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https://www.readbyqxmd.com/read/29660164/high-grade-panin-presenting-with-localized-stricture-of-the-main-pancreatic-duct-a-clinicopathological-and-molecular-study-of-10-cases-suggests-a-clue-for-the-early-detection-of-pancreatic-cancer
#1
Masataka Yokode, Masayuki Akita, Kohei Fujikura, Mi-Ju Kim, Yukiko Morinaga, Seiichi Yoshikawa, Takuro Terada, Hiroshi Matsukiyo, Takuma Tajiri, Shiho Abe-Suzuki, Tomoo Itoh, Seung-Mo Hong, Yoh Zen
AIMS: This study aimed to identify the pathological features of high-grade PanIN that presents with imaging-detectable abnormalities. METHODS AND RESULTS: Ten cases of isolated, main-duct, high-grade PanIN as the primary clinical presentation were identified. All patients presented with stenosis of the main pancreatic duct, with 2 being associated with extensive upstream duct dilatation (>5 mm in diameter). Pancreatic juice cytology suggested adenocarcinoma in all 7 cases examined...
April 16, 2018: Histopathology
https://www.readbyqxmd.com/read/29658052/reduced-%C3%AE-glcnac-glycosylation-on-gastric-gland-mucin-is-a-biomarker-of-malignant-potential-for-gastric-cancer-barrett-s-adenocarcinoma-and-pancreatic-cancer
#2
REVIEW
Kazuhiro Yamanoi, Jun Nakayama
Gastric gland mucin secreted from pyloric gland cells, mucous neck cells, and cardiac gland cells of the gastric mucosa harbors unique O-glycans carrying terminal α1,4-linked N-acetylglucosamine residues (αGlcNAc), which are primarily attached to the scaffold mucin core protein MUC6. αGlcNAc acts as an antibiotic against Helicobacter pylori (H. pylori), a microbe causing gastric cancer. In addition, mice deficient in A4gnt, which encodes the enzyme α1,4-N-acetylglucosaminyltransferase (α4GnT) that catalyzes αGlcNAc biosynthesis, spontaneously develop gastric differentiated-type adenocarcinoma, even if not infected by H...
April 16, 2018: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/29651002/metformin-decreases-the-incidence-of-pancreatic-ductal-adenocarcinoma-promoted-by-diet-induced-obesity-in-the-conditional-krasg12d-mouse-model
#3
Hui-Hua Chang, Aune Moro, Caroline Ei Ne Chou, David W Dawson, Samuel French, Andrea I Schmidt, James Sinnett-Smith, Fang Hao, O Joe Hines, Guido Eibl, Enrique Rozengurt
Pancreatic ductal adenocarcinoma (PDAC) is a particularly deadly disease. Chronic conditions, including obesity and type-2 diabetes are risk factors, thus making PDAC amenable to preventive strategies. We aimed to characterize the chemo-preventive effects of metformin, a widely used anti-diabetic drug, on PDAC development using the KrasG12D mouse model subjected to a diet high in fats and calories (HFCD). LSL-KrasG12D/+ ;p48-Cre (KC) mice were given control diet (CD), HFCD, or HFCD with 5 mg/ml metformin in drinking water for 3 or 9 months...
April 12, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29621546/aberrant-upregulation-of-klk10-promotes-metastasis-via-enhancement-of-emt-and-fak-src-erk-axis-in-pdac
#4
Xiao-Yan Cao, Xiao-Xin Zhang, Min-Wei Yang, Li-Peng Hu, Shu-Heng Jiang, Guang-Ang Tian, Li-Li Zhu, Qing Li, Yong-Wei Sun, Zhi-Gang Zhang
Pancreatic Ductal Adenocarcinoma (PADC) metastasis is the leading cause of morality of this severe malignant tumor. Proteases are key players in the degradation of extracellular matrix which promotes the cascade of tumor metastasis. As a kind of serine proteases, the kallikrein family performs vital function on the cancer proteolysis scene, which have been proved in diverse malignant tumors. However, the specific member of kallikrein family and its function in PDAC remain unexplored. In this study, by data mining of GEO datasets, we have identified KLK10 is upregulated gene in PDAC...
