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metastases for colorectal cancer

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https://www.readbyqxmd.com/read/29145106/metachronous-mediastinal-lymph-node-metastasis-from-ascending-colon-cancer-a-case-report-and-literature-review
#1
Kosuke Toda, Kenji Kawada, Yoshiharu Sakai, Hiroshi Izumi
INTRODUCTION: Metachronous mediastinal lymph node metastasis without pulmonary metastasis is extremely rare in colorectal cancer, which makes the clinical diagnosis difficult and treatment strategy unclear. PRSENTATION OF CASE: A case was a 59-year-old man, who had undergone right hemicolectomy for ascending colon cancer 2 years and 8 months previously, presented with enlarged mediastinal lymph nodes. (18)F-fluorodeoxyglucose (FDG) positron emission tomography revealed FDG was accumulated only into the mediastinal lymph nodes...
November 9, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29133238/mir-146a-targets-c-met-and-abolishes-colorectal-cancer-liver-metastasis
#2
Anne-Marie Bleau, Miriam Redrado, Estanislao Nistal-Villan, Maria Villalba, Francisco Exposito, Esther Redin, Arrate L de Aberasturi, Leyre Larzabal, Javier Freire, Javier Gomez-Roman, Alfonso Calvo
A major complication of colorectal cancer (CRC), one of the most frequent and deadly types of cancer, is disease progression via liver metastases. At this stage, very few treatment options are available for patients, and the disease remains incurable. Herein, we used a well-established mouse model of CRC liver metastasis (CLM) to identify new regulators of this process. Using serial transplantation of murine MC38 adenocarcinoma cells, we obtained liver metastatic variants that displayed extremely strong colonization abilities...
November 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29131348/the-value-of-contrast-enhanced-laparoscopic-ultrasound-during-robotic-assisted-surgery-for-primary-colorectal-cancer
#3
Signe Bremholm Ellebaek, Claus Wilki Fristrup, Torsten Pless, Peiman Hossein Poornoroozy, Per Vadgaard Andersen, Bassam Mahdi, Michael Bau Mortensen
AIM: The aim of this study was to assess the potential clinical value of contrast enhanced laparoscopic ultrasonography (CE-LUS) as a screening modality for liver metastases during robotic assisted surgery for primary colorectal cancer (CRC). METHOD: A prospective, descriptive (feasibility) study including 50 consecutive patients scheduled for robotic assisted surgery for primary CRC. CE-LUS was performed by 2 experienced specialists. Only patients without metastatic disease were included...
November 13, 2017: Journal of Clinical Ultrasound: JCU
https://www.readbyqxmd.com/read/29130628/characterization-of-genetic-intratumor-heterogeneity-in-colorectal-cancer-and-matching-patient-derived-spheroid-cultures
#4
Sigrid Salling Árnadóttir, Maria Jeppesen, Philippe Lamy, Jesper Bertram Bramsen, Iver Nordentoft, Michael Knudsen, Søren Vang, Mogens Rørbaek Madsen, Ole Thastrup, Jacob Thastrup, Claus Lindbjerg Andersen
Patient-derived in vitro cultures of colorectal cancer (CRC) may help guide treatment strategies prior to patient treatment. However, most previous studies have been performed on a single biopsy per tumor. The purpose of this study was to analyze multiple spatially distinct biopsies from CRCs and see how well intratumor heterogeneity (ITH) was recapitulated in matching patient-derived spheroids. Three to five biopsies were collected from six CRC tumors. Each biopsy was split in two; one half was used for spheroid culturing, the other half was used for DNA and RNA purification...
November 11, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/29125233/in-vivo-imaging-xenograft-models-for-the-evaluation-of-anti-brain-tumor-efficacy-of-targeted-drugs
#5
Kenji Kita, Sachiko Arai, Akihiro Nishiyama, Hirokazu Taniguchi, Koji Fukuda, Rong Wang, Tadaaki Yamada, Shinji Takeuchi, Shoichiro Tange, Atsushi Tajima, Mitsutoshi Nakada, Kazuo Yasumoto, Yoshiharu Motoo, Takashi Murakami, Seiji Yano
Molecular-targeted drugs are generally effective against tumors containing driver oncogenes, such as EGFR, ALK, and NTRK1. However, patients harboring these oncogenes frequently experience a progression of brain metastases during treatment. Here, we present an in vivo imaging model for brain tumors using human cancer cell lines, including the EGFR-L858R/T790M-positive H1975 lung adenocarcinoma cells, the NUGC4 hepatocyte growth factor (HGF)-dependent gastric cancer cells, and the KM12SM colorectal cancer cells containing the TPM3-NTRK1 gene fusion...
