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https://www.readbyqxmd.com/read/29140900/associations-between-bmi-change-and-cardiometabolic-risk-in-retired-football-players
#1
Eric T Trexler, Abbie E Smith-Ryan, J D DeFreese, Stephen W Marshall, Kevin M Guskiewicz, Zachary Y Kerr
PURPOSE: Elevated rates of cardiometabolic diseases have been observed in former American football players. The current study sought to determine if change in body mass index (ΔBMI) following retirement influences the prevalence of coronary heart disease (CHD), diabetes, or high blood pressure (HBP) in former professional football players. METHODS: Retired professional football players (n=3,729) were sent a survey with questions regarding health status, playing history, and demographic information...
November 14, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29116801/effects-of-surface-charge-of-hyperbranched-polymers-on-cytotoxicity-dynamic-cellular-uptake-and-localization-hemotoxicity-and-pharmacokinetics-in-mice
#2
Liyu Chen, Joshua D Simpson, Adrian V Fuchs, Barbara E Rolfe, Kristofer J Thurecht
Nanoscaled polymeric materials are increasingly being investigated as pharmaceutical products, drug/gene delivery vectors, or health-monitoring devices. Surface charge is one of the dominant parameters that regulates nanomaterial behavior in vivo. In this paper, we demonstrated how control over chemical synthesis allowed manipulation of nanoparticle surface charge, which in turn greatly influenced the in vivo behavior. Three methacrylate/methacrylamide-based monomers were used to synthesize well-defined hyperbranched polymers (HBP) by reversible addition-fragmentation chain transfer (RAFT) polymerization...
November 8, 2017: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29111401/biofilm-production-is-not-associated-with-poor-clinical-outcome-in-485-patients-with-staphylococcus-aureus-bacteremia
#3
María Guembe, Beatriz Alonso, José Lucio, María Jesús Pérez-Granda, Raquel Cruces, Carlos Sánchez-Carrillo, Ana Fernández-Cruz, Emilio Bouza
OBJECTIVE: Staphylococcus aureus biofilm may constitute a major cause of virulence. Our main objective was to analyze whether there was an association between biofilm production and poor outcome in patients with S. aureus bacteremia. METHODS: We studied 485 S. aureus strains isolated from the blood of patients with bacteremia from 2012 to 2015. We assessed in vitro biomass production using the crystal violet assay (CV) and metabolic activity using the tetrazolium salt assay (XTT)...
October 27, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/29111008/management-of-blood-pressure-in-acute-stroke-comparison-of-current-prescribing-patterns-with-aha-asa-guidelines-in-a-sub-saharan-african-referral-hospital
#4
C Kuate-Tegueu, J J Dongmo-Tajeuna, J Doumbe, Y Mapoure-Njankouo, G Noubissi, V D P Djientcheu
BACKGROUND: High blood pressure (HBP) is common at acute phase of stroke. It may reflect untreated or uncontrolled hypertension before stroke, or it may relate to stress response. The present study was designed to compare current American Stroke Association (ASA) guidelines with actual prescribing patterns for management of HBP at the acute phase of stroke, in a tertiary care Hospital in Douala, Cameroon. METHODS: This cross-sectional study was conducted in the Cardiology and Neurology department of the Douala Laquintinie Hospital...
November 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/29110059/differentiating-focal-nodular-hyperplasia-from-hepatocellular-adenoma-is-hepatobiliary-phase-mri-hbp-mri-using-linear-gadolinium-chelates-always-useful
#5
Marion Roux, Frederic Pigneur, Laurence Baranes, Julien Calderaro, Mélanie Chiaradia, Thomas Decaens, Sandrine Kastahian, Anaïs Charles-Nelson, Lambros Tselikas, Charlotte Costentin, Alexis Laurent, Daniel Azoulay, Ariane Mallat, Alain Rahmouni, Alain Luciani
PURPOSE: To assess the value of Hepatobiliary phase MRI (HPB-MRI) to differentiate FNH and HCA, and evaluate its impact on diagnostic accuracy, diagnostic confidence, inter-observer variability, and patient clinical management. METHODS: Forty-nine patients referred for Gd-BOPTA-enhanced MRI were retrospectively included in this IRB-approved study, with a total of 119 lesions-90 FNH and 29 HCA. Two observers separately assessed in 2 distinct randomized reading sessions the performance of MRI with (HBP-MRI) or without (conventional MRI) the use of HBP images...
