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https://www.readbyqxmd.com/read/27919863/applying-multiple-data-collection-tools-to-quantify-human-papillomavirus-vaccine-communication-on-twitter
#1
Philip M Massey, Amy Leader, Elad Yom-Tov, Alexandra Budenz, Kara Fisher, Ann C Klassen
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection in the United States. There are several vaccines that protect against strains of HPV most associated with cervical and other cancers. Thus, HPV vaccination has become an important component of adolescent preventive health care. As media evolves, more information about HPV vaccination is shifting to social media platforms such as Twitter. Health information consumed on social media may be especially influential for segments of society such as younger populations, as well as ethnic and racial minorities...
December 5, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27905515/neonicotinoid-induced-impairment-of-odour-coding-in-the-honeybee
#2
Mara Andrione, Giorgio Vallortigara, Renzo Antolini, Albrecht Haase
Exposure to neonicotinoid pesticides is considered one of the possible causes of honeybee (Apis mellifera) population decline. At sublethal doses, these chemicals have been shown to negatively affect a number of behaviours, including performance of olfactory learning and memory, due to their interference with acetylcholine signalling in the mushroom bodies. Here we provide evidence that neonicotinoids can affect odour coding upstream of the mushroom bodies, in the first odour processing centres of the honeybee brain, i...
December 1, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27895050/social-signals-and-aversive-learning-in-honey-bee-drones-and-workers
#3
Arian Avalos, Eddie Pérez, Lianna Vallejo, María E Pérez, Charles I Abramson, Tugrul Giray
The dissemination of information is a basic element of group cohesion. In honey bees (Apis mellifera Linnaeus 1758), like in other social insects, the principal method for colony-wide information exchange is communication via pheromones. This medium of communication allows multiple individuals to conduct tasks critical to colony survival. Social signaling also establishes conflict at the level of the individual who must tradeoff between attending to the immediate environment or the social demand. In this study we examined this conflict by challenging highly social worker honey bees, and less social male drone honey bees undergoing aversive training by presenting them with a social stress signal (isopentyl acetate, IPA)...
November 28, 2016: Biology Open
https://www.readbyqxmd.com/read/27819118/current-knowledge-of-detoxification-mechanisms-of-xenobiotic-in-honey-bees
#4
REVIEW
Youhui Gong, Qingyun Diao
The western honey bee Apis mellifera is the most important managed pollinator species in the world. Multiple factors have been implicated as potential causes or factors contributing to colony collapse disorder, including honey bee pathogens and nutritional deficiencies as well as exposure to pesticides. Honey bees' genome is characterized by a paucity of genes associated with detoxification, which makes them vulnerable to specific pesticides, especially to combinations of pesticides in real field environments...
November 7, 2016: Ecotoxicology
https://www.readbyqxmd.com/read/27730415/machine-learning-interface-for-medical-image-analysis
#5
Yi C Zhang, Alexander C Kagen
TensorFlow is a second-generation open-source machine learning software library with a built-in framework for implementing neural networks in wide variety of perceptual tasks. Although TensorFlow usage is well established with computer vision datasets, the TensorFlow interface with DICOM formats for medical imaging remains to be established. Our goal is to extend the TensorFlow API to accept raw DICOM images as input; 1513 DaTscan DICOM images were obtained from the Parkinson's Progression Markers Initiative (PPMI) database...
October 11, 2016: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/27699501/the-glass-is-not-yet-half-empty-agitation-but-not-varroa-treatment-causes-cognitive-bias-in-honey-bees
#6
Helge Schlüns, Helena Welling, Julian René Federici, Lars Lewejohann
Honey bees (Apis mellifera) are prone to judge an ambiguous stimulus negatively if they had been agitated through shaking which simulates a predator attack. Such a cognitive bias has been suggested to reflect an internal emotional state analogous to humans who judge more pessimistically when they do not feel well. In order to test cognitive bias experimentally, an animal is conditioned to respond to two different stimuli, where one is punished while the other is rewarded. Subsequently a third, ambiguous stimulus is presented and it is measured whether the subject responds as if it expects a reward or a punishment...
October 3, 2016: Animal Cognition
https://www.readbyqxmd.com/read/27694209/asap-a-machine-learning-framework-for-local-protein-properties
#7
Nadav Brandes, Dan Ofer, Michal Linial
Determining residue-level protein properties, such as sites of post-translational modifications (PTMs), is vital to understanding protein function. Experimental methods are costly and time-consuming, while traditional rule-based computational methods fail to annotate sites lacking substantial similarity. Machine Learning (ML) methods are becoming fundamental in annotating unknown proteins and their heterogeneous properties. We present ASAP (Amino-acid Sequence Annotation Prediction), a universal ML framework for predicting residue-level properties...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27693138/honeybees-learn-landscape-features-during-exploratory-orientation-flights
#8
Jacqueline Degen, Andreas Kirbach, Lutz Reiter, Konstantin Lehmann, Philipp Norton, Mona Storms, Miriam Koblofsky, Sarah Winter, Petya B Georgieva, Hai Nguyen, Hayfe Chamkhi, Hanno Meyer, Pawan K Singh, Gisela Manz, Uwe Greggers, Randolf Menzel
Exploration is an elementary and fundamental form of learning about the structure of the world [1-3]. Little is known about what exactly is learned when an animal seeks to become familiar with the environment. Navigating animals explore the environment for safe return to an important place (e.g., a nest site) and to travel between places [4]. Flying central-place foragers like honeybees (Apis mellifera) extend their exploration into distances from which the features of the nest cannot be directly perceived [5-10]...
