keyword
MENU ▼
Read by QxMD icon Read
search

Rate of force development

keyword
https://www.readbyqxmd.com/read/28821484/measurement-and-mathematical-characterization-of-cell-level-pharmacokinetics-of-antibody-drug-conjugates-a-case-study-with-trastuzumab-vc-mmae
#1
Aman P Singh, Dhaval K Shah
The main objective of this work was to understand and mathematically characterize the cellular disposition of a tool ADC, trastuzumab-vc-MMAE (T-vc-MMAE). Towards this goal, three different analytical methods were developed to measure the concentrations of different ADC related analytes in the media and cell lysate. An LC-MS/MS method was developed to quantify unconjugated drug (i.e. MMAE) concentrations, a forced deconjugation method was developed to quantify total drug concentrations, and an ELISA method was developed to quantify total antibody (i...
August 18, 2017: Drug Metabolism and Disposition: the Biological Fate of Chemicals
https://www.readbyqxmd.com/read/28818313/controlled-single-cell-cyclic-compression-and-transcription-analysis-a-pilot-study
#2
Paola Gavazzo, Loredana Petecchia, Paolo Facci, Massimo Vassalli, Federica Viti
An innovative platform for the study of the molecular mechanisms at the basis of mechanotransduction has been implemented, developing an experimental approach capable of providing controlled dynamic compression stimuli and retrieving the biomolecular response with single-cell sensitivity. The system provides the ability to perform compression-release cycles on single cells with controlled forces in the nN range and a user-defined repetition rate. Experimental procedures to perform qPCR from a small set of single cells were finely tuned...
August 12, 2017: Biophysical Chemistry
https://www.readbyqxmd.com/read/28813931/making-neurorehabilitation-fun-multiplayer-training-via-damping-forces-balancing-differences-in-skill-levels
#3
Kilian Baur, Peter Wolf, Robert Riener, Jaime E Duarte
Multiplayer environments are thought to increase the training intensity in robot-aided rehabilitation therapy after stroke. We developed a haptic-based environment to investigate the dynamics of two-player training performing time-constrained reaching movements using the ARMin rehabilitation robot. We implemented a challenge level adaptation algorithm that controlled a virtual damping coefficient to reach a desired success rate. We tested the algorithm's effectiveness in regulating the success rate during game play in a simulation with computer-controlled players, in a feasibility study with six unimpaired players, and in a single session with one stroke patient...
July 2017: IEEE ... International Conference on Rehabilitation Robotics: [proceedings]
https://www.readbyqxmd.com/read/28811312/myosin-ii-is-not-required-for-drosophila-tracheal-branch-elongation-and-cell-intercalation
#4
Amanda Ochoa-Espinosa, Stefan Harmansa, Emmanuel Caussinus, Markus Affolter
The Drosophila tracheal system consists of an interconnected network of monolayered epithelial tubes that ensures oxygen transport in the larval and adult body. During tracheal dorsal branch (DB) development, individual DBs elongate as a cluster of cells, led by tip cells at the front and trailing cells in the rear. Branch elongation is accompanied by extensive cell intercalation and cell lengthening of the trailing stalk cells. Although cell intercalation is governed by Myosin II (MyoII)-dependent forces during tissue elongation in the Drosophila embryo that lead to germ-band extension, it remained unclear whether MyoII plays a similar active role during tracheal branch elongation and intercalation...
August 15, 2017: Development
https://www.readbyqxmd.com/read/28811019/introducing-a-new-and-rapid-microextraction-approach-based-on-magnetic-ionic-liquids-stir-bar-dispersive-liquid-microextraction
#5
Alberto Chisvert, Juan L Benedé, Jared L Anderson, Stephen A Pierson, Amparo Salvador
With the aim of contributing to the development and improvement of microextraction techniques, a novel approach combining the principles and advantages of stir bar sorptive extraction (SBSE) and dispersive liquid-liquid microextraction (DLLME) is presented. This new approach, termed stir bar dispersive liquid microextraction (SBDLME), involves the addition of a magnetic ionic liquid (MIL) and a neodymium-core magnetic stir bar into the sample allowing the MIL coat the stir bar due to physical forces (i.e., magnetism)...