November 10, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29124480/a-case-of-napsin-a-positive-metastatic-lung-cancer-originating-from-the-colon
#6
Tomokazu Ito, Kozo Nakanishi, Hidenori Goto
BACKGROUND: We report a case of napsin A-positive metastatic lung cancer originating from the colon. No cases of napsin A-positive metastatic lung tumors originating from colorectal cancer have been reported previously. CASE PRESENTATION: Computed tomography identified a small lung nodule in a 70-year-old male patient, 18 months after resection for rectal cancer. The size of the lung tumor increased from 1.8 to 2.1 cm in 6 months and metastasis from the rectal cancer was suspected...
November 9, 2017: Surgical Case Reports
https://www.readbyqxmd.com/read/29124419/a-systematic-review-to-assess-the-management-of-patients-with-cerebral-metastases-secondary-to-colorectal-cancer
#7
REVIEW
I L Silva, M Iskandarani, A Hotouras, J Murphy, C Bhan, B Adada, S D Wexner
BACKGROUND: Colorectal cancer (CRC) rarely metastasizes to the brain. The incidence of cerebral metastases (CM) is estimated between 1 and 3%. Given the improved survival from advanced CRC as a result of surgical and oncological advances, it is anticipated that the incidence of patients with CM from CRC will rise over the next few years. The aim of this article was to systematically review the treatment options and outcome of patients with CM from CRC. METHODS: PubMed and Medline databases were examined using the search words or MESH headings "colorectal" "cancer/carcinoma/adenocarcinoma", "cerebral"/"brain" and "metastases/metastasis"...
November 9, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/29120905/fluorine-18-fluorodeoxyglucose-uptake-of-bone-marrow-on-pet-ct-can-predict-prognosis-in-patients-with-colorectal-cancer-after-curative-surgical-resection
#8
Jeong Won Lee, Moo-Jun Baek, Tae Sung Ahn, Sang Mi Lee
OBJECTIVE: This study investigated the relationship of fluorine-18-fluorodeoxyglucose (F-FDG) uptake of bone marrow (BM) on PET/computed tomography (PET/CT) with clinicopathologic factors and survival in patients with colorectal cancer. PATIENTS AND METHODS: The study retrospectively included 226 patients with colorectal cancer who underwent F-FDG PET/CT for staging workup and treated with curative surgical resection. The maximum F-FDG uptake of primary cancer (Tmax) and mean F-FDG uptake of BM [BM standardized uptake value (SUV)] were derived from PET/CT images...
November 8, 2017: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29119054/mir-216b-functions-as-a-tumor-suppressor-by-targeting-hmgb1-mediated-jak2-stat3-signaling-way-in-colorectal-cancer
#9
Xiaoxiang Chen, Xiangxiang Liu, Bangshun He, Yuqin Pan, Huiling Sun, Tao Xu, Xiuxiu Hu, Shukui Wang
MiR-216b is implicated in the development of multiple types of cancers, however, a role for miR-216b in colorectal cancer (CRC) remains elusive. The present study aimed to investigate the function and underlying mechanism of miR-216b in human CRC. In this study, we found miR-216b in CRC tissues and cell lines was markedly decreased compared with corresponding adjacent normal tissues (ANTs) and colonic mucosal epithelial cell line (FHC), and was obviously associated with the TNM stage, lymph node metastases, differentiation and poor overall survival (OS) (P<0...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/29119017/pulmonary-metastasectomy-an-overview
#10
REVIEW
Francesco Petrella, Cristina Diotti, Arianna Rimessi, Lorenzo Spaggiari
Metastasectomy is the most frequent surgical resection undertaken by thoracic surgeons, being the lung the second common site of metastases. The present oncological criteria for pulmonary metastasectomy are: (I) the primary cancer need to be controlled or controllable; (II) no extrathoracic metastasis-that is not controlled or controllable-exists; (III) all of the tumor must be resectable, with adequate pulmonary reserve; (IV) there are no alternative medical treatment options with lower morbidity. General favourable prognostic features in patients with pulmonary metastases are: (I) one or few metastases; (II) long disease free interval; (III) normal CEA levels in colorectal cancers...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29119016/pulmonary-metastasectomy-for-colorectal-cancer-analysis-of-prognostic-factors-affecting-survival
#11
Luca Ampollini, Letizia Gnetti, Matteo Goldoni, Lorenzo Viani, Elisabetta Faedda, Nicoletta Campanini, Pietro Caruana, Pellegrino Crafa, Francesca Negri, Francesca Pucci, Francesco Leonardi, Luigi Ventura, Valeria Balestra, Cesare Braggio, Giovanni Bocchialini, Paolo Del Rio, Enrico Maria Silini, Paolo Carbognani, Michele Rusca
