keyword
https://read.qxmd.com/read/38539317/the-associations-between-lifestyle-habits-and-anxiety-a-prospective-study-on-adolescents-one-year-after-the-outbreak-of-the-covid-19-pandemic
#1
JOURNAL ARTICLE
Laura Pedrini, Serena Meloni, Julia Dawson, Andrea Geviti, Natale Salvatore Bonfiglio, Anna Cattaneo, Roberta Rossi
Changes in lifestyle during the pandemic may have predisposed adolescents to vulnerability to poor mental health. This study aims to evaluate these changes and their association with the course of anxiety. A prospective study was conducted with 153 participants (16 years old, 72% female) who were assessed before the pandemic (T0, November 2019-January 2020) and one year later (T1, April-May 2021). Lifestyle habits (free-time activities, maladaptive behaviors, sleep, screen use) and anxiety were measured. Data concerning experiences related to COVID-19 and family relations during lockdown were collected...
February 25, 2024: Children
https://read.qxmd.com/read/38484217/membrane-proteome-wide-screening-of-autoantibodies-in-cidp-using-human-cell-microarray-technology
#2
JOURNAL ARTICLE
Marta Caballero-Ávila, Cinta Lleixà, Elba Pascual-Goñi, Lorena Martín-Aguilar, Núria Vidal-Fernandez, Clara Tejada-Illa, Roger Collet-Vidiella, Ricardo Rojas-Garcia, Elena Cortés-Vicente, Janina Turon-Sans, Eduard Gallardo, Montse Olivé, Ana Vesperinas, Álvaro Carbayo, Laura Llansó, Laura Martinez-Martinez, Anthony Shock, Louis Christodoulou, Benjamin Dizier, Jim Freeth, Jo Soden, Sarah Dawson, Luis Querol
BACKGROUND AND OBJECTIVES: Autoantibody discovery in complex autoimmune diseases is challenging. Diverse successful antigen identification strategies are available, but, so far, have often been unsuccessful, especially in the discovery of protein antigens in which conformational and post-translational modification are critical. Our study assesses the utility of a human membrane and secreted protein microarray technology to detect autoantibodies in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)...
May 2024: Neurology® Neuroimmunology & Neuroinflammation
https://read.qxmd.com/read/38445180/prospective-evaluation-of-patient-reported-anxiety-and-experiences-with-adaptive-radiation-therapy-on-an-mr-linac
#3
JOURNAL ARTICLE
Amanda Moreira, Winnie Li, Alejandro Berlin, Cathy Carpino-Rocca, Peter Chung, Leigh Conroy, Jennifer Dang, Laura A Dawson, Rachel M Glicksman, Ali Hosni, Harald Keller, Vickie Kong, Patricia Lindsay, Andrea Shessel, Teo Stanescu, Edward Taylor, Jeff Winter, Michael Yan, Daniel Letourneau, Michael Milosevic, Michael Velec
PURPOSE: An integrated magnetic resonance scanner and linear accelerator (MR-linac) was implemented with daily online adaptive radiation therapy (ART). This study evaluated patient-reported experiences with their overall hospital care as well as treatment in the MR-linac environment. METHODS: Patients pre-screened for MR eligibility and claustrophobia were referred to simulation on a 1.5 T MR-linac. Patient-reported experience measures were captured using two validated surveys...
