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https://www.readbyqxmd.com/read/28542517/revisiting-the-discriminatory-accuracy-of-traditional-risk-factors-in-preeclampsia-screening
#1
Merida Rodriguez-Lopez, Philippe Wagner, Raquel Perez-Vicente, Fatima Crispi, Juan Merlo
BACKGROUND: Preeclampsia (PE) is associated with a high risk of perinatal morbidity and mortality. However, there is no consensus in the definition of high-risk women. AIM: To question current definition of high PE risk and propose a definition that considers individual heterogeneity to improves risk classification. METHODS: A stratified analysis by parity was conducted using the Swedish Birth Register between 2002-2010 including 626.600 pregnancies...
2017: PloS One
https://www.readbyqxmd.com/read/28542467/genetic-variations-in-sterol-regulatory-element-binding-protein-cleavage-activating-protein-scap-are-associated-with-blood-pressure-in-overweight-obese-chinese-children
#2
Yi-De Yang, Jie-Yun Song, Shuo Wang, Fang-Hong Liu, Yi-Ning Zhang, Xiao-Rui Shang, Hai-Jun Wang, Jun Ma
OBJECTIVE: Previous studies demonstrated a role of variations in sterol regulatory element binding protein (SREBP) cleavage-activating protein (SCAP) in obesity and blood lipids. But the associations between SCAP polymorphisms and blood pressure (BP) are not clear. This study aimed to investigate the relationship between genetic variations in SCAP and BP phenotypes in a Chinese pediatric population. METHODS: A case-control study on 702 high blood pressure (HBP) children and 1319 controls was conducted to explore the correlation between single nucleotide polymorphism markers (rs12487736 and rs12490383) of SCAP and BP phenotypes...
2017: PloS One
https://www.readbyqxmd.com/read/28541700/chemical-synthesis-of-d-glycero-d-manno-heptose-1-7-bisphosphate-and-evaluation-of-its-ability-to-modulate-nf-%C3%AE%C2%BAb-activation
#3
Shinsuke Inuki, Toshihiko Aiba, Shota Kawakami, Taishin Akiyama, Jun-Ichiro Inoue, Yukari Fujimoto
d-glycero-d-manno-Heptose 1,7-bisphosphate (HBP) is the precursor for heptose residues found in Gram-negative bacterial membrane surface glycoproteins and glycolipids. HBP β-anomer was recently reported to be a pathogen-associated molecular pattern (PAMP) that regulates TIFA-dependent immunity. Herein, we report the chemical synthesis of HBP α- and β-anomers, which highlights a C-7 carbon homologation via the Corey-Chaykovsky reaction, and the introduction of a phosphate group at the anomeric position using the Mitsunobu reaction...
May 25, 2017: Organic Letters
https://www.readbyqxmd.com/read/28533882/-idiopathic-nephrotic-syndrome-ins-in-children-in-dakar-about-40-cases
#4
Younoussa Keita, Ahmed Tall Lemrabott, Assane Sylla, Babacar Niang, El Hadji Fary Ka, Chérif Mohamed Dial, Aliou Abdoulaye Ndongo, Amadou Sow, Claude Moreira, Abdou Niang, Ousmane Ndiaye, Boucar Diouf, Mouhamadou Guélaye Sall
INTRODUCTION: This study aimed to analyze the diagnostic, therapeutic, and evolutionary features of nephrosis in children in a pediatric department in Dakar. METHODS: The study was carried out in the Department of Pediatrics at the Aristide Le Dantec Hospital. We conducted a retrospective study over a period of 3 years from 1 January 2012 to 31 December 2014. All patients aged 2-12 years with idiopathic nephrotic syndrome were included in the study. RESULTS: Forty cases of nephrosis were collected, that is to say a prevalence of 23% among patients with kidney disease treated in the Department of Pediatrics...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28532444/haemoglobin-level-increase-as-an-efficacy-biomarker-during-axitinib-treatment-for-metastatic-renal-cell-carcinoma-a-retrospective-study
#5
Alison C Johnson, Margarida Matias, Helen Boyle, Bernard Escudier, Alicia Molinier, Brigitte Laguerre, Carole Helissey, Pierre-Emmanuel Brachet, Audrey Emmanuelle Dugué, Loic Mourey, Elodie Coquan, Florence Joly
BACKGROUND: Axitinib is used after failure of first line treatment for metastatic renal cell carcinoma (mRCC). A known side effect is the increase of haemoglobin level (HbL) during treatment with a suspected correlation with better outcome. Our objective was to examine whether HbL increase during the first three months of axitinib treatment is associated with better prognosis. METHODS: Retrospective multicentre analysis including patients with mRCC treated with axitinib for at least three months from 2012 to 2014...
