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Rate of force development

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https://www.readbyqxmd.com/read/28429371/design-of-a-short-non-uniform-acquisition-protocol-for-quantitative-analysis-in-dynamic-cardiac-spect-imaging-a-retrospective-123-i-mibg-animal-study
#1
Yunlong Zan, Yong Long, Kewei Chen, Biao Li, Qiu Huang, Grant T Gullberg
PURPOSE: Our previous works have found that quantitative analysis of (123) I-MIBG kinetics in the heart with dynamic single-photon emission computed tomography (SPECT) offers the potential to quantify the innervation integrity at an early stage of left ventricular hypertrophy. However, conventional protocols involving a long acquisition time for dynamic imaging reduce the animal survival rate and thus make longitudinal analysis difficult. The goal of this work was to develop a procedure to reduce the total acquisition time by selecting non-uniform acquisition times for projection views while maintaining the accuracy and precision of estimated physiologic parameters...
April 21, 2017: Medical Physics
https://www.readbyqxmd.com/read/28428008/force-development-and-intracellular-ca-2-in-intact-cardiac-muscles-from-gravin-mutant-mice
#2
Zhitao Li, Sonal Singh, Santosh V Suryavanshi, Wengang Ding, Xiaoxu Shen, Cori S Wijaya, Wei Dong Gao, Bradley K McConnell
Gravin (AKAP12) is an A-kinase-anchoring-protein that scaffolds protein kinase A (PKA), β2-adrenergic receptor (β2-AR), protein phosphatase 2B and protein kinase C. Gravin facilitates β2-AR-dependent signal transduction through PKA to modulate cardiac excitation-contraction coupling and its removal positively affects cardiac contraction. Trabeculae from the right ventricles of gravin mutant (gravin-t/t) mice were employed for force determination. Simultaneously, corresponding intracellular Ca(2+) transient ([Ca(2+)]i) were measured...
April 17, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/28426514/comparison-of-the-hang-high-pull-and-loaded-jump-squat-for-the-development-of-vertical-jump-and-isometric-force-time-characteristics
#3
Dustin J Oranchuk, Tracey L Robinson, Zachary J Switaj, Eric J Drinkwater
Weightlifting movements have high skill demands and require expert coaching. Loaded jumps have a comparably lower skill demand, but may be similarly effective for improving explosive performance. The purpose of this study was to compare vertical jump performance, isometric force, and rate of force development (RFD) following a ten-week intervention employing the hang high-pull (hang-pull) or trap-bar jump squat (jump-squat). Eighteen NCAA Division II swimmers (8 males, 10 females) with at least one year of resistance training experience volunteered to participate...
April 15, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28420431/injuries-in-extreme-sports
#4
REVIEW
Lior Laver, Ioannis P Pengas, Omer Mei-Dan
Extreme sports (ES) are usually pursued in remote locations with little or no access to medical care with the athlete competing against oneself or the forces of nature. They involve high speed, height, real or perceived danger, a high level of physical exertion, spectacular stunts, and heightened risk element or death.Popularity for such sports has increased exponentially over the past two decades with dedicated TV channels, Internet sites, high-rating competitions, and high-profile sponsors drawing more participants...
April 18, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28419462/modeling-and-simulation-of-pivotal-clinical-trials-using-linked-models-for-multiple-endpoints-in-chronic-obstructive-pulmonary-disease-with-roflumilast
#5
Axel Facius, Andreas Krause, Laurent Claret, Rene Bruno, Gezim Lahu
Roflumilast is a selective phosphodiesterase 4 inhibitor (PDE4i) for the treatment of severe chronic obstructive pulmonary disease (COPD). In 2 large phase 3 trials in a broader population of COPD patients (BY217/M2-111, ClinicalTrials.gov: NCT00076089 and BY217/M2-112, ClinicalTrials.gov: NCT00430729), treatment with roflumilast reduced the rate of exacerbations; however, the reduction did not reach statistical significance. Two linked dose-response models for the primary (annualized COPD exacerbation counts) and secondary (change from baseline in forced expiratory volume in 1 second [FEV1 ]) end points were therefore developed to characterize and quantify effect sizes and the patient characteristics influencing them...
