keyword
https://read.qxmd.com/read/38537141/first-record-of-diplodia-gallae-causing-branch-cankers-on-declining-scarlet-oak-quercus-coccinea-in-virginia
#1
JOURNAL ARTICLE
Devin Bily, Tashi Gyatso, Matt Wolanski, Amanda Conrad, Connor Goolsby, Lori A Chamberlin, Katlin M DeWitt
Members of Botryosphaeria s.l. have an extensive history as cankering pathogens of stressed and declining oak trees in the eastern United States (Ferreira et al. 2021). The host range, distribution, and virulence among two closely related species, Diplodia corticola and D. gallae, remains unclear (Brazee et al. 2023). On 15 August 2023, a survey was conducted at a declining natural hardwood site in Shenandoah County, Virginia (GPS coordinates 38.922089, -78.606125). One mature Quercus coccinea tree that displayed scorched leaf margins and branch dieback was felled and a cankered branch from the crown was sampled (Fig...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537056/perioperative-outcomes-and-long-term-survival-of-cryosurgery-on-unresectable-pancreatic-cancer-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Kang Xue, Xiaofeng Liu, Xiaolin Xu, Li Wang, Bole Tian
BACKGROUND: Pancreatic cancer (PC) continues to rank as one of the deadliest forms of cancer, with the majority of patients being diagnosed with unresectable disease. The implementation of cryoablation-based comprehensive treatment is expected to lead to a reduction in tumor size and potentially achieve complete resection. However, the availability of systematic and evidence-based treatment guidelines for cryoablation in pancreatic cancer is currently limited. MATERIALS AND METHODS: A computerized search was conducted in the Medline, Embase, Cochrane Library databases, and Clinicaltrials to retrieve studies published from August 1987 to June 2023...
April 3, 2024: International Journal of Surgery
https://read.qxmd.com/read/38537050/deep-anterior-lamellar-keratoplasty-and-penetrating-keratoplasty-in-macular-corneal-dystrophy-comparison-of-visual-and-topographic-outcomes-and-complications
#3
JOURNAL ARTICLE
Ayşe Tüfekçi Balıkçı, Ayşe Burcu, Züleyha Yalnız Akkaya, Evin Singar, Selma Uzman
PURPOSES: This study aims to assess and compare the postoperative visual and topographic outcomes, complications, and graft survival rates following deep anterior lamellar keratoplasty and penetrating keratoplasty in patients with macular corneal dystrophy. METHODS: In this study we enrolled 59 patients (23 male; and 36 female) with macular corneal dystrophy comprising 81 eyes. Out of these, 64 eyes underwent penetrating keratoplasty, while 17 eyes underwent deep anterior lamellar keratoplasty...
2024: Arquivos Brasileiros de Oftalmologia
https://read.qxmd.com/read/38536960/unveiling-the-molecular-characteristics-origins-and-formation-mechanism-of-reduced-nitrogen-organic-compounds-in-the-urban-atmosphere-of-shanghai-using-a-versatile-aerosol-concentration-enrichment-system
#4
JOURNAL ARTICLE
Munila Abudumutailifu, Xiaona Shang, Lina Wang, Miaomiao Zhang, Huihui Kang, Yunqian Chen, Ling Li, Ruiting Ju, Bo Li, Huiling Ouyang, Xu Tang, Chunlin Li, Lin Wang, Xinke Wang, Christian George, Yinon Rudich, Renhe Zhang, Jianmin Chen
Reduced nitrogen-containing organic compounds (NOCs) in aerosols play a crucial role in altering their light-absorption properties, thereby impacting regional haze and climate. Due to the low concentration levels of individual NOCs in the air, the utilization of accurate detection and quantification technologies becomes essential. For the first time, this study investigated the diurnal variation, chemical characteristics, and potential formation pathways of NOCs in urban ambient aerosols in Shanghai using a versatile aerosol concentration enrichment system (VACES) coupled with HPLC-Q-TOF-MS...
March 27, 2024: Environmental Science & Technology
https://read.qxmd.com/read/38536880/bias-in-the-arrival-of-variation-can-dominate-over-natural-selection-in-richard-dawkins-s-biomorphs
#5
JOURNAL ARTICLE
Nora S Martin, Chico Q Camargo, Ard A Louis
Biomorphs, Richard Dawkins's iconic model of morphological evolution, are traditionally used to demonstrate the power of natural selection to generate biological order from random mutations. Here we show that biomorphs can also be used to illustrate how developmental bias shapes adaptive evolutionary outcomes. In particular, we find that biomorphs exhibit phenotype bias, a type of developmental bias where certain phenotypes can be many orders of magnitude more likely than others to appear through random mutations...
