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https://www.readbyqxmd.com/read/29785060/cost-effectiveness-of-vitamin-c-supplementation-for-pregnant-smokers-to-improve-offspring-lung-function-at-birth-and-reduce-childhood-wheeze-asthma
#1
Leah Yieh, Cindy T McEvoy, Scott W Hoffman, Aaron B Caughey, Kelvin D MacDonald, Dmitry Dukhovny
OBJECTIVE: To determine the implications of supplemental vitamin C for pregnant tobacco smokers and its effects on the prevalence of pediatric asthma, asthma-related mortality, and associated costs. STUDY DESIGN: A decision-analytic model built via TreeAge compared the outcome of asthma in a theoretical annual cohort of 480,000 children born to pregnant smokers through 18 years of life. Vitamin C supplementation (500 mg/day) with a standard prenatal vitamin was compared to a prenatal vitamin (60 mg/day)...
May 22, 2018: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29757360/decision-analysis-supports-the-use-of-drain-amylase-based-enhanced-recovery-method-after-esophagectomy
#2
B Jiang, V P Ho, J Ginsberg, S J Fu, Y Perry, L Argote-Greene, P A Linden, C W Towe
Postesophagectomy anastomotic leak is a common postsurgical complication. The current standard method of detecting leak is esophagram usually late in the postoperative period. Perianastomotic drain amylase level had shown promising results in early detection anastomosis leak. Previous studies have shown that postoperative day 4 amylase level is more specific and sensitive than esophagram. The purpose of this study is to determine if implementing a drain amylase-based screening method for anastomotic leak can reduce length of stay and hospital cost relative to a traditional esophagram-based pathway...
May 10, 2018: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/29734231/cost-effectiveness-analysis-of-routine-venous-doppler-ultrasound-for-diagnosis-of-deep-venous-thrombosis-at-admission-to-inpatient-rehabilitation
#3
Shanti M Pinto, Mohamed Yassin, Gary Galang
OBJECTIVE: 1. Identify whether timing of venous thromboembolism (VTE) diagnosis is associated with differences in patient outcomes. 2. Perform a cost-effectiveness analysis of routine venous Doppler ultrasound at admission to inpatient rehabilitation (IPR), taking into account costs associated with prolonged IPR length of stay (LOS) and development of pulmonary embolism (PE). DESIGN: This was a retrospective cohort study of 2312 consecutive patient discharges from a single IPR facility over an 18-month period...
May 4, 2018: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/29577766/cost-of-prescription-drug-related-morbidity-and-mortality
#4
Jonathan H Watanabe, Terry McInnis, Jan D Hirsch
BACKGROUND: Public attention and recent US Congressional activity has intensified focus on escalating medication prices. However, the actual cost of medication use extends beyond the up-front cost of purchasing medicines. It also encompasses the additional medical costs of morbidity and mortality resulting from nonoptimized medication regimens, including medication nonadherence. OBJECTIVES: Applying the most current nationally representative data sources, our goal was to estimate the cost of prescription drug-related morbidity and mortality in the United States...
March 1, 2018: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29519780/robotic-versus-open-renal-transplantation-in-obese-patients-protocol-for-a-cost-benefit-markov-model-analysis
#5
Michele Molinari, Chethan Puttarajappa, Martin Wijkstrom, Armando Ganoza, Roberto Lopez, Amit Tevar
BACKGROUND: Recent studies have reported a significant decrease in wound problems and hospital stay in obese patients undergoing renal transplantation by robotic-assisted minimally invasive techniques with no difference in graft function. OBJECTIVE: Due to the lack of cost-benefit studies on the use of robotic-assisted renal transplantation versus open surgical procedure, the primary aim of our study is to develop a Markov model to analyze the cost-benefit of robotic surgery versus open traditional surgery in obese patients in need of a renal transplant...
