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Competitive endogenous RNA

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https://www.readbyqxmd.com/read/29782349/lncrna-malat-1-competitively-regulates-mir-124-to-promote-emt-and-development-of-non-small-cell-lung-cancer
#1
Jiasheng Wu, Yueyue Weng, Fei He, Dong Liang, Lin Cai
This study was carried out to explore the mechanism of LncRNA MALAT-1 as a competing endogenous RNA to regulate miR-124 in epithelial-mesenchymal transition and development of non-small-cell lung cancer (NSCLC). NSCLC and adjacent tissues were collected for RT-qPCR. The correlation of MALAT-1 and miR-124 was analyzed by Pearson. MALAT-1 expression was measured in NSCLC A549, NCI-H460, NCI-H529, SK-MES-1 cells, and 16HBE cells. A549 cells were selected for cell transfection experiments after the creation of six groups...
May 18, 2018: Anti-cancer Drugs
https://www.readbyqxmd.com/read/29774079/long-non-coding-rnas-ac026904-1-and-uca1-a-one-two-punch-for-tgf-%C3%AE-induced-snai2-activation-and-epithelial-mesenchymal-transition-in-breast-cancer
#2
Guo-Yin Li, Wei Wang, Jian-Yong Sun, Bo Xin, Xiang Zhang, Ting Wang, Qian-Feng Zhang, Li-Bo Yao, Hua Han, Dai-Ming Fan, An-Gang Yang, Lin-Tao Jia, Lei Wang
Transforming growth factor-β (TGF-β) has received much attention as a major inducer of epithelial-mesenchymal transition (EMT) during cancer progression, mainly by activating a set of pleiotropic transcription factors including SNAI2/Slug. However, the involvement of long non-coding RNAs (lncRNAs) in TGF-β-induced Slug activation and EMT remains largely unknown. Methods: In this study, we used microarray analysis to compare lncRNA expression profiles between TGF-β treated and untreated breast cancer cells...
2018: Theranostics
https://www.readbyqxmd.com/read/29764361/ouroboros-resembling-competitive-endogenous-loop-orcel-in-circular-rnas-revealed-through-transcriptome-sequencing-dataset-analysis
#3
Yu-Chen Liu, Hsiao-Chin Hong, Chi-Dung Yang, Wei-Hsiang Lee, Hsin-Tzu Huang, Hsien-Da Huang
BACKGROUND: Emerging evidence indicates that Circular RNAs (circRNAs) exert post-transcriptional regulation of gene expression. A subclass of circRNA was found enriched with miRNA target sites. This evidence suggests that this kind of circRNA functions as natural miRNA sponge. Noticing the potential impacts of circular RNA research, we were motivated to identify novel circRNAs as well as putative circRNA-miRNA interactions through retroactive sourced transcriptome sequencing samples. RESULTS: Through the analysis in 465 RNA-seq runs and 22 reports published in recent years, putatively circRNA sponged miRNA that had been experimentally verified targeting circRNA host gene were found...
May 9, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29753317/long-noncoding-rna-dancr-working-as-a-competitive-endogenous-rna-promotes-rock1-mediated-proliferation-and-metastasis-via-decoying-of-mir-335-5p-and-mir-1972-in-osteosarcoma
#4
Yong Wang, Xiandong Zeng, Ningning Wang, Wei Zhao, Xi Zhang, Songling Teng, Yueyan Zhang, Zhi Lu
BACKGROUND: Accumulating evidences indicate that non-coding RNAs (ncRNAs) including long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) acting as crucial regulators in osteosarcoma (OS). Previously, we reported that Rho associated coiled-coil containing protein kinase 1 (ROCK1), a metastatic-related gene was negatively regulated by microRNA-335-5p (miR-335-5p) and work as an oncogene in osteosarcoma. Whether any long non-coding RNAs participate in the upstream of miR-335-5p/ROCK1 axial remains unclear...
May 12, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29741786/reconstruction-and-analysis-of-the-aberrant-lncrna-mirna-mrna-network-based-on-competitive-endogenous-rna-in-cesc
#5
Jukun Song, Aizhu Ye, Enli Jiang, Xinhai Yin, Zhu Chen, Guohui Bai, Yu Zhou, Jianguo Liu
A growing body of studies has demonstrated that long non-coding RNA (lncRNA) are regarded as the primary section of the ceRNA network. This is thought to be the case owing to its regulation of protein-coding gene expression by functioning as miRNA sponges. However, functional roles and regulatory mechanisms of lncRNA-mediated ceRNA in cervical squamous cell carcinoma (CESC), as well as their use for potential prediction of CESC prognosis, remains unknown. The aberrant expression profiles of mRNA, lncRNA, and miRNA of 306 cervical squamous cancer tissues and three adjacent cervical tissues were obtained from the TCGA database...
