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IL33

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https://www.readbyqxmd.com/read/27899395/functional-definition-of-progenitors-versus-mature-endothelial-cells-reveals-key-soxf-dependent-differentiation-process
#1
Jatin Patel, Elke J Seppanen, Mathieu P Rodero, Ho Yi Wong, Prudence Donovan, Zoltan Neufeld, Nicholas M Fisk, Mathias François, Kiarash Khosrotehrani
BACKGROUND: -During adult life, blood vessel formation is thought to occur via angiogenic processes involving branching from existing vessels. An alternate proposal suggests that neo-vessels form from endothelial progenitors able to assemble the intimal layers. We here aimed to define vessel-resident endothelial progenitors in vivo in a variety of tissues in physiological and pathological situations such as normal aorta, lungs, as well as wound healing, tumors and placenta. METHODS: -Based on protein expression levels of common endothelial markers using flow cytometry, three sub-populations of endothelial cells could be identified among VE-Cadherin+ and CD45- cells...
November 29, 2016: Circulation
https://www.readbyqxmd.com/read/27865862/impaired-mucus-clearance-exacerbates-allergen-induced-type-2-airway-inflammation-in-juvenile-mice
#2
Benedikt Fritzsching, Matthias Hagner, Lu Dai, Sandra Christochowitz, Raman Agrawal, Charlotte van Bodegom, Simone Schmidt, Jolanthe Schatterny, Stephanie Hirtz, Ryan Brown, Michelle Goritzka, Julia Duerr, Zhe Zhou-Suckow, Marcus A Mall
BACKGROUND: Type 2 airway inflammation plays a central role in the pathogenesis of allergen-induced asthma, but the underlying mechanisms remain poorly understood. We recently demonstrated that reduced mucociliary clearance, a characteristic feature of asthma, produces spontaneous type 2 airway inflammation in juvenile Scnn1b-transgenic (Scnn1b-Tg) mice. OBJECTIVE: To determine the role of impaired mucus clearance in the pathogenesis of allergen-induced type 2 airway inflammation and identify cellular sources of the signature cytokine IL-13...
November 16, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27826297/lipopolysaccharide-attenuates-induction-of-proallergic-cytokines-thymic-stromal-lymphopoietin-and-interleukin-33-in-respiratory-epithelial-cells-stimulated-with-polyi-c-and-human-parechovirus
#3
Tsang-Hsiung Lin, Chih-Chi Cheng, Hsing-Hao Su, Nan-Chieh Huang, Jih-Jung Chen, Hong-Yo Kang, Tsung-Hsien Chang
Epidemiological studies based on the "hygiene hypothesis" declare that the level of childhood exposure to environmental microbial products is inversely related to the incidence of allergic diseases in later life. Multiple types of immune cell-mediated immune regulation networks support the hygiene hypothesis. Epithelial cells are the first line of response to microbial products in the environment and bridge the innate and adaptive immune systems; however, their role in the hygiene hypothesis is unknown. To demonstrate the hygiene hypothesis in airway epithelial cells, we examined the effect of lipopolysaccharide (LPS; toll-like receptor 4 ligand) on the expression of the proallergic cytokines thymic stromal lymphopoietin (TSLP) and interleukin 33 (IL33) in H292 cells (pulmonary mucoepidermoid carcinoma cells)...
2016: Frontiers in Immunology
https://www.readbyqxmd.com/read/27775548/il-33-regulates-the-iga-microbiota-axis-to-restrain-il-1%C3%AE-dependent-colitis-and-tumorigenesis
#4
Ankit Malik, Deepika Sharma, Qifan Zhu, Rajendra Karki, Clifford S Guy, Peter Vogel, Thirumala-Devi Kanneganti
Inflammatory bowel diseases (IBD) affect over 5 million individuals in the industrialized world, with an increasing incidence rate worldwide. IBD also predisposes affected individuals to development of colorectal cancer, which is a leading cause of cancer-related deaths in adults. Mutations in genes encoding molecules in the IL-33 signaling pathway are associated with colitis and colitis-associated cancer (CAC), but how IL-33 modulates gut homeostasis is unclear. Here, we have shown that Il33-deficient mice are highly susceptible to colitis and CAC...
