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https://www.readbyqxmd.com/read/28098826/hair-growth-promoting-and-anticancer-effects-of-p21-activated-kinase-1-pak1-inhibitors-isolated-from-different-parts-of-alpinia-zerumbet
#1
Nozomi Taira, Binh Cao Quan Nguyen, Shinkichi Tawata
PAK1 (p21-activated kinase 1) is an emerging target for the treatment of hair loss (alopecia) and cancer; therefore, the search for PAK1 blockers to treat these PAK1-dependent disorders has received much attention. In this study, we evaluated the anti-alopecia and anticancer effects of PAK1 inhibitors isolated from Alpinia zerumbet (alpinia) in cell culture. The bioactive compounds isolated from alpinia were found to markedly promote hair cell growth. Kaempferol-3-O-β-d-glucuronide (KOG) and labdadiene, two of the isolated compounds, increased the proliferation of human follicle dermal papilla cells by approximately 117%-180% and 132%-226%, respectively, at 10-100 μM...
January 14, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28097624/poorly-differentiated-adenocarcinoma-with-signet-ring-cells-in-duodenal-papilla-a-case-report
#2
Yuta Ushida, Kiyoshi Hiramatsu, Satomi Saeki, Takeshi Amemiya, Hidenari Goto, Toshiyuki Arai
An 82-year-old woman with common bile duct (CBD) dilatation observed during routine ultrasonography was referred to our hospital. Preliminary blood tests revealed elevated levels of hepatobiliary enzymes. Computed tomography (CT) scan showed lower bile duct wall thickening and enhancement. Esophagogastroduodenoscopy revealed mildly swollen papilla of Vater, without ulceration. Endoscopic retrograde cholangiography demonstrated that the CBD was grossly dilated with a constriction in the lower part. The final diagnosis indicated poorly differentiated adenocarcinoma of duodenal papilla with signet-ring cells; pT3N0M0, stage IIA (Unio Internationalis Contra Cancrum, 7th edition), for which subtotal stomach-preserving pancreaticoduodenectomy (SSPPD) was performed...
December 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/28097623/toward-a-functional-definition-of-ankyloglossia-validating-current-grading-scales-for-lingual-frenulum-length-and-tongue-mobility-in-1052-subjects
#3
Audrey Yoon, Soroush Zaghi, Rachel Weitzman, Sandy Ha, Clarice S Law, Christian Guilleminault, Stanley Y C Liu
PURPOSE: Alterations of the lingual frenulum may contribute to oromyofacial dysfunction, speech and swallowing impediments, underdevelopment of the maxillofacial skeleton, and even predispose to sleep breathing disorder. This study aims to assess the utility of existing instruments for evaluation of restricted tongue mobility, describe normal and abnormal ranges of tongue mobility, and provide evidence in support of a reliable and efficient measure of tongue mobility. METHODS: A prospective cohort study of 1052 consecutive patients was evaluated during a 3-month period...
January 17, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28095024/pathologic-subtypes-of-ampullary-adenocarcinoma-value-of-ampullary-mdct-for-noninvasive-preoperative-differentiation
#4
Aleksandar M Ivanovic, Francesco Alessandrino, Ruzica Maksimovic, Marjan Micev, Slavenko Ostojic, Richard M Gore, Koenraad J Mortele
OBJECTIVE: The purpose of this study was to evaluate the utility of ampullary MDCT in the noninvasive, preoperative differentiation of pancreatobiliary and intestinal subtypes of ampullary adenocarcinoma. MATERIALS AND METHODS: This retrospective study included 32 patients (20 men, 12 women; age range, 41-81 years) with resected ampullary adenocarcinoma who underwent preoperative contrast-enhanced ampullary MDCT. Two radiologists, blinded to pathologic diagnosis of adenocarcinoma subtype, evaluated the presence of seven MDCT features independently...
January 17, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/28094661/diagnosis-of-pancreatic-disease-in-feline-platynosomosis
#5
Liza S Köster, Linda Shell, Jennifer Ketzis, Sreekumari Rajeev, Oscar Illanes
Objectives Platynosomum species are cat-specific parasitic trematodes that parasitize the biliary ducts and gall bladder. Due to the common connection to the major duodenal papilla of the pancreas and common bile ducts in addition to the periductal proximity of the pancreas, it is possible that platynosomosis could cause pancreatitis. The objective of this study was to determine whether platynosomosis, a commonly diagnosed parasitic disease in cats on St Kitts, has any association with pancreatic disease. Methods To investigate this possibility, the pancreas of free-roaming cats with naturally acquired platynosomosis were evaluated via ultrasound, serum concentrations of feline pancreatic lipase (fPL), cobalamin, folate and feline trypsin-like immunoreactivity (fTLI) and histopathology...
