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https://www.readbyqxmd.com/read/29053654/retrospective-analysis-of-jaw-biopsies-in-young-adults-a-study-of-1599-cases-in-southern-brazil
#1
K Silva, A Alves, M Correa, A Etges, A-C Vasconcelos, A-P Gomes, S Tarquinio
BACKGROUND: To evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis. MATERIAL AND METHODS: In this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected...
October 20, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29052442/denosumab-for-the-treatment-of-bone-disease-in-solid-tumors-and-multiple-myeloma
#2
Andrew J Yee, Noopur S Raje
Bone is a common site for malignant involvement, either as a site of metastasis, especially in breast or prostate cancer, or as a defining characteristic of the disease, as in multiple myeloma. Bone disease is a major source of morbidity, and half of patients with bone involvement develop skeletal-related events such as pathological fractures or cord compression requiring surgery and/or radiation. Skeletal involvement also increases mortality, as pathologic fractures increase the risk of dying by 20-40%. Osteoclast inhibition with bisphosphonates such as zoledronic acid and recently denosumab has been a significant improvement for bone disease...
October 20, 2017: Future Oncology
https://www.readbyqxmd.com/read/29051537/microarray-gene-expression-of-periosteum-in-spontaneous-bone-regeneration-of-mandibular-segmental-defects
#3
Zheyi Li, Juli Pan, Jinling Ma, Zhen Zhang, Yuxing Bai
Spontaneous bone regeneration could occur to reestablish mandibular bony continuity in patients who underwent partial or total mandibulectomy for tumors with periosteum-preserving. However, scarce data is available related to the precise role of periosteum in this bone regeneration. Therefore we aimed to investigate the gene expression of periosteum that were involved in the mandibular bone regeneration. Mandibular segmental defects were created in six mini-pigs with periosteum preserved. The periosteum of defects and control site were harvested at 1 and 2 weeks...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051534/surface-marker-profiling-of-sh-sy5y-cells-enables-small-molecule-screens-identifying-bmp4-as-a-modulator-of-neuroblastoma-differentiation
#4
Fraua Christina Ferlemann, Vishal Menon, Alexandra Larisa Condurat, Jochen Rößler, Jan Pruszak
Neuroblastoma is the most common extra-cranial solid tumor in children. Its broad spectrum of clinical outcomes reflects the underlying inherent cellular heterogeneity. As current treatments often do not lead to tumor eradication, there is a need to better define therapy-resistant neuroblastoma and to identify new modulatory molecules. To this end, we performed the first comprehensive flow cytometric characterization of surface molecule expression in neuroblastoma cell lines. Exploiting an established clustering algorithm (SPADE) for unbiased visualization of cellular subsets, we conducted a multiwell screen for small molecule modulators of neuroblastoma phenotype...
October 19, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29051281/cancer-in-the-national-cancer-institute-inherited-bone-marrow-failure-syndrome-cohort-after-15-years-of-follow-up
#5
Blanche P Alter, Neelam Giri, Sharon A Savage, Philip S Rosenberg
The National Cancer Institute Inherited Bone Marrow Failure Syndromes Cohort enrolls patients with the four major syndromes: Fanconi anemia, dyskeratosis congenita, Diamond Blackfan anemia, and Shwachman Diamond syndrome, and follows them with a common comprehensive protocol. The current analysis includes more than double the numbers of patients and person-years since our first report in 2010. Patients with Fanconi anemia and dyskeratosis congenita developed head and neck and anogenital squamous cell carcinomas at rates that are hundreds-fold greater than the general population...
October 19, 2017: Haematologica
https://www.readbyqxmd.com/read/29051115/an-herbal-formula-consisting-of-schisandra-chinensis-turcz-baill-lycium-chinense-mill-and-eucommia-ulmoides-oliv-alleviates-disuse-muscle-atrophy-in-rats
#6
Seongguk Cho, Riwon Hong, Poorm Yim, Mijung Yeom, Bombi Lee, Woong Mo Yang, Jongki Hong, Hyang Sook Lee, Dae-Hyun Hahm
ETHNOPHARMACOLOGICAL RELEVANCE: Schisandra chinensis (Turcz.) Baill (SC), Lycium chinense Mill (LC) and Eucommia ulmoides Oliv (EU) are representative tonic herbal medicines that help to strengthen body muscles and bones making them stronger according to the Donguibogam, a tradition medical book of the Joseon Dynasty in Korea. AIM OF STUDY: To evaluate effects of an herbal formula consisting of SC, LC and EU on muscle atrophy in C2C12 myotubes and in a rat model of immobilization-induced muscle atrophy...
