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https://www.readbyqxmd.com/read/27913147/electro-kinetically-driven-peristaltic-transport-of-viscoelastic-physiological-fluids-through-a-finite-length-capillary-mathematical-modelling
#1
Dharmendra Tripathi, Ashu Yadav, O Anwar Bég
Analytical solutions are developed for the electro-kinetic flow of a viscoelastic biological liquid in a finite length cylindrical capillary geometry under peristaltic waves. The Jefferys' non-Newtonian constitutive model is employed to characterize rheological properties of the fluid. The unsteady conservation equations for mass and momentum with electro-kinetic and Darcian porous medium drag force terms are reduced to a system of steady linearized conservation equations in an axisymmetric coordinate system...
November 29, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27912990/cancer-rehabilitation-an-overview-of-current-need-delivery-models-and-levels-of-care
#2
REVIEW
Andrea L Cheville, Karen Mustian, Kerri Winters-Stone, David S Zucker, Gail L Gamble, Catherine M Alfano
The relevance of cancer rehabilitation as a public health issue grows steadily as cancer incidence, survival, and mean patient age increase. Reported rates of physical impairment and disability are already high, prior to the anticipated influx of aged cancer survivors. Despite the high prevalence of cancer-related disablement, treatment rates, even for readily remediable physical impairments, are as low as 1-2%. In addition to low referral rates, a challenge to patient-centric cancer rehabilitation is a fractured system that requires multiple visits to a range of specialists to address even a single issue, and cancer survivors generally have several...
February 2017: Physical Medicine and Rehabilitation Clinics of North America
https://www.readbyqxmd.com/read/27910941/rapid-mapping-of-polarization-switching-through-complete-information-acquisition
#3
Suhas Somnath, Alex Belianinov, Sergei V Kalinin, Stephen Jesse
Polarization switching in ferroelectric and multiferroic materials underpins a broad range of current and emergent applications, ranging from random access memories to field-effect transistors, and tunnelling devices. Switching in these materials is exquisitely sensitive to local defects and microstructure on the nanometre scale, necessitating spatially resolved high-resolution studies of these phenomena. Classical piezoresponse force microscopy and spectroscopy, although providing necessary spatial resolution, are fundamentally limited in data acquisition rates and energy resolution...
December 2, 2016: Nature Communications
https://www.readbyqxmd.com/read/27909885/kinematics-and-muscle-activation-patterns-during-a-maximal-voluntary-rate-activity-in-healthy-elderly-and-young-adults
#4
Eva Chadnova, Nancy St-Onge, Richard Courtemanche, Robert D Kilgour
BACKGROUND: Maximal voluntary rate (MVR) performance tasks can provide important age-related information to the limiting factors associated with movement and the development of fatigue. AIM: To determine whether kinematic and muscle activation patterns during an MVR task differ between young and older adults. METHODS: We continuously measured frequency, amplitude, peak velocity, index of co-contraction and median frequencies of the index finger flexors and extensors during a 20-s MVR task in 10 young and 10 older subjects...
December 1, 2016: Aging Clinical and Experimental Research
https://www.readbyqxmd.com/read/27909224/sarcomeric-protein-modification-during-adrenergic-stress-enhances-cross-bridge-kinetics-and-cardiac-output
#5
Kenneth S Gresham, Ranganath Mamidi, Jiayang Li, Hyerin Kwak, Julian E Stelzer
Molecular adaptations to chronic neurohormonal stress, including sarcomeric protein cleavage and phosphorylation, provide a mechanism to increase ventricular contractility and enhance cardiac output, yet the link between sarcomeric protein modifications and changes in myocardial function remains unclear. To examine the effects of neurohormonal stress on post-translational modifications of sarcomeric proteins, mice were administered combined α- and β-adrenergic receptor agonists (isoproterenol and phenylephrine; IPE) for 14 days using implantable osmotic pumps...