April 2, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29604293/immune-cell-production-of-interleukin-17-induces-stem-cell-features-of-pancreatic-intraepithelial-neoplasia-cells
#5
Yu Zhang, Michelle Zoltan, Erick Riquelme, Hanwen Xu, Ismet Sahin, Susana Castro-Pando, Maria Fernanda Montiel, Kyle Chang, Zhengyu Jiang, Jianhua Ling, Sonal Gupta, William Horne, Melissa Pruski, Huamin Wang, Shao-Cong Sun, Guillermina Lozano, Paul Chiao, Anirban Maitra, Steven D Leach, Jay K Kolls, Eduardo Vilar Sanchez, Timothy C Wang, Jennifer M Bailey, Florencia McAllister
BACKGROUND & AIMS: Little is known about how the immune system affects stem cell features of pancreatic cancer cells. Immune cells that produce interleukin 17 A (IL17A) in the chronically inflamed pancreas (chronic pancreatitis) contribute to PanIN initiation and progression. We investigated the effects of IL17A signaling exerts on pancreatic cancer progenitor cells and the clinical relevance of this phenomena. METHODS: We performed studies with Mist1Cre;LSLKras;Rosa26mTmG (KCiMist ;G) and Kras(G12D); Trp53(R172H); Pdx1-Cre (KPC) mice (which upon tamoxifen induction spontaneously develop pancreatic intraepithelial neoplasias, PanINs) and control littermates...
March 28, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29604291/arid1a-maintains-differentiation-of-pancreatic-ductal-cells-and-inhibits-development-of-pancreatic-ductal-adenocarcinoma-in-mice
#6
Yoshito Kimura, Akihisa Fukuda, Satoshi Ogawa, Takahisa Maruno, Yutaka Takada, Motoyuki Tsuda, Yukiko Hiramatsu, Osamu Araki, Munemasa Nagao, Takaaki Yoshikawa, Kozo Ikuta, Takuto Yoshioka, Zong Wang, Haruhiko Akiyama, Christopher V Wright, Kyoichi Takaori, Shinji Uemoto, Tsutomu Chiba, Hiroshi Seno
BACKGROUND & AIMS: The AT-rich interaction domain 1A gene (ARID1A) encodes a protein that is part of the large ATP-dependent chromatin remodeling complex SWI/SNF and is frequently mutated in human pancreatic ductal adenocarcinomas (PDACs). We investigated the functions of ARID1A during formation of PDACs in mice. METHODS: We performed studies with Ptf1a-Cre; KrasG12D mice, which express activated Kras in the pancreas and develop pancreatic intraepithelial neoplasias (PanINs), as well as those with disruption of Aird1a (Ptf1a-Cre; KrasG12D ; Arid1af/f mice) or disruption of Brg1 (encodes a catalytic ATPase of the SWI/SNF complex) (Ptf1a-Cre; KrasG12D ; Brg1f/f mice)...
March 28, 2018: Gastroenterology
https://www.readbyqxmd.com/read/29596465/homozygous-ksr1-deletion-attenuates-morbidity-but-does-not-prevent-tumor-development-in-a-mouse-model-of-ras-driven-pancreatic-cancer
#7
Elizabeth A Germino, Joseph P Miller, Lauri Diehl, Carter J Swanson, Steffen Durinck, Zora Modrusan, Jeffrey H Miner, Andrey S Shaw
Given the frequency with which MAP kinase signaling is dysregulated in cancer, much effort has been focused on inhibiting RAS signaling for therapeutic benefit. KSR1, a pseudokinase that interacts with RAF, is a potential target; it was originally cloned in screens for suppressors of constitutively active RAS, and its deletion prevents RAS-mediated transformation of mouse embryonic fibroblasts. In this work, we used a genetically engineered mouse model of pancreatic cancer to assess whether KSR1 deletion would influence tumor development in the setting of oncogenic RAS...
2018: PloS One
https://www.readbyqxmd.com/read/29533466/the-advanced-glycation-endproduct-n-%C3%AE%C2%B5-carboxymethyllysine-promotes-progression-of-pancreatic-cancer-implications-for-diabetes-associated-risk-and-its-prevention
#8
Stefano Menini, Carla Iacobini, Luisa de Latouliere, Isabella Manni, Vittoria Ionta, Claudia Blasetti Fantauzzi, Carlo Pesce, Paola Cappello, Francesco Novelli, Giulia Piaggio, Giuseppe Pugliese
Diabetes is an established risk factor for pancreatic cancer (PaC), together with obesity, Western diet and tobacco smoking. The common mechanistic link might be the accumulation of advanced glycation endproducts (AGEs), which characterizes all the above disease conditions and unhealthy habits. Surprisingly, however, the role of AGEs in PaC has not been examined yet, despite the evidence of a tumor-promoting role of RAGE, the receptor for AGEs. Here, we tested the hypothesis that AGEs promote PaC through RAGE activation...
