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https://www.readbyqxmd.com/read/28094979/photo-induced-cross-linking-of-short-furan-modified-dna-on-surfaces
#1
Cinthya Yamila Véliz Montes, Henry Memczak, Ellen Gyssels, Tomas Torres, Annemieke Madder, Rudolf J Schneider
We report for the first time the formation of site-specifically interstrand cross-linked (ICL) surface-immobilized furan-modified DNA duplexes via singlet oxygen. 1O2, necessary for effecting furan-mediated ICL formation, was produced in situ using methylene blue or a zinc phthalocyanine derivative (TT1) as photosensitizers. Via surface plasmon resonance spectroscopy we show that surface ICL was achieved and established a robust link which enhances the stability of the 12-mer duplex even after surface regeneration...
January 17, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28088667/cell-laden-hydrogels-for-osteochondral-and-cartilage-tissue-engineering
#2
REVIEW
Jingzhou Yang, Yu Shrike Zhang, Kan Yue, Ali Khademhosseini
: Despite tremendous advances in the field of regenerative medicine, it still remains challenging to repair the osteochondral interface and full-thickness articular cartilage defects. This inefficiency largely originates from the lack of appropriate tissue engineered artificial matrices that can replace the damaged regions and promote tissue regeneration. Hydrogels are emerging as a promising class of biomaterials for both soft and hard tissue regeneration. Many critical properties of hydrogels, such as mechanical stiffness, elasticity, water content, bioactivity, and degradation, can be rationally designed and conveniently tuned by proper selection of the material and chemistry...
January 11, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28087378/new-scaffolds-encapsulating-tgf-%C3%AE-3-bmp-7-combinations-driving-strong-chondrogenic-differentiation
#3
Jose Crecente-Campo, Erea Borrajo, Anxo Vidal, Marcos Garcia-Fuentes
The regeneration of articular cartilage remains an unresolved question despite the current access to a variety of tissue scaffolds activated with growth factors relevant to this application. Further advances might result from combining more than one of these factors; here, we propose a scaffold composition optimized for the dual delivery of BMP-7 and TGF-β3, two proteins with described chondrogenic activity. First, we tested in a mesenchymal stem cell micromass culture with TGF-β3 whether the exposure to microspheres loaded with BMP-7 would improve cartilage formation...
January 10, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28086788/comprehensive-circrna-expression-profile-and-selection-of-key-circrnas-during-priming-phase-of-rat-liver-regeneration
#4
Lifei Li, Jianlin Guo, Yanhui Chen, Cuifang Chang, Cunshuan Xu
BACKGROUND: Rat liver regeneration (LR) proceeds along a process of highly organized and ordered tissue growth in response to the loss or injury of liver tissue, during which many physiological processes may play important roles. The molecular mechanism of hepatocyte proliferation, energy metabolism and substance metabolism during rat LR had been elucidated. Further, the correlation of circular RNA (circRNA) abundance with proliferation has recently been clarified. However, the regulatory capacity of circRNA in rat LR remains a fascinating topic...
January 13, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28069224/a-method-for-water-well-regeneration-based-on-shock-waves-and-ultrasound
#5
Anna V Abramova, Vladimir O Abramov, Vadim M Bayazitov, Roman V Nikonov
The regeneration of water wells is an urgent problem nowadays, when drilling of new wells becomes more and more expensive. Formation damage leads to a reduction of the formation's permeability and/or pore volume which in turn inhibits the ability of the water to flow from the reservoir formation into the wellbore. A new technology that uses high-power ultrasound to remove formation damage of water wells has been developed. The effectiveness of regeneration of wells can be enhanced if ultrasound and shockwaves are used during the same treatment...
