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https://www.readbyqxmd.com/read/27906009/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#1
REVIEW
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
September 26, 2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27884403/chairside-cad-cam-materials-part-2-flexural-strength-testing
#2
Michael Wendler, Renan Belli, Anselm Petschelt, Daniel Mevec, Walter Harrer, Tanja Lube, Robert Danzer, Ulrich Lohbauer
OBJECTIVE: Strength is one of the preferred parameters used in dentistry for determining clinical indication of dental restoratives. However, small dimensions of CAD/CAM blocks limit reliable measurements with standardized uniaxial bending tests. The objective of this study was to introduce the ball-on-three-ball (B3B) biaxial strength test for dental for small CAD/CAM block in the context of the size effect on strength predicted by the Weibull theory. METHODS: Eight representative chairside CAD/CAM materials ranging from polycrystalline zirconia (e...
November 21, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
https://www.readbyqxmd.com/read/27879623/dynamic-duos-jamaican-fruit-bats-artibeus-jamaicensis-do-not-show-prosocial-behavior-in-a-release-paradigm
#3
Eric Hoffmaster, Jennifer Vonk
Once thought to be uniquely human, prosocial behavior has been observed in a number of species, including vampire bats that engage in costly food-sharing. Another social chiropteran, Jamaican fruit bats (Artibeus jamaicensis), have been observed to engage in cooperative mate guarding, and thus might be expected to display prosocial behavior as well. However, frugivory and hematophagy diets may impose different selection pressures on prosocial preferences, given that prosocial preferences may depend upon cognitive abilities selected by different ecological constraints...
November 20, 2016: Behavioral Sciences
https://www.readbyqxmd.com/read/27866268/a-genome-wide-association-study-of-essential-hypertension-in-an-australian-population-using-a-dna-pooling-approach
#4
Javed Y Fowdar, Rebecca Grealy, Yi Lu, Lyn R Griffiths
Despite the success of genome-wide association studies (GWAS) in detecting genetic loci involved in complex traits, few susceptibility genes have been detected for essential hypertension (EH). We aimed to use pooled DNA GWAS approach to identify and validate novel genomic loci underlying EH susceptibility in an Australian case-control population. Blood samples and questionnaires detailing medical history, blood pressure, and prescribed medications were collected for 409 hypertensives and 409 age-, sex- and ethnicity-matched normotensive controls...
November 19, 2016: Molecular Genetics and Genomics: MGG
https://www.readbyqxmd.com/read/27834558/comprehensive-gait-analysis-of-healthy-older-adults-who-have-undergone-long-distance-walking
#5
Mustafa M O Elhadi, Christina Z Ma, Duo W C Wong, Anson H P Wan, Winson C C Lee
Many older adults do not adhere to the recommended physical activity levels. This study examines the gait changes upon long-distance walking among healthy older adults. Gait tests of 24 adults aged 65 or more were conducted at the baseline, at the end of 30 and 60 minutes of treadmill walk. Spatial temporal, kinematic and kinetic gait data were computed. Perceived level of exertion was evaluated for each subject. Ten subjects (Group B) perceived higher exertion level than the remaining fourteen subjects (Group A)...
November 11, 2016: Journal of Aging and Physical Activity
https://www.readbyqxmd.com/read/27830170/behavior-data-of-battery-and-battery-pack-soc-estimation-under-different-working-conditions
#6
Xu Zhang, Yujie Wang, Duo Yang, Zonghai Chen
This article provides the dataset of operating conditions of battery behavior. The constant current condition and the dynamic stress test (DST) condition were carried out to analyze the battery discharging and charging features. The datasets were achieved at room temperature, in April, 2016. The shared data contributes to clarify the battery pack state-of-charge (SOC) and the battery inconsistency, which is also shown in the article of "An on-line estimation of battery pack parameters and state-of-charge using dual filters based on pack model" (X...
