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https://www.readbyqxmd.com/read/28430649/abcg2-and-ncf4-polymorphisms-are-associated-with-clinical-outcomes-in-diffuse-large-b-cell-lymphoma-patients-treated-with-r-chop
#1
Duo Liu, Nan Wu, Haiming Sun, Mei Dong, Tianzhu Guo, Peng Chi, Guofu Li, Donglin Sun, Yan Jin
The impact of pharmacogenetics on predicting survival in diffuse large B-cell lymphoma (DLBCL) remains unclear. We tested 337 DLBCL patients treated with rituximab-cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) for 9 single nucleotide polymorphisms from 6 genes (CD20, FCGR2A, NAD(P)H, ABCC2, ABCG2 and CYP3A5). Patients who carried the NCF4 rs1883112 GG genotype showed significantly shorter progression-free survival (PFS) (P = 0.023) and event-free survival (EFS) (P < 0.001) comparing with A allele...
April 6, 2017: Oncotarget
https://www.readbyqxmd.com/read/28429187/curcumin-reverses-the-depressive-like-behavior-and-insulin-resistance-induced-by-chronic-mild-stress
#2
Ji-Duo Shen, Yu Wei, Yu-Jie Li, Jing-Yi Qiao, Yu-Cheng Li
Increasing evidence has demonstrated that patients with depression have a higher risk of developing type 2 diabetes. Insulin resistance has been identified as the key mechanism linking depression and diabetes. The present study established a rat model of depression complicated by insulin resistance using a 12-week exposure to chronic mild stress (CMS) and investigated the therapeutic effects of curcumin. Sucrose intake tests were used to evaluate depressive-like behaviors, and oral glucose tolerance tests (OGTT) and intraperitoneal insulin tolerance tests (IPITT) were performed to evaluate insulin sensitivity...
April 21, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28422393/accuracy-and-response-time-of-dual-biomarker-model-of-insulin-like-growth-factor-binding-protein-1-alpha-fetoprotein-amnioquick-duo-in-comparison-to-placental-alpha-microglobulin-1-test-in-diagnosis-of-premature-rupture-of-membranes
#3
George Uchenna Eleje, Euzebus Chinonye Ezugwu, Ahizechukwu Chigoziem Eke, Joseph Ifeanyichukwu Ikechebelu, Chukwuemeka Okwudili Ezeama, Ifeanyichukwu Uzoma Ezebialu, Nnabuike Okechukwu Ojiegbe, Chukwudi Celestine Obiora, Charles Ikechukwu Okafor, Gerald Okanandu Udigwe, Betrand Obi Nwosu, Frank O Ezugwu
AIM: The aim of this study was to determine accuracy and response time of duo of insulin-like growth factor binding protein-1 (IGFBP-1)/alpha-fetoprotein (Amnioquick duo+) versus placental alpha-microglobulin-1 (PAMG-1) in diagnosing premature rupture of membranes (PROM). METHODS: A multicenter prospective study was conducted among women with features suggestive of PROM between 24 and 42 gestational weeks (GW). PROM was confirmed post-delivery based on presence of any two of these criteria: delivery within 48 h to 7 days, chorioamnionitis, membranes overtly ruptured at delivery, and adverse perinatal outcomes strongly correlated with prolonged PROM...
April 19, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/28397298/micromorphological-differences-of-the-implant-abutment-junction-and-in%C3%A2-vitro-load-testing-for-three-different-titanium-abutments-on-straumann-tissue-level-implants
#4
N Mattheos, C Larsson, L Ma, G Fokas, V Chronopoulos, M Janda
BACKGROUND: The aim of this study was to investigate the micromorphological differences among three commercially available titanium abutments on Straumann implants. Furthermore, the possible impact of functional loading on the micromorphology and potential complications was investigated with the use of in vitro testing. MATERIAL AND METHODS: Three groups of Titanium abutments (A: Straumann Variobase n = 5, B: EBI best Duo n = 5, and C: Implant Direct n = 5) were torqued on Straumann RN implants, as according to each of the manufacturer's instructions...
April 11, 2017: Clinical Oral Implants Research
https://www.readbyqxmd.com/read/28369081/rapid-diagnostic-tests-duo-as-alternative-to-conventional-serological-assays-for-conclusive-chagas-disease-diagnosis
#5
Karina E Egüez, Julio Alonso-Padilla, Carolina Terán, Zenobia Chipana, Wilson García, Faustino Torrico, Joaquim Gascon, Daniel-Franz Lozano-Beltran, María-Jesús Pinazo
Chagas disease is caused by the parasite Trypanosoma cruzi. It affects several million people, mainly in Latin America, and severe cardiac and/or digestive complications occur in ~30% of the chronically infected patients. Disease acute stage is mostly asymptomatic and infection goes undiagnosed. In the chronic phase direct parasite detection is hampered due to its concealed presence and diagnosis is achieved by serological methods, like ELISA or indirect hemagglutination assays. Agreement in at least two tests must be obtained due to parasite wide antigenic variability...
