Yuchao Jiang, Wei Li, Jinmei Li, Xiuli Li, Heng Zhang, Xiutian Sima, Luying Li, Kang Wang, Qifu Li, Jiajia Fang, Lu Jin, Qiyong Gong, Dezhong Yao, Dong Zhou, Cheng Luo, Dongmei An
Artificial intelligence provides an opportunity to try to redefine disease subtypes based on similar pathobiology. Using a machine-learning algorithm (Subtype and Stage Inference) with cross-sectional MRI from 296 individuals with focal epilepsy originating from the temporal lobe (TLE) and 91 healthy controls, we show phenotypic heterogeneity in the pathophysiological progression of TLE. This study was registered in the Chinese Clinical Trials Registry (number: ChiCTR2200062562). We identify two hippocampus-predominant phenotypes, characterized by atrophy beginning in the left or right hippocampus; a third cortex-predominant phenotype, characterized by hippocampus atrophy after the neocortex; and a fourth phenotype without atrophy but amygdala enlargement...
March 12, 2024: Nature Communications