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Chinese herbal medicine

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https://www.readbyqxmd.com/read/27905672/oral-astragalus-huang-qi-for-preventing-frequent-episodes-of-acute-respiratory-tract-infection-in-children
#1
REVIEW
Guobin Su, Xiankun Chen, Zhuangzhu Liu, Lihong Yang, La Zhang, Cecilia Stålsby Lundborg, Zehuai Wen, Xinfeng Guo, Xindong Qin, Jueyao Liang, Xusheng Liu
BACKGROUND: Acute respiratory tract infections (ARTIs) are common in children and can involve both upper and lower airways. Many children experience frequent ARTI episodes or recurrent respiratory tract infections (RRTIs) in early life, which creates challenges for paediatricians, primary care physicians, parents and carers of children.In China, Astragalus (Huang qi), alone or in combination with other herbs, is used by Traditional Chinese Medicine (TCM) practitioners in the form of a water extract, to reduce the risk of ARTIs; it is believed to stimulate the immune system...
December 1, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27901023/rhein-and-rhubarb-similarly-protect-the-blood-brain-barrier-after-experimental-traumatic-brain-injury-via-gp91-phox-subunit-of-nadph-oxidase-ros-erk-mmp-9-signaling-pathway
#2
Yang Wang, Xuegong Fan, Tao Tang, Rong Fan, Chunhu Zhang, Zebing Huang, Weijun Peng, Pingping Gan, Xingui Xiong, Wei Huang, Xi Huang
Oxidative stress chiefly contributes to the disruption of the BBB following traumatic brain injury (TBI). The Chinese herbal medicine rhubarb is a promising antioxidant in treating TBI. Here we performed in vivo and in vitro experiments to determine whether rhubarb and its absorbed bioactive compound protected the BBB after TBI by increasing ZO-1 expression through inhibition of gp91(phox) subunit of NADPH oxidase/ROS/ERK/MMP-9 pathway. Rats were subjected to the controlled cortical impact (CCI) model, and primary rat cortical astrocytes were exposed to scratch-wound model...
November 30, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27884853/gyejibongneyong-hwan-a-herbal-medicine-for-the-treatment-of-dysmenorrhoea-with-uterine-fibroids-a-protocol-for-a-randomised-controlled-trial
#3
Jeeyoun Jung, Ju Ah Lee, Mi Mi Ko, Sooseong You, Eunhee Lee, Jiae Choi, Byoung-Kab Kang, Myeong Soo Lee
INTRODUCTION: Gyejibongneyong-hwan (GBH), or the Guizhi Fuling Formula in Chinese, is widely used to treat uterine fibroids in East Asian countries including Korea, China and Japan. This study will assess the efficacy and safety of the GBH formula for the treatment of dysmenorrhoea. METHODS AND ANALYSIS: This study will be a randomised double-blind controlled trial with two parallel arms: the GBH group and the placebo group. This trial will recruit 38 women between 18 and 45 years of age with secondary dysmenorrhoea with uterine fibroids...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27884841/herbal-medicines-for-the-treatment-of-otitis-media-with-effusion-a-systematic-review-of-randomised-controlled-trials
#4
Mi Ju Son, Songie Choi, Young-Eun Kim, Yun Hee Kim
OBJECTIVES: This systematic review aimed to assess the clinical evidence supporting the use of herbal medicines (HMs) for the treatment of otitis media with effusion (OME). DESIGN: Systematic review and meta-analysis. DATA SOURCES: MEDLINE, EMBASE, Cochrane Library, AMED, CINAHL and three trial registries were searched up to January 2015. We also searched five Korean medical databases (KoreaMed, RISS, OASIS, DBPIA and KISS) and three Chinese databases (CNKI, Wanfang and VIP)...
November 24, 2016: BMJ Open
https://www.readbyqxmd.com/read/27875972/the-role-of-chinese-herbal-medicines-and-bioactive-ingredients-targeting-myocardial-kca-and-katp-channels-in-cardiovascular-diseases
#5
Yan Dong, Pengqian Wang, Xue Feng, Bing Li, Zhong Wang, Haixia Li
Cardiovascular disorders are the most common diseases all over the world, which have limitations in the current treatment strategies. As two subtypes of potassium channel, KCa and KATP ion channels are playing important roles in the occurrence and development of cardiovascular diseases. KCa by activating the signal pathway of c-Src/PI3-kinase/Akt-dependent or eNOS-NO-cGMP affects the function of vascular endothelial cell, while KATP acting as medium combines the cell electrical activity and energy metabolism...
