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https://www.readbyqxmd.com/read/28916449/bio-scaffolds-in-organ-regeneration-clinical-potential-and-current-challenges
#1
REVIEW
S Yesmin, M B Paget, H E Murray, R Downing
Cadaveric organ transplantation represents the definitive treatment option for end-stage disease but is restricted by the shortage of clinically-viable donor organs. This limitation has, in part, driven current research efforts for in vitro generation of transplantable tissue surrogates. Recent advances in organ reconstruction have been facilitated by the re-purposing of decellularized whole organs to serve as three-dimensional bio-scaffolds. Notably, studies in rodents indicate that such scaffolds retain native extracellular matrix components that provide appropriate biochemical, mechanical and physical stimuli for successful tissue/organ reconstruction...
September 12, 2017: Current Research in Translational Medicine
https://www.readbyqxmd.com/read/28913804/doubled-haploid-laboratory-protocol-for-wheat-using-wheat-maize-wide-hybridization
#2
Meenakshi Santra, Hong Wang, Scott Seifert, Scott Haley
In traditional wheat breeding, the uniformity of lines derived from a breeding population is obtained by repeated selfing from the F1 which takes several generations to reach homozygosity in loci controlling traits of interest. Using doubled haploid technology, however, it is possible to attain 100% homozygosity at all loci in a single generation and completely homogeneous breeding lines can be obtained in 1-2 years. Thus, doubled haploid technology may significantly reduce cultivar development time. Two major methods for producing wheat doubled haploids are androgenesis (anther culture and microspore culture) and embryo culture using wheat-maize wide hybridization, the latter being the most effective and widely used method...
2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28911305/alginate-based-cell-microencapsulation-for-tissue-engineering-and-regenerative-medicine
#3
Vittoria Pandolfi, Ulysse Pereira, Murielle Dufresne, Cécile Legallais
Increasing numbers of requests for transplantable organs and their scarcity has led to a pressing need to find alternative solutions to standard transplantation. An appealing but challenging proposal came from the fields of tissue engineering and regenerative medicine, the purpose of which is to build tissues/organs from scratch in the laboratory and use them as either permanent substitutes for direct implantation into the patient's body, or as temporary substitutes to bridge patients until organ regeneration or transplantation...
June 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28895293/photoactuation-healing-of-%C3%AE-feooh-g-c3-n4-catalyst-for-efficient-and-stable-activation-of-persulfate
#4
Gong Zhang, Zhang Wu, Huijuan Liu, Qinghua Ji, Jiuhui Qu, Jinghong Li
Inspired by living systems, the construction of smart devices that can self-heal in response to structural damage is a promising technology for maintaining the high activity and stability of catalysts during heterocatalytic reactions. Here this study demonstrates an ingenious platform that enabled efficient persulfate (PS) activation for contaminant degradation via integrating a catalyst with photoactuation regeneration. Under irradiation, it is unambiguously confirmed that the collective properties of a tailored FeOOH@C3 N4 catalyst permit interfacial photoexcited electron transport from the photocatalyst substrate to needle-shaped FeOOH...
September 12, 2017: Small
https://www.readbyqxmd.com/read/28893049/comparative-evaluation-of-the-efficacy-of-bioactive-ceramic-composite-granules-alone-and-in-combination-with-platelet-rich-fibrin-in-the-treatment-of-mandibular-class-ii-furcation-defects-a-clinical-and-radiographic-study
#5
Hima S Lohi, Dilip G Nayak, Ashita S Uppoor
INTRODUCTION: Predictable closure of furcation defects with bone grafts, Guided Tissue Regeneration (GTR) and a combination of the two has remained an elusive goal so far. Hence, evaluation of biomimetic agents as candidate technologies for periodontal regeneration merit due consideration. In this study, Choukroun's Platelet Rich Fibrin (PRF), a second generation platelet concentrate, is combined with bone graft to examine if the addition enhances the therapeutic potential of bone graft in the management of Class II furcation defects...
