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Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran
The microbial etiology and source of sepsis influence the inflammatory response. Therefore, the plasma levels of cytokines (IL-6, IL-8, and IL-10), chemokines (CCL2/MCP-1, MIP-1 β ), heparin-binding protein (HBP), soluble CD14 (sCD14), and cortisol were analyzed in blood from septic patients obtained during the first 96 hours of intensive care unit hospitalization. The etiology was established in 56 out of a total of 62 patients enrolled in the study. Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n = 10) and infective endocarditis (IE; n = 11) compared to those with bacterial meningitis (BM; n = 18)...
2018: Mediators of Inflammation
Christopher L Camp, Dean Wang, Alec S Sinatro, John D'Angelo, Struan H Coleman, Joshua S Dines, Stephen Fealy, Stan Conte
BACKGROUND: Although batters are frequently hit by pitch (HBP) in baseball, the effect of HBP injuries remains undefined in the literature. PURPOSE: To determine the effect of HBP injuries in terms of time out of play, injury patterns resulting in the greatest time out of play, and the value of protective gear such as helmets and elbow pads. STUDY DESIGN: Descriptive laboratory study. METHODS: Based on the Major League Baseball (MLB) Health and Injury Tracking System, all injuries to batters HBP during the 2011-2015 MLB and Minor League Baseball (MiLB) seasons were identified and analyzed...
May 1, 2018: American Journal of Sports Medicine
Weiruo Zhang, Gina Bouchard, Alice Yu, Majid Shafiq, Mehran Jamali, Joseph B Shrager, Kelsey Ayers, Shaimaa Bakr, Andrew J Gentles, Maximilian Diehn, Andrew Quon, Robert B West, Viswam Nair, Matt van de Rijn, Sandy Napel, Sylvia K Plevritis
Metabolic reprogramming of the tumor microenvironment is recognized as a cancer hallmark. To identify new molecular processes associated with tumor metabolism, we analyzed the transcriptome of bulk and flow-sorted human primary non-small cell lung cancer (NSCLC) together with 18FDG-positron emission tomography scans, which provide a clinical measure of glucose uptake. Tumors with higher glucose uptake were functionally enriched for molecular processes associated with invasion in adenocarcinoma (AD) and cell growth in squamous cell carcinoma (SCC)...
May 14, 2018: Cancer Research
Kousuke Ishino, Mitsuhiro Kudo, Wei-Xia Peng, Shoko Kure, Kiyoko Kawahara, Kiyoshi Teduka, Yoko Kawamoto, Taeko Kitamura, Takenori Fujii, Tetsushi Yamamoto, Ryuichi Wada, Zenya Naito
The glycolytic inhibitor 2-deoxy-d-glucose (2DG) causes energy starvation, affecting cell viability in a wide range of cancer cell lines. To determine the action of 2DG in pancreatic cancer, we performed proteomic analysis of pancreatic cancer cell line after 2DG treatment. Eighty proteins showed differential expression and among these, proteins involved in phosphohexose metabolism were upregulated. Up-regulation of glutamine: fructose 6-phosphate aminotransferase 1 (GFAT1), which belongs to the hexosamine biosynthesis pathway (HBP) that produces uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) to maintain glycoprotein, was validated by evaluation of mRNA and protein levels...
May 10, 2018: Biochemical and Biophysical Research Communications
Jungo Yasuda, Tomoyoshi Okamoto, Shinji Onda, Yasuro Futagawa, Katsuhiko Yanaga, Naoki Suzuki, Asaki Hattori
BACKGROUND: We previously developed an image-guided navigation system (IG-NS) using augmented reality technology for hepatobiliary and pancreatic (HBP) surgery. This system superimposed a 3D model onto a stereoscope-captured surgical field (i.e., the scope method). Unfortunately, this method requires an expensive stereoscope, surgeons have to shift their eyesight away from the surgical field, and the method has poor controllability. Therefore, an IG-NS using a tablet PC (i.e., the tablet method) was developed...
May 11, 2018: International Journal of Medical Robotics + Computer Assisted Surgery: MRCAS
Monaj Karar, Suvendu Paul, Bhaskar Biswas, Tapas Majumdar, Arabinda Mallick
Unusual self-sorting of an ion-pair under highly crowded conditions driven by a synthesized intelligent molecule 2-((E)-(3-((E)-2-hydroxy-3-methoxybenzylideneamino)-2-hydroxypropyl imino)methyl)-6-methoxyphenol, hereafter HBP, is described. When a mixture of various metal salts was allowed to react with HBP, only a specific ion-pair ZnII/AcO- in the solution simultaneously reacted, resulting in high-fidelity ion-pair recognition of HBP. This phenomenon was evidenced by significant changes in the absorption spectra and huge enhancement in emission intensity of HBP...