October 16, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29050494/whole-transcriptome-analysis-identifies-differentially-regulated-networks-between-osteosarcoma-and-normal-bone-samples
#7
Xuan Dung Ho, Phuong Phung, Van Q Le, Van H Nguyen, Ene Reimann, Ele Prans, Gea Kõks, Katre Maasalu, Nghi Tn Le, Le H Trinh, Hoang G Nguyen, Aare Märtson, Sulev Kõks
We performed whole transcriptome analysis of osteosarcoma bone samples. Initially, we sequenced total RNA from 36 fresh-frozen samples (18 tumoral bone samples and 18 non-tumoral paired samples) matching in pairs for each osteosarcoma patient. We also performed independent gene expression analysis of formalin-fixed paraffin-embedded samples to verify the RNAseq results. Formalin-fixed paraffin-embedded samples allowed us to analyze the effect of chemotherapy. Data were analyzed with DESeq2, edgeR and Reactome packages of R...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29050355/dual-time-point-18-f-fdg-pet-ct-imaging-with-multiple-metabolic-parameters-in-the-differential-diagnosis-of-malignancy-suspected-bone-joint-lesions
#8
Chen-Tian Shen, Zhong-Ling Qiu, Zhen-Kui Sun, Wei-Jun Wei, Hong-Jun Song, Xin-Yun Zhang, Quan-Yong Luo
The purpose of this study was to evaluate the diagnostic potential of dual time-point(18)F-FDG PET/CT imaging with multiple metabolic parameters in malignancy-suspected bone/joint lesions. Fifty seven consecutive patients were recruited. PET parameters including SUVmax, SUVmean, metabolic tumor volume (MTV), total lesional glycolysis (TLG) and retention indexes (RIs) were obtained. Thirty five malignant and 22 benign lesions were confirmed by pathology. In all, 48 receiver operating characteristic (ROC) curves were derived...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050203/loss-of-egr1-a-human-del5q-gene-accelerates-bcr-abl-driven-chronic-myelogenous-leukemia
#9
Silvia Maifrede, Andrew Magimaidas, Xiaojin Sha, Kaushiki Mukherjee, Dan A Liebermann, Barbara Hoffman
There is substantial evidence that early growth response-1 (Egr1) gene, a zinc-finger transcription factor, behaves as a tumor suppressor in leukemia. This includes reports from this laboratory that constitutive Egr1 overrides leukemia conferred by deregulated c-Myc or E2F-1 in the M1 myeloid leukemic cell line by promoting differentiation. To investigate the effect of Egr1 on the initiation and progression of Chronic Myelogenous Leukemia (CML), lethally irradiated syngeneic wild type mice were reconstituted with bone marrow (BM) from either wild type or Egr1 null mice transduced with a 210-kD BCR-ABL-expressing MSCV-retrovirus (bone marrow transplantation {BMT})...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050201/htlv-1-viral-oncogene-hbz-induces-osteolytic-bone-disease-in-transgenic-mice
#10
Alison K Esser, Daniel A Rauch, Jingyu Xiang, John C Harding, Nicole A Kohart, Michael H Ross, Xinming Su, Kevin Wu, Devra Huey, Yalin Xu, Kiran Vij, Patrick L Green, Thomas J Rosol, Stefan Niewiesk, Lee Ratner, Katherine N Weilbaecher
Adult T-cell leukemia/lymphoma (ATL) is an aggressive T cell malignancy that occurs in HTLV-1 infected patients. Most ATL patients develop osteolytic lesions and hypercalcemia of malignancy, causing severe skeletal related complications and reduced overall survival. The HTLV-1 virus encodes 2 viral oncogenes, Tax and HBZ. Tax, a transcriptional activator, is critical to ATL development, and has been implicated in pathologic osteolysis. HBZ, HTLV-1 basic leucine zipper transcription factor, promotes tumor cell proliferation and disrupts Wnt pathway modulators; however, its role in ATL induced osteolytic bone loss is unknown...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050112/-clinical-pathologic-characteristics-and-treatment-outcomes-of-19-relapsed-pediatric-b-cell-lymphoma
#11
S Huang, L Jin, J Yang, Y L Duan, M Zhang, C J Zhou, X L Ma, Y H Zhang
Objective: To review the clinical-pathology characteristics of 19 relapsed pediatric mature B cell lymphoma and to find the risk factors for recurrence and the feasible treatment after relapse. Method: Data of 212 pediatric B cell lymphomas cases in Beijing Children's Hospital from January 2006 to June 2015 were collected retrospectively. All the patients were treated according to the B cell lymphoma regimen of Beijing Children's Hospital. During the study period, 19 of 212 cases were relapsed; the clinio-pathological characteristics of relapsed patients before treatment and after relapse were analyzed retrospectively, the treatment outcomes after relapse were summarized and the patients were followed-up...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29050111/-a-long-term-follow-up-report-of-pediatric-relapsed-wilms-tumor-after-retreatment