July 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28892868/assessing-the-feasibility-of-integrating-ecosystem-based-with-engineered-water-resource-governance-and-management-for-water-security-in-semi-arid-landscapes-a-case-study-in-the-banas-catchment-rajasthan-india
#6
Mark Everard, Om Prakash Sharma, Vinod Kumar Vishwakarma, Dharmendra Khandal, Yogesh K Sahu, Rahul Bhatnagar, Jitendra K Singh, Ritesh Kumar, Asghar Nawab, Amit Kumar, Vivek Kumar, Anil Kashyap, Deep Narayan Pandey, Adrian C Pinder
Much of the developing world and areas of the developed world suffer water vulnerability. Engineering solutions enable technically efficient extraction and diversion of water towards areas of demand but, without rebalancing resource regeneration, can generate multiple adverse ecological and human consequences. The Banas River, Rajasthan (India), has been extensively developed for water diversion, particularly from the Bisalpur Dam from which water is appropriated by powerful urban constituencies dispossessing local people...
September 7, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28892354/hydrophilic-and-compressible-aerogel-a-novel-draw-agent-in-forward-osmosis
#7
Mingchuan Yu, Hanmin Zhang, Fenglin Yang
Forward osmosis (FO) technology is an efficient route to obtain purity water for drinking from wastewater or seawater. However, there are some challenges in draw solution to limit its application. We firstly introduce a novel sodium alginate-graphene oxide (SA-GO) aerogel as draw agent for highly efficient FO process. The GO nanosheets covalently cross-linked to SA matrix to form a three-dimensional and highly porous aerogel to provide excellent water flux and operation stability, together with the property of compressibility served by SA-GO aerogel resulting in easy water production and regeneration process...
September 11, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28892028/microfluidic-dry-spinning-and-characterization-of-regenerated-silk-fibroin-fibers
#8
Qingfa Peng, Huili Shao, Xuechao Hu, Yaopeng Zhang
The protocol demonstrates a method for mimicking the spinning process of silkworm. In the native spinning process, the contracting spinning duct enables the silk proteins to be compact and ordered by shearing and elongation forces. Here, a biomimetic microfluidic channel was designed to mimic the specific geometry of the spinning duct of the silkworm. Regenerated silk fibroin (RSF) spinning doped with high concentration, was extruded through the microchannel to dry-spin fibers at ambient temperature and pressure...
September 4, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28889745/self-bleaching-behaviors-in-black-to-transmissive-electrochromic-polymer-thin-films
#9
Jiazhi He, Liyan You, Jianguo Mei
Polymer-based electrochromic smart window is an emerging energy-saving technology. There are several technological hurdles in the development of organic electrochromics. In this article, self-bleaching behaviors of a black electrochromic polymer (ECP-Black) thin film were investigated. We found that the electrochemical break-in process led to a less dense morphology and the increased free volume facilitated ion permeation in the ECP-Black thin films. The polarized interface between polymer thin film and transparent indium-tin-oxide (ITO) electrode made charge transfer accessible, which caused the self-bleaching behaviors...
September 9, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28886764/advanced-scaffolds-for-dental-pulp-and-periodontal-regeneration
#10
REVIEW
Marco C Bottino, Divya Pankajakshan, Jacques E Nör
No current therapy promotes root canal disinfection and regeneration of the pulp-dentin complex in cases of pulp necrosis. Antibiotic pastes used to eradicate canal infection negatively affect stem cell survival. Three-dimensional easy-to-fit antibiotic-eluting nanofibers, combined with injectable scaffolds, enriched or not with stem cells and/or growth factors, may increase the likelihood of achieving predictable dental pulp regeneration. Periodontitis is an aggressive disease that impairs the integrity of tooth-supporting structures and may lead to tooth loss...
