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https://www.readbyqxmd.com/read/28652916/tunable-delayed-controlled-release-profile-from-layered-polymeric-microparticles
#1
D Dutta, C Fauer, K Hickey, M Salifu, S E Stabenfeldt
Composite microparticles (MPs) with layered architecture, engineered from poly(L-lactic acid) (PLLA) and poly(D,L-lactic-co-glycolic acid) (PLGA), are promising devices for achieving the delayed release of proteins. Here, we build on a water-in-oil-in-oil-in-water emulsion method of fabricating layered MPs with an emphasis on modulating the delay period of the protein release profile. Particle hardening parameters (i.e. polymer precipitation rate and total hardening time) following water-in-oil-in-oil-in-water emulsions are known to affect MP structure such as the core/shell material and cargo localization...
June 21, 2017: Journal of Materials Chemistry. B, Materials for Biology and Medicine
https://www.readbyqxmd.com/read/28652135/endocrine-disruption-of-phenanthrene-in-the-protogynous-dusky-grouper-epinephelus-marginatus-serranidae-perciformes
#2
Mariana Frias de Campos, Fabiana L Lo Nostro, Rodrigo H Da Cuña, Renata Guimarães Moreira
The dusky grouper Epinephelus marginatus is a protogynous hermaphrodite fish, that maintains high levels of plasma steroids as juveniles, as substrates for sex inversion. These fish are exposed to marine pollution from oil spills during cargo handling. Polycyclic aromatic hydrocarbons (PAHs), such as phenanthrene (Phe), are the main crude oil components and are toxic to fish, acting as endocrine disruptors (ED). This is the first study that investigated impacts of Phe as an ED in E. marginatus juveniles. An in vivo sublethal exposure (96 h) to Phe was carried out at two concentrations (0...
June 23, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28646664/wogonin-attenuates-inflammation-by-activating-ppar-%C3%AE-in-alcoholic-liver-disease
#3
Hai-Di Li, Xin Chen, Yang Yang, Hui-Min Huang, Ling Zhang, Xin Zhang, Lei Zhang, Cheng Huang, Xiao-Ming Meng, Jun Li
Alcoholic liver disease (ALD) is one of the predominant causes of liver-related morbidity and mortality worldwide. However, effective therapy for ALD is still lacking. Wogonin, a major flavonoid compound, is found in Scutellaria baicalensis Georgi. Accumulating studies have revealed that wogonin possesses anti-inflammatory and anti-tumour activities in various models. However, the hepatoprotective activity of wogonin in ALD is still obscure. In this study, we found that wogonin significantly attenuated inflammatory response in EtOH-fed mice, and reduced the expression of inflammatory cytokines such as TNF-α and IL-6 in EtOH-induced RAW264...
June 21, 2017: International Immunopharmacology
https://www.readbyqxmd.com/read/28631155/a-simple-and-facile-synthesis-of-tricyclic-fused-pyrimido-4-5-b-indol-2-amines
#4
Wentao Gao, Dongfang Wang, Yang Li
In the present investigation, a simple and facile synthetic strategy for the construction of a series of structurally interesting tricyclic-fused N-alkyl-9H-pyrimido[4,5-b]indol-2-amines has been successfully achieved. Our synthesis, based on the annulation reaction between readily available 2-chloroindole-3-carbaldehydes or 3-acetyl-2-chloroindoles and guanidine nitrate using KOH as the base in refluxing EtOH medium, has the attractive features such as mild and economical reaction conditions and easy handing with lesser impact on the environment...
June 19, 2017: Molecular Diversity
https://www.readbyqxmd.com/read/28629538/bioassay-guided-isolation-of-saikosaponins-with-agonistic-activity-on-5-hydroxytryptamine-2c-receptor-from-bupleurum-chinense-and-their-potential-use-for-the-treatment-of-obesity
#5
Chang-Li Sun, Chang-An Geng, Xiao-Yan Huang, Yun-Bao Ma, Xiao-Hong Zheng, Tong-Hua Yang, Xing-Long Chen, Xiu-Juan Yin, Xue-Mei Zhang, Ji-Jun Chen
5-Hydroxytryptamine 2C (5-HT2C) receptor is one of the major targets of anti-obesity agents, due to its role in regulation of appetite. In the present study, the 70% EtOH extract of the roots of Bupleurum chinense was revealed to have agonistic activity on 5-HT2C receptor, and the subsequent bioassay-guided isolation led to identification of several saikosaponins as the active constituents with 5-HT2C receptor agonistic activity in vitro and anti-obesity activity in vivo. The new compound, 22-oxosaikosaponin d (1), was determined by extensive spectroscopic analyses (HR-ESI-MS, IR, and 1D and 2D NMR)...
