z Hussain, Maryanne Sacco, Martha Bernad, John Collins, John Dsurney, Leighton Chan
OBJECTIVE: Examine the association of cognitive reserve (CR) factors (estimated premorbid intelligence quotient [IQ], years of education, and occupational attainment) and traumatic brain injury (TBI) severity with functional and neuropsychological outcomes 1 to 5 years following TBI. PARTICIPANTS: Patients with mild (N = 58), moderate (N = 25), or severe (N = 17) TBI. MAIN MEASURES: Cognitive reserve factors (estimated premorbid IQ, years of education, and occupational attainment); neuropsychological test battery; Glasgow Outcome Scale-Extended; Short Form-36 Health Survey...
July 20, 2017: Journal of Head Trauma Rehabilitation
https://www.readbyqxmd.com/read/28728464/repeat-mild-traumatic-brain-injury-in-adolescent-rats-increases-subsequent-%C3%AE-amyloid-pathogenesis
#5
Daya Alexander Grant, Rebecka Serpa, Cameron R Moattari, Ari Brown, Tiffany Greco, Mayumi Prins, Edmond Teng
Single moderate-to-severe traumatic brain injuries (TBIs) may increase subsequent risk for neurodegenerative disease by facilitating β-amyloid (Aβ) deposition. However, the chronic effects on Aβ pathogenesis of repetitive mild TBIs, which are common in adolescents and young adults, remain uncertain. We examined the effects of repetitive mild TBI sustained during adolescence on subsequent deposition of Aβ pathology in a transgenic APP/PS1 rat model. Transgenic rats received sham or four individual mild TBI (rTBI) separated by either 24- or 72-hour intervals at post-natal day 35 (prior to Aβ plaque deposition)...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28727580/increase-in-intracranial-pressure-by-application-of-a-rigid-cervical-collar-a-pilot-study-in-healthy-volunteers
#6
Iscander M Maissan, Rein Ketelaars, Boris Vlottes, Sanne E Hoeks, Dennis den Hartog, Robert J Stolker
OBJECTIVES: Rigid cervical collars are known to increase intracranial pressure (ICP) in severe traumatic brain injury (TBI). Cerebral blood flow might decrease according to the Kellie Monroe doctrine. For this reason, the use of the collar in patients with severe TBI has been abandoned from several trauma protocols in the Netherlands. There is no evidence on the effect of a rigid collar on ICP in patients with mild or moderate TBI or indeed patients with no TBI. As a first step we tested the effect in healthy volunteers with normal ICPs and intact autoregulation of the brain...
July 19, 2017: European Journal of Emergency Medicine: Official Journal of the European Society for Emergency Medicine
https://www.readbyqxmd.com/read/28726590/a-method-of-managing-severe-traumatic-brain-injury-in-the-absence-of-intracranial-pressure-monitoring-the-ice-protocol
#7
Randall Chesnut, Nancy Temkin, Sureyya Dikmen, Carlos Rondina, Walter Videtta, Gustavo Petroni, Silvia Lujan, Victor Alanis, Antonio Luis Eiras Falcao, Gustavo La Fuente, Luis Gonzalez, Manuel Jibaja, Arturo Lavendez, Freddy Sandi Lora, Roberto Merida, Ricardo Romero, James Pridgeon, Jason Barber, Joan Machamer, Kelley Chaddock
Purpose - The imaging- and clinical-examination (ICE) algorithm used in the BEST TRIP ICP randomized controlled trial is the only prospectively investigated clinical protocol for TBI management without ICP monitoring. As the default literature standard, it warrants careful evaluation. Methods - We present the ICE protocol in detail and analyse the demographics, outcome, treatment intensity, frequency of intervention usage, and related adverse events in the ICE-protocol cohort. Results - The 167 ICE protocol patients were young (median 29 years) with a median Glasgow Coma Scale motor score of 4 but with anisocoria or abnormal pupillary reactivity in 40%...
July 20, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28725550/dti-measures-identify-mild-and-moderate-tbi-cases-among-patients-with-complex-health-problems-a-receiver-operating-characteristic-analysis-of-u-s-veterans
#8
Keith L Main, Salil Soman, Franco Pestilli, Ansgar Furst, Art Noda, Beatriz Hernandez, Jennifer Kong, Jauhtai Cheng, Jennifer K Fairchild, Joy Taylor, Jerome Yesavage, J Wesson Ashford, Helena Kraemer, Maheen M Adamson
Standard MRI methods are often inadequate for identifying mild traumatic brain injury (TBI). Advances in diffusion tensor imaging now provide potential biomarkers of TBI among white matter fascicles (tracts). However, it is still unclear which tracts are most pertinent to TBI diagnosis. This study ranked fiber tracts on their ability to discriminate patients with and without TBI. We acquired diffusion tensor imaging data from military veterans admitted to a polytrauma clinic (Overall n = 109; Age: M = 47...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28724466/home-environment-as-a-predictor-of-long-term-executive-functioning-following-early-childhood-traumatic-brain-injury
#9
Christianne Laliberté Durish, Keith Owen Yeates, Terry Stancin, H Gerry Taylor, Nicolay C Walz, Shari L Wade
OBJECTIVES: This study examined the relationship of the home environment to long-term executive functioning (EF) following early childhood traumatic brain injury (TBI). METHODS: Participants (N=134) were drawn from a larger parent study of 3- to 6-year-old children hospitalized for severe TBI (n=16), complicated mild/moderate TBI (n=44), or orthopedic injury (OI; n=74), recruited prospectively at four tertiary care hospitals in the United States and followed for an average of 6...