December 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27909035/randomised-controlled-pilot-study-to-investigate-the-effectiveness-of-thoracic-epidural-and-paravertebral-blockade-in-reducing-chronic-post-thoracotomy-pain-topic-feasibility-study-protocol
#6
Joyce Yeung, Teresa Melody, Amy Kerr, Babu Naidu, Lee Middleton, Kostas Tryposkiadis, Jane Daniels, Fang Gao
INTRODUCTION: Open chest surgery (thoracotomy) is considered the most painful of surgical procedures. Forceful wound retraction, costochondral dislocation, posterior costovertebral ligament disruption, intercostal nerve trauma and wound movement during respiration combine to produce an acute, severe postoperative pain insult and persistent chronic pain many months after surgery is common. Three recent systematic reviews conclude that unilateral continuous paravertebral blockade (PVB) provides analgesia at least equivalent to thoracic epidural blockade (TEB) in the postoperative period, has a lower failure rate, and symptom relief that lasted months...
December 1, 2016: BMJ Open
https://www.readbyqxmd.com/read/27906033/the-role-of-the-backbone-torsion-in-protein-folding
#7
EDITORIAL
Irina Sorokina, Arcady Mushegian
BACKGROUND: The set of forces and sequence of events that govern the transition from an unfolded polypeptide chain to a functional protein with correct spatial structure remain incompletely known, despite the importance of the problem and decades of theory development, computer simulations, and laboratory experiments. Information about the correctly folded state of most proteins is likely to be present in their sequences, and yet many proteins fail to attain native structure after overexpression in a non-native environment or upon experimental denaturation and refolding...
December 1, 2016: Biology Direct
https://www.readbyqxmd.com/read/27900640/statistical-effects-of-religious-participation-and-marriage-on-substance-use-and-abuse-in-racial-and-ethnic-minorities
#8
Kristine Ria Hearld, Amy Badham, Henna Budhwani
Substance use and abuse, which includes alcohol use, alcohol dependence, drug use, and drug dependence, inflicts a substantial toll on Americans. Although studies have demonstrated the protective effect of social support, such as religious participation and via marriage, understanding their influence on racial and ethnic minorities is limited. Thus, the aim of this study is to assess the impact of social support on substance use and abuse in racial and ethnic minorities. The Collaborative Psychiatric Epidemiology Surveys, sponsored by the National Institute of Mental Health, a repository of race, ethnicity, and mental health data, was leveraged to develop four models using multivariate analysis, specifically logistic regression to estimate the probability of meeting the criteria for substance use and abuse...
November 29, 2016: Journal of Religion and Health
https://www.readbyqxmd.com/read/27900419/measurement-of-giardia-lamblia-adhesion-force-using-an-integrated-microfluidic-assay
#9
Ling Lu, Guo-Xia Zheng, Yu-Suo Yang, Cheng-Yu Feng, Fang-Fang Liu, Yun-Hua Wang
The mechanisms how Giardias attach to the intestinal epithelium remain unclear. None of the methods currently being used to measure the attachment force could provide a continuous nutrition supply and a micro-aerobic atmosphere to the Giardia. Besides, they are all labor-intensive. In the present research, a microfluidic method based on electric circuit analogy was developed. The input fluid flowed through the inlet channel with different lengths and was distributed in four assay chambers. Shear force gradients were generated in chambers, too...
November 30, 2016: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/27895473/calf-raise-senior-a-new-test-for-assessment-of-plantar-flexor-muscle-strength-in-older-adults-protocol-validity-and-reliability
#10
Helô-Isa André, Filomena Carnide, Edgar Borja, Fátima Ramalho, Rita Santos-Rocha, António P Veloso
PURPOSE: This study aimed to develop a new field test protocol with a standardized measurement of strength and power in plantar flexor muscles targeted to functionally independent older adults, the calf-raise senior (CRS) test, and also evaluate its reliability and validity. PATIENTS AND METHODS: Forty-one subjects aged 65 years and older of both sexes participated in five different cross-sectional studies: 1) pilot (n=12); 2) inter- and intrarater agreement (n=12); 3) construct (n=41); 4) criterion validity (n=33); and 5) test-retest reliability (n=41)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27890575/3d-hybrid-modelling-of-vascular-network-formation
#11
Holger Perfahl, Barry D Hughes, Tomás Alarcón, Philip K Maini, Mark C Lloyd, Matthias Reuss, Helen M Byrne
We develop an off-lattice, agent-based model to describe vasculogenesis, the de novo formation of blood vessels from endothelial progenitor cells during development. The endothelial cells that comprise our vessel network are viewed as linearly elastic spheres that move in response to the forces they experience. We distinguish two types of endothelial cells: vessel elements are contained within the network and tip cells are located at the ends of vessels. Tip cells move in response to mechanical forces caused by interactions with neighbouring vessel elements and the local tissue environment, chemotactic forces and a persistence force which accounts for their tendency to continue moving in the same direction...
