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https://www.readbyqxmd.com/read/28530097/total-particle-number-emissions-from-modern-diesel-natural-gas-and-hybrid-heavy-duty-vehicles-during-on-road-operation
#1
Tianyang Wang, David Christopher Quiros, Arvind Thiruvengadam, Saroj Pradhan, Shaohua Hu, Tao Huai, Eon S Lee, Yifang Zhu
Particle emissions from heavy-duty vehicles (HDVs) have significant environmental and public health impacts. This study measured total particle number emission factors (PNEFs) from six newly-certified HDVs powered by diesel and compressed natural gas totaling over 6,800 miles of on-road operation in California. Distance-, fuel- and work-based PNEFs were calculated for each vehicle. Distance-based PNEFs of vehicles equipped with original equipment manufacturer (OEM) diesel particulate filters (DPFs) in this study have decreased by 355-3200 times compared to a previous retrofit DPF dynamometer study...
May 22, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28529134/direct-reprogramming-epigenetics-and-cardiac-regeneration
#2
REVIEW
Shota Kurotsu, Takeshi Suzuki, Masaki Ieda
The discovery of induced pluripotent stem cells (iPSCs) has revolutionized regenerative medicine. Autologous iPSCs can be generated by introducing 4 stem cell-specific factors (Oct4, Sox2, Klf4, c-Myc) into fibroblasts. iPSCs can propagate indefinitely and differentiate into clinically important cell types including cardiomyocytes, in vitro. The iPSC-derived cardiomyocytes represent a promising source of cells for cell-based therapeutic approaches for cardiac regeneration. However, there are several challenges in the clinical application of iPSCs: tumorigenicity of immature cells, poor survival of the transplanted myocardial cells, and cost and efficacy of this therapeutic approach...
May 18, 2017: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/28521206/decontamination-of-multiple-heavy-metals-containing-effluents-through-microbial-biotechnology
#3
Minxi Wu, Jingjing Liang, Jie Tang, Guang Li, Shiping Shan, Zhaohui Guo, Le Deng
To decontaminate heavy metal-containing waste water, a microbial biotechnology was developed by using the synergy between Sulfate reducing bacteria (SRB), Bacillus cereus (B. cereus) and Camellia oleifera cake (COC). In this process the COC degradation assisted by B.cereus, created an anoxic environment and provided energy and nutrition for SRB. Both of B. cereus and SRB played significant roles through biosorption, bioaccumulation and biosurfactant production. Meanwhile, a flotation technology commonly used in many effluent treatments has been led into this system for increasing the efficiency as well...
May 5, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28521089/nanoporous-block-polymer-thin-films-functionalized-with-bio-inspired-ligands-for-the-efficient-capture-of-heavy-metal-ions-from-water
#4
Jacob Logan Weidman, Ryan A Mulvenna, Bryan W Boudouris, William A Phillip
Heavy metal contamination of water supplies poses a serious threat to public health, prompting the development of novel and sustainable treatment technologies. One promising approach is to molecularly engineer the chemical affinity of a material for the targeted removal of specific molecules from solution. In this work, nanoporous polymer thin films generated from tailor-made block polymers were functionalized with the bio-inspired moieties glutathione and cysteamine for the removal of heavy metal ions, including lead and cadmium, from aqueous solutions...
May 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28515001/in-vitro-extracellular-matrix-accumulation-of-nasal-and-articular-chondrocytes-for-intervertebral-disc-repair
#5
S Vedicherla, C T Buckley
Chondrocyte based regenerative therapies for intervertebral disc repair such as Autologous Disc Cell Transplantation (ADCT, CODON) and allogeneic juvenile chondrocyte implantation (NuQu(®), ISTO Technologies) have demonstrated good outcomes in clinical trials. However concerns remain with the supply demand reconciliation and issues surrounding immunoreactivity which exist for allogeneic-type technologies. The use of stem cells is challenging due to high growth factor requirements, regulatory barriers and differentiation towards a stable phenotype...