August 29, 2017: Analytica Chimica Acta
https://www.readbyqxmd.com/read/28810982/evaluation-of-the-validity-and-response-burden-of-patient-self-report-measures-of-the-pain-assessment-screening-tool-and-outcomes-registry-pastor
#6
Karon F Cook, Michael A Kallen, Chester Buckenmaier, Diane M Flynn, Steven R Hanling, Teresa S Collins, Kristin Joltes, Kyung Kwon, Sheila Medina-Torne, Parisa Nahavandi, Joshua Suen, Richard Gershon
BACKGROUND: In 2009, the Army Pain Management Task Force was chartered. On the basis of their findings, the Department of Defense recommended a comprehensive pain management strategy that included development of a standardized pain assessment system that would collect patient-reported outcomes data to inform the patient-provider clinical encounter. The result was the Pain Assessment Screening Tool and Outcomes Registry (PASTOR). The purpose of this study was to assess the validity and response burden of the patient-reported outcome measures in PASTOR...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810980/risk-factors-for-rhabdomyolysis-in-the-u-s-army
#7
Owen T Hill, Dennis E Scofield, Jenna Usedom, Lakmini Bulathsinhala, Craig McKinnon, Paul Kwon, Timothy Haley, Robert Carter
The standardized mortality rate of rhabdomyolysis (RM) in Active Duty U.S. Army Soldiers is considerably higher than in the civilian population. RM occurs when large amounts of intracellular contents from damaged skeletal muscle escape into circulation, leading to serious sequelae (e.g., acute renal failure, hyperkalemia, compartment syndrome). Extended physical exertion, especially in hot environments, and trauma can precipitate RM. The aim of this study was to identify RM risk factors among U.S. Active Duty Army (ADA) Soldiers...
July 2017: Military Medicine
https://www.readbyqxmd.com/read/28810793/image-method-for-electrostatic-energy-of-polarizable-dipolar-spheres
#8
Kyle S Gustafson, Guoxi Xu, Karl F Freed, Jian Qin
The multiple-scattering theory for the electrostatics of many-body systems of monopolar spherical particles, embedded in a dielectric medium, is generalized to describe the electrostatics of these particles with embedded dipoles and multipoles. The Neumann image line construction for the electrostatic polarization produced by one particle is generalized to compute the energy, forces, and torques for the many-body system as functions of the positions of the particles. The approach is validated by comparison with direct numerical calculation, and the convergence rate is analyzed and expressed in terms of the discontinuity in dielectric contrast and particle density...
August 14, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/28803815/patient-specific-contact-stress-does-not-predict-polyethylene-wear-rate-in-a-specific-pressfit-cup
#9
Georg Matziolis, Linda Krakow, Frank Layher, Klaus Sander, Joerg Bossert, Steffen Brodt
BACKGROUND: The most common reason for revision total hip arthroplasty remains polyethylene wear. Development dysplasia of the hip and revision situations requires a conscious compromise of implant position. The surgeon should know about the consequence on wear via a possible change in hip contact force. The objective of this study is to investigate whether annual wear is dependent on hip contact force. METHODS: Forty-five inserts (DuraLoc, DePuy) that were explanted in our department were included...
July 25, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28803215/structural-tribological-and-mechanical-properties-of-the-hind-leg-joint-of-a-jumping-insect-using-katydids-to-inform-bioinspired-lubrication-systems
#10
Jun Kyun Oh, Spencer T Behmer, Richelle Marquess, Cengiz Yegin, Ethan A Scholar, Mustafa Akbulut
This study investigates the structural properties of the hind leg femur-tibia joint in adult katydids (Orthoptera: Tettigoniidae), including its tribological and mechanical properties. It is of particular interest because the orthopteran (e.g., grasshoppers, crickets, and katydids) hind leg is highly specialized for jumping. We show that the katydid hind leg femur-tibia joint had unique surfaces and textures, with a friction coefficient (μ) at its coupling surface of 0.053 ± 0.001. Importantly, the sheared surfaces at this joint showed no sign of wear or damage, even though it had undergone thousands of external shearing cycles...
