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Yasmine Chemam, Samir Benayache, Eric Marchioni, Minjie Zhao, Paul Mosset, Fadila Benayache
Many Helianthemum species (Cistaceae) are recognized for their various medicinal virtues. Helianthemum ruficomum is an endemic species to the septentrional Sahara on which no report is available so far. The purpose of this work was to investigate the chemical composition and the radical scavenging capacity of this species and its isolated components. Collected from Mougheul (south-west of Algeria), the aerial parts were macerated with 80% EtOH/H₂O, after evaporation, the remaining extract was diluted with H₂O and extracted with petroleum ether, chloroform, ethyl acetate and n-butanol...
February 8, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Sadahiro Yagishita, Akiko Himegi, Ken Kanazashi, Tomomi Ohishi, Ryuta Ishikawa, Tomohiko Hamaguchi, Satoshi Kawata
Hydrogen-bond supported intercalation compounds constructed from three types of two-dimensional layers and common guests, {(Hha)2[Cu(CA)2(EtOH)2]}n (1), {(Hha)2[Cu(CA)2(EtOH)]}n (2), and {(Hha)2[Cu(CA)2]}n (3) (ha = hexylamine), have been synthesized and characterized. The hexylaminium cations are introduced between the anionic layers of the metal-chloranilate by not only electrostatic interactions but also hydrogen bonding interactions. These compounds show reversible EtOH adsorption and desorption accompanied by a structural transformation...
February 15, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Dominika Hosová, Linda Patia Spear
BACKGROUND: The still maturing adolescent brain may be particularly vulnerable to lasting consequences of ethanol (EtOH) exposure. Yet, human adolescents are the age group most likely to engage in binge drinking (a pattern of drinking leading to blood EtOH concentrations (BECs) of 80 mg/dl or greater). Most studies to date assessing the long-term effects of adolescent EtOH exposure in outbred rodent populations have either used experimenter-administered EtOH to produce BECs in the binge range or assessed voluntary intake of EtOH at well below binge levels...
February 14, 2017: Alcoholism, Clinical and Experimental Research
Erica Liberto, Cecilia Cagliero, Chiara Cordero, Patrizia Rubiolo, Carlo Bicchi, Barbara Sgorbini
Recent technological advances in dynamic headspace sampling (D-HS) and the possibility to automate this sampling method have lead to a marked improvement in its the performance, a strong renewal of interest in it, and have extended its fields of application. The introduction of in-parallel and in-series automatic multi-sampling and of new trapping materials, plus the possibility to design an effective sampling process by correctly applying the breakthrough volume theory, have make profiling more representative, and have enhanced selectivity, and flexibility, also offering the possibility of fractionated enrichment in particular for high-volatility compounds...
February 7, 2017: Journal of Chromatography. A
Leilei Luo, Yucang Liang, Egil Sev Erichsen, Reiner Anwander
Monodisperse and uniform high-quality MCM(Mobil Composition of Matter)-48-type CMSNs (Cubic Mesoporous Silica Nanoparticles) are readily prepared by simply optimizing the molar ratio of ethanol and surfactant in the system TEOS-CTAB-NaOH-H2O-EtOH (TEOS=tetraethyl orthosilicate, CTAB=cetyltrimethylammonium bromide, EtOH=ethanol). In the absence of ethanol only hexagonal mesoporous silica with ellipsoidal and spherical morphology are obtained. The presence of ethanol drives a mesophase transformation from hexagonal to mixed hexagonal/cubic, further to purely cubic, and finally to a mixed cubic/lamellar...
January 31, 2017: Journal of Colloid and Interface Science
Anup Pandith, Giridhari Hazra, Hong-Seok Kim
A novel simple fluorescent probe was designed for the recognition of electron-rich salicylic acid derivatives (SAs). The imidazole-appended aminomethyl perylene probe 1 selectively differentiated between electron-rich amino-SAs and electron-deficient nitro-SAs in EtOH, exhibiting the highest selectivity and sensitivity toward 5-aminosalicylic acid (5-ASA) and showing strong 1:1 binding (Ka=1.37×10(7)M(-1)). This high selectivity and sensitivity resulted from the synergistic multiple hydrogen bonding interactions of secondary amine and imidazole units and π-π interactions between electron-rich and electron-deficient rings, along with the unusual NH-π interactions between 5-ASA and the perylene moiety of 1...