April 17, 2017: Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/28417093/instability-resistance-training-for-health-and-performance
#6
REVIEW
Erika Zemková
Recently, resistance exercises performed on an unstable surface have become part of athletic training and rehabilitation. Accordingly, their role in performance and health-oriented strength training has increasingly emerged as a matter of interest to researchers and conditioning specialists. A more pronounced activation of stabilizing muscles is assumed to be the main feature of instability resistance exercises. This assumption has been proven by EMG studies, which have highlighted significantly greater electromyographic activity of trunk-stabilizing muscles during exercises under unstable as compared to stable conditions...
April 2017: Journal of Traditional and Complementary Medicine
https://www.readbyqxmd.com/read/28414087/quantifying-the-potential-and-flux-landscapes-of-multi-locus-evolution
#7
Li Xu, Jin Wang
Exploration of multi-locus evolution is critically important for understanding evolutionary dynamics. Recombination and epistasis lead to complex evolutionary dynamics. Quantifying the stability and function of such multi-locus evolutionary systems globally is a long-standing challenge for evolutionary biologists. The conventional Wright, Fisher and quasi-linkage equilibrium (QLE) theories can only be applied to highly restricted, simplified and special evolutionary scenarios. In this study, we developed a non-equilibrium potential and flux landscape theory to explore the multi-locus evolution beyond Wright, Fisher and the QLE...
April 13, 2017: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/28411855/single-molecule-force-spectroscopy-for-in-situ-probing-oridonin-inhibited-ros-mediated-egf-egfr-interactions-in-living-kyse-150-cells
#8
Jiang Pi, Hua Jin, Jinhuan Jiang, Fen Yang, Huaihong Cai, Peihui Yang, Jiye Cai, Zheng W Chen
As the active anticancer component of Rabdosia Rubescens, oridonin has been proved to show strong anticancer activity in cancer cells, which is also found to be closely related to its specific inhibition effects on the EGFR tyrosine kinase activity. In this study, atomic force microscopy based single molecule force spectroscopy (AFM-SMFS) was used for real-time and in-situ detection of EGF-EGFR interactions in living esophageal cancer KYSE-150 cells to evaluate the anticancer activity of oridonin for the first time...
May 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28411340/attainment-and-retention-of-force-moderation-following-laparoscopic-resection-training-with-visual-force-feedback
#9
Rafael Hernandez, Arzu Onar-Thomas, Francesco Travascio, Shihab Asfour
BACKGROUND: Laparoscopic training with visual force feedback can lead to immediate improvements in force moderation. However, the long-term retention of this kind of learning and its potential decay are yet unclear. METHODS: A laparoscopic resection task and force sensing apparatus were designed to assess the benefits of visual force feedback training. Twenty-two male university students with no previous experience in laparoscopy underwent relevant FLS proficiency training...
April 14, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28410369/quantitative-assessment-of-the-impact-of-partially-protective-anti-schistosomiasis-vaccines
#10
Ramzi A Alsallaq, David Gurarie, Martial Ndeffo Mbah, Alison Galvani, Charles King
BACKGROUND: Mass drug administration (MDA) of praziquantel has been the intervention of choice against schistosomiasis but with limited success in interrupting the transmission. The development of anti-Schistosoma vaccines is underway. Our objective is to quantify the population-level impact of anti-Schistosoma vaccines when administered alone and in combination with mass drug administration (MDA) and determine factors in vaccine design and public health implementation that optimize vaccination role in schistosomiasis control and elimination...