August 9, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28800103/the-ultrasonic-directional-tidal-breathing-pattern-sensor-equitable-design-realization-based-on-phase-information
#11
Arijit Sinharay, Raj Rakshit, Anwesha Khasnobish, Tapas Chakravarty, Deb Ghosh, Arpan Pal
Pulmonary ailments are conventionally diagnosed by spirometry. The complex forceful breathing maneuver as well as the extreme cost of spirometry renders it unsuitable in many situations. This work is aimed to facilitate an emerging direction of tidal breathing-based pulmonary evaluation by designing a novel, equitable, precise and portable device for acquisition and analysis of directional tidal breathing patterns, in real time. The proposed system primarily uses an in-house designed blow pipe, 40-kHz air-coupled ultrasound transreceivers, and a radio frequency (RF) phase-gain integrated circuit (IC)...
August 11, 2017: Sensors
https://www.readbyqxmd.com/read/28800005/the-effects-of-british-army-footwear-on-ground-reaction-force-and-temporal-parameters-of-british-army-foot-drill
#12
Alex J Rawcliffe, Scott M Graham, Richard J Simpson, Gavin L Moir, Russell Jj Martindale, Stelios G Psycharakis, Chris Connaboy
High rates of occupational training-related lower-limb musculoskeletal [MSK] overuse injuries are reported for British Army recruits during basic training. Foot-drill is a repetitive impact loading occupational activity and involves striking the ground violently with an extended-knee [straight-leg] landing. Foot-drill produces vertical ground reaction forces [vGRF] equal to and/or greater than those reported for high-level plyometric exercises/activities. Shock absorbing footwear aid in the attenuation of the magnitude of vGRF, resulting in a reduced risk of lower-limb MSK overuse injury when running...
August 9, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28797476/temperature-effects-on-aerobic-scope-and-cardiac-performance-of-european-perch-perca-fluviatilis
#13
Denise Lyager Jensen, Johannes Overgaard, Tobias Wang, Hans Gesser, Hans Malte
Several recent studies have highlighted how impaired cardiac performance at high temperatures and in hypoxia may compromise the capacity for oxygen transport. Thus, at high temperatures impaired cardiac capacity is proposed to reduce oxygen transport to a degree that lowers aerobic scope and compromises thermal tolerance (the oxygen- and capacity-limited thermal tolerance (OCLTT) hypothesis). To investigate this hypothesis, we measured aerobic and cardiac performance of a eurythermal freshwater teleost, the European perch (Perca fluviatilis)...
August 2017: Journal of Thermal Biology
https://www.readbyqxmd.com/read/28795733/time-resolved-nanomechanics-of-a-single-cell-under-the-depolymerization-of-the-cytoskeleton
#14
Pablo D Garcia, Carlos R Guerrero, Ricardo Garcia
Single cell stiffness measurements consider cells as passive and elastic materials which react instantaneously to an external force. This approximation is at odds with the complex structure of the cell which includes solid and liquid components. Here we develop a force microscopy method to measure the time and frequency dependencies of the elastic modulus, the viscosity coefficient, the loss modulus and the relaxation time of a single live cell. These parameters have different time and frequency dependencies...
August 10, 2017: Nanoscale
https://www.readbyqxmd.com/read/28790201/division-of-labor-bet-hedging-and-the-evolution-of-mixed-biofilm-investment-strategies
#15
Nick Vallespir Lowery, Luke McNally, William C Ratcliff, Sam P Brown
Bacterial cells, like many other organisms, face a tradeoff between longevity and fecundity. Planktonic cells are fast growing and fragile, while biofilm cells are often slower growing but stress resistant. Here we ask why bacterial lineages invest simultaneously in both fast- and slow-growing types. We develop a population dynamic model of lineage expansion across a patchy environment and find that mixed investment is favored across a broad range of environmental conditions, even when transmission is entirely via biofilm cells...
