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https://www.readbyqxmd.com/read/28324846/novel-alk5-inhibitor-tp0427736-reduces-tgf-%C3%AE-%C3%A3-induced-growth-inhibition-in-human-outer-root-sheath-cells-and-elongates-anagen-phase-in-mouse-hair-follicles
#1
Takumi Naruse, Mari Aoki, Natsuko Fujimoto, Seiji Arase, Hajimu Oura, Yasuji Ueda, Akiko Ikeda
BACKGROUND: Androgenic alopecia (AGA) occurs as a result of the contraction of the anagen phase because of the action of androgens on hair follicles. TGF-β production from dermal papillae is enhanced by androgens, and growth inhibition of hair-follicle cells is induced by TGF-β, and the hair cycle progresses from the anagen phase to the catagen phase. We investigated both the in vitro and in vivo potency of the newly identified ALK5 inhibitor TP0427736 {6-[4-(4-methyl-1,3-thiazol-2-yl)-1H-imidazol-5-yl]-1,3-benzothiazole}...
January 25, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/28316390/sem-studies-on-acanthocephalan-parasite-echinorhynchus-veli-infecting-the-fish-synaptura-orientalis-bl-sch-1801
#2
S H Sheema, M V John, P V George
Echinorhynchus veli (George and Nadakal, 1978), an acanthocephalid worm infesting the estuarine flat fish, Synaptura orientalis, was collected from the Veli lake, Kerala. The parasite was recovered from the intestine of the host fish. The detailed surface morphology was studied with the help of scanning electron microscope. The study revealed a cylindrical, medially swollen proboscis with a flat apex, backward directed hooks, each with smooth surface, broad base, pointed tip and an epidermal elevation at the point of insertion...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28316384/taxonomic-tools-for-the-identification-of-allogenarchopsisbareilliensis-n-sp-digenea-hemiuroidea-derogenidae-from-channastriata-of-rohilkhand-india-based-on-light-and-scanning-electron-microscopic-studies
#3
Neelima Gupta, Dileep K Gupta, Misako Urabe
The stomach of the freshwater snakehead murrel, Channastriata (n = 250) collected from fresh water habitats of Bareilly, Uttar Pradesh, India revealed Allogenarchopsis, a trematode parasite (Plagiorchiida: Derogenidae). An illustrated account of light (Olympus BX-53 with Cellsens software imaging system) and scanning electron microscopy (SEM) (Neo JCM-6000) of Allogenarchopsisbareilliensis n. sp. (prevalence 37 %, intensity 1-4 par/host) is provided. Light microscopy based studies warranting creation of a new species are the robust shape of the body with broad mid-body, blunt anterior and tapering posterior end, large ventral sucker, ratio of oral sucker: ventral sucker 1:3...
March 2017: Journal of Parasitic Diseases: Official Organ of the Indian Society for Parasitology
https://www.readbyqxmd.com/read/28301683/how-to-treat-two-adjacent-missing-teeth-with-dental-implants-a-systematic-review-on-single-implant-supported-two-unit-cantilever-fdp-s-and-results-of-a-5-year-prospective-comparative-study-in-the-aesthetic-zone
#4
Wouter G Van Nimwegen, Gerry M Raghoebar, Nynke Tymstra, Arjan Vissink, Henny J A Meijer
AIM: To conduct a systematic review on the clinical outcome of single implant-supported two-unit cantilever FDP's and to conduct a 5-year prospective comparative pilot study of patients with a missing central and lateral upper incisor treated with either a single implant-supported two-unit cantilever FDP or two implants with solitary implant crowns in the aesthetic zone. MATERIAL AND METHODS: Medline, Embase and the Cochrane Central Register of Controlled Trials were searched (last search August 1, 2016) for eligible studies...