May 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/28057791/from-microscale-devices-to-3d-printing-advances-in-fabrication-of-3d-cardiovascular-tissues
#6
REVIEW
Anton V Borovjagin, Brenda M Ogle, Joel L Berry, Jianyi Zhang
Current strategies for engineering cardiovascular cells and tissues have yielded a variety of sophisticated tools for studying disease mechanisms, for development of drug therapies, and for fabrication of tissue equivalents that may have application in future clinical use. These efforts are motivated by the need to extend traditional 2-dimensional (2D) cell culture systems into 3D to more accurately replicate in vivo cell and tissue function of cardiovascular structures. Developments in microscale devices and bioprinted 3D tissues are beginning to supplant traditional 2D cell cultures and preclinical animal studies that have historically been the standard for drug and tissue development...
January 6, 2017: Circulation Research
https://www.readbyqxmd.com/read/28056209/fractional-co2-laser-from-skin-rejuvenation-to-vulvo-vaginal-reshaping
#7
Maurizio Filippini, Ester Del Duca, Francesca Negosanti, Diletta Bonciani, Luca Negosanti, Mario Sannino, Giovanni Cannarozzo, Steven Paul Nisticò
BACKGROUND: The CO2 laser has become the gold standard treatment in dermatologic surgery for the treatment of a large number of skin and mucosal lesions. The introduction of the fractional micro-ablative technology represented an integration to the ablative resurfacing technique, reducing the healing time and the side effects. OBJECTIVE: Vaginal rejuvenation performed with this technique is a minimally invasive procedure that stimulates internal tissues of the female lower genital tract to regenerate the mucosa, improving tissue trophism and restoring the correct functionality...
December 30, 2016: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28045504/will-aerosol-hygroscopicity-change-with-biodiesel-renewable-diesel-fuels-and-emission-control-technologies
#8
Diep Vu, Daniel Z Short, Georgios Karavalakis, Thomas D Durbin, Akua Asa-Awuku
The use of biodiesel and renewable diesel fuels in compression ignition engines and aftertreatment technologies may affect vehicle exhaust emissions. In this study two 2012 light-duty vehicles equipped with direct injection diesel engines, diesel oxidation catalyst (DOC), diesel particulate filter (DPF), and selective catalytic reduction (SCR) were tested on a chassis dynamometer. One vehicle was tested over the Federal Test Procedure (FTP) cycle on seven biodiesel and renewable diesel fuel blends. Both vehicles were exercised over double Environmental Protection Agency (EPA) Highway fuel economy test (HWFET) cycles on ultra-low sulfur diesel (ULSD) and a soy-based biodiesel blend to investigate the aerosol hygroscopicity during the regeneration of the DPF...
January 3, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28034512/characterization-of-the-natural-radioactivity-of-the-first-deep-geothermal-doublet-in-flanders-belgium
#9
M Vasile, M Bruggeman, S Van Meensel, S Bos, B Laenen
Deep geothermal energy is a local energy resource that is based on the heat generated by the Earth. As the heat is continuously regenerated, geothermal exploitation can be considered as a renewable and, depending on the techniques used, a sustainable energy production system. In September 2015, the Flemish Institute for Technological Research (VITO) started drilling an exploration well targeting a hot water reservoir at a depth of about 3km on the Balmatt site near Mol. Geothermal hot water contains naturally occurring gases, chemicals and radionuclides at variable concentrations...
December 20, 2016: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/28030802/inhibition-of-the-fibroblast-growth-factor-receptor-fgfr-pathway-the-current-landscape-and-barriers-to-clinical-application
#10
REVIEW
Young Kwang Chae, Keerthi Ranganath, Peter S Hammerman, Christos Vaklavas, Nisha Mohindra, Aparna Kalyan, Maria Matsangou, Ricardo Costa, Benedito Carneiro, Victoria M Villaflor, Massimo Cristofanilli, Francis J Giles
The fibroblast growth factor/fibroblast growth factor receptor (FGF/FGFR) is a tyrosine kinase signaling pathway that has a fundamental role in many biologic processes including embryonic development, tissue regeneration, and angiogenesis. Increasing evidence indicates that this pathway plays a critical role in oncogenesis via gene amplification, activating mutations, or translocation in tumors of various histologies. With multiplex sequencing technology, the detection of FGFR aberrations has become more common and is tied to cancer cell proliferation, resistance to anticancer therapies, and neoangiogenesis...