March 8, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29420402/twenty-week-abortion-bans-on-pregnancies-with-a-congenital-diaphragmatic-hernia-a-cost-effectiveness-analysis
#6
Kimberley A Bullard, Brian L Shaffer, Karen S Greiner, Ashley E Skeith, Maria I Rodriguez, Aaron B Caughey
OBJECTIVE: To estimate the effect of 20-week abortion bans on maternal and consequent neonatal health outcomes and costs in the setting of fetal congenital diaphragmatic hernia. METHODS: A decision-analytic model was built using TreeAge software to evaluate the effect of a 20-week ban on abortion in a theoretical cohort of 921 women diagnosed with fetal congenital diaphragmatic hernia. Probabilities, utilities, and costs were derived from the literature. The cohort size was based on the annual rate of prenatal diagnoses of congenital diaphragmatic hernia and live births among the 20 states with bans...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29374511/amiodarone-protocol-provides-cost-effective-reduction-in-postoperative-atrial-fibrillation
#7
J Hunter Mehaffey, Robert B Hawkins, Matthew Byler, Judy Smith, John A Kern, Irving Kron, Gorav Ailawadi, Tanya Wanchek, Leora T Yarboro
BACKGROUND: Postoperative Atrial Fibrillation (POAF) following cardiac surgery results in a significant increase in morbidity, mortality, and healthcare cost. Prophylactic amiodarone has been shown to reduce the incidence of POAF, however the cost-effectiveness of a protocol driven approach remains unknown. METHODS: All patients with a Society of Thoracic Surgeons (STS) risk score enrolled in a prophylactic amiodarone protocol (n=153) were propensity score matched 1:3 with patients prior to protocol implementation (n=3574)...
January 24, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29299210/cost-effectiveness-of-methadone-maintenance-treatment-centers-in-prevention-of-human-immunodeficiency-virus-infection
#8
Sirus Pourkhajoei, Mohsen Barouni, Alireza Noroozi, Ahmad Hajebi, Saeed Amini, Mohammad Karamouzian, Hamid Sharifi
Background: Acquired immune deficiency syndrome (AIDS) is one of the greatest social health problems in many communities in the twenty-first century. Methadone maintenance treatment (MMT) could decrease HIV infection among injection drug users (IDU). The main aim of this paper was to determine the cost-effectiveness of the governmental MMT program to prevent human immunodeficiency virus (HIV) infection among IDU. Methods: This analytical study was performed through a before-after assessment during a one-year period...
April 2017: Addiction & Health
https://www.readbyqxmd.com/read/29289729/replacing-amalgam-with-a-high-viscosity-glass-ionomer-in-restoring-primary-teeth-a-cost-effectiveness-study-in-brasilia-brazil
#9
A Goldman, J E Frencken, R G De Amorim, S C Leal
OBJECTIVES: When planning primary oral health care services the cost implications of adopting new intervention practices are important, especially in resource-strapped countries. Although on a trajectory to be phased-out, amalgam remains the standard of care in many countries. METHODS: Adopting a government perspective, this study compared the costs of performing amalgam and ART/high-viscosity glass-ionomer cement (HVGIC) restorations and the consequences of failed restorations over 3 years in suburban Brasilia, Brazil...
March 2018: Journal of Dentistry
https://www.readbyqxmd.com/read/29203507/the-short-term-health-and-economic-burden-of-gestational-diabetes-mellitus-in-china-a-modelling-study
#10
Tingting Xu, Livia Dainelli, Kai Yu, Liangkun Ma, Irma Silva Zolezzi, Patrick Detzel, Hai Fang
OBJECTIVES: Gestational diabetes mellitus (GDM) is associated with a higher risk for adverse health outcomes during pregnancy and delivery for both mothers and babies. This study aims to assess the short-term health and economic burden of GDM in China in 2015. DESIGN: Using TreeAge Pro, an analytical decision model was built to estimate the incremental costs and quality-of-life loss due to GDM, in comparison with pregnancy without GDM from the 28th gestational week until and including childbirth...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29157136/blood-transfusion-versus-hydroxyurea-in-beta-thalassemia-in-iran-a-cost-effectiveness-study
#11
Ramin Ravangard, Zahra Mirzaei, Khosro Keshavarz, Sezaneh Haghpanah, Mehran Karimi
INTRODUCTION: Thalassemia intermedia is a type of anemia which has several treatments modalities. We aimed to study the cost effectiveness of two treatments, including blood transfusion and hydroxyurea, in patients with beta-thalassemia intermedia in south of Iran referred to a referral center affiliated to Iran, Shiraz University of Medical Sciences in 2015. MATERIALS AND METHODS: This was a cost-effectiveness study which was conducted on 122 patients with beta-thalassemia intermedia...
