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https://www.readbyqxmd.com/read/28926923/involvement-of-mapk-nf-%C3%AE%C2%BAb-signal-transduction-pathways-camellia-japonica-mitigates-inflammation-and-gastric-ulcer
#1
Md Rashedunnabi Akanda, Byung-Yong Park
Gastric ulcer is an important risk factor for human health globally. Camellia japonica (CJ) is a plant of which the fruits are used as traditional phytomedicine for inflammatory and immunomodulatory diseases; however, the underlying molecular mechanism has not been clarified. The present study aimed to investigate the immunopharmacological activities of Camellia japonica and validate its pharmacological targets. To evaluate the protective roles of Camellia japonica on LPS-induced inflammation in RAW 264.7 cells and HCl/EtOH-induced gastric ulcer in mice; we applied 3-(4,5-dimethyl-thiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), nitric oxide (NO), reactive oxygen species (ROS), histopathology, malondialdehyde (MDA), quantitative real-time polymerase chain reaction (qPCR), immunohistochemistry (IHC), and western blot analyses...
September 15, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28926039/tuning-linkage-isomerism-and-magnetic-properties-of-bi-and-tri-metallic-cage-silsesquioxanes-by-cation-and-solvent-effects
#2
Alexey N Bilyachenko, Alexander A Korlyukov, Anna V Vologzhanina, Victor N Khrustalev, Alena N Kulakova, Jérôme Long, Joulia Larionova, Yannick Guari, Marina S Dronova, Ulyana S Tsareva, Pavel V Dorovatovskii, Elena S Shubina, Mikhail M Levitsky
Herein, the effect of replacement of the surrounding solvent and/or the partial substitution of sodium ions in the cage-like copper, sodium phenylsilsesquioxane [(PhSiO1.5)12(CuO)4(NaO0.5)4(n-BuOH)6] 1 with a globular structure was investigated; the synthesis of ten new derivatives of complex 1 was performed, and their crystal structures were determined. Solvate replacement of n-butanol in 1 with dimethyl sulfoxide, acetonitrile, 1,4-dioxane/EtOH, and 1,4-dioxane/PhCN afforded the complexes [(PhSiO1.5)12(CuO)4(NaO0...
September 19, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/28921619/alcohol-reduces-arterial-remodeling-by-inhibiting-sonic-hedgehog-stimulated-sca1-progenitor-stem-cell-expansion
#3
Emma Fitzpatrick, Xu Han, Weimin Liu, Eoin Corcoran, Denise Burtenshaw, Maryam Alshamrani, David Morrow, Jay-Christian Helt, Paul A Cahill, Eileen M Redmond
BACKGROUND: Cell and molecular mechanisms mediating the cardiovascular effects of alcohol are not fully understood. Our aim was to determine the effect of moderate Ethanol (EtOH) on Sonic Hedgehog (SHh) signaling in regulating possible Sca1(+) progenitor stem cell involvement during pathologic arterial remodeling. METHODS AND RESULTS: Partial ligation or sham-operation of the left carotid artery was performed in transgenic Sca1-eGFP mice gavaged with or without 'daily moderate' EtOH...
September 18, 2017: Alcoholism, Clinical and Experimental Research
https://www.readbyqxmd.com/read/28919158/a-role-for-nucleus-accumbens-glutamate-in-the-expression-but-not-the-induction-of-behavioural-sensitization-to-ethanol
#4
Christina N Nona, José N Nobrega
Mechanisms underlying differential sensitivity to behavioural sensitization to ethanol (EtOH) remain poorly understood, although accumulating evidence suggests a role for glutamatergic processes in the ventral striatum. Efforts to address this issue can benefit from the well-documented fact that in any given cohort, some of the mice (High sensitized; HS) show robust sensitization, while others (Low sensitized; LS) show little, if any, sensitization. Here, we examined whether this variability might be differentially associated with nucleus accumbens (NAc) glutamate processes...
September 14, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28918081/developmental-alcohol-exposure-impairs-synaptic-plasticity-without-overtly-altering-microglial-function-in-mouse-visual-cortex
#5
Elissa L Wong, Nina M Lutz, Victoria A Hogan, Cassandra E Lamantia, Helene R McMurray, Jason R Myers, John M Ashton, Ania K Majewska
Fetal alcohol spectrum disorder (FASD), caused by gestational ethanol (EtOH) exposure, is one of the most common causes of non-heritable and life-long mental disability worldwide, with no standard treatment or therapy available. While EtOH exposure can alter the function of both neurons and glia, it is still unclear how EtOH influences brain development to cause deficits in sensory and cognitive processing later in life. Microglia play an important role in shaping synaptic function and plasticity during neural circuit development and have been shown to mount an acute immunological response to EtOH exposure in certain brain regions...
