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https://www.readbyqxmd.com/read/28749551/a-novel-allele-hla-b-27-149-identified-by-sequence-based-typing-in-a-chinese-individual
#1
J Wang, Y Zhang, Q Li, K Ru, X Wang
HLA-B*27:149 differs from HLA-B*27:04:01 (488C->T, exon 3, A139V).
July 27, 2017: HLA
https://www.readbyqxmd.com/read/28749455/primary-biliary-cholangitis-alters-functional-connections-of-the-brain-s-deep-gray-matter
#2
Victoria A L Mosher, Mark G Swain, Jack X Q Pang, Gilaad G Kaplan, Keith A Sharkey, Glenda M MacQueen, Bradley G Goodyear
OBJECTIVES: Fatigue, itch, depressed mood, and cognitive impairment significantly impact the quality of life of many patients with primary biliary cholangitis (PBC). Previous neuroimaging studies of non-hepatic diseases suggest that these symptoms are often associated with dysfunction of deep gray matter brain regions. We used resting-state functional magnetic resonance imaging (rsfMRI) to determine whether PBC patients exhibit altered functional connections of deep gray matter. METHODS: Twenty female non-cirrhotic PBC patients and 21 age/gender-matched controls underwent rsfMRI...
July 27, 2017: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/28749365/discriminative-joint-feature-topic-model-with-dual-constraints-for-wce-classification
#3
Yixuan Yuan, Xiwen Yao, Junwei Han, Lei Guo, Max Q-H Meng
Wireless capsule endoscopy (WCE) enables clinicians to examine the digestive tract without any surgical operations, at the cost of a large amount of images to be analyzed. The main challenge for automatic computer-aided diagnosis arises from the difficulty of robust characterization of these images. To tackle this problem, a novel discriminative joint-feature topic model (DJTM) with dual constraints is proposed to classify multiple abnormalities in WCE images. We first propose a joint-feature probabilistic latent semantic analysis (PLSA) model, where color and texture descriptors extracted from same image patches are jointly modeled with their conditional distributions...
July 25, 2017: IEEE Transactions on Cybernetics
https://www.readbyqxmd.com/read/28749334/are-pertussis-cases-reported-too-late-for-public-health-interventions-retrospective-analysis-of-cases-in-london-and-south-east-england-2010-to-2015
#4
Helen Crabbe, María Saavedra-Campos, Neville Q Verlander, Anusha Leonard, Jill Morris, Amanda Wright, Sooria Balasegaram
In the United Kingdom, pertussis guidance recommends prophylaxis for household contacts within 21 days of case symptom onset if the household includes a vulnerable contact. The aim of our study was to identify characteristics associated with cases reported late for public health action. We reviewed the epidemiology of cases reported in London and South East England for the period 2010 to 2015. We characterised risk factors associated with late reporting of cases and described public health actions taken on timely reported cases...
July 20, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28749307/recurrent-ear-mite-otodectes-cynotis-infestation-in-three-related-groups-of-patagonian-cavies-dolichotis-patagonum
#5
Carolina Lopes da Cruz, Torres Alpino, Jack Kottwitz
:  Two of three groups of Patagonian cavies ( Dolichotis patagonum ) contracted Otodectes cynotis infestations after exposure to mite-infested feral cats. Otodectes cynotis infestations were initially identified in 9 of 10 cavies in group 1. Multiple feral cats with O. cynotis infestations were observed in the vicinity of the Patagonian cavies and were subsequently removed. The Patagonian cavies were initially treated with ivermectin (0.4 mg/kg s.q.) every 2 wk, but ivermectin was discontinued after the third treatment due to injury to one of the Patagonian cavies during capture...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749149/diversity-shrinkage-cross-validating-pareto-optimal-weights-to-enhance-diversity-via-hiring-practices
#6
Q Chelsea Song, Serena Wee, Daniel A Newman
To reduce adverse impact potential and improve diversity outcomes from personnel selection, one promising technique is De Corte, Lievens, and Sackett's (2007) Pareto-optimal weighting strategy. De Corte et al.'s strategy has been demonstrated on (a) a composite of cognitive and noncognitive (e.g., personality) tests (De Corte, Lievens, & Sackett, 2008) and (b) a composite of specific cognitive ability subtests (Wee, Newman, & Joseph, 2014). Both studies illustrated how Pareto-weighting (in contrast to unit weighting) could lead to substantial improvement in diversity outcomes (i...