March 13, 2018: Journal of Pathology
https://www.readbyqxmd.com/read/29527444/the-effect-of-atmospheric-doping-on-pressure-dependent-raman-scattering-in-supported-graphene
#9
Egor A Kolesov, Mikhail S Tivanov, Olga V Korolik, Olesya O Kapitanova, Xiao Fu, Hak Dong Cho, Tae Won Kang, Gennady N Panin
Atmospheric doping of supported graphene was investigated by Raman scattering under different pressures. Various Raman spectra parameters were found to depend on the pressure and the substrate material. The results are interpreted in terms of atmospheric adsorption leading to a change in graphene charge carrier density and the effect of the substrate on the electronic and phonon properties of graphene. It was found that adsorption of molecules from the atmosphere onto graphene doped with nitrogen (electron doping) compensates for the electron charge...
2018: Beilstein Journal of Nanotechnology
https://www.readbyqxmd.com/read/29526803/pancreatic-dclk1-cells-originate-distinctly-from-pdx1-progenitors-and-contribute-to-the-initiation-of-intraductal-papillary-mucinous-neoplasm-in-mice
#10
Wanglong Qiu, Helen E Remotti, Sophia M Tang, Elizabeth Wang, Lily Dobberteen, Ayman Lee Youssof, Joo Hee Lee, Edwin C Cheung, Gloria H Su
PanINs and IPMNs are the two most common precursor lesions that can progress to invasive pancreatic ductal adenocarcinoma (PDA). DCLK1 has been identified as a biomarker of progenitor cells in PDA progressed from PanINs. To explore the potential role of DCLK1-expressing cells in the genesis of IPMNs, we compared the incidence of DCLK1-positive cells in pancreatic tissue samples from genetically-engineered mouse models (GEMMs) for IPMNs, PanINs, and acinar to ductal metaplasia by immunohistochemistry and immunofluorescence...
March 8, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29481189/quasifree-p-2p-reactions-on-oxygen-isotopes-observation-of-isospin-independence-of-the-reduced-single-particle-strength
#11
L Atar, S Paschalis, C Barbieri, C A Bertulani, P Díaz Fernández, M Holl, M A Najafi, V Panin, H Alvarez-Pol, T Aumann, V Avdeichikov, S Beceiro-Novo, D Bemmerer, J Benlliure, J M Boillos, K Boretzky, M J G Borge, M Caamaño, C Caesar, E Casarejos, W Catford, J Cederkall, M Chartier, L Chulkov, D Cortina-Gil, E Cravo, R Crespo, I Dillmann, Z Elekes, J Enders, O Ershova, A Estrade, F Farinon, L M Fraile, M Freer, D Galaviz Redondo, H Geissel, R Gernhäuser, P Golubev, K Göbel, J Hagdahl, T Heftrich, M Heil, M Heine, A Heinz, A Henriques, A Hufnagel, A Ignatov, H T Johansson, B Jonson, J Kahlbow, N Kalantar-Nayestanaki, R Kanungo, A Kelic-Heil, A Knyazev, T Kröll, N Kurz, M Labiche, C Langer, T Le Bleis, R Lemmon, S Lindberg, J Machado, J Marganiec-Gałązka, A Movsesyan, E Nacher, E Y Nikolskii, T Nilsson, C Nociforo, A Perea, M Petri, S Pietri, R Plag, R Reifarth, G Ribeiro, C Rigollet, D M Rossi, M Röder, D Savran, H Scheit, H Simon, O Sorlin, I Syndikus, J T Taylor, O Tengblad, R Thies, Y Togano, M Vandebrouck, P Velho, V Volkov, A Wagner, F Wamers, H Weick, C Wheldon, G L Wilson, J S Winfield, P Woods, D Yakorev, M Zhukov, A Zilges, K Zuber
Quasifree one-proton knockout reactions have been employed in inverse kinematics for a systematic study of the structure of stable and exotic oxygen isotopes at the R^{3}B/LAND setup with incident beam energies in the range of 300-450  MeV/u. The oxygen isotopic chain offers a large variation of separation energies that allows for a quantitative understanding of single-particle strength with changing isospin asymmetry. Quasifree knockout reactions provide a complementary approach to intermediate-energy one-nucleon removal reactions...