October 2017: Dental Clinics of North America
https://www.readbyqxmd.com/read/28884292/the-advancement-of-biomaterials-in-regulating-stem-cell-fate
#11
REVIEW
Vun Vun Hiew, Siti Fatimah Binti Simat, Peik Lin Teoh
Stem cells are well-known to have prominent roles in tissue engineering applications. Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) can differentiate into every cell type in the body while adult stem cells such as mesenchymal stem cells (MSCs) can be isolated from various sources. Nevertheless, an utmost limitation in harnessing stem cells for tissue engineering is the supply of cells. The advances in biomaterial technology allows the establishment of ex vivo expansion systems to overcome this bottleneck...
September 7, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/28877649/the-effect-of-hypothermic-and-cryogenic-preservation-on-engineered-neural-tissue
#12
Adam George Edward Day, Kulraj Singh Bhangra, Celia Murray-Dunning, Lara Stevanato, James Phillips
This study explored different approaches to preserve Engineered Neural Tissue (EngNT), a stabilised cellular collagen hydrogel containing columns of aligned Schwann cells for nervous system repair. The ability to preserve EngNT without disrupting cellular and extracellular components and structures is important for clinical translation and commercialisation. Stabilised cellular gels and EngNT constructs were preserved under various conditions and cell survival assessed using live/dead microscopy and metabolic assay...
September 6, 2017: Tissue Engineering. Part C, Methods
https://www.readbyqxmd.com/read/28875984/multiscale-technologies-for-treatment-of-ischemic-cardiomyopathy
#13
REVIEW
Morteza Mahmoudi, Mikyung Yu, Vahid Serpooshan, Joseph C Wu, Robert Langer, Richard T Lee, Jeffrey M Karp, Omid C Farokhzad
The adult mammalian heart possesses only limited capacity for innate regeneration and the response to severe injury is dominated by the formation of scar tissue. Current therapy to replace damaged cardiac tissue is limited to cardiac transplantation and thus many patients suffer progressive decay in the heart's pumping capacity to the point of heart failure. Nanostructured systems have the potential to revolutionize both preventive and therapeutic approaches for treating cardiovascular disease. Here, we outline recent advancements in nanotechnology that could be exploited to overcome the major obstacles in the prevention of and therapy for heart disease...
September 6, 2017: Nature Nanotechnology
https://www.readbyqxmd.com/read/28873283/in-vivo-like-culture-conditions-in-a-bioreactor-facilitate-improved-tissue-quality-in-corneal-storage
#14
Richard Schmid, Ioana-Sandra Tarau, Angela Rossi, Stefan Leonhardt, Thomas Schwarz, Sebastian Schuerlein, Christian Lotz, Jan Hansmann
The cornea is the most-transplanted tissue worldwide. However, the availability and quality of grafts are limited due to the current methods of corneal storage. In this study, a dynamic bioreactor system is employed to enable the control of intraocular pressure and the culture at the air-liquid interface. Thereby, in vivo-like storage conditions are achieved. Different media combinations for endothelium and epithelium are tested in standard and dynamic conditions to enhance the viability of the tissue. In contrast to culture conditions used in eye banks, the combination of the bioreactor and biochrom medium 1 allows to preserve the corneal endothelium and the epithelium...
September 5, 2017: Biotechnology Journal
https://www.readbyqxmd.com/read/28866278/precise-immune-tolerance-for-hpsc-derivatives-in-clinical-application
#15
Wenliang Zhu, Mengqi Li, Yihui Wu, Baoyang Hu
Human pluripotent stem cells (hPSCs) promise a foreseeing future for regeneration medicine and cell replacement therapy with their abilities to produce almost any types of somatic cells of the body. The complicated immunogenicity of hPSC derivatives and context dependent responses in variable transplantations greatly hurdle the practical application of hPSCs in clinic. Especially for applications of hPSCs, induction of immune tolerance at the same time increases the risks of tumorigenesis. Over the past few years, thanks to the progress in immunology and practices in organ transplantation, endeavors on exploring strategies to induce long term protection of allogeneic transplants have shed light on overcoming this barrier...
