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Michihiro Ichimanda, Naoki Hijiya, Yoshiyuki Tsukamoto, Tomohisa Uchida, Chisato Nakada, Tomonori Akagi, Tsuyoshi Etoh, Hidekatsu Iha, Masafumi Inomata, Mutsuhiro Takekawa, Masatsugu Moriyama
It is widely accepted that aberrant activation of the Wnt signaling pathway is responsible for the development of precursor lesions of colorectal cancer (CRC). However, the molecular mechanisms involved in the process of progression from these precursor lesions to invasive lesions of CRC are not fully understood. Recently, we reported that constitutive activation of MAPK accompanied by downregulation of dual-specificity phosphatase 4 (DUSP4), a MAPK phosphatase, contributes to the progression of precursor lesions in the pancreas...
November 18, 2017: Cancer Science
N Mittal, N Thakore, R L Bell, W T Maddox, T Schallert, C L Duvauchelle
Ultrasonic vocalizations (USVs) have been established as an animal model of emotional status and are often utilized in drug abuse studies as motivational and emotional indices. Further USV functionality has been demonstrated in our recent work showing accurate identification of selectively-bred high versus low alcohol-consuming male rats ascertained exclusively from 22 to 28kHz and 50-55kHz FM USV acoustic parameters. With the hypothesis that alcohol-sensitive sex differences could be revealed through USV acoustic parameters, the present study examined USVs and alcohol consumption in male and female selectively bred high-alcohol drinking (HAD-1) rats...
November 13, 2017: Physiology & Behavior
Jonathan H Lindsay, Rebecca A Prosser
BACKGROUND: Alcohol tolerance and withdrawal-induced effects are criteria for alcohol use disorders listed by the DSM-V. Although tolerance and withdrawal have been studied over many decades, there is still uncertainty regarding mechanistic distinctions that characterize these different forms of ethanol (EtOH)-induced plasticity. Previously, we demonstrated that the suprachiasmatic nucleus (SCN) circadian clock develops both acute and rapid tolerance to EtOH inhibition of glutamate-induced circadian phase shifts...
November 15, 2017: Alcoholism, Clinical and Experimental Research
Puthanpura Sasidharan Sreeja, Karuppusamy Arunachalam, Sathyanarayanan Saikumar, Muniyandi Kasipandi, Sivaraj Dhivya, Rajan Murugan, Thangaraj Parimelazhagan
Sphenodesme involucrata var. paniculata (C. B. Clarke) Munir, endemic to South Asia, is used by tribal for alleviation from abdominal disorders, inflammation and body pain. However, the gastroprotective properties of this species have not yet been studied. The leaves of S. involucrata were extracted by Soxhlet extraction using different solvents successively and the extracts were analyzed for antioxidant and anti-Helicobacter pylori activities using different in vitro assays. The chemical composition of methanol extract of S...
November 9, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Hajime Fujishima, Shoichi Fumoto, Tomotaka Shibata, Kohei Nishiki, Yoshiyuki Tsukamoto, Tsuyoshi Etoh, Masatsugu Moriyama, Norio Shiraishi, Masafumi Inomata
BACKGROUND: Recently, neoadjuvant chemotherapy with docetaxel/cisplatin/5-fluorouracil (NAC-DCF) was identified as a novel strong regimen with a high rate of pathological complete response (pCR) in advanced esophageal cancer in Japan. Predicting pCR will contribute to the therapeutic strategy and the prevention of surgical invasion. However, a predictor of pCR after NAC-DCF has not yet been developed. The aim of this study was to identify a novel predictor of pCR in locally advanced esophageal cancer treated with NAC-DCF...
2017: PloS One
Juan Liu, Cheng Peng, Qin-Mei Zhou, Li Guo, Zhao-Hua Liu, Liang Xiong
The crude extract and some Chinese patented medicines of Leonurus japonicus Houtt. have been proven to affect the uterine smooth muscle. L. japonicus injection is widely used in obstetric departments in China for treating postpartum hemorrhage caused by uterine inertia. Bioassay-guided isolation of the 95% EtOH extract of L. japonicus yielded four cyclopeptides, nine alkaloids, and three flavonoid glycosides, including two previously undescribed cyclopeptides, namely, cycloleonuripeptide G and cycloleonuripeptide H...
