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Chinese herbal medicine

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https://www.readbyqxmd.com/read/29783016/systematic-investigation-of-the-erigeron-breviscapus-mechanism-for-treating-cerebrovascular-disease
#1
Jiangmei Wang, Yangyang Chen, Baoshi Liu, Qian Wang, Lulu Zhang, Zhenzhong Wang, Jun Zhou, Wei Xiao, Chunli Zheng, Yonghua Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Cerebrovascular diseases (CBVDs), characterized by striking morbidity and mortality, have become the most common life-threatening diseases. The existing drugs of CBVDs target one or a few of pathogenic factors, the efficacy of which is limited because of the complexity of CBVDs. Traditional Chinese medicine (TCM), featured by multi-component and multi-target endows the great effectiveness in CBVDs treatment. For instance, Erigeron breviscapus (vant.) Hand...
May 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29777900/material-basis-research-for-huangqi-jianzhong-tang-against-chronic-atrophic-gastritis-rats-through-integration-of-urinary-metabonomics-and-systemsdock
#2
Yuetao Liu, Wenqian Xu, GuoHong Wang, Xuemei Qin
ETHNOPHARMACOLOGICAL RELEVANCE: Huangqi Jianzhong Tang (HQJZ), a celebrated traditional Chinese medicine (TCM), is commonly used for treatment of chronic atrophic gastritis (CAG) in China. AIM OF THE STUDY: We aimed to screen out the material basis of HQJZ against CAG. MATERIALS AND METHODS: CAG rat model was constructed by alternant administrations of ammonia solution and sodium deoxycholate, and the hunger disorder method. Body weight, biochemical indexes and histopathological exam were used to evaluate the efficacy of HQJZ...
May 16, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29775121/a-cohort-study-to-examine-the-use-of-chinese-herbal-medicine-in-combination-with-conventional-therapies-for-patients-with-hepatocellular-carcinoma-in-china
#3
Lingling Sun, Paul Fahey, Xiaoshu Zhu, Weng Ng, Zhuo Ping Chen, Yiwen Qiu, Hezheng Lai, Jietao Lin, Lizhu Lin
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the major malignancies associated with high mortality rates. Chinese herbal medicine (CHM) alone, or in combination with conventional therapies (CT), has been widely used for patients with HCC in China. This study aims to explore how integrative therapy (IT) through the combination of CHM and CT affects the survival of patients with intermediate-advanced HCC. METHODS: A retrospective cohort study was performed at the First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China...
May 1, 2018: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/29773341/a-full-solution-for-multi-component-quantification-oriented-quality-assessment-of-herbal-medicines-chinese-agarwood-as-a-case
#4
Huixia Huo, Yao Liu, Wenjing Liu, Jing Sun, Qian Zhang, Yunfang Zhao, Jiao Zheng, Pengfei Tu, Yuelin Song, Jun Li
The quality of herbal medicines (HMs) is the prerequisite for their pronounced therapeutic outcomes in clinic, and multi-component (also known as quality markers, Q-markers) quantification has been widely emphasized as a viable means for quality evaluation. Because of the chemical diversity, the quality control practices are extensively dampened by four principal technical bottlenecks, including the lack of authentic compounds, large polarity span, extensive concentration range, and signal misrecognition for those potential Q-markers...
May 9, 2018: Journal of Chromatography. A
https://www.readbyqxmd.com/read/29770277/a-strategy-to-find-novel-candidate-anti-alzheimer-s-disease-drugs-by-constructing-interaction-networks-between-drug-targets-and-natural-compounds-in-medical-plants
#5
Bi-Wen Chen, Wen-Xing Li, Guang-Hui Wang, Gong-Hua Li, Jia-Qian Liu, Jun-Juan Zheng, Qian Wang, Hui-Juan Li, Shao-Xing Dai, Jing-Fei Huang
Background: Alzheimer' disease (AD) is an ultimately fatal degenerative brain disorder that has an increasingly large burden on health and social care systems. There are only five drugs for AD on the market, and no new effective medicines have been discovered for many years. Chinese medicinal plants have been used to treat diseases for thousands of years, and screening herbal remedies is a way to develop new drugs. Methods: We used molecular docking to screen 30,438 compounds from Traditional Chinese Medicine (TCM) against a comprehensive list of AD target proteins...