April 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28352309/asiaticoside-ameliorates-%C3%AE-amyloid-induced-learning-and-memory-deficits-in-rats-by-inhibiting-mitochondrial-apoptosis-and-reducing-inflammatory-factors
#6
Zhuo Zhang, Xiaobin Li, Duo Li, Mao Luo, Yongjie Li, Li Song, Xian Jiang
The present study aimed to investigate the effects of asiaticoside (AS) on the pathology and associated mechanisms of β-amyloid (Aβ)-induced Alzheimer's disease (AD) in rats. An AD rat model was established by lateral intracerebroventricular injection of Aβ 1-42 oligomers. Learning and memory function were evaluated by Morris water maze (MWM) test. In addition, hematoxylin and eosin (H&E) staining, transmission electron microscopy (TEM), immunohistochemistry, ELISA and western blot analysis were performed to evaluate the disease pathogenesis...
February 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28350456/starch-derived-nanographene-oxide-paves-the-way-for-electrospinnable-and-bioactive-starch-scaffolds-for-bone-tissue-engineering
#7
Duo Wu, Archana Samanta, Rajiv K Srivastava, Minna Hakkarainen
A straightforward process that enabled electrospinning of bioactive starch-based nanofiber scaffolds was developed by utilizing starch derived nano graphene oxide (nGO) as a property enhancer and formic acid as a solvent and esterification reagent. The reaction mechanism and process were followed by detailed spectroscopic investigation. Furthermore, the incorporation of nGO as a "green bioactive additive" endorsed starch nanofibrous scaffolds several advantageous functionalities including improved electrospinnability and thermal stability, good cytocompatibility, osteo-bioactivity, and retained biodegradability...
March 31, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28298727/using-computed-tomography-enterography-to-evaluate-patients-with-crohn-s-disease-what-impact-does-examiner-experience-have-on-the-reproducibility-of-the-method
#8
Stênio Burlin, Larissa Rossini Favaro, Elisa Almeida Sathler Bretas, Lincoln Seiji Taniguchi, Ana Paula Loch, Marjorie Costa Argollo, Orlando Ambrogini Junior, Giuseppe D'Ippolito
OBJECTIVE: To assess the impact that examiner experience has on the reproducibility and accuracy of computed tomography (CT) enterography in the detection of radiological signs in patients with Crohn's disease. MATERIALS AND METHODS: This was a retrospective, cross-sectional observational study involving the analysis of CT enterography scans of 20 patients with Crohn's disease. The exams were analyzed independently by two radiologists in their last year of residence (duo I) and by two abdominal imaging specialists (duo II)...
January 2017: Radiologia Brasileira
https://www.readbyqxmd.com/read/28296522/effect-of-spatial-separation-and-noise-type-on-sentence-recognition-by-mandarin-speaking-cochlear-implant-users
#9
Yang-Wenyi Liu, Duo-Duo Tao, Ye Jiang, John J GalvinIII, Qian-Jie Fu, Ya-Sheng Yuan, Bing Chen
OBJECTIVES: To investigate the effects of spatial separation and noise type on sentence recognition by unilateral Mandarin-speaking cochlear implant (CI) users and normal-hearing (NH) listeners. METHOD: Twenty-two unilateral Mandarin-speaking CI users and six NH listeners participated in this study. Speech reception thresholds were measured for three noise types (steady state noise, speech babble, and music). Sentences from the Mandarin Speech Perception test were presented directly in front of the listener (0°)...
March 15, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28278203/a-high-performance-seizure-detection-algorithm-based-on-discrete-wavelet-transform-dwt-and-eeg
#10
Duo Chen, Suiren Wan, Jing Xiang, Forrest Sheng Bao
In the past decade, Discrete Wavelet Transform (DWT), a powerful time-frequency tool, has been widely used in computer-aided signal analysis of epileptic electroencephalography (EEG), such as the detection of seizures. One of the important hurdles in the applications of DWT is the settings of DWT, which are chosen empirically or arbitrarily in previous works. The objective of this study aimed to develop a framework for automatically searching the optimal DWT settings to improve accuracy and to reduce computational cost of seizure detection...