December 1, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27748438/loss-of-interleukin-33-expression-in-colonic-crypts-a-potential-marker-for-disease-remission-in-ulcerative-colitis
#5
Mona Dixon Gundersen, Rasmus Goll, Johanna Hol, Trine Olsen, Renathe Rismo, Sveinung W Sørbye, Olav Sundnes, Guttorm Haraldsen, Jon Florholmen
Interleukin 33 (IL-33) is a cytokine preferentially elevated in acute ulcerative colitis (UC), inferring a role in its pathogenesis. The role of IL-33 in intestinal inflammation is incompletely understood, with both pro-inflammatory and regulatory properties described. There are also conflicting reports on cellular sources and subcellular location of IL-33 in the colonic mucosa, justifying a closer look at IL-33 expression in well-defined clinical stages of UC. A total of 50 study participants (29 UC patients and 21 healthy controls) were included from a prospective cohort of inflammatory bowel disease patients treated to disease remission with infliximab, a tumour necrosis factor alpha (TNF) inhibitor...
October 17, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27692395/il33-in-rheumatoid-arthritis-potential-contribution-to-pathogenesis
#6
Rafaela Bicalho Viana Macedo, Adriana Maria Kakehasi, Marcus Vinicius Melo de Andrade
A better understanding of the inflammatory mechanisms of rheumatoid arthritis and the development of biological therapy revolutionized its treatment, enabling an interference in the synovitis - structural damage - functional disability cycle. Interleukin 33 was recently described as a new member of the interleukin-1 family, whose common feature is its pro-inflammatory activity. Its involvement in the pathogenesis of a variety of diseases, including autoimmune diseases, raises the interest in the possible relationship with rheumatoid arthritis...
September 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27473664/influence-of-aspergillus-fumigatus-conidia-viability-on-murine-pulmonary-microrna-and-mrna-expression-following-subchronic-inhalation-exposure
#7
T L Croston, A P Nayak, A R Lemons, W T Goldsmith, J K Gu, D R Germolec, D H Beezhold, B J Green
BACKGROUND: Personal exposure to fungal bioaerosols derived from contaminated building materials or agricultural commodities may induce or exacerbate a variety of adverse health effects. The genomic mechanisms that underlie pulmonary immune responses to fungal bioaerosols have remained unclear. OBJECTIVE: The impact of fungal viability on the pulmonary microRNA and messenger RNA profiles that regulate murine immune responses was evaluated following subchronic inhalation exposure to Aspergillus fumigatus conidia...
October 2016: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27372570/il-33-promotes-food-anaphylaxis-in-epicutaneously-sensitized-mice-by-targeting-mast-cells
#8
Claire Galand, Juan Manuel Leyva-Castillo, Juhan Yoon, Alex Han, Margaret S Lee, Andrew N J McKenzie, Michael Stassen, Michiko K Oyoshi, Fred D Finkelman, Raif S Geha
BACKGROUND: Cutaneous exposure to food allergens predisposes to food allergy, which is commonly associated with atopic dermatitis (AD). Levels of the epithelial cytokine IL-33 are increased in skin lesions and serum of patients with AD. Mast cells (MCs) play a critical role in food-induced anaphylaxis and express the IL-33 receptor ST2. The role of IL-33 in patients with MC-dependent food anaphylaxis is unknown. OBJECTIVE: We sought to determine the role and mechanism of action of IL-33 in patients with food-induced anaphylaxis in a model of IgE-dependent food anaphylaxis elicited by oral challenge of epicutaneously sensitized mice...
November 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27367537/n-3-fatty-acids-modulate-the-mrna-expression-of-the-nlrp3-inflammasome-and-mtor-in-the-liver-of-rats-fed-with-high-fat-or-high-fat-fructose-diets
#9
Natalia Garay-Lugo, Aarón Domínguez-Lopez, Angel Miliar García, Eliud Aguilar Barrera, Modesto Gómez López, Alejandro Gómez Alcalá, Maria de Los Angeles Martínez Godinez, Eleazar Lara-Padilla
CONTEXT: There is evidence that n-3 polyunsaturated fatty acids (n-3-PUFAs) can inhibit mTORC1, which should potentiate autophagy and eliminate NLRP3 inflammasome activity. OBJECTIVE: Evaluate the effect of a high-fat or high-fat/fructose diet with and without n-3-PUFAs on hepatic gene expression. MATERIALS AND METHODS: We examined the mRNA expression by RT-PCR of Mtor, Nlrp3, and other 22 genes associated with inflammation in rats livers after a 9-week diet...
October 2016: Immunopharmacology and Immunotoxicology
https://www.readbyqxmd.com/read/27342734/early-activation-of-th2-th22-inflammatory-and-pruritogenic-pathways-in-acute-canine-atopic-dermatitis-skin-lesions
#10
Thierry Olivry, David Mayhew, Judy S Paps, Keith E Linder, Carlos Peredo, Deepak Rajpal, Hans Hofland, Javier Cote-Sierra
Determining inflammation and itch pathway activation in patients with atopic dermatitis (AD) is fraught with the inability to precisely assess the age of skin lesions, thus affecting the analysis of time-dependent mediators. To characterize inflammatory events occurring during early experimental acute AD lesions, biopsy samples were collected 6, 24, and 48 hours after epicutaneous application of Dermatophagoides farinae house dust mites to sensitized atopic dogs. The skin transcriptome was assessed using a dog-specific microarray and quantitative PCR...