June 2017: Chinese Journal of Natural Medicines
https://www.readbyqxmd.com/read/28623343/data-driven-nanomechanical-sensing-specific-information-extraction-from-a-complex-system
#6
Kota Shiba, Ryo Tamura, Gaku Imamura, Genki Yoshikawa
Smells are known to be composed of thousands of chemicals with various concentrations, and thus, the extraction of specific information from such a complex system is still challenging. Herein, we report for the first time that the nanomechanical sensing combined with machine learning realizes the specific information extraction, e.g. alcohol content quantification as a proof-of-concept, from the smells of liquors. A newly developed nanomechanical sensor platform, a Membrane-type Surface stress Sensor (MSS), was utilized...
June 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28622627/changes-in-nonhuman-primate-brain-function-following-chronic-alcohol-consumption-in-previously-na%C3%A3-ve-animals
#7
Jared A Rowland, Jennifer R Stapleton-Kotloski, Greg E Alberto, April T Davenport, Robert J Kotloski, David P Friedman, Dwayne W Godwin, James B Daunais
INTRODUCTION: Chronic alcohol abuse is associated with neurophysiological changes in brain activity; however, these changes are not well localized in humans. Non-human primate models of alcohol abuse enable control over many potential confounding variables associated with human studies. The present study utilized high-resolution magnetoencephalography (MEG) to quantify the effects of chronic EtOH self-administration on resting state (RS) brain function in vervet monkeys. METHODS: Adolescent male vervet monkeys were trained to self-administer ethanol (n=7) or an isocaloric malto-dextrin solution (n=3)...
May 30, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28617609/transition-metal-free-photoinduced-intramolecular-annulation-of-2-3-di-hetero-arylchromen-4-one
#8
Jie Han, Tao Wang, Yong Liang, Ying Li, Chenchen Li, Rui Wang, Siqi Feng, Zunting Zhang
An efficient transition-metal-free photoinduced intracyclization of 4H-chromen-4-ones in EtOH-H2O (7:1, v/v) at ambient temperature for the construction of complicated fused-ring heteroaromatics is established. The reaction proceeds smoothly without requiring any catalysts/additives.
June 15, 2017: Organic Letters
https://www.readbyqxmd.com/read/28614590/chronic-ethanol-during-adolescence-impacts-corticolimbic-dendritic-spines-and-behavior
#9
Nicholas J Jury, Gabrielle A Pollack, Meredith J Ward, Jessica L Bezek, Alexandra J Ng, Courtney R Pinard, Hadley C Bergstrom, Andrew Holmes
BACKGROUND: Risk for alcohol use disorders (AUDs) in adulthood is linked to alcohol drinking during adolescence, but understanding of the neural and behavioral consequences of alcohol exposure during adolescence remains incomplete. Here, we examined the neurobehavioral impact of adolescent chronic intermittent EtOH (CIE) vapor exposure in mice. METHODS: C57BL/6J-background Thy1-EGFP mice were CIE-exposed during adolescence or adulthood and examined, as adults, for alterations in the density and morphology of dendritic spines in infralimbic (IL) cortex, prelimbic (PL) cortex, and basolateral amygdala (BLA)...
June 14, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28611604/on-the-accuracy-of-in-vivo-ethanol-and-acetaldehyde-monitoring-a-key-tile-in-the-puzzle-of-acetaldehyde-as-a-neuroactive-agent
#10
REVIEW
Paolo Enrico, Marco Diana
Over the last 20 years researchers have explored the postulated role of acetaldehyde (ACD) as a mediator of some of the actions of ethanol (EtOH) in the central nervous system (CNS). However, efforts have been hampered mainly by the difficulty of directly measuring in vivo EtOH and ACD levels in the CNS and thus, our knowledge is based on indirect evidences. Although technically challenging, the development of reliable methods for in vivo measurement of ACD and EtOH is of paramount importance to solve the "puzzle of acetaldehyde as a neuroactive agent...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28609672/development-of-a-new-extraction-technique-and-hplc-method-for-the-analysis-of-non-psychoactive-cannabinoids-in-fibre-type-cannabis-sativa-l-hemp
#11
Virginia Brighenti, Federica Pellati, Marleen Steinbach, Davide Maran, Stefania Benvenuti
The present work was aimed at the development and validation of a new, efficient and reliable technique for the analysis of the main non-psychoactive cannabinoids in fibre-type Cannabis sativa L. (hemp) inflorescences belonging to different varieties. This study was designed to identify samples with a high content of bioactive compounds, with a view to underscoring the importance of quality control in derived products as well. Different extraction methods, including dynamic maceration (DM), ultrasound-assisted extraction (UAE), microwave-assisted extraction (MAE) and supercritical-fluid extraction (SFE) were applied and compared in order to obtain a high yield of the target analytes from hemp...