July 27, 2017: Journal of Applied Psychology
https://www.readbyqxmd.com/read/28748977/solvent-dependent-photo-induced-dynamics-in-a-non-rigidly-linked-zinc-phthalocyanine-perylenediimide-dyad-probed-using-ultrafast-spectroscopy
#7
Bryan Kudisch, Margherita Maiuri, Vicente M Blas-Ferrando, Javier Ortiz, Ángela Sastre-Santos, Gregory D Scholes
In this work, we characterize the energy and electron transfer kinetics of a zinc phthalocyanine-perylenediimide dyad (ZnPc-PDI) in various solvents using steady-state and tunable narrowband pump-probe spectroscopy. We fit the ultrafast data with global analysis techniques and find that upon excitation of the PDI moiety (pump pulse at 540 nm), the excitation energy transfer (EET) rate to the ZnPc moiety displays a solvent sensitivity that we attribute to changes in the relative equilibrium moiety orientation...
July 27, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28748879/early-clinical-manifestations-and-laboratory-findings-before-and-after-treatment-of-cytomegalovirus-infection-in-kidney-transplant-patients
#8
Wasim Ahmed Siddiqui, Issa Al Salmi, Amitabh Jha, Abbas Pakkyara, Mohammad Yasir, Faissal A M Shaheen
Cytomegalovirus (CMV) is one of the most frequently encountered opportunistic viral pathogens in kidney transplant recipients. In this study, we retrospectively reviewed all living related and unrelated kidney transplant recipients on regular follow-up from January 2006 to June 2015, who were suspected to have CMV clinically and confirmed by DNA polymerase chain reaction (PCR). CMV PCR was detected in 102 kidney transplant recipients. The median time of detection after kidney transplant was 21 months, ranging from 15 days to 84 months...
July 2017: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/28748837/the-seroprevalence-of-coxiella-burnetii-in-erzincan-turkey-identification-of-the-risk-factors-and-their-relationship-with-geographical-features
#9
Aytekin Cikman, Merve Aydin, Baris Gulhan, Faruk Karakecili, Adalet Ozcicek, Ozan Arif Kesik, Mehmet Parlak, Fatih Ozcelik, Bilge Gültepe
BACKGROUND & OBJECTIVES: Coxiella burnetii (C. burnetii) bacterium, the causative agent of Q fever has regained importance due to the increasing cases of infections and outbreaks. A cross-sectional descriptive study was conducted to investigate the seroprevalence of C. burnetii in human populations of Erzincan province located in the eastern Turkey, identify the risk factors, and to explore the relationship between geographical features. METHODS: A total of 368 people residing in the rural (306) and urban (62) areas of the province were included in the study...
April 2017: Journal of Vector Borne Diseases
https://www.readbyqxmd.com/read/28748772/epidemiology-and-hospital-readmission-associated-with-complications-of-staphylococcus-aureus-bacteremia-in-pediatrics-over-a-25-year-period
#10
J LE, Q Dam, T Tran, A Nguyen, F C Adler-Shohet, S Kim, K Schmidt, J M Lieberman, J S Bradley
We sought to comprehensively assess the prevalence and outcomes of complications associated with Staphylococcus aureus bacteremia (SAB) in children. Secondarily, prevalence of methicillin resistance and outcomes of complications from methicillin-resistant S. aureus (MRSA) vs. methicillin-susceptible S. aureus SAB were assessed. This is a single-center cross-sectional study of 376 patients ⩽18 years old with SAB in 1990-2014. Overall, 197 (52%) patients experienced complications, the most common being osteomyelitis (33%), skin and soft tissue infection (31%), and pneumonia (25%)...
