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Rate of force development

Laura Ellwein Fix, Joseph Khoury, Russell R Moores, Lauren Linkous, Matthew Brandes, Henry J Rozycki
Non-invasive ventilation is increasingly used for respiratory support in preterm infants, and is associated with a lower risk of chronic lung disease. However, this mode is often not successful in the extremely preterm infant in part due to their markedly increased chest wall compliance that does not provide enough structure against which the forces of inhalation can generate sufficient pressure. To address the continued challenge of studying treatments in this fragile population, we developed a nonlinear lumped-parameter respiratory system mechanics model of the extremely preterm infant that incorporates nonlinear lung and chest wall compliances and lung volume parameters tuned to this population...
2018: PloS One
Hatice Bodur, Fatma Gül Yurdakul, Şebnem Ataman, Yeşim Garip, Kemal Nas, Fikriye Figen Ayhan Fikriye Figen Ayhan, Özgür Akgül, Ayşen Akinci, Zuhal Altay, Murat Birtane, Derya Soy Buğdayci, Erhan Çapkin, Remzi Çevik, Tuncay Duruöz, Gülcan Gürer, Cahit Kaçar, Ayhan Kamanli, Ece Kaptanoğlu, Taciser Kaya, Hilal Kocabaş, Ömer Kuru, Meltem Alkan Melikoğlu, Erhan Özdemirel, Sumru Özel, Aylin Rezvani, İlhan Sezer, İsmihan Sunar, Gürkan Yilmaz
Objectives: This study aims to update 2011 Turkish League Against Rheumatism SpondyloArthritis Recommendations, and to compose a national expert opinion on management of axial spondyloArthritis under guidance of current guidelines, and implantation and dissemination of these international guidelines into our clinical practice. Patients and methods: A scientific committee of 28 experts consisting of 14 rheumatologists and 14 physical medicine and rehabilitation specialists (one of them also has an immunology PhD) was formed...
March 2018: Archives of Rheumatology
José Alberto Reis Parise, Francisco Eduardo Mourão Saboya
The data presented in this article are related to the research article entitled "Transport coefficients for developing laminar flow in isosceles triangular ducts" (Parise and Saboya, 1999) [1]. The article describes an experiment involving the determination of transport coefficients in the laminar entrance region of 30°, 45°, 60° and 90° isosceles triangular ducts. Data were obtained by application of the naphthalene sublimation technique in conjunction with the heat to mass transfer analogy. Experimental conditions (duct sides made of naphthalene and base made of metal) simulated developing velocity and temperature fields in an isosceles triangular duct with isothermal lateral walls and adiabatic base...
June 2018: Data in Brief
Pravin Salunke
The C1-2 joint is unique and is responsible for more than 50% of the neck rotation. The joints have an ergonomic design that allows maximum motion without getting dislocated. It provides six degrees of freedom, the maximum being axial rotation, and is a marvel of nature's engineering. The morphometry of lateral masses of C1 and C2 joints was analyzed to explain the possible movements despite minor variations. The normal morphometry was compared with the joints of individuals with congenital atlantoaxial dislocation...
January 2018: Journal of Pediatric Neurosciences
Dennis Kostka, Alisha K Holloway, Katherine S Pollard
Some of the fastest evolving regions of the human genome are conserved non-coding elements with many human-specific DNA substitutions. These Human Accelerated Regions (HARs) are enriched nearby regulatory genes, and several HARs function as developmental enhancers. To investigate if this evolutionary signature is unique to humans, we quantified evidence of accelerated substitutions in conserved genomic elements across multiple lineages and applied this approach simultaneously to the genomes of five apes: human, chimpanzee, gorilla, orangutan, and gibbon...
June 12, 2018: Molecular Biology and Evolution
Andreas Kramer, Jakob Kümmel, Albert Gollhofer, Gabriele Armbrecht, Ramona Ritzmann, Daniel Belavy, Dieter Felsenberg, Markus Gruber
Objective: Inactivity results in a marked loss of muscle function, especially in movements requiring high power, force, and rate of force development. The aim of the present study was to evaluate if jump training can prevent these deteriorating effects of physical inactivity. Methods: Performance and muscle activity during several types of jumps was assessed directly before and after 60 days of bed rest as well as during follow-up visits in 23 male participants. Participants in the jump training group (JUMP, 12 participants) trained 5-6x per week during the bed rest period in a sledge jump system that allows jumps in a horizontal position, whereas the control group (CTRL, 11 participants) did not train...
2018: Frontiers in Physiology
Yudong Qiu, Benedict R Schwegler, Lee-Ping Wang
We report a molecular dynamics (MD) simulation study of reverse osmosis desalination using nanoporous monolayer graphene passivated by SiH2 and Si(OH)2 functional groups. A highly accurate and detailed polarizable molecular mechanics force field model was developed for simulating graphene nanopores of various sizes and geometries. The simulated water fluxes and ion rejection percentages are explained using detailed atomistic mechanisms derived from analysis of the simulation trajectories. Our main findings are: (1) The Si(OH)2 pores possess superior ion rejection rates due to selective electrostatic repulsion of Cl- ions, but Na+ ions are attracted to the pore and block water transfer...