July 20, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28724317/who-among-patients-with-acquired-brain-injury-returned-to-work-after-occupational-rehabilitation-the-rapid-return-to-work-cohort-study
#10
Randi Wågø Aas, Lise Aasen Haveraaen, Evelien P M Brouwers, Lisebet Skeie Skarpaas
BACKGROUND: Acquired brain injury (ABI) is known to be severely disabling. On average, 40% of employees return to work (RTW) within two years after injury. There is, however, limited research on what might contribute to successful RTW. AIM: To examine factors that might impact the time-to first RTW for patients with ABI, participating in a RTW-program. METHODS: The study was designed as a cohort study of patients on sick leave due to mild or moderate ABI (n = 137)...
July 20, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28719989/table-saw-injuries-are-our-safety-features-really-keeping-us-safe
#11
Sarah E Smith, Ian Kendrick, Thomas Huntsman
BACKGROUND: Currently, table saws sold in the United States have 3 safety features (riving knife, blade guard, and antikickback device) designed to prevent personal injury; however, these features can hinder the user's movements and are often disabled or removed. Despite the frequency of table saw injuries, there is relatively limited literature regarding them. METHODS: We performed a retrospective, observational study of characteristics associated with injuries incurred while using a table saw...
March 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28718250/qing-qi-rickshaw-a-boon-or-bane-for-public-transportation-a-study-of-road-traffic-injury-patterns-involving-qing-qi-rickshaws-in-karachi-pakistan
#12
Muhammad Muzzammil, Muhammad Saeed Minhas, Jahanzeb Effendi, Syed Jahanzeb, Ayesha Mughal, Abdul Qadir
BACKGROUND: The three-wheeler Qing-qi and Compressed Natural Gas (CNG) auto-rickshaws were introduced in Karachi to meet the transportation demand of the growing population. These vehicles have directly or indirectly been implicated in a number of road traffic violations as well as road accidents. This study aims to describe the crash characteristics and injury patterns for Qing-qi rickshaw occupants and other road users hit by Qing-qi rickshaw in Karachi, Pakistan. METHODS: An Observational/ Descriptive study was conducted at Accident & Emergency and Orthopaedic Surgery Department, Jinnah Post Graduate Medical Centre, Karachi Pakistan from July 2014 to June 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28714885/differences-in-genetic-background-contribute-to-pseudomonas-exotoxin-a-induced-hepatotoxicity-in-rats
#13
Chien-Chao Chiu, Yu-Chih Wang, Wen-Ching Huang, Yi-Hsun Chen, Shao-Wen Hung, Yen-Te Huang, Hsiao-Li Chuang, Yi-Chih Chang
Pseudomonas aeruginosa exotoxin A (PEA) causes severe hepatotoxicity in experimental animals and is useful in investigations of immune-mediated liver injury. However, strain differences in the sensitivity to PEA-induced hepatotoxicity in rats remains be elucidated. In this study, we determined the severity of PEA-induced hepatotoxicity in six genetically different rat strains. Male LE (Long Evans), Wistar, F344, WKY, BN/SsN and LEW rats were administered a single intravenous injection of PEA (20 μg/kg). Significantly elevated serum ALT and AST levels, massive necrosis and hemorrhage, and numerous TUNEL-positive hepatocytes were observed in BN/SsN rats...
July 15, 2017: Toxins
https://www.readbyqxmd.com/read/28709880/low-intensity-transcranial-electric-stimulation-safety-ethical-legal-regulatory-and-application-guidelines
#14
REVIEW
A Antal, I Alekseichuk, M Bikson, J Brockmöller, A R Brunoni, R Chen, L G Cohen, G Dowthwaite, J Ellrich, A Flöel, F Fregni, M S George, R Hamilton, J Haueisen, C S Herrmann, F C Hummel, J P Lefaucheur, D Liebetanz, C K Loo, C D McCaig, C Miniussi, P C Miranda, V Moliadze, M A Nitsche, R Nowak, F Padberg, A Pascual-Leone, W Poppendieck, A Priori, S Rossi, P M Rossini, J Rothwell, M A Rueger, G Ruffini, K Schellhorn, H R Siebner, Y Ugawa, A Wexler, U Ziemann, M Hallett, W Paulus
Low intensity transcranial electrical stimulation (TES) in humans, encompassing transcranial direct current (tDCS), transcutaneous spinal Direct Current Stimulation (tsDCS), transcranial alternating current (tACS), and transcranial random noise (tRNS) stimulation or their combinations, appears to be safe. No serious adverse events (SAEs) have been reported so far in over 18,000 sessions administered to healthy subjects, neurological and psychiatric patients, as summarized here. Moderate adverse events (AEs), as defined by the necessity to intervene, are rare, and include skin burns with tDCS due to suboptimal electrode-skin contact...