January 1, 2017: Journal of Feline Medicine and Surgery
https://www.readbyqxmd.com/read/28093668/molecular-characterization-of-hoxc8-gene-and-methylation-status-analysis-of-its-exon-1-associated-with-the-length-of-cashmere-fiber-in-liaoning-cashmere-goat
#6
Wen L Bai, Jiao J Wang, Rong H Yin, Yun L Dang, Ze Y Wang, Yu B Zhu, Yu Y Cong, Liang Deng, Dan Guo, Shi Q Wang, Shu H Yang, Hui L Xue
Homeobox protein Hox-C8 (HOXC8) is a member of Hox family. It is expressed in the dermal papilla of the skin and is thought to be associated with the hair inductive capacity of dermal papilla cells. In the present study, we isolated and characterized a full-length open reading frame of HOXC8 cDNA from the skin tissue of Liaoning cashmere goat, as well as, established a phylogenetic relationship of goat HOXC8 with that of other species. Also, we investigated the effect of methylation status of HOXC8 exon 1 at anagen secondary hair follicle on the cashmere fiber traits in Liaoning cashmere goat...
January 16, 2017: Genetica
https://www.readbyqxmd.com/read/28093319/anti-inflammatory-effect-of-the-salvia-sclarea-l-ethanolic-extract-on-lipopolysaccharide-induced-periodontitis-in-rats
#7
Milica Kostić, Dušanka Kitić, Milica B Petrović, Tatjana Jevtović-Stojmenov, Marko Jović, Aleksandar Petrović, Slavoljub Živanović
ETHNOPHARMACOLOGICAL RELEVANCE: Salvia sclarea L., clary, is an aromatic plant traditionally used in folk medicine for the treatment of various diseases and conditions. Although it has been primarily used as a stomachic, there are data on traditional use of S. sclarea as an agent against gingivitis, stomatitis and aphthae. AIM OF THE STUDY: The aim of the study was to examine the effect of the S. sclarea ethanolic extract on the lipopolysaccharide (LPS)-induced periodontitis in rats from the immunological and histopathological standpoint...
January 13, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28087026/dermoscopy-of-pigmented-fungiform-papillae-of-the-tongue
#8
Juan-Carlos Robles-Méndez, Ana-Sofía Ayala-Cortés, Alejandra Villarreal-Martínez, Jorge Ocampo-Candiani
No abstract text is available yet for this article.
February 2017: Journal of the American Academy of Dermatology
https://www.readbyqxmd.com/read/28076484/an-innovative-ex-vivo-model-for-rapid-change-of-the-papilla-for-teaching-advanced-endoscopic-retrograde-cholangiopancreatography-procedures
#9
Everson L A Artifon, Thaisa S Nakadomari, Leandro Y Kashiwagui, Emilio A Belmonte, Cláudio R Solak, Spencer Cheng, Carlos K Furuya, Jose P Otoch
Background: Models for endoscopic retrograde cholangiopancreatography training allow practice with an expert feedback and without risks. A method to rapidly exchange the papilla can be time saving and accelerate the learning curve. Aim: To demonstrate a newly method of rapid exchange papilla in ex-vivo models to teach retrograde cholangiopancreatography advanced procedures. Methods: A new model of ex-vivo papilla was developed in order to resemble live conditions of procedures as cannulation, papilotomy or fistula-papilotomy, papiloplasty, biliary dilatation, plastic and metallic stentings...
November 2016: Arquivos Brasileiros de Cirurgia Digestiva: ABCD, Brazilian Archives of Digestive Surgery
https://www.readbyqxmd.com/read/28074885/first-objective-evaluation-of-taste-sensitivity-to-6-n-propylthiouracil-prop-a-paradigm-gustatory-stimulus-in-humans
#10
Giorgia Sollai, Melania Melis, Danilo Pani, Piero Cosseddu, Ilenia Usai, Roberto Crnjar, Annalisa Bonfiglio, Iole Tomassini Barbarossa
Practical and reliable methods for the objective measure of taste function are critically important for studying eating behavior and taste function impairment. Here, we present direct measures of human gustatory response to a prototypical bitter compound, 6-n-propyltiouracil (PROP), obtained by electrophysiological recordings from the tongue of subjects who were classified for taster status and genotyped for the specific receptor gene (TAS2R38), and in which taste papilla density was determined. PROP stimulation evoked negative slow potentials that represent the summated depolarization of taste cells...
