Flavie Bompaire, Marion Lahutte, Stephane Buffat, Carole Soussain, Anne Emmanuelle Ardisson, Robert Terziev, Magali Sallansonnet-Froment, Thierry De Greslan, Sébastien Edmond, Mehdi Saad, Christophe Nioche, Thomas Durand, Sonia Alamowitch, Khe Hoang Xuan, Jean Yves Delattre, Jean Luc Renard, Hervé Taillia, Cyrus Chargari, Dimitri Psimaras, Damien Ricard
BACKGROUND: Radiation-induced leukoencephalopathy (RIL) is the most threatening delayed complication of cerebral radiotherapy (RT) and remains roughly defined by cognitive dysfunction associated with diffuse FLAIR MRI white matter hyperintensities after brain irradiation. We documented clinical, neuropsychological, and radiological aspects of RI in order to refine diagnostic criteria. METHODS: Patients referred to our center for deterioration in cognitive complaint at least 6 months after completing a focal or whole brain RT underwent a systematic cross-sectional assessment including clinical examination, neuropsychological tests, and a standardized MRI protocol...
December 2018: Supportive Care in Cancer