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https://www.readbyqxmd.com/read/28811347/tifa-signaling-in-gastric-epithelial-cells-initiates-the-cag-type-4-secretion-system-dependent-innate-immune-response-to-helicobacter-pylori-infection
#1
Alevtina Gall, Ryan G Gaudet, Scott D Gray-Owen, Nina R Salama
Helicobacter pylori is a bacterial pathogen that colonizes the human stomach, causing inflammation which, in some cases, leads to gastric ulcers and cancer. The clinical outcome of infection depends on a complex interplay of bacterial, host genetic, and environmental factors. Although H. pylori is recognized by both the innate and adaptive immune systems, this rarely results in bacterial clearance. Gastric epithelial cells are the first line of defense against H. pylori and alert the immune system to bacterial presence...
August 15, 2017: MBio
https://www.readbyqxmd.com/read/28801576/disrupting-glutamine-metabolic-pathways-to-sensitize-gemcitabine-resistant-pancreatic-cancer
#2
Ru Chen, Lisa A Lai, Yumi Sullivan, Melissa Wong, Lei Wang, Jonah Riddell, Linda Jung, Venu G Pillarisetty, Teresa A Brentnall, Sheng Pan
Pancreatic cancer is a lethal disease with poor prognosis. Gemcitabine has been the first line systemic treatment for pancreatic cancer. However, the rapid development of drug resistance has been a major hurdle in gemcitabine therapy leading to unsatisfactory patient outcomes. With the recent renewed understanding of glutamine metabolism involvement in drug resistance and immuno-response, we investigated the anti-tumor effect of a glutamine analog (6-diazo-5-oxo-L-norleucine) as an adjuvant treatment to sensitize chemoresistant pancreatic cancer cells...
August 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28792285/awareness-and-management-of-elevated-blood-pressure-among-human-immunodeficiency-virus-infected-adults-receiving-antiretroviral-therapy-in-urban-zambia-a-call-to-action
#3
Sophie Bauer, Mwanza Wa Mwanza, Roma Chilengi, Charles B Holmes, Zude Zyambo, Hansjakob Furrer, Matthias Egger, Gilles Wandeler, Michael J Vinikoor
The prevalence of high blood pressure (HBP) and hypertension (HTN), awareness of the diagnoses, and use of anti-hypertensive drugs were examined among human immunodeficiency virus (HIV)-infected individuals on antiretroviral therapy (ART) in Zambia's capital Lusaka. Within a prospective cohort based at two public sector ART clinics, BP was measured at ART initiation and every 6 months thereafter as a routine clinic procedure. Predictors of HBP (systolic BP ≥140 mmHg or diastolic BP ≥90 mmHg) during one year on ART were analyzed using logistic regression, and the proportion with HTN (2+ episodes of HBP >3 months apart) described...
2017: Global Health Action
https://www.readbyqxmd.com/read/28789606/-pharming-out-support-a-promising-approach-to-integrating-clinical-pharmacists-into-established-primary-care-medical-home-practices
#4
Kimberly D Brunisholz, Jeff Olson, Jonathan W Anderson, Emily Hays, Peggy M Tilbury, Bradley Winter, Josh Rickard, Sharon Hamilton, Gregory Parkin
Objective Embedding clinical pharmacists into ambulatory care settings needs to be assessed in the context of established medical home models. Methods A retrospective, observational study examined the effectiveness of the Intermountain Healthcare Collaborative Pharmacist Support Services (CPSS) program from 2012-2015 among adult patients diagnosed with diabetes mellitus (DM) and/or high blood pressure (HBP). Patients who attended this program were considered the intervention (CPSS) cohort. These patients were matched using propensity scores with a reference group (no-CPSS cohort) to determine the effect of achieving disease management goals and time to achievement...
January 1, 2017: Journal of International Medical Research
https://www.readbyqxmd.com/read/28782471/tgf-%C3%AE-1-causes-emt-by-regulating-n-acetyl-glucosaminyl-transferases-via-downregulation-of-non-muscle-myosin-ii-a-through-jnk-p38-pi3k-pathway-in-lung-cancer
#5
Ghulam Jilany Khan, Yingsheng Gao, Ming Gu, Lai Wang, Sara Khan, Farah Naeem, Bashir Alsiddig Yousef, Debmalya Roy, Herve Semukunzi, Shengtao Yuan, Li Sun
BACKGROUND: Epithelial to mesenchymal transition (EMT) is a major determinant of cancer metastasis and is closely linked with TGF-β1. Intracellular proteins, including E. Cadherin, N. Cadherin and Vimentin are directly related to EMT that affect cell migration and adhesion; on the other hand, non muscle myosin (NM) has a central role in cytokinesis, migration and adhesion. OBJECTIVE: We aimed to explore the association of EMT and metastasis with TGF-β1 through regulation of non-muscle myosin II-A (NMII-A) and its interaction with Hexosamine Biosynthesis Pathway (HBP)...