March 2024: Technical innovations & patient support in radiation oncology
https://read.qxmd.com/read/38425310/the-characteristics-and-predictors-of-mortality-in-periprosthetic-fractures-around-the-knee
#4
MULTICENTER STUDY
Ahmed A H H Nasser, Manpreet Sidhu, Rohan Prakash, Ansar Mahmood, Khabab Osman, Govind S Chauhan, Rajpal Nandra, Varun Dewan, Jerome Davidson, Mohammed Al-Azzawi, Christian Smith, Mothana Gawad, Ioannis Palaiologos, Rory Cuthbert, Warran Wignadasan, Daniel Banks, James Archer, Abdulrahman Odeh, Thomas Moores, Muaaz Tahir, Margaret Brooks, Gurdeep Biring, Stevan Jordan, Zain Elahi, Mohammed Shaath, Manoj Veettil, Chiranjit De, Charles Handford, Mohit Bansal, Akshdeep Bawa, Ahmed Mattar, Varun Tandra, Audrina Daadipour, Ahmed Taha, Shafat Gangoo, Sriram Srinivasan, Mandishona Tarisai, Basil Budair, Krishna Subbaraman, Farrukh Khan, Austin Gomindes, Arjun Samuel, Niel Kang, Karan Kapur, Elizabeth Mainwaring, Hannah Bridgwater, Andre Lo, Usman Ahmed, Tahir Khaleeq, Ahmed El-Bakoury, Ramy Rashed, Hazem Hosny, Rathan Yarlagadda, Jonathan Keenan, Ahmed Hamed, Bryan Riemer, Arham Qureshi, Vatsal Gupta, Matthew Waites, Sabri Bleibleh, David Westacott, Jonathan Phillips, Jamie East, Daniel Huntley, Saqib Masud, Yusuf Mirza, Sandeep Mishra, David Dunlop, Mohamed Khalefa, Balasubramanian Balakumar, Mahesh Thibbaiah, Olivia Payton, James Berstock, Krisna Deano, Khaled M Sarraf, Kartik Logishetty, George Lee, Hariharan Subbiah-Ponniah, Nirav Shah, Aakaash Venkatesan, James Cheseldene-Culley, Joseph Ayathamattam, Samantha Tross, Sukhwinder Randhawa, Faisal Mohammed, Ramla Ali, Jonathan Bird, Kursheed Khan, Muhammad A Akhtar, Andrew Brunt, Panagiotis Roupakiotis, Padmanabhan Subramanian, Nelson Bua, Mounir Hakimi, Samer Bitar, Majed Al Najjar, Ajay Radhakrishnan, Charlie Gamble, Andrew James, Catherine Gilmore, Dan Dawson, Rajesh Sofat, Mohamed Antar, Aashish Raghu, Sam Heaton, Waleed Tawfeek, Christerlyn Charles, Henry Burnand, Sean Duffy, Luke Taylor, Laura Magill, Rita Perry, Michala Pettitt, Kelvin Okoth, Thomas Pinkney
AIMS: Periprosthetic fractures (PPFs) around the knee are challenging injuries. This study aims to describe the characteristics of knee PPFs and the impact of patient demographics, fracture types, and management modalities on in-hospital mortality. METHODS: Using a multicentre study design, independent of registry data, we included adult patients sustaining a PPF around a knee arthroplasty between 1 January 2010 and 31 December 2019. Univariate, then multivariable, logistic regression analyses were performed to study the impact of patient, fracture, and treatment on mortality...
February 1, 2024: Bone & Joint Journal
https://read.qxmd.com/read/38380116/do-we-have-a-winner-advocating-for-sbrt-in-hcc-management
#5
JOURNAL ARTICLE
Amir H Safavi, Laura A Dawson, Aruz Mesci
•Stereotactic body radiotherapy (SBRT) is a safe and effective locoregional therapy for inoperable patients with HCC.•SBRT compares favorably with other local therapies in terms of local control, survival, morbidity, and cost-effectiveness.•SBRT should be considered and discussed in multidisciplinary management of appropriate HCC patients.•Advances in SBRT and novel combinations with systemic therapy may further widen the therapeutic index in HCC.
March 2024: Clinical and Translational Radiation Oncology
https://read.qxmd.com/read/38368380/supporting-physical-activity-through-co-production-in-people-with-severe-mental-ill-health-spaces-protocol-for-a-randomised-controlled-feasibility-trial
#6
JOURNAL ARTICLE
Gareth Jones, Laura Bailey, Rebecca J Beeken, Samantha Brady, Cindy Cooper, Robert J Copeland, Suzanne Crosland, Sam Dawson, Matthew Faires, Simon Gilbody, Holly Haynes, Andrew Hill, Emily Hillison, Michelle Horspool, Ellen Lee, Jinshuo Li, Katarzyna K Machaczek, Steve Parrott, Helen Quirk, Brendon Stubbs, Garry A Tew, Gemma Traviss-Turner, Emily Turton, Lauren Walker, Stephen Walters, Scott Weich, Ellie Wildbore, Emily Peckham
BACKGROUND: Severe mental ill health (SMI) includes schizophrenia, bipolar disorder and schizoaffective disorder and is associated with premature deaths when compared to people without SMI. Over 70% of those deaths are attributed to preventable health conditions, which have the potential to be positively affected by the adoption of healthy behaviours, such as physical activity. People with SMI are generally less active than those without and face unique barriers to being physically active...