November 8, 2017: Phytochemistry
Sora Choi, Prince Neequaye, Samuel W French, Frank J Gonzalez, Maxwell A Gyamfi
The pregnane X receptor (PXR, NR1I2) is a xenobiotic-sensing nuclear receptor that modulates the metabolic response to drugs and toxic agents. Both PXR activation and deficiency promote hepatic triglyceride accumulation, a hallmark feature of alcoholic liver disease (ALD). However, the molecular mechanism of PXR-mediated activation of ethanol (EtOH)-induced steatosis is unclear. Here, using male wild type (WT) and Pxr-null mice we examined PXR-mediated regulation of chronic EtOH-induced hepatic lipid accumulation and hepatotoxicity...
November 9, 2017: Journal of Biological Chemistry
Takeharu Ono, Norimitsu Tanaka, Hirohito Umeno, Shun-Ichi Chitose, Buichiro Shin, Takeichiro Aso, Koutaro On, Chikayuki Hattori, Hidehiro Etoh, Tatsuyuki Kakuma, Toshi Abe
BACKGROUND: This study clarified the clinical results of locally advanced squamous cell carcinoma of the maxillary sinus (SCC-MS) that was treated with chemoradioselection using superselective intra-arterial cisplatin and concomitant radiation (RADPLAT). Prognostic factors were also investigated. METHODS: We retrospectively analyzed 63 locally advanced SCC-MS patients treated with initial RADPLAT followed by sequential RADPLAT (S-RADPLAT) or surgery. RESULTS: The 5-year progression-free survival (PFS) and overall survival (OS) rates of patients with T3, T4a, or T4b disease were 72...
October 12, 2017: Journal of Cranio-maxillo-facial Surgery
Hongyan Li, Ming Xiu, Shuhua Wang, David R Brigstock, Li Sun, Limei Qu, Runping Gao
BACKGROUND: Pancreatic fibrosis is a key pathological feature of alcoholic chronic pancreatitis (ACP). Bacterial endotoxin lipopolysaccharide (LPS) is considered as an important cofactor in the fibrogenesis of ACP. However, there are limitations in the use of exogenous LPS for evaluating the role of endotoxin in ACP pathogenesis. In this study we determined the relationship between the concentration of LPS in the portal vein and pancreatic type I collagen (Col1) content in chronic alcohol-fed rats...
November 9, 2017: Alcoholism, Clinical and Experimental Research
Josep Bonjoch, Ben Bradshaw, Mar Saladrigas, Caroline Bosch, Gisela V Saborit
An unprecedented hydrogen atom transfer-based C-C coupling reaction between alkenes and ketones using Fe(acac)3 and PhSiH3 in EtOH is described. This mild protocol features high site-selectivity and allows for the construction of sterically congested structures containing tertiary alcohols and quaternary centers. The overall process introduces a novel strategic bond disconnection for ring-closing reactions.
November 8, 2017: Angewandte Chemie
E J Evans, H Li, Wen-Yueh Yu, G M Mullen, G Henkelman, C Buddie Mullins
In this study, we have combined ultra-high vacuum (UHV) experiments and density functional theory (DFT) calculations to investigate ethanol (EtOH) dehydrogenation on Pd-Au model catalysts. Using EtOH reactive molecular beam scattering (RMBS), EtOH temperature-programmed desorption (TPD), and DFT calculations, we show how different Pd ensemble sizes on Au(111) can affect the mechanism for EtOH dehydrogenation and H2 production. The Au(111) surface with an initial coverage of 2 monolayers of Pd (2 ML Pd-Au) had the highest H2 yield...