May 8, 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28512850/in-situ-handheld-3d-bioprinting-for-cartilage-regeneration
#6
Claudia Di Bella, Serena Duchi, Cathal D O'Connell, Romane Blanchard, Cheryl Augustine, Zhilian Yue, Fletcher Thompson, Christopher Richards, Stephen Beirne, Carmine Onofrillo, Sebastien H Bauquier, Stewart D Ryan, Peter Pivonka, Gordon G Wallace, Peter F Choong
Articular cartilage injuries experienced at an early age can lead to the development of osteoarthritis later in life. In situ 3D printing is an exciting and innovative bio-fabrication technology that enables the surgeon to deliver tissue- engineering techniques at the time and location of need. We have created a hand- held 3D printing device (Biopen) that allows the simultaneous co-axial extrusion of bioscaffold and cultured cells directly into the cartilage defect in vivo in a single session surgery. This pilot study assesses the ability of the Biopen to repair a full thickness chondral defect and the early outcomes in cartilage regeneration, and compares these results to other treatments in a large animal model...
May 17, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28510305/reactive-precipitation-of-anhydrous-alkali-sulfide-nanocrystals-with-concomitant-abatement-of-hydrogen-sulfide-and-co-generation-of-hydrogen
#7
Yongan Yang, Xuemin Li, Yangzhi Zhao, Alice Brennan, Miranda McCeig, Colin A Wolden
Anhydrous alkali sulfide (M2S, M = Li and Na) nanocrystals (NCs) are important materials central to the development of next generation cathodes and solid state electrolytes for advanced batteries, but not commercially available at present. This work reports an innovative method to directly synthesize M2S-NCs through alcohol-mediated reactions between alkali metals and hydrogen sulfide (H2S). In the first step, the alkali metal is complexed with alcohol in solution, forming metal alkoxide (ROM) and releasing hydrogen (H2)...
May 16, 2017: ChemSusChem
https://www.readbyqxmd.com/read/28507711/interfacial-engineering-of-renewable-metal-organic-framework-derived-honeycomb-like-nanoporous-aluminum-hydroxide-with-tunable-porosity
#8
Ye-Tang Pan, Lu Zhang, Xiaomin Zhao, De-Yi Wang
Novel honeycomb-like mesoporous aluminum hydroxide (pATH) was synthesized via a facile one-step reaction by employing ZIF-8 as a template. This self-decomposing template was removed automatically under acidic conditions without the need for any tedious or hazardous procedures. Meanwhile, the pore size of pATH was easily modulated by tuning the dimensions of the ZIF-8 polyhedrons. Of paramount importance was the fact that the dissolved ZIF-8 in solution was regenerated upon deprotonation of the ligand under mild alkali conditions, and was reused in the preparation of pATH, thus forming a delicate synthesis cycle...
May 1, 2017: Chemical Science
https://www.readbyqxmd.com/read/28504242/simultaneous-microfluidic-spinning-of-multiple-strands-of-submicron-fiber-for-the-production-of-free-standing-porous-membranes-for-biological-application
#9
DoYeun Park, JiSoo Park, Heeyeong Jang, Jie Cheng, Soo-Hyun Kim, Sang-Hoon Lee
Microfibers produced using electrospinning and microfluidics-based technologies have been developed as a powerful tool in tissue engineering applications such as drug delivery and scaffolds. The applications of these fibers, however, have been limited because of the hazardous solvents used to make them, difficulties in controlling the pore sizes of their membrane forms, and downscaling the size of the fiber. Nevertheless, extending the use of these fibers such as the production of a free-standing porous membrane appropriate for cell-based research is highly needed for tissue engineering, organ-on-a-chip, and drug delivery research and applications...
May 15, 2017: Biofabrication
https://www.readbyqxmd.com/read/28503966/topical-use-of-dexpanthenol-a-70th-anniversary-article
#10
Ehrhardt Proksch, Raymond de Bony, Sonja Trapp, Stéphanie Boudon
Approximately 70 years ago, the first topical dexpanthenol-containing formulation (Bepanthen™ Ointment) has been developed. Nowadays, various topical dexpanthenol preparations exist, tailored according to individual requirements. Topical dexpanthenol has emerged as frequently used formulation in the field of dermatology and skin care. Various studies confirmed dexpanthenol's moisturizing and skin barrier enhancing potential. It prevents skin irritation, stimulates skin regeneration and promotes wound healing...
