keyword
https://read.qxmd.com/read/38537007/independent-predictors-for-non-alcoholic-fatty-liver-disease-in-patients-with-treatment-na%C3%A3-ve-chronic-hepatitis-b
#1
JOURNAL ARTICLE
Gulsah Tuncer, Ceyda Geyiktepe-Guclu, Osman Faruk Bayramlar, Burcu Atasoy Bozan, Cigdem Yucel, Betul Copur, Kadir Gorkem Guclu, Mustafa Yıldırım, Gonul Sengöz, Filiz Pehlivanoglu
OBJECTIVE: There are limited data on non-alcoholic fatty liver disease in chronic hepatitis B virus infection. We aimed to determine the predictors for non-alcoholic fatty liver disease in patients with treatment-naïve chronic hepatitis B virus infection. METHODS: All consecutive treatment-naïve patients with chronic hepatitis B virus infection at the Haseki Training and Research Hospital between October 1, 2021, and September 31, 2022, were retrospectively enrolled...
2024: Revista da Associação Médica Brasileira
https://read.qxmd.com/read/38535599/alterations-in-n-glycosylation-of-hcv-e2-protein-in-children-patients-with-ifn-rbv-therapy-failure
#2
JOURNAL ARTICLE
Karolina Zimmer, Alicja M Chmielewska, Paulina Jackowiak, Marek Figlerowicz, Krystyna Bienkowska-Szewczyk
The glycosylation of viral envelope proteins plays an important role in virus biology and the immune response of the host to infection. Hepatitis C virus (HCV) envelope proteins E1 and E2, key players in virus entry and spread, are highly N-glycosylated and possess 4 (5 in certain genotypes) to 11 conserved glycosylation sites, respectively. Many published results based on recombinant proteins indicate that the glycan shield can mask the epitopes targeted by neutralizing antibodies. Glycan shifting within the conserved linear E2 region (412-423) could be one of the escape strategies used by HCV...
March 15, 2024: Pathogens
https://read.qxmd.com/read/38535558/hepatitis-c-epidemiology-insights-from-a-comprehensive-cohort-study-in-asst-melegnano-and-martesana-lombardia-region-northern-italy
#3
JOURNAL ARTICLE
Michele Nardone, Dario Di Stasio, Alberta Lucchese, Daniele Gentili, Giulia Cattabianchi, Carlo Signorelli, Pierangelo Sarchi, Giovanna Pulcrano, Valentino Lembo, Paola Maria Pirola, Dorina Lauritano, Francesco Carinci
Hepatitis C virus (HCV) infection is a significant public health problem affecting 58 million people worldwide, including 3.9 million in Europe. Many of these infections go undiagnosed because chronic infection is often asymptomatic. This observational cohort study presents a detailed examination of hepatitis C virus epidemiology in Lombardia (Italy) and was conducted within the ASST "Melegnano e della Martesana". The study involved comprehensive HCV screening of 3290 patients accessing the collection points and/or hospitalized in the facilities of the ASST from 20 May 2022 to 13 April 2023...
February 28, 2024: Pathogens
https://read.qxmd.com/read/38535025/comparison-of-transient-elastography-and-point-shear-wave-elastography-for-analysis-of-liver-stiffness-a-prospective-study
#4
JOURNAL ARTICLE
Giuseppe Losurdo, Ilaria Ditonno, Domenico Novielli, Francesca Celiberto, Andrea Iannone, Antonino Castellaneta, Paola Dell'Aquila, Nunzio Ranaldo, Maria Rendina, Michele Barone, Enzo Ierardi, Alfredo Di Leo
Liver stiffness measurement (LSM) by Fibroscan is the most used non-invasive method to assess liver fibrosis. Recently, point-shear wave elastography (pSWE) has been introduced as a simple alternative non-invasive test. Therefore, we aimed to compare the results of these two techniques. One hundred and eighty-four consecutive patients attending our outpatient ultrasound clinic were recruited. LSM was performed by both Fibroscan and pSWE. Statistical analysis was conducted by Spearman's test for correlation and linear regression...