Background: Pulmonary metastasectomy is considered a standard procedure in the treatment of metastatic colorectal cancer (CRC). Different prognostic factors including multiple metastatic nodules, the presence of extra-pulmonary metastases and BRAF mutation status have been associated with poor survival. The aim of this study was to evaluate which factors influenced survival in CRC patients undergoing pulmonary metastasectomy by studying primary tumors and pulmonary metastases. Methods: All patients treated for primary CRC who presented pulmonary metastases in a 10-year period were considered (group A)...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29119012/prognostic-factors-after-pulmonary-metastasectomy-of-colorectal-cancers-a-single-center-experience
#12
Ludovic Fournel, Stefania Maria, Marie Seminel, Jessica Nesci, Audrey Mansuet-Lupo, Claude Guinet, Pierre Magdeleinat, Antonio Bobbio, Jean-François Regnard, Marco Alifano
Background: Surgical resection has been widely admitted as the treatment of choice for pulmonary metastases of colorectal cancer (CRC). Nevertheless, this practice is not supported by high level of evidence and patients' eligibility remains controversial. Aim of this study was to evaluate long terms results and factors influencing survival after lung metastasectomy of CRC. Methods: A single-center retrospective analysis of patients with pathologically proven colorectal metastasis, operated from 2004 to 2013, was performed...
October 2017: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29113730/conversion-to-resection-in-patients-receiving-systemic-chemotherapy-for-unresectable-and-or-metastatic-colorectal-cancer-predictive-factors-and-prognosis
#13
Hiroaki Nozawa, Soichiro Ishihara, Kazushige Kawai, Keisuke Hata, Tomomichi Kiyomatsu, Toshiaki Tanaka, Takeshi Nishikawa, Kensuke Otani, Koji Yasuda, Kazuhito Sasaki, Manabu Kaneko, Koji Murono
BACKGROUND: Systemic chemotherapy increases the possibility of resection in patients with initially unresectable colorectal cancer (CRC), especially patients with hepatic metastasis. However, the predictive factors and prognosis of conversion to resection after chemotherapy in patients with various organ metastases remain largely unknown. PATIENTS AND METHODS: We reviewed the data from metastatic CRC (mCRC) patients who had received oxaliplatin- or irinotecan-based systemic chemotherapy from 2005 to 2016...
October 19, 2017: Clinical Colorectal Cancer
https://www.readbyqxmd.com/read/29113675/surgery-induced-tumor-growth-in-metastatic-colorectal-cancer
#14
REVIEW
Klaas M Govaert, Jennifer M J Jongen, Onno Kranenburg, Inne H M Borel Rinkes
Metastatic colorectal cancer (mCRC) is a devastating disease causing 700.000 deaths annually worldwide. Metastases most frequently develop in the liver. Partial hepatectomy has dramatically improved clinical outcome and is the only curative treatment option for eligible patients with mCRC. Pre-clinical studies have shown that surgical procedures can have tumor-promoting local 'side-effects' such as hypoxia and inflammation, thereby altering the behaviour of residual tumor cells. In addition, systemically released factors following (colon or liver) surgery can act as a wakeup-call for dormant tumor cells in distant organs and/or help establish a pre-metastatic niche...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29113656/introduction-of-the-resection-severity-index-as-independent-risk-factor-limiting-survival-after-resection-of-colorectal-liver-metastases
#15
Jill Gwiasda, Harald Schrem, Alexander Kaltenborn, Jan Mahlmann, Heiko Mix, Frank Lehner, Nicolas Kayser, Jürgen Klempnauer, Ulf Kulik
BACKGROUND: The purpose of this study is to evaluate the influence of the recently introduced resection severity index (RSI) in patients with liver resection for hepatocellular carcinoma on survival after resection of colorectal liver metastases. The RSI quantifies pre-operatively the liver cellular damage, liver synthetic function and loss of organ parenchyma. METHODS: All consecutive patients who underwent liver resection for metastases of colorectal cancer (CLM) between 2000 and 2015 were included in this study...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29105339/prognostic-value-of-cd133-cd54-cd44-circulating-tumor-cells-in-colorectal-cancer-with-liver-metastasis
#16
Chao Fang, Chuanwen Fan, Cun Wang, Qiaorong Huang, Wentong Meng, Yongyang Yu, Lie Yang, Jiankun Hu, Yuan Li, Xianming Mo, Zongguang Zhou
In the previous study, we had showed the expression of CD133(+) CD54(+) CD44(+) cellular subpopulation of circulating tumor cells (CTCs) was significantly associated with liver metastasis of colorectal cancer (CRC). This study aimed to explore whether this subpopulation of CTCs have a prognostic value in CRC patients. Flow cytometry was used to detect the expression of cellular subpopulations of CTCs with CD133, CD54, and CD44 in 152 CRC patients, between December 2013 and October 2014. The impact of clinicopathological factors and the expression of cellular subpopulations of CTCs on overall survival were then analyzed...