February 2, 2018: Physical Review Letters
https://www.readbyqxmd.com/read/29462213/early-detection-of-pancreatic-cancer-in-mouse-models-using-a-novel-antibody-tab004
#12
Shu-Ta Wu, Chandra D Williams, Priyanka A Grover, Laura J Moore, Pinku Mukherjee
Pancreatic ductal adenocarcinoma (PDA) is the fourth-leading cause of cancer death in the United States with a 5-year overall survival rate of 8% for all stages combined. But this decreases to 3% for the majority of patients that present with stage IV PDA at time of diagnosis. The lack of distinct early symptoms for PDA is one of the primary reasons for the late diagnosis. Common symptoms like weight loss, abdominal and back pains, and jaundice are often mistaken for symptoms of other issues and do not appear until the cancer has progressed to a late stage...
2018: PloS One
https://www.readbyqxmd.com/read/29442787/influence-of-the-quantum-well-structure-and-growth-temperature-on-a-five-layer-ingamnas-quantum-well-with-an-ingaas-buffer-layer
#13
Im Taek Yoon, Sejoon Lee, Dmitry V Roshchupkin, Gennady N Panin
The influence of quantum well structure and growth temperature on a synthesized multilayer system composed of a five-layer InMnGaAs quantum well with an InGaAs buffer layer grown on semi-insulating (100)-oriented substrates prepared by low temperature molecular beam epitaxy was studied. The magnetization measurements using a superconducting quantum interference device indicated the existence of ferromagnetism with a Curie temperature above room temperature in the five-layer InGaMnAs quantum well structure with an InGaAs buffer layer in a GaAs matrix...
June 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29439015/respiratory-motion-compensation-for-pet-ct-with-motion-information-derived-from-matched-attenuation-corrected-gated-pet-data
#14
Yihuan Lu, Kathryn Fontaine, Tim Mulnix, John A Onofrey, Silin Ren, Vladimir Panin, Judson Jones, Michael E Casey, Robert Barnett, Peter Kench, Roger Fulton, Richard E Carson, Chi Liu
Respiratory motion degrades the detection and quantification capabilities of PET/CT imaging. Moreover, mismatch between a fast helical CT and a time-averaged PET image due to respiratory motion results in additional attenuation correction (AC) artifacts and inaccurate localization. Current motion compensation (MC) approaches typically have three limitations: 1) the mismatch among respiratory-gated PET images and the CTAC map can introduce artifacts in the gated PET reconstructions that can subsequently affect the accuracy of the motion estimation; 2) sinogram-based correction approaches do not correct for intra-gate motion due to intra-cycle and inter-cycle breathing variations; 3) the mismatch between the PET MC-reference gate and CT can cause additional CT-mismatch artifact...
February 9, 2018: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/29433879/expression-of-neuropeptide-y-and-its-receptors-y1-and-y2-in-pancreatic-intraepithelial-neoplasia-and-invasive-pancreatic-cancer-in-a-transgenic-mouse-model-and-human-samples-of-pancreatic-cancer
#15
Jens Waldmann, Volker Fendrich, Martin Reichert, Andreas Hecker, Detlef K Bartsch, Winfried Padberg, Julia P N Holler
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is among the most dismal of human malignancies. Neuropeptides have shown to be implicated in angiogenesis, tumor growth, and formation of distant metastases in various solid tumors. In the present study, we used a genetically engineered mouse model of pancreatic cancer to evaluate the impact of neuropeptide Y (NPY) and its receptors 1 (Y1) and 2 (Y2) in preneoplastic lesions and pancreatic cancer as a potential target with antiproliferative properties...
March 2018: Journal of Surgical Research
https://www.readbyqxmd.com/read/29388054/p16-p21-and-p53-proteins-play-an-important-role-in-development-of-pancreatic-intraepithelial-neoplastic
#16
Justyna Zińczuk, Konrad Zaręba, Katarzyna Guzińska-Ustymowicz, Bogusław Kędra, Andrzej Kemona, Anna Pryczynicz
BACKGROUND: Deregulation of cell cycle takes place during the development of many cancers as well as pancreatic ductal adenocarcinoma (PDA), which develops from precursor lesions, most frequently including pancreatic intraepithelial neoplasia (PanIN). AIMS: The aim of this study was to evaluate and compare the expression of p16, p21, and p53 proteins taking part in the regulation of the cell cycle in normal pancreatic ducts and pancreatic intraepithelial neoplasia at its various advancing stages...