November 22, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27865796/bletilla-striata-medicinal-uses-phytochemistry-and-pharmacological-activities
#6
REVIEW
Xirui He, Jiacheng Fang, Xiaoxiao Wang, Zefeng Zhao, Yu Chang, Hao Guo, Linhong Huang
ETHNOPHARMACOLOGICAL RELEVANCE: Bletilla striata (Thunb.) Reichb. f. (Orchidaceae), also known as Hyacinth Orchid and Baiji (Simplified Chinese: ), not only has been widely used for the treatment of hematemesis, hemoptysis, and traumatic bleeding due to the efficacy of arresting bleeding with astringent action, but also has been applied topically to overcome ulcers, sores, swellings, and chapped skin due to the efficacy of dispersing swelling and promoting tissue regeneration. Additional medical applications include the treatment of tuberculosis, malignant ulcers, hemorrhoids, anthrax, eye diseases, and silicosis...
November 16, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27863471/tanshinone-iia-combined-with-adriamycin-inhibited-malignant-biological-behaviors-of-nsclc-a549-cell-line-in-a-synergistic-way
#7
Jun Xie, Jia-Hui Liu, Heng Liu, Xiao-Zhong Liao, Yuling Chen, Mei-Gui Lin, Yue-Yu Gu, Tao-Li Liu, Dong-Mei Wang, Hui Ge, Sui-Lin Mo
BACKGROUND: The study was designed to develop a platform to verify whether the extract of herbs combined with chemotherapy drugs play a synergistic role in anti-tumor effects, and to provide experimental evidence and theoretical reference for finding new effective sensitizers. METHODS: Inhibition of tanshinone IIA and adriamycin on the proliferation of A549, PC9 and HLF cells were assessed by CCK8 assays. The combination index (CI) was calculated with the Chou-Talalay method, based on the median-effect principle...
November 18, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27863367/prescription-pattern-of-chinese-herbal-products-for-heart-failure-in-taiwan-a-population-based-study
#8
Ming-Yen Tsai, Wen-Long Hu, Che-Chen Lin, Yi-Chiao Lee, Shih-Yu Chen, Yu-Chiang Hung, Yung-Hsiang Chen
BACKGROUND: Certain Chinese herbal products (CHPs) may protect against the progression of heart failure (HF). However, there is a lack of research regarding the use of CHPs in patients with HF. The aims of this study were to analyze CHPs usage patterns in patients with HF and to identify the frequency and combination of CHPs most commonly used for HF. METHODS: This retrospective, nationwide, population-based cohort study was conducted using a randomly sampled cohort of one million patients selected from the National Health Insurance Research Database (NHIRD) for the years 2000-2010 in Taiwan...
November 9, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27856104/the-investigation-of-anti-inflammatory-activity-of-yi-guanjian-decoction-by-serum-metabonomics-approach
#9
Sufang Shui, Xiaorong Cai, Rongqing Huang, Bingkun Xiao, Jianyun Yang
Yi Guanjian (YGJ), one of the Chinese herbal medicines most commonly used in western countries, reported to possess significant anti-inflammatary effects that inhibit the process of inflammation. However, the mechanisms underlying its anti-inflammation effects remain largely unresolved. This study was aimed to investigate the anti-inflammatory activity of YGJ and to explore its potential anti-inflammatory mechanisms by serum metabonomics approach. An xylene-induced mouse right-ear-edema model was used as an inflammatory response in vivo model...
January 30, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27855662/microarray-expression-profile-analysis-of-mrnas-and-long-non-coding-rnas-in-pulmonary-tuberculosis-with-different-traditional-chinese-medicine-syndromes
#10
Ting-Ting Jiang, Li-Liang Wei, Li-Ying Shi, Zhong-Liang Chen, Chong Wang, Chang-Ming Liu, Zhong-Jie Li, Ji-Cheng Li
BACKGROUND: Combination chemotherapy with Western anti-tuberculosis (TB) drugs is the mainstay of TB treatment. Chinese herbal medicines with either heat clearing and detoxifying effects or nourishing Yin and reducing fire effects have been used to treat TB based on the Traditional Chinese Medicine (TCM) syndromes of TB patients. This study analyzed the expression profiles of long non-coding RNAs (lncRNAs) and mRNAs in TB patients with different TCM syndromes. METHODS: TB patients were classified as pulmonary Yin deficiency (PYD) syndrome, hyperactivity of fire due to Yin deficiency (HFYD) syndrome, and deficiency of Qi and Yin (DQY) syndrome...