June 19, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/28705261/-cutting-non-suicidal-self-injury-nssi-on-instagram
#15
R C Brown, T Fischer, A D Goldwich, F Keller, R Young, P L Plener
BACKGROUND: Social media presents an important means for social interaction, especially among adolescents, with Instagram being the most popular platform in this age-group. Pictures and communication about non-suicidal self-injury (NSSI) can frequently be found on the internet. METHODS: During 4 weeks in April 2016, n = 2826 (from n = 1154 accounts) pictures which directly depicted wounds on Instagram were investigated. Those pictures, associated comments, and user accounts were independently rated for content...
July 14, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28702121/occurrence-of-femoral-nerve-injury-among-patients-undergoing-transfemoral-percutaneous-catheterization-procedures-in-the-united-states
#16
Mohammad El-Ghanem, Ahmed A Malik, Andre Azzam, Hussam A Yacoub, Adnan I Qureshi, Nizar Souayah
BACKGROUND: The proximity of the femoral nerve to the femoral artery renders it vulnerable to injury during transfemoral percutaneous catheterization (TPC) procedures. OBJECTIVE: To determine the incidence of femoral nerve injury in patients undergoing cardiac catheterization in a nationally representative inpatient database. METHODS: We analyzed data released annually from the Nationwide Inpatient Sample. We pooled data from 2002 to 2010 and, using the ICD-9-CM procedure codes, identified patients who underwent TPC...
June 2017: Journal of Vascular and Interventional Neurology
https://www.readbyqxmd.com/read/28692408/preliminary-findings-of-altered-functional-connectivity-of-the-default-mode-network-linked-to-functional-outcomes-one-year-after-pediatric-traumatic-brain-injury
#17
Jaclyn A Stephens, Cynthia F Salorio, Anita D Barber, Sarah R Risen, Stewart H Mostofsky, Stacy J Suskauer
PURPOSE AND METHOD: This study examined functional connectivity of the default mode network (DMN) and examined brain-behavior relationships in a pilot cohort of children with chronic mild to moderate traumatic brain injury (TBI). RESULTS: Compared to uninjured peers, children with TBI demonstrated less anti-correlated functional connectivity between DMN and right Brodmann Area 40 (BA 40). In children with TBI, more anomalous less anti-correlated) connectivity between DMN and right BA 40 was linked to poorer performance on response inhibition tasks...
July 10, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28692352/responsiveness-and-discriminant-validity-of-the-child-and-adolescent-scale-of-participation-across-three-years-for-children-and-youth-with-traumatic-brain-injury
#18
Anat Golos, Gary Bedell
PURPOSE: To examine responsiveness and discriminant validity of the Child and Adolescent Scale of Participation (CASP) across three years. METHODS: Examined longitudinal data on 515 children and youth with TBI and arm injuries. Repeated measures analyses of variance were used to examine CASP scores (pre-injury; 3, 12, 24, 36 months post-injury). RESULTS: Scores decreased from pre-injury to 3 months, but significantly only for moderate and severe TBI groups...
July 10, 2017: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/28689194/risk-factors-and-outcomes-associated-with-post-traumatic-headache-after-mild-traumatic-brain-injury
#19
Yilmaz Tansel, Gerwin Roks, Myrthe de Koning, Myrthe Scheenen, Harm van der Horn, Gerben Plas, Gerard Hageman, Guus Schoonman, Jacoba Spikman, Joukje van der Naalt
OBJECTIVES: To determine the prevalence and potential risk factors of acute and chronic post-traumatic headache (PTH) in patients with mild to moderate traumatic brain injury (TBI) in a prospective longitudinal observational multicentre study. Acute PTH (aPTH) is defined by new or worsening of pre-existing headache occurring within 7 days after trauma, whereas chronic PTH (cPTH) is defined as persisting aPTH >3 months after trauma. An additional goal was to study the impact of aPTH and cPTH in terms of return to work (RTW), anxiety and depression...
July 8, 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28678790/risk-of-hospitalization-with-neurodegenerative-disease-after-moderate-to-severe-traumatic-brain-injury-in-the-working-age-population-a-retrospective-cohort-study-using-the-finnish-national-health-registries
#20
Rahul Raj, Jaakko Kaprio, Miikka Korja, Era D Mikkonen, Pekka Jousilahti, Jari Siironen
BACKGROUND: Previous epidemiological studies suggest that working-aged persons with a history of moderate-to-severe traumatic brain injury (TBI) may have an increased risk for developing neurodegenerative disease (NDD) while persons with a history of mild TBI do not. In this comprehensive nationwide study in Finland, we assessed the risk of NDD and history of moderate-to-severe TBI in the working-age population. METHODS AND FINDINGS: We performed a population-based follow-up study using the Finnish Care Register for Health Care to identify all persons between the ages of 18 and 65 years hospitalized during 1987-2014 due to TBI who did not have a baseline NDD diagnosis...
July 2017: PLoS Medicine
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