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Mona Dixon Gundersen, Rasmus Goll, Johanna Hol, Trine Olsen, Renathe Rismo, Sveinung W Sørbye, Olav Sundnes, Guttorm Haraldsen, Jon Florholmen
Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer look at IL-33 expression in well-defined clinical stages of UC. A total of 50 study participants (29 UC patients and 21 healthy controls) were included from a prospective cohort of inflammatory bowel disease patients treated to disease remission with infliximab, a tumour necrosis factor alpha (TNF) inhibitor...
October 17, 2016: Scientific Reports
Rafaela Bicalho Viana Macedo, Adriana Maria Kakehasi, Marcus Vinicius Melo de Andrade
A better understanding of the inflammatory mechanisms of rheumatoid arthritis and the development of biological therapy revolutionized its treatment, enabling an interference in the synovitis - structural damage - functional disability cycle. Interleukin 33 was recently described as a new member of the interleukin-1 family, whose common feature is its pro-inflammatory activity. Its involvement in the pathogenesis of a variety of diseases, including autoimmune diseases, raises the interest in the possible relationship with rheumatoid arthritis...
September 2016: Revista Brasileira de Reumatologia
T L Croston, A P Nayak, A R Lemons, W T Goldsmith, J K Gu, D R Germolec, D H Beezhold, B J Green
BACKGROUND: Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. OBJECTIVE: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia...
October 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
Claire Galand, Juan Manuel Leyva-Castillo, Juhan Yoon, Alex Han, Margaret S Lee, Andrew N J McKenzie, Michael Stassen, Michiko K Oyoshi, Fred D Finkelman, Raif S Geha
BACKGROUND: Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in patients with MC-dependent food anaphylaxis is unknown. OBJECTIVE: We sought to determine the role and mechanism of action of IL-33 in patients with food-induced anaphylaxis in a model of IgE-dependent food anaphylaxis elicited by oral challenge of epicutaneously sensitized mice...
June 2, 2016: Journal of Allergy and Clinical Immunology
Natalia Garay-Lugo, Aarón Domínguez-Lopez, Angel Miliar García, Eliud Aguilar Barrera, Modesto Gómez López, Alejandro Gómez Alcalá, Maria de Los Angeles Martínez Godinez, Eleazar Lara-Padilla
CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. OBJECTIVE: Evaluate the effect of a high-fat or high-fat/fructose diet with and without n-3-PUFAs on hepatic gene expression. MATERIALS AND METHODS: We examined the mRNA expression by RT-PCR of Mtor, Nlrp3, and other 22 genes associated with inflammation in rats livers after a 9-week diet...
October 2016: Immunopharmacology and Immunotoxicology
Thierry Olivry, David Mayhew, Judy S Paps, Keith E Linder, Carlos Peredo, Deepak Rajpal, Hans Hofland, Javier Cote-Sierra
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR...
October 2016: Journal of Investigative Dermatology
Gregory Noel, Muhammad Imran Arshad, Aveline Filliol, Valentine Genet, Michel Rauch, Catherine Lucas-Clerc, Agnès Lehuen, Jean-Philippe Girard, Claire Piquet-Pellorce, Michel Samson
The IL-33/ST2 axis plays a protective role in T-cell-mediated hepatitis, but little is known about the functional impact of endogenous IL-33 on liver immunopathology. We used IL-33-deficient mice to investigate the functional effect of endogenous IL-33 in concanavalin A (Con A)-hepatitis. IL-33(-/-) mice displayed more severe Con A liver injury than wild-type (WT) mice, consistent with a hepatoprotective effect of IL-33. The more severe hepatic injury in IL-33(-/-) mice was associated with significantly higher levels of TNF-α and IL-1β and a larger number of NK cells infiltrating the liver...
August 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
Juan Fu, Shi-Hui Lin, Chuan-Jiang Wang, Sheng-Yuan Li, Xuan-Yun Feng, Qiong Liu, Fang Xu
The development and progression of acute respiratory distress syndrome (ARDS) has been shown to be regulated by cytokines. IL-33 and HMGB1 are conventionally considered as nuclear proteins and have a proinflammatory role. Studies have confirmed that HMGB1 has a significant role in ARDS, but few studies have provided direct evidence to confirm that IL33 is involved in ARDS. The purpose of our study was to determine whether IL-33 is elevated in ARDS and the relationship between IL-33 and HMGB1 in ARDS. We established a mouse model of LPS-induced lung inflammation/injury...