October 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27340126/ablation-of-interaction-between-il-33-and-st2-regulatory-t-cells-increases-immune-cell-mediated-hepatitis-and-activated-nk-cell-liver-infiltration
#11
Gregory Noel, Muhammad Imran Arshad, Aveline Filliol, Valentine Genet, Michel Rauch, Catherine Lucas-Clerc, Agnès Lehuen, Jean-Philippe Girard, Claire Piquet-Pellorce, Michel Samson
The IL-33/ST2 axis plays a protective role in T-cell-mediated hepatitis, but little is known about the functional impact of endogenous IL-33 on liver immunopathology. We used IL-33-deficient mice to investigate the functional effect of endogenous IL-33 in concanavalin A (Con A)-hepatitis. IL-33(-/-) mice displayed more severe Con A liver injury than wild-type (WT) mice, consistent with a hepatoprotective effect of IL-33. The more severe hepatic injury in IL-33(-/-) mice was associated with significantly higher levels of TNF-α and IL-1β and a larger number of NK cells infiltrating the liver...
August 1, 2016: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/27318792/hmgb1-regulates-il-33-expression-in-acute-respiratory-distress-syndrome
#12
Juan Fu, Shi-Hui Lin, Chuan-Jiang Wang, Sheng-Yuan Li, Xuan-Yun Feng, Qiong Liu, Fang Xu
The development and progression of acute respiratory distress syndrome (ARDS) has been shown to be regulated by cytokines. IL-33 and HMGB1 are conventionally considered as nuclear proteins and have a proinflammatory role. Studies have confirmed that HMGB1 has a significant role in ARDS, but few studies have provided direct evidence to confirm that IL33 is involved in ARDS. The purpose of our study was to determine whether IL-33 is elevated in ARDS and the relationship between IL-33 and HMGB1 in ARDS. We established a mouse model of LPS-induced lung inflammation/injury...
September 2016: International Immunopharmacology
https://www.readbyqxmd.com/read/27223112/st2l-transmembrane-receptor-expression-an-immunochemical-study-on-endarterectomy-samples
#13
Andrea Marzullo, Francesca Ambrosi, Mirjam Inchingolo, Fabio Manca, Fiorella Devito, Domenico Angiletta, Annapaola Zito, Pietro Scicchitano, Marco Matteo Ciccone
BACKGROUND: ST2 (suppression of tumorigenity) has been described as a receptor for the interleukin-33, a member of the IL-1 family of cytokines. It is associated to coronary artery disease, all-causes mortality and cardiovascular mortality. AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms...
2016: PloS One
https://www.readbyqxmd.com/read/27177148/transferability-of-genome-wide-associated-loci-for-asthma-in-african-americans
#14
Mezbah U Faruque, Guanjie Chen, Ayo P Doumatey, Jie Zhou, Hanxia Huang, Daniel Shriner, Adebowale A Adeyemo, Charles N Rotimi, Georgia M Dunston
OBJECTIVE: Transferability of significantly associated loci or GWAS "hits" adds credibility to genotype-disease associations and provides evidence for generalizability across different ancestral populations. We sought evidence of association of known asthma-associated single nucleotide polymorphisms (SNPs) in an African American population. METHODS: Subjects comprised 661 participants (261 asthma cases and 400 controls) from the Howard University Family Study. Forty-eight SNPs previously reported to be associated with asthma by GWAS were selected for testing...
May 13, 2016: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/27156116/il33-in-rheumatoid-arthritis-potencial-contribution-to-pathogenesis
#15
Rafaela Bicalho Viana Macedo, Adriana Maria Kakehasi, Marcus Vinicius Melo de Andrade
A better understanding of the inflammatory mechanisms of rheumatoid arthritis and the development of biological therapy revolutionized its treatment, enabling an interference in the synovitis-structural damage-functional disability cycle. Interleukin 33 was recently described as a new member of the interleukin-1 family, whose common feature is its pro-inflammatory activity. Its involvement in the pathogenesis of a variety of diseases, including autoimmune diseases, raises the interest in the possible relationship with rheumatoid arthritis...