May 9, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29736319/lncrna-malat1-promotes-tumor-growth-and-metastasis-by-targeting-mir-124-foxq1-in-bladder-transitional-cell-carcinoma-btcc
#6
Dechao Jiao, Zongming Li, Ming Zhu, Yanli Wang, Gang Wu, Xinwei Han
Mounting evidence shows that the long non-coding RNA MALAT1 plays a pivotal role in tumorigenesis and metastasis, but the functional significance of MALAT1 in bladder transitional cell carcinoma (BTCC) remains unclear. MALAT1 expression was measured in 56 BTCC patients and 2 BTCC cell lines by real-time PCR. The effects of MALAT1 on BTCC cells were investigated by over-expression approaches in vitro and in vivo . Insights of the mechanism of competitive endogenous RNAs (ceRNAs) were validated through bioinformatic analysis and luciferase assay...
2018: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29723509/long-non-coding-rna-uca1-upregulation-promotes-the-migration-of-hypoxia-resistant-gastric-cancer-cells-through-the-mir-7-5p-egfr-axis
#7
Zichang Yang, Xiaonan Shi, Ce Li, Xiaoxun Wang, Kezuo Hou, Zhi Li, Xiaojie Zhang, Yibo Fan, Xiujuan Qu, Xiaofang Che, Yunpeng Liu
A variety of solid tumors are surrounded by a hypoxic microenvironment, which is known to be associated with high metastatic capability and resistance to various clinical therapies, contributing to a poor survival rate for cancer patients. Although the majority of previous studies on tumor-associated hypoxia have focused on acute hypoxia, chronic hypoxia more closely mimics the actual hypoxic microenvironment of a tumor. In this study, two novel hypoxia-resistant gastric cancer (HRGC) cell lines which could grow normally in 2% oxygen were established...
April 30, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29720189/lncrna-mt1jp-functions-as-a-cerna-in-regulating-fbxw7-through-competitively-binding-to-mir-92a-3p-in-gastric-cancer
#8
Gang Zhang, Shuwei Li, Jiafei Lu, Yuqiu Ge, Qiaoyan Wang, Gaoxiang Ma, Qinghong Zhao, Dongdong Wu, Weida Gong, Mulong Du, Haiyan Chu, Meilin Wang, Aihua Zhang, Zhengdong Zhang
BACKGROUND: Emerging evidence has shown that dysregulation function of long non-coding RNAs (lncRNAs) implicated in gastric cancer (GC). However, the role of the differentially expressed lncRNAs in GC has not fully explained. METHODS: LncRNA expression profiles were determined by lncRNA microarray in five pairs of normal and GC tissues, further validated in another 75 paired tissues by quantitative real-time PCR (qRT-PCR). Overexpression of lncRNA MT1JP was conducted to assess the effect of MT1JP in vitro and in vivo...
May 2, 2018: Molecular Cancer
https://www.readbyqxmd.com/read/29706607/identifying-circrna-associated-cerna-networks-in-the-hippocampus-of-a%C3%AE-1-42-induced-alzheimer-s-disease-like-rats-using-microarray-analysis
#9
Zhe Wang, Panpan Xu, Biyue Chen, Zheyu Zhang, Chunhu Zhang, Qiong Zhan, Siqi Huang, Zi-An Xia, Weijun Peng
Alzheimer's disease (AD) is the most common form of dementia worldwide. Accumulating evidence indicates that non-coding RNAs are strongly implicated in AD-associated pathophysiology. However, the role of these ncRNAs remains largely unknown. In the present study, we used microarray analysis technology to characterize the expression patterns of circular RNAs (circRNAs), microRNAs (miRNAs), and mRNAs in hippocampal tissue from Aβ1-42 -induced AD model rats, to integrate interaction data and thus provide novel insights into the mechanisms underlying AD...
April 27, 2018: Aging
https://www.readbyqxmd.com/read/29702599/noncoding-rna-rna-regulatory-networks-in-cancer
#10
REVIEW
Jia Jia Chan, Yvonne Tay
Noncoding RNAs (ncRNAs) constitute the majority of the human transcribed genome. This largest class of RNA transcripts plays diverse roles in a multitude of cellular processes, and has been implicated in many pathological conditions, especially cancer. The different subclasses of ncRNAs include microRNAs, a class of short ncRNAs; and a variety of long ncRNAs (lncRNAs), such as lincRNAs, antisense RNAs, pseudogenes, and circular RNAs. Many studies have demonstrated the involvement of these ncRNAs in competitive regulatory interactions, known as competing endogenous RNA (ceRNA) networks, whereby lncRNAs can act as microRNA decoys to modulate gene expression...