March 12, 2024: Diagnostics
https://read.qxmd.com/read/38534991/evaluation-of-two-assay-serological-testing-strategies-for-anti-hcv-screening-in-italian-populations-a-dual-screening-approach
#5
JOURNAL ARTICLE
Elena Zocca, Silva Seraceni, Teresa Cafaro, Tamara Emanuela Cervone, Laura Cardarelli, Massimiliano Valisi, Isabella Polidori, Massimo Pieri, Flaminia Tomassetti, Francesco Broccolo
(1) Background: Hepatitis C virus (HCV) screening mostly uses a one-assay anti-HCV testing approach, which has a higher probability of false-positive results in populations with low HCV prevalence. (2) Methods: In this investigation, 17,926 participants were screened for HCV, and the reactives were tested using a two-assay anti-HCV approach: Elecsys ElectroChemiLuminescence (ECL) and a ChemiLuminescence ImmunoAssay (CLIA), respectively. A recombinant immunoblot assay (RIBA) was performed to confirm anti-HCV positivity...
March 7, 2024: Diagnostics
https://read.qxmd.com/read/38534007/high-hepatitis-c-cure-rates-among-patients-with-alcohol-use-at-a-safety-net-hepatitis-c-clinic
#6
JOURNAL ARTICLE
Erica Heiman, Meghan Alexander, Rebecca Zhang, Ziduo Zheng, Lesley S Miller
OBJECTIVES: We set out to examine several aspects of the relationship between alcohol use and hepatitis C virus (HCV) among a cohort of patients treated at an HCV clinic within a safety net hospital. We examined (1) the prevalence of alcohol use among patients treated for HCV, (2) the likelihood of being started on treatment among patients who reported drinking alcohol compared with those who did not, and (3) the associations between alcohol use and HCV cure. METHODS: We performed a retrospective chart abstraction study using data from the Grady Liver Clinic, a specialty HCV clinic colocated in Grady Memorial Hospital's primary care clinic and run by general internists...
March 27, 2024: Journal of Addiction Medicine
https://read.qxmd.com/read/38533259/editorial-the-evolution-in-pharmacology-of-infectious-diseases-2022
#7
EDITORIAL
Exequiel O J Porta, Ali Saffaei, Karunakaran Kalesh
No abstract text is available yet for this article.
2024: Frontiers in Pharmacology
https://read.qxmd.com/read/38532435/liver-stiffness-and-associated-risk-factors-among-people-with-a-history-of-injecting-drugs-a-prospective-cohort-study
#8
JOURNAL ARTICLE
Karl Trygve Druckrey-Fiskaaen, Jørn Henrik Vold, Tesfaye Madebo, Håvard Midgard, Olav Dalgard, Rafael Alexander Leiva, Lars T Fadnes
BACKGROUND: Persons with opioid use disorders (OUD) and persons with substance use disorders (SUD) who inject substances have a reduced life expectancy of up to 25 years compared with the general population. Chronic liver diseases are a substantial cause of this. Screening strategies based on liver stiffness measurements (LSM) may facilitate early detection, timely intervention, and treatment of liver disease. This study aims to investigate the extent of chronic liver disease measured with transient elastography and the association between LSM and various risk factors, including substance use patterns, hepatitis C virus (HCV) infection, alcohol use, body mass index, age, type 2 diabetes mellitus, and high-density lipoprotein (HDL) cholesterol among people with OUD or with SUD who inject substances...
March 26, 2024: Substance Abuse Treatment, Prevention, and Policy
https://read.qxmd.com/read/38531730/hepatitis-c-virus-infection-and-co-infection-with-hiv-among-persons-who-inject-drugs-in-10-u-s-cities-national-hiv-behavioral-surveillance-2018
#9
JOURNAL ARTICLE
Johanna Chapin-Bardales, Alice Asher, Dita Broz, Eyasu Teshale, Tonya Mixson-Hayden, Amanda Poe, Senad Handanagic, Carlos Blanco, Cyprian Wejnert
BACKGROUND: Characterizing acute and chronic hepatitis C virus (HCV) infection and HIV/HCV co-infection among persons who inject drugs (PWID) can inform elimination efforts. METHODS: During 2018 National HIV Behavioral Surveillance in 10 U.S. metropolitan statistical areas (MSAs), PWID were recruited using respondent-driven sampling and offered a survey, HIV testing, and HCV antibody and RNA testing. We examined prevalence and associated characteristics of HCV infection and HIV/HCV co-infection...