November 3, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/29100436/meta-analysis-of-the-mutational-status-of-circulation-tumor-cells-and-paired-primary-tumor-tissues-from-colorectal-cancer-patients
#17
Yong Liu, Stefano Meucci, Liming Sheng, Ulrich Keilholz
As predictive markers for anti-EGFR therapy, KRAS and BRAF mutations are routinely detected in primary and metastatic colorectal cancer (CRC) cells, but seldom in circulating tumor cells (CTCs). Detecting mutations in CTCs could help explain mutational differences between tumor cells at local sites and distant metastases, thereby improving treatment outcomes. Here, we conducted a systematic review and meta-analysis to compare KRAS and BRAF mutations in paired CTCs and primary tumors from CRC patients, to detect any possible discordance...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100312/molecular-signatures-reflecting-microenvironmental-metabolism-and-chemotherapy-induced-immunogenic-cell-death-in-colorectal-liver-metastases
#18
Olga Østrup, Vegar Johansen Dagenborg, Einar Andreas Rødland, Veronica Skarpeteig, Laxmi Silwal-Pandit, Krzysztof Grzyb, Audun Elnæs Berstad, Åsmund Avdem Fretland, Gunhild Mari Mælandsmo, Anne-Lise Børresen-Dale, Anne Hansen Ree, Bjørn Edwin, Vigdis Nygaard, Kjersti Flatmark
Background: Metastatic colorectal cancer (CRC) is associated with highly variable clinical outcome and response to therapy. The recently identified consensus molecular subtypes (CMS1-4) have prognostic and therapeutic implications in primary CRC, but whether these subtypes are valid for metastatic disease is unclear. We performed multi-level analyses of resectable CRC liver metastases (CLM) to identify molecular characteristics of metastatic disease and evaluate the clinical relevance...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29100290/cd133-targeted-oncolytic-adenovirus-demonstrates-anti-tumor-effect-in-colorectal-cancer
#19
Mizuho Sato-Dahlman, Yoshiaki Miura, Jing Li Huang, Praveensingh Hajeri, Kari Jacobsen, Julia Davydova, Masato Yamamoto
Oncolytic Adenoviruses (OAds) are one of the most promising anti-cancer agents that can induce cancer specific cell death. Recently, we generated infectivity-selective OAd, and the resultant OAd tumor-specific binding shows strong efficacy and mitigates toxicity. In this study, we applied this strategy based on adenovirus library screening system for generation of CD133-targeted OAd, and examined their oncolytic activity against colorectal cancer (CRC) in vitro and in vivo. CD133 (Prominin-1) is an important cell surface marker of cancer stem (like) cells (CSCs) in various cancers, including CRC...
September 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29098384/prognostic-influence-of-hepatic-margin-after-resection-of-colorectal-liver-metastasis-role-of-modern-preoperative-chemotherapy
#20
Frank Makowiec, Peter Bronsert, Andrea Klock, Ulrich T Hopt, Hannes P Neeff
PURPOSE: Modern chemotherapy (CTX) increases survival in stage IV colorectal cancer. In colorectal liver metastases (CLM), neoadjuvant (neo) CTX may increase resectability and improve survival. Due to widespread use of CTX in CLM, recent studies assessed the role of the hepatic margin after CTX, with conflicting results. We evaluated the outcome after resection of CLM in relation to CTX and hepatic resection status. METHODS: Since 2000, 334 patients with first hepatic resection for isolated CLM were analyzed...
November 2, 2017: International Journal of Colorectal Disease
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