November 6, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/29107697/permanent-his-bundle-pacing-hbp-recommendations-from-a-multi-center-hbp-collaborative-working-group-for-standardization-of-definitions-implant-measurements-and-follow-up
#6
Pugazhendhi Vijayaraman, Gopi Dandamudi, Francesco Zanon, Parikshit S Sharma, Roderick Tung, Weijian Huang, Jayanthi Koneru, Hiroshi Tada, Kenneth A Ellenbogen, Daniel L Lustgarten
His bundle pacing (HBP) prevents ventricular dyssynchrony and its long-term consequences by preserving normal electrical activation of the ventricles. Since the original description of permanent HBP in 2000, the adoption of HBP has increased over the last several years. However the reporting of procedural and clinical outcomes to date is not uniform. This paper is a collaboration between several implanters with significant experience in HBP to establish a uniform set of definitions encompassing the different forms of HBP, as well as define a standardized approach to gathering data endpoints to ensure consistency in reported outcomes...
October 28, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29103741/the-effect-of-home-based-program-and-outpatient-physical-therapy-in-patients-with-head-and-neck-cancer-a-randomized-controlled-trial
#7
Tsui-Ling Su, An-Ni Chen, Chau-Peng Leong, Yu-Chi Huang, Chia-Wei Chiang, I-Hsuan Chen, Yan-Yuh Lee
OBJECTIVES: Physical therapy improves outcomes for patients with head and neck cancer (HNC) but home-based program (HBP) has not yet been investigated thoroughly. This study compared a HBP with outpatient physical therapy (OPT). METHODS: This trial categorized patients with primary HNC into OPT and HBP groups. The patients in the HBP group received home-based therapy once a day for 5 days per week. By contrast, the OPT group received various physical therapies, including aerobic, anaerobic, and stretching therapies, twice per week, plus a thrice-weekly home-based therapy that similarly consisted of aerobic, anaerobic, and stretching exercises...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29100749/presence-of-benzophenones-commonly-used-as-uv-filters-and-absorbers-in-paired-maternal-and-fetal-samples
#8
M Krause, H Frederiksen, K Sundberg, F S Jørgensen, L N Jensen, P Nørgaard, C Jørgensen, P Ertberg, A Juul, K T Drzewiecki, N E Skakkebaek, A M Andersson
BACKGROUND: Previous studies have demonstrated widespread exposure of humans to certain benzophenones commonly used as UV filters or UV absorbers; some of which have been demonstrated to have endocrine disrupting abilities. OBJECTIVES: To examine whether benzophenones present in pregnant women pass through the placental barrier to amniotic fluid and further to the fetal blood circulation. METHODS: A prospective study of 200 pregnant women with simultaneously collected paired samples of amniotic fluid and maternal serum and urine...
January 2018: Environment International
https://www.readbyqxmd.com/read/29100056/regulation-of-the-hippo-yap-pathway-by-glucose-sensor-o-glcnacylation
#9
Changmin Peng, Yue Zhu, Wanjun Zhang, Qinchao Liao, Yali Chen, Xinyuan Zhao, Qiang Guo, Pan Shen, Bei Zhen, Xiaohong Qian, Dong Yang, Jin-San Zhang, Dongguang Xiao, Weijie Qin, Huadong Pei
The Hippo pathway is crucial in organ size control and tissue homeostasis, with deregulation leading to cancer. An extracellular nutrition signal, such as glucose, regulates the Hippo pathway activation. However, the mechanisms are still not clear. Here, we found that the Hippo pathway is directly regulated by the hexosamine biosynthesis pathway (HBP) in response to metabolic nutrients. Mechanistically, the core component of Hippo pathway (YAP) is O-GlcNAcylated by O-GlcNAc transferase (OGT) at serine 109. YAP O-GlcNAcylation disrupts its interaction with upstream kinase LATS1, prevents its phosphorylation, and activates its transcriptional activity...
November 2, 2017: Molecular Cell
https://www.readbyqxmd.com/read/29097724/health-related-quality-of-life-among-adults-with-and-without-hypertension-a-population-based-survey-using-eq-5d-in-shandong-china
#10
Li Zhang, Xiaolei Guo, Jiyu Zhang, Xi Chen, Chengchao Zhou, Dandan Ge, Yangyang Qian
Previous studies have focused on health-related quality of life (HRQoL) in hypertensive individuals, but few studies have attempted to compare HRQoL between hypertensive and normotensive individuals using the EQ-5D in China. Based on a survey of 3509 adults aged 18 + years, we compared HRQoL between hypertensive and normotensive individuals using a chi-square test, t-test and multi-linear regression model. The results indicated that HRQoL in hypertensive individuals was poorer than that of normotensive individuals in all domains of the EQ-5D and its utility index...