May 14, 2017: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/28503951/gold-nanoparticles-applications-from-artificial-enzyme-till-drug-delivery
#11
Kazem Golchin, Jafar Golchin, Shahrooz Ghaderi, Neda Alidadiani, Sajjad Eslamkhah, Masoud Eslamkhah, Soodabeh Davaran, Abolfazl Akbarzadeh
Today, nano-medicine promotes new therapeutics and diagnostics tools, including sensing of biomolecules as a biosensor, cancer chemotherapy and drug or gene delivery. Because of small size and biocompatibility of gold nanoparticles (GNPs), they become a good candidate for biological application. Also, thanks to their biological and chemical properties, they can mimic function of some enzymes including super oxide dismutase (SOD), esterase, etc. Also, biomaterials and bioengineering have grown so fast since the last decade for many therapeutic applications such as tissue regeneration...
May 14, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28502796/in-vivo-reprogramming-for-heart-regeneration-a-glance-at-efficiency-environmental-impacts-challenges-and-future-directions
#12
REVIEW
Behnam Ebrahimi
Replacing dying or diseased cells of a tissue with new ones that are converted from patient's own cells is an attractive strategy in regenerative medicine. In vivo reprogramming is a novel strategy that can circumvent the hurdles of autologous/allogeneic cell injection therapies. Interestingly, studies have demonstrated that direct injection of cardiac transcription factors or specific miRNAs into the infarct border zone of murine hearts following myocardial infarction converts resident cardiac fibroblasts into functional cardiomyocytes...
May 11, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28500409/physicochemical-and-biological-characteristics-of-bmp-2-igf-1-loaded-three-dimensional-coaxial-electrospun-fibrous-membranes-for-bone-defect-repair
#13
Lihua Yin, Shaohua Yang, Miaomiao He, Yuchen Chang, Kaijuan Wang, Yidan Zhu, Yuhui Liu, Yaoren Chang, Zhanhai Yu
Coaxial electrospun fibrous membranes show favorable mechanical properties for use in guided bone regeneration (GBR). We used coaxial electrospinning technology to fabricate three-dimensional nanofiber membranes loaded with BMP-2 and IGF-1, and assessed the physicochemical and biological properties of these novel membranes in vitro. We fabricated four experimental groups of BMP-2/IGF-1/BSA-loaded membranes with different flow ratios (shell/core). Membrane characteristics were assessed by scanning and transmission electron microscopy, and laser confocal microscopy...
June 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28499298/-cochlear-implant-state-of-the-art
#14
Thomas Lenarz
Cochlear implants are the treatment of choice for the auditory rehabilitation of patients with sensory deafness. They restore the missing function of inner hair cells by transforming the acoustic signal into electrical stimuli for activation of auditory nerve fibers. Due to the very fast technology development cochlear implants provide open-set speech understanding in the majority of patients including the use of the telephone. Children can achieve a near to normal speech and language development provided their deafness is detected early after onset and implantation is performed quickly thereafter...
April 2017: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/28496103/in-situ-printing-of-mesenchymal-stromal-cells-by-laser-assisted-bioprinting-for-in-vivo-bone-regeneration-applications
#15
Virginie Keriquel, Hugo Oliveira, Murielle Rémy, Sophia Ziane, Samantha Delmond, Benoit Rousseau, Sylvie Rey, Sylvain Catros, Joelle Amédée, Fabien Guillemot, Jean-Christophe Fricain
Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in the field of tissue engineering. We have recently shown that Laser Assisted Bioprinting (LAB), due to its unprecedented cell printing resolution and precision, is an attractive tool for the in situ printing of a bone substitute. Here, we show that LAB can be used for the in situ printing of mesenchymal stromal cells, associated with collagen and nano-hydroxyapatite, in order to favor bone regeneration, in a calvaria defect model in mice...