2018: PeerJ
https://www.readbyqxmd.com/read/29766316/influence-of-harvest-stage-on-the-pharmacological-effect-of-angelica-dahurica
#6
Wei-Hong Liang, Tung-Wu Chang, Yuh-Chyang Charng
BACKGROUND: Baizhi (Angelica dahurica) has been widely used as a traditional Chinese herbal medicine, functional food and cosmetic product ingredient, mostly because of the high furanocoumarin compounds in roots. The cropping system of Baizhi with its unique summer dormancy feature, is easily affected by the transition of its growth stages. The aim of this study was to analyze the quantity (size, form and dry weight [DW]) and quality (antioxidant and furanocoumarin content) of taproot and lateral root from three growth stages of Baizhi; vegetative (V-stage), summer dormancy (S-stage) and bolting stage (B-stage)...
May 15, 2018: Botanical Studies (Taipei, Taiwan)
https://www.readbyqxmd.com/read/29763415/efficacy-safety-and-cost-of-therapy-of-the-traditional-chinese-medicine-catalpol-in-patients-following-surgical-resection-for-locally-advanced-colon-cancer
#7
Baogang Fei, Wei Dai, Shouhe Zhao
BACKGROUND The aim of this study was to evaluate the efficacy, safety, and cost of treatment of the traditional Chinese herbal medicine, catalpol, in patients following surgical resection for locally advanced colon cancer. MATERIAL AND METHODS The 345 patients who had undergone surgical resection for locally advanced colon adenocarcinoma, were divided into three groups: a placebo-treated group (n=115); patients treated with an intraperitoneal injection of 10 mg/kg catalpol twice a day for 12 weeks (treatment group) (n=115); patients treated with 5 mg/kg intravenous bevacizumab twice a week for 12 weeks (control group) (n=115)...
May 15, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29758469/a-facile-and-selective-approach-to-the-qualitative-and-quantitative-analysis-of-triterpenoids-and-phenylpropanoids-by-uplc-q-tof-ms-ms-for-the-quality-control-of-ilex-rotunda
#8
Bao Yang, Hui Li, Qing-Feng Ruan, Yuan-Yuan Xue, Di Cao, Xing-Hong Zhou, Shi-Qin Jiang, Tao Yi, Jing Jin, Zhong-Xiang Zhao
Ilex rotunda, in which triterpenoids and phenylpropanoids are major bioactive constituents, has been widely used in traditional Chinese medicines. In this study, a validated UPLC/Q-TOF-MS/MS method was developed to simultaneously identify and quantify the triterpenoids and phenylpropanoids in the stem bark, fruit, leaves, roots and stem xylem of this herbal medicine. A total of seventy triterpenoids and twelve phenylpropanoids were identified with the assistance of the modified mass defect filter and key product ion filter data processing strategies, and forty-eight of them were confirmed by reference substances...
May 3, 2018: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29755358/therapeutic-angiogenesis-of-chinese-herbal-medicines-in-ischemic-heart-disease-a-review
#9
REVIEW
Dongqing Guo, Colin E Murdoch, Tianhua Liu, Jia Qu, Shihong Jiao, Yong Wang, Wei Wang, Xing Chen
Ischemic heart disease (IHD) is one of the primary causes of death around the world. Therapeutic angiogenesis is a promising innovative approach for treating IHD, improving cardiac function by promoting blood perfusion to the ischemic myocardium. This treatment is especially important for targeting patients that are unable to undergo angioplasty or bypass surgery. Chinese herbal medicines have been used for more than 2,500 years and they play an important role alongside contemporary medicines in China. Growing evidence in animal models show Chinese herbal medicines can provide therapeutic effect on IHD by targeting angiogenesis...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29752613/immune-homeostasis-effects-of-chinese-herbal-formulae-and-herb-derived-compounds-on-allergic-asthma-in-different-experimental-models
#10
REVIEW
Lu Liu, Lin-Peng Wang, Shan He, Yan Ma
Allergic asthma is thought to arise from an imbalance of immune regulation, which is characterized by the production of large quantities of IgE antibodies by B cells and a decrease of the interferon-γ/interleukin-4 (Th1/Th2) ratio. Certain immunomodulatory components and Chinese herbal formulae have been used in traditional herbal medicine for thousands of years. However, there are few studies performing evidence-based Chinese medicine (CM) research on the mechanisms and effificacy of these drugs in allergic asthma...
