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https://www.readbyqxmd.com/read/29350079/differences-in-home-blood-pressure-and-pulse-rates-between-singleton-and-twin-pregnancies
#1
Yukiko Mikami, Yasushi Takai, Sumiko Era, Yoshihisa Ono, Masahiro Saitoh, Kazunori Baba, Hiromichi Suzuki, Hiroyuki Seki
Objectives To evaluate home blood pressure (HBP) measurements during pregnancy and postpartum and investigate differences between singleton and twin pregnancies. Methods This prospective study involved normotensive, pregnant women who were planning to give birth at Saitama Medical Centre, Saitama, Japan between September 2013 and March 2017. HBP and pulse rate were measured twice daily and clinical blood pressure values were determined from patient records. Results HBP values were available from 101 participants; 69 women with singleton and 32 women with twin pregnancies...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29334905/efficacy-comparison-of-multi-phase-ct-and-hepatotropic-contrast-enhanced-mri-in-the-differential-diagnosis-of-focal-nodular-hyperplasia-a-prospective-cohort-study
#2
Tomasz K Nowicki, Karolina Markiet, Ewa Izycka-Swieszewska, Katarzyna Dziadziuszko, Michal Studniarek, Edyta Szurowska
BACKGROUND: Different clinical behaviour influences the importance of differentiating focal nodular hyperplasia (FNH) from other focal liver lesions (FLLs). The aim of this study was to compare the efficacy of contrast-enhanced CT and MRI in the diagnosis of FNH. METHODS: 157 patients with equivocal FLLs detected in ultrasonography subsequently underwent multi-phase CT and MRI with the use of hepatotropic contrast agent (Gd-BOPTA) in a 1.5 T scanner. Examinations were evaluated by three independent readers...
January 15, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29332014/influence-of-waist-circumference-on-blood-pressure-status-in-non-obese-adolescents
#3
Karima Benmohammed, Paul Valensi, Minh Tuan Nguyen, Farah Benmohammed, Moufida Benlatreche, Karima Benembarek, Alkassem Lezzar
Objectives To check whether excess in abdominal adiposity and metabolic factors were associated with blood pressure abnormalities in non-obese adolescents. Methods We randomly selected 1100 adolescent students, aged 12-18 years, from schools and classrooms in the city of Constantine, Algeria. Among them 179 were overweight and 51 were obese (IOTF criteria). Waist circumference (WC) was considered high if >74 cm in boys and 75 cm in girls (mean of WC of all population studied). Hypertension (HBP) and prehypertension (preHBP) were defined by the NHBPEP's 2004 criteria...
January 15, 2018: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29321963/a-critical-role-of-hepatitis-b-virus-polymerase-in-cirrhosis-hepatocellular-carcinoma-and-steatosis
#4
Hea-Jong Chung, Xiao Chen, Yang Yu, Heui-Kwan Lee, Chang Ho Song, Han Choe, Seungkoo Lee, Hyeon-Jin Kim, Seong-Tshool Hong
Hepatitis B is one of the most common infectious diseases in the world; more than 350 million people are carriers of hepatitis B virus (HBV). Chronic HBV infection (CHB) leads to liver diseases such as cirrhosis, hepatocellular carcinoma (HCC), and steatosis. Despite its seriousness in terms of public health, the pathogenic mechanism of how CHB leads to liver diseases, especially cirrhosis and steatosis, remains unclear. We studied the role of HBV polymerase (HBp) reverse transcriptase (RT) activity in association with the pathogenesis of liver diseases in CHB by developing transgenic mice expressing HBp or the RT domain of HBp...
January 2018: FEBS Open Bio
https://www.readbyqxmd.com/read/29288710/hbp-induces-the-expression-of-monocyte-chemoattractant-protein-1-via-the-fak-pi3k-akt-and-p38-mapk-nf-%C3%AE%C2%BAb-pathways-in-vascular-endothelial-cells
#5
Mengling Chang, Feng Guo, Zengding Zhou, Xiaoqin Huang, Lei Yi, Yi Dou, Jingning Huan
Inflammation is characterized by early influx of polymorphonuclear neutrophils (PMNs), followed by a second wave of monocyte recruitment. PMNs mediate monocyte recruitment via their release of heparin binding protein (HBP), which activates CCR2 (CC-chemokine receptor 2) on monocytes. However, the pathways for such signal transmission remain unknown. Accumulating evidences have highlighted the importance of leukocyte-endothelial cell interactions in the initiation of inflammation. In this study, an interesting finding is that HBP enhances the secretion of monocyte chemotactic protein 1(MCP-1), ligand of CCR2, from a third party, the endothelial cells (ECs)...