#12
T Y Wang, C Pan, Y J Gao, W T Hu, Q D Ye, M Zhou, J Y Tang
Objective: To investigate the long-term efficacy and prognostic factors of pediatric relapsed Wilms tumor (WT) after retreatment. Method: Sixteen children in Shanghai Children's Medical Center with relapsed Wilms tumor were enrolled consecutively in this study between April 2006 and June 2016. All patients were diagnosed according to pathology, imaging and medical and surgical oncologist's assistance. Relapse treatment included surgical excision, chemotherapy and selective radiation therapy. The clinical features, long-term outcomes and prognostic factors of patients were analyzed retrospectively...
October 2, 2017: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/29050071/-poorly-differentiated-chordoma-with-ini1-loss-a-clinicopathologic-study
#13
J Y Feng, L Chen, Y Y Ma, H W Yang, L Chen
Objective: To analyze the clinicopathologic characteristics of poorly-differentiated chordoma with INI1 loss in children and to discuss the differential diagnosis. Methods: The clinical, radiological, histopathological profiles and molecular pathologic characteristics of two pediatric poorly differentiated chordoma cases with INI1 loss were reviewed. Results: The patients were a girl and a boy. Both lesions involved the slope. Both patients were presented with progressive muscle weakness or neck pain. Radiological examination showed clivus bone destruction and compression of the brain stem and cervical spinal cord...
October 8, 2017: Zhonghua Bing Li Xue za Zhi Chinese Journal of Pathology
https://www.readbyqxmd.com/read/29049899/intraosseous-hemangioma-of-the-frontal-bone-report-of-a-case-and-review-of-the-literature
#14
Joshua S Brandner, Yeshwant B Rawal, Louis J Kim, Jasjit K Dillon
Intraosseous hemangiomas of the maxillofacial region are rare lesions that constitute less than 1% of all osseous tumors. A review of the literature on intraosseous hemangiomas of the skull and facial bones showed a limited number of publications, much of which were largely limited to case reports. This case report summarizes the workup and surgical treatment of a 39-year-old woman with an intraosseous hemangioma of the left frontal bone. The histology, treatment, and literature are reviewed.
September 23, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29049187/a-myeloid-sarcoma-involving-the-small-intestine-kidneys-mesentery-and-mesenteric-lymph-nodes-a-case-report-and-literature-review
#15
Ping Wang, Quan Li, Li Zhang, Hong Ji, Cheng-Zhou Zhang, Bin Wang
RATIONALE: Myeloid sarcomas (MSs) are rare malignant hematological tumors. They most commonly occur in patients with acute or chronic myeloid leukemia. A de novo MS with no evidence of blood system disease is rare, but may represent the first sign of a systemic illness that precedes a full-blown disease. Herein, we report the computed tomography (CT) findings of an extremely rare case of a nonleukemic MS that progressed to acute myelogenous leukemia (AML) and simultaneously involved the small intestine, kidneys, mesentery, and mesenteric lymph nodes...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29048579/development-of-high-grade-osteosarcoma-in-a-patient-with-recurrent-giant-cell-tumor-of-the-ischium-while-receiving-treatment-with-denosumab
#16
Shinji Tsukamoto, Alberto Righi, Daniel Vanel, Kanya Honoki, Davide Maria Donati, Costantino Errani
Malignant transformation of giant cell tumor of bone (GCTB) without radiotherapy exposure is exceptionally rare, occurring in less than 1% of GCTBs. The safety and efficacy of denosumab in patients with GCTB was recently reported. We herein report a case of a benign recurrent GCTB with an H3F3A mutation that underwent secondary malignant transformation during treatment with denosumab. A 29-year-old woman underwent curettage of a GCTB of the left ischium in 2005. Ten years after the first surgery, the GCTB recurred locally...
