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Competitive endogenous RNA

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https://www.readbyqxmd.com/read/29147064/lncrna-neat1-regulates-cell-viability-and-invasion-in-esophageal-squamous-cell-carcinoma-through-the-mir-129-ctbp2-axis
#1
Yong Li, Dong Chen, Xiang Gao, Xiaohui Li, Gongning Shi
Background: Long noncoding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be aberrantly upregulated and promote esophageal squamous cell carcinoma (ESCC) cell progression. Nevertheless, the molecular mechanism of NEAT1 involved in the competing endogenous RNA (ceRNA) regulatory network in ESCC progression remains poorly defined. Methods: The expressions of NEAT1, miR-129, and C-terminal-binding protein 2 (CTBP2) in ESCC cells were examined by qRT-PCR...
2017: Disease Markers
https://www.readbyqxmd.com/read/29146309/stard13-3-untranslated-region-functions-as-a-cerna-for-tp53inp1-in-prohibiting-migration-and-invasion-of-breast-cancer-cells-by-regulating-mir-125b-activity
#2
Lufeng Zheng, Xiaoman Li, Jinjiang Chou, Chenxi Xiang, Qianqian Guo, Zhiting Zhang, Xinwei Guo, Lanlan Gao, Yingying Xing, Tao Xi
Competitive endogenous messenger RNA (ceRNA) affects transcription of other RNA molecules by competitively binding common microRNAs. Previous studies have shown that TP53INP1 functions as a suppressor in tumor metastasis. Our study elucidated StarD13 messenger RNA as a ceRNA in regulating migration and invasion of breast cancer cells. MicroRNA-125b was identified to induce metastasis of MCF-7 cells and bind with both StarD13 3'UTR and TP53INP1 3'UTR. Therefore, a ceRNA interaction between StarD13 and TP53INP1 mediated by competitively binding to miR-125b was indicated...
November 11, 2017: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29131440/mir-193b-availability-is-antagonized-by-lncrna-snhg7-for-faim2-induced-tumour-progression-in-non-small-cell-lung-cancer
#3
Kelin She, Hui Yan, Jun Huang, Huaping Zhou, Jianxing He
OBJECTIVES: Long non-coding RNAs have identified to involve into the tumour cell proliferation, apoptosis and metastasis. We previously found that up-regulated LncRNA-SNHG7 (SNHG7) positively correlated to the Fas apoptosis inhibitory molecule 2 (FAIM2) in lung cancer cells with unclear mechanism. METHODS: Non-small cell lung cancer (NSCLC) and relative normal tissues (n = 25) were collected. The SNHG7 expression and function in NSCLC was determined. The SNHG7-miR 193b-FAIM2 network was analysed in vitro and vivo...
November 12, 2017: Cell Proliferation
https://www.readbyqxmd.com/read/29121972/long-noncoding-rna-norad-a-novel-competing-endogenous-rna-enhances-the-hypoxia-induced-epithelial-mesenchymal-transition-to-promote-metastasis-in-pancreatic-cancer
#4
Hongzhe Li, Xinjing Wang, Chenlei Wen, Zhen Huo, Weishen Wang, Qian Zhan, Dongfeng Cheng, Hao Chen, Xiaxing Deng, Chenghong Peng, Baiyong Shen
BACKGROUND: Pancreatic cancer, one of the top two most fatal cancers, is characterized by a desmoplastic reaction that creates a dense microenvironment, promoting hypoxia and inducing the epithelial-to-mesenchymal transition (EMT) to facilitate invasion and metastasis. Recent evidence indicates that the long noncoding RNA NORAD may be a potential oncogenic gene and that this lncRNA is significantly upregulated during hypoxia. However, the overall biological role and clinical significance of NORAD remains largely unknown...
November 9, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29115513/lncrna-pvt1-regulate-expression-of-hif1%C3%AE-via-functioning-as-cerna-for-mir%C3%A2-199a%C3%A2-5p-in-non%C3%A2-small-cell-lung-cancer-under-hypoxia
#5
Chunhong Wang, Chunfang Han, Yibo Zhang, Fengqin Liu
Non‑small cell lung cancer (NSCLC) represents one of the most important causes of cancer mortality in the world, and leads to the largest number of deaths in all kinds of lung cancer. Hypoxia has been confirmed to be a characteristic feature of NSCLC and has been shown to decrease the therapeutic efficacy of radiotherapy and some forms of chemotherapy. Previous studies revealed that many miRNAs have been proven to be involved in the molecular regulation of hypoxia and to affect the protein expression level of HIF‑1α...