January 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28062989/angiostoma-norvegicum-n-sp-nematoda-angiostomatidae-a-parasite-of-arionid-slugs-in-norway
#11
Jenna L Ross, Solveig Haukeland, Bjørn A Hatteland, Elena S Ivanova
Angiostoma norvegicum n. sp. (Angiostomatidae) is described from the oesophagus, crop and the buccal mass of five species of slugs of the family Arionidae, Arion vulgaris (Moquin-Tandon), Arion ater (L.), Arion fasciatus (Nilsson), Arion fuscus (Müller) and Arion rufus/Arion ater hybrid), collected throughout Norway. Angiostoma norvegicum n. sp. was found parasitising arionids at seven of the 30 sample sites examined (23.3%), and 9.9% of all Arion spp. were infected with this nematode. The new species is characterised by its large size (4...
January 2017: Systematic Parasitology
https://www.readbyqxmd.com/read/28062869/-large-balloon-dilation-for-removal-of-choledocholithiasis-difficult-to-extract-clinical-experience
#12
Luis Marin Calderón, Augusto Vera Calderón, Aldo Gómez Correa, Zenon Cervera Reyes, Milagros Dávalos Moscol, Edgar Alva Alva, Fernando Palacios Salas, Ramiro Díaz Ríos, Edson Guzmán Calderón, Grisley García Chihuan
OBJECTIVE: The aim of this study was to report the initial experience of the combined use of biliary sphincterotomy plus balloon dilatation of the papilla for management of large stones. MATERIALS AND METHODS: Design: Retrospective, descriptive. This study included 18 patients in whom a hydrostatic dilatation of the papilla with large balloons was performed between June 2012 and April 2014. Patients had multiple large stones, tapered distal common bile duct, previous sphincterotomy, or peri/ intradiverticular papilla...
October 2016: Revista de Gastroenterología del Perú: órgano Oficial de la Sociedad de Gastroenterología del Perú
https://www.readbyqxmd.com/read/28054178/hemosuccus-pancreaticus-caused-by-a-mucinous-cystic-neoplasm-of-the-pancreas
#13
Yuri Matsumoto, Hiroshi Miyamoto, Akira Fukuya, Fumika Nakamura, Takahiro Goji, Shinji Kitamura, Tetsuo Kimura, Koichi Okamoto, Masahiro Sogabe, Naoki Muguruma, Mitsuo Shimada, Yoshimi Bando, Tetsuji Takayama
Hemosuccus pancreaticus is a gastrointestinal hemorrhage through the main pancreatic duct. Here, we report a rare case of hemosuccus pancreaticus due to a mucinous cystic neoplasm of the pancreas. A 62-year-old woman who had been followed for a branch duct intraductal papillary mucinous neoplasm visited our emergency room due to severe abdominal pain and bloody discharge. Computed tomography revealed that the pancreatic cyst increased the tension of the wall and a high-density area indicative of bleeding into the cyst was observed...
January 4, 2017: Clinical Journal of Gastroenterology
https://www.readbyqxmd.com/read/28051910/transperitoneal-intravesical-technique-for-laparoscopic-ureteral-reimplantation-to-treat-terminal-ureteral-stenosis
#14
Bing-Sheng Li, Yao He, Zhi Chen, Zhao-Hui Wang, Zhi-Qiang Wen, Xiang Chen
OBJECTIVE: To describe a newly developed transperitoneal intravesical technique for laparoscopic ureteral reimplantation in patients with terminal ureteral stenosis. METHODS: Between July 2009 and May 2015, laparoscopic transperitoneal intravesical ureteral reimplantation was performed in 16 patients with terminal ureteral stenosis without vesicoureteral reflux (VUR). An incision was made in the superior bladder wall of the affected side with an electric hook. The bladder mucosa was then circumferentially cut away from the ureteral orifice to a distance of 0...
January 4, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28050328/cataract-surgery-after-retinal-detachment-surgery-with-arruga-s-sutures-case-report
#15
Erkan Ünsal, Kadir Eltutar, Osman Kızılay, Belma Karini
A 56-year old female patient presented to our clinic with a complaint of low vision in her right eye. Twenty-two years earlier she had undergone a scleral buckling operation in her right eye because of retinal detachment. She indicated that vision in her right eye was good after the surgery but had recently been gradually declining. Best-corrected vision acuity was counting fingers at 1 meter in the right eye and 8/10 in the left eye. Anterior segment examination revealed stage 3 nuclear cataract in the right eye...