August 8, 2017: MBio
https://www.readbyqxmd.com/read/28789699/oral-pyridoxine-can-substitute-for-intravenous-pyridoxine-in-managing-patients-with-severe-poisoning-with-isoniazid-and-rifampicin-fixed-dose-combination-tablets-a-case-report
#16
M D S A Dilrukshi, C A P Ratnayake, C A Gnanathasan
BACKGROUND: Fixed drug combination of isoniazid and rifampicin is a rare cause of poisoning even in endemic countries for tuberculosis infection. Severe poisoning can cause severe morbidity and mortality if not treated promptly. Though intravenous pyridoxine is the preferred antidote for severe standard isoniazid poisoning it is not freely available even in best of care centers. We describe a case of severe poisoning with fixed drug combination of isoniazid and rifampicin successfully managed with oral pyridoxine at national hospital of Sri Lanka...
August 8, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/28777249/isometric-mid-thigh-pull-performance-is-associated-with-athletic-performance-and-sprinting-kinetics-in-division-i-men-and-women-s-basketball-players
#17
Jeremy R Townsend, David Bender, William Vantrease, John Hudy, Kevin Huet, Cassie Williamson, Emily Bechke, Paul Serafini, Gerald T Mangine
PURPOSE: To examine the relationships between isometric mid-thigh pull (IMTP) force, athletic performance measures, and sprint kinetics in Division I men's and women's basketball players. METHODS: Twenty-three (male = 8, female = 15) division 1 basketball players completed a maximal 20-m sprint trial while tethered to a device which provided kinetic feedback (peak and average sprinting power, velocity and force). Additionally, one repetition-maximal (1RM) front squat, 1RM hang clean, vertical jump height, and agility (pro-agility and lane agility) tests were performed...
July 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28777246/the-effects-of-jaw-clenching-and-jaw-alignment-mouthpiece-use-on-force-production-during-vertical-jump-and-isometric-clean-pull
#18
Charles R Allen, Yang-Chieh Fu, Vanessa Cazas-Moreno, Melinda W Valliant, Jacob R Gdovin, Charles C Williams, John C Garner
This study examined the effects of jaw clenching, and a self-adapted, jaw repositioning mouthpiece on force production during maximum countermovement vertical jump and maximum isometric mid-thigh clean pull assessments in an attempt to determine any ergogenic effects attributable to clenching, jaw repositioning mouthpiece use, or the combination of both. Thirty-six male subjects performed vertical jump and isometric clean pull assessments from a force platform under various mouthpiece and clench conditions...
July 31, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28774942/on-farm-euthanasia-practices-and-attitudes-of-commercial-meat-rabbit-producers
#19
Jessica Walsh, Aaron Percival, Brian Tapscott, Patricia V Turner
Appropriate and timely on-farm euthanasia is the responsibility of the producer, working together with their herd veterinarian. Unfortunately, validated methods for euthanasia of commercial meat rabbits are lacking and there are few educational materials available for producer training. Because euthanasia must be performed in a timely fashion to minimise suffering, it is critical to ensure that methods used are aesthetic, humane and effective. We surveyed Canadian meat rabbit producers for current on-farm euthanasia practices as well as attitudes towards the methods they employed and thoughts on novel euthanasia techniques...
August 3, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28773810/thermo-mechanical-characterization-of-friction-stir-spot-welded-aa7050-sheets-by-means-of-experimental-and-fem-analyses
#20
Gianluca D'Urso, Claudio Giardini
The present study was carried out to evaluate how the friction stir spot welding (FSSW) process parameters affect the temperature distribution in the welding region, the welding forces and the mechanical properties of the joints. The experimental study was performed by means of a CNC machine tool obtaining FSSW lap joints on AA7050 aluminum alloy plates. Three thermocouples were inserted into the samples to measure the temperatures at different distance from the joint axis during the whole FSSW process. Experiments was repeated varying the process parameters, namely rotational speed, axial feed rate and plunging depth...
August 11, 2016: Materials
keyword
keyword
24821
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"