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https://www.readbyqxmd.com/read/29611821/galectin-9-inhibits-tlr7-mediated-autoimmunity-in-murine-lupus-models
#1
Santosh K Panda, Valeria Facchinetti, Elisaveta Voynova, Shino Hanabuchi, Jodi L Karnell, Richard N Hanna, Roland Kolbeck, Miguel A Sanjuan, Rachel Ettinger, Yong-Jun Liu
Uncontrolled secretion of type I IFN, as the result of endosomal TLR (i.e., TLR7 and TLR9) signaling in plasmacytoid DCs (pDCs), and abnormal production of autoantibodies by B cells are critical for systemic lupus erythematosus (SLE) pathogenesis. The importance of galectin-9 (Gal-9) in regulating various autoimmune diseases, including lupus, has been demonstrated. However, the precise mechanism by which Gal-9 mediates this effect remains unclear. Here, using spontaneous murine models of lupus (i.e., BXSB/MpJ and NZB/W F1 mice), we demonstrate that administration of Gal-9 results in reduced TLR7-mediated autoimmune manifestations...
April 3, 2018: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29593732/a-distinct-t-follicular-helper-cell-subset-infiltrates-the-brain-in-murine-neuropsychiatric-lupus
#2
Shweta Jain, Ariel Stock, Fernando Macian, Chaim Putterman
Neuropsychiatric symptoms in systemic lupus erythematosus (SLE) are not uncommon, yet the mechanisms underlying disease initiation and progression in the brain are incompletely understood. Although the role of T cells in other lupus target organs such as the kidney is well defined, which T cells contribute to the pathogenesis of neuropsychiatric SLE is not known. The present study was aimed at characterizing the CD4 T cell populations that are present in the choroid plexus (CP) of MRL/MpJ-fas lpr mice, the primary site of brain infiltration in this classic lupus mouse model which exhibits a prominent neurobehavioral phenotype...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29590230/duration-of-type-2-diabetes-is-a-predictor-of-elevated-plantar-foot-pressure
#3
Brooke Falzon, Cynthia Formosa, Liberato Camilleri, Alfred Gatt
AIMS: Elevated plantar pressure is considered a significant risk factor for ulceration in diabetes mellitus. The aim of this study was to determine whether duration of diabetes could affect plantar pressure in patients with no known significant comorbidity or foot pathology. METHODS: Participants with type 2 diabetes, but without known confounding factors that could alter peak pressure, were matched for age, weight, and gender and categorized into 3 groups of diabetes duration: group 1 (1-5 yr), group 2 (6-10 yr), and group 3 (11-15 yr)...
2018: Review of Diabetic Studies: RDS
https://www.readbyqxmd.com/read/29405701/maskless-hydrophilic-patterning-of-superhydrophobic-aluminum-surface-by-atmospheric-pressure-micro-plasma-jet-for-water-adhesion-controlling
#4
Jiyu Liu, Jinlong Song, Guansong Wang, Faze Chen, Shuo Liu, Xiaolong Yang, Jing Sun, Huanxi Zheng, Liu Huang, Zhuji Jin, Xin Liu
Superhydrophobic surfaces with hydrophilic patterns have great application potential in various fields, such as microfluidic systems and water harvesting. However, many reported preparation methods involve complicated devices and/or masks, making fabrication of these patterned surfaces time-consuming and inefficient. Here, we propose a high-efficient, simple and maskless micro-plasma jet (MPJ) treatment method to prepare hydrophilic patterns like dots, lines and curves on superhydrophobic Al substrates. Contact angles, sliding angles, adhesive forces and droplet impact behavior of the created patterns are investigated and analyzed...
February 6, 2018: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29383850/adoptive-transfer-of-cd3-t-cells-and-cd4-cd44high-memory-t-cells-induces-autoimmune-pancreatitis-in-mrl-mpj-mice
#5
Luise Ehlers, Sarah Rohde, Saleh Ibrahim, Robert Jaster
The immunopathogenesis of autoimmune pancreatitis (AIP) is poorly understood. Here, we have used MRL/MpJ mice, a model of spontaneous AIP, to address the role of cellular autoimmune processes in the initiation and progression of the disease. Therefore, different T cell subpopulations were adoptively transferred from sick to still healthy (but susceptible) MRL/MpJ mice. Unpurified splenocytes and CD3+ T cells both efficiently induced AIP, while CD4+ and CD8+ T cells alone, as well as splenocytes from healthy mice, were insufficient to trigger the disease...
