keyword
MENU ▼
Read by QxMD icon Read
search

Systems biology cancer

keyword
https://www.readbyqxmd.com/read/29928206/integrated-diagnostic-model-that-incorporates-epstein-barr-virus-dna-imaging-and-nasal-endoscopy-to-stratify-primary-tumor-and-lymph-nodes-in-a-patient-with-n1-nasopharyngeal-carcinoma-multidisciplinary-management
#1
Paolo Gamba, Luigina Rota, C Abeni, Alessandra Huscher, Gabriele Saldi, Alberto Soregaroli, Elena Padolecchia, Fausto Zorzi, Mario Bignardi, Alberto Zaniboni
Nasopharyngeal carcinoma (NPC) is an epithelial malignancy, with a high metastatic potential. Epstein-Barr virus (EBV) infection plays a fundamental role, even if it is not well understood. The diagnosis of the disease in its early stage is infrequent. Imaging studies, positron emission tomography scans in addition to clinical examination, endoscopic examination, and biopsy provide information on the extent of the disease. The application of neoadjuvant chemotherapy followed by concomitant chemoradiation can improve the control of NPC...
May 2018: Case Reports in Oncology
https://www.readbyqxmd.com/read/29927717/drug-targeting-and-biomarkers-in-head-and-neck-cancers-insights-from-systems-biology-analyses
#2
Tania Islam, Rezanur Rahman, Esra Gov, Beste Turanli, Gizem Gulfidan, Anwarul Haque, Kazım Yalçın Arga, Nurul Haque Mollah
The head and neck squamous cell carcinoma (HNSCC) is one of the most common cancers in the world, but robust biomarkers and diagnostics are still not available. This study provides in-depth insights from systems biology analyses to identify molecular biomarker signatures to inform systematic drug targeting in HNSCC. Gene expression profiles from tumors and normal tissues of 22 patients with histological confirmation of nonmetastatic HNSCC were subjected to integrative analyses with genome-scale biomolecular networks (i...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29927716/identification-of-a-novel-splice-variant-of-neural-cell-adhesion-molecule-in-glioblastoma-through-proteogenomics-analysis
#3
Savita Jayaram, Lavanya Balakrishnan, Manika Singh, Azin Zabihi, Raksha A Ganesh, Kiran K Mangalaparthi, Pranali Sonpatki, Manoj Kumar Gupta, Chaitra B Amaresha, Komal Prasad, Kiran Mariswamappa, Shibu Pillai, Akhila Lakshmikantha, Nameeta Shah, Ravi Sirdeshmukh
Splice variants are known to be important in the pathophysiology of tumors, including the brain cancers. We applied a proteogenomics pipeline to identify splice variants in glioblastoma (GBM, grade IV glioma), a highly malignant brain tumor, using in-house generated mass spectrometric proteomic data and public domain RNASeq dataset. Our analysis led to the identification of a novel exon that maps to the long isoform of Neural cell adhesion molecule 1 (NCAM1), expressed on the surface of glial cells and neurons, important for cell adhesion and cell signaling...
June 2018: Omics: a Journal of Integrative Biology
https://www.readbyqxmd.com/read/29926310/role-of-autotaxin-in-cancer-stem-cells
#4
Dongjun Lee, Dong-Soo Suh, Sue Chin Lee, Gabor J Tigyi, Jae Ho Kim
Stem cells are a rare subpopulation defined by the potential to self-renew and differentiate into specific cell types. A population of stem-like cells has been reported to possess the ability of self-renewal, invasion, metastasis, and engraftment of distant tissues. This unique cell subpopulation has been designated as cancer stem cells (CSC). CSC were first identified in leukemia, and the contributions of CSC to cancer progression have been reported in many different types of cancers. The cancer stem cell hypothesis attempts to explain tumor cell heterogeneity based on the existence of stem cell-like cells within solid tumors...
June 20, 2018: Cancer Metastasis Reviews
https://www.readbyqxmd.com/read/29922633/kamikihito-improves-cancer-related-fatigue-by-restoring-balance-between-the-sympathetic-and-parasympathetic-nervous-systems
#5
Satoshi Tamada, Kyoko Ebisu, Sayaka Yasuda, Minoru Kato, Noriko Ninomiya, Takeshi Yamasaki, Taro Iguchi, Tatsuya Nakatani, Yasuyoshi Watanabe
Background: Cancer-related fatigue is one of the most prevalent symptoms that patients with cancer experience, but the mechanisms underlying it are unknown. We aimed to quantify and mechanistically evaluate the improvement in fatigue related to administration of the Kampo medicine, Kamikihito. Materials and methods: Initially, we recruited outpatients with urological diseases and compared fatigue levels of 37 patients with cancer with a control group of 23 volunteers who had recovered completely from cancer or who were being treated for dysuria...