June 12, 2018: Journal of Chemical Theory and Computation
Jinchuang Zhang, Li Liu, Hongzhi Liu, Ashton Yoon, Syed S H Rizvi, Qiang Wang
Texturized Vegetable Protein (TVP), as the meat analogues, has aroused the attention due to the advantages of health and nutrition. During the extrusion process of TVP, under the comprehensive effects of temperature, shear force, and pressure, complex conformational changes and molecular interactions amongst protein, carbohydrate, lipid, and other components occur, which determine the quality of TVP. Control of the extrusion process is still a big challenge. Therefore, this review summarized the development and current status of food extrusion technology for the production of TVP and gave detailed descriptions about the conformational changes of the main components during the extrusion process, focusing on the effects of barrel temperature, moisture content, feed rate and screw speed on TVP quality...
June 12, 2018: Critical Reviews in Food Science and Nutrition
Theodore T Redman, Kevin E Mayberry, Alejandra G Mora, Brock A Benedict, Elliot M Ross, Julian G Mapp, Russ S Kotwal
BACKGROUND: Historically, documentation of prehospital combat casualty care has been relatively nonexistent. Without documentation, performance improvement of prehospital care and evacuation through data collection, consolidation, and scientific analyses cannot be adequately accomplished. During recent conflicts, prehospital documentation has received increased attention for point-of-injury care as well as for care provided en route on medical evacuation platforms. However, documentation on casualty evacuation (CASEVAC) platforms is still lacking...
2018: Journal of Special Operations Medicine: a Peer Reviewed Journal for SOF Medical Professionals
Jin-Dong Yang, Bao-Long Chen, Xiao-Qing Zhu
For a long time, it has been controversial that the three-step (e-H+-e) or two-step (e-H•) mechanism was used for the oxidations of NADH and its models by metal ions in non-alkaline media. The latter mechanism has been accepted by the majority of researchers. In this work, 1-benzyl-1,4-dihydronicotinamide (BNAH) and 1-phenyl-l,4-dihydronicotinamide (PNAH) are used as NADH models, and ferrocenium (Fc+) metal ion as an electron acceptor. The kinetics for oxidations of the NADH models by Fc+ in pure acetonitrile were monitored by using UV-Vis absorption and quadratic relationship between of kobs and the concentrations of NADH models were found for the first time...
June 11, 2018: Journal of Physical Chemistry. B
Wenwen Xu, Zhiyi Lu, Xiaoming Sun, Lei Jiang, Xue Duan
Gas-involving electrochemical reactions, including gas evolution reactions and gas consumption reactions, are essential components of the energy conversion processes and gathering elevating attention from researchers. Besides the development of highly active catalysts, gas management during gas-involving electrochemical reactions is equally critical for industrial applications to achieve high reaction rates (hundreds of milliamperes per square centimeter) under practical operation voltages. Biomimetic surfaces, which generally show regular micro/nanostructures, offer new insights to address this issue because of their special wetting capabilities...
June 8, 2018: Accounts of Chemical Research
Stephen Randerson, Sally Casswell, Taisia Huckle
AIM: To assess the impact of the Sale and Supply of Alcohol Act 2012 (SSAA) on the alcohol environment from 2013 to 2015. METHOD: A mixed methods study incorporating key informant interviews and administrative data to assess changes between 2013 and 2015. Perceptions of the alcohol environment, policy enforcement and policy compliance were thematically analysed and quantitative ratings summarised. Concurrent changes to drink driving law were included. RESULTS: The SSAA led to a slight reduction in very late night availability in urban centres via the national 4am limit for on-licensed premises trading, which had strong compliance and enforcement...
June 8, 2018: New Zealand Medical Journal
Christiana J Raymond-Pope, Donald R Dengel, John S Fitzgerald, Tyler A Bosch
Raymond-Pope, CJ, Dengel, DR, Fitzgerald, JS, and Bosch, TA. Association of compartmental leg lean mass measured by dual X-ray absorptiometry with force production. J Strength Cond Res XX(X): 000-000, 2018-We recently reported a novel method for measuring upper leg anterior/posterior compartmental composition. The purpose of this study was to determine the association of this method with measures of muscle-specific and explosive strength and to compare this method with traditional dual energy X-ray absorptiometry (DXA) measurements of total and upper leg masses...