March 25, 2024: International Journal on Drug Policy
https://read.qxmd.com/read/38530472/differences-in-branched-chain-amino-acid-to-tyrosine-ratio-btr-among-etiologies-of-chronic-liver-disease-progression-compared-to-healthy-adults
#10
JOURNAL ARTICLE
Masaaki Mino, Akitoshi Sano, Eiji Kakazu, Hiroko Matsubara, Keisuke Kakisaka, Takayuki Kogure, Katsunori Sekine, Yoshihiko Aoki, Masatoshi Imamura, Michitaka Matsuda, Taiji Yamazoe, Taizo Mori, Sachiyo Yoshio, Jun Inoue, Atsushi Masamune, Tatsuya Kanto
BACKGROUND: The branched-chain amino acids (BCAAs) to tyrosine (Tyr) ratio (BTR) test is used to evaluate the progression of chronic liver disease (CLD). However, the differences across sex, age, body mass index (BMI) and etiologies are still unclear. METHODS: We retrospectively reviewed data from 2,529 CLD cases with free amino acids (FAAs) in peripheral blood from four hospitals and 16,421 general adults with FAAs data from a biobank database. In total, 1,326 patients with CLD (covering seven etiologies) and 8,086 healthy controls (HCs) were analyzed after exclusion criteria...
March 26, 2024: Journal of Gastroenterology
https://read.qxmd.com/read/38528584/potential-use-of-proprotein-convertase-subtilisin-kexin-type-9-pcsk9-inhibition-and-prevention-method-in-viral-infection
#11
REVIEW
Khursheed Muzammil, Mohammad Hosseini Hooshiar, Shirin Varmazyar, Thabit Moath Omar, Manal Morad Karim, Sadeq Aadi, Shaylan Kalavi, Saman Yasamineh
Cellular lipid membranes serve as the primary barrier preventing viral infection of the host cell and provide viruses with a critical initial point of contact. Occasionally, viruses can utilize lipids as viral receptors. Viruses depend significantly on lipid rafts for infection at virtually every stage of their life cycle. The pivotal role that proprotein convertase subtilisin/kexin Type 9 (PCSK9) plays in cholesterol homeostasis and atherosclerosis, primarily by post-transcriptionally regulating hepatic low-density lipoprotein receptor (LDLR) and promoting its lysosomal degradation, has garnered increasing interest...
March 25, 2024: Microbial Cell Factories
https://read.qxmd.com/read/38528146/phosphatidylserine-exposing-extracellular-vesicles-in-body-fluids-are-an-innate-defence-against-apoptotic-mimicry-viral-pathogens
#12
JOURNAL ARTICLE
Rüdiger Groß, Hanna Reßin, Pascal von Maltitz, Dan Albers, Laura Schneider, Hanna Bley, Markus Hoffmann, Mirko Cortese, Dhanu Gupta, Miriam Deniz, Jae-Yeon Choi, Jenny Jansen, Christian Preußer, Kai Seehafer, Stefan Pöhlmann, Dennis R Voelker, Christine Goffinet, Elke Pogge-von Strandmann, Uwe Bunz, Ralf Bartenschlager, Samir El Andaloussi, Konstantin M J Sparrer, Eva Herker, Stephan Becker, Frank Kirchhoff, Jan Münch, Janis A Müller
Some viruses are rarely transmitted orally or sexually despite their presence in saliva, breast milk, or semen. We previously identified that extracellular vesicles (EVs) in semen and saliva inhibit Zika virus infection. However, the antiviral spectrum and underlying mechanism remained unclear. Here we applied lipidomics and flow cytometry to show that these EVs expose phosphatidylserine (PS). By blocking PS receptors, targeted by Zika virus in the process of apoptotic mimicry, they interfere with viral attachment and entry...