May 22, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28532405/red-meat-and-chicken-consumption-and-its-association-with-high-blood-pressure-and-obesity-in-south-korean-children-and-adolescents-a-cross-sectional-analysis-of-kshes-2011-2015
#6
Geum Hee Kim, Sang Won Shin, Juneyoung Lee, Jun Hyun Hwang, Soon-Woo Park, Jin Soo Moon, Hyun Jung Kim, Hyeong Sik Ahn
BACKGROUND: The impact of meat consumption on high blood pressure (HBP) and obesity in children and adolescents is a subject of debate. The aim of this study was thus to evaluate the association between meat consumption and both HBP and obesity in this group. METHODS: We performed a cross-sectional analysis using nationally representative samples of children and adolescents aged 9, 12, and 15 years old (n = 136,739) who were included in the Korea School Health Examination Survey (KSHES) for the 2011-2015 period...
May 22, 2017: Nutrition Journal
https://www.readbyqxmd.com/read/28520751/-do-it-yourself-home-blood-pressure-as-a-predictor-of-traditional-and-everyday-cognition-in-older-adults
#7
Sophie E Yeung, Wendy Loken Thornton
BACKGROUND: Hypertension guidelines recommend home blood pressure (HBP) monitoring in adjunct to office blood pressure (OBP) for its greater reproducibility and prognostic utility in the prevention of cardiovascular outcomes, especially stroke. To date, the relationship between HBP and cognitive function remains unexplored. METHODS: We examined HBP as a cognitive predictor in a multi-ethnic group of community-dwelling adults aged 60 and over (N = 133) using neuropsychological measures and analyzed the data using multiple regression analyses...
2017: PloS One
https://www.readbyqxmd.com/read/28515436/nimbolide-upregulates-reck-by-targeting-mir-21-and-hif-1%C3%AE-in-cell-lines-and-in-a-hamster-oral-carcinogenesis-model
#8
Jaganathan Kowshik, Rajakishore Mishra, Josephraj Sophia, Satabdi Rautray, Kumaraswamy Anbarasu, G Deepak Reddy, Madhulika Dixit, Sundarasamy Mahalingam, Siddavaram Nagini
Reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a potent inhibitor of matrix metalloproteinases (MMPs) is a common negative target of oncogenic signals and a potential therapeutic target for novel drug development. Here, we show that sequential RECKlessness stimulates angiogenesis and Notch signalling in the 7,12-dimethylbenz[a]anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis model, a paradigm for oral oncogenesis and chemointervention. We also report the chemotherapeutic effect of nimbolide, a limonoid from the neem tree (Azadirachta indica) based on the upregulation of RECK as well as modulation of the expression of key molecules involved in invasion and angiogenesis...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28514661/innate-recognition-of-intracellular-bacterial-growth-is-driven-by-the-tifa-dependent-cytosolic-surveillance-pathway
#9
Ryan G Gaudet, Cynthia X Guo, Raphael Molinaro, Haila Kottwitz, John R Rohde, Anne-Sophie Dangeard, Cécile Arrieumerlou, Stephen E Girardin, Scott D Gray-Owen
Intestinal epithelial cells (IECs) act as sentinels for incoming pathogens. Cytosol-invasive bacteria, such as Shigella flexneri, trigger a robust pro-inflammatory nuclear factor κB (NF-κB) response from IECs that is believed to depend entirely on the peptidoglycan sensor NOD1. We found that, during Shigella infection, the TRAF-interacting forkhead-associated protein A (TIFA)-dependent cytosolic surveillance pathway, which senses the bacterial metabolite heptose-1,7-bisphosphate (HBP), functions after NOD1 to detect bacteria replicating free in the host cytosol...
May 16, 2017: Cell Reports
https://www.readbyqxmd.com/read/28483680/preoperative-gadoxetic-acid-enhanced-mri-for-predicting-microvascular-invasion-in-patients-with-single-hepatocellular-carcinoma
#10
Sunyoung Lee, Seong Hyun Kim, Ji Eun Lee, Dong Hyun Sinn, Cheol Keun Park
BACKGROUND & AIMS: This study aimed to identify preoperative magnetic resonance (MR) imaging biomarkers for predicting microvascular invasion (MVI) and to determine their diagnostic performance and evaluate whether they are associated with early recurrence after surgery for single hepatocellular carcinoma (HCC). METHODS: The study included 197 patients with surgically resected HCC (≤ 5 cm) who underwent preoperative gadoxetic acid-enhanced MR imaging. Significant MR imaging findings for predicting MVI were identified on univariate and multivariate analyses...
