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Alcohol and addiction

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https://www.readbyqxmd.com/read/28930061/promoting-adoption-of-medication-for-opioid-and-alcohol-use-disorders-through-system-change
#1
James H Ford, Amanda J Abraham, Nicoleta Lupulescu-Mann, Raina Croff, Kim A Hoffman, Kelly Alanis-Hirsch, Mady Chalk, Laura Schmidt, Dennis McCarty
OBJECTIVE: The Medication Research Partnership (MRP), a collaboration between a national commercial health plan and nine addiction treatment centers, implemented organizational and system changes to promote use of federally approved medications for treatment of alcohol and opioid use disorders. METHOD: A difference-in-differences analysis examined change over time in the percentage of patients receiving a prescription medication for alcohol or opioid use disorders treated in MRP (n = 9) and comparison (n = 15) sites...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28930052/portrayal-of-alcohol-brands-popular-among-underage-youth-on-youtube-a-content-analysis
#2
Brian A Primack, Jason B Colditz, Eva B Rosen, Leila M Giles, Kristina M Jackson, Kevin L Kraemer
OBJECTIVE: We characterized leading YouTube videos featuring alcohol brand references and examined video characteristics associated with each brand and video category. METHOD: We systematically captured the 137 most relevant and popular videos on YouTube portraying alcohol brands that are popular among underage youth. We used an iterative process to codebook development. We coded variables within domains of video type, character sociodemographics, production quality, and negative and positive associations with alcohol use...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28930051/addiction-and-the-role-of-circadian-genes
#3
Laura A Forde, Gursharan Kalsi
OBJECTIVE: In mammals, intimate interactions exist between the circadian system and other molecular systems, and mounting evidence is suggesting that these relationships may affect substance use disorders. Research in preclinical models supports the role of circadian genes as risk factors for addiction. Here, we explore the evidence and review human genetic studies testing the association between specific circadian genes and substance use disorders. METHOD: A literature search was conducted in PubMed for studies testing variants in eight circadian genes known to be central to the functioning of the master clock in the brain...
September 2017: Journal of Studies on Alcohol and Drugs
https://www.readbyqxmd.com/read/28928305/awakening-to-the-alcohol-epidemic-need-of-the-hour
#4
Dharav Sunil Shah
Globally, alcohol has become the most common risk factor for death and disability in the young age group of 15-49 years. Its use has been rapidly increasing in developing countries. It is a critical time wherein if effective preventive measures are not undertaken urgently, damage done will be difficult to reverse. However, health professionals are not responding to the alcohol epidemic in the manner that they responded to the tobacco epidemic. The article discusses two beliefs which are making us accept the use of alcohol as normal...
July 2017: Indian Journal of Public Health
https://www.readbyqxmd.com/read/28926776/the-impact-of-price-policy-on-demand-for-alcohol-in-rural-india
#5
Arjunan Subramanian, Parmod Kumar
Whether raising the price of addictive goods can reduce its burden is widely debated in many countries, largely due to lack of appropriate data and robust methods. Three key concerns frequently raised in the literature are: unobserved heterogeneity; omitted variables; identification problem. Addressing these concerns, using robust instrument and employing unique individual-level panel data from Indian Punjab, this paper investigates two related propositions (i) will increase in alcohol price reduce its burden (ii) since greater incomes raise the costs of inebriation, will higher incomes affect consumption of alcohol negatively...
August 24, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28921935/assessing-causal-relationships-using-genetic-proxies-for-exposures-an-introduction-to-mendelian-randomisation
#6
Srinivasa Vittal Katikireddi, Michael Green, Amy E Taylor, George Davey Smith, Marcus R Munafò
BACKGROUND AND AIMS: Studying the consequences of addictive behaviours is challenging, with understanding causal relationships from observational data being particularly difficult. For example, people who smoke or drink excessively are often systematically different from those who do not, are less likely to participate in research, and may misreport their behaviours when they do. Furthermore, the direction of causation between an addictive behaviour and outcome may be unclear. Mendelian randomisation (MR) offers potential solutions to these problems...
