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Youngshim Choi, Mohamed A Abdelmegeed, Byoung-Joon Song
Indole-3-carbinol (I3C), found in Brassica family vegetables, exhibits antioxidant, anti-inflammatory, and anti-cancerous properties. Here, we aimed to evaluate the preventive effects of I3C against ethanol (EtOH)-induced liver injury and study the protective mechanism(s) by using the well-established chronic-plus-binge alcohol exposure model. The preventive effects of I3C were evaluated by conducting various histological, biochemical, and real-time PCR analyses in mouse liver, adipose tissue, and colon, since functional alterations of adipose tissue and intestine can also participate in promoting EtOH-induced liver damage...
December 10, 2017: Journal of Nutritional Biochemistry
Shufang Wang, Yongxin Gao, Shigang Shen, Hui Wen, Huaqing Cui
C5-modified uridines are a valuable class of nucleoside analogues, both as potent chemotherapy agents and through their use as the conjunction site in DNA labeling strategies. As an important C5-modified uridine, BrdU has been used in cell proliferation assays since the 1980s. Currently, the detection of BrdU relies on traditional immunostaining; however, this approach has its limitations. Thus, it is desirable, albeit difficult, to develop chemistry methods to fluorescently label BrdU in a cellular context...
January 12, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Elena S Catap, Markyn Jared L Kho, Maria Rexie R Jimenez
ETHNOPHARMACOLOGICAL RELEVANCE: Portulaca oleracea (common purslane) is used in traditional medicine to cure various illnesses. However, its immune-protective properties and antispasmodic effects still need more pharmacological data if the plant will be utilized in herbal and drug formulations. Therefore, the present study determined the capacity of this plant species to modulate nonspecific immune responses and to confirm its antispasmodic activity in vivo in ICR mice. MATERIALS AND METHODS: Phagocytic activity of peritoneal macrophage, splenic lymphocyte proliferation and plasma lysozyme levels were measured in mice that were immunosuppressed using cyclophosphamide and treated with the ethyl acetate extract of Portulaca oleracea...
January 8, 2018: Journal of Ethnopharmacology
Grzegorz Kłosowski, Dawid Mikulski, Aleksandra Rolbiecka, Bogusław Czupryński
The aim of the study was to determine the influence of the source material and the applied S. cerevisiae strain on the concentrations of carbonyl fractions in raw spirits. Acetaldehyde was the most common aldehyde found, as it accounted for 88-92% of the total amount of aldehydes. The concentration of acetaldehyde in maize, rye and amaranth mashes was highly correlated with fermentation productivity at a given phase of the process, and reached its highest value of 193.5 mg/l EtOH in the first hours of the fermentation, regardless of the yeast strain applied...
September 27, 2017: Polish Journal of Microbiology
Óscar Guzmán-Méndez, Federico González, Sylvain Bernès, Marcos Flores-Álamo, Javier Ordóñez-Hernández, Héctor García-Ortega, Joselin Guerrero, Wenjie Qian, Nuria Aliaga-Alcalde, Laura Gasque
A chelating coumarin-derived ligand sensitizes all emitting lanthanide ions in the solid state and gives high absolute quantum yields for ethanol solutions of complexes of Sm, Eu, Tb, and Dy, above 20% for the last two. Crystal structures of these four complexes are [Ln(Cum)3(H2O)(X)]·X where X = MeOH or EtOH.
January 8, 2018: Inorganic Chemistry
Maria M Rubinstein, Andreas Kaubisch, Milan Kinkhabwala, John Reinus, Qiang Liu, Jennifer W Chuy
Background: Orthotopic liver transplantation (OLT) is the most effective treatment for hepatocellular carcinoma (HCC) in patients with underlying cirrhosis and portal hypertension. Availability of OLT is limited by donor-organ shortages, which increase patient waiting time until OLT. A variety of bridging therapies (BT) have been used to halt tumor progression in patients on the OLT waiting list. Despite complete radiologic responses following BT, viable tumor is often present in explants...
December 2017: Journal of Gastrointestinal Oncology
Mingchang Zhu, Tingting Peng, Na Sun, Xue Qiu, Yang Zhan, Yuqing Ding, Shaozhong Zhang, Enjun Gao
A set of five metal-organic frameworks, namely, [Cd2(L)2BIP(H2O)2·6H2O]n(1), [Ce(L)1.5(H2O)2·H2O]n(2),[Sm(L)1.5(H2O)2·3H2O]n(3),[Gd(L)1.5(H2O)2·3H2O]n(4),[Ho(L)1.5(H2O)2·3H2O]n(5), have been prepared under hydrothermal conditions (1,4-H2L=1,4-Pheny lenedioxydiacetic acid; 1,4-BIP=1,4-bis(2-pyridylmethyl)piperazi-ne; C2H5OH=EtOH). The long BIP ligand (N⋯N separation of ca. 8.355Å) induces interpenetration of 1 to increase both the framework stability and the density of effective catalytic metal centers...