November 8, 2017: Physical Chemistry Chemical Physics: PCCP
Xia Chen, Wei Sun, Yinjuan Bai, Feifei Zhang, Junxia Zhao, Xiaohu Ding
Three rhodamine schiff-base type fluorescent sensors R1-R3 for detecting iron ion (Fe(3+)), 2-furanacrolein rhodamine hydrazone (R1), furfural rhodamine hydrazone (R2) and 2-furanacrolein rhodamine ethylenediamine (R3) have been synthesized by using rhodamine B derivatives and furan derivatives as staring materials. And their recognition abilities for Fe(3+) were studied by fluorescence spectroscopy. The result showed that R1 is a best selective probe for Fe(3+) over other metal ions in EtOH/H2O (1:1, v/v) due to having 2-furanacrolein for unique space coordination structural...
October 11, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Mai E Oguchi, Kan Etoh, Mitsunori Fukuda
The Rab family small GTPases are key players in the membrane traffic that underlies various cellular phenomena. Neurite outgrowth, which is a prerequisite for neuronal network formation, also requires membrane traffic from the cell body to the tips of neurites. Although several Rabs have been shown to promote neurite outgrowth, very little is known about Rab involvement in the negative regulation of neurite outgrowth. Here we used nerve growth factor-stimulated PC12 cells to perform siRNA-based comprehensive knockdown screenings for Rabs that negatively regulate neurite outgrowth and succeeded in identifying Rab20 as a novel negative regulator of neurite outgrowth...
October 28, 2017: Neuroscience Letters
Niamh M Murray, Dolores O'Riordan, Jean-Christophe Jacquier, Michael O'Sullivan, Joshua L Cohen, Hildegarde Heymann, Daniela Barile, David C Dallas
Casein-hydrolysates (NaCaH) are desirable functional ingredients, but their bitterness impedes usage in foods. This study sought to validate a paper-disk approach to help evaluate bitterness in NaCaHs and to develop a food-grade approach to separate a NaCaH into distinct fractions, which could be evaluated by a sensory panel. Membrane filtration generated <0.2-μm and <3-kDa permeates. Further fractionation of the <3-kDa permeate by flash-chromatography generated four fractions using ethanol (EtOH) concentrations of 5, 10, 30 and 50%...
June 2017: Journal of Sensory Studies
Wipada Samprasit, Prasert Akkaramongkolporn, Ruchadaporn Kaomongkolgit, Praneet Opanasopit
This work deals with fast-dissolving drug delivery systems of meloxicam (MX) derived from electrospun polyvinylpyrrolidone (PVP)/2-hydroxypropyl-β-cyclodextrin (HPβCD) nanofiber mats. Electrospinning of solutions with different solvent systems (dimethylformamide (DMF) and ethyl alcohol (EtOH)) was performed. Prepared films were evaluated for morphology, physical and mechanical properties. MX content, dissolving time, MX release, and cytotoxicity of films were investigated. In vivo studies were also performed in healthy human volunteers...
November 6, 2017: Pharmaceutical Development and Technology
Michael C Salling, Christopher J Hodge, Kelly E Psilos, Vallari R Eastman, Sara P Faccidomo, Clyde W Hodge
Cue-induced reinstatement of alcohol-seeking is a hallmark behavioral pathology of addiction. Evidence suggests that reinstatement (e.g., relapse), may be regulated by cell signaling systems that underlie neuroplasticity. A variety of plasticity events require activation of calcium calmodulin-dependent protein kinase II (CaMKII) in components of the reward pathway, such as the nucleus accumbens and amygdala. We sought to determine if cue-induced reinstatement of alcohol-seeking behavior is associated with changes in the activation state (e...