February 3, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Manjula Ravi, Srinivasarao Allu, K C Kumara Swamy
An efficient Rh(III)-catalyzed ortho-alkylation of phenoxy substrates with diazo compounds has been achieved for the first time using pyrimidine or pyridine as the directing group. Furthermore, bis-alkylation has also been achieved using para-substituted phenoxypyrimidine using 3 mole equiv of the diazo ester. The ortho-alkylated derivatives of phenoxy products possessing the ester functionality undergo decarboxylative pyrimidine/pyridine migratory cyclization (rather than deprotection of pyrimidine/pyridine group) using 20% NaOEt in EtOH affording a novel class of 3-(pyrimidin-2(1H)-ylidene)benzofuran-2(3H)-ones and 6-methyl-3-(pyridin-2(1H)-ylidene)benzofuran-2(3H)-one...
February 9, 2017: Journal of Organic Chemistry
Rong Dai, Ting Wang, Xiaoqin Si, Yuanyuan Jia, Lili Wang, Yan Yuan, Qing Lin, Cui Yang
The objective of this study was to assess the ethyl acetate extracts of Gastrodia elata Blume (GEB) on vascular tone and the mechanisms involved. GEB was extracted with 95% EtOH followed by a further extraction with ethyl acetate. The effects of GEB and its ingredients on the isometric tensions of the aortic rings from rats were measured. The ethyl acetate extract of GEB induced a vasodilatatory effect on rat aorta which was partially dependent on endothelium. Four chemical compounds isolated from GEB were identified as 3, 4-dihydroxybenzaldehyde (DB), 4-hydroxy benzaldehyde (HB), 4-methoxybenzyl alcohol (MA) and 4, 4'-dihydroxydiphenyl methane (DM), respectively...
December 17, 2016: Canadian Journal of Physiology and Pharmacology
Jing Li, Caihong Fu, Hongwei Liu, Rao Fu, Wanhong Zuo, Seungwoo Kang, Pei Chen, Danielle Gregor, Rose Paulose, Alex Bekker, Jiang-Hong Ye
BACKGROUND: Hyperalgesia or increased sensitivity to pain is often found in alcoholics during alcohol withdrawal and may contribute to relapse drinking. Alternative therapies such as acupuncture and electroacupuncture (EA), through mechanisms involving opioid receptors, may reduce pain and substance dependence and withdrawal syndromes. The lateral habenula (LHb), an epithalamic structure rich in mu opioid receptors (MORs), is a critical target for both drugs of abuse and pain. We previously observed hyperalgesia in rats withdrawn from chronic ethanol (EtOH) drinking and found that EA at the acupoint Zusanli (ST36) reduced EtOH intake...
February 6, 2017: Alcoholism, Clinical and Experimental Research
Yuri A Blednov, Mendy Black, Jillian M Benavidez, Adriana Da Costa, Jody Mayfield, R Adron Harris
BACKGROUND: In our companion article, we examined the role of MyD88-dependent signaling in ethanol (EtOH) consumption in mice lacking key components of this inflammatory pathway and observed differential effects on drinking. Here, we studied the role of these same signaling components in the acute sedative, intoxicating, and physiological effects of EtOH. Toll-like receptor 4 (TLR4) has been reported to strongly reduce the duration of EtOH-induced sedation, although most studies do not support its direct involvement in EtOH consumption...
February 3, 2017: Alcoholism, Clinical and Experimental Research
Guilherme Henrique Souza Bomfim, Iago Méndez-López, Juan Alberto Arranz-Tagarro, Adriana Aparecida Ferraz Carbonel, Danilo Roman-Campos, Juan Fernando Padín, Antonio García García, Aron Jurkiewicz, Neide Hyppolito Jurkiewicz
Chronic ethanol (EtOH) consumption has been associated with deleterious effects on the cardiovascular system by abnormal calcium (Ca²⁺) handling. Store-operated Ca2+ entry (SOCE) is related to cardiovascular remodeling which leads to the hypertension development, and the coupling between STIM-1 (ER Ca2+ sensor) and Orai-1 (channel pore) is a key mechanism to control SOCE through of store-operated Ca2+ channels (SOCCs). However, the role of STIM-1/Orai-1-mediated SOCE and its cross-talk with EtOH-triggered vascular remodeling and hypertension remain poorly understood...
