Jiarui Xia, Di Wang, Wei Guo, Yangqing Pei, Lin Zhang, Lei Bao, Yiping Li, Yaqian Qu, Youliang Zhao, Changfu Hao, Wu Yao
Long-term exposure to inhalable silica particles may lead to severe systemic pulmonary disease, such as silicosis. Exosomes have been demonstrated to dominate the pathogenesis of silicosis, but the underlying mechanisms remain unclear. Therefore, this study aimed to explore the roles of exosomes by transmitting miR-107, which has been linked to the toxic pulmonary effects of silica particles. We found that miR-107, miR-122-5p, miR-125a-5p, miR-126-5p, and miR-335-5p were elevated in exosomes extracted from the serum of patients with silicosis...
March 22, 2024: International Journal of Biological Macromolecules