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https://www.readbyqxmd.com/read/29029348/dysregulation-of-sleep-behavioral-states-in-narcolepsy
#1
Sarah F Schoch, Esther Werth, Rositsa Poryazova, Thomas E Scammell, Christian R Baumann, Lukas L Imbach
Study Objectives: Patients with narcolepsy suffer from poor maintenance of wakefulness and fragmented night sleep, but the underlying mechanism of sleep boundary dysregulation remains little understood. The goal of this study was to quantify abnormal sleep-wake regulation in narcolepsy patients. Methods: Using a model-based approach (state space analysis), we analyzed overnight EEG recordings in ten patients with narcolepsy type 1 and age- and gender-matched healthy control subjects...
October 5, 2017: Sleep
https://www.readbyqxmd.com/read/29028627/local-dynamic-stability-during-treadmill-walking-can-detect-children-with-developmental-coordination-disorder
#2
Merete B Speedtsberg, Sofie B Christensen, Jan Stenum, Thomas Kallemose, Jesper Bencke, Derek J Curtis, Bente R Jensen
OBJECTIVE: Developmental coordination disorder (DCD) is an innate impairment of motor coordination that affects basic locomotion and balance. This study investigated local dynamic stability of trunk accelerations during treadmill walking as an objective evaluation of gait stability and the sensitivity and specificity of this measure to discriminate children with DCD from typically developing children. METHOD: Eight children with DCD and ten age- and gender-matched typically developing children (TD) walked four minutes on a treadmill...
October 5, 2017: Gait & Posture
https://www.readbyqxmd.com/read/29028592/elevation-of-plasma-neutrophil-gelatinase-associated-lipocalin-ngal-levels-in-schizophrenia-patients
#3
Li Wei, Yupeng Du, Wei Wu, Xuyan Fu, Qi Xia
BACKGROUND: Psychiatric diseases are usually accompanied by immune dysregulation and activation of the inflammatory response system. However, the characteristics of immunoinflammatory markers in psychiatric diseases are not well defined. METHODS: Seventy-three patients with psychiatric diseases were divided into four groups, including a schizophrenia group, an anxiety disorder group, a unipolar depression group, and a bipolar disorder group, according to the ICD-10 and DSM-IV codes...
October 3, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/29028365/exploring-self-care-and-preferred-supports-for-adult-parents-in-recovery-from-substance-use-disorders-qualitative-findings-from-a-feasibility-study
#4
Phyllis A Raynor, Charlene Pope, Janet York, Gigi Smith, Martina Mueller
Very little is known about the self-care behaviors (SCB) that adult parents employ and the preferred supports they utilize to maintain their recovery from substance use disorders (SUD) while also parenting their children. This study used a qualitative descriptive approach to explore perceptions of self-care and parenting to inform future self-care interventions for parents in early recovery. Nineteen mothers and fathers of at least one child between the ages of 6-18 were interviewed by telephone about parental self-care practices while in recovery from SUD, recovery management, and preferred supports in the community...
October 13, 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/29027725/severity-of-ineffective-esophageal-motility-is-associated-with-utilization-of-skeletal-muscle-relaxant-medications
#5
V Rangan, N S George, F Khan, Z Geng, S Gabbard, A Kichler, H Gittleman, R Fass
BACKGROUND: Ineffective esophageal motility (IEM) is the most common finding on high-resolution esophageal manometry (HREM). The underlying mechanisms for IEM remain to be fully elucidated. The aim of this study was to determine if utilization of skeletal muscle relaxants is associated with IEM, and with more severe subtypes of the disorder. METHODS: Patients with diagnosis of IEM were gender and age matched to patients with normal HREM. Demographic information, symptoms, endoscopic findings, medication usage and medical comorbidities were recorded...
October 13, 2017: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29027646/prevalence-of-obstructive-sleep-apnea-among-obese-toddlers-and-preschool-children
#6
Saadoun Bin-Hasan, Sherri Katz, Zoe Nugent, Joy Nehme, Zihang Lu, Abdullah Khayat, Suhail Al-Saleh, Reshma Amin, Indra Narang
BACKGROUND: Obstructive sleep apnea (OSA) is a common disorder estimated at 1-5% in the school-aged children. With the obesity prevalence reaching staggering rates globally, OSA in obese adolescents is estimated to be 4-5-folds higher than their lean peers. There is a paucity of data regarding obesity-related OSA in children 6 years and less. This is particularly relevant as OSA is associated with neurocognitive deficits. The aim of this study is to evaluate the prevalence of OSA among obese toddlers and preschool children and further to determine what other factors may be associated with the presence of OSA...