November 2, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29096347/accompanying-role-of-hepato-biliary-pancreas-surgeon-in-urological-surgery
#11
Atsushi Nanashima, Masahide Hiyoshi, Naoya Imamura, Kouichi Yano, Takeomi Hamada, Takashi Wada, Yoshiro Fujii, Fumiaki Kawano, Takuto Ikeda, Shinsuke Takeno, Eisaku Nakamura, Kunihide Nakamura, Shoichiro Mukai, Toshio Kamimura, Toshiyuki Kamoto
INTRODUCTION: The present case reports demonstrated the accompanying surgical support from hepato-biliary-pancreas (HBP) surgeons for urological surgery to secure operative safety because HBP surgeons are well experienced in dissecting techniques for mobilization of the liver or pancreas. We experienced 9 consecutive patients who underwent nephrectomy, adrenectomy or resection of retroperitoneal tumors by urological surgeons. Cardiovascular intervention was also required in cases of long tumor thrombus into the vena cava...
October 27, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29091276/simple-and-efficient-purification-of-recombinant-proteins-using-the-heparin-binding-affinity-tag
#12
Srinivas Jayanthi, Ravi Kumar Gundampati, Thallapuranam Krishnaswamy Suresh Kumar
Heparin, a member of the glycosaminoglycan family, is known to interact with more than 400 different types of proteins. For the past few decades, significant progress has been made to understand the molecular details involved in heparin-protein interactions. Based on the structural knowledge available from the FGF1-heparin interaction studies, we have designed a novel heparin-binding peptide (HBP) affinity tag that can be used for the simple, efficient, and cost-effective purification of recombinant proteins of interest...
November 1, 2017: Current Protocols in Protein Science
https://www.readbyqxmd.com/read/29081396/beneficial-effects-of-upgrading-to-his-bundle-pacing-in-chronically-paced-patients-with-left-ventricular-ejection-fraction-50
#13
Peiren Shan, Lan Su, Xiaodong Zhou, Shengjie Wu, Lei Xu, Fangyi Xiao, Xiaohong Zhou, Kenneth A Ellenbogen, Weijian Huang
BACKGROUND: Heart failure is common in patients with permanent pacemakers. Right ventricular (RV) pacing may worsen cardiac function while non-responder rate of cardiac resynchronization therapy (CRT) for heart failure treatment remains 25-30%. OBJECTIVE: This study was to assess clinical outcomes of upgrading to permanent His bundle pacing (pHBP) in heart failure patients who underwent device upgrade from RV pacing or CRT non-response. METHODS: Eighteen pacing-dependent heart failure patients with left ventricular ejection fraction (LVEF) <50% underwent pHBP attempts at device replacement...
October 25, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
https://www.readbyqxmd.com/read/29070828/high-blood-pressure-and-its-relationship-to-adiposity-in-a-school-aged-population-body-mass-index-vs-waist-circumference
#14
William Rodrigues Tebar, Raphael Mendes Ritti-Dias, Breno Quintella Farah, Edner Fernando Zanuto, Luiz Carlos Marques Vanderlei, Diego Giulliano Destro Christofaro
High blood pressure (HBP) is a major concern in pediatric populations. Adiposity is highly related to HBP in youths; however, whether body mass index (BMI) or waist circumference (WC) is more strongly associated with HBP in this population is unclear. This cross-sectional study, involving schoolchildren between 10 and 17 years of age from public and private schools, assessed direct measurements of BMI, WC and blood pressure. The socioeconomic level, sedentary behavior, physical activity, alcohol consumption and smoking history were obtained through a questionnaire...
October 26, 2017: Hypertension Research: Official Journal of the Japanese Society of Hypertension
https://www.readbyqxmd.com/read/29063251/management-of-subcentimetre-arterially-enhancing-and-hepatobiliary-hypointense-lesions-on-gadoxetic-acid-enhanced-mri-in-patients-at-risk-for-hcc
#15
Chae Jung Park, Chansik An, Sumi Park, Jin-Young Choi, Myeong-Jin Kim
OBJECTIVES: To investigate the significance of subcentimetre (≤1 cm) arterially enhancing and hepatobiliary hypointense lesions (SAELs) observed on gadoxetic acid-enhanced magnetic resonance imaging (MRI) of patients at risk of hepatocellular carcinoma (HCC). METHODS: A SAEL was defined as a subcentimetre hypervascular nodule exhibiting a hepatobiliary phase defect on gadoxetic acid-enhanced MRI. We included 52 SAELs from 46 patients in a HCC surveillance population...