November 24, 2016: Journal of Theoretical Biology
https://www.readbyqxmd.com/read/27890390/world-association-of-sleep-medicine-wasm-2016-standards-for-recording-and-scoring-leg-movements-in-polysomnograms-developed-by-a-joint-task-force-from-the-international-and-the-european-restless-legs-syndrome-study-groups-irlssg-and-eurlssg
#12
R Ferri, S Fulda, R P Allen, M Zucconi, O Bruni, S Chokroverty, L Ferini-Strambi, B Frauscher, D Garcia-Borreguero, M Hirshkowitz, B Högl, Y Inoue, A Jahangir, M Manconi, C L Marcus, D L Picchietti, G Plazzi, J W Winkelman, R S Zak
This report presents the results of the work by a joint task force of the International and European Restless Legs Syndrome Study Groups and World Association of Sleep Medicine that revised and updated the current standards for recording and scoring leg movements (LM) in polysomnographic recordings (PSG). First, the background of the decisions made and the explanations of the new rules are reported and then specific standard rules are presented for recording, detecting, scoring and reporting LM activity in PSG...
November 7, 2016: Sleep Medicine
https://www.readbyqxmd.com/read/27878373/restrictive-allograft-syndrome-after-lung-transplantation-new-radiological-insights
#13
Adriana Dubbeldam, Caroline Barthels, Johan Coolen, Johny A Verschakelen, Stijn E Verleden, Robin Vos, Geert M Verleden, Walter De Wever
OBJECTIVES: To describe the CT changes in patients with restrictive allograft syndrome (RAS) after lung transplantation, before and after clinical diagnosis. METHODS: This retrospective study included 22 patients with clinical diagnosis of RAS. Diagnosis was based on a combination of forced expiratory volume (FEV1) decline (≥20 %) and total lung capacity (TLC) decline (≥10 %). All available CT scans after transplantation were analyzed for the appearance and evolution of lung abnormalities...
November 22, 2016: European Radiology
https://www.readbyqxmd.com/read/27871502/screening-for-abdominal-aortic-aneurysm-in-asymptomatic-adults
#14
REVIEW
Muhammad Usman Ali, Donna Fitzpatrick-Lewis, John Miller, Rachel Warren, Meghan Kenny, Diana Sherifali, Parminder Raina
BACKGROUND: This report was produced for the Canadian Task Force on Preventive Health Care to provide guidelines on screening for abdominal aortic aneurysm (AAA) with ultrasound scan. PURPOSE: The aim of this systematic review is to examine the evidence on benefits and harms of AAA screening. SEARCH STRATEGY: This systematic review considered studies from the most recent United States Preventive Services Task Force review on AAA screening and passed through the screening process with citations identified in our search up to April 2015 (PROSPERO Registration #CRD42015019047)...
December 2016: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/27871252/age-patterns-and-transmission-characteristics-of-hand-foot-and-mouth-disease-in-china
#15
Jijun Zhao, Fachun Jiang, Lianfa Zhong, Jianping Sun, Junhang Ding
BACKGROUND: Hand, foot and mouth disease (HFMD) has circulated in China and caused yearly outbreak. To understand the transmission of the disease and to assess the spatial variation in cases reported, we examined age-specific transmission characteristics and reporting rates of HFMD for 31 provinces in mainland China. METHODS: We first analyzed incidence spatial patterns and age-specific incidence patterns using dataset from 2008 to 2012. Transmission characteristics were estimated based on catalytic model...