September 13, 2017: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/28917162/a-highly-selective-and-sensitive-turn-on-probe-for-aluminum-iii-based-on-quinoline-schiff-s-base-and-its-cell-imaging
#6
Fenfen Zhou, Hongqing Wang, Pengying Liu, Qinghua Hu, Yuyuan Wang, Can Liu, Jiangke Hu
A reversible Schiff's base fluorescence probe for Al(3+), (3,5-dichloro-2- hydroxybenzylidene) quinoline-2-carbohydrazide (QC), based on quinoline derivative has been designed, synthesized and evaluated. The QC exhibited a high sensitivity and selectivity toward Al(3+) in EtOH-H2O (v/v=1:9, pH=6) by forming a 1:1 complex with Al(3+) and the detection limit of QC for Al(3+) was as low as 0.012μM. Furthermore, these results displayed that the binding of QCAl(3+) was broken by F(-), so this system could be used to monitor F(-) in the future...
September 8, 2017: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/28917090/oleanane-triterpenes-with-protein-tyrosine-phosphatase-1b-inhibitory-activity-from-aerial-parts-of-lantana-camara-collected-in-indonesia-and-japan
#7
Delfly B Abdjul, Hiroyuki Yamazaki, Wilmar Maarisit, Henki Rotinsulu, Defny S Wewengkang, Deiske A Sumilat, Magie M Kapojos, Fitje Losung, Kazuyo Ukai, Michio Namikoshi
During the search for new protein tyrosine phosphatase (PTP) 1B inhibitors, EtOH extracts from the aerial parts of Lantana camara L. (lantana) collected at Manado (Indonesia) and two subtropical islands in Japan (Ishigaki and Iriomote Islands, Okinawa) exhibited potent inhibitory activities against PTP1B in an enzyme assay. Four previously undescribed oleanane triterpenes were isolated together with known triterpenes and flavones from the Indonesian lantana. The EtOH extracts of lantana collected in Ishigaki and Iriomote Islands exhibited different phytochemical profiles from each other and the Indonesian lantana...
September 13, 2017: Phytochemistry
https://www.readbyqxmd.com/read/28912875/inhibitory-effect-of-burdock-leaves-on-elastase-and-tyrosinase-activity
#8
Chi-Ting Horng, Hsing-Chen Wu, Ni-Na Chiang, Chiu-Fang Lee, Yu-Syuan Huang, Hui-Yun Wang, Jai-Sing Yang, Fu-An Chen
Burdock (Arctium lappa L.) leaves generate a considerable amount of waste following burdock root harvest in Taiwan. To increase the use of burdock leaves, the present study investigated the optimal methods for producing burdock leaf extract (BLE) with high antioxidant polyphenolic content, including drying methods and solvent extraction concentration. In addition, the elastase and tyrosinase inhibitory activity of BLE was examined. Burdock leaves were dried by four methods: Shadow drying, oven drying, sun drying and freeze-drying...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28912059/piracetam-inhibits-ethanol-etoh-induced-memory-deficit-by-mediating-multiple-pathways
#9
Yifan Yang, Jian Feng, Fangyuan Xu, Jianglin Wang
Excessive ethanol (EtOH) intake, especially to prenatal exposure, can significantly affect cognitive function and cause permanent learning and memory injures in children. As a result, how to protect children from EtOH neurotoxicity has gained increasing attention in recent years. Piracetam (Pir) is a nootropic drug derived from c-aminobutyric acid and can manage cognition impairments in multiple neurological disorders. Studies have shown that Pir can exert therapeutic effects on EtOH-induced memory impairments, but the underlying mechanism is still unknown...
September 11, 2017: Brain Research
https://www.readbyqxmd.com/read/28911849/eight-new-phenylethanoid-glycoside-derivatives-possessing-potential-hepatoprotective-activities-from-the-fruits-of-forsythia-suspensa
#10
Si-Yuan Shao, Zi-Ming Feng, Ya-Nan Yang, Jian-Shuang Jiang, Pei-Cheng Zhang
In our study to investigate components with hepatoprotective activities, eight new phenylethanoid glycoside derivatives (1-8) were isolated from the 75% EtOH-H2O extract of the fruits of Forsythia suspensa along with six known compounds (9-14). These new structures were elucidated through HRESIMS and extensive NMR spectroscopic techniques. The absolute configurations of their sugars were determined by GC analysis. The pharmacological assay showed that compounds 2, 3, and 9-11 displayed remarkable hepatoprotective activities against N-acetyl-p-aminophenol (APAP)-induced HepG2 cell damage at the concentration of 10μM (Bicyclol as positive contrast)...