October 23, 2017: European Radiology
https://www.readbyqxmd.com/read/29050339/aberrant-expression-of-oatp1b3-in-colorectal-cancer-liver-metastases-and-its-clinical-implication-on-gadoxetic-acid-enhanced-mri
#16
Seung Hyun Park, Honsoul Kim, Eun Kyung Kim, Hogeun Kim, Dong Kyu Choi, Yong Eun Chung, Myeong-Jin Kim, Jin-Young Choi
PURPOSE: To investigate the factors associated with hepatobiliary phase (HBP) enhancement at gadoxetic acid-enhanced magnetic resonance imaging (MRI) and to determine whether HBP images could be used to predict prognosis in patients with colorectal cancer liver metastasis (CRLM). RESULTS: Of the 96 total nodules, 65 and 31 nodules were in the mixed and clearly hypointense groups, respectively. In the 55 nodules without preoperative chemotherapy, organic anionic transporting polypeptide 1B3 (OATP1B3) expression was a significant factor regarding the HBP enhancement (P=0...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29047023/heparin-binding-protein-hbp-improves-prediction-of-sepsis-related-acute-kidney-injury
#17
Jonas Tverring, Suvi T Vaara, Jane Fisher, Meri Poukkanen, Ville Pettilä, Adam Linder
BACKGROUND: Sepsis-related acute kidney injury (AKI) accounts for major morbidity and mortality among the critically ill. Heparin-binding protein (HBP) is a promising biomarker in predicting development and prognosis of severe sepsis and septic shock that has recently been proposed to be involved in the pathophysiology of AKI. The objective of this study was to investigate the added predictive value of measuring plasma HBP on admission to the intensive care unit (ICU) regarding the development of septic AKI...
October 18, 2017: Annals of Intensive Care
https://www.readbyqxmd.com/read/29043368/self-coacervation-of-modular-squid-beak-proteins-a-comparative-study
#18
Hao Cai, Bartosz Gabryelczyk, Malathy S S Manimekalai, Gerhard Grüber, Stefan Salentinig, Ali Miserez
The beak of the Humboldt squid is a biocomposite material made solely of organic components - chitin and proteins - which exhibits 200-fold stiffness and hardness gradients from the soft base to the exceptionally hard tip (rostrum). The outstanding mechanical properties of the squid beak are achieved via controlled hydration and impregnation of the chitin-based scaffold by protein coacervates. Molecular-based understanding of these proteins is essential to mimic the natural beak material. Here, we present detailed studies of two histidine-rich beak proteins (HBP-1 and -2) that play central roles during beak bio-fabrication...
October 18, 2017: Soft Matter
https://www.readbyqxmd.com/read/29032943/assessing-the-validity-of-oscillometric-device-for%C3%A2-blood-pressure-measurement-in-a-large-population-based-epidemiologic-study
#19
Zuo Chen, Xin Wang, Zengwu Wang, Linfeng Zhang, Guang Hao, Ying Dong, Manlu Zhu, Runlin Gao
To evaluate the accuracy of the Omron HBP-1300, an automatic device for blood pressure (BP) measurement, compared with the standard auscultatory method with a mercury sphygmomanometer, we conducted a large population-based survey. From 2012 to 2015, a total of 500,000 participants were randomly selected from the 262 urban cities and rural counties in China, of them BP was measured three times simultaneously with mercury sphygmomanometer and Omron HBP-1300 in 37,816 participants. Bias was estimated as the average of the auscultatory measurements minus the average of the oscillometric measurements, with its corresponding 95% limits of agreement...
November 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/29031929/permanent-his-bundle-pacing-as-an-alternative-to-biventricular-pacing-for-cardiac-resynchronization-therapy-a-multi-center-experience
#20
Parikshit S Sharma, Gopi Dandamudi, Bengt Herweg, David Wilson, Rajeev Singh, Angela Naperkowski, Jayanthi N Koneru, Kenneth A Ellenbogen, Pugazhendhi Vijayaraman
INTRODUCTION: Cardiac resynchronization therapy (CRT) using biventricular pacing (BVP) is effective in patients with heart failure, bundle branch block (BBB) or right ventricular pacing. Permanent His bundle pacing (HBP) has been reported as an alternative option for CRT. OBJECTIVE: The aim of the study was to assess the feasibility and outcomes of HBP in CRT eligible or failed patients. METHODS: HBP was attempted as a rescue strategy in patients with failed LV lead or non-response to BVP (Group I); or as a primary strategy in patients with AV block, BBB, or high ventricular pacing burden as an alternative to BVP (Group II) in patients with indications for CRT...
October 11, 2017: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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