September 24, 2016: Current Biology: CB
https://www.readbyqxmd.com/read/27672359/dna-methylation-adjusts-the-specificity-of-memories-depending-on-the-learning-context-and-promotes-relearning-in-honeybees
#9
Stephanie D Biergans, Charles Claudianos, Judith Reinhard, C G Galizia
The activity of the epigenetic writers DNA methyltransferases (Dnmts) after olfactory reward conditioning is important for both stimulus-specific long-term memory (LTM) formation and extinction. It, however, remains unknown which components of memory formation Dnmts regulate (e.g., associative vs. non-associative) and in what context (e.g., varying training conditions). Here, we address these aspects in order to clarify the role of Dnmt-mediated DNA methylation in memory formation. We used a pharmacological Dnmt inhibitor and classical appetitive conditioning in the honeybee Apis mellifera, a well characterized model for classical conditioning...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27626797/operant-conditioning-in-honey-bees-apis-mellifera-l-the-cap-pushing-response
#10
Charles I Abramson, Christopher W Dinges, Harrington Wells
The honey bee has been an important model organism for studying learning and memory. More recently, the honey bee has become a valuable model to understand perception and cognition. However, the techniques used to explore psychological phenomena in honey bees have been limited to only a few primary methodologies such as the proboscis extension reflex, sting extension reflex, and free flying target discrimination-tasks. Methods to explore operant conditioning in bees and other invertebrates are not as varied as with vertebrates...
2016: PloS One
https://www.readbyqxmd.com/read/27562025/sub-lethal-effects-of-dietary-neonicotinoid-insecticide-exposure-on-honey-bee-queen-fecundity-and-colony-development
#11
Judy Wu-Smart, Marla Spivak
Many factors can negatively affect honey bee (Apis mellifera L.) health including the pervasive use of systemic neonicotinoid insecticides. Through direct consumption of contaminated nectar and pollen from treated plants, neonicotinoids can affect foraging, learning, and memory in worker bees. Less well studied are the potential effects of neonicotinoids on queen bees, which may be exposed indirectly through trophallaxis, or food-sharing. To assess effects on queen productivity, small colonies of different sizes (1500, 3000, and 7000 bees) were fed imidacloprid (0, 10, 20, 50, and 100 ppb) in syrup for three weeks...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27471279/insulin-effects-on-honeybee-appetitive-behaviour
#12
Carolina Mengoni Goñalons, Marie Guiraud, María Gabriela de Brito Sanchez, Walter M Farina
Worker honeybees (Apis mellifera) carry out multiple tasks throughout their adult lifespan. It has been suggested that the insulin/insulin-like signalling pathway participates in regulating behavioural maturation in eusocial insects. Insulin signalling increases as the honeybee worker transitions from nurse to food processor to forager. As behavioural shifts require differential usage of sensory modalities, our aim was to assess insulin effects on olfactory and gustatory responsiveness as well as on olfactory learning in preforaging honeybee workers of different ages...
October 1, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27392711/expression-analysis-of-egr-1-ortholog-in-metamorphic-brain-of-honeybee-apis-mellifera-l-possible-evolutionary-conservation-of-roles-of-egr-in-eye-development-in-vertebrates-and-insects
#13
Atsushi Ugajin, Takayuki Watanabe, Hironobu Uchiyama, Tetsuhiko Sasaki, Shunsuke Yajima, Masato Ono
Specific genes quickly transcribed after extracellular stimuli without de novo protein synthesis are known as immediate early genes (IEGs) and are thought to contribute to learning and memory processes in the mature nervous system of vertebrates. A recent study revealed that the homolog of Early growth response protein-1 (Egr-1), which is one of the best-characterized vertebrate IEGs, shared similar properties as a neural activity-dependent gene in the adult brain of insects. With regard to the roles of vertebrate Egr-1 in neural development, the contribution to the development and growth of visual systems has been reported...
September 16, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27384394/non-target-impurity-profiling-of-marketplace-cetirizine-using-high-resolution-mass-spectrometry-and-multivariate-data-analysis
#14
Zhe Zhou
RATIONALE: As always, drug impurity is the first concern of medication safety. The quality of pre- and post-marketed drugs is estimated through systematic analysis of potential hazardous substances by impurity profiling. Impurity profile is the general name of all unwanted materials which may affect the purity of an active pharmaceutical ingredient (API). The safety of original drugs is guaranteed by an enormous amount of animal experiments and clinical research while the safety of generic drugs should also be ensured by comparative analysis for consistency evaluation...