November 1, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29048237/lenvatinib-for-the-treatment-of-radio-iodine-refractory-thyroid-cancer-in-real-life-practice
#17
Amandine Berdelou, Isabelle Borget, Yann Godbert, Thierry Nguyen, Marie-Eve Garcia, Cecile N Chougnet, Aurélie Ferru, Camille Buffet, Olivier Chabre, Olivier Huillard, Sophie Leboulleux, Martin Schlumberger
BACKGROUND: In the SELECT phase III trial in advanced radio-iodine refractory differentiated thyroid cancer (rDTC), lenvatinib improved median progression free survival (PFS) over placebo by almost 15 months and induces an objective response rate of 64.8%, but adverse events occurred in almost all patients. The present study evaluates the efficacy and toxicity of lenvatinib treatment in real-life practice. METHODS: Clinical charts of 88 consecutive patients treated with lenvatinib from July 2015 to June 2016 in 27 French centers were retrospectively reviewed...
October 19, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/29047366/the-use-of-cinacalcet-hinders-the-diagnosis-of-parathyroid-carcinoma-in-a-chronic-dialysis-patient-a-case-report
#18
Daisuke Takada, Tatsuo Tsukamoto, Miho Fuse, Shinpei Kada, Motoko Yanagita
BACKGROUND: Secondary hyperparathyroidism (SHPT) is a common complication in patients receiving chronic dialysis therapy. Although cinacalcet can control parathyroid function and bone turnover, preventing ectopic calcification remains challenging. Cinacalcet can also suppress PTH secretion due to parathyroid carcinoma in the same way as it does for parathyroid hyperplasia in the uremic condition. We present a case of parathyroid carcinoma partially controlled by cinacalcet, in which tumorous calcinosis was successfully resolved by total parathyroidectomy...
October 18, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/29047262/current-understanding-of-rank-signaling-in-osteoclast-differentiation-and-maturation
#19
Jin Hee Park, Na Kyung Lee, Soo Young Lee
Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL) for their survival, proliferation, differentiation, and activation. The binding of RANKL to its receptor RANK triggers osteoclast precursors to differentiate into osteoclasts. This process depends on RANKL-RANK signaling, which is temporally regulated by various adaptor proteins and kinases. Here we summarize the current understanding of the mechanisms that regulate RANK signaling during osteoclastogenesis...
October 17, 2017: Molecules and Cells
https://www.readbyqxmd.com/read/29046788/a-rare-case-of-dedifferentiated-liposarcoma-of-the-sinonasal-cavity-a-case-report
#20
Masaru Miyazaki, Mikiko Aoki, Satoru Oba, Toshifumi Sakata, Takashi Nakagawa, Kazuki Nabeshima
Sarcoma is an uncommon histopathological presentation of sinonasal tumors, comprising ~15% of all cases; liposarcoma is particularly uncommon. An analysis of the available medical literature revealed no prior reports of dedifferentiated liposarcoma (DDLPS) of the sinonasal cavity. This case report presents a rare case of DDLPS of the sinonasal cavity. A 40-year old six-week pregnant female was admitted with a left nasal obstruction. Endoscopic evaluation of the left nasal cavity revealed a polypoid lesion. A computed tomography scan indicated a mass invading the left nasal cavity, maxillary sinus and anterior ethmoid sinus with focal destruction of the surrounding bone...
October 2017: Molecular and Clinical Oncology
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