August 7, 2017: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/28777132/prognostic-value-of-average-home-blood-pressure-and-variability-19-year-follow-up-of-the-didima-study
#6
Angeliki Ntineri, Petros G Kalogeropoulos, Konstantinos G Kyriakoulis, Evaggelia K Aissopou, Georgia Thomopoulou, Anastasios Kollias, George S Stergiou
OBJECTIVE: The current general population study explored the prognostic value of home blood pressure (HBP) average and variability (BPV) versus office measurements (OBP). METHODS: In 1997, 665 adults of Didima, Argolida, Greece were evaluated with OBP (two visits, six readings) and HBP (3 days, 12 readings) measurements. Total mortality and cardiovascular morbidity and mortality (CVD) were assessed after 19.0 ± 1.4 years. BPV was quantified by using SD and coefficient of variation...
August 1, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28773860/a-facile-in-situ-and-uv-printing-process-for-bioinspired-self-cleaning-surfaces
#7
Marina A González Lazo, Ioannis Katrantzis, Sara Dalle Vacche, Feyza Karasu, Yves Leterrier
A facile in situ and UV printing process was demonstrated to create self-cleaning synthetic replica of natural petals and leaves. The process relied on the spontaneous migration of a fluorinated acrylate surfactant (PFUA) within a low-shrinkage acrylated hyperbranched polymer (HBP) and its chemical immobilization at the polymer-air interface. Dilute concentrations of 1 wt. % PFUA saturated the polymer-air interface within 30 min, leading to a ten-fold increase of fluorine concentration at the surface compared with the initial bulk concentration and a water contact angle (WCA) of 108°...
August 30, 2016: Materials
https://www.readbyqxmd.com/read/28761907/feasibility-and-reproducibility-of-liver-surface-nodularity-quantification-for-the-assessment-of-liver-cirrhosis-using-ct-and-mri
#8
Grace C Lo, Cecilia Besa, Michael J King, Martin Kang, Ashley Stueck, Swan Thung, Mathilde Wagner, Andrew D Smith, Bachir Taouli
PURPOSE: To assess intra-observer, inter-observer and inter-modality (CT vs. MRI) reproducibility of liver surface nodularity (LSN) scores measured with software used for detection of liver fibrosis. METHODS: This IRB-approved retrospective study included patients with both abdominal CT and MRI within 6 months of histopathologic sampling. Two independent observers used post-processing software to quantify LSN scores on axial non-contrast CT (NCT), axial contrast-enhanced CT (CECT), axial T2-weighted (T2W) HASTE, and axial and coronal post-gadoxetic acid T1-weighted (T1W) images obtained during the hepatobiliary phase (HBP)...
2017: European Journal of Radiology Open
https://www.readbyqxmd.com/read/28760004/hepatocellular-carcinoma-with-central-scar-on-gadoxetic-acid-enhanced-and-diffusion-weighted-magnetic-resonance-imaging
#9
Sol Bee Han, Young Kon Kim, Ji Hye Min, Sang Yun Ha, Woo Kyung Jeong, Won Jae Lee
Background Central scars are rarely reported in conventional hepatocellular carcinoma (HCC). The presence of central scars on imaging might lead to erroneous diagnosis of hepatic tumors. Purpose To determine imaging features of HCC with central scars on magnetic resonance imaging (MRI) including gadoxetic acid-enhanced and diffusion-weighted imaging (DWI). Material and Methods Fifty-one patients with 51 surgically confirmed HCCs with central scars (fibrotic scar: n = 50; myxoid scar: n = 1; range = 1...
January 1, 2017: Acta Radiologica
https://www.readbyqxmd.com/read/28747271/diagnostic-accuracy-of-split-bolus-single-phase-contrast-enhanced-cone-beam-ct-for-the-detection-of-liver-tumors-before-transarterial-chemoembolization
#10
Martin Jonczyk, Julius Chapiro, Federico Collettini, Dominik Geisel, Dirk Schnapauff, Florian Streitparth, Thomas Schmidt, Bernd Hamm, Bernhard Gebauer, Gero Wieners
PURPOSE: To evaluate detectability of hepatocellular carcinoma (HCC) using split-bolus cone-beam CT in intraindividual comparison between cone-beam CT and contrast-enhanced MR imaging. MATERIALS AND METHODS: In a retrospective, single-center study, 28 patients with 85 HCC tumors were treated with transarterial chemoembolization between May 2015 and June 2016. All patients underwent arterial and hepatobiliary phase (HBP) MR imaging within 1 month before transarterial chemoembolization...