February 1, 2017: Current Vascular Pharmacology
Yuri A Blednov, Mendy Black, Julia Chernis, Adriana Da Costa, Jody Mayfield, R Adron Harris
BACKGROUND: Molecular and behavioral studies support a role for innate immune proinflammatory pathways in mediating the effects of alcohol. Increased levels of Toll-like receptors (TLRs) have been observed in animal models of alcohol consumption and in human alcoholics, and many of these TLRs signal via the MyD88-dependent pathway. We hypothesized that this pathway is involved in alcohol drinking and examined some of its key signaling components. METHODS: Different ethanol (EtOH)-drinking paradigms were studied in male and female control C57BL/6J mice versus mice lacking CD14, TLR2, TLR4 (C57BL/10ScN), or MyD88...
February 1, 2017: Alcoholism, Clinical and Experimental Research
Olga Botezat, Jan van Leusen, Victor Ch Kravtsov, Paul Kögerler, Svetlana G Baca
A family of wheel-shaped charge-neutral heterometallic {Fe(III)4Ln(III)2}- and {Fe(III)18M(III)6}-type coordination clusters demonstrates the intricate interplay of solvent effects and structure-directing roles of semiflexible bridging ligands. The {Fe4Ln2}-type compounds [Fe4Ln2(O2CCMe3)6(N3)4(Htea)4]·2(EtOH), Ln = Dy (1a), Er (1b), Ho (1c); [Fe4Tb2(O2CCMe3)6(N3)4(Htea)4] (1d); [Fe4Ln2(O2CCMe3)6(N3)4(Htea)4]·2(CH2Cl2), Ln = Dy (2a), Er (2b); [Fe4Ln2(O2CCMe3)4(N3)6(Htea)4]·2(EtOH)·2(CH2Cl2), Ln = Dy (3a), Er (3b) and the {Fe18M6}-type compounds [Fe18M6(O2CCHMe2)12(Htea)18(tea)6(N3)6]·n(solvent), M = Dy (4, 4a), Gd (5), Tb (6), Ho (7), Sm (8), Eu (9), and Y (10) form in ca...
January 30, 2017: Inorganic Chemistry
Yan-Cong Chen, Jun-Liang Liu, Yanhua Lan, Zhi-Qiang Zhong, Akseli Mansikkamäki, Liviu Ungur, Quan-Wen Li, Jian-Hua Jia, Liviu F Chibotaru, Jun-Bo Han, Wolfgang Wernsdorfer, Xiao-Ming Chen, Ming-Liang Tong
The pentagonal bipyramidal single-ion magnets (SIMs) are among the most attractive prototypes of high performance single-molecule magnets (SMMs). Here we introduced the fluorescene-active phosphine oxide ligand, combing the dynamic magnetic measurement, optical characterization and ab initio calculation, firstly studied the magneto-optical correlation of a pseudo-D5h Dy(III) SIM, [Dy(CyPh2PO)2(H2O)5]Br3*2(CyPh2PO)*EtOH*3H2O (CyPh2PO = cyclohexyl(diphenyl)phosphine oxide) with large Ueff = 508(2) K and high magnetic hysteresis temperature of 19 K...
January 30, 2017: Chemistry: a European Journal
Jandirk Sendker, Ines Böker, Isabelle Lengers, Simone Brandt, Joachim Jose, Timo Stark, Thomas Hofmann, Careen Fink, Heba Abdel-Aziz, Andreas Hensel
Extract RE was obtained from the roots of Althaea officinalis in a yield of 8.1%, related to the dried plant material, by extraction with MeOH-H2O (1:1), followed by precipitation with EtOH to remove high molecular weight constituents. Phytochemical investigation of RE revealed the presence of N-phenylpropenoyl-l-amino acid amides 1-5, 8% glycine betaine 6, about 9% total amino acids with proline as the main compound, and about 61% mono- and oligomeric carbohydrates with sucrose as the main compound. Further fractionation revealed the presence of a hypolaetin diglycoside (12) and four hypolaetin glycosides (7-9 and 11) with O-sulfocarbohydrate moieties; additionally, 4'-O-methylisoscutellarein-8-O-β-d-(3″-O-sulfo)glucuronopyranoside (10) and the diglycosylated coumarin haploperoside D (13) were identified...
