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Annunziata Panebianco, Giuseppe Carbotta, Antonio Prestera, Rita Laforgia, Annalisa Volpi, Pierluca Sallustio
AIM: Aim is to demonstrate that surgery can be the best way to reduce the risk of malignancy in choledochal cysts (CC) and how hard can be the diagnosis and the treatment during pregnancy. CASE REPORT: We report a case of a pregnant young woman (36 week) with a Todani's score II CC. After caesarean, due to increasing jaundice, she underwent magnetic resonance cholangiopancreatography (MRCP) and Endoscopic retrograde cholangiopancreatography (ERCP) that confirmed the diagnosis...
April 19, 2016: Annali Italiani di Chirurgia
Giovanni Brandi, Marzia Deserti, Francesco Vasuri, Andrea Farioli, Alessio Degiovanni, Andrea Palloni, Giorgio Frega, Maria A Barbera, Stefania de Lorenzo, Ingrid Garajova, Mariacristina Di Marco, Antonio D Pinna, Matteo Cescon, Alessandro Cucchetti, Giorgio Ercolani, Antonietta D'Errico-Grigioni, Maria A Pantaleo, Guido Biasco, Simona Tavolari
BACKGROUND: The use of gemcitabine as an adjuvant modality for cholangiocarcinoma (CC) is increasing, but limited data are available on predictive biomarkers of response. Human equilibrative nucleoside transporter 1 (hENT-1) is the major transporter involved in gemcitabine intracellular uptake. This study investigated the putative predictive role of hENT-1 localization in tumor cells of CC patients undergoing treatment with adjuvant gemcitabine. METHODS: Seventy-one consecutive patients with resected CC receiving adjuvant gemcitabine at our center were retrospectively analyzed by immunohistochemistry for hENT-1 localization in tumor cells...
May 2016: Oncologist
Vivek Bhakta Mathema, Kesara Na-Bangchang
Colangiocarcinoma (CCA) is a progressively fatal disease which generally occurs due to malignant transformation of hepatic biliary cholangiocytes. The incidence of CCA has been increasing worldwide and there is an urgent requirement for effective diagnosis and treatment strategies against this devastating disease. Different factors including liver-fluke infestation, viral hepatitis, exogenous nitrosamine-mediated DNA damage, and chronic inflammation have been linked to CCA genesis. However, the risk factors and underlying complex mechanisms leading to development of CCA are not sufficiently understood to devise an effective targeted treatment therapy...
2015: Asian Pacific Journal of Cancer Prevention: APJCP
Inês Silveira, Fernando Mota, João Pedro Ferreira, Renata Dias, Pedro Leuschner
Hepatic lesions represent a common finding in clinical practice. Bile ducts hamartomas, also known as Von Meyenburg complex, are benign hepatic malformations composed of small dilated cystic bile ducts lined by fibrous stroma. They represent a rare and asymptomatic clinic-pathological entity. Imagiological findings are variable, and may present as multiple small scattered lesions, or rarely as a single nodule. These findings may resemble secondary lesions and, although benign, there are cases of progression to colangiocarcinoma...
March 2014: Acta Médica Portuguesa
Paulo Herman, Marcos V Perini, Fabricio Coelho, William Saad, Luiz A C D'Albuquerque
INTRODUCTION: Laparoscopic liver resections are becoming a common procedure, and bleeding remains the major concern during parenchymal transection. Total vascular inflow occlusion can be performed, but ischemic reperfusion injuries can lead to postoperative morbidity. On the other hand, hemihepatic inflow occlusion, leading to hemiliver ischemia, decreases the amount of liver parenchyma submitted to reperfusion damage and offers the advantage of reduced blood loss. OBJECTIVE: The aim of this work was to describe our experience with laparoscopic the half-Pringle maneuver for segmentar or nonanatomic liver resctions...
February 2010: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
G P Cione, G Arciero, C P De Angelis, A Marano, N Farella, C Cerrone, D Cerbone, D Parmeggiani, G Cimmino, M Perrotta, D Giglio
The primitive tumors of the liver are relatively rare in the Western countries (around the 0.7% of all the neoplasms) while they present more elevated incidence in Africa and in the South Asian East. While the hepatocellular carcinoma rises up in the 50-70% of the cases in livers cirrosis, this correlation is not valid for the form of carcinoma to departure from the learned intra and extra biliar. The etiology of the intrahepatic colangiocarcinoma (CC) stays unknown. They have stayed observe, on the other hand, of the conditions sometimes correlated to the development of the CC (Carolí morbs, ulcerative colitis, asbestosis)...
May 2005: I Supplementi di Tumori: Official Journal of Società Italiana di Cancerologia ... [et Al.]
I Di Carlo, A Toro, A Basile, T Guastella, F Calanducci, D Russello, F Latteri
The Authors report the case of a patient with intrahepatic colangiocarcinoma, operated on for totally implantable arterial device (TIAD) implant in view of hepatic chemotherapy. The postoperative course was characterized by cutaneous drainage of ascites fluid from the wound of the TIAD implant. Its aetiology and therapy are discussed.
May 2003: Il Giornale di Chirurgia
T Calderón Duque, E Ortiz Oshiro, M Remezal, P González Noguera, J L Blas Layna, E Sanz Esponera, J Alvarez Fernández-Represa
Patients with choledochal cysts have an increased incidence of biliary tract carcinoma. We report a case of adenocarcinoma arising in a type I choledochal cyst which was surgically treated by resection and biliodigestive anastomosis (hepaticojejunostomy).
July 1994: Revista Española de Enfermedades Digestivas
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