July 23, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28739686/chemoprevention-by-quercetin-of-oral-squamous-cell-carcinoma-by-suppression-of-the-nf-%C3%AE%C2%BAb-signaling-pathway-in-dmba-treated-hamsters
#11
Wen Zhang, Gang Yin, Jianguo Dai, Y U Sun, Robert M Hoffman, Zhijian Yang, Yuan Fan
BACKGROUND/AIM: The aim of this study was to investigate the effects of the flavonoid quercetin on chemoprevention of oral squamous cell carcinoma (OSCC). The study involved molecular signaling pathways in 7,12-dimethylbenz(a) anthracene (DMBA)-induced hamster buccal pouch (HBP) carcinogenesis. MATERIALS AND METHODS: DMBA (0.5%) was painted at the right buccal pouches of hamsters for 14 weeks to induce carcinoma. DMBA-treated hamsters received simultaneous doses of quercetin...
August 2017: Anticancer Research
https://www.readbyqxmd.com/read/28738697/reduction-of-heart-rate-variability-in-hypertensive-elderly
#12
Paulo Evaristo de Andrade, Joice Anaize Tonon do Amaral, Laércio da Silva Paiva, Fernando Adami, Juliana Zangirolami Raimudo, Vitor Engrácia Valenti, Luiz Carlos de Abreu, Rodrigo Daminello Raimundo
INTRODUCTION: The elderly population grows globally every day, and along with it the incidence of high blood pressure also grows, following these data scientists seek tools to improve the health of this population, a widely used tool for assessing cardiovascular function is the heart rate variability(HRV), that is a mecanism that allows the investigation of oscillations in the intervals between consecutive heart beats (RR intervals). There are already studies on the autonomic nervous system in the elderly population, however, these studies investigated normotensive patients and there is little research in hypertensive patients...
July 24, 2017: Blood Pressure
https://www.readbyqxmd.com/read/28728485/factors-associated-with-global-longitudinal-strain-decline-in-hypertensive-patients-with-normal-left-ventricular-ejection-fraction
#13
Nabila Soufi Taleb Bendiab, Abderrahim Meziane-Tani, Souhila Ouabdesselam, Nadera Methia, Samia Latreche, Latefa Henaoui, Jean-Jacques Monsuez, Salim Benkhedda
Background Early detection of risk factors for left ventricular (LV) dysfunction may be useful in patients with high blood pressure (HBP). Methods Patient from an outpatient HBP clinic underwent a two-dimensional Doppler-coupled echocardiography with determination of LV global longitudinal strain (GLS) by speckle-tracking. Results Among 200 patients (mean age 61.7 ± 9.7 years), 155 were overweight, 93 had diabetes, 83 had dyslipidemia, and 109 had uncontrolled HBP. LV hypertrophy (LVH) was found in 136 patients (68%), including concentric ( n = 106) and eccentric ( n = 30) LVH...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28725327/prevalence-of-undiagnosed-cardiovascular-risk-factors-in-adults-aged-20-40-a-cross-sectional-study-in-2016-in-jeddah-saudi-arabia
#14
Faisal Saed Alharthi, Jamilah Saad Alrahimi, Abdulrahman Ali Alotaibi, Daniah Ahmed Alhamdi, Bashair Mohammed Ibrahim, Yasmina Aymen Badeeb
BACKGROUND: Cardiovascular diseases (CVDs) are the first leading cause of death worldwide. In Saudi Arabia, CVDs are the major killers with a mortality rate of 46%. CVD risk factors are not exclusive to old populations. Thus, the purpose of this study was to approximately find the prevalence of these risk factors, particularly high blood pressure (HBP), high blood glucose (HBG), obesity, and smoking. METHODS: This cross-sectional was conducted in May 2016 and took place in the Ambulatory Care Center of King Abdulaziz Medical City, Jeddah...
June 2017: Cardiology Research
https://www.readbyqxmd.com/read/28722313/cellular-glycosylation-senses-metabolic-changes-and-modulates-cell-plasticity-during-emt
#15
REVIEW
P Carvalho-Cruz, F Alisson-Silva, A R Todeschini, W B Dias
Epithelial to mesenchymal transition (EMT) is a developmental program reactivated by tumor cells that leads to the switch from epithelial to mesenchymal phenotype. During EMT, cells are transcriptionally regulated to decrease E-cadherin expression while expressing mesenchymal markers such as vimentin, fibronectin and N-cadherin. Growing body of evidences suggest that cells engaged in EMT undergo a metabolic reprograming process, redirecting glucose flux toward Hexosamine Biosynthesis Pathway (HBP) which fuels aberrant glycosylation patterns that are extensively observed in cancer cells...