October 31, 2017: Pharmacology, Biochemistry, and Behavior
Jun Kawase, Hiroshi Asakura, Morito Kurosaki, Hitoshi Oshiro, Yoshiki Etoh, Tetsuya Ikeda, Masanori Watahiki, Mitsuhiro Kameyama, Fumi Hayashi, Yuta Kawakami, Yoshiko Murakami, Yoshie Tsunomori
  We previously developed a multiplex real-time PCR assay (Rapid Foodborne Bacterial Screening 24 ver.5, RFBS24 ver.5) for simultaneous detection of 24 foodborne bacterial targets. Here, to overcome the discrepancy of the RFBS24 ver.5 and bacterial culture method (BC) results, we analyzed 246 human clinical samples from 49 gastroenteritis outbreaks by the RFBS24 ver.5 and evaluated the correlation between cycle threshold value (CT) of RFBS24 ver.5 and the BC results. The results showed that the RFBS24 ver...
October 31, 2017: Japanese Journal of Infectious Diseases
Massara Mzid, Zohra Ghlissi, Maryem Ben Salem, Sameh Ben Khedir, Khansa Chaabouni, Fatma Ayedi, Zouheir Sahnoun, Ahmed Hakim, Tarek Rebai
Imidacloprid (IMI) is a widely used in Tunisia and abroad, and high doses of IMI have been known to cause endocrine disruption. Some reports claim that Urtica urens L. (UU) can reduce toxicity thanks to it anti-inflammatory and antioxidant activities, but there is no scientific evidence justifying its use, which lets us think to its direct effect on the metabolism of the ovarian tissue. The present study was undertaken to evaluate the protective effect of UU against the toxicity of Confidor(®), whose active substance is imidacloprid (IMI), in female rat, as well as the chemical compositions of UU ethanol (EtOH) extract by GC-MS...
October 28, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
Yue-Mei Chen, Nan-Kai Cao, Peng-Fei Tu, Yong Jiang
The open silica gel, ODS, and Sephadex LH-20 column chromatography, along with the semi-preparative HPLC was used to isolate and purify the chemical constituents from Murraya euchrestifolia. The structures of the isolates were elucidated by their physiochemical properties, NMR, and MS spectroscopic data, as well as comparison with literature data. Eighteen compounds were isolated from the CH2Cl2 fraction of the 95% aqueous EtOH extract of M. euchrestifolia, and their structures were identified as sakuranetin (1), eriodictyol-7,4'-dimethyl ether (2), isosakuranetin (3), 5-hydroxy-7,4'-dimethoxyflavanone (4), eriodictyol-7-methyl ether (5), lichexanthon (6), 5,6,7-trimethoxycoumarin (7), 5-hydroxy-6,8-dimethoxycoumarin (8), 8-hydroxy-6-methoxy-3-n-pentylisocoumarin (9), ethyl caffeate (10), 4-hydroxy-3,5- dimethoxycinnamic acid ethyl ester (11), methyl 3-(5'-hydroxyprenyl)-coumarate (12), (E)-coniferol (13), β-hydroxypropiovanillone (14), 3-hydroxy-7,8-didehydro-β-ionone (15), 3β-hydroxy-5α, 6α-epoxy-7-megastigmen-9-one (16), grasshopper ketone (17), and 4-hydroxy-3,5-dimethoxybenzaldehyde (18)...
May 2017: Zhongguo Zhong Yao za Zhi, Zhongguo Zhongyao Zazhi, China Journal of Chinese Materia Medica
Emelie M Gardebjer, James S M Cuffe, Leigh C Ward, Sarah Steane, Stephen T Anderson, Emily S Dorey, Jacinta I Kalisch-Smith, Marie Pantaleon, Suyinn Chong, Lisa Yamada, Mary E Wlodek, Helle Bielefeldt-Ohmann, Karen M Moritz
The effects of maternal alcohol consumption around the time of conception on offspring are largely unknown and difficult to determine in a human population. This study utilized a rodent model to examine if periconceptional alcohol (PC:EtOH), alone or in combination with a postnatal high-fat diet (HFD) resulted in obesity and liver dysfunction. Sprague-Dawley rats were fed a control or ethanol-containing liquid diet (12.5% EtOH v/v) from 4 days prior to mating until 4 days of gestation (n=12/group). A subset of offspring was fed a HFD between 3-8 months of age...
October 31, 2017: American Journal of Physiology. Endocrinology and Metabolism
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