September 18, 2017: Addiction
https://www.readbyqxmd.com/read/28921667/polysubstance-use-among-adolescents-in-a-low-income-rural-community-latent-classes-for-middle-and-high-school-students
#7
Roderick A Rose, Caroline B R Evans, Paul R Smokowski, Matthew O Howard, Katie L Stalker
PURPOSE: Rural communities are currently being impacted by a nationwide epidemic of prescription opioid misuse. Rural adolescent substance users may be at substantial risk for later addiction to these and other drugs. METHODS: This study uses Latent Class Analysis to identify subtypes of polysubstance users among a sample of 7,074 rural adolescents. Separate models were estimated for middle- and high-school youth. Predictive validity was estimated using cumulative ordinal logistic regression of the classes on a set of youth and family characteristics...
September 18, 2017: Journal of Rural Health
https://www.readbyqxmd.com/read/28919445/cognitive-effects-of-labeled-addictolytic-medications
#8
REVIEW
Camille Noélie Pujol, Cecilia Paasche, Vincent Laprevote, Benoit Trojak, Pierre Vidailhet, Elisabeth Bacon, Laurence Lalanne
INTRODUCTION: Alcohol, tobacco, and illegal drug usage is pervasive throughout the world, and abuse of these substances is a major contributor to the global disease burden. Many pharmacotherapies have been developed over the last 50years to target addictive disorders. While the efficacy of these pharmacotherapies is largely recognized, their cognitive impact is less known. However, all substance abuse disorders are known to promote cognitive disorders like executive dysfunction and memory impairment...
September 14, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28918416/-the-methodology-and-sample-description-of-the-national-survey-on-addiction-problems-in-hungary-2015-nsaph-2015
#9
Borbala Paksi, Zsolt Demetrovics, Anna Magi, Katalin Felvinczi
This paper introduces the methods and methodological findings of the National Survey on Addiction Problems in Hungary (NSAPH 2015). Use patterns of smoking, alcohol use and other psychoactive substances were measured as well as that of certain behavioural addictions (problematic gambling - PGSI, DSM-V, eating disorders - SCOFF, problematic internet use - PIUQ, problematic on-line gaming - POGO, problematic social media use - FAS, exercise addictions - EAI-HU, work addiction - BWAS, compulsive buying - CBS)...
June 2017: Neuropsychopharmacologia Hungarica
https://www.readbyqxmd.com/read/28901327/selective-lesioning-of-nuclear-factor-kb-activated-cells-in-the-nucleus-accumbens-shell-attenuates-alcohol-place-preference
#10
S E Nennig, H D Fulenwider, S H Chimberoff, B M Smith, J E Eskew, M K Sequeira, C Karlsson, C Liang, J Chen, M Heilig, J R Schank
Nuclear factor κ light chain enhancer of activated B cells (NFkB) is a transcription factor commonly associated with innate immunity, and is activated by infection and inflammation. NFkB has recently gained attention as a mediator of complex psychiatric phenomena like stress and addiction. In regards to alcohol, most research on NFkB has focused on neurotoxicity, and few studies have explored the role of NFkB in alcohol reward, reinforcement, or consumption. In these studies, we used conditioned place preference to assess the activity of NFkB in response to rewarding doses of alcohol...
September 13, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28895569/the-effects-of-the-monoamine-stabilizer-osu6162-on-binge-like-eating-and-cue-controlled-food-seeking-behavior-in-rats
#11
K Feltmann, C Giuliano, B J Everitt, P Steensland, J Alsiö
Binge eating disorder (BED) is characterized by recurring episodes of excessive consumption of palatable food and an increased sensitivity to food cues. Patients with BED display an addiction-like symptomatology and the dopamine system might be a potential treatment target. The clinically safe monoamine stabilizer (-)-OSU6162 (OSU6162) restores dopaminergic dysfunction in long-term alcohol drinking rats and shows promise as a novel treatment for alcohol use disorder. Here, the effects of OSU6162 on consummatory (binge-like eating) and appetitive (cue-controlled seeking) behavior motivated by chocolate-flavored sucrose pellets were evaluated in non-food-restricted male Lister Hooded rats...