March 16, 2017: Journal of Oral Rehabilitation
https://www.readbyqxmd.com/read/28298832/reconstruction-of-interdental-papilla-using-autogenous-bone-and-connective-tissue-grafts
#5
Santhanakrishnan Muthukumar, Pooja Ajit, Shiyamali Sundararajan, Suresh Ranga Rao
Previous studies have reported the management of Class I and II papillary defects, but knowledge on Class III defects, estimated to have a poor periodontal prognosis, remains minimal. In this case report, a Class III papillary defect reconstruction was attempted mainly since the patient reported with difficulty in phonetics. In Stage I, autogenous bone graft from the maxillary tuberosity and subepithelial connective tissue graft was augmented to decrease the distance between the interdental bone crest and contact point, simultaneously achieving a switch in the periodontal biotype...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28298831/whale-s-tail-technique-a-case-series
#6
Deshpande Milind Mrunal, Jarde Samiksha Jaypal, Rohan Srinivasan Wilson, Anirban Chatterjee
The Whale's tail technique performed to obtain maximum interdental papilla fill in the anterior region after placement of bone grafts. This study aims to assess the clinical efficacy of this new technique. This report describes a series of three cases with a probing depth of 6-7 mm in the maxillary anterior teeth and their treatment with Whale's tail technique to obtain regeneration and maximum papilla preservation. The cases in this report showed a pocket depth reduction of 3-4mm and a clinical attachment gain of 3-4mm...
July 2016: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/28296736/dermoscopic-features-of-livedoid-vasculopathy
#7
Stephen Chu-Sung Hu, Gwo-Shing Chen, Chi-Ling Lin, Yang-Chun Cheng, Yung-Song Lin
Livedoid vasculopathy (atrophie blanche) is a form of thrombotic vasculopathy. It is characterized by small ulcers that become crusted, and heal after several months to produce white atrophic scars. The most commonly affected sites are the lower legs, in particular the dorsum of the feet and ankles. To date, the dermoscopic features of livedoid vasculopathy have not been clearly described in the literature. In this observational study, we sought to evaluate the dermoscopic patterns of livedoid vasculopathy and determine whether the dermoscopic features are associated with certain histopathological characteristics...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28292191/upper-calyx-accessibility-through-a-lower-calyx-access-is-not-influenced-by-morphometric-and-clinical-factors-in-supine-percutaneous-nephrolithotomy
#8
Mario Sofer, Yazeed Barghouthy, Yuval Bar-Yosef, Ishay Mintz, Silvia Proietti, Ronit Tsemah, Amir Horkin, Haim Matzkin, Guido Giusti
OBJECTIVE: To assess whether morphometric and clinical parameters influence accessibility to the upper calyx through a lower calyx tract during supine percutaneous nephrolithotomy (SPCNL). METHODS: Data for 114 consecutive SPCNLs performed between 6/2014-3/2016 in an academic medical center were analyzed. Successful approachability was defined as rigid nephroscopic access to the upper calyx introduced through a lower calyx access as attested by direct visualization of the upper calyx papillae and position of the nephroscope on intraoperative pyelography...
March 14, 2017: Journal of Endourology
https://www.readbyqxmd.com/read/28291989/reverse-sphincterotomy-of-the-minor-papilla-via-the-major-papilla-for-chronic-pancreatitis-with-incomplete-pancreas-divisum
#9
Radhika Chavan, Rakesh Kalapala, Zaheer Nabi, Sundeep Lakhtakia, D Nageshwar Reddy
No abstract text is available yet for this article.
February 2017: Endoscopy
https://www.readbyqxmd.com/read/28291239/cap-assisted-upper-endoscopy-for-examination-of-the-major-duodenal-papilla-a-randomized-blinded-controlled-crossover-study-cappa-study
#10
Mohamed Abdelhafez, Veit Phillip, Alexander Hapfelmeier, Mayada Elnegouly, Alexander Poszler, Kilian Strobel, Peter Born, Markus Dollhopf, Abdel Meguid Kassem, Lenika Calavrezos, Peter Klare, Christoph Schlag, Monther Bajbouj, Roland M Schmid, Stefan von Delius
OBJECTIVE: Examination of major duodenal papilla (MDP) by standard forward-viewing esophagogastroduodenoscopy (S-EGD) is limited. Cap assisted esophagogastroduodenoscopy (CA-EGD) utilizes a cap fitted to the tip of the endoscope that can depress the mucosal folds and thus might improve visualization of MDP. The aim of this study was to compare CA-EGD to S-EGD for complete examination of the MDP. METHODS: Prospective, randomized, blinded, controlled crossover study...