December 2016: Data in Brief
https://www.readbyqxmd.com/read/27822610/polymorphisms-in-cytokine-genes-as-prognostic-markers-in-diffuse-large-b-cell-lymphoma-patients-treated-with-r-chop
#7
Duo Liu, Yuhui Wang, Mei Dong, Shangwei Guan, Yan Wang, Haiming Sun, Nan Wu, Su Li, Jing Bai, Feng Chen, Donglin Sun, Yan Jin
To investigate whether cytokine genetic polymorphisms influence the outcome of diffuse large B cell lymphoma (DLBCL), we tested 337 consecutive DLBCL treated with CHOP or rituximab-CHOP (R-CHOP) from interleukin 10 (IL10), Bcl-2, and tumor necrosis factor (TNF)-α polymorphisms. Patients who carried the IL10 rs1800871 TT or rs1800872 AA genotype showed higher complete response (CR) and overall response rate (ORR) significantly. A longer progression-free survival (PFS) was observed in patients with IL10 rs1800871 TT (P = 0...
November 7, 2016: Annals of Hematology
https://www.readbyqxmd.com/read/27806758/-biological-evaluation-of-three-dimensional-printed-co-poly-lactic-acid-glycolic-acid-tri-calcium-phosphate-scaffold-for-bone-reconstruction
#8
S Y Li, M Zhou, Y X Lai, Y M Geng, S S Cao, X M Chen
Objective: To biologically evaluate the three-dimensional(3D) printed co-poly lactic acid/glycolic acid/tri-calcium phosphate(PLGA/TCP) scaffold which could be used for repairing oral and maxillofacial bone defects, and to provide experimental evidence for its further research and clinical application. Methods: PLGA/TCP scaffolds were fabricated using low temperature rapid prototyping technique. Micro-CT and scanning electron microscope(SEM) were used to characterize the surface morphology. MC3T3-E1 cells were seeded onto the scaffold and stained with the rhodamine phalloidin and calcein acetomethoxy...
November 9, 2016: Zhonghua Kou Qiang Yi Xue za Zhi, Zhonghua Kouqiang Yixue Zazhi, Chinese Journal of Stomatology
https://www.readbyqxmd.com/read/27796911/accelerating-regulated-bioanalysis-for-biotherapeutics-case-examples-using-a-microfluidic-ligand-binding-assay-platform
#9
Rong Liu, Brian Hoffpauir, Shannon D Chilewski, Janice Gamberdella, Uma Kavita, Jia Duo, Carol Gleason, Yan Zhang, Renuka Pillutla, Binodh DeSilva, Lora Hamuro
The Gyrolab™ xP is a microfluidic platform for conducting ligand binding assays (LBAs) and is recognized for its utility in discovery bioanalysis. However, few reports have focused on the technology for regulated bioanalysis. This technology has the advantage of low reagent consumption, low sample volume, and automated ligand binding methods. To improve bioanalysis testing timelines and increase the speed at which biotherapeutics are delivered to patients, we evaluated the technology for its potential to deliver high-quality data at reduced testing timelines for regulated bioanalysis...
October 27, 2016: AAPS Journal
https://www.readbyqxmd.com/read/27782723/automatic-multiorgan-segmentation-in-ct-images-of-the-male-pelvis-using-region-specific-hierarchical-appearance-cluster-models
#10
Dengwang Li, Pengxiao Zang, Xiangfei Chai, Yi Cui, Ruijiang Li, Lei Xing
PURPOSE: Accurate segmentation of pelvic organs in CT images is of great importance in external beam radiotherapy for prostate cancer. The aim of this studying is to develop a novel method for automatic, multiorgan segmentation of the male pelvis. METHODS: The authors' segmentation method consists of several stages. First, a pretreatment includes parameterization, principal component analysis (PCA), and an established process of region-specific hierarchical appearance cluster (RSHAC) model which was executed on the training dataset...
October 2016: Medical Physics
https://www.readbyqxmd.com/read/27764220/epidemiology-and-clinical-presentations-of-respiratory-syncytial-virus-subgroups-a-and-b-detected-with-multiplex-real-time-pcr
#11
Wenkuan Liu, Dehui Chen, Weiping Tan, Duo Xu, Shuyan Qiu, Zhiqi Zeng, Xiao Li, Rong Zhou
Respiratory syncytial virus (RSV) is one of the most important pathogenic infections of children and requires in-depth research worldwide, and especially in developing countries. We used a novel multiplex real-time PCR to test 5483 patients (≤ 14 years old) hospitalized with respiratory illness in Guangzhou, China, over a 3-year period. Of these patients, 729 were positive for RSV-A (51.2%, 373/729) or RSV-B (48.8%, 356/729), but none was infected with both viruses. Two seasonal peaks in total RSV were detected at the changes from winter to spring and from summer to autumn...