February 1, 2018: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/29376951/-perforated-cholecystitis-classification-and-atypical-clinical-forms
#17
A G Beburishvili, S I Panin, E N Zyubina
AIM: To obtain new data for diagnosis and treatment of patients with perforated cholecystitis. MATERIAL AND METHODS: It was analyzed the variants of original classification of perforated cholecystitis by Fedorov S.P. - Neimeier O.W. (1934). Moreover, we have assessed treatment of 292 patients with gallbladder perforation (own material of Faculty Surgery Clinic). RESULTS: According to continuous 20-year follow-up perforated cholecystitis was observed in 2...
2018: Khirurgiia
https://www.readbyqxmd.com/read/29367759/genetic-and-pharmacologic-abrogation-of-snail1-inhibits-acinar-to-ductal-metaplasia-in-precursor-lesions-of-pancreatic-ductal-adenocarcinoma-and-pancreatic-injury
#18
Volker Fendrich, Frederike Jendryschek, Saskia Beeck, Max Albers, Matthias Lauth, Farzad Esni, Kristin Heeger, Janina Dengler, Emily P Slater, Julia P N Holler, Aninja Baier, Detlef K Bartsch, Jens Waldmann
Pancreatic cancer (PDAC) is one of the most dismal of human malignancies. Inhibiting or delaying the progression of precursor lesions of PDAC, pancreatic intraepthial neoplasia (PanINs), to invasive cancer, would be a major step. In the present study, we used a transgenic murine model of pancreatic cancer to evaluate the impact of a conditional knockout of the transcription factor Snail1, a major factor in epithelial-to-mesenchymal transition, on acinar-to-ductal formation and on PanIN progression. By interbreeding conditional LsL-Snailfloxf/wt ; LsL-KrasG12D and Pdx1-Cre strains, we obtained LsL-KrasG12D ;Pdx1-Cre(KP) mice, Snail1 heterozygous knockout LsL-KrasG12D ; LsL-Snailflox/- ;Pdx1-Cre(KPShet ) mice or Snail1 homozygous knockout LsL-KrasG12D ;LsL-Snailflox/flox ;Pdx1-Cre(KPS) mice...
January 25, 2018: Oncogene
https://www.readbyqxmd.com/read/29363536/cell-of-origin-affects-tumour-development-and-phenotype-in-pancreatic-ductal-adenocarcinoma
#19
Alex Y L Lee, Claire L Dubois, Karnjit Sarai, Soheila Zarei, David F Schaeffer, Maike Sander, Janel L Kopp
OBJECTIVE: Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive tumour thought to arise from ductal cells via pancreatic intraepithelial neoplasia (PanIN) precursor lesions. Modelling of different genetic events in mice suggests both ductal and acinar cells can give rise to PDAC. However, the impact of cellular context alone on tumour development and phenotype is unknown. DESIGN: We examined the contribution of cellular origin to PDAC development by inducing PDAC-associated mutations, KrasG12D expression and Trp53 loss, specifically in ductal cells ( Sox9CreER;KrasLSL-G12D ;Trp53flox/flox (' Duct:KPcKO ')) or acinar cells ( Ptf1aCreER ;KrasLSL-G12D ;Trp53flox/flox (' Acinar:KPcKO ')) in mice...
January 23, 2018: Gut
https://www.readbyqxmd.com/read/29352660/clinical-significance-of-muc13-in-pancreatic-ductal-adenocarcinoma
#20
Sheema Khan, Nadeem Zafar, Shabia S Khan, Saini Setua, Stephen W Behrman, Zachary E Stiles, Murali M Yallapu, Peeyush Sahay, Hemendra Ghimire, Tomoko Ise, Satoshi Nagata, Lei Wang, Jim Y Wan, Prabhakar Pradhan, Meena Jaggi, Subhash C Chauhan
BACKGROUND: Poor prognosis of pancreatic cancer (PanCa) is associated with lack of an effective early diagnostic biomarker. This study elucidates significance of MUC13, as a diagnostic/prognostic marker of PanCa. METHODS: MUC13 was assessed in tissues using our in-house generated anti-MUC13 mouse monoclonal antibody and analyzed for clinical correlation by immunohistochemistry, immunoblotting, RT-PCR, computational and submicron scale mass-density fluctuation analyses, ROC and Kaplan Meir curve analyses...
January 15, 2018: HPB: the Official Journal of the International Hepato Pancreato Biliary Association
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