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https://www.readbyqxmd.com/read/28938728/modeling-of-live-birth-rates-and-cost-effectiveness-of-oocyte-cryopreservation-for-cancer-patients-prior-to-high-and-low-risk-gonadotoxic-chemotherapy
#1
B Lyttle Schumacher, N Grover, T Mesen, A Steiner, J Mersereau
STUDY QUESTION: What is the live-birth rate (LBR) and cost-effectiveness of fertility preservation with oocyte cryopreservation (FP-OC) compared to expectant management in cancer patients age 25-40 based on estimated gonadotoxicity of treatments 5 years after cancer diagnosis? SUMMARY ANSWER: Oocyte cryopreservation prior to cancer treatment is more costly, yet more effective (producing more live births), than not undergoing oocyte cryopreservation but it is most beneficial for patients undergoing high-risk chemotherapy (HRC)...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28935887/bitter-or-not-bitterpredict-a-tool-for-predicting-taste-from-chemical-structure
#2
Ayana Dagan-Wiener, Ido Nissim, Natalie Ben Abu, Gigliola Borgonovo, Angela Bassoli, Masha Y Niv
Bitter taste is an innately aversive taste modality that is considered to protect animals from consuming toxic compounds. Yet, bitterness is not always noxious and some bitter compounds have beneficial effects on health. Hundreds of bitter compounds were reported (and are accessible via the BitterDB http://bitterdb.agri.huji.ac.il/dbbitter.php ), but numerous additional bitter molecules are still unknown. The dramatic chemical diversity of bitterants makes bitterness prediction a difficult task. Here we present a machine learning classifier, BitterPredict, which predicts whether a compound is bitter or not, based on its chemical structure...
September 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28934514/new-bioinformatics-based-discrimination-formulas-for-differentiation-of-thalassemia-traits-from-iron-deficiency-anemia
#3
Abdul Hafeez Kandhro, Watshara Shoombuatong, Virapong Prachayasittikul, Pornlada Nuchnoi
Thalassemia traits (TTs) and iron deficiency anemia (IDA) are the most common disorders of hypochromic microcytic anemia (HMA). The present study aimed to differentiate TTs from IDA by analyzing discrimination formulas and provides comprehensive data of hemoglobin disorders prevalent in Pakistan. Among 12 published discrimination formulas, 6 formulas-MI, EF, G&K, RDWI, R, and HHI-were the most reliable to discriminate TTs from IDA. The failure cutoff values were improved by the random forest (RF) decision-tree approach...
August 1, 2017: Laboratory Medicine
https://www.readbyqxmd.com/read/28933707/high-accuracy-automatic-classification-of-parkinsonian-tremor-severity-using-machine-learning-method
#4
Hyoseon Jeon, Woongwoo Lee, Hyeyoung Park, Hong Ji Lee, Sang Kyong Kim, Han Byul Kim, Beomseok Jeon, Kwang Suk Park
Although clinical aspirations for new technology to accurately measure and diagnose Parkinsonian tremors exist, automatic scoring of tremor severity using machine learning approaches has not yet been employed. Objective: This study aims to maximize the scientific validity of automatic tremor-severity classification using machine learning algorithms to score Parkinsonian tremor severity in the same manner as the Unified Parkinson's Disease Rating Scale (UPDRS) used to rate scores in real clinical practice...
September 21, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28933266/intravenous-paracetamol-dosing-guidelines-for-pain-management-in-pre-term-neonates-using-the-paediatric-study-decision-tree
#5
P Mian, C A J Knibbe, E A M Calvier, D Tibboel, K Allegaert
BACKGROUND: Intravenous paracetamol (acetaminophen) has not been licensed for analgesia in preterm neonates or infants < 2 years, respectively, in Europe and the United States. A variety of dosing regimens is therefore used off-label. Because evidence supports the use of the same target mean steady state paracetamol concentration (Cssmean, 9-11 mg/L) for pain relief in neonates compared to older children and adults, dosing regimens based on this Cssmean were evaluated in a two-step approach...