November 21, 2017: Hematology (Amsterdam, Netherlands)
https://www.readbyqxmd.com/read/29112658/adding-azithromycin-to-cephalosporin-for-cesarean-delivery-infection-prophylaxis-a-cost-effectiveness-analysis
#12
Ashley E Skeith, Brenda Niu, Amy M Valent, Methodius G Tuuli, Aaron B Caughey
OBJECTIVE: To investigate the cost-effectiveness of adding azithromycin to standard cephalosporin regimens of cesarean delivery prophylaxis by considering the maternal outcomes in the current and potential subsequent pregnancies. METHODS: A cost-effectiveness model was created using TreeAge to compare the outcomes of using azithromycin-cephalosporin with cephalosporin alone in a theoretical cohort of 700,000 women, the approximate number of nonelective cesarean deliveries annually in the United States that occur during labor or after membrane rupture...
December 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29105528/cost-effectiveness-analysis-of-tissue-plasminogen-activator-in-acute-ischemic-stroke-in-iran
#13
Asrin Amiri, Reza Goudarzi, Mohammadreza Amiresmaili, Farhad Iranmanesh
AIMS: Tissue plasminogen activator (tPA) is used to treat acute ischemic stroke up to 4.5 h after symptom onset. Its cost-effectiveness in developing countries is not specified yet. This study aimed to study cost-effectiveness of tPA in Iran. METHODS: This is a cost-effectiveness analysis from the perspective of the third party payer to compare IV tPA with no tPA of ischemic stroke. A Markov model with a lifetime horizon was used to analyze the costs and outcomes...
March 2018: Journal of Medical Economics
https://www.readbyqxmd.com/read/29076745/cost-effectiveness-of-magnetic-resonance-carotid-plaque-imaging-for-primary-stroke-prevention-in-canada
#14
Lechtman E, Balki I, Thomas K, Chen K, Moody Ar, Tyrrell Pn
OBJECTIVE: Magnetic resonance of the carotid arteries provides important insight into plaque composition and vulnerability in addition to the traditional measure of stenosis. The purpose of this study was to evaluate the cost-effectiveness of MR imaging as a first-line modality to assess carotid disease and guide management for high-risk patients with <50% stenosis. METHODS: Using TreeAge Pro, a cost-effectiveness simulation was conducted comparing two strategies: (a) standard of care first-line carotid duplex ultrasound (DUS) with regular follow-up, vs (b) first-line MR assessment of stenosis and intraplaque haemorrhage (MRIPH) in which patients with IPH received annual DUS surveillance and immediate carotid endarterectomy in case of plaque progression...
January 2018: British Journal of Radiology
https://www.readbyqxmd.com/read/29048918/cost-effectiveness-of-screening-colonoscopy-in-iranian-high-risk-population
#15
Hamideh Javadinasab, Rajabali Daroudi, Hamideh Salimzadeh, Alireza Delavari, Payam Vezvaie, Reza Malekzadeh
BACKGROUND: Colorectal cancer (CRC) is the fourth most common cancer among men and the second among women in Iran. First-Degree Relatives (FDRs) of patients with CRC are known to be at higher risk of CRC. The aim of this study was to identify the most cost-effective strategy for CRC screening in Iranian high risk individuals. METHODS: A Markov model was developed to assess the cost-effectiveness of six colonoscopy screening strategies for individuals at increased risk of CRC because of positive history of the disease in at least one first-degree relative in their family...