December 27, 2017: Cellular Signalling
https://www.readbyqxmd.com/read/29287200/gramine-attenuates-egfr-mediated-inflammation-and-cell-proliferation-in-oral-carcinogenesis-via-regulation-of-nf-%C3%AE%C2%BAb-and-stat3-signaling
#6
Arunkumar Ramu, Suresh Kathiresan, Hemavardhini Ramadoss, Anandhi Nallu, Ramachandran Kaliyan, Theerthu Azamuthu
Gramine, a natural indole alkaloid found in Hordeum vulgare has been possesses anti-mutagenic properties. The aim of the present study was to evaluate the effect of gramine on inflammation and proliferation in 7,12-dimethylbenz[a]anthracene(DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. Epidermal growth factor receptor (EGFR) tyrosine kinase phosphorylation trigged PI3K/Akt/mTOR and JAK signaling that activates NF-κB and STAT3. In contrast, gramine suppressed EGFR tyrosine kinase phosphorylation and simultaneously inhibiting PI3K/Akt/mTOR and JAK phosphorylation, thereby blockage NF-κB and STAT3 nuclear translocation...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29287195/-6-shogaol-attenuates-inflammation-cell-proliferation-via-modulate-nf-%C3%AE%C2%BAb-and-ap-1-oncogenic-signaling-in-7-12-dimethylbenz-a-anthracene-induced-oral-carcinogenesis
#7
Govindhan Annamalai, Kathiresan Suresh
Nuclear factor-kappaB (NF-κB) and activator protein 1 (AP-1) is a major transcription factor which regulates many biological and pathological processes such as inflammation and cell proliferation, which are major implicates in cancer progression. [6]-Shogaol ([6]-SHO) is a major constituent of ginger, exhibits various biological properties such as anti-oxidants, anti-inflammation and anti-tumor. Recently, we proven that [6]-SHO prevents oral squamous cell carcinoma by activating proapoptotic factors in in vitro and in vivo experimental model...
December 26, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29283972/prognostic-significance-of-day-by-day-variability-of-home-blood-pressure-on-progression-to-macroalbuminuria-in-patients-with-diabetes
#8
Emi Ushigome, Shinobu Matsumoto, Chikako Oyabu, Noriyuki Kitagawa, Toru Tanaka, Goji Hasegawa, Masayoshi Ohnishi, Sei Tsunoda, Hidetaka Ushigome, Isao Yokota, Naoto Nakamura, Yohei Oda, Mai Asano, Muhei Tanaka, Masahiro Yamazaki, Michiaki Fukui
OBJECTIVES: Previously, we have shown in cross-sectional analysis of patients with type 2 diabetes mellitus that the presence of diabetic nephropathy is associated with increased home blood pressure (HBP) variability. We now examine the prognostic significance of HBP variability in substantially the same cohort. METHODS: We performed a prospective cohort study of type 2 diabetes patients. We analyzed 714 patients. Major exclusion criteria are missing data of urinary albumin excretion and newly prescribed or stopped renin-angiotensin system inhibitors during 2-year follow-up...
December 27, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29278765/gd-eob-dtpa-enhanced-t1%C3%AF-imaging-vs-diffusion-metrics-for-assessment-liver-inflammation-and-early-stage-fibrosis-of-nonalcoholic-steatohepatitis-in-rabbits
#9
Yuanliang Xie, Hongfeng Zhang, Chaoling Jin, Xiang Wang, Xiaoqi Wang, Jingting Chen, Yikai Xu
To assess the value of T1ρ,T1ρ on hepatobiliary phase (HBP) and diffusion metrics in staging of Non-alcoholic fatty liver disease (NAFLD) activity scores, inflammation, fibrosis in NASH rabbits model. Non-alcoholic steatohepatitis (NASH) rabbits model was induced by feeding a varied duration of high-fat, high-cholesterol diet. T1ρ,T1ρ (HBP) 20min after administration of Gd-EOB-DTPA, and Intravoxel incoherent motion imaging (IVIM) diffusion-weighted imaging were performed on a 3.0T magnetic resonance (MR) imaging unit...
December 23, 2017: Magnetic Resonance Imaging
https://www.readbyqxmd.com/read/29274474/permanent-his-bundle-pacing-long-term-lead-performance-and-clinical-outcomes
#10
Pugazhendhi Vijayaraman, Angela Naperkowski, Faiz A Subzposh, Mohamed Abdelrahman, Parikshit S Sharma, Jess W Oren, Gopi Dandamudi, Kenneth A Ellenbogen
BACKGROUND: Right ventricular pacing (RVP) is associated with heart failure and increased mortality. His bundle pacing (HBP) is a physiological alternative to RVP. OBJECTIVE: The aim of our study is to report long-term performance and compare the clinical outcomes of permanent HBP to RVP. METHODS: All patients requiring pacemaker implantation underwent attempt at permanent HBP in 2011 at one hospital and RV pacing at the sister hospital. Patients were followed from implantation, 2 weeks, 2 months and yearly for 5 years...