February 17, 2024: Pilot and Feasibility Studies
https://read.qxmd.com/read/38343868/a-longitudinal-assessment-of-heat-exposure-and-biomarkers-of-kidney-function-on-heat-shock-protein-70-and-antibodies-among-agricultural-workers
#7
Jaime Butler-Dawson, Richard J Johnson, Lyndsay Krisher, Diana Jaramillo, Alex Cruz, Daniel Pilloni, Stephen Brindley, Bernardo Rodriguez-Iturbe, Laura Gabriela Sanchez-Lozada, Miranda Dally, Lee S Newman
Background Exposure to extreme heat impacts millions of people worldwide and outdoor workers are among the populations most affected by high temperatures. Heat stress induces several biological responses in humans, including the production of heat shock proteins (HSP) and antibodies against HSP (anti-HSP) which may play a central role in the body's cellular response to a hot environment. Objective This longitudinal study investigated the impact of high temperatures and humidity on the presence of HSP70 and anti-HSP70 and examined relationships with markers of kidney function in an at-risk workforce under conditions of extreme heat and exertion in Guatemala...
January 24, 2024: Research Square
https://read.qxmd.com/read/38316788/leukaemia-exposure-alters-the-transcriptional-profile-and-function-of-bcr-abl1-negative-macrophages-in-the-bone-marrow-niche
#8
JOURNAL ARTICLE
Amy Dawson, Martha M Zarou, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Ekaterini Himonas, Ya-Ching Hsieh, Isabel van Loon, Giovanny Rodriguez Blanco, Angela Ianniciello, Zsombor Kerekes, Vaidehi Krishnan, Puneet Agarwal, Hassan Almasoudi, Laura McCluskey, Lisa E M Hopcroft, Mary T Scott, Pablo Baquero, Karen Dunn, David Vetrie, Mhairi Copland, Ravi Bhatia, Seth B Coffelt, Ong Sin Tiong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G Vignir Helgason
Macrophages are fundamental cells of the innate immune system that support normal haematopoiesis and play roles in both anti-cancer immunity and tumour progression. Here we use a chimeric mouse model of chronic myeloid leukaemia (CML) and human bone marrow (BM) derived macrophages to study the impact of the dysregulated BM microenvironment on bystander macrophages. Utilising single-cell RNA sequencing (scRNA-seq) of Philadelphia chromosome (Ph) negative macrophages we reveal unique subpopulations of immature macrophages residing in the CML BM microenvironment...
February 5, 2024: Nature Communications
https://read.qxmd.com/read/38316192/common-sense-radiation-oncology-redefining-targets-in-radiotherapy
#9
JOURNAL ARTICLE
Nina N Sanford, Yolande Lievens, Ajay Aggarwal, Timothy P Hanna, Laura A Dawson, Jeffrey White, Bishal Gyawali, Christopher Booth, Fabio Ynoe de Moraes
In 2023, the Common Sense Oncology (CSO) movement was launched with the goal of recalibrating cancer care to focus on outcomes that matter to patients. We extend the three CSO pillars - evidence generation, interpretation and communication - to radiation oncology and advocate for better evidence demonstrating the value of our modality.
April 2024: Radiotherapy and Oncology
https://read.qxmd.com/read/38310262/single-vs-multiple-fraction-non-inferiority-trial-of-stereotactic-ablative-radiotherapy-for-the-comprehensive-treatment-of-oligo-metastases-progression-simplify-sabr-comet
#10
JOURNAL ARTICLE
Robert Olson, Hadassah Abraham, Curtis Leclerc, Alexander Benny, Sarah Baker, Quinn Matthews, Nick Chng, Alanah Bergman, Benjamin Mou, Emma M Dunne, Devin Schellenberg, Will Jiang, Elisa Chan, Siavash Atrchian, Shilo Lefresne, Hannah Carolan, Boris Valev, Scott Tyldesley, Andrew Bang, Tanya Berrang, Haley Clark, Fred Hsu, Alexander V Louie, Andrew Warner, David A Palma, Doris Howell, Aisling Barry, Laura Dawson, Petra Grendarova, Debra Walker, Rishi Sinha, Jillian Tsai, Houda Bahig, Isabelle Thibault, Rashmi Koul, Sashendra Senthi, Iain Phillips, Derek Grose, Paul Kelly, John Armstrong, Ronan McDermott, Candice Johnstone, Srini Vasan, Noel Aherne, Stephen Harrow, Mitchell Liu
BACKGROUND: Radiotherapy delivery regimens can vary between a single fraction (SF) and multiple fractions (MF) given daily for up to several weeks depending on the location of the cancer or metastases. With limited evidence comparing fractionation regimens for oligometastases, there is support to explore toxicity levels to nearby organs at risk as a primary outcome while using SF and MF stereotactic ablative radiotherapy (SABR) as well as explore differences in patient-reported quality of life and experience...