2016: PloS One
https://www.readbyqxmd.com/read/27754387/resveratrol-ameliorates-the-depressive-like-behaviors-and-metabolic-abnormalities-induced-by-chronic-corticosterone-injection
#12
Yu-Cheng Li, Ya-Min Liu, Ji-Duo Shen, Jun-Jie Chen, Yang-Yi Pei, Xiao-Yan Fang
Chronic glucocorticoid exposure is known to cause depression and metabolic disorders. It is critical to improve abnormal metabolic status as well as depressive-like behaviors in patients with long-term glucocorticoid therapy. This study aimed to investigate the effects of resveratrol on the depressive-like behaviors and metabolic abnormalities induced by chronic corticosterone injection. Male ICR mice were administrated corticosterone (40 mg/kg) by subcutaneous injection for three weeks. Resveratrol (50 and 100 mg/kg), fluoxetine (20 mg/kg) and pioglitazone (10 mg/kg) were given by oral gavage 30 min prior to corticosterone administration...
October 13, 2016: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/27751829/the-orbicularis-oculi-muscle-resection-technique-for-medial-epicanthoplasty-a-retrospective-review-of-surgical-outcomes-in-47-chinese-patients
#13
Hai-Peng Liu, Yan-Ying Zhao, Bing Li, Jun Qi, Duo Zhang
BACKGROUND: Epicanthal folds and single eyelids are considered characteristic East Asian traits. This study describes a new approach to medial epicanthoplasty based on an orbicularis oculi muscle resection technique and reports the surgical outcomes in Chinese patients. METHODS: The study presents an uncontrolled retrospective case series review of 47 Chinese patients who underwent medial epicanthoplasty with double eyelid surgery from December 2010 to December 2014 by traditional medial epicanthoplasty (Group I, n = 23) or medial epicanthoplasty using the orbicularis oculi muscle resection technique (Group II, n = 24)...
September 20, 2016: Journal of Plastic, Reconstructive & Aesthetic Surgery: JPRAS
https://www.readbyqxmd.com/read/27708678/current-trends-and-intricacies-in-the-management-of-hiv-associated-pulmonary-tuberculosis
#14
Narendran Gopalan, Padmapriyadarsini Chandrasekaran, Soumya Swaminathan, Srikanth Tripathy
Human immunodeficiency virus (HIV) epidemic has undoubtedly increased the incidence of tuberculosis (TB) globally, posing a formidable global health challenge affecting 1.2 million cases. Pulmonary TB assumes utmost significance in the programmatic perspective as it is readily transmissible as well as easily diagnosable. HIV complicates every aspect of pulmonary tuberculosis from diagnosis to treatment, demanding a different approach to effectively tackle both the diseases. In order to control these converging epidemics, it is important to diagnose early, initiate appropriate therapy for both infections, prevent transmission and administer preventive therapy...
2016: AIDS Research and Therapy
https://www.readbyqxmd.com/read/27699021/a-model-for-predicting-nosocomial-carbapenem-resistant-klebsiella-pneumoniae-infection
#15
Duo Yang, Zeqiang Xie, Xuli Xin, Wenying Xue, Man Zhang
Mortality associated with infections due to carbapenem-resistant Klebsiella pneumoniae (CR-KP) is high and the infections need to be predicted early. The risk factors for CR-KP infection are heterogeneous. The aim of the present study was to construct a model allowing for the early prediction of CR-KP infection. Nosocomial infections due to K. pneumoniae were evaluated retrospectively over a 2-year period. The case cohort consisted of 370 inpatients with CR-KP infection. For each case enrolled, two matched controls with no CR-KP infection during their hospitalization were randomly selected...