November 21, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27869319/the-ca-2-sensitizer-ck-2066260-increases-myofibrillar-ca-2-sensitivity-and-submaximal-force-selectively-in-fast-skeletal-muscle
#16
Darren T Hwee, Arthur J Cheng, James J Hartman, Aaron C Hinken, Ken Lee, Nickie Durham, Alan J Russell, Fady I Malik, Håkan Westerblad, Jeffrey R Jasper
Skeletal muscle dysfunction occurs in many diseases and can lead to muscle weakness and premature muscle fatigue. Here we show that the fast skeletal troponin activator, CK-2066260, counteracts muscle weakness by increasing troponin Ca(2+) affinity, thereby increasing myofibrillar Ca(2+) sensitivity. Exposure to CK-2066260 resulted in a concentration-dependent increase in the Ca(2+) sensitivity of ATPase activity in isolated myofibrils and reconstituted hybrid sarcomeres containing fast skeletal muscle troponin C...
November 21, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27867817/evaluating-the-enhancement-and-improvement-of-china-s-technology-and-financial-services-platform-innovation-strategy
#17
Ching-Sung Wu, Kuang-Hua Hu, Fu-Hsiang Chen
The development of high-tech industry has been prosperous around the world in past decades, while technology and finance have already become the most significant issues in the information era. While high-tech firms are a major force behind a country's economic development, it requires a lot of money for the development process, as well as the financing difficulties for its potential problems, thus, how to evaluate and establish appropriate technology and financial services platforms innovation strategy has become one of the most critical and difficult issues...
2016: SpringerPlus
https://www.readbyqxmd.com/read/27866053/lc-esi-ms-ms-evaluation-of-forced-degradation-behaviour-of-silodosin-in-vitro-anti-cancer-activity-evaluation-of-silodosin-and-major-degradation-products
#18
Chiguru Vishnuvardhan, Baikadi Saibaba, Lingesh Allakonda, Debasish Swain, S Gananadhamu, R Srinivas, N Satheeshkumar
Silodosin (SLD) a novel α1-adrenoceptor antagonist was subjected to forced degradation involving hydrolysis (acidic, alkaline and neutral), oxidative, photolysis and thermal stress, as per ICH specified conditions. The drug underwent significant degradation under hydrolytic (acidic, alkaline and neutral) and oxidative stress conditions whereas, it was found to be stable under other stress conditions. A rapid, precise, accurate and robust chromatographic method for the separation of the drug and its degradation products (DPs) was developed on a Fortis C18 analytical column (150×4...
November 10, 2016: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/27865773/particulate-suspension-effect-on-peristaltically-induced-unsteady-pulsatile-flow-in-a-narrow-artery-blood-flow-model
#19
Sara I Abdelsalam, Kambiz Vafai
This work is concerned with theoretically investigating the pulsatile flow of a fluid with suspended particles in a flow driven by peristaltic waves that deform the wall of a small blood artery in the shape of traveling sinusoidal waves with constant velocity. The problem formulation in the wave frame of reference is presented and the governing equations are developed up to the second-order in terms of the asymptotic expansion of Womersley number which characterizes the unsteady effect in the wave frame. We suppose that the flow rate imposed, in this frame, is a function versus time...
November 16, 2016: Mathematical Biosciences
https://www.readbyqxmd.com/read/27864602/beyond-bread-and-beer-whole-cell-protein-extracts-from-baker-s-yeast-as-a-bulk-source-for-3d-cell-culture-matrices
#20
Nicholas Bodenberger, Dennis Kubiczek, Patrick Paul, Nico Preising, Lukas Weber, Ramona Bosch, Rudolf Hausmann, Kay-Eberhard Gottschalk, Frank Rosenau
Here, we present a novel approach to form hydrogels from yeast whole cell protein. Countless hydrogels are available for sophisticated research, but their fabrication is often difficult to reproduce, with the gels being complicated to handle or simply too expensive. The yeast hydrogels presented here are polymerized using a four-armed, amine reactive crosslinker and show a high chemical and thermal resistance. The free water content was determined by measuring swelling ratios for different protein concentrations, and in a freeze-drying approach, pore sizes of up to 100 μm in the gel could be created without destabilizing the 3D network...
November 18, 2016: Applied Microbiology and Biotechnology
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