January 31, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29312840/relationship-between-the-intersesamoid-ligament-and-sesamoid-bones-in-cadaveric-feet-with-hallux-valgus
#6
Regina C Fiacco, Garen M Ream, Charlotte Wilson, R Shane Tubbs, Marios Loukas, Piotr B Kozlowski, Anthony C DiLandro, Kevin T Jules, Anthony V D'Antoni
There is heterogeneity in the literature regarding the anatomy, exact location, and definition of the intersesamoid ligament (IL). Anatomic knowledge of the IL and its variations are important for surgeons who undertake corrective surgery for hallux abducto valgus (HAV). The IL was dissected in 16 feet from 32 formalin-fixed cadavers (12 females, four males; mean age at death, 76.6 years) to examine its morphology. The length, width, and thickness of its constituent bands were recorded with a digital caliper...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29240238/evaluation-of-microfiltration-and-heat-treatment-on-the-microbiological-characteristics-phenolic-composition-and-volatile-compound-profile-of-pomegranate-punica-granatum-l-juice
#7
Antonio Colantuono, Paola Vitaglione, Nadia Manzo, Giuseppe Blaiotta, Immacolata Montefusco, Andrea Marrazzo, Fabiana Pizzolongo, Raffaele Romano
BACKGROUND: Since processing technology and storage may influence the sensory and nutritional value as well as the shelf life of pomegranate juice (PJ), mild technologies based on microfiltration may be a promising alternative to heat treatments for fruit juice preservation. In this study, physicochemical and microbiological properties of raw (RPJ), microfiltered (MPJ) and cloudy pasteurized (PPJ) PJ were compared over a period of 4 weeks. RESULTS: Data demonstrated that microfiltration was comparable to pasteurization in guaranteeing microbiological stability of the juice, avoiding spoilage of the final product...
December 14, 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/29194431/characteristics-of-plantar-loads-during-walking-in-patients-with-knee-osteoarthritis
#8
Zhiwang Zhang, Lin Wang, Kaijun Hu, Yu Liu
BACKGROUND Knee osteoarthritis (KOA) is a common disease that can change the load on lower limbs during walking. Plantar loads in patients with KOA may provide a basis for clinical decisions regarding footwear and foot orthoses. This study aimed to compare plantar loads in females with and without KOA during gait. MATERIAL AND METHODS Plantar pressure during walking was recorded in 23 females with KOA and 23 females without KOA. Maximum force (MF), contact area (CA), and peak pressure (PP) were measured at 7 different regions underneath the foot, named heel (M1), midfoot (M2), first metatarsophalangeal joint (MPJ) (M3), second MPJ (M4), third to fifth MPJ (M5), hallux (M6), and lesser toes (M7)...
December 1, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/29167408/conjugated-linoleic-acid-prevents-age-dependent-neurodegeneration-in-a-mouse-model-of-neuropsychiatric-lupus-via-the-activation-of-an-adaptive-response
#9
Antonio Monaco, Ida Ferrandino, Floriana Boscaino, Ennio Cocca, Luisa Cigliano, Francesco Maurano, Diomira Luongo, Maria Stefania Spagnuolo, Mauro Rossi, Paolo Bergamo
Oxidative stress is a key mediator of autoimmune/neurodegenerative disorders. The antioxidant/anti-inflammatory effect of a synthetic conjugated linoleic acid (CLA) mixture in MRL/MpJ-Fas lpr mice (MRL/ lpr ), an animal model of neuropsychiatric lupus, was previously associated with the improvement of nuclear factor-E2-related factor 2 (Nrf2) defenses in the spleen and liver. However, little is known about the neuroprotective ability of a CLA mixture. This study investigated the age-dependent progression of oxidative stress and the hyperactivation of redox-sensitive compensatory pathways (macroautophagy, Nrf2) in old/diseased MRL/ lpr mice brains and examines the effect produced by dietary CLA supplementation...
January 2018: Journal of Lipid Research
https://www.readbyqxmd.com/read/29116018/tissue-specific-role-of-rhbdf2-in-cutaneous-wound-healing-and-hyperproliferative-skin-disease
#10
Vishnu Hosur, Bonnie L Lyons, Lisa M Burzenski, Leonard D Shultz
OBJECTIVE: Gain-of-function (GOF) mutations in RHBDF2 cause tylosis. Patients present with hyperproliferative skin, and keratinocytes from tylosis patients' skin show an enhanced wound-healing phenotype. The curly bare mouse model of tylosis, carrying a GOF mutation in the Rhbdf2 gene (Rhbdf2cub ), presents with epidermal hyperplasia and shows accelerated cutaneous wound-healing phenotype through enhanced secretion of the epidermal growth factor receptor family ligand amphiregulin. Despite these advances in our understanding of tylosis, key questions remain...