December 22, 2016: Oncotarget
https://www.readbyqxmd.com/read/28019053/prestructural-cartilage-assessment-using-mri
#11
Thomas M Link, Jan Neumann, Xiaojuan Li
: Cartilage loss is irreversible, and to date, no effective pharmacotherapies are available to protect or regenerate cartilage. Quantitative prestructural/compositional MR imaging techniques have been developed to characterize the cartilage matrix quality at a stage where abnormal findings are early and potentially reversible, allowing intervention to halt disease progression. The goal of this article is to critically review currently available technologies, present the basic concept behind these techniques, but also to investigate their suitability as imaging biomarkers including their validity, reproducibility, risk prediction and monitoring of therapy...
December 26, 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/28011142/cell-matrix-mechanical-interaction-in-electrospun-polymeric-scaffolds-for-tissue-engineering-implications-for-scaffold-design-and-performance
#12
REVIEW
Kelsey M Kennedy, Archana Bhaw-Luximon, Dhanjay Jhurry
: Engineered scaffolds produced by electrospinning of biodegradable polymers offer a 3D, nanofibrous environment with controllable structural, chemical, and mechanical properties that mimic the extracellular matrix of native tissues and have shown promise for a number of tissue engineering applications. The microscale mechanical interactions between cells and electrospun matrices drive cell behaviors including migration and differentiation that are critical to promote tissue regeneration...
December 21, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/28009724/current-opinion-in-alzheimer-s-disease-therapy-by-nanotechnology-based-approaches
#13
Shakeel Ahmed Ansari, Rukhsana Satar, Asma Perveen, Ghulam Md Ashraf
PURPOSE OF REVIEW: Nanotechnology typically deals with the measuring and modeling of matter at nanometer scale by incorporating the fields of engineering and technology. The most prominent feature of these engineered materials involves their manipulation/modification for imparting new functional properties. The current review covers the most recent findings of Alzheimer's disease (AD) therapeutics based on nanoscience and technology. RECENT FINDINGS: Current studies involve the application of nanotechnology in developing novel diagnostic and therapeutic tools for neurological disorders...
December 21, 2016: Current Opinion in Psychiatry
https://www.readbyqxmd.com/read/28007182/recent-progress-of-arsenic-adsorption-on-tio2-in-the-presence-of-coexisting-ions-a-review
#14
REVIEW
Li Yan, Shan Hu, Chuanyong Jing
Arsenic (As)-contaminated wastewater and groundwater pose a pressing environmental issue and worldwide concern. Adsorption of As using TiO2 materials, in combination with filtration, introduces a promising technology for the treatment of As-contaminated water. This review presents an overview on the recent progress of the application of TiO2 for removal of As from wastewater and groundwater. The main focus is on the following three pressing issues that limit the field applications of TiO2 for As removal: coexisting ions, simulation of breakthrough curves, and regeneration and reuse of spent TiO2 materials...
November 2016: Journal of Environmental Sciences (China)
https://www.readbyqxmd.com/read/28005324/co2-capture-in-dry-and-wet-conditions-in-utsa-16-metal-organic-framework
#15
Alessio Masala, Jenny G Vitillo, Giorgia Mondino, Carlos A Grande, Richard Blom, Maela Manzoli, Marc Marshall, Silvia Bordiga
Water is the strongest competitor to CO2 in the adsorption on microporous materials, affecting their performances as CO2 scrubbers in processes such as postcombustion carbon capture. The metal-organic framework (MOF) UTSA-16 is considered a promising material for its capacity to efficiently capture CO2 in large quantities, thanks to the presence of open metal sites (OMSs). It is here shown that UTSA-16 is also able to desorb fully water already at room temperature. This property is unique from all the other materials with OMSs reported so far...