July 27, 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28748633/depression-and-anxiety-in-multiple-system-atrophy
#11
L-Y Zhang, B Cao, Y-T Zou, Q-Q Wei, R-W Ou, B Zhao, Y Wu, H-F Shang
BACKGROUND: It has been noticed that the patients with multiple system atrophy (MSA) can accompany with depression and anxiety. This study aimed to establish the incidence and determinants of depression and anxiety symptoms in Chinese MSA patients. METHODS: A total of 237 MSA patients were enrolled in the study. Neuropsychological assessment was performed using Hamilton Depression Rating Scale-24 items and Hamilton Anxiety Rating Scale. RESULTS: We found that 62...
July 26, 2017: Acta Neurologica Scandinavica
https://www.readbyqxmd.com/read/28748441/ozone-risk-assessment-in-three-oak-species-as-affected-by-soil-water-availability
#12
Yasutomo Hoshika, Barbara Moura, Elena Paoletti
To derive ozone (O3) dose-response relationships for three European oak species (Quercus ilex, Quercus pubescens, and Quercus robur) under a range of soil water availability, an experiment was carried out with 2-year-old potted seedlings exposed to three levels of water availability in the soil and three levels of O3 pollution for one growing season in an ozone free-air controlled exposure (FACE) facility. Total biomass losses were estimated relative to a hypothetical clean air at the pre-industrial age, i...
July 27, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748436/organophosphorus-pesticide-mixture-removal-from-environmental-matrices-by-a-soil-streptomyces-mixed-culture
#13
Gabriela Briceño, Karen Vergara, Heidi Schalchli, Graciela Palma, Gonzalo Tortella, María Soledad Fuentes, María Cristina Diez
The current study aimed to evaluate the removal of a pesticide mixture composed of the insecticides chlorpyrifos (CP) and diazinon (DZ) from liquid medium, soil and a biobed biomixture by a Streptomyces mixed culture. Liquid medium contaminated with 100 mg L(-1) CP plus DZ was inoculated with the Streptomyces mixed culture. Results indicated that microorganisms increased their biomass and that the inoculum was viable. The inoculum was able to remove the pesticide mixture with a removal rate of 0.036 and 0...
July 26, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28748350/expression-of-adenylate-kinase-fused-mek1r4f-in-escherichia-coli-and-its-application-in-erk-phosphorylation
#14
Fang Yang, Hongtao Li
OBJECTIVE: To construct a highly expressed and active MEK1R4F (a constitutively active form of mitogen-activated protein kinase kinase 1) by fusion of soluble adenylate kinase (Adk) tag, resulting in Adk-MEK1R4F protein suitable for preparation of phosphorylated ERK. RESULTS: We fused the Adk to the N-terminus of MEK1R4F through overlapping PCR. The expression of Adk-MEK1R4F fusion protein increased ~10-fold in Escherichia coli, and was purified to 95% via two purification steps including Ni-NTA and Q Sepharose fast flow (QFF) chromatography...
July 26, 2017: Biotechnology Letters
https://www.readbyqxmd.com/read/28747753/corrigendum-protein-structure-guided-discovery-of-functional-mutations-across-19-cancer-types
#15
Beifang Niu, Adam D Scott, Sohini Sengupta, Matthew H Bailey, Prag Batra, Jie Ning, Matthew A Wyczalkowski, Wen-Wei Liang, Qunyuan Zhang, Michael D McLellan, Sam Q Sun, Piyush Tripathi, Carolyn Lou, Kai Ye, R Jay Mashl, John Wallis, Michael C Wendl, Feng Chen, Li Ding
No abstract text is available yet for this article.