May 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28494717/gelatin-as-biomaterial-for-tissue-engineering
#16
Mari Carmen Echave, Laura Saenz Del Burgo, Jose Luis Pedraz, Gorka Orive
Tissue engineering is considered one of the most important therapeutic strategies of regenerative medicine. The main objective of these new technologies is the development of substitutes made with biomaterials that are able to heal, repair or regenerate injured or diseased tissues and organs. These constructs seek to unlock the limited ability of human tissues and organs to regenerate. In this review, we highlight the convenient intrinsic properties of gelatin for the design and development of advanced systems for tissue engineering...
May 11, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28492684/oxidative-remediation-of-4-methylcyclohexanemethanol-mchm-and-propylene-glycol-phenyl-ether-pph-evidence-of-contaminant-repair-reaction-pathways
#17
Cen Zhao, Julie R Peller, Stephen P Mezyk, Prashant V Kamat, Kevin E O'Shea
A large spill of 4-methylcyclohexanemethanol (MCHM) and propylene glycol phenyl ether (PPh) into the Elk River near Charleston, West Virginia on January 9, 2014 led to serious water contamination and public concerns about appropriate remediation. To assess the feasibility of advanced oxidation processes (AOPs) for remediation of waters contaminated with these compounds, we induced hydroxyl radical (HO˙) reactions using time-resolved and steady-state radiolysis methods. Detailed product analyses showed initial HO˙ attack was at the benzene ring of PPh, and occurred through H-atom abstraction reactions for MCHM...
May 11, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28492016/vaginal-rejuvenation-using-energy-based-devices
#18
REVIEW
Cheryl Karcher, Neil Sadick
Physiologic changes in a woman's life, such as childbirth, weight fluctuations, and hormonal changes due to aging and menopause, may alter the laxity of the vaginal canal, damage the pelvic floor, and devitalize the mucosal tone of the vaginal wall. These events often lead to the development of genitourinary conditions such as stress urinary incontinence; vaginal atrophy; dryness; and physiologic distress affecting a woman's quality of life, self-confidence, and sexuality. Various treatment modalities are currently available to manage these indications, varying from invasive vaginal surgery to more benign treatments like topical vaginal hormonal gels or hormone-replacement therapy...
September 2016: International Journal of Women's Dermatology
https://www.readbyqxmd.com/read/28491274/biomimetic-strategies-for-fracture-repair-engineering-the-cell-microenvironment-for-directed-tissue-formation
#19
Wollis J Vas, Mittal Shah, Rawiya Al Hosni, Helen C Owen, Scott J Roberts
Complications resulting from impaired fracture healing have major clinical implications on fracture management strategies. Novel concepts taken from developmental biology have driven research strategies towards the elaboration of regenerative approaches that can truly harness the complex cellular events involved in tissue formation and repair. Advances in polymer technology and a better understanding of naturally derived scaffolds have given rise to novel biomaterials with an increasing ability to recapitulate native tissue environments...
January 2017: Journal of Tissue Engineering
https://www.readbyqxmd.com/read/28484675/plants-from-the-abandoned-nacozari-mine-tailings-evaluation-of-their-phytostabilization-potential
#20
Alina E Santos, Rocio Cruz-Ortega, Diana Meza-Figueroa, Francisco M Romero, Jose Jesus Sanchez-Escalante, Raina M Maier, Julia W Neilson, Luis David Alcaraz, Francisco E Molina Freaner
Phytostabilization is a remediation technology that uses plants for in-situ stabilization of contamination in soils and mine tailings. The objective of this study was to identify native plant species with potential for phytostabilization of the abandoned mine tailings in Nacozari, Sonora in northern Mexico. A flora of 42 species in 16 families of angiosperms was recorded on the tailings site and the abundance of the most common perennial species was estimated. Four of the five abundant perennial species showed evidence of regeneration: the ability to reproduce and establish new seedlings...
2017: PeerJ
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