November 7, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29039226/reconstruction-of-traumatic-dorsal-loss-of-the-thumb-four-different-surgical-approaches
#11
Roberto Adani, Raffaele Mugnai, Giovanna Petrella
BACKGROUND: This article outlines our methods for thumb reconstruction following dorsal skin loss injury located between the metacarpophalangeal joint (MPj) and the entire nail affecting skin, nail, tendon, and bone in different combinations but with intact sensate palmar skin. METHODS: Between 1990 and 2015, 24 patients were treated for dorsal thumb defects using 4 different surgical techniques. Five cases of dorsal compound traumatic loss were reconstructed by custom-made dorsal great toe transfer...
October 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28936588/technical-details-and-results-of-a-modified-end-to-side-technique-of-pancreatojejunostomy-a-personal-series-of-100-patients
#12
Luca Morelli, Gregorio Di Franco, Simone Guadagni, Matteo Palmeri, Niccolò Furbetta, Desirée Gianardi, Marco Del Chiaro, Giulio Di Candio, Franco Mosca
BACKGROUND: The treatment of pancreatic stump is a critical step of pancreatoduodenectomy (PD) because leaks from this anastomosis incur major morbidity and mortality. We describe the technical details of a modified end-to-side pancreatojejunostomy (mPJ), and report on the outcome of the first 100 patients. METHODS: From October 2008 to June 2017, 424 pancreatic resections were performed, of which 203 were PD. The mPJ was introduced in November 2010 and used in 100 consecutive patients, by a single surgeon...
December 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28934385/hearing-loss-without-overt-metabolic-acidosis-in-atp6v1b1-deficient-mrl-mice-a-new-genetic-model-for-non-syndromic-deafness-with-enlarged-vestibular-aqueducts
#13
Cong Tian, Leona H Gagnon, Chantal Longo-Guess, Ron Korstanje, Susan M Sheehan, Kevin K Ohlemiller, Angela D Schrader, Jaclynn M Lett, Kenneth R Johnson
Mutations of the human ATP6V1B1 gene cause distal renal tubular acidosis (dRTA; OMIM #267300) often associated with sensorineural hearing impairment; however, mice with a knockout mutation of Atp6v1b1 were reported to exhibit a compensated acidosis and normal hearing. We discovered a new spontaneous mutation (vortex, symbol vtx) of Atp6v1b1 in an MRL/MpJ (MRL) colony of mice. In contrast to the reported phenotype of the knockout mouse, which was developed on a primarily C57BL/6 (B6) strain background, MRL-Atp6v1b1vtx/vtx mutant mice exhibit profound hearing impairment, which is associated with enlarged endolymphatic compartments of the inner ear...
October 1, 2017: Human Molecular Genetics
https://www.readbyqxmd.com/read/28906016/cxcl10-is-upregulated-in-synovium-and-cartilage-following-articular-fracture
#14
Bridgette D Furman, Collin L Kent, Janet L Huebner, Virginia B Kraus, Amy L McNulty, Farshid Guilak, Steven A Olson
The objective of this study was to investigate the expression of the chemokine CXCL10 and its role in joint tissues following articular fracture. We hypothesized that CXCL10 is upregulated following articular fracture and contributes to cartilage degradation associated with post-traumatic arthritis (PTA). To evaluate CXCL10 expression following articular fracture, gene expression was quantified in synovial tissue from knee joints of C57BL/6 mice that develop PTA following articular fracture, and MRL/MpJ mice that are protected from PTA...
September 14, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/28870174/local-cd34-positive-capillaries-decrease-in-mouse-models-of-kidney-disease-associating-with-the-severity-of-glomerular-and-tubulointerstitial-lesions
#15
Md Abdul Masum, Osamu Ichii, Yaser Hosny Ali Elewa, Teppei Nakamura, Yasuhiro Kon
BACKGROUND: The renal vasculature plays important roles in both homeostasis and pathology. In this study, we examined pathological changes in the renal microvascular in mouse models of kidney diseases. METHODS: Glomerular lesions (GLs) in autoimmune disease-prone male BXSB/MpJ-Yaa (Yaa) mice and tubulointerstitial lesions (TILs) in male C57BL/6 mice subjected to unilateral ureteral obstruction (UUO) for 7 days were studied. Collected kidneys were examined using histopathological techniques...