September 21, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28930809/survival-benefit-of-adjuvant-radiotherapy-an-analysis-of-low-stage-invasive-ovarian-mucinous-carcinomas
#6
Aalok Kumar, Nhu Le, C Blake Gilks, Jennifer L Santos, Frances Wong, Kenneth Swenerton, Paul J Hoskins, Jessica N McAlpine, Anna V Tinker
OBJECTIVE: Our aim was to evaluate the population-based outcomes of stages I and II invasive ovarian mucinous carcinomas (MCs) treated with adjuvant platinum-based chemotherapy and abdominopelvic radiotherapy (XRT). METHODS: International Federation of Gynecology and Obstetrics stage I/II MC cases referred to the British Columbia Cancer Agency between 1984 and 2014 were reviewed. Chemotherapy (minimum of 3 cycles) and XRT were the institutional policy for stages IA/B (grade 2/3) and IC/II (any grade)...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28927668/societal-costs-in-displaced-transverse-olecranon-fractures-using-decision-analysis-tools-to-find-the-most-cost-effective-strategy-between-tension-band-wiring-and-locked-plating
#7
Tittu Francis, Travis Washington, Karan Srivastava, Vasilios Moutzouros, Eric C Makhni, William Hakeos
BACKGROUND: Tension band wiring (TBW) and locked plating are common treatment options for Mayo IIA olecranon fractures. Clinical trials have shown excellent functional outcomes with both techniques. Although TBW implants are significantly less expensive than a locked olecranon plate, TBW often requires an additional operation for implant removal. To choose the most cost-effective treatment strategy, surgeons must understand how implant costs and return to the operating room influence the most cost-effective strategy...
September 15, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28926750/land-cover-and-air-pollution-are-associated-with-asthma-hospitalisations-a-cross-sectional-study
#8
Ian Alcock, Mathew White, Mark Cherrie, Benedict Wheeler, Jonathon Taylor, Rachel McInnes, Eveline Otte Im Kampe, Sotiris Vardoulakis, Christophe Sarran, Ireneous Soyiri, Lora Fleming
BACKGROUND: There is increasing policy interest in the potential for vegetation in urban areas to mitigate harmful effects of air pollution on respiratory health. We aimed to quantify relationships between tree and green space density and asthma-related hospitalisations, and explore how these varied with exposure to background air pollution concentrations. METHODS: Population standardised asthma hospitalisation rates (1997-2012) for 26,455 urban residential areas of England were merged with area-level data on vegetation and background air pollutant concentrations...
September 16, 2017: Environment International
https://www.readbyqxmd.com/read/28922931/an-exploratory-decision-tree-analysis-to-predict-physical-activity-compliance-rates-in-breast-cancer-survivors
#9
Raheem J Paxton, Lingfeng Zhang, Changshuai Wei, Daniel Price, Fan Zhang, Kerry S Courneya, Ioannis A Kakadiaris
BACKGROUND: The study of physical activity in cancer survivors has been limited to one cause, one effect relationships. In this exploratory study, we used recursive partitioning to examine multiple correlates that influence physical activity compliance rates in cancer survivors. METHODS: African American breast cancer survivors (N = 267, Mean age = 54 years) participated in an online survey that examined correlates of physical activity. Recursive partitioning (RP) was used to examine complex and nonlinear associations between sociodemographic, medical, cancer-related, theoretical, and quality of life indicators...
September 19, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28921765/assessing-fire-impacts-on-the-carbon-stability-of-fire-tolerant-forests
#10
Lauren T Bennett, Matthew J Bruce, Josephine Machunter, Michele Kohout, Saravanan Jangammanaidu Krishnaraj, Cristina Aponte
The carbon stability of fire-tolerant forests is often assumed but less frequently assessed, limiting potential to anticipate threats to forest carbon posed by predicted increases in forest fire activity. Assessing the carbon stability of fire-tolerant forests requires multi-indicator approaches that recognise the myriad of ways that fires influence the carbon balance including combustion, deposition of pyrogenic material, and tree death, post-fire decomposition, recruitment, and growth. Five years after a large-scale wildfire in south-eastern Australia, we assessed the impacts of low- and high-severity wildfire, with and without prescribed fire (≤ 10 years before), on carbon stocks in multiple pools, and on carbon stability indicators (carbon stock percentages in live trees and in small trees, and carbon stocks in char and fuels) in fire-tolerant eucalypt forests...