November 11, 2017: Journal of Inorganic Biochemistry
Ronald Farrar-Tobar, Zhihong Wei, Haijun Jiao, Sandra Hinze, Johannes Gerardus de Vries
Commercially available Ru-MACHOTM-BH is an active catalyst for the hydrogenation of several functional groups and for the dehydrogenation of alcohols. Herein, we report on the new application of this catalyst to the base-free transfer hydrogenation of carbonyl compounds. Ru-MACHOTM-BH proved to be highly active and selective in this transformation, even with α,β-unsaturated carbonyl compounds as substrates. The corresponding aliphatic, aromatic and allylic alcohols were obtained in excellent yields with catalyst loadings as low as 0...
December 28, 2017: Chemistry: a European Journal
Fabio Priante, Maan Salim, Luca Ottaviano, Francesco Perrozzi
The reduction of graphene oxide (GO) has been extensively studied in literature in order to let GO partially recover the properties of graphene. Most of the techniques proposed to reduce GO are based on high temperature annealing or chemical reduction. A new procedure, based on the direct reduction of GO by etched Si substrate, was recently proposed in literature. In the present work, we accurately investigated the Si-GO interaction with X-ray photoelectron spectroscopy. In order to avoid external substrate oxidation factors we used EtOH as GO solvent instead of water, and thermal annealing was carried out in UHV...
December 20, 2017: Nanotechnology
Jianlin He, Wenfei Huang, Shizhong Zheng, Michael Vigorito, Sulie L Chang
Binge drinking affects the onset and progression of human immunodeficiency virus (HIV)-associated neurological disorders. The HIV-1 transgenic (HIV-1Tg) rat was created with a gag- and pol-deleted HIV-1 viral genome to mimic HIV-infected patients receiving combination anti-retroviral therapy (cART). Docosahexaenoic acid (DHA) is a marine compound that modulates inflammatory responses. Using HIV-1Tg rats subjected to binge exposure to ethanol (EtOH), this study examined whether DHA could reduce the detrimental neurological effects of EtOH and HIV proteins...
December 19, 2017: Journal of Neurovirology
Sullim Lee, No-June Park, Sim-Kyu Bong, Jonghwan Jegal, Sang-A Park, Su-Nam Kim, Min-Hye Yang
ETHNOPHARMACOLOGICAL RELEVANCE: The fruits of Juniperus rigida have been used in Korean traditional medicine for the treatment of inflammatory diseases in humans such as rheumatoid arthritis. AIM OF THE STUDY: This study aimed to investigate the anti-atopic properties of J. rigida fruit in in vivo murine atopic dermatitis (AD) models. METHODS AND RESULTS: BALB/c mouse ears ad SKH-1 hairless mice stimulated with oxazolone (4 weeks) and DNCB (3 weeks), respectively, were treated with the 1% Juniperus rigida fruit EtOH extract (JFE)...
December 16, 2017: Journal of Ethnopharmacology
Aneta Spórna-Kucab, Angelika Milo, Agnieszka Kumorkiewicz, Sławomir Wybraniec
Betacyanins, natural plant pigments exhibiting antioxidant and chemopreventive properties, were extracted from Celosia spicata (Thouars) Spreng. inflorescences and separated by high-speed counter-current chromatography (HSCCC) in two polar solvent systems composed of: TBME - 1-BuOH - ACN - H2O (0.7% HFBA, 2:2:1:5, v/v/v/v) (system I) and EtOH - ACN - 1-PrOH - (NH4)2SO4satd.soln - H2O (0.5:0.5:0.5:1.2:1, v/v/v/v/v) (system II). The systems were used in the head-to-tail (system I) and tail-to-head (system II) mode...
November 23, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Ling-Juan Zhu, Ying Song, Peng Shao, Xue Zhang, Xin-Sheng Yao
Two new phenolics, named matteucens I-J (1-2), were isolated from the 60% EtOH extract of the rhizomes of Matteuccia orientalis (HOOK.) TREV. Their structures were elucidated by means of extensive spectroscopic analysis (HRESIMS, NMR).
December 13, 2017: Journal of Asian Natural Products Research
Alessio Dessì, Matteo Monai, Matteo Bessi, Tiziano Montini, Massimo Calamante, Alessandro Mordini, Gianna Reginato, Cosimo Trono, Paolo Fornasiero, Lorenzo Zani
Donor-acceptor dyes are a well-established class of photosensitizers, used to enhance visible light harvesting in solar cells and in direct photocatalytic reactions, such as H2 production by photoreforming of sacrificial electron donors (SEDs). Amines - typically triethanolamine (TEOA) - are commonly employed as SEDs in such reactions. Dye-sensitized photoreforming of more sustainable, biomass-derived alcohols, on the other hand, was only recently reported using methanol as the electron donor. In this work, several rationally designed donor-acceptor dyes were used as sensitizers in H2 photocatalytic production, comparing the efficiency of TEOA and EtOH as SEDs...