July 27, 2017: Nature Genetics
https://www.readbyqxmd.com/read/28747717/contextual-connectivity-a-framework-for-understanding-the-intrinsic-dynamic-architecture-of-large-scale-functional-brain-networks
#16
Rastko Ciric, Jason S Nomi, Lucina Q Uddin, Ajay B Satpute
Investigations of the human brain's connectomic architecture have produced two alternative models: one describes the brain's spatial structure in terms of static localized networks, and the other describes the brain's temporal structure in terms of dynamic whole-brain states. Here, we used tools from connectivity dynamics to develop a synthesis that bridges these models. Using resting fMRI data, we investigated the assumptions undergirding current models of the human connectome. Consistent with state-based models, our results suggest that static localized networks are superordinate approximations of underlying dynamic states...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747706/titanium-dioxide-engineered-for-near-dispersionless-high-terahertz-permittivity-and-ultra-low-loss
#17
Chuying Yu, Yang Zeng, Bin Yang, Robert Donnan, Jinbao Huang, Zhaoxian Xiong, Amit Mahajan, Baogui Shi, Haitao Ye, Russell Binions, Nadezda V Tarakina, Mike J Reece, Haixue Yan
Realising engineering ceramics to serve as substrate materials in high-performance terahertz(THz) that are low-cost, have low dielectric loss and near-dispersionless broadband, high permittivity, is exceedingly demanding. Such substrates are deployed in, for example, integrated circuits for synthesizing and converting nonplanar and 3D structures into planar forms. The Rutile form of titanium dioxide (TiO2) has been widely accepted as commercially economical candidate substrate that meets demands for both low-loss and high permittivities at sub-THz bands...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747624/number-of-infection-events-per-cell-during-hiv-1-cell-free-infection
#18
Yusuke Ito, Azaria Remion, Alexandra Tauzin, Keisuke Ejima, Shinji Nakaoka, Yoh Iwasa, Shingo Iwami, Fabrizio Mammano
HIV-1 accumulates changes in its genome through both recombination and mutation during the course of infection. For recombination to occur, a single cell must be infected by two HIV strains. These coinfection events were experimentally demonstrated to occur more frequently than would be expected for independent infection events and do not follow a random distribution. Previous mathematical modeling approaches demonstrated that differences in target cell susceptibility can explain the non-randomness, both in the context of direct cell-to-cell transmission, and in the context of free virus transmission (Q...
July 26, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28747206/laparoscopic-sacrocolpopexy-versus-vaginal-sacrospinous-fixation-for-vaginal-vault-prolapse-a-randomized-controlled-trial-salto-2-trial-study-protocol
#19
Anne-Lotte W M Coolen, Mèlanie N van IJsselmuiden, Anique M J van Oudheusden, J Veen, Hugo W F van Eijndhoven, Ben Willem J Mol, Jan Paul Roovers, Marlies Y Bongers
BACKGROUND: Hysterectomy is one of the most performed surgical procedures during lifetime. Almost 10 % of women who have had a hysterectomy because of prolapse symptoms, will visit a gynaecologist for a surgical correction of a vaginal vault prolapse thereafter. Vaginal vault prolapse can be corrected by many different surgical procedures. A Cochrane review comparing abdominal sacrocolpopexy to vaginal sacrospinous fixation considered the open abdominal procedure as the treatment of first choice for prolapse of the vaginal vault, although operation time and hospital stay is longer...
July 26, 2017: BMC Women's Health
https://www.readbyqxmd.com/read/28747095/simulation-based-sensitivity-analysis-for-non-ignorably-missing-data
#20
Peng Yin, Jian Q Shi
Sensitivity analysis is popular in dealing with missing data problems particularly for non-ignorable missingness, where full-likelihood method cannot be adopted. It analyses how sensitively the conclusions (output) may depend on assumptions or parameters (input) about missing data, i.e. missing data mechanism. We call models with the problem of uncertainty sensitivity models. To make conventional sensitivity analysis more useful in practice we need to define some simple and interpretable statistical quantities to assess the sensitivity models and make evidence based analysis...
January 1, 2017: Statistical Methods in Medical Research
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