September 16, 2017: Ecological Applications: a Publication of the Ecological Society of America
https://www.readbyqxmd.com/read/28918607/modeling-the-ph-and-temperature-dependence-of-aqueousphase-hydroxyl-radical-reaction-rate-constants-of-organic-micropollutants-using-qspr-approach
#11
Shikha Gupta, Nikita Basant
Designing of advanced oxidation process (AOP) requires knowledge of the aqueous phase hydroxyl radical ((●)OH) reactions rate constants (k OH), which are strictly dependent upon the pH and temperature of the medium. In this study, pH- and temperature-dependent quantitative structure-property relationship (QSPR) models based on the decision tree boost (DTB) approach were developed for the prediction of k OH of diverse organic contaminants following the OECD guidelines. Experimental datasets (n = 958) pertaining to the k OH values of aqueous phase reactions at different pH (n = 470; 1...
September 16, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28918577/microarray-based-snp-genotyping-to-identify-genetic-risk-factors-of-triple-negative-breast-cancer-tnbc-in-south-indian-population
#12
M Aravind Kumar, Vineeta Singh, Shaik Mohammad Naushad, Uday Shanker, M Lakshmi Narasu
In the view of aggressive nature of Triple-Negative Breast cancer (TNBC) due to the lack of receptors (ER, PR, HER2) and high incidence of drug resistance associated with it, a case-control association study was conducted to identify the contributing genetic risk factors for Triple-negative breast cancer (TNBC). A total of 30 TNBC patients and 50 age and gender-matched controls of Indian origin were screened for 9,00,000 SNP markers using microarray-based SNP genotyping approach. The initial PLINK association analysis (p < 0...
September 16, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28916935/risk-stratification-model-lower-extremity-ultrasonography-for-hospitalized-patients-with-suspected-deep-vein-thrombosis
#13
Emily C Alper, Ivan K Ip, Patricia Balthazar, Gregory Piazza, Samuel Z Goldhaber, Carol B Benson, Ronilda Lacson, Ramin Khorasani
BACKGROUND: The Wells score for deep venous thrombosis (DVT) has a high failure rate and low efficiency among inpatients. OBJECTIVE: To create and validate an inpatient-specific risk stratification model to help assess pre-test probability of DVT in hospitalized patients. DESIGN: Prospective cohort study of hospitalized patients undergoing lower-extremity ultrasonography studies (LEUS) for suspected DVT. Demographics, physical findings, medical history, medications, hospitalization, and laboratory and imaging results were collected...
September 15, 2017: Journal of General Internal Medicine
https://www.readbyqxmd.com/read/28916602/validation-study-of-image-based-fractional-flow-reserve-during-coronary-angiography
#14
Mariano Pellicano, Ifat Lavi, Bernard De Bruyne, Hana Vaknin-Assa, Abid Assali, Orna Valtzer, Yonit Lotringer, Giora Weisz, Yaron Almagor, Panagiotis Xaplanteris, Ajay J Kirtane, Pablo Codner, Martin B Leon, Ran Kornowski
BACKGROUND: Fractional flow reserve (FFR), an index of the hemodynamic severity of coronary stenoses, is derived from invasive measurements and requires a pressure-monitoring guidewire and hyperemic stimulus. Angiography-derived FFR measurements (FFRangio) may have several advantages. The aim of this study is to assess the diagnostic performance and interobserver reproducibility of FFRangio in patients with stable coronary artery disease. METHODS AND RESULTS: FFRangio is a computational method based on rapid flow analysis for the assessment of FFR...
September 2017: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28915459/relationships-of-co2-assimilation-rates-with-exposure-and-flux-based-o3-metrics-in-three-urban-tree-species
#15
Yansen Xu, Bo Shang, Xiangyang Yuan, Zhaozhong Feng, Vicent Calatayud
The relationships of CO2 assimilation under saturated-light conditions (Asat) with exposure- (AOTX, Accumulated Ozone exposure over a hourly Threshold of X ppb) and flux-based (PODY, Phytotoxic Ozone Dose over a hourly threshold Y nmol·m(-2)·s(-1)) O3 metrics was studied on three common urban trees, Fraxinus chinensis (FC), Platanus orientalis (PO) and Robinia pseudoacacia (RP). Parameterizations for a stomatal multiplicative model were proposed for the three species. RP was the species showing lower species-specific maximum stomatal conductance (gmax) and experiencing lower cumulative O3 uptake along the experiment, but in contrast it was the most sensitive to O3...