September 12, 2017: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/28893411/suicidal-thoughts-in-persons-treated-for-alcohol-dependence-the-role-of-selected-demographic-and-clinical-factors
#12
Marcin Ziółkowski, Damian Czarnecki, Jan Chodkiewicz, Krzysztof Gąsior, Artur Juczyński, Agata Biedrzycka, Ewa Gruszczyńska, Katarzyna Nowakowska-Domagała
Greater knowledge is needed of potential predictive factors for suicide in cases of alcohol addiction. Therefore, the aim of the study was to identify the socio-demographic variables and clinical factors associated with alcohol dependence which may have an influence on the occurrence of suicidal thoughts in alcohol-dependent patients. A group of 510 patients (396 male and 114 female) diagnosed with alcohol dependence syndrome were interviewed during the third week of therapy according to the Beck Depression Inventory (BDI), the Penn Alcohol Craving Scale (PACS) and the Short Alcohol Dependence Data Questionnaire (SADD)...
September 1, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28892072/neuregulin-signaling-pathway-in-smoking-behavior
#13
R Gupta, B Qaiser, L He, T S Hiekkalinna, A B Zheutlin, S Therman, M Ollikainen, S Ripatti, M Perola, V Salomaa, L Milani, T D Cannon, P A F Madden, T Korhonen, J Kaprio, A Loukola
Understanding molecular processes that link comorbid traits such as addictions and mental disorders can provide novel therapeutic targets. Neuregulin signaling pathway (NSP) has previously been implicated in schizophrenia, a neurodevelopmental disorder with high comorbidity to smoking. Using a Finnish twin family sample, we have previously detected association between nicotine dependence and ERBB4 (a neuregulin receptor), and linkage for smoking initiation at the ERBB4 locus on 2q33. Further, Neuregulin3 has recently been shown to associate with nicotine withdrawal in a behavioral mouse model...
August 22, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28890649/recent-alcohol-tobacco-and-substance-use-variations-between-rural-and-urban-middle-and-high-school-students
#14
Jacob C Warren, K Bryant Smalley, K Nikki Barefoot
The use of addictive substances by adolescents is a major public health concern; however, rural vs. urban variations are poorly understood. The purpose of the current study was to examine rural-urban differences in the prevalence of recent use of 11 substances in grades 6-12 in a statewide sample of students from the Georgia Student Health Survey II (n = 513,909). We found that rural-urban differences in substance use depend largely upon grade level, with rural middle school students demonstrating higher rates of alcohol, smoking tobacco, and chewing tobacco use, and urban high school students demonstrating higher rates of illicit drugs...
2017: Journal of Child & Adolescent Substance Abuse
https://www.readbyqxmd.com/read/28889008/the-interplay-between-ventro-striatal-bdnf-levels-and-the-effects-of-valproic-acid-on-the-acquisition-of-ethanol-induced-conditioned-place-preference-in-mice
#15
Manuel Alves Dos Santos, Sarah Sousa Escudeiro, Germana Silva Vasconcelos, Natália Castelo Branco Matos, Marcos Romário Matos de Souza, Manoel Cláudio Azevedo Patrocínio, Leonardo Pimentel Dantas, Danielle Macêdo, Silvânia Maria Mendes Vasconcelos
Alcohol addiction is a chronic, relapsing and progressive brain disease with serious consequences for health. Compulsive use of alcohol is associated with the capacity to change brain structures involved with the reward pathway, such as ventral striatum. Recent evidence suggests a role of chromatin remodeling in the pathophysiology of alcohol dependence and addictive-like behaviors. In addition, neuroadaptive changes mediated by the brain-derived neurotrophic factor (BDNF) seems to be an interesting pharmacological target for alcoholism treatment...
