Luke E Schepers, Brooke L Martindale, Alycia G Berman, Hannah L Cebull, William Van Alstine, Sydney E Hollingshead, Tyler Novak, Craig J Goergen
Hemorrhage is the second leading cause of death in patients under 46 years of age in the United States. Cessation of hemorrhage prevents hemorrhagic shock and tissue hypoxia. Controlling the bleed via direct pressure or tourniquet is often the first line of defense, but long-term care requires staples, hemostatic agents, or sealants that seal the vessel and restore blood flow. Here, we compare a new photocurable extracellular matrix sealant (pcECM) with low, medium, and high crosslink density formulations to a commercially available fibrin-based sealant, TISSEEL®...
April 2024: Journal of Biomedical Materials Research. Part B, Applied Biomaterials