February 3, 2024: BMC Cancer
https://read.qxmd.com/read/38302814/differential-effect-of-patient-and-provider-level-factors-on-patient-satisfaction-scores-in-academic-general-internal-medicine-clinics
#11
JOURNAL ARTICLE
Aprill Z Dawson, Laura Hawks, Rebekah J Walker, Leonard E Egede
OBJECTIVE: Determine whether patient-level or provider-level factors have greater influence on patient satisfaction scores in an academic general internal medicine clinic. METHODS: Two years of data (2017-2019) from the Clinician and Group Consumer Assessment of Healthcare Providers and Systems (CGCAHPS) surveys from ambulatory internal medicine clinic visits in an academic health center located in the Midwest United States were used. Patient satisfaction was measured using the overall provider satisfaction score (0-10), dichotomized with 9-10 defined as satisfactory and 0-8 as unsatisfactory...
February 1, 2024: Journal of General Internal Medicine
https://read.qxmd.com/read/38296295/protocol-for-an-evaluation-of-the-initiation-of-an-integrated-longitudinal-outpatient-care-model-for-severe-chronic-non-communicable-diseases-pen-plus-at-secondary-care-facilities-district-hospitals-in-10-lower-income-countries
#12
JOURNAL ARTICLE
Alma J Adler, Emily B Wroe, Andrea Atzori, Neusa Bay, Wondu Bekele, Victoria M Bhambhani, Remy Bitwayiki Nkwiro, Chantelle Boudreaux, Dawson Calixte, Jonathan Chiwanda Banda, Matthew M Coates, Wubaye Walelgne Dagnaw, Katia Domingues, Laura Drown, Symaque Dusabeyezu, Darius Fenelon, Neil Gupta, Isaac Ssinabulya, Yogesh Jain, Yogeshwar Kalkonde, Innocent Kamali, Catherine Karekezi, Biraj Man Karmacharya, Bhagawan Koirala, Julie Makani, Fabio Manenti, Alexio Mangwiro, Beatriz Manuel, Jones K Masiye, Fastone Mathew Goma, Mary Theodory Mayige, Amy McLaughlin, Emmanuel Mensah, Nicole Mocumbi Salipa, Reuben Mutagaywa, Alvern Mutengerere, Gedeon Ngoga, Marta Patiño, Giovanni Putoto, Todd Ruderman, Devashri Salvi, Santigie Sesay, Fameti Taero, Emílio Tostão, Sterman Toussaint, Gene Bukhman, Ana Olga Mocumbi
INTRODUCTION: The Package of Essential Noncommunicable Disease Interventions-Plus (PEN-Plus) is a strategy decentralising care for severe non-communicable diseases (NCDs) including type 1 diabetes, rheumatic heart disease and sickle cell disease, to increase access to care. In the PEN-Plus model, mid-level clinicians in intermediary facilities in low and lower middle income countries are trained to provide integrated care for conditions where services traditionally were only available at tertiary referral facilities...
January 30, 2024: BMJ Open
https://read.qxmd.com/read/38244026/defining-minimum-treatment-parameters-of-ablative-radiation-therapy-in-patients-with-hepatocellular-carcinoma-an-expert-consensus
#13
JOURNAL ARTICLE
Ted K Yanagihara, Joel E Tepper, Andrew M Moon, Aisling Barry, Meritxell Molla, Jinsil Seong, Ferran Torres, Smith Apisarnthanarax, Michael Buckstein, Higinia Cardenes, Daniel T Chang, Mary Feng, Chandan Guha, Christopher L Hallemeier, Maria A Hawkins, Morten Hoyer, Hiromitsu Iwata, Salma K Jabbour, Lisa Kachnic, Jordan Kharofa, Tae Hyun Kim, Alexander Kirichenko, Eugene J Koay, Hirokazu Makishima, Joel Mases, Jeffrey J Meyer, Pablo Munoz-Schuffenegger, Dawn Owen, Hee Chul Park, Jordi Saez, Nina N Sanford, Marta Scorsetti, Grace L Smith, Jennifer Y Wo, Sang Min Yoon, Theodore S Lawrence, Maria Reig, Laura A Dawson
PURPOSE: External beam radiation therapy (EBRT) is a highly effective treatment in select patients with hepatocellular carcinoma (HCC). However, the Barcelona Clinic Liver Cancer system does not recommend the use of EBRT in HCC due to a lack of sufficient evidence and intends to perform an individual patient level meta-analysis of ablative EBRT in this population. However, there are many types of EBRT described in the literature with no formal definition of what constitutes "ablative...