April 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29700819/circular-rna-expression-profile-and-potential-function-of-hsa_circ_0045272-in-systemic-lupus-erythematosus
#11
Lian-Ju Li, Zhi-Wei Zhu, Wei Zhao, Sha-Sha Tao, Bao-Zhu Li, Shu-Zhen Xu, Jie-Bing Wang, Ming-Yue Zhang, Jun Wu, Rui-Xue Leng, Yin-Guang Fan, Hai-Feng Pan, Dong-Qing Ye
Circular RNAs (circRNAs) represent a class of non-coding RNAs that form covalently closed RNA circles with extensive expression and conservation in mammals. Circular RNAs regulate gene expression through acting as competitive endogenous RNAs (ceRNAs) and modulating gene transcription. Accumulating evidence supports the implication of circRNAs in a variety of human diseases, but studies of circRNA role in systemic lupus erythematosus (SLE) are lacking. The present study measured the circRNA expression profiles in T cells from patients with SLE and healthy controls with human circRNA microarray and identified 127 differentially expressed circRNAs in SLE patients...
April 26, 2018: Immunology
https://www.readbyqxmd.com/read/29692777/long-non-coding-rna-gaplinc-promotes-tumor-like-biologic-behaviors-of-fibroblast-like-synoviocytes-as-microrna-sponging-in-rheumatoid-arthritis-patients
#12
Bi Yao Mo, Xing Hua Guo, Meng Ru Yang, Fang Liu, Xuan Bi, Yan Liu, Lin Kai Fang, Xi Qing Luo, Julie Wang, Joseph A Bellanti, Yun Feng Pan, Song Guo Zheng
Rapidly accumulating evidence has now suggested that the long non-coding RNAs (LncRNAs), a large and diverse class of non-coding transcribed RNA molecules with diverse functional roles and mechanisms, play a major role in the pathogenesis of many human inflammatory diseases. Although some LncRNAs are overexpressed in plasma, T cell, and synovial tissues of patients with rheumatoid arthritis (RA), there is a dearth of knowledge in what role these transcripts play in fibroblast-like synoviocytes (FLSs) of these patients...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29685003/long-non-coding-rna-snhg16-contributes-to-glioma-malignancy-by-competitively-binding-mir-20a-5p-with-e2f1
#13
B Y Yang, Q Meng, Y Sun, L Gao, J X Yang
Glioma is among the most fatal and highly aggressive primary malignant tumors in the central nervous system. Small nucleolar RNA host gene 16 (SNHG16) is identified to play an oncogenic role in several cancers. However, the exact mechanism of SNHG16 action in the regulation of glioma development remains unknown. LncRNA SNHG16 was increased in glioma tissues and cells compared with normal brain tissues and cells. SNHG16 expression was correlated with the malignancy and poor prognosis of glioma patients. SNHG16 and E2F1 contained a binding site of miR-20a-5p...
March 2018: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29683732/lncrna-pfal-promotes-lung-fibrosis-through-ctgf-by-competitively-binding-mir-18a
#14
Xuelian Li, Tong Yu, Huitong Shan, Hua Jiang, Jian Sun, Xiaoguang Zhao, Wei Su, Lida Yang, Hongli Shan, Haihai Liang
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic parenchymal lung disease of unknown etiology and lacks an effective intervention. Long noncoding RNAs (lncRNAs) participate in organ fibrosis and various pulmonary diseases, but the role of lncRNAs in lung fibrosis is not fully understood. In the present study, we identified that lncRNA NONMMUT021928, designated as pulmonary fibrosis-associated lncRNA (PFAL), was up-regulated in the lungs of mice with experimental lung fibrosis, and in TGF-β1-induced fibrotic lung fibroblasts...
April 23, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29678573/long-non-protein-coding-rna-dancr-functions-as-a-competing-endogenous-rna-to-regulate-osteoarthritis-progression-via-mir-577-sphk2-axis
#15
Xiaochen Fan, Jishan Yuan, Jun Xie, Zhanpeng Pan, Xiang Yao, Xiangyi Sun, Pin Zhang, Lei Zhang
Long noncoding RNAs (lncRNAs) have been known to be involved in multiple diverse diseases, including osteoarthritis (OA). This study aimed to explore the role of differentiation antagonizing non-protein coding RNA (DANCR) in OA and identify the potential molecular mechanisms. The expression of DANCR in cartilage samples from patients with OA was detected using quantitative reverse transcription-polymerase chain reaction. The effects of DANCR on the viability of OA chondrocytes and apoptosis were explored using cell counting kit 8 assay and flow cytometry assay, respectively...