April 14, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/28409351/inflammation-and-fibrosis-in-polycystic-kidney-disease
#11
Cheng Jack Song, Kurt A Zimmerman, Scott J Henke, Bradley K Yoder
Polycystic kidney disease (PKD) is a commonly inherited disorder characterized by cyst formation and fibrosis (Wilson, N Engl J Med 350:151-164, 2004) and is caused by mutations in cilia or cilia-related proteins, such as polycystin 1 or 2 (Oh and Katsanis, Development 139:443-448, 2012; Kotsis et al., Nephrol Dial Transplant 28:518-526, 2013). A major pathological feature of PKD is the development of interstitial inflammation and fibrosis with an associated accumulation of inflammatory cells (Grantham, N Engl J Med 359:1477-1485, 2008; Zeier et al...
2017: Results and Problems in Cell Differentiation
https://www.readbyqxmd.com/read/28403495/-diagnosis-and-therapeutic-management-in-kidney-ureter-and-bladder-trauma
#12
Karin Hirsch, Marco Heinz, Bernd Wullich
Trauma refers to the destruction of tissues or organs by external forces and it is the most common cause of mortality and morbidity in children (1, 2). Injuries of the genitourinary tract may be the result of blunt (falls, sport injuries, motor vehicle accidents and sexual abuse) or penetrating (stab wounds, gun shots, falling onto sharp objects) injuries. The genitourinary tract is significantly injured in 2.9% of paediatric trauma patients 4.In the paediatric population, the kidney is the most affected organ in the genitourinary tract (>60% of all genitourinary tract injuries) 4...
February 2017: Aktuelle Urologie
https://www.readbyqxmd.com/read/28403171/bacterial-biofilm-under-flow-first-a-physical-struggle-to-stay-then-a-matter-of-breathing
#13
Philippe Thomen, Jérôme Robert, Amaury Monmeyran, Anne-Florence Bitbol, Carine Douarche, Nelly Henry
Bacterial communities attached to surfaces under fluid flow represent a widespread lifestyle of the microbial world. Through shear stress generation and molecular transport regulation, hydrodynamics conveys effects that are very different by nature but strongly coupled. To decipher the influence of these levers on bacterial biofilms immersed in moving fluids, we quantitatively and simultaneously investigated physicochemical and biological properties of the biofilm. We designed a millifluidic setup allowing to control hydrodynamic conditions and to monitor biofilm development in real time using microscope imaging...
2017: PloS One
https://www.readbyqxmd.com/read/28401310/the-efficacy-of-periodised-resistance-training-on-neuromuscular-adaptation-in-older-adults
#14
Jenny A Conlon, Robert U Newton, James J Tufano, Luis E Peñailillo, Harry G Banyard, Amanda J Hopper, Ashley J Ridge, G Gregory Haff
PURPOSE: This study compared the effect of periodised versus non-periodised (NP) resistance training on neuromuscular adaptions in older adults. METHODS: Forty-one apparently healthy untrained older adults (female = 21, male = 20; 70.9 ± 5.1 years; 166.3 ± 8.2 cm; 72.9 ± 13.4 kg) were recruited and randomly stratified to an NP, block periodised (BP), or daily undulating periodised (DUP) training group. Outcome measures were assessed at baseline and following a 22-week resistance training intervention (3 day week(-1)), including: muscle cross-sectional area (CSA), vertical jump performance, isometric and isokinetic peak torque, isometric rate of force development (RFD), and muscle activation...
April 11, 2017: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/28399854/improved-n-butanol-production-via-co-expression-of-membrane-targeted-tilapia-metallothionein-and-the-clostridial-metabolic-pathway-in-escherichia-coli
#15
Wei-Chih Chin, Kuo-Hsing Lin, Chun-Chi Liu, Kenji Tsuge, Chieh-Chen Huang
BACKGROUND: N-Butanol has favorable characteristics for use as either an alternative fuel or platform chemical. Bio-based n-butanol production using microbes is an emerging technology that requires further development. Although bio-industrial microbes such as Escherichia coli have been engineered to produce n-butanol, reactive oxygen species (ROS)-mediated toxicity may limit productivity. Previously, we show that outer-membrane-targeted tilapia metallothionein (OmpC-TMT) is more effective as an ROS scavenger than human and mouse metallothioneins to reduce oxidative stress in the host cell...