November 17, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27855368/triggering-of-erythrocyte-cell-membrane-scrambling-by-emodin
#11
Morena Mischitelli, Mohamed Jemaà, Mustafa Almasry, Caterina Faggio, Florian Lang
BACKGROUND/AIMS: The natural anthraquinone derivative emodin (1,3,8-trihydroxy-6-methylanthraquinone) is a component of several Chinese medicinal herbal preparations utilized for more than 2000 years. The substance has been used against diverse disorders including malignancy, inflammation and microbial infection. The substance is effective in part by triggering suicidal death or apoptosis. Similar to apoptosis of nucleated cells erythrocytes may enter suicidal erythrocyte death or eryptosis, characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine translocation to the erythrocyte surface...
2016: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/27853254/gastrodin-protects-against-chronic-inflammatory-pain-by-inhibiting-spinal-synaptic-potentiation
#12
Mei-Mei Xiao, Yu-Qi Zhang, Wen-Ting Wang, Wen-Juan Han, Zhen Lin, Rou-Gang Xie, Zhi Cao, Na Lu, San-Jue Hu, Sheng-Xi Wu, Hui Dong, Ceng Luo
Tissue injury is known to produce inflammation and pain. Synaptic potentiation between peripheral nociceptors and spinal lamina I neurons has been proposed to serve as a trigger for chronic inflammatory pain. Gastrodin is a main bioactive constituent of the traditional Chinese herbal medicine Gastrodia elata Blume, which has been widely used as an analgesic since ancient times. However, its underlying cellular mechanisms have remained elusive. The present study demonstrated for the first time that gastrodin exhibits an analgesic effect at the spinal level on spontaneous pain, mechanical and thermal pain hypersensitivity induced by peripheral inflammation, which is not dependent on opioid receptors and without tolerance...
November 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27852305/schisandra-polysaccharide-inhibits-hepatic-lipid-accumulation-by-downregulating-expression-of-srebps-in-nafld-mice
#13
Chun-Mei Wang, Rong-Shuang Yuan, Wen-Yue Zhuang, Jing-Hui Sun, Jin-Ying Wu, He Li, Jian-Guang Chen
BACKGROUND: Hepatoprotective effects of Chinese herbal medicine Schisandra Chinensis (Schisandra) have been widely investigated. However, most studies were focused on its lignan extracts. We investigated the effects of Schisandra polysaccharide (SCP) in a mouse model of non-alcoholic fatty liver disease (NAFLD), and studied its effect on sterol regulatory element binding proteins (SREBPs) and the related genes. METHODS: The mouse model of NAFLD was established by feeding mice with a high-fat diet for 16 weeks...
November 16, 2016: Lipids in Health and Disease
https://www.readbyqxmd.com/read/27848250/pharmacological-effects-of-active-components-of-chinese-herbal-medicine-in-the-treatment-of-alzheimer-s-disease-a-review
#14
Zhi-Yong Wang, Jian-Gang Liu, Hao Li, Hui-Ming Yang
Alzheimer's disease (AD), the most common neurodegenerative disorder associated with dementia, not only severely decreases the quality of life for its victims, but also brings a heavy economic burden to the family and society. Unfortunately, few chemical drugs designed for clinical applications have reached the expected preventive or therapeutic effect so far, and combined with their significant side-effects, there is therefore an urgent need for new strategies to be developed for AD treatment. Traditional Chinese Medicine has accumulated many experiences in the treatment of dementia during thousands of years of practice; modern pharmacological studies have confirmed the therapeutic effects of many active components derived from Chinese herbal medicines (CHM)...
November 16, 2016: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27846348/pharmacological-treatment-other-than-corticosteroids-intravenous-immunoglobulin-and-plasma-exchange-for-guillain-barr%C3%A3-syndrome
#15
REVIEW
Jane Pritchard, Richard Ac Hughes, Robert Dm Hadden, Ruth Brassington
BACKGROUND: Plasma exchange and intravenous immunoglobulin, but not corticosteroids, are beneficial in Guillain-Barré syndrome (GBS). The efficacy of other pharmacological agents is unknown. This review was first published in 2011 and updated in 2013 and 2016. OBJECTIVES: To assess the effects of pharmacological agents other than plasma exchange, intravenous immunoglobulin and corticosteroids for GBS. SEARCH METHODS: On 18 January 2016, we searched the Cochrane Neuromuscular Specialised Register, Cochrane Central Register of Controlled Trials, MEDLINE, and Embase for treatments for GBS...