March 2024: PLoS Computational Biology
https://read.qxmd.com/read/38536656/development-of-a-diagnostic-model-for-pre-washout-screening-of-primary-aldosteronism
#6
JOURNAL ARTICLE
Q Wang, H Dong, H-W Li, Z-H Zheng, Y-Z Liu, Y-H Hua, Y-J Xiong, H-M Zhang, L Song, Y-B Zou, X-J Jiang
PURPOSE: Primary aldosteronism (PA) diagnosis is affected by antihypertensive drugs that are commonly taken by patients with suspected PA. In this study, we developed and validated a diagnostic model for screening PA without drug washout. METHODS: We retrospectively analyzed 1095 patients diagnosed with PA or essential hypertension. Patients were randomly grouped into training and validation sets at a 7:3 ratio. Baseline characteristics, plasma aldosterone concentration (PAC), and direct renin concentration (DRC) before and after drug washout were separately recorded, and the aldosterone-to-renin ratio (ARR) was calculated...
March 27, 2024: Journal of Endocrinological Investigation
https://read.qxmd.com/read/38536586/prevalence-of-and-factors-associated-with-financial-toxicity-after-pancreatectomy-and-gastrectomy
#7
JOURNAL ARTICLE
Yuki Hirata, Connie To, Heather Lyu, Grace L Smith, Joyce P Samuel, Hop S Tran Cao, Brian D Badgwell, Matthew H G Katz, Naruhiko Ikoma
BACKGROUND: Financial toxicity (FT) refers to the adverse impact of cancer treatment costs on patients' experiences, potentially leading to poor adherence to treatment and outcomes. However, the prevalence of FT among patients undergoing major upper gastrointestinal cancer operations, as well as factors associated with FT, remain unclear. METHODS: We conducted a cross-sectional study by sending the Comprehensive Score for financial Toxicity (COST) survey and Surgery-Q (a survey specifically developed for this study) to patients who underwent gastrectomy or pancreatectomy for malignant disease at our institution in 2019-2021...
March 27, 2024: Annals of Surgical Oncology
https://read.qxmd.com/read/38536561/exploring-the-causal-relationship-between-takayasu-arteritis-and-inflammatory-bowel-disease-using-mendelian-randomization
#8
JOURNAL ARTICLE
Xiaoli Pang, Huizhong Yang, Chi Wang, Suyan Tian
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have reported many cases of IBD-TA coexistence. Additionally, the incidence of IBD in patients with TA is estimated to be significantly higher than the incidence in the general population. Therefore, the two diseases are anticipated to be linked. Mendelian randomization (MR) analysis assesses whether an exposure might causally affect an outcome by using genetic variants inherited randomly at conception, thereby reducing the impact of confounding and reverse causality...
March 27, 2024: Immunologic Research
https://read.qxmd.com/read/38536471/prevalence-of-swallowing-disorder-in-different-dementia-subtypes-among-older-adults-a-meta-analysis
#9
JOURNAL ARTICLE
Alfiani Rahmi Putri, Yu-Hao Chu, Ruey Chen, Kai-Jo Chiang, Kondwani Joseph Banda, Doresses Liu, Hui-Chen Lin, Shu-Fen Niu, Kuei-Ru Chou
BACKGROUND: Ageing process and abnormal protein accumulation in dementia damage neural pathways affecting the swallowing process and leading to swallowing disorder. OBJECTIVE: To estimate the prevalence of swallowing disorder among older adults with different dementia subtypes. METHODS: We conducted a systematic search across multiple databases, including PubMed, Embase, Scopus, Web of Science and OVID Medline. The meta-analysis employed R (version 4...
March 1, 2024: Age and Ageing
https://read.qxmd.com/read/38536446/metformin-treatment-reduces-the-incidence-of-osteoporosis-a-two-sample-mendelian-randomized-study
#10
JOURNAL ARTICLE
Yaotian Cai, Gao Jun, Xiaojie Zhuang
UNLABELLED: It remains unclear whether the association between metformin and osteoporosis (OP) risk is causal. This two-sample Mendelian randomization (MR) study suggests a causal relationship between metformin treatment and a decrease in OP and fracture incidence, as well as an increase in bone mineral density (BMD) in the lumbar spine, femoral neck, and heel. Nonetheless, no significant causal effect is observed on forearm BMD. PURPOSE: We utilize a MR approach to investigate the association between metformin treatment and the risk of OP...