November 3, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29106390/glycolysis-gatekeeper-pdk1-reprograms-breast-cancer-stem-cells-under-hypoxia
#6
F Peng, J-H Wang, W-J Fan, Y-T Meng, M-M Li, T-T Li, B Cui, H-F Wang, Y Zhao, F An, T Guo, X-F Liu, L Zhang, L Lv, D-K Lv, L-Z Xu, J-J Xie, W-X Lin, E W-F Lam, J Xu, Q Liu
Glycolysis is critical for cancer stem cell reprogramming; however, the underlying regulatory mechanisms remain elusive. Here, we show that pyruvate dehydrogenase kinase 1 (PDK1) is enriched in breast cancer stem cells (BCSCs), whereas depletion of PDK1 remarkably diminishes ALDH(+) subpopulations, decreases stemness-related transcriptional factor expression, and inhibits sphere-formation ability and tumor growth. Conversely, high levels of PDK1 enhance BCSC properties and are correlated with poor overall survival...
November 6, 2017: Oncogene
https://www.readbyqxmd.com/read/29100288/long-noncoding-rna-xist-promotes-malignancies-of-esophageal-squamous-cell-carcinoma-via-regulation-of-mir-101-ezh2
#7
Xiaoliang Wu, Xiaoxiao Dinglin, Xing Wang, Wen Luo, Qi Shen, Yong Li, Ling Gu, Qianghua Zhou, Haotu Zhu, Yanjie Li, Chaodi Tan, Xianzi Yang, Zhenfeng Zhang
The long non-coding RNA XIST is a long non-coding RNA that associates with polycomb repressive complex 2 to regulate X-chromosome inactivation in female mammals. The biological roles as well as the underlying mechanisms of XIST in esophageal squamous cell carcinoma remained yet to be solved. Our data indicated that XIST was significantly upregulated in esophageal squamous cancerous tissues and cancer cell lines, as compared with that in the corresponding non-cancerous tissues and immortalized normal squamous epithelial cells...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29070041/lncrna-rp11-436h11-5-functioning-as-a-competitive-endogenous-rna-upregulates-bcl-w-expression-by-sponging-mir-335-5p-and-promotes-proliferation-and-invasion-in-renal-cell-carcinoma
#8
Kefeng Wang, Wei Jin, Yan Song, Xiang Fei
BACKGROUND: Accumulating evidence indicates that long non-coding RNAs (lncRNAs) play a crucial role in tumorigenesis. Here, we report a novel lncRNA, RP11-436H11.5, that regulates renal cell carcinoma (RCC) cell proliferation and invasion by sponging miR-335-5p. METHODS: Expression of lncRNA RP11-436H11.5 was determined by a qRT-PCR assay in RCC tissues. RCC cell proliferation and invasion were measured by a cell proliferation assay and a transwell invasion assay...
October 25, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29048648/long-non-coding-rna-xist-regulates-pdcd4-expression-by-interacting-with-mir-21-5p-and-inhibits-osteosarcoma-cell-growth-and-metastasis
#9
Rui Zhang, Tian Xia
lncRNA-X-inactive specific transcript (lncRNA XIST) has been demonstrated to be a tumor suppressor involved in the pathogenesis and development of various cancers. However, the function of XIST and its working mechanism in osteosarcoma (OS) remain enigmatic. Firstly, we determined the expression of XIST in OS tissues and cell lines by quantitative reverse transcription-PCR (qRT-PCR) and explored whether aberrant XIST expression was associated with recurrence and short overall survival. Furthermore, the effects of XIST on osteosarcoma cells were studied by lentivirus mediated overexpression approach in vitro and in vivo...
September 19, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28984028/linc00511-acts-as-a-competing-endogenous-rna-to-regulate-vegfa-expression-through-sponging-hsa-mir-29b-3p-in-pancreatic-ductal-adenocarcinoma
#10
Xiaohui Zhao, Yimin Liu, Zhihua Li, Shangyou Zheng, Zairui Wang, Wenzhu Li, Zhuofei Bi, Liting Li, Yanhui Jiang, Yuming Luo, Qing Lin, Zhiqiang Fu, Chen Rufu
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy. Long non-coding RNAs (lncRNAs) are important regulators in pathological processes, yet their potential roles in PDAC are poorly understood. Here, we identify a fundamental role for a novel lincRNA, linc00511, in the progression of PDAC. Linc00511 levels in PDAC tissue specimens and cell lines were examined by quantitative real-time PCR. Corresponding adjacent non-neoplastic tissues were used as controls. The function of linc00511 in PDAC cell lines was determined by RNA interference approach in vitro and in vivo...