October 2016: Biomedical Reports
https://www.readbyqxmd.com/read/27695091/ceramic-case-control-association-testing-in-samples-with-related-individuals-based-on-retrospective-mixed-model-analysis-with-adjustment-for-covariates
#16
Sheng Zhong, Duo Jiang, Mary Sara McPeek
We consider the problem of genetic association testing of a binary trait in a sample that contains related individuals, where we adjust for relevant covariates and allow for missing data. We propose CERAMIC, an estimating equation approach that can be viewed as a hybrid of logistic regression and linear mixed-effects model (LMM) approaches. CERAMIC extends the recently proposed CARAT method to allow samples with related individuals and to incorporate partially missing data. In simulations, we show that CERAMIC outperforms existing LMM and generalized LMM approaches, maintaining high power and correct type 1 error across a wider range of scenarios...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27689836/blue-light-transmittance-of-esthetic-monolithic-cad-cam-materials-with-respect-to-their-composition-thickness-and-curing-conditions
#17
B Stawarczyk, D Awad, N Ilie
Determining the amount of blue light (360-540nm) passing through nine monolithic computer-aided design/computer-aided manufacturing (CAD/CAM) materials depends on material thickness, initial irradiance, and the distance between the curing unit and the specimen's surface. A total of 180 specimens of two thicknesses (1 mm and 2 mm, n=10/subgroup) were fabricated from TelioCAD, VITA CAD-Temp (VCT), experimental nanocomposite, LAVA Ultimate (LU), VITA ENAMIC (VE), VITA MarkII (VM), IPS EmpressCAD (IEC), IPS e.maxCAD (IEM), and CELTRA DUO (CD)...
September 2016: Operative Dentistry
https://www.readbyqxmd.com/read/27673680/the-prevalence-of-vitiligo-a-meta-analysis
#18
Yuhui Zhang, Yunfei Cai, Meihui Shi, Shibin Jiang, Shaoshan Cui, Yan Wu, Xing-Hua Gao, Hong-Duo Chen
OBJECTIVE: To conduct a meta-analysis assessing the prevalence of vitiligo. METHODS: Literatures that reported prevalence rates of vitiligo were identified using EMBASE, PubMed, the Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang database and Weipu database for the period from inception to May 2016. We performed stratified analyses on possible sources of bias, including areas difference, years of publication, gender and age. Publication bias was assessed with Egger's test method...
2016: PloS One
https://www.readbyqxmd.com/read/27670224/genetic-variability-and-forensic-efficiency-of-39-microsatellite-loci-in-the-li-ethnic-group-from-hainan-island-in-south-china-sea
#19
Jing Chen, Bingbing Xie, Yaran Yang, Meng Yang, Chao Liu, Yuexin Lv, Chuguang Chen, Xiu Liu, Xiangdong Fang, Huijuan Wu, Jiangwei Yan
BACKGROUND: Investigation of allele and genotype frequencies of microsatellite loci in various populations is an essential prerequisite in forensic application. AIM: In the present study, we obtained population genetic data and forensic parameters of 39 autosomal Short Tandem Repeats (STRs) loci from Chinese Li ethnic group and estimated the genetic relationships between Li and other reference populations. SUBJECTS AND METHODS: Thirty-nine STR loci, which include D19S433, D5S818, D21S11, D18S51, D6S1043, D3S1358, D13S317, D7S820, D16S539, CSF1PO, Penta D, D2S441, vWA, D8S1179, TPOX, Penta E, TH01, D12S391, D2S1338, FGA, D6S477, D18S535, D19S253, D15S659, D11S2368, D20S470, D1S1656, D22-GATA198B05, D8S1132, D4S2366, D21S1270, D13S325, D9S925, D3S3045, D14S608, D10S1435, D7S3048, D17S1290 and D5S2500, were amplified two multiplex DNA-STR fluorescence detection systems for 189 unrelated healthy individuals of Chinese Li ethnic group...
September 26, 2016: Annals of Human Biology
https://www.readbyqxmd.com/read/27639808/wear-strength-modulus-and-hardness-of-cad-cam-restorative-materials
#20
Nathaniel C Lawson, Ritika Bansal, John O Burgess
OBJECTIVE: To measure the mechanical properties of several CAD/CAM materials, including lithium disilicate (e.max CAD), lithium silicate/zirconia (Celtra Duo), 3 resin composites (Cerasmart, Lava Ultimate, Paradigm MZ100), and a polymer infiltrated ceramic (Enamic). METHODS: CAD/CAM blocks were sectioned into 2.5mm×2.5mm×16mm bars for flexural strength and elastic modulus testing and 4mm thick blocks for hardness and wear testing. E.max CAD and half the Celtra Duo specimens were treated in a furnace...
September 14, 2016: Dental Materials: Official Publication of the Academy of Dental Materials
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