November 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27843317/effect-of-yi-nao-jie-yu-decoction-on-%C3%AE-aminobutyric-acid-type-a-receptor-in-the-hippocampus-and-serum-inflammatory-factors-in-a-rat-model-of-poststroke-anxiety
#16
Wen Zhang, Ruizhen Zhao, Xiaoli Li, Xia Cui, Zijun Zhao, Yingqiu Mao, Fengzhi Wu, Qisheng Tang
BACKGROUND: The Yi-nao-jie-yu decoction (YNJYD) is a herbal preparation widely used in the clinics of traditional Chinese medicine and has been recently used as an important new therapeutic agent in poststroke anxiety (PSA). The neuroendocrine-immune system plays an important role in PSA mechanisms, although the modulating effects of YNJYD remain unknown. This study investigated the potential effects of YNJYD on the neuroendocrine-immune system in a rat model of PSA. MATERIALS AND METHODS: The PSA model was induced by injecting collagenase (type VII) into the right globus pallidus, accompanied by empty water bottle stimulation for 2 weeks...
2016: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/27843296/evaluating-the-cytotoxic-effects-of-the-water-extracts-of-four-anticancer-herbs-against-human-malignant-melanoma-cells
#17
Binbing Ling, Deborah Michel, Meena Kishore Sakharkar, Jian Yang
Malignant melanoma (MM) is the most dangerous type of skin cancer, killing more than 1,100 people each year in Canada. Prognosis for late stage and recurrent MM is extremely poor due to insensitivity to chemotherapy drugs, and thus many patients seek complementary and alternative medicines. In this study, we examined four commonly used anticancer herbs in traditional Chinese medicine, Hedyotis diffusa, Scutellaria barbata, Lobelia chinensis, and Solanum nigrum, for their in vitro antitumor effects toward human MM cell line A-375...
2016: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/27842538/the-modified-gingyo-san-a-chinese-herbal-medicine-has-direct-antibacterial-effects-against-respiratory-pathogens
#18
Tetsuya Yamada, Takeaki Wajima, Hidemasa Nakaminami, Kaho Kobayashi, Hideaki Ikoshi, Norihisa Noguchi
BACKGROUND: Modified Gingyo-san (MGS) is empirically used to treat various respiratory infections. MGS has been reported to have antiinflammatory and antiviral activities; however, it is not known if it has an antibacterial activity. Therefore, in this study, we aimed to investigate the antimicrobial activity of MGS against respiratory pathogens. METHODS: MGS, which is sold as an over-the-counter drug in Japan, was used for the study. Antimicrobial activity was evaluated using the disk diffusion method...
November 14, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27832784/antitussive-anti-pyretic-and-toxicological-evaluation-of-ma-xing-gan-shi-tang-in-rodents
#19
Yu-Chin Lin, Ching-Wen Chang, Chi-Rei Wu
BACKGROUND: Ma-Xing-Gan-Shi-Tang (abbreviated as MXGST), an important Chinese herbal prescribed for cough, bronchial inflammation and fever from pneumonia, consists of four medicinal herbs, including Ephedrae herb, Semen Pruni Armeniacae, licorice and Gypsum. These components, especially Ephedrae and Semen Pruni Armeniacae, possess antitussive activities, but they have severe adverse effects. METHODS: The pharmacological activities of MXGST extract in clinical use were investigated with citric acid-induced cough, acetylcholine/histamine-induced bronchial contraction and lipopolysaccharide (LPS)-induced fever in rodents...
November 10, 2016: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/27827969/comparative-analysis-of-the-effects-of-hydroxysafflor-yellow-a-and-anhydrosafflor-yellow-b-in-safflower-series-of-herb-pairs-using-prep-hplc-and-a-selective-knock-out-approach
#20
Cheng Qu, Lin-Yan Wang, Wen-Tao Jin, Yu-Ping Tang, Yi Jin, Xu-Qin Shi, Li-Li Shang, Er-Xin Shang, Jin-Ao Duan
The flower of Carthamus tinctorius L. (Carthami Flos, safflower), important in traditional Chinese medicine (TCM), is known for treating blood stasis, coronary heart disease, hypertension, and cerebrovascular disease in clinical and experimental studies. It is widely accepted that hydroxysafflor yellow A (HSYA) and anhydrosafflor yellow B (ASYB) are the major bioactive components of many formulae comprised of safflower. In this study, selective knock-out of target components such as HSYA and ASYB by using preparative high performance liquid chromatography (prep-HPLC) followed by antiplatelet and anticoagulation activities evaluation was used to investigate the roles of bioactive ingredients in safflower series of herb pairs...
November 6, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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