September 6, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28886172/use-of-alcohol-and-drugs-with-addiction-potential-among-older-women-and-men-in-a-population-based-study-the-nord-tr%C3%A3-ndelag-health-study-2006-2008-hunt3
#16
Kjerstin Tevik, Geir Selbæk, Knut Engedal, Arnfinn Seim, Steinar Krokstad, Anne-S Helvik
BACKGROUND: Little is known about the consumption habits of older adults in Norway with respect to alcohol and the use of drugs with addiction potential, such as benzodiazepines, z-hypnotics and opioids, among regular drinkers. We studied the prevalence of self-reported consumption of alcohol on a regular basis in community-living older men and women (≥ 65 years). Furthermore, we investigated the prevalence of dispensed prescribed drugs with addiction potential in older men and women who were regular drinkers...
2017: PloS One
https://www.readbyqxmd.com/read/28885301/perceptions-of-neighborhood-mediate-the-relationship-between-ptsd-symptoms-and-coping-in-a-neighborhood-matched-substance-using-sample
#17
Sara K Hertzel, Jennifer Schroeder, Landhing M Moran, Anika A Alvanzo, William J Kowalczyk, David H Epstein, Kenzie L Preston, Karran A Phillips
OBJECTIVES: People with substance use problems living in neighborhoods with high levels of disorder are disproportionately likely to experience trauma and develop PTSD symptoms. We sought to evaluate the relationships between objective neighborhood disorder, perceptions of neighborhood, and the use of maladaptive coping behaviors among both non-substance-using and substance-using participants with and without PTSD symptoms. METHODS: Participants (255 non-drug users [NDUs], 168 marijuana and/or alcohol users [MAUs], and 273 opioid and/or stimulant users) completed the Addiction Severity Index, PTSD Checklist-Civilian Version, The COPE Inventory, and the Perceived Neighborhood Scale...
September 6, 2017: Journal of Addiction Medicine
https://www.readbyqxmd.com/read/28880351/-refeeding-syndrome-during-alcohol-detoxification
#18
J J S Rutten, H Post, G H de Weert-van Oene, V J A Buwalda
Refeeding syndrome (RS) can occur when malnourished patients are reintroduced to carbohydrates. The symptoms are caused by a combination of electrolyte shifts and fluid retention. Symptoms are wide-ranging; some patients may suffer from harmless muscle cramps, others from more severe neurological and cardiological symptoms that can even lead to death. Although alcohol dependence is a risk factor for the development of RS, little attention is being given to this problem in addiction treatment. In this article we report a case of RS that occurred during alcohol detoxification...
2017: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/28876377/crack-cocaine-users-have-less-family-cohesion-than-alcohol-users
#19
Nino C Marchi, Juliana N Scherer, Mayra P Pachado, Luciano S Guimarães, Gerson Siegmund, Melina N de Castro, Silvia Halpern, Daniela Benzano, Maria L Formigoni, Marcelo Cruz, Flavio Pechansky, Felix H Kessler
Objective: Many studies correlate characteristics of family functioning and the development of drug addiction. This study sought to evaluate and compare the family environment styles of two groups of psychoactive substance users: 1) alcohol-only users and 2) crack-cocaine users. Methods: Three hundred and sixty-four users of alcohol, crack-cocaine, and other drugs, recruited from research centers in four Brazilian capitals participated in this study. Subjects were evaluated through the Family Environment Scale and the Addiction Severity Index, 6th version (ASI-6)...
August 30, 2017: Revista Brasileira de Psiquiatria
https://www.readbyqxmd.com/read/28868159/the-effects-of-residential-dual-diagnosis-treatment-on-alcohol-abuse
#20
Stephen J Schoenthaler, Kenneth Blum, Lyle Fried, Marlene Oscar-Berman, John Giordano, Edward J Modestino, Rajendra Badgaiyan
This multi-center study of dual diagnosis (DD) programs involved 804 residential patients with co-occurring alcohol and mental health disorders. The Addiction Severity Index was administered at admission and at one, six, and 12 months after discharge. Repeated measures analysis showed the intoxication rate per month stabilized between months six and 12 with 68% still in remission and an 88% mean reduction from baseline (F = 519, p < .005). A comparison between patients with and without weekly relapse produced significant differences in hospitalization (odds ratio 11...
July 2017: Journal of Systems and Integrative Neuroscience
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