December 11, 2017: ChemSusChem
Yoojin Seo, Youngmee Jung, Soo Hyun Kim
Initial angiogenesis within the first 3 days is critical for healing ischemic diseases such as myocardial infarction. Recently, decellularized extracellular matrix (dECM) has been reported to provide tissue-derived ECM components and can be used as a scaffold for cell delivery for angiogenesis in tissue engineering. Decellularization by various detergents such as sodium dodecyl sulfate (SDS) and triton X-100 can remove the cell nuclei in tissue organs. However, this leads to ECM structure denaturation, decreased presence of various ECM proteins and cytokines, and loss of mechanical properties...
December 6, 2017: Acta Biomaterialia
F Biggio, G Talani, V Locci, M G Pisu, G Boero, B Ciarlo, D R Grayson, M Serra
Adverse maternal behaviors during pregnancy and unfavorable postnatal experiences during development are associated with an increased risk of developing psychiatric disorders, as well as, a vulnerability to alcohol addiction in adulthood. Here, we examined the effects of combined ethanol exposure during late pregnancy and postnatal maternal separation (MS) on HPA responsiveness, anxiety behavior and preference for alcohol consumption in adult male rats. Animals exposed to both conditions revealed a decrease in blood levels of allopregnanolone accompanied by increased anxiety behavior...
December 6, 2017: Neuropharmacology
Ya Gao, Lihan Zhu, Jing Guo, Ting Yuan, Liqing Wang, Hua Li, Lixia Chen
Cancer cells are more addictive to MTH1 than normal cells because of their dysfunctional redox regulations. MTH1 plays an important role to maintain tumor cell survival, while it is not indispensable for the growth of normal cells. Farnesyl phenols having a coumaroyl substitution are rather uncommon in nature. Eight farnesyl phenolic compounds with such substituent moiety (1-8), including six new ones, ganosinensols E-J (1-6) were isolated from the 95% EtOH extract of the fruiting bodies of Ganoderma sinense...
November 10, 2017: Oncotarget
Jianwei Ma, Takahiro Hiratsuka, Tsuyoshi Etoh, Junko Akada, Hajime Fujishima, Norio Shiraishi, Yoshio Yamaoka, Masafumi Inomata
BACKGROUND AND AIM: Infection by Helicobacter pylori is implicated in a wide range of upper gastrointestinal diseases. Owing to the rapid emergence of antibiotic-resistant strains of H. pylori, the development of novel treatment modalities for antibiotic-resistant H. pylori infection is a key priority. Blue light-emitting diodes (LED) may represent a unique option owing to their antimicrobial effect. In this study, we aimed to evaluate the anti-proliferative effect of blue LED against antibiotic-resistant H...
December 7, 2017: Journal of Gastroenterology and Hepatology
Tsuyoshi Etoh, Michitaka Honda, Hiraku Kumamaru, Hiroaki Miyata, Kazuhiro Yoshida, Yasuhiro Kodera, Yoshihiro Kakeji, Masafumi Inomata, Hiroyuki Konno, Yasuyuki Seto, Seigo Kitano, Naoki Hiki
BACKGROUND: Controversy persists regarding the technical feasibility of laparoscopic total gastrectomy (LTG), and to our knowledge, no prospective study with a sample size sufficient to investigate its safety has been reported. We aimed to compare the postoperative morbidity and mortality rates in patients undergoing LTG and open total gastrectomy (OTG) for gastric cancer in prospectively enrolled cohort using nationwide web-based registry. METHODS: From August 2014 to July 2015, consecutive patients undergoing LTG or OTG (925 and 1569 patients, respectively) at the participating institutions were enrolled prospectively into the National Clinical Database registration system...
December 7, 2017: Surgical Endoscopy
Muhammad Hamza Humayun, Syed Sultan Shah Bukhari, Muhammad Zakwan, Mustafa Mert Bayer, Ulaş Sabahattin Gökay, Ali Serpengüzel, Kenichi Taira, Etsuji Omura, Josuke Nakata
The transverse spatial intensity distribution of elastic and inelastic light scattering in passive and active as well as weak and strong scattering liquid media has been studied by using Sphelar One p-n junction silicon spherical photocells. We immersed a Sphelar One in these scattering solutions and measured the photoconductive response in reverse biased photodiode (PD) configuration. The passive weak scattering medium was pure ethanol (EtOH), whereas the passive strong scattering medium was 5CB nematic liquid crystal (NLC)...
December 1, 2017: Applied Optics
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