December 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28050202/sialendoscopy-training-presentation-of-a-realistic-model
#16
Gabriela Robaskewicz Pascoto, Aldo Cassol Stamm, Marcos Lyra
Introduction Several surgical training simulators have been created for residents and young surgeons to gain experience with surgical procedures. Laboratory training is fundamental for acquiring familiarity with the techniques of surgery and skill in handing instruments. Objective The aim of this study is to present a novel simulator for training sialendoscopy. Method This realistic simulator was built with a synthetic thermo-retractile, thermo-sensible rubber which, when combined with different polymers, produces more than 30 different formulas...
January 2017: International Archives of Otorhinolaryngology
https://www.readbyqxmd.com/read/28046176/effect-of-different-feeding-regimens-on-energy-and-protein-utilization-and-partitioning-for-maintenance-and-growth-in-pre-weaned-lambs-reared-artificially
#17
A S Danso, P C H Morel, P R Kenyon, H T Blair
Estimation of metabolizable energy (ME) requirement for maintenance (ME) and growth (ME) in pre-weaned lambs have been limited to milk-only fed lambs. This study aimed to determine energy and nitrogen metabolisability of milk and pellets when fed together, compare the growth and chemical body composition of lambs fed varying levels of pellets in addition to milk, and to estimate ME, ME, and the CP:ME ratio requirements for growth. The study included 32 twin-born Romney-cross ram lambs. Four lambs were slaughtered at 24 h post-partum to estimate initial body composition and the remaining 28 were assigned to 1 of 4 treatment groups of 7...
December 2016: Journal of Animal Science
https://www.readbyqxmd.com/read/28045639/a-retrospective-cohort-study-of-glossopharyngeal-nerve-taste-in-children-with-recurrent-acute-tonsillitis
#18
Courtney A Hill, Suveera Dang, Michael Beach, Eunice Y Chen
Objective To compare glossopharyngeal taste between healthy children and those with recurrent acute tonsillitis. Study Design Retrospective cohort study. Setting Pediatric clinics in a tertiary care medical center and satellite location. Subjects and Methods Smell and taste testing was administered to 80 well children and 64 children with recurrent acute tonsillitis (age range, 6-17 years). Smell testing was performed with the NIH Toolbox Odor Identification Test, with scores based on national averages for age and sex...
January 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28041738/epimural-bacterial-community-structure-in-the-rumen-of-holstein-cows-with-different-responses-to-a-long-term-subacute-ruminal-acidosis-diet-challenge
#19
S U Wetzels, E Mann, P Pourazad, M Qumar, B Pinior, B U Metzler-Zebeli, M Wagner, S Schmitz-Esser, Q Zebeli
Subacute ruminal acidosis (SARA) is a prevalent metabolic disorder in cattle, characterized by intermittent drops in ruminal pH. This study investigated the effect of a gradual adaptation and continuously induced long-term SARA challenge diet on the epimural bacterial community structure in the rumen of cows. Eight rumen-cannulated nonlactating Holstein cows were transitioned over 1 wk from a forage-based baseline feeding diet (grass silage-hay mix) to a SARA challenge diet, which they were fed for 4 wk. The SARA challenge diet consisted of 60% concentrates (dry matter basis) and 40% grass silage-hay mix...
December 29, 2016: Journal of Dairy Science
https://www.readbyqxmd.com/read/28041686/evaluation-of-a-commercially-available-hyaluronic-acid-hydrogel-restylane-as-injectable-scaffold-for-dental-pulp-regeneration-an-in%C3%A2-vitro-evaluation
#20
Vanessa Chrepa, Obadah Austah, Anibal Diogenes
INTRODUCTION: Regenerative endodontic procedures (REPs) are viable alternatives for treating immature teeth, yet these procedures do not predictably lead to pulp-dentin regeneration. A true bioengineering approach for dental pulp regeneration requires the incorporation of a scaffold conducive with the regeneration of the pulp-dentin complex. Several materials have been proposed as scaffolds for REPs; nonetheless, the majority are not eligible for immediate clinical chairside use. Thus, the aim of this study was to evaluate Restylane, a Food and Drug Administration-approved hyaluronic acid-based gel, as possible scaffold for REPs...
December 29, 2016: Journal of Endodontics
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