June 6, 2018: Journal of Strength and Conditioning Research
Ali Khodayari Bavil, Jungkyu Kim
A simple, reliable, and self-powered capillary flow-driven microfluidic platform is developed for conducting microparticle-labeled immunoassays. To obtain the washing forces and binding kinetics appropriate for microparticle-labeled immunoassays, both microchannel networks and sample access holes are designed and characterized to confirm the fluidic routes. To demonstrate two different types of immunoassays, serial and parallel capillary-driven microfluidic platforms were developed for mouse immunoglobulin G (IgG) and cardiac troponin I (cTnI) using detection antibody-conjugated microparticles, respectively...
June 7, 2018: Analyst
Jennifer J Buechel, Cynthia D Connelly
BACKGROUND: Human papillomavirus (HPV) is the most common sexually transmitted infection, with at least half of sexually active people contracting the virus-a leading etiology for genital warts and anal, cervical, laryngeal, penile, vaginal, and vulvar cancers. Research suggests HPV is higher among U.S. military personnel than in U.S. civilian populations and can result in significant morbidity or complications and limit U.S. military's duties or deployable status. OBJECTIVES: The aim of the study was to identify determinants of HPV vaccination among U...
June 5, 2018: Nursing Research
Mohammed Zidane, Said Safi, Mohamed Sabri
The aim of this research is to develop a non-linear blind estimator able to represents a Broadband Radio Access Networks (BRAN) channels. In the one hand, we have used Higher Order Statistics (HOS) theory to build our algorithm. Indeed, we develop a non-linear method based only on fourth order cumulants for identifying the diagonal parameters of quadratic systems. In the other hand, the developed approach is applied to estimate the experimental channels, BRAN A, C and E data normalized for MC-CDMA, in non-linear case...
April 2018: Data in Brief
Simon Grima, Jonathan V Spiteri, Mihajlo Jakovljevic, Carl Camilleri, Sandra C Buttigieg
In this study, we analyzed healthcare provision and health expenditure across six Mediterranean countries that adopt the National Health System (Beveridge model) and that form part of the European Union (EU) with the main aim being that of analyzing and comparing out-of-pocket health spending in countries with a European Mediterranean connection. To this end, we considered various economic indicators and statistics to derive commonalities and differences across these countries and also compared trends in these indicators to those observed across the rest of the EU...
2018: Frontiers in Public Health
Daniela Heilos, Clemens Röhrl, Christine Pirker, Bernhard Englinger, Dina Baier, Thomas Mohr, Michaela Schwaiger, Shahid Muhammad Iqbal, Sushilla van Schoonhoven, Kristaps Klavins, Tanja Eberhart, Ursula Windberger, Judith Taibon, Sonja Sturm, Hermann Stuppner, Gunda Koellensperger, Rita Dornetshuber-Fleiss, Walter Jäger, Rosa Lemmens-Gruber, Walter Berger
Destruxins, secondary metabolites of entomopathogenic fungi, exert a wide variety of interesting characteristics ranging from antiviral to anticancer effects. Although their mode of action was evaluated previously, the molecular mechanisms of resistance development are unknown. Hence, we have established destruxin-resistant sublines of HCT116 colon carcinoma cells by selection with the most prevalent derivatives, destruxin (dtx)A, dtxB and dtxE. Various cell biological and molecular techniques were applied to elucidate the regulatory mechanisms underlying these acquired and highly stable destruxin resistance phenotypes...
May 22, 2018: Oncotarget
Wanlong Wu, Suzana Jordan, Mike Oliver Becker, Rucsandra Dobrota, Britta Maurer, Håvard Fretheim, Shuang Ye, Elise Siegert, Yannick Allanore, Anna-Maria Hoffmann-Vold, Oliver Distler
OBJECTIVES: To identify the predictive clinical characteristics and establish a prediction model for the progression of mild interstitial lung disease (ILD) in patients with systemic sclerosis (SSc). METHODS: Patients with SSc from two independent prospective cohorts were included in this observational study. All patients fulfilled the 2013 American College of Rheumatology/European League Against Rheumatism criteria, had mild ILD at baseline diagnosed by High-Resolution Computed Tomography (HRCT), available baseline and ≥1 annual follow-up pulmonary function tests and no concomitant pulmonary hypertension or airflow obstruction...
June 6, 2018: Annals of the Rheumatic Diseases
Dingqiang Lu, Qiuda Xu, Guangchang Pang, Fuping Lu
An electrochemical double-layer Au nanoparticle membrane immunosensor was developed using an electrochemical biosensing signal amplification system with Au nanoparticles, thionine, chitosan, and horseradish peroxidase, which was fabricated using double self-adsorption of Au nanoparticle sol followed by anti-α-fetoprotein Balb/c mouse monoclonal antibody adsorption. The AuNPs sol was characterized by spectrum scanning and transmission electron microscopy. The immunosensor was characterized by atomic force microscopy, cyclic voltammetry, and alternating-current impedance during each stage of adsorption and assembly...
June 5, 2018: Biomedical Microdevices
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