September 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/29041915/cost-effectiveness-analysis-of-xelox-versus-xelox-plus-bevacizumab-for-metastatic-colorectal-cancer-in-a-public-hospital-school
#16
Andrea Queiróz Ungari, Leonardo Régis Leira Pereira, Altacílio Aparecido Nunes, Fernanda Maris Peria
BACKGROUND: Metastatic colorectal cancer imposes a substantial burden on patients and society. Over the last years, progresses in the treatment have been made especially due to the introduction of monoclonal antibodies, such as bevacizumab which, on the other hand, has considerably increased the costs of treatment. We performed a cost-effectiveness analysis of bevacizumab plus XELOX in comparison with XELOX alone in metastatic colorectal cancer in first-line therapy, from the perspective of a public hospital school in Brazil...
October 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/29039025/cost-effectiveness-analysis-of-contralateral-prophylactic-mastectomy-compared-to-unilateral-mastectomy-with-routine-surveillance-for-unilateral-sporadic-breast-cancer
#17
Robert C Keskey, A Scott LaJoie, Brad S Sutton, In K Kim, William G Cheadle, Kelly M McMasters, Nicolas Ajkay
BACKGROUND: Contralateral prophylactic mastectomy (CPM) rates in younger women with unilateral breast cancer have more than doubled. Studies of cost and quality of life of the procedure remain inconclusive. METHODS: A cost-effectiveness analysis using a decision-tree model in TreeAge Pro 2015 was used to compare long-term costs and quality of life following unilateral mastectomy (UM) with routine surveillance versus CPM for sporadic breast cancer in women aged 45 years...
October 16, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28938728/modeling-of-live-birth-rates-and-cost-effectiveness-of-oocyte-cryopreservation-for-cancer-patients-prior-to-high-and-low-risk-gonadotoxic-chemotherapy
#18
B Lyttle Schumacher, N Grover, T Mesen, A Steiner, J Mersereau
STUDY QUESTION: What is the live-birth rate (LBR) and cost-effectiveness of fertility preservation with oocyte cryopreservation (FP-OC) compared to expectant management in cancer patients age 25-40 based on estimated gonadotoxicity of treatments 5 years after cancer diagnosis? SUMMARY ANSWER: Oocyte cryopreservation prior to cancer treatment is more costly, yet more effective (producing more live births), than not undergoing oocyte cryopreservation but it is most beneficial for patients undergoing high-risk chemotherapy (HRC)...
October 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28819067/health-economics-of-targeted-intraoperative-radiotherapy-targit-iort-for-early-breast-cancer-a-cost-effectiveness-analysis-in-the-united-kingdom
#19
Anil Vaidya, Param Vaidya, Brigitte Both, Chris Brew-Graves, Max Bulsara, Jayant S Vaidya
OBJECTIVE: The clinical effectiveness of targeted intraoperative radiotherapy (TARGIT-IORT) has been confirmed in the randomised TARGIT-A (targeted intraoperative radiotherapy-alone) trial to be similar to a several weeks' course of whole-breast external-beam radiation therapy (EBRT) in patients with early breast cancer. This study aims to determine the cost-effectiveness of TARGIT-IORT to inform policy decisions about its wider implementation. SETTING: TARGIT-A randomised clinical trial (ISRCTN34086741) which compared TARGIT with traditional EBRT and found similar breast cancer control, particularly when TARGIT was given simultaneously with lumpectomy...
August 17, 2017: BMJ Open
https://www.readbyqxmd.com/read/28738454/-development-of-markov-models-for-economics-evaluation-of-strategies-on-hepatitis-b-vaccination-and-population-based-antiviral-treatment-in-china
#20
P C Yang, S X Zhang, P P Sun, Y L Cai, Y Lin, Y H Zou
Objective: To construct the Markov models to reflect the reality of prevention and treatment interventions against hepatitis B virus (HBV) infection, simulate the natural history of HBV infection in different age groups and provide evidence for the economics evaluations of hepatitis B vaccination and population-based antiviral treatment in China. Methods: According to the theory and techniques of Markov chain, the Markov models of Chinese HBV epidemic were developed based on the national data and related literature both at home and abroad, including the settings of Markov model states, allowable transitions and initial and transition probabilities...
July 10, 2017: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
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