October 13, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/29026790/the-prevalence-of-hearing-impairment-by-age-and-gender-in-a-population-based-study
#7
Alimohamad Asghari, Mohammad Farhadi, Ahmad Daneshi, Mehdi Khabazkhoob, Saman Mohazzab-Torabi, Maryam Jalessi, Hesamedin Emamjomeh
BACKGROUND: This study aimed to determine the prevalence of hearing impairment (HI) by age and gender in a population aged 5 yr and older residing in Tehran, Iran. METHODS: In this cross-sectional study, 140 clusters each including 10 households from Tehran, Iran were sampled between 2012 and 2013 using cluster random sampling. Trained audiologists examined the participants during face-to-face interviews. The hearing of the participants was evaluated before the removal of wax or other foreign bodies...
September 2017: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/29026764/a-case-control-study-on-environmental-and-biological-risk-factors-for-renal-calculi-persisting-in-a-coastal-union-territory-india
#8
Prakash Mathiyalagen, Anand Neelakantan, Karthik Balusamy, Kavita Vasudevan, Johnson Cherian, Bhuvaneswary Sunderamurthy
BACKGROUND AND OBJECTIVES: Renal stone disease is a common disorder of the urinary tract and also a significant problem because of incidence, recurrence, and severe consequences. The complex pathogenetic mechanisms of renal stone formation involve both biologic and environmental risk factors. The present study was performed to identify the role of these parameters among renal stone patients and normal individuals from a coastal union territory region in South India. METHODS: The authors conducted a case-control study of renal stone disease among outpatient department patients more than 30 years of age using systematic random sampling procedure with 100 study participants (50 subjects for each group)...
January 2017: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/29026401/the-sensitivity-of-na-k-atpase-as-an-indicator-of-blood-diseases
#9
Abulnaja Kkalid Omar, Kherd Ali Ahmed, Nawal Mohammed Helmi, Kumosani Taha Abdullah, Mohamad H Qarii, Huwait Etimad Hasan, Albukhari Ashwag, Alaama Mohammed Nabil, Al-Ghamdi Maryam Abdu, Moselhy Said Salama
BACKGROUND: Blood-related hereditary diseases are widespread in Eastern and SouthWestern regions of Saudi Arabia until recently. In this study, we used Na(+), K(+)ATPase as an enzymatic indicator for the diagnosis of the diseases. MATERIALS AND METHODS: Individuals with different blood diseases (iron deficiency (n=13), anemia (n=14), thalassemia (n=16) and sickle cell anemia (n=12) were studied for Na(+), K(+)-ATPase activity in the plasma membrane of red blood cell and compared with those of the healthy ones (n=20) of the same age and gender living in Jeddah, Saudi Arabia...
March 2017: African Health Sciences
https://www.readbyqxmd.com/read/29024219/the-determinants-of-service-complexity-in-children-with-intellectual-disabilities
#10
S L Stewart, K Falah Hassani, J Poss, J Hirdes
BACKGROUND: To date, little is known about the predictors of healthcare service utilisation in children with intellectual disability (ID). The aim of this study was to identify the factors associated with service complexity in children with ID in Ontario, Canada. METHODS: The population of this cross-sectional study consisted of 330 children with ID ages 4 to 18 years who accessed mental health services from November of 2012 to June of 2016 in four agencies. All participants completed the interRAI Child and Youth Mental Health and Developmental Disability Assessment Instrument, which is a semi-structured clinician-rated assessment that covers a range of common issues in children with ID...