January 27, 2017: Journal of Natural Products
Stuart J Malthus, Rajni K Wilson, A Vikas Aggarwal, Scott A Cameron, David S Larsen, Sally Brooker
The very different multi-step routes to the closely related pair of diformyl-carbazole head units, 1,8-diformyl-3,6-di-tert-butyl-9H-carbazole (1tBu) and 1,8-diformyl-9H-carbazole (1H), are detailed and compared. The first examples of Schiff base macrocycles derived from diformyl-carbazole head units are reported. Specifically, the direct cyclisation of 1tBu or 1H with diethylenetriamine gives the two metal-free [1 + 1] Schiff base macrocycles HLH and HLtBu in high yields. Four carbazole-based macrocyclic complexes, [Cu(II)L(OH2)]OAc and [Ni(II)L]OAc, where L = LH or LtBu, were accessed either by metallation of these macrocycles, or by metal templated reaction of the macrocycle components...
January 27, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
Lu Bai, Xueqin Cui, Ni Cheng, Wei Cao, Yong Wu, Sen Guo, Li Zhang, Chi-Tang Ho, Naisheng Bai
The hepatoprotective activity of the EtOH-water extract of Ziziphus jujuba leaves was evaluated against CCl4-induced hepatic damage in mice. The EtOH-water extract significantly alleviated liver damage as indicated by the decreased levels of serum ALT and AST and the decreased MDA content, the increased levels of SOD, GSH and GSH-Px, and the reduced pathological tissue injury induced by CCl4. A quantitative analysis of fifteen major constituents (1-15) of the EtOH-water extract of the leaves of Z. jujuba was conducted by HPLC-DAD...
January 26, 2017: Food & Function
Wieland Peschel
Traditional tinctures of Cannabis sativa L. became obsolete before elucidation of the main cannabinoids and routine quality testing for medicines. In view of increasing medicinal use of cannabinoids and associated safety concerns, tinctures from a Δ9-tetrahydrocannabinol (THC)-type chemovar were studied. High-performance liquid chromatography with diode-array detection (HPLC/DAD) was used to determine THC, Δ9-tetrahydrocannabinolic acid A (THCA), cannabinol (CBN), cannabidiol (CBD), cannabidiolic acid (CBDA), cannabigerol (CBG), cannabigerolic acid (CBGA), cannflavin A/B, and total phenolics...
April 18, 2016: Scientia Pharmaceutica
Guofeng Zhao, Songyu Fan, Xiaxia Pan, Pengjing Chen, Ye Liu, Yong Lu
A high-performance SiC-foam-structured nanocomposite catalyst of CoO@Cu2O, i.e., 50-100 nm CoO partially covered with ~10 nm Cu2O, is engineered from nano- to macro-scales in one step for high-throughput gas-phase aerobic oxidation of bioethanol to acetaldehyde. Such special CoO@Cu2O nanostructure shows much higher activity/selectivity than other binary metal-oxide assemblies such as CuOx&CoO nano-mixture and inverse Cu2O@CoO nanostructure. The catalyst is facilely but exclusively obtainable by in-situ reaction-induced transformation of their nitrates supported on SiC-foam into CoO@Cu2O nanostructure in the reaction stream, which delivers 95% conversion with 98% selectivity under mild conditions and is stable for at least 150 h for a feed of 20 vol% ethanol (much higher than the literature, 1-6 vol%) at a high EtOH weight hourly space velocity (WHSVEtOH) of 8...
January 23, 2017: ChemSusChem
Teresa Deuchande, Christian Larrigaudière, Umbelina Guterres, Susana M P Carvalho, Marta W Vasconcelos
BACKGROUND: The aim of this study was to identify biochemical markers to predict internal browning disorders (IBD) in 'Rocha' pear. Fruit from five orchards were stored for 45 days under cold air followed by 100 days in browning inducing controlled atmosphere (CA) conditions (1 kPa O2 + 10 kPa CO2 ). RESULTS: Relationships between concentrations of ethanol (EtOH), acetaldehyde (AcDH), ascorbic acid (AA) and the activities of peroxidase (POX) and polyphenoloxidase (PPO) and IBD incidence were established...
January 19, 2017: Journal of the Science of Food and Agriculture
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