December 20, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29250866/hyperbranched-aliphatic-polyester-via-cross-metathesis-polymerization-synthesis-and-postpolymerization-modification
#11
Fu-Rong Zeng, Ji-Mei Ma, Lin-Hao Sun, Zhen Zeng, Hong Jiang, Zi-Long Li
A novel postpolymerization modification methodology is demonstrated to achieve selective functionalization of hyperbranched polymer (HBP). Terminal and internal acrylates of HBP derived from cross-metathesis polymerization (CMP) are functionalized in a chemoselective fashion using the thiol-Michael chemistries. Model reactions between different thiols (benzyl mercaptan and methyl thioglycolate) and acrylates (n-hexyl acrylate and ethyl trans-2-decenoate) by using dimethylphenylphosphine or amylamine as the catalyst are investigated to optimize the modification protocol for HBP...
December 18, 2017: Macromolecular Rapid Communications
https://www.readbyqxmd.com/read/29234393/reduced-mlh3-expression-in-the-syndrome-of-gan-shen-yin-deficiency-in-patients-with-different-diseases
#12
Juan Du, Maofeng Zhong, Dong Liu, Shufang Liang, Xiaolin Liu, Binbin Cheng, Yani Zhang, Zifei Yin, Yuan Wang, Changquan Ling
Traditional Chinese medicine formulates treatment according to body constitution (BC) differentiation. Different constitutions have specific metabolic characteristics and different susceptibility to certain diseases. This study aimed to assess the characteristic genes of gan-shen Yin deficiency constitution in different diseases. Fifty primary liver cancer (PLC) patients, 94 hypertension (HBP) patients, and 100 diabetes mellitus (DM) patients were enrolled and classified into gan-shen Yin deficiency group and non-gan-shen Yin deficiency group according to the body constitution questionnaire to assess the clinical manifestation of patients...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29230554/correction-to-differentiating-focal-nodular-hyperplasia-from-hepatocellular-adenoma-is-hepatobiliary-phase-mri-hbp-mri-using-linear-gadolinium-chelates-always-useful
#13
Marion Roux, Frederic Pigneur, Laurence Baranes, Julien Calderaro, Mélanie Chiaradia, Thomas Decaens, Sandrine Kastahian, Anaïs Charles-Nelson, Lambros Tselikas, Charlotte Costentin, Alexis Laurent, Daniel Azoulay, Ariane Mallat, Alain Rahmouni, Alain Luciani
The original version of this article unfortunately contained a mistake. There was an error in the last sentence of the summary and the last sentence of the discussion. It should read as "On HBP, all FNH appeared hyper- or iso-intense compared to adjacent liver while close to 97% of HCA appeared hypointense".
December 11, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29227474/a-proteolytic-fragment-of-histone-deacetylase-4-protects-the-heart-from-failure-by-regulating-the-hexosamine-biosynthetic-pathway
#14
Lorenz H Lehmann, Zegeye H Jebessa, Michael M Kreusser, Axel Horsch, Tao He, Mariya Kronlage, Matthias Dewenter, Viviana Sramek, Ulrike Oehl, Jutta Krebs-Haupenthal, Albert H von der Lieth, Andrea Schmidt, Qiang Sun, Julia Ritterhoff, Daniel Finke, Mirko Völkers, Andreas Jungmann, Sven W Sauer, Christian Thiel, Alexander Nickel, Michael Kohlhaas, Michaela Schäfer, Carsten Sticht, Christoph Maack, Norbert Gretz, Michael Wagner, Ali El-Armouche, Lars S Maier, Juan E Camacho Londoño, Benjamin Meder, Marc Freichel, Hermann-Josef Gröne, Patrick Most, Oliver J Müller, Stephan Herzig, Eileen E M Furlong, Hugo A Katus, Johannes Backs
The stress-responsive epigenetic repressor histone deacetylase 4 (HDAC4) regulates cardiac gene expression. Here we show that the levels of an N-terminal proteolytically derived fragment of HDAC4, termed HDAC4-NT, are lower in failing mouse hearts than in healthy control hearts. Virus-mediated transfer of the portion of the Hdac4 gene encoding HDAC4-NT into the mouse myocardium protected the heart from remodeling and failure; this was associated with decreased expression of Nr4a1, which encodes a nuclear orphan receptor, and decreased NR4A1-dependent activation of the hexosamine biosynthetic pathway (HBP)...