June 2018: Prostate International
https://www.readbyqxmd.com/read/29922160/decost-a-new-approach-in-drug-repurposing-from-control-system-theory
#6
Thanh M Nguyen, Syed A Muhammad, Sara Ibrahim, Lin Ma, Jinlei Guo, Baogang Bai, Bixin Zeng
In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose. Drug repurposing has become one of the most active areas in pharmacology since the last decade. Compared to traditional drug development, drug repurposing may provide more systematic and significantly less expensive approaches in discovering new treatments for complex diseases. Although drug repurposing techniques rapidly evolve from "one: disease-gene-drug" to "multi: gene, dru" and from "lazy guilt-by-association" to "systematic model-based pattern matching," mathematical system and control paradigm has not been widely applied to model the system biology connectivity among drugs, genes, and diseases...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29922059/rna-interference-new-mechanistic-and-biochemical-insights-with-application-in-oral-cancer-therapy
#7
REVIEW
Smaranda Buduru, Alina-Andreea Zimta, Cristina Ciocan, Cornelia Braicu, Diana Dudea, Alexandra Iulia Irimie, Ioana Berindan-Neagoe
Over the last few decades, the incidence of oral cancer has gradually increased, due to the negative influence of environmental factors and also abnormalities within the genome. The main issues in oral cancer treatment consist in surpassing resistance and recurrence. However, continuous discovery of altered signaling pathways in these tumors provides valuable information for the identification of novel gene candidates targeted in personalized therapy. RNA interference (RNAi) is a natural mechanism that involves small interfering RNA (siRNA); this can be exploited in biomedical research by using natural or synthetic constructs for activation of the mechanism...
2018: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29921960/plasmonic-optical-imaging-of-gold-nanorods-localization-in-small-animals
#8
Keying Xu, Junwei Shi, Ali Pourmand, Thirupandiyur S Udayakumar, Nesrin Dogan, Weizhao Zhao, Alan Pollack, Yidong Yang
Gold nanoparticles (GNP) have been intensively investigated for applications in cancer imaging and therapy. Most imaging studies focused on microscopic imaging. Their potential as optical imaging probes for whole body small animal imaging has rarely been explored. Taking advantage of their surface plasmon resonance (SPR) properties, we aim to develop a noninvasive diffuse optical imaging method to map the distribution of a special type of GNP, gold nanorods (GNR), in small animals. We developed an integrated dual-modality imaging system capable of both x-ray computed tomography (XCT) and diffuse optical tomography (DOT)...
June 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29921600/mammary-molecular-portraits-reveal-lineage-specific-features-and-progenitor-cell-vulnerabilities
#9
Alison E Casey, Ankit Sinha, Rajat Singhania, Julie Livingstone, Paul Waterhouse, Pirashaanthy Tharmapalan, Jennifer Cruickshank, Mona Shehata, Erik Drysdale, Hui Fang, Hyeyeon Kim, Ruth Isserlin, Swneke Bailey, Tiago Medina, Genevieve Deblois, Yu-Jia Shiah, Dalia Barsyte-Lovejoy, Stefan Hofer, Gary Bader, Mathieu Lupien, Cheryl Arrowsmith, Stefan Knapp, Daniel De Carvalho, Hal Berman, Paul C Boutros, Thomas Kislinger, Rama Khokha
The mammary epithelium depends on specific lineages and their stem and progenitor function to accommodate hormone-triggered physiological demands in the adult female. Perturbations of these lineages underpin breast cancer risk, yet our understanding of normal mammary cell composition is incomplete. Here, we build a multimodal resource for the adult gland through comprehensive profiling of primary cell epigenomes, transcriptomes, and proteomes. We define systems-level relationships between chromatin-DNA-RNA-protein states, identify lineage-specific DNA methylation of transcription factor binding sites, and pinpoint proteins underlying progesterone responsiveness...