May 2018: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29752140/feiji-recipe-inhibits-the-growth-of-lung-cancer-by-modulating-t-cell-immunity-through-indoleamine-2-3-dioxygenase-pathway-in-an-orthotopic-implantation-model
#11
Bin Luo, Zu-Jun Que, Zhi-Yi Zhou, Qing Wang, Chang-Sheng Dong, Yi Jiang, Bing Hu, Hui Shi, Yu Jin, Jian-Wen Liu, He-Gen Li, Lin Wang, Jian-Hui Tian
OBJECTIVE: Escape from the body's immune response is a basic characteristic of lung cancer, and indoleamine-2,3-dioxygenase (IDO) plays a key role in mediating immune escape of non-small-cell lung cancer, which leads to recurrence and metastasis. Feiji Recipe, a compound Chinese herbal medicine, has the effect of stabilizing lesions and prolonging survival in patients with lung cancer. The purpose of this study was to investigate the mechanisms underlying the anticancer properties of Feiji Recipe...
April 22, 2018: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/29751724/-textual-research-on-origin-and-genuine-of-lilii-bulbus
#12
Chang-Hua Wang, Shu Shu, Fu-Jun Yin, Ji-Feng Zhao, Zhi-Wei Zhang, Xiang Liu, Zhi-Lai Zhan
Lilii Bulbus, which comes from many medicinal plants,is a frequently-used traditional Chinese medicine,the records in previous herbal literatures of it's origin and quality were inconstant. To trace back it's sources, we conducted a systematical study on it's origin and quality by textual research and investigation in this paper,The result showed that the origins of Lilii Bulbus are mainly source from white-flowers, red-yellow-flowers and red-flowers of Lilium, L. brownii var. viridulum, which were believed authentic or good quality in all previous herbal literatures,and L...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29751723/-study-on-medication-laws-of-tibetan-medicine-in-treatment-of-plateau-disease-based-on-data-mining-technology
#13
Huan Liu, Cai-Yun Zhao, Wen Zhang, Yi Zhang, Jia Nie
Traditional Chinese medicine inheritance support system (TCMISS, V2.5) was used in this study to analyze the common medicines, frequency of medicine combination, core herbal combinations and new prescriptions for the treatment of plateau disease from the Four-Volume Medical Code, Mannose Herbal Mirror and other related books. TCMISS V2.5 software was used to construct the database of drug treatment for plateau disease. The frequency analysis and association rules apriori algorithm, improved mutual information method and other data mining methods were used to explore the law of drug compatibility...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29751701/-changes-of-transport-sugar-content-in-different-organs-of-rehmannia-glutinosa
#14
Dong-Hui Wang, Na Liao, Peng Sun, Xue-Qi Ji, Xian-En Li, Min-Jian Qin
Raffinose series oligosaccharides are the transport and storage sugars of many plants, Rehmannia glutinosa is one of the commonly used Chinese herbal medicines, medicinal parts ist he roots. Root and tuber of R. glutinosa contains stachyose, raffinose and other oligosaccharides, but the study about the process of growth and development of other organs in the non-structural changes in sugar content is rare.In this study, leaves, stems and roots of R. glutinosa were used as materials to analyze the diurnal variation and the changes of sugar content of sucrose, raffinose and stachyose in different organs of R...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29751696/-research-of-pollution-free-and-precision-cultivation-system-of-chinese-herbal-medicines
#15
Shi-Lin Chen, Lin-Lin Dong, Qiao-Sheng Guo, Jian-He Wei, Xi-Wen Li, Gang Li, Qi Li, Yu-de Liu, Si-Jing Liu, Hong Xu, Yu-Qi Yu, Jie Wu, Chong-Heng Liang
The issues of disordering production and non-standard pesticide application are common in the production of Chinese herbal medicines. Aimed to above problems, research groups built the pollution-free and precision cultivation system of medicinal plants. This system mainly included the precise site selection of medicinal plants based on the GIS technology, modern omics-assisted breeding, metagenomics guiding the soil complex improvement, and the precise field management based on rational application of fertilizer and comprehensive control of disease...