October 5, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28977880/knockdown-of-malat1-expression-inhibits-huvec-proliferation-by-upregulation-of-mir-320a-and-downregulation-of-foxm1-expression
#11
Jian-Yong Sun, Zheng-Wei Zhao, Wei-Miao Li, Guang Yang, Peng-Yu Jing, Pei Li, Hai-Zhou Dang, Zhao Chen, Yong-An Zhou, Xiao-Fei Li
Regulation of cancer angiogenesis could be a useful strategy in cancer therapy. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is a long non-coding RNA (lncRNA), and can induce cancer cell proliferation, while lncRNAs, generally are able to act as microRNA (miRNA) sponges. The latter is a type of competitive endogenous RNA (ceRNA) that regulates expression of the targeting miRNAs and protein-coding genes. This study investigated the proliferative role of MALAT1 in human umbilical vein endothelial cells (HUVECs) and the underlying molecular events...
September 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938647/long-non-coding-rna-malat1-for-promoting-metastasis-and-proliferation-by-acting-as-a-cerna-of-mir-144-3p-in-osteosarcoma-cells
#12
Yong Wang, Yueyang Zhang, Tao Yang, Wei Zhao, Ningning Wang, Pengcheng Li, Xiandong Zeng, Weiguo Zhang
Long non-coding RNAs (lncRNAs) are involved in various biological processes and diseases including osteosarcoma. Long non-coding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is overly expressed in osteosarcoma. But the function and mechanism it works on in osteosarcoma proliferation and metastasis mediated by Rho associated coiled-coil containing protein kinase 1 (ROCK1) and Rho associated coiled-coil containing protein kinase 2 (ROCK2) remain unclear. In the present study, an elevated MALAT1 was found in osteosarcoma tissues and cell lines, and the elevated MALAT1 was correlated with a poor prognosis in osteosarcoma patients...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28938616/identification-of-potential-cancer-related-pseudogenes-in-lung-adenocarcinoma-based-on-cerna-hypothesis
#13
Yunzhen Wei, Zhiqiang Chang, Cheng Wu, Yinling Zhu, Kun Li, Yan Xu
Pseudogenes are initially regarded as non-functional genomic fossils resulted from inactivating gene mutations during evolution. Far from being silent, pseudogenes are proved to regulate the expression of protein-coding genes through function as microRNA sponge in vivo. The aim of our study was to propose an integrative systems biology approach to identify disease pseudogenes base on competitive endogenous RNA (ceRNA) hypothesis. Here, we applied our method to lung adenocarcinoma (LUAD) RNASeq data from TCGA and identified 33 candidate pseudogenes...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28915561/differentially-expressed-lncrnas-and-mirnas-with-associated-cerna-networks-in-aged-mice-with-postoperative-cognitive-dysfunction
#14
Changwei Wei, Ting Luo, Shanshan Zou, Xiaobin Zhou, Wenzhen Shen, Xiaolin Ji, Qi Li, Anshi Wu
Postoperative cognitive dysfunction (POCD) is a common postoperative complication observed in elderly patients. Using microarray analyses, we comprehensively compared long non-coding RNA (lncRNA), messenger RNA (mRNA), and microRNA (miRNA) expression profiles in hippocampal tissues from a mouse model of POCD and control mice. A total of 175 lncRNAs, 117 mRNAs, and 26 miRNAs were differentially expressed between POCD and control mice. Gene ontology (GO) and KEGG pathway enrichment analyses were performed to explore the principal functions of dysregulated genes...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28887321/lncrna-pagbc-acts-as-a-microrna-sponge-and-promotes-gallbladder-tumorigenesis
#15
Xiang-Song Wu, Fang Wang, Huai-Feng Li, Yun-Ping Hu, Lin Jiang, Fei Zhang, Mao-Lan Li, Xu-An Wang, Yun-Peng Jin, Yi-Jian Zhang, Wei Lu, Wen-Guang Wu, Yi-Jun Shu, Hao Weng, Yang Cao, Run-Fa Bao, Hai-Bin Liang, Zheng Wang, Yi-Chi Zhang, Wei Gong, Lei Zheng, Shu-Han Sun, Ying-Bin Liu
Long noncoding RNAs (lncRNAs) play roles in the development and progression of many cancers; however, the contributions of lncRNAs to human gallbladder cancer (GBC) remain largely unknown. In this study, we identify a group of differentially expressed lncRNAs in human GBC tissues, including prognosis-associated gallbladder cancer lncRNA (lncRNA-PAGBC), which we find to be an independent prognostic marker in GBC Functional analysis indicates that lncRNA-PAGBC promotes tumour growth and metastasis of GBC cells...