March 14, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28287390/species-of-philometra-nematoda-philometridae-from-fishes-off-the-mediterranean-coast-of-africa-with-a-description-of-philometra-rara-n-sp-from-hyporthodus-haifensis-and-a-molecular-analysis-of-philometra-saltatrix-from-pomatomus-saltatrix
#11
František Moravec, Amira Chaabane, Lassad Neifar, Delphine Gey, Jean-Lou Justine
Two gonad-infecting species of Philometra Costa, 1845 (Nematoda, Philometridae) were recorded for the first time from marine perciform fishes off Tunisia and Libya: Philometra rara n. sp. from the rare, deep-water Haifa grouper Hyporthodus haifensis (Serranidae) off Libya and Philometra saltatrix Ramachandran, 1973 from the bluefish Pomatomus saltatrix (Pomatomidae) off Tunisia. Identification of both fish species was confirmed by molecular barcoding. Light and scanning electron microscope studies of Ph. rara n...
2017: Parasite: Journal de la Société Française de Parasitologie
https://www.readbyqxmd.com/read/28286558/optimal-biliary-access-point-and-learning-curve-for-endoscopic-ultrasound-guided-hepaticogastrostomy-with-transmural-stenting
#12
Dongwook Oh, Do Hyun Park, Tae Jun Song, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim
BACKGROUND: Although endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) with transmural stenting has increased for biliary decompression in patients with an inaccessible papilla, the optimal biliary access point and the learning curve of EUS-HGS have not been studied. We evaluated the optimal biliary access point and learning curve for technically successful EUS-HGS. METHODS: 129 consecutive patients (male n = 81, 62.3%; malignant n = 113, 87.6%) who underwent EUS-HGS due to an inaccessible papilla were enrolled...
January 2017: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/28286046/rudimentary-expression-of-ryamide-in-drosophila-melanogaster-relative-to-other-drosophila-species-points-to-a-functional-decline-of-this-neuropeptide-gene
#13
Jan A Veenstra, Hela Khammassi
RYamides are arthropod neuropeptides with unknown function. In 2011 two RYamides were isolated from D. melanogaster as the ligands for the G-protein coupled receptor CG5811. The D. melanogaster gene encoding these neuropeptides is highly unusual, as there are four RYamide encoding exons in the current genome assembly, but an exon encoding a signal peptide is absent. Comparing the D. melanogaster gene structure with those from other species, including D. virilis, suggests that the gene is degenerating. RNAseq data from 1634 short sequence read archives at NCBI containing more than 34 billion spots yielded numerous individual spots that correspond to the RYamide encoding exons, of which a large number include the intron-exon boundary at the start of this exon...
March 7, 2017: Insect Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28284700/effects-of-dietary-neutral-detergent-fiber-and-starch-ratio-on-rumen-epithelial-cell-morphological-structure-and-gene-expression-in-dairy-cows
#14
L Ma, M Zhao, L S Zhao, J C Xu, J J Loor, D P Bu
This study was designed to investigate the effect of dietary neutral detergent fiber to starch ratio on rumen epithelial morphological structure and gene expression. Eight primiparous dairy cows including 4 ruminally fistulated cows were assigned to 4 total mixed rations with neutral detergent fiber to starch ratios of 0.86, 1.18, 1.63, and 2.34 in a replicated 4 × 4 Latin square design. The duration of each period was 21 d including 14 d for adaptation and 7 d for sampling. Rumen epithelial papillae were collected from the ruminally fistulated cows for morphological structure examination and mRNA expression analysis using quantitative real-time PCR of several genes related to volatile fatty acid absorption and metabolism, and cellular growth...
March 8, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28281945/complication-after-extraction-of-natal-teeth-with-continued-growth-of-a-dental-papilla
#15
Sook Hee Kim, Young-Ah Cho, Ok Hyung Nam, Mi Sun Kim, Sung Chul Choi, Hyo-Seol Lee
The purposes of this case report were to describe a growing two-cm gingival mass that developed after natal teeth were extracted in a four-month-old female patient, present a review of the literature on the growth of a gingival mass after the extraction of natal teeth, and illustrate the clinical and histological features that differentiate this condition from other types of gingival masses in infants. Histological examination of the excised mass revealed that it contained tooth-like hard tissue (regular and irregular dentin) that intermingled with bone, dental pulp, and fibrous tissue...