July 19, 2017: Developmental Dynamics: An Official Publication of the American Association of Anatomists
https://www.readbyqxmd.com/read/28715499/helicobacter-pylori-modulates-host-cell-responses-by-cagt4ss-dependent-translocation-of-an-intermediate-metabolite-of-lps-inner-core-heptose-biosynthesis
#16
Saskia C Stein, Eugenia Faber, Simon H Bats, Tatiana Murillo, Yvonne Speidel, Nina Coombs, Christine Josenhans
Highly virulent Helicobacter pylori cause proinflammatory signaling inducing the transcriptional activation and secretion of cytokines such as IL-8 in epithelial cells. Responsible in part for this signaling is the cag pathogenicity island (cagPAI) that codetermines the risk for pathological sequelae of an H. pylori infection such as gastric cancer. The Cag type IV secretion system (CagT4SS), encoded on the cagPAI, can translocate various molecules into cells, the effector protein CagA, peptidoglycan metabolites and DNA...
July 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28678544/possible-involvement-of-orphan-receptors-gpr88-and-gpr124-in-the-development-of-hypertension-in-spontaneously-hypertensive-rat
#17
L Calderón-Zamora, A Ruiz-Hernandez, R Romero-Nava, N León-Sicairos, A Canizalez-Román, E Hong, F Huang, S Villafaña
Hypertension (HBP) is a chronic disease characterized by increased blood pressure, which despite several treatments maintains a high morbi-mortality, which suggests that there are other mechanisms involved in this pathology, within which the orphan receptors could be candidates for the treatment of the HBP; these receptors are called orphan receptors because their ligand is unknown. These receptors have been suggested to participate in some pathologies because they are associated with various systems such as GPR88, which has been linked to the dopaminergic system, and GPR124 with angiogenesis, suggesting that these receptors could take part in HBP...
July 5, 2017: Clinical and Experimental Hypertension: CHE
https://www.readbyqxmd.com/read/28651555/prevalence-of-high-blood-pressure-subtypes-and-its-associations-with-bmi-in-chinese-children-a-national-cross-sectional-survey
#18
Yide Yang, Bin Dong, Shuo Wang, Yanhui Dong, Zhiyong Zou, Lianguo Fu, Jun Ma
BACKGROUND: Data on prevalence and characteristics of different high blood pressure subtypes are lacking among Chinese children. Regarding the mechanistic differences between isolated systolic high blood pressure and isolated diastolic high blood pressure and their different impact on end organ diseases, it is necessary to examine the prevalence of different high blood pressure subtypes in Chinese children and explore their associations with adiposity. METHODS: Data were derived from the baseline data of a multi-centered cluster randomized controlled trial involving participants from China...
June 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28645872/two-obesity-susceptibility-loci-in-lyplal1-and-etv5-independently-associated-with-childhood-hypertension-in-chinese-population
#19
Duo Lv, Dan Zhou, Yan Zhang, Shuai Zhang, Yi-Min Zhu
AIMS: Genome-wide association studies have identified novel obesity-associated susceptibility loci. Associations of these variants with childhood obesity have been studied in our previous research. The purpose of this study is to investigate if these loci are associated with hypertension being independent of obesity in Chinese children and adolescents. METHODS: Nineteen candidate SNPs were genotyped using Sequenom MassARRAY platform among Chinese children (N=2954, 514 hypertension and 2440 controls, aged 7-17years)...
June 20, 2017: Gene
https://www.readbyqxmd.com/read/28644127/mpi-depletion-enhances-o-glcnacylation-of-p53-and-suppresses-the-warburg-effect
#20
Nataly Shtraizent, Charles DeRossi, Shikha Nayar, Ravi Sachidanandam, Liora S Katz, Adam Prince, Anna P Koh, Adam Vincek, Yoav Hadas, Yujin Hoshida, Donald K Scott, Efrat Eliyahu, Hudson H Freeze, Kirsten C Sadler, Jaime Chu
Rapid cellular proliferation in early development and cancer depends on glucose metabolism to fuel macromolecule biosynthesis. Metabolic enzymes are presumed regulators of this glycolysis-driven metabolic program, known as the Warburg effect; however, few have been identified. We uncover a previously unappreciated role for Mannose phosphate isomerase (MPI) as a metabolic enzyme required to maintain Warburg metabolism in zebrafish embryos and in both primary and malignant mammalian cells. The functional consequences of MPI loss are striking: glycolysis is blocked and cells die...
June 23, 2017: ELife
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