September 2016: International Immunopharmacology
Andrea Marzullo, Francesca Ambrosi, Mirjam Inchingolo, Fabio Manca, Fiorella Devito, Domenico Angiletta, Annapaola Zito, Pietro Scicchitano, Marco Matteo Ciccone
BACKGROUND: ST2 (suppression of tumorigenity) has been described as a receptor for the interleukin-33, a member of the IL-1 family of cytokines. It is associated to coronary artery disease, all-causes mortality and cardiovascular mortality. AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms...
2016: PloS One
Mezbah U Faruque, Guanjie Chen, Ayo P Doumatey, Jie Zhou, Hanxia Huang, Daniel Shriner, Adebowale A Adeyemo, Charles N Rotimi, Georgia M Dunston
OBJECTIVE: Transferability of significantly associated loci or GWAS "hits" adds credibility to genotype-disease associations and provides evidence for generalizability across different ancestral populations. We sought evidence of association of known asthma-associated single nucleotide polymorphisms (SNPs) in an African American population. METHODS: Subjects comprised 661 participants (261 asthma cases and 400 controls) from the Howard University Family Study. Forty-eight SNPs previously reported to be associated with asthma by GWAS were selected for testing...
May 13, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Rafaela Bicalho Viana Macedo, Adriana Maria Kakehasi, Marcus Vinicius Melo de Andrade
A better understanding of the inflammatory mechanisms of rheumatoid arthritis and the development of biological therapy revolutionized its treatment, enabling an interference in the synovitis-structural damage-functional disability cycle. Interleukin 33 was recently described as a new member of the interleukin-1 family, whose common feature is its pro-inflammatory activity. Its involvement in the pathogenesis of a variety of diseases, including autoimmune diseases, raises the interest in the possible relationship with rheumatoid arthritis...
March 22, 2016: Revista Brasileira de Reumatologia
Chloé Sarnowski, Pierre-Emmanuel Sugier, Raquel Granell, Debbie Jarvis, Marie-Hélène Dizier, Markus Ege, Medea Imboden, Catherine Laprise, Elza K Khusnutdinova, Maxim B Freidin, William O C Cookson, Miriam Moffatt, Mark Lathrop, Valérie Siroux, Ludmila M Ogorodova, Alexandra S Karunas, Alan James, Nicole M Probst-Hensch, Erika von Mutius, Isabelle Pin, Manolis Kogevinas, A John Henderson, Florence Demenais, Emmanuelle Bouzigon
BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques...
April 6, 2016: Journal of Allergy and Clinical Immunology
Yu Zhang, Celestia Davis, Sapana Shah, Daniel Hughes, James C Ryan, Diego Altomare, Maria Marjorette O Peña
Liver metastasis is the major cause of death from colorectal cancer (CRC). Understanding its mechanisms is necessary for timely diagnosis and development of effective therapies. Interleukin-33 (IL-33) is an IL-1 cytokine family member that uniquely functions as a cytokine and nuclear factor. It is released by necrotic epithelial cells and activated innate immune cells, functioning as an alarmin or an early danger signal. Its role in invoking type 2 immune response has been established; however, it has contrasting roles in tumor development and metastasis...
April 27, 2016: Molecular Carcinogenesis
D P E Margiotta, L Navarini, M Vadacca, M Lo Vullo, F Pignataro, F Basta, A Afeltra
OBJECTIVE: Primary Sjogren's Syndrome (pSS) is a systemic autoimmune disorder characterized by infiltration of the exocrine glands leading to secretory insufficiency. Despite the progress made in understanding the pathogenesis of the SS, many aspects remain to be clarified. Interleukin-33 (IL33) is a recently discovered cytokine, belonging to IL-1 superfamily. IL33 and its soluble receptor ST2 were implied in a number of immune and in autoimmune diseases pathogenesis. In this work ,we analyzed expression of IL33 and ST2 in Sjogren's syndrome...