November 15, 2016: Pediatric Dentistry
https://www.readbyqxmd.com/read/28281551/molecular-correlates-and-rate-of-lymph-node-metastasis-of-non-invasive-follicular-thyroid-neoplasm-with-papillary-like-nuclear-features-and-invasive-follicular-variant-papillary-thyroid-carcinoma-the-impact-of-rigid-criteria-to-distinguish-non-invasive-follicular
#16
Uiju Cho, Ozgur Mete, Min-Hee Kim, Ja Seong Bae, Chan Kwon Jung
Thyroid tumors formerly classified as non-invasive encapsulated follicular variant of papillary thyroid carcinoma were recently renamed 'non-invasive follicular thyroid neoplasm with papillary-like nuclear features'. The current study investigated the frequency of lymph node metastasis and mutational profile of encapsulated follicular variant in the setting of a clinical practice where central neck dissection was the standard of practice. We defined the impact of rigid diagnostic criteria by regrouping such tumors based on the complete absence of papillae or presence of ≤1% papillae...
March 10, 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28281120/transduodenal-transpapillary-endopancreatic-surgery-with-a-rigid-resectoscope-experiments-on-ex-vivo-in-vivo-animal-models-and-human-cadavers
#17
Philip C Müller, Daniel C Steinemann, Felix Nickel, Lukas Chinczewski, Beat P Müller-Stich, Georg R Linke, Kaspar Z'graggen
BACKGROUND: Surgery for chronic pancreatitis is afflicted with high morbidity. A novel transduodenal-transpapillary endopancreatic resection (EPR) may provide a less invasive alternative approach. MATERIALS AND METHODS: After laparoscopic duodenotomy the papilla was dilated and accessed with a rigid resectoscope. A resection of pancreatic head tissue was performed from inside the organ. First, the feasibility and resection volume were assessed in bovine pancreas...
March 9, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28280377/promotion-of-anagen-increased-hair-density-and-reduction-of-hair-fall-in-a-clinical-setting-following-identification-of-fgf5-inhibiting-compounds-via-a-novel-2-stage-process
#18
Dominic Burg, Masakuni Yamamoto, Masato Namekata, Joseph Haklani, Koichiro Koike, Maria Halasz
BACKGROUND: There are very few effective, scientifically validated treatments with known mechanisms of action for treatment of hair loss in both men and women. Fibroblast growth factor 5 (FGF5) is an important factor in the irreversible transition from anagen to catagen, and inhibition of FGF5 prolongs anagen phase and reduces hair loss. OBJECTIVE: We aimed to screen botanically derived molecules for FGF5 inhibitory activity in vitro and assess efficacy in a clinical setting...
2017: Clinical, Cosmetic and Investigational Dermatology
https://www.readbyqxmd.com/read/28277438/endoscopic-sphincterotomy-for-gallbladder-muddy-stones-or-sludge-in-patients-with-papillary-disease-a-retrospective-study
#19
Cheng Zhang, Yu-Long Yang, Yue-Feng Ma, Hong-Wei Zhang, Li-Jun Shi, Jing-Yi Li, Mei-Ju Lin, Chun-Chun Qi
BACKGROUND: The formation of gallbladder stones is associated with dysfunctional contraction and duodenal papilla diseases. However, endoscopic sphincterotomy can improve the contraction of the gallbladder and resolve duodenal papilla disease. AIM: The aim of the study was to assess the feasibility and effectiveness of endoscopic sphincterotomy in the treatment of muddy stones or sludge in the gallbladder during papillary disease. METHODS: The clinical data of 53 patients with gallbladder muddy stones or sludge undergoing endoscopic sphincterotomy were retrospectively analyzed...
March 8, 2017: Surgical Laparoscopy, Endoscopy & Percutaneous Techniques
https://www.readbyqxmd.com/read/28276195/nodular-colloid-milium-mimicking-keloid
#20
Seyyede Zeinab Azimi, Omid Zargari, Robert I Rudolph
Colloid milium is a rare cutaneous deposit disease that usually presents clinically by the development of yellowish translucent or flesh-colored papules or plaques on sun-exposed skin. Histologically, it is characterized by the presence of colloid in the dermal papillae. In this case report, we present a 52-year-old man who presented with a nodule on his upper lip that mistakenly was diagnosed and treated as keloid.
March 9, 2017: Journal of Cosmetic Dermatology
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