June 19, 2018: Journal of Cell Biology
https://www.readbyqxmd.com/read/29921411/potential-roles-of-reactive-oxygen-species-derived-from-chemical-substances-involved-in-cancer-development-in-the-female-reproductive-system
#10
Soo-Min Kim, Kyung-A Hwang, Kyung-Chul Choi
Reactive oxygen species (ROS) are major sources of cellular oxidative stress. Specifically, cancer cells harbor genetic alterations that promote a continuous and elevated production of ROS. While such oxidative stress conditions could be harmful to normal cells, they facilitate cancer cell growth in multiple ways by causing DNA damage and genomic instability, and ultimately, by reprogramming cancer cell metabolism. This review provides up to date findings regarding the role of ROS generation induced by diverse biological molecules and chemicals in representative women's' cancer...
June 20, 2018: BMB Reports
https://www.readbyqxmd.com/read/29921304/identification-of-hub-genes-with-prognostic-values-in-gastric-cancer-by-bioinformatics-analysis
#11
Ting Li, Xujie Gao, Lei Han, Jinpu Yu, Hui Li
BACKGROUND: Gastric cancer (GC) is a prevalent malignant cancer of digestive system. To identify key genes in GC, mRNA microarray GSE27342, GSE29272, and GSE33335 were downloaded from GEO database. METHODS: Differentially expressed genes (DEGs) were obtained using GEO2R. DAVID database was used to analyze function and pathways enrichment of DEGs. Protein-protein interaction (PPI) network was established by STRING and visualized by Cytoscape software. Then, the influence of hub genes on overall survival (OS) was performed by the Kaplan-Meier plotter online tool...
June 19, 2018: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29921293/chip-functions-as-an-oncogene-by-promoting-colorectal-cancer-metastasis-via-activation-of-mapk-and-akt-signaling-and-suppression-of-e-cadherin
#12
Jingjing Xu, Jun Zhou, Hanjue Dai, Fei Liu, Wenjing Li, Wenjuan Wang, Feng Guo
BACKGROUND: The carboxyl terminus of Hsc70-interacting protein (CHIP) is an E3 ubiquitin ligase that plays a controversial role in different cancers, either as a tumor suppressor or a tumor promoter. To date, the exact function and underlying mechanism of CHIP in colorectal cancer (CRC) is not yet clear. Here we aimed to determine whether CHIP could affect the biological behaviors of CRC cells and its underlying mechanisms. METHODS: Stably transfected CHIP overexpression and depletion DLD-1 and HT-29 cells were established using Lipofectamine 2000...
June 19, 2018: Journal of Translational Medicine
https://www.readbyqxmd.com/read/29920670/urokinase-plasminogen-activator-protects-periodontal-ligament-fibroblast-from-oxidative-induced-apoptosis-and-dna-damage
#13
M S Ahmad Akhoundi, A Rokn, R Bagheri, N Momeni, M Hodjat
BACKGROUND AND OBJECTIVE: Urokinase-plasminogen activator (uPA) is a serine protease expressed at high basal level in normal gingival cervical fluid. Despite its known pathologic role in tissue proteolysis in periodontitis, little is known concerning uPA physiological function in oral tissue. Recent evidence in cancer cells has implicated the uPA system in DNA repair and anti-apoptotic pathways. This study is aimed to evaluate the protective function of urokinase against oxidative DNA damage in periodontal ligament (PDL) fibroblast, and to propose a new biological role for uPA in oral cavity...
June 19, 2018: Journal of Periodontal Research
https://www.readbyqxmd.com/read/29917033/graphitic-and-oxidised-high-pressure-high-temperature-hpht-nanodiamonds-induce-differential-biological-responses-in-breast-cancer-cell-lines
#14
Benjamin Woodhams, Laura Ansel-Bollepalli, Jakub Surmacki, Helena Knowles, Laura Maggini, Michael de Volder, Mete Atatüre, Sarah Bohndiek
Nanodiamonds have demonstrated potential as powerful sensors in biomedicine, however, their translation into routine use requires a comprehensive understanding of their effect on the biological system being interrogated. Under normal fabrication processes, nanodiamonds are produced with a graphitic carbon shell, but are often oxidized in order to modify their surface chemistry for targeting to specific cellular compartments. Here, we assessed the biological impact of this purification process, considering cellular proliferation, uptake, and oxidative stress for graphitic and oxidized nanodiamond surfaces...