March 27, 2024: Osteoporosis International
https://read.qxmd.com/read/38536005/identification-of-compounds-that-impact-consumer-flavor-liking-of-american-european-hazelnut-hybrids-using-nontargeted-lc-ms-analysis
#11
JOURNAL ARTICLE
Mengying Fu, Edisson Tello, Emmanuel Hatzakis, Devin G Peterson
American-European ( Corylus americana × Corylus avellana ) hazelnut hybrids are being developed for the Midwest-growing region of the United States. However, an inadequate understanding of the compounds that impact the consumer acceptance of hazelnuts limits breeding programs. Nontargeted liquid chromatography/mass spectrometry (LC/MS) chemical profiles of 12 roasted hybrid hazelnut samples and the corresponding consumer flavor liking scores were modeled by orthogonal partial least squares with good fit and predictive ability ( R 2 Y > 0...
March 27, 2024: Journal of Agricultural and Food Chemistry
https://read.qxmd.com/read/38535852/machine-learning-techniques-for-canine-myxomatous-mitral-valve-disease-classification-integrating-anamnesis-quality-of-life-survey-and-physical-examination
#12
JOURNAL ARTICLE
Javier Engel-Manchado, José Alberto Montoya-Alonso, Luis Doménech, Oscar Monge-Utrilla, Yamir Reina-Doreste, Jorge Isidoro Matos, Alicia Caro-Vadillo, Laín García-Guasch, José Ignacio Redondo
Myxomatous mitral valve disease (MMVD) is a prevalent canine cardiac disease typically diagnosed and classified using echocardiography. However, accessibility to this technique can be limited in first-opinion clinics. This study aimed to determine if machine learning techniques can classify MMVD according to the ACVIM classification (B1, B2, C, and D) through a structured anamnesis, quality of life survey, and physical examination. This report encompassed 23 veterinary hospitals and assessed 1011 dogs for MMVD using the FETCH-Q quality of life survey, clinical history, physical examination, and basic echocardiography...
March 6, 2024: Veterinary Sciences
https://read.qxmd.com/read/38535825/comprehensive-analysis-of-bufadienolide-and-protein-profiles-of-gland-secretions-from-medicinal-bufo-species
#13
JOURNAL ARTICLE
Yunge Fang, Liangmian Chen, Pengfei Wang, Yating Liu, Yuxiu Wang, Zhimin Wang, Yue Ma, Huimin Gao
Toad Venom (TV) is the dried product of toxic secretions from Bufo bufo gargarizans Cantor (BgC) or B. melanostictus Schneider (BmS). Given the increasing medical demand and the severe depletion of wild toads, a number of counterfeit TVs appeared on the market, posing challenges to its quality control. In order to develop an efficient, feasible, and comprehensive approach to evaluate TV quality, a thorough analysis and comparison of chemical compounds among legal species BgC and BmS, as well as the main confusion species B...
March 20, 2024: Toxins
https://read.qxmd.com/read/38535340/taxonomic-and-functional-diversity-of-flower-visiting-insects-in-coffee-crops
#14
JOURNAL ARTICLE
Juan Diego Maldonado-Cepeda, Jesús Hernando Gómez, Pablo Benavides, Juliana Jaramillo, Zulma Nancy Gil
Despite the important role that flower-visiting insects play in agricultural production, none of the previous studies of coffee pollinators in Colombia have incorporated functional diversity into their analysis. Therefore, this study aimed to quantify the abundance, richness, and functional diversity of insects that visit flowers in coffee crops. Twenty-eight plots were selected among five sites in the north, center, and south of Colombia. In each plot, coffee flower insect visitors were collected and recorded on 90 trees at eight-minute intervals per tree, at three different times over three days...
February 21, 2024: Insects
https://read.qxmd.com/read/38535300/comparative-metabolomics-of-ligulate-and-tubular-flowers-of-two-cultivars-of-calendula-officinalis-l
#15
JOURNAL ARTICLE
Vladimir Ossipov, Firdaus Khazieva, Dmitry Baleev, Juha-Pekka Salminen, Nikolay Sidelnikov
Calendula officinalis L. is a well-known plant widely used in traditional medicine due to the presence of various biologically active compounds. The main raw material for the production of medicinal preparations is the inflorescence, which consists of ligulate and tubular flowers. However, the characteristics of the metabolome of these flowers are not fully understood. This study identified and compared the levels of major metabolites in the ligulate and tubular flowers of two C. officinalis cultivars, 'Golden Sea' (GS) and 'Paradise Garden' (PG)...