October 2017: EMBO Reports
https://www.readbyqxmd.com/read/28857308/a-novel-splicing-isoform-of-protein-arginine-methyltransferase-1-prmt1-that-lacks-the-dimerization-arm-and-correlates-with-cellular-malignancy
#16
Odysseas Patounas, Ioanna Papacharalampous, Carmen Eckerich, Georgios S Markopoulos, Evangelos Kolettas, Frank O Fackelmayer
Methylation of arginine residues is an important modulator of protein function that is involved in epigenetic gene regulation, DNA damage response and RNA maturation, as well as in cellular signaling. The enzymes that catalyze this post-translational modification are called protein arginine methyltransferases (PRMTs), of which PRMT1 is the predominant enzyme. Human PRMT1 has previously been shown to occur in seven splicing isoforms, which are differentially abundant in different tissues, and have distinct substrate specificity and intracellular localization...
August 31, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28813705/the-lncrna-tug1-ezh2-axis-promotes-pancreatic-cancer-cell-proliferation-migration-and-emt-phenotype-formation-through-sponging-mir-382
#17
Liang Zhao, Hongwei Sun, Hongru Kong, Zongjing Chen, Bicheng Chen, Mengtao Zhou
BACKGROUND/AIMS: Pancreatic carcinoma (PC) is the one of the most common and malignant cancers worldwide. LncRNA taurine upregulated gene 1 (TUG1) was initially identified as a transcript upregulated by taurine, and the abnormal expression of TUG1 has been reported in many cancers. However, the biological role and molecular mechanism of TUG1 in PC still needs further investigation. METHODS: Quantitative real-time PCR (qRT-PCR) was performed to measure the expression of TUG1 in PC cell lines and tissues...
2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28793054/revealing-potential-long-non-coding-rna-biomarkers-in-lung-adenocarcinoma-using-long-non-coding-rna-mediated-competitive-endogenous-rna-network
#18
T-G Zhu, X Xiao, Q Wei, M Yue, L-X Zhang
In our study, we aimed to reveal potential long non-coding RNAs (lncRNA) biomarkers in lung adenocarcinoma (LAD) using lncRNA-mediated competing endogenous RNAs (ceRNAs) network (LMCN). Competing lncRNA-mRNA interactions were identified using the hypergeometric test. Co-expression analysis for the competing lncRNA-mRNA interactions was implemented, and relying on the weight value >0.8, a highly competitive LMCN was further constructed. Degree distribution, betweenness and closeness for LMCN were carried out to analyze the network structure...
August 7, 2017: Brazilian Journal of Medical and Biological Research, Revista Brasileira de Pesquisas Médicas e Biológicas
https://www.readbyqxmd.com/read/28789966/pecanex-functions-as-a-competitive-endogenous-rna-of-s-phase-kinase-associated-protein-2-in-lung-cancer
#19
Jingqiu Li, Haihua Tian, Jinchang Pan, Nan Jiang, Jie Yang, Chengwei Zhou, Dazhi Xu, Xiaodan Meng, Zhaohui Gong
Investigating the RNA-RNA interactions involving in the initiation and progression of non-small cell lung cancer (NSCLC) may provide promising diagnostic and targeted therapeutic strategies. Here, we showed that pecanex (PCNX) positively regulates the mRNA and protein expressions of S-phase kinase associated protein 2 (Skp2) in miRNA- and 3' UTR-dependent manners. And miR-26, miR-182, miR-340 and miR-506 were verified as the common miRNAs shared by Skp2 and PCNX. Intriguingly, we initially uncovered that PCNX-3' UTR promotes cell growth, proliferation and cell cycle progression, and suppresses apoptosis of lung cancer cells, which is consistent with the oncogenic activity of Skp2-3' UTR...
October 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28744139/the-long-noncoding-rna-tincr-functions-as-a-competing-endogenous-rna-to-regulate-pdk1-expression-by-sponging-mir-375-in-gastric-cancer
#20
Zhaoliang Chen, Hong Liu, Huili Yang, Yukai Gao, Gongwen Zhang, Jiaojiao Hu
BACKGROUND: Accumulating evidence indicates that the long noncoding RNA, TINCR, plays a critical role in cancer progression and metastasis. However, the overall biological role and mechanisms of TINCR that were involved in human gastric cancer (GC) progression remain largely unknown. METHODS: TINCR expression was measured in 56 paired tumor and adjacent nontumor tissue samples by real-time polymerase chain reaction (PCR). Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were gained from bioinformatic analysis, luciferase assays...
2017: OncoTargets and Therapy
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