November 14, 2023: Practical Radiation Oncology
https://read.qxmd.com/read/38196618/rare-disease-gene-association-discovery-from-burden-analysis-of-the-100-000-genomes-project-data
#14
Valentina Cipriani, Letizia Vestito, Emma F Magavern, Julius Ob Jacobsen, Gavin Arno, Elijah R Behr, Katherine A Benson, Marta Bertoli, Detlef Bockenhauer, Michael R Bowl, Kate Burley, Li F Chan, Patrick Chinnery, Peter Conlon, Marcos Costa, Alice E Davidson, Sally J Dawson, Elhussein Elhassan, Sarah E Flanagan, Marta Futema, Daniel P Gale, Sonia García-Ruiz, Cecilia Gonzalez Corcia, Helen R Griffin, Sophie Hambleton, Amy R Hicks, Henry Houlden, Richard S Houlston, Sarah A Howles, Robert Kleta, Iris Lekkerkerker, Siying Lin, Petra Liskova, Hannah Mitchison, Heba Morsy, Andrew D Mumford, William G Newman, Ruxandra Neatu, Edel A O'Toole, Albert Cm Ong, Alistair T Pagnamenta, Shamima Rahman, Neil Rajan, Peter N Robinson, Mina Ryten, Omid Sadeghi-Alavijeh, John A Sayer, Claire L Shovlin, Jenny C Taylor, Omri Teltsh, Ian Tomlinson, Arianna Tucci, Clare Turnbull, Albertien M van Eerde, James S Ware, Laura M Watts, Andrew R Webster, Sarah K Westbury, Sean L Zheng, Mark Caulfield, Damian Smedley
To discover rare disease-gene associations, we developed a gene burden analytical framework and applied it to rare, protein-coding variants from whole genome sequencing of 35,008 cases with rare diseases and their family members recruited to the 100,000 Genomes Project (100KGP). Following in silico triaging of the results, 88 novel associations were identified including 38 with existing experimental evidence. We have published the confirmation of one of these associations, hereditary ataxia with UCHL1 , and independent confirmatory evidence has recently been published for four more...
December 21, 2023: medRxiv
https://read.qxmd.com/read/38123156/the-concise-guide-to-pharmacology-2023-24-transporters
#15
JOURNAL ARTICLE
Stephen P H Alexander, Doriano Fabbro, Eamonn Kelly, Alistair A Mathie, John A Peters, Emma L Veale, Jane F Armstrong, Elena Faccenda, Simon D Harding, Jamie A Davies, Laura Amarosi, Catriona M H Anderson, Philip M Beart, Stefan Broer, Paul A Dawson, Gergely Gyimesi, Bruno Hagenbuch, James R Hammond, Jules C Hancox, Michal Hershfinkel, Ken-Ichi Inui, Yoshikatsu Kanai, Stephan Kemp, Edmund R S Kunji, Gavin Stewart, Sotiria Tavoulari, David T Thwaites, Tiziano Verri
The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and over 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org/), which provides more detailed views of target and ligand properties...
October 2023: British Journal of Pharmacology
https://read.qxmd.com/read/38105091/the-use-of-mr-guided-radiation-therapy-for-liver-cancer
#16
REVIEW
Sabrina Prime, Joshua P Schiff, Ali Hosni, Teodor Stanescu, Laura A Dawson, Lauren E Henke
The role of radiotherapy in the management of primary and metastatic liver malignancies has expanded in recent years due to advances such as IGRT and SBRT. MRI-guided radiotherapy (MRgRT) has arisen as an excellent option for the management of hepatocellular carcinoma, cholangiocarcinoma, and liver metastases due to the ability to combine improved hepatic imaging with conformal treatment planning paradigms like adaptive radiotherapy and advanced motion management techniques. Herein we review the data for MRgRT for liver malignancies, as well as describe workflow and technical considerations for the 2 commercially available MRgRT delivery platforms...