June 4, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/28602852/repeated-ethanol-exposure-alters-social-behavior-and-oxidative-stress-parameters-of-zebrafish
#12
Talise Ellwanger Müller, Stenio Zimermann Nunes, Ariane Silveira, Vania Lucia Loro, Denis Broock Rosemberg
Repeated ethanol (EtOH) consumption induces neurological disorders in humans and is considered an important public health problem. The physiological effects of EtOH are dose- and time-dependent, causing relevant changes in the social behavior. In addition, alcohol-induced oxidative stress has been proposed as a key mechanism involved in EtOH neurotoxicity. Here we investigate for the first time whether repeated EtOH exposure (REE) alters the social behavior of zebrafish and influences brain oxidation processes...
June 7, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28597654/oms-2-supported-cu-hydroxide-catalyzed-benzoxazoles-synthesis-from-catechols-and-amines-via-domino-oxidation-process-at-room-temperature
#13
Xu Meng, Yanmin Wang, Yuanguang Wang, Baohua Chen, Zhenqiang Jing, Gexin Chen, Peiqing Zhao
In the presence of manganese oxide octahedral molecular sieve (OMS-2) supported copper hydroxide Cu(OH)x/OMS-2, aerobic synthesis of benzoxazoles from catechols and amines via domino oxidation/cyclization at room temperature is achieved. This heterogeneous benzoxazoles synthesis initiated by the efficient oxidation of catechols over Cu(OH)x/OMS-2 tolerates a variety of substrates, especially amines containing sensitive groups (hydroxyl, cyano, amino, vinyl, ethynyl, ester, and even acetyl groups) and heterocycles, which affords functionalized benzoxazoles in good to excellent yields by employing low catalyst loading (2 mol % Cu)...
June 14, 2017: Journal of Organic Chemistry
https://www.readbyqxmd.com/read/28596027/gelsedine-type-oxindole-alkaloids-from-gelsemium-elegans-and-the-evaluation-of-their-cytotoxic-activity
#14
Lei Wang, Jin-Feng Wang, Xia Mao, Li Jiao, Xiao-Jun Wang
Phytochemical investigation on the 70% EtOH extract of the leaves and branches of Gelsemium elegans resulted into the isolation of five new gelsedine-type oxindole alkaloids, gelseleganins A-E (1-5). The structures of the isolated compounds were established based on 1D and 2D ((1)H-(1)H COSY, HMQC, and HMBC) NMR spectroscopy, in addition to high resolution mass spectrometry. The isolated alkaloids were tested in vitro for cytotoxic potential against seven tumor cell lines. As a result, alkaloids 3 exhibited significant cytotoxic activities against all the tested tumor cell lines with IC50 values <10μM...
June 6, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28595942/multicomponent-access-to-androstano-arylpyrimidines-under-microwave-conditions-and-evaluation-of-their-anti-cancer-activity-in-vitro
#15
Ádám Baji, Tamás Kiss, János Wölfling, Dávid Kovács, Nóra Igaz, Mohana Krishna Gopisetty, Mónika Kiricsi, Éva Frank
Novel ring D- and A-fused pyrimidines in the androstane series were efficiently synthesized within 10-15min in polar protic solvents under microwave irradiation via two kinds of multicomponent heterocyclization reactions followed by spontaneous or promoted oxidation. The rates of the one-pot catalyst-free transformations of steroidal β-ketoaldehydes, ammonium acetate and substituted benzaldehydes in EtOH were found to be affected slightly by the steric and electronic feature of the substituents on the aromatic ring of the arylaldehyde component and the different reactivities of rings D and A of the sterane core...