April 17, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29666238/rapid-acquisition-and-model-based-analysis-of-cell-free-transcription-translation-reactions-from-nonmodel-bacteria
#16
Simon J Moore, James T MacDonald, Sarah Wienecke, Alka Ishwarbhai, Argyro Tsipa, Rochelle Aw, Nicolas Kylilis, David J Bell, David W McClymont, Kirsten Jensen, Karen M Polizzi, Rebekka Biedendieck, Paul S Freemont
Native cell-free transcription-translation systems offer a rapid route to characterize the regulatory elements (promoters, transcription factors) for gene expression from nonmodel microbial hosts, which can be difficult to assess through traditional in vivo approaches. One such host, Bacillus megaterium , is a giant Gram-positive bacterium with potential biotechnology applications, although many of its regulatory elements remain uncharacterized. Here, we have developed a rapid automated platform for measuring and modeling in vitro cell-free reactions and have applied this to B...
April 17, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29651107/circular-rna-circ-4099-is-induced-by-tnf-%C3%AE-and-regulates-ecm-synthesis-by-blocking-mir-616-5p-inhibition-of-sox9-in-intervertebral-disc-degeneration
#17
Hua Wang, Peiheng He, Hehai Pan, Jun Long, Jianru Wang, Zemin Li, Hui Liu, Weiying Jiang, Zhaomin Zheng
Circular RNAs (circRNAs) play important roles in the initiation and development of different diseases. Here, we detected their role in intervertebral disc (IVD) degeneration. An Arraystar human circular RNA microarray assay was used to detect circRNAs in normal and degenerated human IVD nucleus pulposus (NP) tissues. The role of circ-4099 in IVDD and its mechanism were evaluated by qRT-PCR and gain-of-function/loss-of-function studies. Interaction networks for competing endogenous RNAs (ceRNAs), miRNAs, and miRNA target gene were detected by bioinformatics analysis, RNA immunoprecipitation and luciferase assay...
April 13, 2018: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/29593420/novel-long-noncoding-rna-gacat3-promotes-colorectal-cancer-cell-proliferation-invasion-and-migration-through-mir-149
#18
Weiwei Zhou, Lei Wang, Yu Miao, Rongge Xing
Aim: To explore the expression and clinical significance of long noncoding RNA (lncRNA) gastric cancer-associated transcript 3 (GACAT3) in human colorectal cancer (CRC). Methods: Expression of GACAT3 in CRC tissues and cell lines was measured using quantitative real-time PCR. CCK-8 and colony formation assays were used to assess the effect of GACAT3 on CRC cell line proliferation. Transwell invasion and migration assays were performed to detect the effect of GACAT3 on CRC cell line invasion and migration...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29577053/hsa_circ_0001859-regulates-atf2-expression-by-functioning-as-an-mir-204-211-sponge-in-human-rheumatoid-arthritis
#19
Bingrui Li, Nianyu Li, Le Zhang, Kai Li, Yingtian Xie, Meilan Xue, Zheng Zheng
Background: circRNAs are part of the competitive endogenous RNA network, which putatively function as miRNA sponges and play a crucial role in the development of numerous diseases. However, studies of circRNAs in rheumatoid arthritis (RA) disease are limited. This work aims to identify the expression pattern of circRNAs in synovial tissues and their inflammatory regulation mechanism. Methods: We first compared the mRNA expression in rheumatoid arthritis patients with that in healthy volunteers by GEO database mining to identify gene loci specifically expressed in synovial tissues...
2018: Journal of Immunology Research
https://www.readbyqxmd.com/read/29552284/competitive-endogenous-rna-networks-integrated-analysis-of-non-coding-rna-and-mrna-expression-profiles-in-infantile-hemangioma
#20
Jun Li, Qian Li, Ling Chen, Yanli Gao, Bei Zhou, Jingyun Li
Infantile hemangioma (IH) is the most common vascular tumour in infants. The pathogenesis of IH is complex and poorly understood. Therefore, achieving a deeper understanding of IH pathogenesis is of great importance. Here, we used the Ribo-Zero RNA-Seq and HiSeq methods to examine the global expression profiles of protein-coding transcripts and non-coding RNAs, including miRNAs and lncRNAs, in IH and matched normal skin controls. Bioinformatics assessments including gene ontology (GO) and kyoto encyclopedia of genes and genomes (KEGG) pathway analyses were performed...
February 23, 2018: Oncotarget
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