June 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29915603/notch-signaling-in-myeloid-cells-as-a-regulator-of-tumor-immune-responses
#15
REVIEW
Fokhrul Hossain, Samarpan Majumder, Deniz A Ucar, Paulo C Rodriguez, Todd E Golde, Lisa M Minter, Barbara A Osborne, Lucio Miele
Cancer immunotherapy, which stimulates or augments host immune responses to treat malignancies, is the latest development in the rapidly advancing field of cancer immunology. The basic principles of immunotherapies are either to enhance the functions of specific components of the immune system or to neutralize immune-suppressive signals produced by cancer cells or tumor microenvironment cells. When successful, these approaches translate into long-term survival for patients. However, durable responses are only seen in a subset of patients and so far, only in some cancer types...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29912175/design-and-parameter-study-of-integrated-microfluidic-platform-for-ctc-isolation-and-enquiry-a-numerical-approach
#16
Amir Shamloo, Saba Ahmad, Maede Momeni
Being the second cause of mortality across the globe, there is now a persistent effort to establish new cancer medication and therapies. Any accomplishment in treating cancers entails the existence of accurate identification systems empowering the early diagnosis. Recent studies indicate CTCs’ potential in cancer prognosis as well as therapy monitoring. The chief shortcoming with CTCs is that they are exceedingly rare cells in their clinically relevant concentration. Here, we simulated a microfluidic construct devised for immunomagnetic separation of the particles of interest from the background cells...
June 18, 2018: Biosensors
https://www.readbyqxmd.com/read/29911111/understanding-patterns-of-brain-metastasis-in-breast-cancer-and-designing-rational-therapeutic-strategies
#17
REVIEW
Evelyn M Brosnan, Carey K Anders
One of the most feared sequelae after a diagnosis of advanced breast cancer is development of metastases to the brain as this diagnosis can affect physical function, independence, relationships, quality of life, personality, and ultimately one's sense of self. The propensity to develop breast cancer brain metastases (BCBMs) varies by subtype, occurring in up to one half of those with triple negative breast cancer (TNBC), approximately a third of HER+ breast cancers and 14% in hormone positive disease. Median survival after BCBM diagnosis can be as short as 5 months in TNBC and 10-18 months in the other subtypes...
May 2018: Annals of Translational Medicine
https://www.readbyqxmd.com/read/29909706/hyaluronic-acid-doxorubicin-nanoassembly-releasing-microspheres-for-the-transarterial-chemoembolization-of-a-liver-tumor
#18
Song Yi Lee, Jin Woo Choi, Jae-Young Lee, Dae-Duk Kim, Hyo-Cheol Kim, Hyun-Jong Cho
Doxorubicin (DOX)-loaded, hyaluronic acid-ceramide (HACE) nanoassembly-releasing poly(lactic-co-glycolic acid) (PLGA) microspheres (MSs) were developed for transarterial chemoembolization (TACE) therapy of liver cancer. DOX/HACE MSs with a mean diameter of 27 μm and a spherical shape were prepared based on the modified emulsification method. Their in vitro biodegradability in artificial biological fluids was observed. A more sustained drug release pattern was observed from DOX/HACE MS than from DOX MS at pH 7...
November 2018: Drug Delivery
https://www.readbyqxmd.com/read/29908887/the-emerging-potential-for-network-analysis-to-inform-precision-cancer-medicine
#19
REVIEW
Kivilcim Ozturk, Michelle Dow, Daniel E Carlin, Rafael Bejar, Hannah Carter
Precision cancer medicine promises to tailor clinical decisions to patients using genomic information. Indeed, successes of drugs targeting genetic alterations in tumors, such as imatinib that targets BCR-ABL in chronic myelogenous leukemia, have demonstrated the power of this approach. However biological systems are complex, and patients may differ not only by the specific genetic alterations in their tumor, but by more subtle interactions among such alterations. Systems biology and more specifically, network analysis, provides a framework for advancing precision medicine beyond clinical actionability of individual mutations...
June 14, 2018: Journal of Molecular Biology
https://www.readbyqxmd.com/read/29907769/massive-expression-of-germ-cell-specific-genes-is-a-hallmark-of-cancer-and-a-potential-target-for-novel-treatment-development
#20
Jan Willem Bruggeman, Jan Koster, Paul Lodder, Sjoerd Repping, Geert Hamer
Cancer cells have been found to frequently express genes that are normally restricted to the testis, often referred to as cancer/testis (CT) antigens or genes. Because germ cell-specific antigens are not recognized as "self" by the innate immune system, CT-genes have previously been suggested as ideal candidate targets for cancer therapy. The use of CT-genes in cancer therapy has thus far been unsuccessful, most likely because their identification has relied on gene expression in whole testis, including the testicular somatic cells, precluding the detection of true germ cell-specific genes...
June 15, 2018: Oncogene
keyword
keyword
24825
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"