June 5, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28594158/high-%C3%AE%C2%BA-samarium-based-metal%C3%A2-organic-framework-for-gate-dielectric-applications
#16
Abhishek Pathak, Guan Ru Chiou, Narsinga Rao Gade, Muhammad Usman, Shruti Mendiratta, Tzuoo-Tsair Luo, Tien-Wen Tseng, Jenq-Wei Chen, Fu-Rong Chen, Kuei-Hsien Chen, Li-Chyong Chen, Kuang-Lieh Lu
The self-assembly of a samarium-based metal‒organic framework [Sm2(bhc)(H2O)6]n (1) in good yield was achieved by reacting Sm(NO3)3‧6H2O with benzenehexacarboxylic acid (bhc) in a mixture of H2O‒EtOH under hydrothermal conditions. A structural analysis showed that compound 1 crystallized in a space group of Pnmn and adopted a 3D structure with (4,8) connected nets. Temperature dependent dielectric measurements showed that compound 1 behaves as a high dielectric material with a high dielectric constant (κ = 45...
June 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28588461/modulation-of-ethanol-metabolizing-enzymes-by-developmental-lead-exposure-effects-in-voluntary-ethanol-consumption
#17
Miriam B Virgolini, Mara S Mattalloni, Paula A Albrecht, Romina Deza-Ponzio, Liliana M Cancela
This review article provides evidence of the impact of the environmental contaminant lead (Pb) on the pattern of the motivational effects of ethanol (EtOH). To find a mechanism that explains this interaction, the focus of this review article is on central EtOH metabolism and the participating enzymes, as key factors in the modulation of brain acetaldehyde (ACD) accumulation and resulting effect on EtOH intake. Catalase (CAT) seems a good candidate for the shared mechanism between Pb and EtOH due to both its antioxidant and its brain EtOH-metabolizing properties...
2017: Frontiers in Behavioral Neuroscience
https://www.readbyqxmd.com/read/28579596/aldehyde-dehydrogenase-activity-identifies-a-subpopulation-of-canine-adipose-derived-stem-cells-with-higher-differentiation-potential
#18
Harumichi Itoh, Shimpei Nishikawa, Tomoya Haraguchi, Yu Arikawa, Shotaro Etoh, Toshie Iseri, Kenji Tani, Munekazu Nakaichi, Yasuho Taura, Kazuhito Itamoto
Adipose-derived stem cells (ADSCs) are abundant and readily obtained, and have been studied for their clinical applicability in regenerative medicine. Some surface antigens have been identified as markers of different ADSC subpopulations in mice and humans. However, it is unclear whether functionally distinct subpopulations exist in dogs. To address this issue, we evaluated aldehyde dehydrogenase (ALDH) activity-a widely used stem cell marker in mice and humans-by flow cytometry. Approximately 20% of bulk ADSCs showed high ALDH activity...
June 5, 2017: Journal of Veterinary Medical Science
https://www.readbyqxmd.com/read/28575797/prediction-of-crystal-morphology-of-3-4-dinitro-1h-pyrazole-dnp-in-different-solvents
#19
Liang Song, Lizhen Chen, Jianlong Wang, Feng Chen, Guanchao Lan
Analytical grade ethyl acetate was used to recrystallize 3,4-Dinitro-1H-pyrazole (DNP), it was found that there were two different morphologies of the crystals. There is a possibility that ethyl acetate undergoes hydrolysis due to the absorption of moisture in the air. The influence of the hydrolysis products of acetic acid and ethanol on the morphology of DNP crystal was considered. In order to investigate the effect of solvents on DNP morphology, there is ongoing research to validate molecular dynamics (MD) simulation results with experiment data...
March 23, 2017: Journal of Molecular Graphics & Modelling
https://www.readbyqxmd.com/read/28573273/quantitative-isotopic-measurements-of-gas-phase-alcohol-mixtures-using-a-broadly-tunable-swept-external-cavity-quantum-cascade-laser
#20
B E Brumfield, M C Phillips
A swept-ECQCL is used for broadband IR spectroscopy of isotopic mixtures of CH3OH, CH3OD, CH3CH2OH, and CH3CH2OD in a static gas cell over a wavelength range of 9.5 to 10.4 μm. A weighted least squares fitting approach with quantitative library spectra illustrates that significant spectral congestion does not negatively impact the ability for in situ quantification of large isotopic species in a mixture. The noise equivalent concentrations for CH3OH, CH3OD, CH3CH2OH, and CH3CH2OD are 19 ppbv m, 28 ppbv m, 450 ppbv m, and 350 ppbv m respectively for a 50 seconds integration time...
June 2, 2017: Analyst
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