August 30, 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28865805/de-novo-root-regeneration-from-leaf-explants-wounding-auxin-and-cell-fate-transition
#16
REVIEW
Lin Xu
Root organogenesis after tissue damage is a type of plant regeneration known as de novo root regeneration (DNRR). The DNRR process is widely exploited in agricultural technologies, such as cuttings for vegetative propagation. This review summarizes recent advances in our understanding of the cellular and molecular framework of DNRR, mainly focusing on rooting from Arabidopsis thaliana leaf explants. The framework comprises three successive phases, that is, early signaling, auxin accumulation, and cell fate transition, and involves two types of cells with different functions: the converter cell that converts the early signals as the input into auxin flux as the output; and the regeneration-competent cell that undergoes fate transition guided by auxin...
August 30, 2017: Current Opinion in Plant Biology
https://www.readbyqxmd.com/read/28865273/designer-carbon-nanotubes-for-contaminant-removal-in-water-and-wastewater-a-critical-review
#17
REVIEW
Binoy Sarkar, Sanchita Mandal, Yiu Fai Tsang, Pawan Kumar, Ki-Hyun Kim, Yong Sik Ok
The search for effective materials for environmental cleanup is a scientific and technological issue of paramount importance. Among various materials, carbon nanotubes (CNTs) possess unique physicochemical, electrical, and mechanical properties that make them suitable for potential applications as environmental adsorbents, sensors, membranes, and catalysts. Depending on the intended application and the chemical nature of the target contaminants, CNTs can be designed through specific functionalization or modification processes...
August 30, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28859577/single-cell-sequencing-technologies-for-cardiac-stem-cell-studies
#18
Tiantian Liu, Hongjin Wu, Shixiu Wu, Charles Wang
Today with the rapid advancements in stem cell studies and the promising potential of using stem cells in clinical therapy, there is an increasing demand for in-depth comprehensive analysis on individual cell transcriptome and epigenome, as they play critical roles in a number of cell functions such as cell differentiation, growth and reprogramming. The development of single-cell sequencing technologies has helped in revealing some exciting new perspectives in stem cells and regenerative medicine research. Among the various potential applications, single-cell analysis for cardiac stem cells (CSCs) holds tremendous promises in understanding the mechanisms of heart development and regeneration, which might light up the path towards cell therapy for cardiovascular diseases...
August 31, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/28859517/a-novel-approach-for-meniscal-regeneration-using-kartogenin-treated-autologous-tendon-graft
#19
He Huang, Hongyao Xu, Jianning Zhao
BACKGROUND: The meniscus is one of the most commonly injured parts of the body, and meniscal healing is difficult. HYPOTHESIS: Kartogenin (KGN) induces tendon stem cells (TSCs) to differentiate into cartilage cells in vitro and form meniscus-like tissue in vivo. A damaged meniscus can be replaced with a KGN-treated autologous tendon graft. STUDY DESIGN: Controlled laboratory study. METHODS: In the in vitro experiments, TSCs were isolated from rabbit patellar tendons and cultured with various concentrations of KGN, from 0 to 1000 µM...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28855020/applicability-of-zeolite-based-systems-for-ammonia-removal-and-recovery-from-wastewater
#20
Pallabi Das, Bably Prasad, Krishna Kant Kumar Singh
  Ammonia discharged in industrial effluents bears deleterious effects and necessitates remediation. Integrated systems devoted to recovery of ammonia in a useful form and remediation of the same addresses the challenges of waste management and its utilization. A comparative performance evaluation study was undertaken to access the suitability of different zeolite based systems (commercial zeolites and zeolites synthesized from fly ash) for removal of ammonia followed by its subsequent release. Four main parameters which were studied to evaluate the applicability of such systems for large scale usage are cost-effectiveness, ammonia removal efficiency, performance on regeneration, and ammonia release percentage...
September 1, 2017: Water Environment Research: a Research Publication of the Water Environment Federation
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