2017: PloS One
https://www.readbyqxmd.com/read/28246934/forensic-characteristics-and-phylogenetic-analyses-of-the-chinese-yi-population-via-19-x-chromosomal-str-loci
#11
GuangLin He, Ye Li, Xing Zou, Ping Li, PengYu Chen, Feng Song, Tianzhen Gao, Miao Liao, Jing Yan, Jin Wu
The demographic characteristics and genetic polymorphism data of 56 Chinese nationalities or 31 administrative divisions in Chinese mainland have repeatedly been the genetic research hotspots. While most genetic studies focused on some particular Chinese populations based on autosomal or Y-chromosomal genetic markers, the forensic characteristics and phylogenetic analyses of the seventh largest Chinese population (Yi ethnicity) on the X-chromosomal genetic markers are scarce. Here, allele frequencies and forensic statistical parameters for 19 X-chromosomal short tandem repeat loci (DXS7424-DXS101, DXS6789-DXS6809, DXS7423-DXS10134, DXS10103-HPRTB-DXS10101, DXS10159-DXS10162-DXS10164, DXS10148-DXS10135-DXS8378, and DXS7132-DXS10079-DXS10074-DXS10075) of 331 Chinese Yi individuals were obtained...
February 28, 2017: International Journal of Legal Medicine
https://www.readbyqxmd.com/read/28213267/ferulic-acid-inhibits-neuro-inflammation-in-mice-exposed-to-chronic-unpredictable-mild-stress
#12
Ya-Min Liu, Ji-Duo Shen, Li-Ping Xu, Han-Bing Li, Yu-Cheng Li, Li-Tao Yi
Ferulic acid is a hydroxycinnamic acid that widely presents in plant cell wall components. It has been demonstrated that ferulic acid can attenuate depressive-like behaviors in both forced swimming test and tail suspension test. Considering that depression is an inflammatory related mental disease, our present study was aimed to investigate the role of ferulic acid in the regulation of microglia activation, pro-inflammatory cytokines, nuclear factor kappa B (NF-κB) and nucleotide binding and oligomerization domain-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome in mice exposed to chronic unpredictable mild stress (CUMS)...
February 14, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28202270/acute-metabolic-and-endocrine-responses-induced-by-glucose-and-fructose-in-healthy-young-subjects-a-double-blinded-randomized-crossover-trial
#13
Wenwen Cai, Jie Li, Jiahui Shi, Bo Yang, Jun Tang, Helen Truby, Duo Li
BACKGROUND AND OBJECTIVE: A rise in fructose consumption has been implicated in the etiology of obesity, diabetes and cardiovascular disease. Serum uric acid (UA) elevates after fructose ingestion, increasing the risk of cardiovascular disease. However, the impact of fructose ingestion on nitric oxide (NO) has not yet been confirmed. The aim of this study was to investigate the postprandial metabolic and endocrine responses following an acute ingestion of fructose and glucose in healthy subjects...
February 3, 2017: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28155677/finite-element-analysis-of-the-valgus-knee-joint-of-an-obese-child
#14
Jun Sun, Songhua Yan, Yan Jiang, Duo Wai-Chi Wong, Ming Zhang, Jizhou Zeng, Kuan Zhang
BACKGROUND: Knee valgus and varus morbidity is at the second top place in children lower limb deformity diseases. It may cause abnormal stress distribution. The magnitude and location of contact forces on tibia plateau during gait cycle have been indicated as markers for risk of osteoarthritis. So far, few studies reported the contact stress and force distribution on tibial plateau of valgus knee of children. METHODS: To estimate the contact stresses and forces on tibial plateau of an 8-year old obese boy with valgus knee and a 7-year old healthy boy, three-dimensional (3D) finite element (FE) models of their left knee joints were developed...
December 28, 2016: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28149471/bond-strength-of-adhesive-resin-cement-with-different-adhesive-systems
#15
Fabrizio Lorenzoni E Silva, Saulo Pamato, Milton-Carlos Kuga, Marcus-Vinicius-Reis Só, Jefferson-Ricardo Pereira
BACKGROUND: To assess the immediate bond strength of a dual-cure adhesive resin cement to the hybridized dentin with different bonding systems. MATERIAL AND METHODS: Fifty-six healthy human molars were randomly divided into 7 groups (n=8). After 3 longitudinal sections, the central cuts were included in PVC matrix and were submitted to dentin hybridization according to the groups: G1 - etch & rinse system with 3-step (Apder™ Scotchbond™ Multi-Purpose, 3M ESPE), G2 - etch & rinse system with 3-step (Optibond™ FL, Kerr), G3 - etch & rinse system with 3-step (All-Bond 3®, Bisco), G4 - etch & rinse simplified system (Adper™ Single Bond 2, 3M ESPE), G5 - self-etching system with one step (Bond Force, Tokuyama), G6 - universal system in moist dentin (Single Bond Universal, 3M ESPE), G7 - universal system in dry dentin (Single Bond Universal, 3M ESPE)...