May 5, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/28470052/multimodal-hydrogel-based-platform-to-deliver-and-monitor-cardiac-progenitor-stem-cell-engraftment
#11
Alessondra T Speidel, Daniel J Stuckey, Lesley W Chow, Laurence H Jackson, Michela Noseda, Marta Abreu Paiva, Michael D Schneider, Molly M Stevens
Retention and survival of transplanted cells are major limitations to the efficacy of regenerative medicine, with short-term paracrine signals being the principal mechanism underlying current cell therapies for heart repair. Consequently, even improvements in short-term durability may have a potential impact on cardiac cell grafting. We have developed a multimodal hydrogel-based platform comprised of a poly(ethylene glycol) network cross-linked with bioactive peptides functionalized with Gd(III) in order to monitor the localization and retention of the hydrogel in vivo by magnetic resonance imaging...
April 26, 2017: ACS Central Science
https://www.readbyqxmd.com/read/28457829/the-number-of-visits-and-blood-pressure-measurements-influence-the-prevalence-of-high-blood-pressure-in-adolescents
#12
Luciano Machado Ferreira Tenório de Oliveira, Alison Oliveira da Silva, Paula Rejane Beserra Diniz, Breno Quintella Farah, André Luiz Torres Pirauá, Antônio José de Lima Neto, Wallacy Milton do Nascimento Feitosa, Rafael Miranda Tassitano, Raphael M Ritti-Dias
The aim of this study was to analyze the influence of the number of visits and the number of blood pressure (BP) measurements on the prevalence of high blood pressure (HBP) in adolescents. A cross-sectional epidemiologic study with 481 adolescents (14-19 years old) selected using a random cluster sampling strategy. We measured the BP three times in a first visit. Adolescents with HBP performed subsequent visits. The final calculation of BP followed four strategies: the 1st measure, mean of 1st and 2nd measurements, mean of all three measurements, and averaging the 2nd and 3rd measurements...
April 13, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28457144/molecular-effects-of-hesperetin-a-citrus-flavanone-on7-12-dimethylbenz-a-anthracene-induced-buccal-pouch-squamous-cell-carcinoma-in-golden-syrian-hamsters
#13
Sukumar Babukumar, Veerasamy Vinothkumar, Periyannan Velu, Duraisamy Ramachandhiran, Madhavan Ramados Nirmal
In recent years, researchers have been focused on citrus flavanone, a naturally occurring bioactive substance of hesperetin. To investigate the molecular mechanism based chemopreventive efficacy of hesperetin on 7,12-dimethylbenz(a)anthracene (DMBA) induced hamster buccal pouch (HBP) squamous cell carcinoma (SCC). The oral tumour was provoked by painted with 0.5% DMBA on left buccal pouch thrice a week for 10 consecutive weeks developed well-differentiated SCC and tumour formation was 100% in DMBA alone. We evaluated the chemopreventive potential of hesperetin by assessing the lipid peroxidation (LPO) by-products, status of enzymatic, non-enzymatic antioxidants, detoxifying agents etc...
May 1, 2017: Archives of Physiology and Biochemistry
https://www.readbyqxmd.com/read/28412868/prevalence-of-pre-high-blood-pressure-and-high-blood-pressure-among-non-overweight-children-and-adolescents-using-international-blood-pressure-references-in-developed-regions-china
#14
Changwei Tian, Shuang Xu, Hua Wang, Wenming Wang, Hui Shen
BACKGROUND: There is a lack of data on the prevalence of pre high blood pressure (PreHBP) and high blood pressure (HBP), based on recent international blood pressure references, in non-overweight children and adolescents. AIM: To describe the prevalence of PreHBP and HBP in non-overweight children and adolescents in developed regions of China. SUBJECTS AND METHODS: 588,097 non-overweight children and adolescents aged 6-17 years from National Surveys on Chinese Students' Constitution and Health in 2015 were included...
April 16, 2017: Annals of Human Biology
https://www.readbyqxmd.com/read/28400315/permanent-his-bundle-pacing-for-cardiac-resynchronization-therapy-initial-feasibility-study-in-lieu-of-left-ventricular-lead
#15
Olujimi A Ajijola, Gaurav Upadhyay, Carlos Macias, Kalyanam Shivkumar, Roderick Tung
BACKGROUND: Permanent His-bundle pacing (HBP) has the potential to physiologically normalize wide QRS duration in patients with bundle branch block and cardiomyopathy. OBJECTIVE: The purpose of this study was to assess the feasibility of incorporating a His-bundle lead for cardiac resynchronization therapy (CRT) in lieu of a coronary sinus lead. METHODS: Patients with an indication for CRT (n = 21) underwent attempted implantation of an HBP placed into the left ventricular (LV) lead port...