November 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/29022655/anosognosia-is-an-independent-predictor-of-conversion-from-mild-cognitive-impairment-to-alzheimer-s-disease-and-is-associated-with-reduced-brain-metabolism
#11
Philip Gerretsen, Jun Ku Chung, Parita Shah, Eric Plitman, Yusuke Iwata, Fernando Caravaggio, Shinichiro Nakajima, Bruce G Pollock, Ariel Graff-Guerrero
OBJECTIVE: Anosognosia, or impaired illness awareness, is a common feature of Alzheimer's disease (AD) and less so of mild cognitive impairment (MCI). Importantly, anosognosia negatively influences clinical outcomes for patients and their caregivers and may predict the conversion from MCI to AD. This study aimed to examine (1) the relationship between brain glucose metabolism as measured by fluorine-18 fluorodeoxyglucose positron emission tomography (FDG-PET) and anosognosia in patients with MCI and AD and (2) the predictive utility of anosognosia in patients with MCI for later conversion to AD, even when controlling for other factors, including gender, education, apolipoprotein E ε4 carrier status, dementia severity, and cognitive dysfunction...
October 10, 2017: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29022221/eating-disorder-symptoms-and-the-2%C3%A2-%C3%A3-%C3%A2-2-model-of-perfectionism-mixed-perfectionism-is-the-most-maladaptive-combination
#12
Rita Maria Esposito, Joachim Stoeber, Lavinia E Damian, Guido Alessandri, Caterina Lombardo
PURPOSE: The 2 × 2 model of perfectionism (Gaudreau and Thompson in Personal Individ Diff 48:532-537, 2010) represents an important addition to the perfectionism literature, but so far has not been studied in relation with disordered eating. METHOD: Using the 2 × 2 model as analytic framework, this study examined responses from a convenience sample of 716 participants aged 19-68 years (71% female) investigating how self-oriented perfectionism (SOP) and socially prescribed perfectionism (SPP) predicted individual differences in eating disorder symptoms, additionally controlling for body mass index, gender, and age...
October 11, 2017: Eating and Weight Disorders: EWD
https://www.readbyqxmd.com/read/29022138/associated-and-mediating-variables-related-to-quality-of-life-among-service-users-with-mental-disorders
#13
Marie-Josée Fleury, Guy Grenier, Jean-Marie Bamvita
PURPOSE: This study aimed to identify variables associated with quality of life (QoL) and mediating variables among 338 service users with mental disorders in Quebec (Canada). Data were collected using nine standardized questionnaires and participant medical records. METHODS: Quality of life was assessed with the Satisfaction with Life Domains Scale. Independent variables were organized into a six-block conceptual framework. Using structural equation modeling, associated and mediating variables related to QoL were identified...
October 11, 2017: Quality of Life Research
https://www.readbyqxmd.com/read/29022055/illness-perceptions-are-associated-with-quality-of-life-in-patients-with-fibrous-dysplasia
#14
B C J Majoor, C D Andela, C R Quispel, M Rotman, P D S Dijkstra, N A T Hamdy, A A Kaptein, N M Appelman-Dijkstra
Fibrous dysplasia (FD) is a rare bone disorder in which normal bone is replaced by fibrous tissue resulting in pain, deformities, pathological fractures or asymptomatic disease. Illness perceptions are patients' cognitions and emotions about their illness and its treatment, which may impact on Quality of Life (QoL). Here, we explore illness perceptions in patients with FD compared to other disorders, identify factors associated with illness perceptions and evaluate their relationship with QoL. Ninety-seven out of 138 eligible patients from the LUMC FD cohort completed the Illness Perception Questionnaire-Revised (IPQ-R) and the Short Form-36 (SF-36)...
October 11, 2017: Calcified Tissue International
https://www.readbyqxmd.com/read/29021921/post-transplant-lymphoproliferative-disorder-ptld-single-institutional-experience-of-141-patients
#15
Rohit Bishnoi, Ravneet Bajwa, Aaron J Franke, William Paul Skelton, Yu Wang, Niraj M Patel, William Birdsall Slayton, Fei Zou, Nam H Dang
BACKGROUND: Post-transplant lymphoproliferative disorder is a well-recognized but rare complication of hematopoietic stem cell and solid organ transplant. Due to rarity of this disease, retrospective studies from major transplant centers has been the main source to provide treatment guidelines, which are still in evolution. The sample size of this study is among one of the largest study on PTLD till date reported throughout the world. METHODS: This study was performed at University of Florida which is one of the largest transplant center in South East United States...