December 22, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28001001/co2-capture-from-ambient-air-by-crystallization-with-a-guanidine-sorbent
#16
Charles A Seipp, Neil J Williams, Michelle K Kidder, Radu Custelcean
Carbon capture and storage is an important strategy for stabilizing the increasing concentration of atmospheric CO2 and the global temperature. A possible approach toward reversing this trend and decreasing the atmospheric CO2 concentration is to remove the CO2 directly from air (direct air capture). Herein we report a simple aqueous guanidine sorbent that captures CO2 from ambient air and binds it as a crystalline carbonate salt by guanidinium hydrogen bonding. The resulting solid has very low aqueous solubility (Ksp =1...
December 21, 2016: Angewandte Chemie
https://www.readbyqxmd.com/read/27995751/3d-bioprinting-for-organ-regeneration
#17
Haitao Cui, Margaret Nowicki, John P Fisher, Lijie Grace Zhang
Regenerative medicine holds the promise of engineering functional tissues or organs to heal or replace abnormal and necrotic tissues/organs, offering hope for filling the gap between organ shortage and transplantation needs. Three-dimensional (3D) bioprinting is evolving into an unparalleled biomanufacturing technology due to its high-integration potential for patient-specific designs, precise and rapid manufacturing capabilities with high resolution, and unprecedented versatility. It enables precise control over multiple compositions, spatial distributions, and architectural accuracy/complexity, therefore achieving effective recapitulation of microstructure, architecture, mechanical properties, and biological functions of target tissues and organs...
December 20, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27995526/chitosan-based-matrices-prepared-by-gamma-irradiation-for-tissue-regeneration-structural-properties-vs-preparation-method
#18
REVIEW
Maria Helena Casimiro, Joana J H Lancastre, Alexandra P Rodrigues, Susana R Gomes, Gabriela Rodrigues, Luís M Ferreira
In the last decade, new generations of biopolymer-based materials have attracted attention, aiming its application as scaffolds for tissue engineering. These engineered three-dimensional scaffolds are designed to improve or replace damaged, missing, or otherwise compromised tissues or organs. Despite the number of promising methods that can be used to generate 3D cell-instructive matrices, the innovative nature of the present work relies on the application of ionizing radiation technology to form and modify surfaces and matrices with advantage over more conventional technologies (room temperature reaction, absence of harmful initiators or solvents, high penetration through the bulk materials, etc...
February 2017: Topics in Current Chemistry (Journal)
https://www.readbyqxmd.com/read/27987680/mediating-bone-regeneration-by-means-of-drug-eluting-implants-from-passive-to-smart-strategies
#19
REVIEW
Sara Bagherifard
In addition to excellent biocompatibility and mechanical performance, the new generation of bone and craniofacial implants are expected to proactively contribute to the regeneration process and dynamically interact with the host tissue. To this end, integration and sustained delivery of therapeutic agents has become a rapidly expanding area. The incorporated active molecules can offer supplementary features including promoting oteoconduction and angiogenesis, impeding bacterial infection and modulating host body reaction...
February 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27973852/calcium-silicate-phases-explained-by-high-temperature-resistant-phosphate-probe-molecules
#20
Nicolas Giraudo, Samuel Bergdolt, Jonas Wohlgemuth, Alexander Welle, Rainer Schuhmann, Franz Königer, Peter Thissen
In this work, high-temperature-resistant phosphate molecules are applied to characterize ultrathin (100 nm) calcium silicate (C-S) phases. These C-S phases are synthesized on silicon wafers, and the interaction of phosphates with the C-S phases is studied by means of in situ transmission Fourier transform infrared (FTIR) spectroscopy. At room temperature, the chemistry of the system is dominated by the formation of calcium phosphates (C-P). In the case of temperature rising to 1000 °C, the C-S phases are regenerated...
December 27, 2016: Langmuir: the ACS Journal of Surfaces and Colloids
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