May 10, 2018: Dalton Transactions: An International Journal of Inorganic Chemistry
Franck Olivier Ouattara, Mikhael Laskine, Nathalie Ng Cheong, Leora Birnbaum, Robert Wistaff, Michel Bertrand, Paul van Nguyen, Christophe Kolan, Madeleine Durand, Felix Rinfret, Maxime Lamarre-Cliche
CONTEXT: Paper home blood pressure (HBP) charts are commonly brought to physicians at office visits. The precision and accuracy of mental calculations of blood pressure (BP) means are not known. METHODS: A total of 109 hypertensive patients were instructed to measure and record their HBP for 1 week and to bring their paper charts to their office visit. Study section 1: HBP means were calculated electronically and compared to corresponding in-office BP estimates made by physicians...
May 7, 2018: Blood Pressure Monitoring
Y Takatsu, M Nakamura, S Kobayashi, T Miyati
AIM: To evaluate the hepatobiliary phase (HBP) of liver magnetic resonance imaging (MRI) using gadolinium-ethoxybenzyl-diethylenetriamine penta-acetic acid, and report a visual criterion based on the portal vein (PV), which can be used as a substitute for the quantitative liver-spleen contrast ratio (Q-LSC). MATERIALS AND METHODS: In HBP images of 167 patients, a visual criterion was established based on the sufficient contrast between the liver parenchyma (LP) and PV...
April 30, 2018: Clinical Radiology
Li Xing, Lu Zhongqian, Song Chunmei, Chen Pingfa, He Lei, Jin Qin, Mu Genhua, Deng Yijun
BACKGROUND: In the early stage of sepsis, M1 macrophages result in the production of inflammatory mediators and AKI. Heparin-binding protein (HBP) have been shown to play important roles in sepsis-induced AKI. In this study, we investigate the association of HBP with M1 macrophages in sepsis-induced AKI. METHODS: Male C57BL6 mice were subjected to cecal ligation and puncture (CLP) or sham surgery. Biochemical and histological renal damage was assessed. Macrophage infiltration was assessed by immunohistochemistry...
2018: PloS One
Edouard Reizine, Giuliana Amaddeo, Frederic Pigneur, Laurence Baranes, François Legou, Sebastien Mulé, Benhalima Zegai, Vincent Roche, Alexis Laurent, Alain Rahmouni, Julien Calderaro, Alain Luciani
PURPOSE: The purpose of our study was to correlate the quantitative analysis of benign hepatocellular tumor uptake on delayed hepatobiliary phase (HBP) imaging with the quantitative level of OATP expression. METHODS: This single-center retrospective study, which took place between September 2009 and March 2015, included 20 consecutive patients with a proven pathologic and immunohistochemical (IHC) diagnosis of FNH or HCA, including quantification of the OATP expression...
May 2, 2018: European Radiology
Toshiki Kaihara, Yuki Imaizumi, Kazuo Eguchi, Kazuomi Kario
We tested the hypothesis that the maximum value of home systolic BP (MSBP) is a marker of hypertensive target organ damage (TOD). We conducted a cross-sectional study of 220 hypertensives. The subjects performed HBP monitoring using a telemonitoring system and measured their HBP for 7 days. Mean, maximum, standard deviation, and coefficient of variation of SBPs were used as independent variables. Brachial-ankle pulse wave velocity, left ventricular mass index (LVMI), mean carotid intima-media thickness, and left atrial diameter index (LADI) were used as dependent variables...
May 1, 2018: Journal of Human Hypertension
Yubo Liu, Yu Cao, Xiaoqing Pan, Meiyun Shi, Qiong Wu, Tianmiao Huang, Hui Jiang, Wenli Li, Jianing Zhang
Chemoresistance has become a major obstacle to the success of cancer therapy, but the mechanisms underlying chemoresistance are not yet fully understood. O-GlcNAcylation is a post-translational modification that is regulated by the hexosamine biosynthetic pathway (HBP) and has an important role in a wide range of cellular functions. Here we assessed the role of O-GlcNAcylation in chemoresistance and investigated the underlying cellular mechanisms. The results showed that the HBP has an important role in cancer cell chemoresistance by regulating O-GlcNAcylation...
April 30, 2018: Cell Death & Disease
Francesco Zanon, Kenneth A Ellenbogen, Gopi Dandamudi, Parikshit S Sharma, Weijian Huang, Daniel L Lustgarten, Roderick Tung, Hiroshi Tada, Jayanthi N Koneru, Tracy Bergemann, Dedra H Fagan, John Harrison Hudnall, Pugazhendhi Vijayaraman
Aims: Permanent cardiac pacing of the His-bundle restores and retains normal electrical activation of the ventricles. Data on His-bundle pacing (HBP) are largely limited to small single-centre reports, and clinical benefits and risks have not been systematically examined. We sought to systematically examine published studies of patients undergoing permanent HBP and quantify the benefits and risks of the therapy. Methods and results: PubMed, Embase, and Cochrane Library were searched for full-text articles on permanent HBP...