December 11, 2017: Nature Medicine
https://www.readbyqxmd.com/read/29225931/community-preferences-for-a-social-health-insurance-benefit-package-an-exploratory-study-among-the-uninsured-in-vietnam
#15
Hoa Thi Nguyen, Tinh Viet Luu, Gerald Leppert, Manuela De Allegri
Understanding public preferences in terms of health benefit packages (HBPs) remains limited, yet gathering community insights is an important endeavour when developing people-centred health systems and moving towards universal health coverage. Our study aimed to address this gap in knowledge by eliciting community preferences for the social health insurance benefit package among the uninsured in Vietnam. We adopted a mixed methods approach that included a ranking exercise followed by focus group discussions...
2017: BMJ Global Health
https://www.readbyqxmd.com/read/29220422/atrioventricular-node-ablation-and-his-bundle-pacing
#16
Pugazhendhi Vijayaraman, Faiz A Subzposh, Angela Naperkowski
Aims: Atrioventricular node ablation (AVNA) and right ventricular pacing (RVP) are effective therapies for patients with atrial fibrillation (AF) and rapid ventricular rates. His bundle pacing (HBP) is a physiologic alternative to RVP. The aim of our study is to assess the feasibility and safety of HBP in patients undergoing AVNA and its effect on left ventricular (LV) function. Methods and results: Permanent HBP is the preferred form of ventricular pacing at our institute...
December 1, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29204729/-nutrient-sensing-and-self-renewal-o-glcnac-in-a-new-role
#17
REVIEW
Nikita S Sharma, Ashok K Saluja, Sulagna Banerjee
Whether embryonic, hematopoietic or cancer stem cells, this metabolic reprogramming is dependent on the nutrient-status and bioenergetic pathways that is influenced by the micro-environmental niches like hypoxia. Thus, the microenvironment plays a vital role in determining the stem cell fate by inducing metabolic reprogramming. Under the influence of the microenvironment, like hypoxia, the stem cells have increased glucose and glutamine uptake which result in activation of hexosamine biosynthesis pathway (HBP) and increased O-GlcNAc Transferase (OGT)...
December 5, 2017: Journal of Bioenergetics and Biomembranes
https://www.readbyqxmd.com/read/29178672/glycolysis-and-the-hexosamine-biosynthetic-pathway-as-novel-targets-for-upper-and-lower-airway-inflammation
#18
REVIEW
Young Hyo Kim, Tsuguhisa Nakayama, Jayakar Nayak
Glycolysis is a process that rapidly converts glucose to lactate to produce adenosine triphosphate (ATP) under anaerobic conditions and occurs in all eukaryotic and prokaryotic cells. On the other hand, the hexosamine biosynthetic pathway (HBP) converts glucose to intermediate products like UDP-N-acetylglucosamine, which is critical for post-translational modifications of proteins, such as protein glycosylation. These 2 pathways are well known to contribute to glucose metabolism, but recent studies indicate modulation of these pathways can alter immune system function...
January 2018: Allergy, Asthma & Immunology Research
https://www.readbyqxmd.com/read/29172715/the-rationale-and-design-of-reduction-of-uncontrolled-hypertension-by-remote-monitoring-and-telemedicine-remote-study
#19
Midori Sasaki Yatabe, Junichi Yatabe, Kei Asayama, Jan A Staessen, Blerim Mujaj, Lutgarde Thijs, Kyotaro Ito, Tomohiro Sonoo, Satoshi Morimoto, Atsuhiro Ichihara
PURPOSE: Although self-measurement of home blood pressure (HBP) is common in Japan and HBP telemonitoring via the Internet is possible, whether telemonitoring improves HBP control better than conventional practice remains unclear. Furthermore, hypertension care with online communication using telemonitored HBP is feasible, whereas the efficacy and safety of such telemedicine have not been established. We aim to compare traditional care, care with office visits using HBP telemonitoring, and antihypertensive telemedicine based on HBP telemonitoring...
November 27, 2017: Blood Pressure
https://www.readbyqxmd.com/read/29166246/imaging-features-of-gadoxetic-acid-enhanced-and-diffusion-weighted-mr-imaging-for-identifying-cytokeratin-19-positive-hepatocellular-carcinoma-a-retrospective-observational-study
#20
Seo-Youn Choi, Seong Hyun Kim, Cheol Keun Park, Ji Hye Min, Ji Eun Lee, Yoon-Hyeong Choi, Bo Ra Lee
Purpose To determine the preoperative magnetic resonance (MR) imaging findings potentially most useful for predicting cytokeratin 19 (CK19)-positive hepatocellular carcinoma (HCC) and to evaluate the prognosis after curative resection in patients with a single HCC lesion positive for CK19 compared with patients with HCC who are negative for CK19. Materials and Methods The institutional review board approved this study and waived the requirement for informed consent. Two hundred four patients with CK19-negative HCC and 38 with CK19-positive HCC who underwent curative resection after gadoxetic acid-enhanced and diffusion-weighted MR imaging were retrospectively evaluated in a single institution...
November 21, 2017: Radiology
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