January 2024: Seminars in Radiation Oncology
https://read.qxmd.com/read/38097534/repurposed-drugs-and-their-combinations-prevent-morbidity-inducing-dermonecrosis-caused-by-diverse-cytotoxic-snake-venoms
#17
JOURNAL ARTICLE
Steven R Hall, Sean A Rasmussen, Edouard Crittenden, Charlotte A Dawson, Keirah E Bartlett, Adam P Westhorpe, Laura-Oana Albulescu, Jeroen Kool, José María Gutiérrez, Nicholas R Casewell
Morbidity from snakebite envenoming affects approximately 400,000 people annually. Tissue damage at the bite-site often leaves victims with catastrophic life-long injuries and is largely untreatable by current antivenoms. Repurposed small molecule drugs that inhibit specific snake venom toxins show considerable promise for tackling this neglected tropical disease. Using human skin cell assays as an initial model for snakebite-induced dermonecrosis, we show that the drugs 2,3-dimercapto-1-propanesulfonic acid (DMPS), marimastat, and varespladib, alone or in combination, inhibit the cytotoxicity of a broad range of medically important snake venoms...
December 14, 2023: Nature Communications
https://read.qxmd.com/read/38059331/hpv-negative-head-and-neck-cancers-with-adverse-pathological-features-carry-specific-molecular-changes-that-are-associated-with-survival
#18
JOURNAL ARTICLE
Hugh Andrew Jinwook Kim, Peter Y F Zeng, Matthew Cecchini, Mushfiq Hassan Shaikh, Francisco Laxague, Xiaoxiao Deng, Laura Jarycki, Sarah Elizabeth Belle Ryan, Alice Dawson, Mu Han Liu, David A Palma, Krupal Patel, Neil Mundi, John W Barrett, Joe S Mymryk, Paul C Boutros, Anthony C Nichols
BACKGROUND: Adverse pathological features following surgery in head and neck squamous cell carcinoma (HNSCC) are strongly associated with survival and guide adjuvant therapy. We investigated molecular changes associated with these features. METHODS: We downloaded data from the Cancer Genome Atlas and Cancer Proteome Atlas HNSCC cohorts. We compared tumors positive versus negative for perineural invasion (PNI), lymphovascular invasion (LVI), extracapsular spread (ECS), and positive margins (PSM), with multivariable analysis...
December 7, 2023: Head & Neck
https://read.qxmd.com/read/38046464/the-brain-health-diplomat-s-toolkit-supporting-brain-health-diplomacy-leaders-in-latin-america-and-the-caribbean
#19
REVIEW
Walter D Dawson, Laura Booi, Maritza Pintado-Caipa, Maira Okada de Oliveira, Alex Kornhuber, Natasha Spoden, Ona Golonka, Lenny Shallcross, Alejandra Davidziuk, Márcia Regina Cominetti, Mayte Vergara-Manríquez, Renata Kochhann, Ian Robertson, Harris A Eyre, Agustin Ibáñez
Maintaining and improving brain health, one of the most critical global challenges of this century, necessitates innovative, interdisciplinary, and collaborative strategies to address the growing challenges in Latin America and the Caribbean. This paper introduces Brain Health Diplomacy (BHD) as a pioneering approach to bridge disciplinary and geographic boundaries and mobilize resources to promote equitable brain health outcomes in the region. Our framework provides a toolkit for emerging brain health leaders, equipping them with essential concepts and practical resources to apply in their professional work and collaborations...
December 2023: Lancet Reg Health Am
https://read.qxmd.com/read/38021355/analysis-of-prognostic-germline-polymorphisms-in-patients-with-advanced-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Michael Herman, Benjamin H Lok, Steven Gallinger, Laura Dawson, Raymond Kim, Dangxiao Cheng, Tara Paton, Roxana Bucur, Devalben Patel, Rouhi Fazelzad, Katrina Hueniken, Geoffrey Liu
BACKGROUND: The prognosis of hepatocellular carcinoma (HCC) is influenced by both tumor and patient specific factors. Current therapies of advanced HCC target angiogenesis and immune evasion, however there are no clinically useful biomarkers to guide clinicians. METHODS: Our aim in this retrospective cohort study was to validate single nucleotide polymorphisms (SNPs) prognostic of outcome in advanced HCC from the literature, and to analyze exploratory SNPs chosen from evaluation of the HCC tumor immune microenvironment...
2023: Translational Gastroenterology and Hepatology
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