April 26, 2018: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Paulo Rogério Melo Rodrigues, Rosangela Alves Pereira, Augusta Gama, Isabel Mourão Carvalhal, Helena Nogueira, Vitor Rosado-Marques, Cristina Padez
OBJECTIVE: The aim of the study was to estimate the prevalence of high blood pressure (HBP) and its association with anthropometric indicators of adiposity in Portuguese schoolchildren. METHODS: In this cross-sectional study, a nationally representative sample of 6-9-year-old children was analyzed. Weight and height (used to calculate body mass index [BMI]), blood pressure (BP), waist circumference (WC) and skinfold thickness (used to estimate body fat percentage [BFP]) were measured using standard techniques...
April 20, 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
Yang Liu, Shaolin Ma, Xuebin Wang, Yajing Feng, Shouqin Zhang, Sheng Wang, Xiangyu Zhang
AIMS: PMNs (polymorphonuclear neutrophil) play important roles in early stage of inflammation induced ARDS (Acute Respiratory Distress Syndrome). Both HBP (Heparin-Binding Protein) released from active PMNs and β2 integrins on the surface of PMNs are involved in vascular leakage. The role and relationship of HBP and β2 integrins on ARDS still requires study. MATERIALS AND METHODS: We established ARDS model using C57BL/6 mice with cecal ligation and puncture and eliminating HBP and β2 integrin with respective antibodies...
April 18, 2018: Life Sciences
Wanle Sheng, Yayang Wu, Changjiang Yu, Petia Bobadova-Parvanova, Erhong Hao, Lijuan Jiao
Annularly fused azaBODIPY-based organic fluorophores (HBPs 2) containing up to 13 aromatic ring fusions were synthesized by a Suzuki coupling reaction with bromoazadipyrromethenes and a subsequent regioselective oxidative ring-fusion reaction. X-ray analysis indicates almost planar dipyrrin cores for all crystals but overall curved or "wave" conformations for those HBP dyes. These molecules exhibit unique structural and physical properties including excellent spectral selectivity (negligible absorption between 300 and 700 nm), sharp near-infrared (NIR) absorption (up to 878 nm) and emission (up to 907 nm), large extinction coefficient (up to 4...
April 18, 2018: Organic Letters
Shinichi Murata, Shigeru Matsushima, Yozo Sato, Hidekazu Yamaura, Mina Kato, Takaaki Hasegawa, Kei Muro, Yoshitaka Inaba
PURPOSE: This study aimed to predict the treatment response for colorectal liver metastases (CLM) using relative tumor enhancement (RTE) of the hepatobiliary phase (HBP) for patients with no history of chemotherapy. MATERIALS AND METHODS: In this retrospective study, we enrolled 26 patients [14 males, 12 females; median age: 58 years (range 37-82 years)] with CLM and no history of chemotherapy between December 2011 and May 2017. Gadoxetic acid-enhanced magnetic resonance imaging was performed before starting chemotherapy and RTE of HBP...
April 17, 2018: Abdominal Radiology
Andrea Solís, Jaime Cerda, Claudia González
INTRODUCTION: Extremely premature children have a higher incidence of High Blood Pressure (HBP) and risk of renal damage due to decreased glomerular count with consequent hyperfiltration of the remnants. OBJECTIVES: To assess the prevalence of altered blood pressure values in outpatient measurement and ambulatory blood pressure monitoring (ABPM) in preterm infants ≤ 32 weeks and/ or ≤ 1,500 g birth weight between 5 and 7 years of age, as well as the presence of early renal damage markers...
February 2018: Revista Chilena de Pediatría
Ji Liu, Cindy Soo Yun Tan, Oren A Scherman
Supramolecular building block, such as cucurbit[n]uril (CB[n])-based host-guest complexes, have been extensively studied at the nano- and microscale as adhesion promoters. Herein, we exploit a new class of CB[n]-threaded highly-branched polyrotaxanes (HBP-CB[n]) as aqueous adhesives to macroscopically bond two wet surfaces, including biological tissue, through the formation of CB[8] heteroternary complexes. The dynamic nature of these complexes gives rise to adhesion with remarkable self-healing, displaying recovery and re-adhesion after mechanical failure at the interface...
April 16, 2018: Angewandte Chemie
Jessica Ochalek, Paul Revill, Gerald Manthalu, Finn McGuire, Dominic Nkhoma, Alexandra Rollinger, Mark Sculpher, Karl Claxton
Malawi, like many low-income and middle-income countries, has used health benefits packages (HBPs) to allocate scarce resources to key healthcare interventions. With no widely accepted method for their development, HBPs often promise more than can be delivered, given available resources. An analytical framework is developed to guide the design of HBPs that can identify the potential value of including and implementing different interventions. It provides a basis for informing meaningful discussions between governments, donors and other stakeholders around the trade-offs implicit in package design...
2018: BMJ Global Health
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