September 11, 2017: Fitoterapia
https://www.readbyqxmd.com/read/28899481/cal-b-catalyzed-deacylation-of-benzylic-acetates-effect-of-amines-addition-comparison-of-several-approaches
#11
Mounia Merabet-Khelassi, Amna Zaidi, Louisa Aribi-Zouioueche
Herein, we report an efficient enantioselective cleavage of the acyl-moity of some secondary benzylic acetate derivatives catalyzed by lipase B from Candida antarctica (CAL-B) in the presence of triethylamine, as additive, in non aqueous media. The influence of the hydrophobicity of two solvent, the basicity of three amines and the amount of CAL-B were studied in the presence/absence of molecular sieves 4Å. The best results in term of selectivity are achieved using the triethylamine as basic additive and in that case, the reactivity is only best at low conversion...
December 2017: Enzyme and Microbial Technology
https://www.readbyqxmd.com/read/28894190/novel-detection-of-post-translational-modifications-in-human-monocyte-derived-dendritic-cells-after-chronic-alcohol-exposure-role-of-inflammation-regulator-h4k12ac
#12
Tiyash Parira, Gloria Figueroa, Alejandra Laverde, Gianna Casteleiro, Mario E Gomez Hernandez, Francisco Fernandez-Lima, Marisela Agudelo
Previous reports on epigenetic mechanisms involved in alcohol abuse have focus on hepatic and neuronal regions, leaving the immune system and specifically monocyte-derived dendritic cells (MDDCs) understudied. Our lab has previously shown histone deacetylases are modulated in cells derived from alcohol users and after in vitro acute alcohol treatment of human MDDCs. In the current study, we developed a novel screening tool using matrix assisted laser desorption ionization-fourier transform-ion cyclotron resonance mass spectrometry (MALDI-FT-ICR MS) and single cell imaging flow cytometry to detect post-translational modifications (PTMs) in human MDDCs due to chronic alcohol exposure...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28889931/isolation-and-antifungal-activity-evaluation-of-satureja%C3%A2-khuzestanica-jamzad-extract-against-some-clinically-important-dermatophytes
#13
B Sadeghi-Nejad, A Rezaei-Matehkolaei, S Yusef Naanaie
Among the fungi, dermatophytes are the major cause of spectrum of superficial mycoses medically known as dermatophytosis (tinea) in human and animal. Treatment of these infections has still remained difficult. The aim of this survey was to evaluate in vitro anti-dermatophytic activity of ethanolic extract (EtOH) from Satureja khuzestanica leaf (SKLE) against some clinically important dermatophyte species from the genera of Trichophyton, Microsporum and Epidermophyton. Minimal inhibition concentration (MIC) of SKLE was tested against 14 dermatophyte strains of 5 species by using agar dilution method...
September 7, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28887712/higher-incidence-of-pancreatic-fistula-in-laparoscopic-gastrectomy-real-world-evidence-from-a-nationwide-prospective-cohort-study
#14
Naoki Hiki, Michitaka Honda, Tsuyoshi Etoh, Kazuhiro Yoshida, Yasuhiro Kodera, Yoshihiro Kakeji, Hikaru Kumamaru, Hiroaki Miyata, Yuichi Yamashita, Masafumi Inomata, Hiroyuki Konno, Yasuyuki Seto, Seigo Kitano
BACKGROUND: Laparoscopic distal gastrectomy (LDG) is becoming the standard procedure for gastric cancer. However, supporting evidence thus far has been derived primarily from randomized control trials conducted by centers of excellence. In the present study we used the National Clinical Database (NCD) in Japan to prospectively accumulate data from diverse types of hospitals and examine whether LDG is a safe and valid standard procedure. METHODS: From the NCD, 169 institutions were selected to form a cohort that was considered to be representative of Japan...
September 8, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/28886514/fabrication-of-polymer-matrix-free-nanocomposites-based-on-angelica-gigas-nakai-extract-and-their-application-to-breast-cancer-therapy
#15
Song Yi Lee, Jeong-Jun Lee, Suyeong Nam, Wie-Soo Kang, In-Soo Yoon, Hyun-Jong Cho
Nanocomposites (NCs) based on the ethanol extract of Angelica gigas Nakai (AGN EtOH ext) were developed for breast cancer therapy. Polymer matrix-free nano-sized particles based on the extract of natural product were fabricated using a modified emulsification-solvent evaporation method. Without the use of polymer matrix, toxicity can be minimized and the clinical application may be assured. AGN NCs with approximately 200nm mean diameter, narrow size distribution, and negative zeta potential were prepared in this study...