2017: Experimental Hematology & Oncology
https://www.readbyqxmd.com/read/29021889/linguistic-camouflage-in-girls-with-autism-spectrum-disorder
#16
Julia Parish-Morris, Mark Y Liberman, Christopher Cieri, John D Herrington, Benjamin E Yerys, Leila Bateman, Joseph Donaher, Emily Ferguson, Juhi Pandey, Robert T Schultz
BACKGROUND: Autism spectrum disorder (ASD) is diagnosed more frequently in boys than girls, even when girls are equally symptomatic. Cutting-edge behavioral imaging has detected "camouflaging" in girls with ASD, wherein social behaviors appear superficially typical, complicating diagnosis. The present study explores a new kind of camouflage based on language differences. Pauses during conversation can be filled with words like UM or UH, but research suggests that these two words are pragmatically distinct (e...
2017: Molecular Autism
https://www.readbyqxmd.com/read/29021824/intense-obsessional-interests-in-children-with-gender-dysphoria-a-cross-validation-study-using-the-teacher-s-report-form
#17
Kenneth J Zucker, A Natisha Nabbijohn, Alanna Santarossa, Hayley Wood, Susan J Bradley, Joanna Matthews, Doug P VanderLaan
OBJECTIVE: This study assessed whether children clinically referred for gender dysphoria (GD) show symptoms that overlap with Autism Spectrum Disorder (ASD). Circumscribed preoccupations/intense interests and repetitive behaviors were considered as overlapping symptoms expressed in both GD and ASD. METHODS: To assess these constructs, we examined Items 9 and 66 on the Teacher's Report Form (TRF), which measure obsessions and compulsions, respectively. RESULTS: For Item 9, gender-referred children (n = 386) were significantly elevated compared to the referred (n = 965) and non-referred children (n = 965) from the TRF standardization sample...
2017: Child and Adolescent Psychiatry and Mental Health
https://www.readbyqxmd.com/read/29019705/validation-of-a-difficulty-grading-score-in-laparoscopic-splenectomy
#18
Diana Gonçalves, Marina Morais, André Costa-Pinho, Renato Bessa-Melo, Luís Graça, J Costa-Maia
INTRODUCTION: Laparoscopic splenectomy (LS) is the gold standard for the treatment of many spleen-related disorders. However, in the presence of splenomegaly, the rate of conversion to open surgery can be as high as 33.9% and is associated with longer operative times and higher costs. In an attempt to improve risk stratification and patient selection for LS, a score that includes four preoperative parameters (age, gender, diagnosis, and spleen size) has been developed. The aim was the validation of a difficulty grading score, in predicting conversion and poorer outcomes...
October 11, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29019523/mental-disorders-and-employment-status-in-the-s%C3%A3-o-paulo-metropolitan-area-brazil-gender-differences-and-use-of-health-services
#19
Mariane Henriques França, Sandhi Maria Barreto, Flavia Garcia Pereira, Laura Helena Silveira Guerra de Andrade, Maria Cristina Alochio de Paiva, Maria Carmen Viana
Mental disorders are associated with employment status as significant predictors and as consequences of unemployment and early retirement. This study describes the estimates and associations of 12-month DSM-IV prevalence rates of mental disorders and use of health services with employment status by gender in the São Paulo Metropolitan Area, Brazil. Data from the São Paulo Megacity Mental Health Survey was analyzed (n = 5,037). This is a population-based study assessing the prevalence and determinants of mental disorders among adults, using the Composite International Diagnostic Interview...
October 9, 2017: Cadernos de Saúde Pública
https://www.readbyqxmd.com/read/29018891/-depression-and-anxiety-prevalence-among-ent%C3%A2-outpatients
#20
D Kleemann, A Kresin, H Kleemann
BACKGROUND: Few data exist on the prevalence of comorbid mental disorders among ENT patients. This investigation aimed to assess the prevalence of two disorders frequent in our society, namely depression and anxiety, in patients of an ENT outpatient clinic. PATIENTS AND METHODS: During a 2‑week period, 101 consecutive patients were interviewed with the Beck Depression Inventory-II (BDI II) and Beck Anxiety Inventory (BAI) screening aids. RESULTS: Of 97 evaluated tests, 38% contained indications of a psychiatric problem or mental comorbidity...
October 10, 2017: HNO
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