March 22, 2016: Revista Brasileira de Reumatologia
https://www.readbyqxmd.com/read/27130862/identification-of-a-new-locus-at-16q12-associated-with-time-to-asthma-onset
#16
Chloé Sarnowski, Pierre-Emmanuel Sugier, Raquel Granell, Debbie Jarvis, Marie-Hélène Dizier, Markus Ege, Medea Imboden, Catherine Laprise, Elza K Khusnutdinova, Maxim B Freidin, William O C Cookson, Miriam Moffatt, Mark Lathrop, Valérie Siroux, Ludmila M Ogorodova, Alexandra S Karunas, Alan James, Nicole M Probst-Hensch, Erika von Mutius, Isabelle Pin, Manolis Kogevinas, A John Henderson, Florence Demenais, Emmanuelle Bouzigon
BACKGROUND: Asthma is a heterogeneous disease in which age of onset plays an important role. OBJECTIVE: We sought to identify the genetic variants associated with time to asthma onset (TAO). METHODS: We conducted a large-scale meta-analysis of 9 genome-wide association studies of TAO (total of 5462 asthmatic patients with a broad range of age of asthma onset and 8424 control subjects of European ancestry) performed by using survival analysis techniques...
October 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27120577/il-33-promotes-growth-and-liver-metastasis-of-colorectal-cancer-in-mice-by-remodeling-the-tumor-microenvironment-and-inducing-angiogenesis
#17
Yu Zhang, Celestia Davis, Sapana Shah, Daniel Hughes, James C Ryan, Diego Altomare, Maria Marjorette O Peña
Liver metastasis is the major cause of death from colorectal cancer (CRC). Understanding its mechanisms is necessary for timely diagnosis and development of effective therapies. Interleukin-33 (IL-33) is an IL-1 cytokine family member that uniquely functions as a cytokine and nuclear factor. It is released by necrotic epithelial cells and activated innate immune cells, functioning as an alarmin or an early danger signal. Its role in invoking type 2 immune response has been established; however, it has contrasting roles in tumor development and metastasis...
April 27, 2016: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/27097949/the-il33-st2-axis-in-sjogren-syndrome-in-relation-to-disease-activity
#18
D P E Margiotta, L Navarini, M Vadacca, M Lo Vullo, F Pignataro, F Basta, A Afeltra
OBJECTIVE: Primary Sjogren's Syndrome (pSS) is a systemic autoimmune disorder characterized by infiltration of the exocrine glands leading to secretory insufficiency. Despite the progress made in understanding the pathogenesis of the SS, many aspects remain to be clarified. Interleukin-33 (IL33) is a recently discovered cytokine, belonging to IL-1 superfamily. IL33 and its soluble receptor ST2 were implied in a number of immune and in autoimmune diseases pathogenesis. In this work ,we analyzed expression of IL33 and ST2 in Sjogren's syndrome...
April 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/27067050/upregulation-of-interleukin-33-in-obstructive-renal-injury
#19
Wei-Yu Chen, Ya-Jen Chang, Chia-Hao Su, Tzu-Hsien Tsai, Shang-Der Chen, Chung-Hsi Hsing, Jenq-Lin Yang
Interstitial fibrosis and loss of parenchymal tubular cells are the common outcomes of progressive renal diseases. Pro-inflammatory cytokines have been known contributing to the damage of tubular cells and fibrosis responses after renal injury. Interleukin (IL)-33 is a tissue-derived nucleus alarmin that drives inflammatory responses. The regulation and function of IL-33 in renal injury, however, is not well understood. To investigate the involvement of cytokines in the pathogenesis of renal injury and fibrosis, we performed the mouse renal injury model induced by unilateral urinary obstruction (UUO) and analyze the differentially upregulated genes between the obstructed and the contralateral unobstructed kidneys using RNA sequencing (RNAseq)...
May 13, 2016: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/27062360/t-cells-are-necessary-for-ilc2-activation-in-house-dust-mite-induced-allergic-airway-inflammation-in-mice
#20
Bobby W S Li, Marjolein J W de Bruijn, Irma Tindemans, Melanie Lukkes, Alex KleinJan, Henk C Hoogsteden, Rudi W Hendriks
Allergic asthma is a chronic inflammation of the airways mediated by an adaptive type 2 immune response. Upon allergen exposure, group 2 innate lymphoid cells (ILC2s) can be rapidly activated and represent an early innate source of IL-5 and IL-13. Here, we used a house dust mite (HDM)-driven asthma mouse model to study the induction of ILC2s in allergic airway inflammation. In BALF, lungs, and lymph nodes, ILC2 activation is critically dependent on prior sensitization with HDM. Importantly, T cells are required for ILC2 induction, whereby T-cell activation precedes ILC2 induction...
June 2016: European Journal of Immunology
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