September 4, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28800777/bortezomib-treatment-induces-a-higher-mortality-rate-in-lupus-model-mice-with-a-higher-disease-activity
#16
Tomoko Ikeda, Hiroshi Fujii, Masato Nose, Yukiko Kamogawa, Tsuyoshi Shirai, Yuko Shirota, Tomonori Ishii, Hideo Harigae
BACKGROUND: Bortezomib (Bz) is a proteasome inhibitor that directly targets antibody-producing plasma cells. We recently reported the first randomized control trial that evaluated the effects of Bz in patients with systemic lupus erythematosus (SLE). In that study, we demonstrated that Bz treatment is associated with many adverse reactions in patients with refractory disease. In the present study, we examine the therapeutic and toxic effects of Bz on MRL/MpJ-lpr/lpr (MRL/lpr) mice with severe disease activity...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28758427/genome-wide-dna-methylation-profiling-of-the-regenerative-mrl-mpj-mouse-and-two-normal-strains
#17
Bartosz Górnikiewicz, Anna Ronowicz, Piotr Madanecki, Paweł Sachadyn
AIM: We aimed to identify the pivotal differences in the DNA methylation profiles between the regeneration capable MRL/MpJ mouse and reference mouse strains. MATERIALS & METHODS: Global DNA methylation profiling was performed in ear pinnae, bone marrow, spleen, liver and heart from uninjured adult females of the MRL/MpJ and C57BL/6J and BALB/c. RESULTS & CONCLUSION: A number of differentially methylated regions (DMRs) distinguishing between the MRL/MpJ mouse and both references were identified...
July 31, 2017: Epigenomics
https://www.readbyqxmd.com/read/28665157/sex-related-differences-in-autoimmune-induced-lung-lesions-in-mrl-mpj-fas-lpr-mice-are-mediated-by-the-development-of-mediastinal-fat-associated-lymphoid-clusters
#18
Yaser Hosny Ali Elewa, Osamu Ichii, Yasuhiro Kon
MRL/MpJ-Faslpr (lpr) mice are a model for autoimmune diseases such as systemic lupus erythematosus (SLE). These diseases mainly affect women, with a 10:1 female-to-male ratio, and cause pleuropulmonary lesions. We previously revealed a correlation between mediastinal fat-associated lymphoid cluster (MFALC) development and cellular infiltration in the lungs of lpr male mice; however, we did not report on MFALCs in females. The purpose of this investigation was to reveal sex-related differences in MFALCs in lpr mice...
August 2017: Autoimmunity
https://www.readbyqxmd.com/read/28566018/autoimmune-abnormality-affects-ovulation-and-oocyte-pick-up-in-mrl-mpj-fas-lpr-lpr-mice
#19
M Hosotani, O Ichii, T Nakamura, S O Kanazawa, Y Hosny Ali Elewa, Y Kon
Ovulation and oocyte-pick-up are essential processes in fertilization. Herein, we found associations between autoimmune disease and the aforementioned processes in mice. At three and six months, along with the evaluation of autoimmune disease indices, the ovary, mesosalpinx, and oviducts were histologically examined in C57BL/6, MRL/MpJ, and MRL/MpJ-Faslpr/lpr mice as healthy control, mild and severe models of autoimmune disease, respectively. In superovulated mice, the number of "oocyte cumulus complexes" found in the ampulla was macroscopically counted, and that of "ovulated oocytes" was histologically evaluated, as indicated by ruptured follicles or corpora hemorrhagica in ovaries...
January 2018: Lupus
https://www.readbyqxmd.com/read/28530484/in-vivo-geometry-of-the-kissing-stent-and-covered-endovascular-reconstruction-of-the-aortic-bifurcation-configurations-in-aortoiliac-occlusive-disease
#20
MULTICENTER STUDY
Erik Groot Jebbink, Thijs G Ter Mors, Cornelis H Slump, Robert H Geelkerken, Suzanne Holewijn, Michel Mpj Reijnen
Objectives Various configurations of kissing stent (KS) configurations exist and patency rates vary. In response the covered endovascular reconstruction of the aortic bifurcation configuration was designed to minimize mismatch and improve outcome. The aim of the current study is to compare geometrical mismatch of kissing stent with the covered endovascular reconstruction of the aortic bifurcation configuration in vivo. Methods Post-operative computed tomographic data and patient demographics from 11 covered endovascular reconstruction of the aortic bifurcation and 11 matched kissing stent patients were included...
December 2017: Vascular
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