April 8, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/28396918/comparison-of-10-and-20-min-hepatobiliary-phase-images-on-gd-eob-dtpa-enhanced-mri-t1-mapping-for-liver-function-assessment-in-clinic
#16
Zhi-Peng Zhou, Li-Ling Long, Wei-Jia Qiu, Ge Cheng, Li-Juan Huang, Teng-Fei Yang, Zhong-Kui Huang
PURPOSE: To compare hepatobiliary phase (HBP) images obtained 10 and 20 min after Gd-EOB-DTPA-enhanced MRI for liver function assessment in clinic on 3.0 T MR imaging. METHODS: 103 patients were separated into four groups: 38 patients for the normal liver function (NLF) group, 33 patients for the liver cirrhosis with Child-Pugh A (LCA) group, 21 patients for the liver cirrhosis with Child-Pugh B group, and 11 patients for a liver cirrhosis with Child-Pugh C group...
April 10, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28395463/-the-combined-effect-of-spermarche-menarche-and-obesity-on-elevated-blood-pressure-among-chinese-students
#17
Y Song, J Ma, B Zhang, P J Hu
Objective: To investigate the association between the combined effect of spermarche/menarche and obesity with elevated blood pressure among Chinese students. Methods: A total of 106 009 primary and secondary school students (55 614 boys and 50 395 girls) were selected from " 2014 National Physical Fitness and Health Surveillance" (including 31 provinces, with the exception of Hong Kong, Macao, and Taiwan) with full record of height, weight, blood pressure, puberty development data of spermarche/menarche. The level of blood pressure, as well as the prevalence of high blood pressure(HBP), were compared between different subgroups (pre-spermarche/menarche and non-obesity group, pre-spermarche/menarche and obesity group, pro-spermarche/menarche and non-obesity group, pro-spermarche/menarche and obesity group), and mulilevel logistic model was used to investigate the relationship between puberty development, obesity and blood pressure...
April 6, 2017: Zhonghua Yu Fang Yi Xue za Zhi [Chinese Journal of Preventive Medicine]
https://www.readbyqxmd.com/read/28385233/cellulose-polymer-silica-composite-cotton-fiber-based-on-a-hyperbranch-mesostructure-system-as-versatile-adsorbent-for-water-treatment
#18
Jin Tao, Jiaqing Xiong, Chenlu Jiao, Desuo Zhang, Hong Lin, Yuyue Chen
The present study describes the preparation of a hybrid cellulose-based adsorbent (HM-cotton) containing a dot-plane composite adsorption system. The dot-plane adsorption structure is formed by the plane of hyperbranched polymer (HBP) layer distributed by the functional mesoporous nanoparticle (CA-MSN) dots, fabricating hyperbranch-mesostructure system via self-assembly. The resultant adsorbent HM-cotton was characterized, and the adsorption mechanism for dyes and metal ions was also discussed in detail. The results show that the adsorption data is fitted to Pseudo-second-order kinetic model and Langmuir isotherm model, and owing to the dot-plane system possessing functional mesostructure of CA-MSNs with large surface area and substantial adsorption sites from HBP macromolecules, HM-cotton exhibits versatile, highly-efficiency and sustainable adsorption properties for dyes such as CR and MB, and metal ions such as Fe(3+) and Cu(2+) from aqueous media...
June 15, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28374073/liver-imaging-reporting-and-data-system-on-ct-and-gadoxetic-acid-enhanced-mri-with-diffusion-weighted-imaging
#19
Dong Ik Cha, Kyung Mi Jang, Seong Hyun Kim, Tae Wook Kang, Kyoung Doo Song
OBJECTIVES: To assess major imaging features of Liver Imaging Reporting and Data System (LI-RADS) on contrast-enhanced CT and gadoxetic acid-enhanced MRI and to estimate whether the combination of signal intensity favouring HCC on hepatobiliary phase (HBP) and diffusion-weighted images (DWI) can act as a major feature in LI-RADS. METHODS: Four hundred twenty one patients with 445 observations were included. Major features of LI-RADS on CT and MRI as well as HBP and DWI features were assessed...
April 3, 2017: European Radiology
https://www.readbyqxmd.com/read/28371248/randomized-controlled-trial-of-perioperative-antimicrobial-therapy-based-on-the-results-of-preoperative-bile-cultures-in-patients-undergoing-biliary-reconstruction
#20
Kunishige Okamura, Kimitaka Tanaka, Takumi Miura, Yoshitsugu Nakanishi, Takehiro Noji, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura, Toshiaki Shichinohe, Satoshi Hirano
BACKGROUND: The high frequency of surgical site infections (SSIs) after hepato-pancreato-biliary (HPB) surgery is a problem that needs to be addressed. This prospective, randomized, controlled study examined whether perioperative prophylactic use of antibiotics based on preoperative bile culture results in HPB surgery could decrease SSI. METHODS: Participants comprised 126 patients who underwent HPB (bile duct, gallbladder, ampullary, or pancreatic) cancer surgery with biliary reconstruction at Hokkaido University Hospital between August 2008 and March 2013 (UMIN Clinical Trial Registry #00001278)...
March 29, 2017: Journal of Hepato-biliary-pancreatic Sciences
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