April 2018: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
https://www.readbyqxmd.com/read/29751123/high-altitude-species-high-profits-can-the-trade-in-wild-harvested-fritillaria-cirrhosa-liliaceae-be-sustained
#16
REVIEW
A B Cunningham, J A Brinckmann, S-J Pei, P Luo, U Schippmann, X Long, Y-F Bi
ETHNOPHARMACOLOGICAL RELEVANCE: Fritillaria cirrhosa D. Don bulbs contain alkaloids and are one of the most intensively exploited alpine Himalayan medicinal species. In terms of proprietary medicines, our study shows that 210 F. cirrhosa products are offered by 46 suppliers, most of which (44) are situated in China and two in Nepal. A widepread commercial use is as one of the main ingredients in cough syrups. A well known example is "Nin Jiom Pei Pa Koa Herbal Cough & Throat Syrup", which typically contains more F...
May 8, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29750635/mechanism-research-of-bu-shen-huo-xue-formula-against-renal-fibrosis-in-rats-with-5-6-nephrectomy-via-e-cadherin-%C3%AE-sma-and-tgf-%C3%AE-1
#17
Jian-Rao Lu, Hai-Yan Han, Jing Hu, Chuan-Fu Zhang, Jie Chen, Xiu-Feng Chen, Xin-Hua Wang, Rong-Hua Pan
OBJECTIVE: Renal fibrosis generally results in renal failure during the end stage of chronic renal diseases. There are many cell factors including E-cadherin, α-SMA, and TGF-β1 influencing deposition of extracellular matrix and leading to renal fibrosis. As the most important and widely-used therapy for various diseases in China for thousands of years, traditional Chinese medicine (TCM) provides a novel treatment for renal fibrosis. For clinical application, we explore the effect of Bu-Shen-Huo-Xue formula (BSHX), a traditional Chinese herbal formula, on E-cadherin and α-SMA in rats with 5/6 nephrectomy...
May 11, 2018: Clinical Nephrology
https://www.readbyqxmd.com/read/29747755/the-potential-of-three-different-pcr-related-approaches-for-the-authentication-of-mixtures-of-herbal-substances-and-finished-herbal-medicinal-products
#18
Kirsten Doganay-Knapp, Annika Orland, Gabriele M König, Werner Knöss
BACKGROUND: Herbal substances and preparations thereof play an important role in healthcare systems worldwide. Due to the variety of these products regarding origin, composition and processing procedures, appropriate methodologies for quality assessment need to be considered. A majority of herbal substances is administered as multicomponent mixtures, especially in the field of Traditional Chinese Medicine and ayurvedic medicine, but also in finished medicinal products. Quality assessment of complex mixtures of herbal substances with conventional methods is challenging...
April 1, 2018: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
https://www.readbyqxmd.com/read/29746932/prevention-of-carcinogenesis-and-metastasis-by-artemisinin-type-drugs
#19
Mohammed L Abba, Nitin Patil, Jörg Hendrik Leupold, Mohamed E M Saeed, Thomas Efferth, Heike Allgayer
Artemisia annua (sweet wormwood, qinhao) is an ancient Chinese herbal remedy for pyrexia. Nowadays, artemisinin (qinghaosu) and its derivatives belong to the standard therapies against malaria worldwide, and its discovery has led to the Nobel Prize in Physiology and Medicine to Youyou Tu in 2015. While most attention has been paid to the treatment of malaria, there is increasing evidence that Artemisinin-type drugs bear a considerable potential to treat and prevent cancer. Rather than reporting on therapy of cancer, this review gives a comprehensive and timely overview on the chemopreventive effects of artemisinin and its derivatives against carcinogenesis and metastasis formation, following the multistage model of carcinogenesis (initiation, promotion, progression)...
May 7, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29745662/eucommia-ulmoides-oliver-a-potential-feedstock-for-bioactive-products
#20
Ming-Qiang Zhu, Run-Cang Sun
Eucommia ulmoides Oliver (EUO), a traditional Chinese herb, contains a variety of bioactive chemicals including lignans, iridoids, phenolics, steroids, terpenoids, flavonoids, etc. These bioactive chemicals possess the effective function in nourishing liver and kidney and regulating blood pressure. The composition of bioactive chemicals extracted from EUO vary to the different functional parts (leaves, seeds, bark and staminate flower) and planting models. The bioactive parts of EUO are widely utilized as raw materials for medicine and food, powdery extracts, herbal foumulations and tinctured extracts...
May 10, 2018: Journal of Agricultural and Food Chemistry
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