March 25, 2024: Nature Microbiology
https://read.qxmd.com/read/38524607/viruses-and-thrombocytopenia
#13
REVIEW
Reyhaneh Rasizadeh, Fatemeh Ebrahimi, Atefeh Zamani Kermanshahi, Amin Daei Sorkhabi, Aila Sarkesh, Javid Sadri Nahand, Hossein Bannazadeh Baghi
Thrombocytopenia, characterized by a decrease in platelet count, is a multifaceted clinical manifestation that can arise from various underlying causes. This review delves into the intriguing nexus between viruses and thrombocytopenia, shedding light on intricate pathophysiological mechanisms and highlighting the pivotal role of platelets in viral infections. The review further navigates the landscape of thrombocytopenia in relation to specific viruses, and sheds light on the diverse mechanisms through which hepatitis C virus (HCV), measles virus, parvovirus B19, and other viral agents contribute to platelet depletion...
March 30, 2024: Heliyon
https://read.qxmd.com/read/38524223/clinical-and-epidemiological-characteristics-of-the-2022-mpox-outbreak-in-spain-ceme-22-study
#14
JOURNAL ARTICLE
G Ramírez-Olivencia, M Velasco Arribas, M M Vera García, J Casabona, M J Martínez, F J Membrillo De Novales
BACKGROUND: We conducted a multicentric national study (SEIMC-CEME-22), to describe the clinical and epidemiological profile of the mpox outbreak in Spain, including the management of the disease. METHODS: This was a retrospective national observational study conducted by Sociedad Española de Enfermedades Infecciosas y Microbiología Clínica (SEIMC) and Foundation SEIMC-GESIDA. We included patients with a confirmed mpox diagnosis before 13 July 2022, and attended at the Spanish health network (the early phase of the outbreak)...
March 2024: Open Forum Infectious Diseases
https://read.qxmd.com/read/38523735/risk-factors-for-development-of-cirrhosis-in-chronic-viral-hepatitis-b-patients-who-had-persistent-viral-suppression-with-antiviral-therapy
#15
JOURNAL ARTICLE
Soe T Maung, Pakanat Decharatanachart, Sombat Treeprasertsuk, Roongruedee Chaiteerakij
BACKGROUND AND AIMS: Chronic viral hepatitis B (CHB)-infected patients occasionally develop cirrhosis despite having persistent viral suppression with antiviral therapy. We aimed to identify risk factors for developing cirrhosis in hepatitis B virus (HBV)-suppressed patients. METHODS: We conducted a case-control study involving 120 noncirrhotic CHB-infected patients achieving viral suppression with antiviral treatment, with 40 cases developing cirrhosis and 80 age-, sex-, and Fibrosis-4 (FIB-4)-matched controls...
2024: Journal of Clinical and Experimental Hepatology
https://read.qxmd.com/read/38523466/changing-etiology-and-epidemiology-of-hepatocellular-carcinoma-asia-and-worldwide
#16
JOURNAL ARTICLE
Do Young Kim
Approximately 80% of hepatocellular carcinoma (HCC) cases arise in sub-Saharan Africa and Eastern Asia, following a similarly high prevalence of chronic hepatitis B virus (HBV) carriers in these regions. The etiology and epidemiology of HCC have recently changed worldwide. Although HBV infection is the main contributor to HCC development, a slow but continuous decline in HBV infection rates has been reported since 1990. Owing to the widespread use of direct-acting antivirals, the incidence of hepatitis C virus-related HCC has remarkably decreased in Japan and European countries...
March 25, 2024: Journal of liver cancer
https://read.qxmd.com/read/38522854/comparison-of-glecaprevir-pibrentasvir-and-sofosbuvir-ledipasvir-in-patients-with-hepatitis-c-virus-genotype-1-and-2-in-south-korea
#17
JOURNAL ARTICLE
Hyun Deok Shin, Il Han Song, Sae Hwan Lee, Hong Soo Kim, Tae Hee Lee, Hyuk Soo Eun, Seok Hyun Kim, Byung Seok Lee, Hee Bok Chae, Seok Hwan Kim, Myung Joon Song, Soon Yeong Ko, Suk Bae Kim
BACKGROUND/AIMS: This study compared the effectiveness and safety of glecaprevir/pibrentasvir (GLE/PIB) and sofosbuvir/ledipasvir (SOF/LDV) in real-life clinical practice. METHODS: The data from genotype 1 or 2 chronic hepatitis C patients treated with GLE/PIB or sofosbuvir + ribavirin or SOF/LDV in South Korea were collected retrospectively. The analysis included the treatment completion rate, sustained virologic response at 12 weeks (SVR12) test rate, treatment effectiveness, and adverse events...