January 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28129346/temperature-of-a-dengue-rapid-diagnostic-test-under-tropical-climatic-conditions-a-follow-up-study
#16
Onanong Sengvilaipaseuth, Koukeo Phommasone, Xavier de Lamballerie, Manivanh Vongsouvath, Ooyanong Phonemixay, Stuart D Blacksell, Mayfong Mayxay, Sommay Keomany, Phoutthalavanh Souvannasing, Paul N Newton, Audrey Dubot-Pérès
The Dengue Duo Rapid Diagnostic Test (SD Dengue RDT) has good specificity and sensitivity for dengue diagnosis in rural tropical areas. In a previous study, using four control sera, we demonstrated that that the diagnostic accuracy of these RDTs remains stable after long-term storage at high temperatures. We extended this study by testing sera from 119 febrile patients collected between July-November 2012 at Salavan Provincial Hospital (southern Laos) with RDTs stored for 6 months at 4°C, 35° and in a hut (miniature traditional house) at Lao ambient temperatures...
2017: PloS One
https://www.readbyqxmd.com/read/28111135/fracture-resistance-of-glazed-full-contour-zls-incisor-crowns
#17
Franz Sebastian Schwindling, Stefan Rues, Marc Schmitter
PURPOSE: To compare the failure behaviour of zirconia-reinforced lithium silicate (Celtra Duo, DeguDent) with that of lithium disilicate (IPS e.max CAD, Ivoclar Vivadent) and feldspar (Mark II, VITA) ceramics. METHODS: Three groups of sixteen glazed maxillary incisor crowns were produced. The inner surfaces of the crowns were etched, then luted to metal dies with self-adhesive cement. Single load-to-failure tests were performed before and after thermo-mechanical ageing...
January 19, 2017: Journal of Prosthodontic Research
https://www.readbyqxmd.com/read/28067277/spatio-temporal-patterns-of-proportions-of-influenza-b-cases
#18
Daihai He, Alice P Y Chiu, Qianying Lin, Duo Yu
We studied the spatio-temporal patterns of the proportions of influenza B cases out of all typed cases, with data from 139 countries and regions downloaded from the FluNet compiled by the World Health Organization, from January 2006 to October 2015. We restricted our analysis to 34 countries that reported more than 2,000 confirmations for each of types A and B over the study period. Globally, we found that Pearson's correlation is greater than 0.6 between effective distance from Mexico and the proportions of influenza B cases among the countries during the post-pandemic era (i...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/27998852/-isolation-identification-and-lead-adsorption-study-of-lead-resistant-lactobacillus-casei-strains-from-feces-of-healthy-newborns
#19
Wei Shen, Qin-Fei Yu, Yu-Hao Wang, Yi-Duo Zhang, Xiao-Jing Meng, Hong-Ying Fan
OBJECTIVE: To isolate and identify lead-resistant Lactobacillus casei strains with lead adsorption ability from the stool of healthy newborns as a new source of bacteria for developing lead-eliminating food products. METHODS: MRS was used to isolate lead-resistant bacteria from the feces of 30 healthy and full-term neonates. A phylogenetic tree was constructed based on the morphological characteristics and 16S rRNA sequences of the isolated bacteria. Physiological and biochemical characterizations of the bacteria were performed according to the Berger's Systematic Bacteriology Handbook, followed by antimicrobial susceptibility test and acid-tolerant bile salt test...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27969267/double-loop-ureteral-stents-encrustation-according-to-indwelling-time-results-of-a-european-multicentric-study
#20
T Saussez, A Ruffion, A Celia, F Djouhri, G Musi, I Desriac, T Roumeguere
OBJECTIFS: Double J ureteral stents (DJ), whatever their material, are rapidly covered by a biofilm, subject to encrustation onset. To prevent this, it is admitted that DJ should be replaced periodically. However, encrustation may vary with indication, with a highest risk in "stone" patients. Our target was to evaluate the actual DJ medium/long-term indwelling times and relevant encrustation rates perceived by urologists in daily practice. MéTHODES: Data were collected through an observational retrospective study...
November 2016: Progrès en Urologie
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