April 11, 2017: BMC Biotechnology
https://www.readbyqxmd.com/read/28395091/morbidity-among-the-israeli-defense-force-response-team-during-nepal-post-earthquake-mission-2015
#16
Tamar Lachish, Aviad Bar, Heli Alalouf, Ofer Merin, Eli Schwartz
Background: On 25 April 2015, a 7.8-magnitude earthquake struck Nepal. Soon after, the Israel Defense Force (IDF) dispatched a rapid-response team and opened a tertiary field hospital in Kathmandu. There is limited data regarding the spectrum of diseases among rescue teams to disease-stricken areas. The aim of this study was to assess the morbidity among the field-hospital staff during the mission. Methods: The rescue team was deployed for a 2-week mission in Kathmandu...
March 1, 2017: Journal of Travel Medicine
https://www.readbyqxmd.com/read/28394833/optimizing-half-squat-post-activation-potential-load-in-squat-jump-training-for-eliciting-relative-maximal-power-in-ski-jumpers
#17
A Gołaś, M Wilk, P Statsny, A Maszczyk, K Pajerska, A Zajac
Training load manipulation in a single workout session can increase or decrease training effectiveness in terms of athlete's strength or power gains. In ski jumping the complex training that elicits maximal power gains may take advantage of the post activation potentiation mechanism (PAP). The aim of research was to evaluate the changes in rate of force development (RFD), rate of power development (RPD) and jump height during a complex training session consisted of the barbell half squat (Sq) as an conditioning exercise with loads ranged between 60-100% of 1 repetition maximum (1RM), followed by a body weight squat jump (SqJ) as a performance task...
April 7, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28392437/a-model-of-cardiac-contraction-based-on-novel-measurements-of-tension-development-in-human-cardiomyocytes
#18
Sander Land, So-Jin Holohan, Nicolas P Smith, Cristobal G Dos Remedios, Jonathan C Kentish, Steven A Niederer
Experimental data from human cardiac myocytes at body temperature is crucial for a quantitative understanding of clinically relevant cardiac function and development of whole-organ computational models. However, such experimental data is currently very limited. Specifically, important measurements to characterize changes in tension development in human cardiomyocytes that occur with perturbations in cell length are not available. To address this deficiency, in this study we present an experimental data set collected from skinned human cardiac myocytes, including the passive and viscoelastic properties of isolated myocytes, the steady-state force calcium relationship at different sarcomere lengths, and changes in tension following a rapid increase or decrease in length, and after constant velocity shortening...
April 6, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28391828/low-voltage-electrochemically-stimulated-stir-membrane-liquid-liquid-microextraction-as-a-novel-technique-for-the-determination-of-methadone
#19
Katayoun Mahdavi Ara, Farhad Raofie
In the present work, for the first time, a new portable setup was designed, developed and presented for the extraction of methadone, as a basic drug model from biological fluid samples using a low-voltage electrically stimulated stir membrane liquid-liquid microextraction technique (LV-ESSM-LLME), followed by high-performance liquid chromatography with ultraviolet detection. This new approach combines the advantages of stir membrane liquid-liquid microextraction and electrokinetic migration in the same unit under soft electrochemical conditions in a portable device, allowing for the isolation and preconcentration of the target analyte in a simple and efficient manner under three-phase mode...
June 1, 2017: Talanta
https://www.readbyqxmd.com/read/28390697/smoking-prevalence-and-attributable-disease-burden-in-195-countries-and-territories-1990-2015-a-systematic-analysis-from-the-global-burden-of-disease-study-2015
#20
(no author information available yet)
BACKGROUND: The scale-up of tobacco control, especially after the adoption of the Framework Convention for Tobacco Control, is a major public health success story. Nonetheless, smoking remains a leading risk for early death and disability worldwide, and therefore continues to require sustained political commitment. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) offers a robust platform through which global, regional, and national progress toward achieving smoking-related targets can be assessed...
April 5, 2017: Lancet
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