April 2016: European Review for Medical and Pharmacological Sciences
Wei-Yu Chen, Ya-Jen Chang, Chia-Hao Su, Tzu-Hsien Tsai, Shang-Der Chen, Chung-Hsi Hsing, Jenq-Lin Yang
Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflammatory responses. The regulation and function of IL-33 in renal injury, however, is not well understood. To investigate the involvement of cytokines in the pathogenesis of renal injury and fibrosis, we performed the mouse renal injury model induced by unilateral urinary obstruction (UUO) and analyze the differentially upregulated genes between the obstructed and the contralateral unobstructed kidneys using RNA sequencing (RNAseq)...
May 13, 2016: Biochemical and Biophysical Research Communications
Bobby W S Li, Marjolein J W de Bruijn, Irma Tindemans, Melanie Lukkes, Alex KleinJan, Henk C Hoogsteden, Rudi W Hendriks
Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to study the induction of ILC2s in allergic airway inflammation. In BALF, lungs, and lymph nodes, ILC2 activation is critically dependent on prior sensitization with HDM. Importantly, T cells are required for ILC2 induction, whereby T-cell activation precedes ILC2 induction...
June 2016: European Journal of Immunology
Emilie Lavoie-Charland, Jean-Christophe Bérubé, Louis-Philippe Boulet, Yohan Bossé
OBJECTIVE: Genome-wide association studies (GWAS) identified single nucleotide polymorphisms (SNPs) reproducibly associated with asthma. This study evaluated whether GWAS-nominated SNPs are more strongly associated with asthma patients sharing the same clinical characteristics in order to refine the role of recently identified genes. METHODS: Analyses were performed in unrelated French Canadian subjects (566 cases and 416 controls) with data collected on lung function, blood cell counts, atopy, disease history and medication...
November 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
Jatin Patel, Ho Yi Wong, Weili Wang, Josue Alexis, Abbas Shafiee, Alexander J Stevenson, Brian Gabrielli, Nicholas M Fisk, Kiarash Khosrotehrani
Since the discovery of endothelial colony forming cells (ECFC), there has been significant interest in their therapeutic potential to treat vascular injuries. ECFC cultures display significant heterogeneity and a hierarchy among cells able to give rise to high proliferative versus low proliferative colonies. Here we aimed to define molecularly this in vitro hierarchy. Based on flow cytometry, CD34 expression levels distinguished two populations. Only CD34 + ECFC had the capacity to reproduce high proliferative potential (HPP) colonies on replating, whereas CD34- ECFCs formed only small clusters...
April 2016: Stem Cells
Ionel Sandovici, Constanze M Hammerle, Wendy N Cooper, Noel H Smith, Jane L Tarry-Adkins, Benjamin J Dunmore, Julien Bauer, Simon R Andrews, Giles S H Yeo, Susan E Ozanne, Miguel Constância
AIMS/HYPOTHESIS: Ageing is a major risk factor for development of metabolic diseases such as type 2 diabetes. Identification of the mechanisms underlying this association could help to elucidate the relationship between age-associated progressive loss of metabolic health and development of type 2 diabetes. We aimed to determine molecular signatures during ageing in the endocrine pancreas. METHODS: Global gene transcription was measured in pancreatic islets isolated from young and old rats by Ilumina BeadChip arrays...
March 2016: Diabetologia
Rui Li, Gang Yang, Ruiqi Yang, Xiaoxing Peng, Jing Li
IL33/ST2 axis activates airway eosinophils that exacerbate airway inflammation. The data was obtained from PubMed, EMBASE, Clinical trial, Cochrane Library, Web of science, CNKI and Wanfang database with time restrictions of 1 Jan, 2000 to 15 Feb, 2016. The meta-analysis was performed using Review Manager 5.2 software. After searching, total 15 documents were included into this meta-analysis, involving in 633 asthma patients and 379 healthy people. The meta-analysis results revealed that the serum IL33 or ST2 level was higher in asthma patients compared to that in healthy people...
2015: International Journal of Clinical and Experimental Medicine
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