September 12, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28913614/researchers-must-be-aware-of-their-roles-at-the-interface-of-ecosystem-services-science-and-policy
#16
Emilie Crouzat, Isabelle Arpin, Lucas Brunet, Matthew J Colloff, Francis Turkelboom, Sandra Lavorel
Scientists working on ecosystem service (ES) science are engaged in a mission-driven discipline. They can contribute to science-policy interfaces where knowledge is co-produced and used. How scientists engage with the governance arena to mobilise their knowledge remains a matter of personal choice, influenced by individual values. ES science cannot be considered neutral and a discussion of the values that shape it forms an important part of the sustainability dialogue. We propose a simple decision tree to help ES scientists identify their role and the purpose of the knowledge they produce...
September 14, 2017: Ambio
https://www.readbyqxmd.com/read/28911750/effect-of-counselling-on-health-care-seeking-behaviours-and-rabies-vaccination-adherence-after-dog-bites-in-haiti-2014-15-a-retrospective-follow-up-survey
#17
Melissa Dominique Etheart, Maxwell Kligerman, Pierre Dilius Augustin, Jesse D Blanton, Benjamin Monroe, Ludder Fleurinord, Max Millien, Kelly Crowdis, Natael Fenelon, Ryan MacLaren Wallace
BACKGROUND: Haiti has an integrated bite case management (IBCM) programme to counsel animal-bite victims on the risk of rabies and appropriate treatment, as well as the Haiti Animal Rabies Surveillance Program (HARSP) to examine the animals. We assessed the usefulness of the IBCM programme to promote best practices for rabies prophylaxis after exposure in a low-income rabies-endemic setting. METHODS: We did a retrospective follow-up survey of randomly selected bite victims who were counselled by Haiti's IBCM programme between May 15, 2014, and Sept 15, 2015...
October 2017: Lancet Global Health
https://www.readbyqxmd.com/read/28906190/exploring-factors-associated-with-pressure-ulcers-in-long-term-care-facilities-using-decision-tree-analysis-use-of-the-health-insurance-review-and-assessment-service-national-inpatient-sample
#18
Mikyung Moon, Soo-Kyoung Lee
No abstract text is available yet for this article.
October 2017: Western Journal of Nursing Research
https://www.readbyqxmd.com/read/28902106/fine-tuning-the-predictive-model-for-proximal-junctional-failure-in-surgically-treated-patients-with-adult-spinal-deformity
#19
Mitsuru Yagi, Nobuyuki Fujita, Eijiro Okada, Osahiko Tsuji, Narihito Nagoshi, Takashi Asazuma, Ken Ishii, Masaya Nakamura, Morio Matsumoto, Kota Watanabe
STUDY DESIGN: Multi-center retrospective study. OBJECTIVE: To validate and improve the predictive model for proximal junctional failure (PJF) with or without the bone mineral density (BMD) score. SUMMARY OF BACKGROUND DATA: PJF is a serious complication of surgery for adult spinal deformity (ADS). A predictive model for PJF was recently reported that has good accuracy, but does not include BMD, a known PJF risk factor, as a variable. METHODS: We included 145 surgically treated ASD patients who were older than 50 at the time of surgery and had been followed up for at least 2 years...
September 8, 2017: Spine
https://www.readbyqxmd.com/read/28895089/bilateral-salpingo-oophorectomy-versus-gnrh-analogue-in-the-adjuvant-treatment-of-premenopausal-breast-cancer-patients-cost-effectiveness-evaluation-of-breast-cancer-outcome-ovarian-cancer-prevention-and-treatment
#20
Gabriella Ferrandina, Giulia Amadio, Andrea Marcellusi, Elena Azzolini, Anna Puggina, Roberta Pastorino, Walter Ricciardi, Giovanni Scambia
BACKGROUND AND OBJECTIVE: There is no available evidence to recommend gonadotropin-releasing hormone (GnRH) analogue-based ovarian suppression versus bilateral salpingo-oophorectomy (BSO) in the adjuvant treatment of early breast cancer, since the two approaches are considered equivalent in terms of oncologic outcome. The role of surgical ovarian ablation has been revitalized based on the advances of minimally invasive surgery, and a better understanding of clinical and molecular basis of hereditary breast/ovarian cancer syndromes...
September 11, 2017: Clinical Drug Investigation
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