August 26, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28880090/thermoresponsive-stability-of-colloids-in-butyl-acetate-ethanol-binary-solvent-realized-by-grafting-linear-acrylate-copolymers
#16
Lu Jin, Jonas Bemetz, Xia Meng, Hua Wu, Massimo Morbidelli
We have developed a new class of thermoresponsive colloids that can exhibit a sharp reversible transition between dispersion and aggregation in binary BuAc/EtOH solvents based on the UCST (upper critical solution temperature)-type phase separation. This is realized by grafting linear PMMA-BA (random) copolymer onto the colloidal particles. We have selected TiO2/PS hybrid spheres (HSs) as a model system to demonstrate our general design concept. By grafting the linear PMMA-BA copolymer onto the HS surface, with the molecular weight from 30 to 40 kDa, we found that the thermoresponsive transition between dispersion and aggregation is fast, sharp, and reversible...
September 7, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28876916/molecular-routes-to-group-iv-magnesium-and-calcium-nanocrystalline-ceramics
#17
Rafał Petrus, Anna Drąg-Jarząbek, Józef Utko, Dominik Bykowski, Tadeusz Lis, Piotr Sobota
The effect of alkaline-earth-metal alkoxides on the protonolysis of Cp2M'Cl2 (M' = Ti, Zr, Hf; Cp = cyclopentadiene) was investigated. This approach enabled the design of compounds with well-defined molecular structures to generate high-purity binary metal oxides. Single-source molecular precursors with structures of [M2M'2(μ3-OEt)2(μ-OEt)4(OEt)6(EtOH)4] with M = Mg and M' = Ti (1), Zr (2), and Hf (3), [Ca6Ti4(μ6-O)2(μ4-O)2(μ3-OEt)12(OEt)12(EtOH)6Cl4] (4), and [M2M'2(μ4-O)(μ-OEt)5(OEt)4(EtOH)4Cl]n with M = Ca and M' = Zr (5) and Hf (6) were prepared via elimination of the cyclopentadienyl ring from Cp2M'Cl2 as CpH in the presence of M(OEt)2 and ethanol (EtOH) as a source of protons...
September 6, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28867749/nanoemulsion-a-suitable-nanodelivery-system-of-clove-oil-for-anesthetizing-nile-tilapia
#18
Kantaporn Kheawfu, Surachai Pikulkaew, Wasana Chaisri, Siriporn Okonogi
Clove oil ethanolic solution (CL-EtOH) have always been used for fish anesthesia. However, ethanol causes major side effect of fish hypersensivity. In this study, clove oil loaded nanoemulsion (CLN) was developed in order to enhance water miscibility of clove oil without using ethanol in the preparations. The obtained CLN was characterized in terms of droplet size, size distribution expressed as polydispersity index (PDI), and zeta potential. The anesthetic effect of CLN in comparison with CL-EtOH on Oreochromis niloticus (Nile tilapia) was investigated...
2017: Drug Discoveries & Therapeutics
https://www.readbyqxmd.com/read/28865617/development-of-new-green-processes-for-the-recovery-of-bioactives-from-phaeodactylum-tricornutum
#19
Bienvenida Gilbert-López, Almudena Barranco, Miguel Herrero, Alejandro Cifuentes, Elena Ibáñez
Two novel extraction techniques, pressurized liquid extraction (PLE) and microwave-assisted solvent extraction (MAE) have been evaluated for the recovery of bioactive compounds from Phaeodactylum tricornutum. Microalga P. tricornutum is rich in polyunsaturated fatty acids (PUFAs), such as EPA, and has a high content of the carotenoid fucoxanthin, which is a valuable pigment with several biological activities. Cells were disrupted at high pressure and then freeze-dried as a previous step to extraction. Additionally, only green solvents as water and ethanol (EtOH) - and mixtures of them - were used...
September 2017: Food Research International
https://www.readbyqxmd.com/read/28856500/methamphetamine-induced-brain-injury-and-alcohol-drinking
#20
Amanda L Blaker, Bryan K Yamamoto
A majority of methamphetamine (Meth) abusers also abuse alcohol but the neurochemical consequences of this co-abuse are unknown. Individually, alcohol and Meth cause inflammation and long-term alterations in dopamine and serotonin signaling within the brain. Experiments were conducted to identify if serial exposure to alcohol and Meth has neurochemical consequences that are greater than after either drug alone. Male Sprague Dawley rats voluntarily drank 10% ethanol (EtOH) every other day for 4 weeks and were then exposed to a binge injection regimen of Meth (10 mg/kg injected every 2 h, for a total of 4 injections)...
August 30, 2017: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
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