September 15, 2016: Rapid Communications in Mass Spectrometry: RCM
https://www.readbyqxmd.com/read/27307487/evidence-of-trapline-foraging-in-honeybees
#15
Alexis Buatois, Mathieu Lihoreau
Central-place foragers exploiting floral resources often use multi-destination routes (traplines) to maximise their foraging efficiency. Recent studies on bumblebees have showed how solitary foragers can learn traplines, minimising travel costs between multiple replenishing feeding locations. Here we demonstrate a similar routing strategy in the honeybee (Apis mellifera), a major pollinator known to recruit nestmates to discovered food resources. Individual honeybees trained to collect sucrose solution from four artificial flowers arranged within 10 m of the hive location developed repeatable visitation sequences both in the laboratory and in the field...
August 15, 2016: Journal of Experimental Biology
https://www.readbyqxmd.com/read/27296894/pathogenesis-of-varroosis-at-the-level-of-the-honey-bee-apis-mellifera-colony
#16
J Wegener, H Ruhnke, K Scheller, S Mispagel, U Knollmann, G Kamp, K Bienefeld
The parasitic mite Varroa destructor, in interaction with different viruses, is the main cause of honey bee colony mortality in most parts of the world. Here we studied how effects of individual-level parasitization are reflected by the bee colony as a whole. We measured disease progression in an apiary of 24 hives with differing degree of mite infestation, and investigated its relationship to 28 biometrical, physiological and biochemical indicators. In early summer, when the most heavily infested colonies already showed reduced growth, an elevated ratio of brood to bees, as well as a strong presence of phenoloxidase/prophenoloxidase in hive bees were found to be predictors of the time of colony collapse...
August 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27262427/inhibiting-dna-methylation-alters-olfactory-extinction-but-not-acquisition-learning-in-apis-cerana-and-apis-mellifera
#17
Zhiwen Gong, Chao Wang, James C Nieh, Ken Tan
DNA methylation plays a key role in invertebrate acquisition and extinction memory. Honey bees have excellent olfactory learning, but the role of DNA methylation in memory formation has, to date, only been studied in Apis mellifera. We inhibited DNA methylation by inhibiting DNA methyltransferase (DNMT) with zebularine (zeb) and studied the resulting effects upon olfactory acquisition and extinction memory in two honey bee species, Apis cerana and A. mellifera. We used the proboscis extension reflex (PER) assay to measure memory...
July 2016: Journal of Insect Physiology
https://www.readbyqxmd.com/read/27239230/badapple-promiscuity-patterns-from-noisy-evidence
#18
Jeremy J Yang, Oleg Ursu, Christopher A Lipinski, Larry A Sklar, Tudor I Oprea, Cristian G Bologa
BACKGROUND: Bioassay data analysis continues to be an essential, routine, yet challenging task in modern drug discovery and chemical biology research. The challenge is to infer reliable knowledge from big and noisy data. Some aspects of this problem are general with solutions informed by existing and emerging data science best practices. Some aspects are domain specific, and rely on expertise in bioassay methodology and chemical biology. Testing compounds for biological activity requires complex and innovative methodology, producing results varying widely in accuracy, precision, and information content...
2016: Journal of Cheminformatics
https://www.readbyqxmd.com/read/27173525/beltracker-evidence-sentence-retrieval-for-bel-statements
#19
Majid Rastegar-Mojarad, Ravikumar Komandur Elayavilli, Hongfang Liu
Biological expression language (BEL) is one of the main formal representation models of biological networks. The primary source of information for curating biological networks in BEL representation has been literature. It remains a challenge to identify relevant articles and the corresponding evidence statements for curating and validating BEL statements. In this paper, we describe BELTracker, a tool used to retrieve and rank evidence sentences from PubMed abstracts and full-text articles for a given BEL statement (per the 2015 task requirements of BioCreative V BEL Task)...
2016: Database: the Journal of Biological Databases and Curation
https://www.readbyqxmd.com/read/27126787/fusion-strategies-for-selecting-multiple-tuning-parameters-for-multivariate-calibration-and-other-penalty-based-processes-a-model-updating-application-for-pharmaceutical-analysis
#20
Alister J Tencate, John H Kalivas, Alexander J White
New multivariate calibration methods and other processes are being developed that require selection of multiple tuning parameter (penalty) values to form the final model. With one or more tuning parameters, using only one measure of model quality to select final tuning parameter values is not sufficient. Optimization of several model quality measures is challenging. Thus, three fusion ranking methods are investigated for simultaneous assessment of multiple measures of model quality for selecting tuning parameter values...
May 19, 2016: Analytica Chimica Acta
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