March 25, 2024: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
https://read.qxmd.com/read/38521947/hiv-and-hepatitis-b-c-co-infection-and-correlates-of-hiv-infection-among-men-who-have-sex-with-men-in-rwanda-2021-a-respondent-driven-sampling-cross-sectional-study
#18
JOURNAL ARTICLE
Eric Remera, Elysee Tuyishime, Catherine Kayitesi, Samuel S Malamba, Beata Sangwayire, Justine Umutesi, Horacio Ruisenor-Escudero, Tom Oluoch
BACKGROUND: Men who have sex with men (MSM) are a key population group disproportionately affected by HIV and other sexually transmitted infections (STIs) worldwide. In Rwanda, the HIV epidemic remains a significant public health concern, and understanding the burden of HIV and hepatitis B and C coinfections among MSM is crucial for designing effective prevention and control strategies. This study aims to determine the prevalence of HIV, hepatitis B, and hepatitis C infections among MSM in Rwanda and identify correlates associated with HIV infection within this population...
March 23, 2024: BMC Infectious Diseases
https://read.qxmd.com/read/38521523/psychoeducational-interventions-for-people-living-with-chronic-communicable-disease-a-systematic-review
#19
JOURNAL ARTICLE
Aoife Burke, Martin P Davoren, Ella Arensman, Janas M Harrington
OBJECTIVE: Psychoeducation is increasingly recognised for its value in facilitating adaption to a chronic disease diagnosis. This study aimed to synthesise available literature on the psychoeducation interventions available to adults living with chronic communicable disease. METHODS: PubMed, CINAHL, Embase, SocINDEX, PsycINFO and PsycArticles were systematically searched up to May 2023. Peer-reviewed studies, published in English, investigating the impact of psychoeducational interventions on adults living with chronic communicable disease were included, across a range of outcome measures...
March 23, 2024: BMJ Open
https://read.qxmd.com/read/38521170/post-treatment-lsm-rather-than-change-during-treatment-predicts-decompensation-in-patients-with-cacld-after-hcv-cure
#20
JOURNAL ARTICLE
Georg Semmler, Sonia Alonso López, Monica Pons, Sabela Lens, Elton Dajti, Marie Griemsmann, Alberto Zanetto, Lukas Burghart, Stefanie Hametner-Schreil, Lukas Hartl, Marisa Manzano, Sergio Rodriguez-Tajes, Paola Zanaga, Michael Schwarz, María Luisa Gutierrez, Mathias Jachs, Anna Pocurull, Benjamín Polo, Dominik Ecker, Beatriz Mateos, Sonia Izquierdo, Yolanda Real, Adriana Ahumada, David Josef Maria Bauer, Jim Benjamin Mauz, Michelle Casanova-Cabral, Michael Gschwantler, Francesco Paolo Russo, Francesco Azzaroli, Benjamin Maasoumy, Thomas Reiberger, Xavier Forns, Joan Genesca, Rafael Bañares, Mattias Mandorfer
BACKGROUND & AIMS: Baveno VII has defined a clinically significant (i.e., prognostically meaningful) liver stiffness measurement (LSM)-decrease in cACLD by ≥20% associated with a final LSM<20 kPa, or any decrease to <10 kPa. However, these rules have not yet been validated against direct clinical endpoints. METHODS: We retrospectively analysed cACLD patients (LSM≥10 kPa) with paired liver stiffness measurement (LSM) before (BL) and after (FU) HCV-cure by interferon-free therapies from 15 European centers...
March 21, 2024: Journal of Hepatology
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