February 26, 2024: Metabolites
https://read.qxmd.com/read/38535110/left-ventricular-diastolic-dysfunction-is-associated-with-poor-functional-outcomes-after-endovascular-thrombectomy
#16
JOURNAL ARTICLE
Tony Y W Li, Emma M S Toh, Ying Ying Koh, Aloysius S T Leow, Bernard P L Chan, Hock-Luen Teoh, Raymond C S Seet, Anil Gopinathan, Cunli Yang, Vijay K Sharma, Leonard L L Yeo, Mark Y Chan, William K F Kong, Kian-Keong Poh, Benjamin Y Q Tan, Ching-Hui Sia
INTRODUCTION: With the advent of endovascular thrombectomy (ET), patients with acute ischaemic strokes (AIS) with large vessel occlusion (LVO) have seen vast improvements in treatment outcomes. Left ventricular diastolic dysfunction (LVDD) has been shown to herald poorer prognosis in conditions such as myocardial infarction. However, whether LVDD is related to functional recovery and outcomes in ischaemic stroke remains unclear. We studied LVDD for possible relation with clinical outcomes in patients with LVO AIS who underwent ET...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535109/atypical-progeria-primarily-manifesting-as-premature-cardiac-valvular-disease-segregates-with-lmna-gene-variants
#17
Hoi W Wu, Ivo P Van de Peppel, Julie W Rutten, J Wouter Jukema, Emmelien Aten, Ingrid M Jazet, Tamara T Koopmann, Daniela Q C M Barge-Schaapveld, Nina Ajmone Marsan
Mutations in the LMNA -gene can cause a variety of 'laminopathies'. These laminopathies are associated with a range of phenotypes, including disorders affecting the adipose tissue, peripheral nerves, the heart, such as dilated cardiomyopathy and conduction system abnormalities, and less commonly, progeroid disorders. This case series describes two families in which two novel LMNA-gene variants were identified, and who presented with an atypical progeroid phenotype with primarily premature aortic and mitral valve stenosis...
March 5, 2024: Journal of Cardiovascular Development and Disease
https://read.qxmd.com/read/38535041/short-and-long-term-chest-ct-findings-after-recovery-from-covid-19-a-systematic-review-and-meta-analysis
#18
REVIEW
Mustufa Babar, Hasan Jamil, Neil Mehta, Ahmed Moutwakil, Tim Q Duong
While ground-glass opacity, consolidation, and fibrosis in the lungs are some of the hallmarks of acute SAR-CoV-2 infection, it remains unclear whether these pulmonary radiological findings would resolve after acute symptoms have subsided. We conducted a systematic review and meta-analysis to evaluate chest computed tomography (CT) abnormalities stratified by COVID-19 disease severity and multiple timepoints post-infection. PubMed/MEDLINE was searched for relevant articles until 23 May 2023. Studies with COVID-19-recovered patients and follow-up chest CT at least 12 months post-infection were included...
March 14, 2024: Diagnostics
https://read.qxmd.com/read/38534744/an-examination-of-the-effects-of-propolis-and-quercetin-in-a-rat-model-of-streptozotocin-induced-diabetic-peripheral-neuropathy
#19
JOURNAL ARTICLE
Sibel Türedi, Hakim Çelik, Şeyda Nur Dağlı, Seyhan Taşkın, Uğur Şeker, Mustafa Deniz
The purpose of this study was to reveal the combined effects of propolis (P) and quercetin (Q) against diabetic peripheral neuropathy developing with streptozotocin-induced diabetes in rats. Sixty-four adult male rats were divided into eight equal groups: control, P (100 mg/kg/day), Q (100 mg/kg/day), P + Q (100 mg/day for both), diabetes mellitus (DM) (single-dose 60 mg/kg streptozotocin), DM + P, DM + Q, and DM + P + Q. The rats were sacrificed, and blood and sciatic nerve tissues were collected. Blood glucose and malondialdehyde (MDA) levels increased, while IL-6 and total antioxidant status decreased in the DM group ( p = 0...
March 2, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534738/effects-of-blood-derived-products-on-cellular-senescence-and-inflammatory-response-a-study-on-skin-rejuvenation
#20
JOURNAL ARTICLE
Harald Kühnel, Markus Pasztorek, Olga Kuten-Pella, Karina Kramer, Christoph Bauer, Zsombor Lacza, Stefan Nehrer
Blood-derived products, such as citrate platelet-rich plasma (CPRP) and hyperacute serum (HAS), are recognized for their rich growth factor content. When human dermal fibroblast (HDF) cells are exposed to combined mitogenic and DNA-damaging stimuli, it can lead to an increased burden of senescent cells and a modified senescence-associated secretory phenotype. In this study, the senescent state was comprehensively assessed through various methods, including phosphorylated histone H2AX (γH2AX) staining, p21 and p16 q-PCR, p21-western blot, growth curves, and senescence-associated ß-galactosidase staining...
February 28, 2024: Current Issues in Molecular Biology
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