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Omid Moshtaghi, Yarah M Haidar, Yaser Ghavami, Jeff Gu, Afsheen Moshtaghi, Ronald Sahyouni, Melissa Huang, Harrison W Lin, Hamid R Djalilian
OBJECTIVES/HYPOTHESIS: To evaluate the variability and discrepancies among the most commonly prescribed ear drops sold at pharmacies in southern California. STUDY DESIGN: Prospective study evaluating 11 commonly used ear drops to treat otologic disorders. METHODS: Randomly selected drug stores in three major counties in Southern California (Los Angeles, Orange, and San Diego) were included. Mean, range, minimum, and maximum prices for each drug were calculated and analyzed...
January 24, 2017: Laryngoscope
Marcelo Pedrosa Gomes, Cíntia Almeida Gonçalves, Júlio César Moreira de Brito, Amanda Miranda Souza, Fernanda Vieira da Silva Cruz, Elisa Monteze Bicalho, Cleber Cunha Figueredo, Queila Souza Garcia
We investigate the physiological responses and antibiotic-uptake capacity of Lemna minor exposed to ciprofloxacin. Ciprofloxacin (Cipro) induced toxic effects and hormesis in plants by significantly modifying photosynthesis and respiration pathways. A toxic effect was induced by a concentration ≥1.05mg ciprofloxacin l(-1) while hormesis occurs at the lowest concentration studied (0.75mg ciprofloxacin l(-1)). By impairing normal electron flow in the respiratory electron transport chain, ciprofloxacin induces hydrogen peroxide (H2O2) production...
January 5, 2017: Journal of Hazardous Materials
Francine C Paim, Stephanie N Langel, David D Fischer, Sukumar Kandasamy, Lulu Shao, Moyasar A Alhamo, Huang-Chi Huang, Anand Kumar, Gireesh Rajashekara, Linda J Saif, Anastasia N Vlasova
We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We analyzed mRNA levels of IEC genes for enteroendocrine cells [chromogranin A (CgA)], goblet cells [mucin 2 (MUC2)], transient amplifying progenitor cell [proliferating cell nuclear antigen (PCNA)], intestinal epithelial stem cell (SOX9) and enterocytes (villin)...
2016: Gut Pathogens
Caio V Z Cipro, Rosalinda C Montone, Paco Bustamante
Mercury (Hg) can reach the environment through natural and human-related sources, threatening ecosystems all over the planet due to its well known deleterious effects. Therefore, Antarctic trophic webs, despite being relatively isolated, are not exempt of its influence. To evaluate Hg concentrations in an Antarctic ecosystem, different tissues from 2 species of invertebrates, 2 of fish, 8 of birds, 4 of pinnipeds and at least 5 of vegetation were investigated (n=176). For animals, values ranged from 0.018 to 48...
January 15, 2017: Marine Pollution Bulletin
Crystal J Jaing, Kevin S McLoughlin, James B Thissen, Adam Zemla, Shea N Gardner, Lisa M Vergez, Feliza Bourguet, Shalini Mabery, Viacheslav Y Fofanov, Heather Koshinsky, Paul J Jackson
Francisella tularensis is classified as a Class A bioterrorism agent by the U.S. government due to its high virulence and the ease with which it can be spread as an aerosol. It is a facultative intracellular pathogen and the causative agent of tularemia. Ciprofloxacin (Cipro) is a broad spectrum antibiotic effective against Gram-positive and Gram-negative bacteria. Increased Cipro resistance in pathogenic microbes is of serious concern when considering options for medical treatment of bacterial infections. Identification of genes and loci that are associated with Ciprofloxacin resistance will help advance the understanding of resistance mechanisms and may, in the future, provide better treatment options for patients...
2016: PloS One
Cyril Stechovsky, Petr Hajek, Simon Cipro, Josef Veselka
Acute coronary syndrome is a common cause of sudden cardiac death. We present a case report of a 60-year-old man without a history of coronary artery disease who presented with ST-elevation myocardial infarction. During transportation to the hospital, he developed ventricular fibrillation (VF) and later pulseless electrical activity. Chest compressions with LUCAS 2 (Medtronic, Minneapolis, MN) automated mechanical compression-decompression device were initiated. Coronary angiography showed total occlusion of the left main coronary artery and primary percutaneous coronary intervention (PCI) was performed...
September 2016: International Journal of Angiology: Official Publication of the International College of Angiology, Inc
Alysson Wagner Fernandes Duarte, Michel Rodrigo Zambrano Passarini, Tiago Palladino Delforno, Franciane Maria Pellizzari, Caio Vinicius Zecchin Cipro, Rosalinda Carmela Montone, Maria Virginia Petry, Jair Putzke, Luiz Henrique Rosa, Lara Durães Sette
Antarctic terrestrial ecosystems are largely dominated by lichens, while shallow coastal environments are mainly covered by macroalgae. The aim of this study was to isolate and to evaluate the diversity of yeasts in different species of macroalgae and lichens collected in South Shetland Islands, Antarctica. A total of 405 yeasts were recovered (205 from macroalgae and 200 from lichens). The yeast community from macroalgae was most diversity than the yeast community from lichen. The dominance index was similar for both substrates...
August 12, 2016: Environmental Microbiology Reports
Hanna Leijoto de Oliveira, Sara da Silva Anacleto, Anny Talita Maria da Silva, Arnaldo César Pereira, Warley de Souza Borges, Eduardo Costa Figueiredo, Keyller Bastos Borges
A simple method using HPLC-DAD was developed for the determination of fluoroquinolones in human urine including ciprofloxacin (CIPRO), enrofloxacino (ENRO), marbofloxacino (MARBO) and norfloxacin (NOR). In addition, it was studied the extraction of fluoroquinolones in human urine samples using pipette tip-based molecularly imprinted polymers solid phase extraction (PT-MIPs-SPE). With the goal of finding the best procedure for extraction of four fluoroquinolones in human urine, several parameters that are likely to affect the efficiency of extraction during sample preparation, including the washing solvent, type and volume of eluent, amount of material, the volume of the sample, pH and the ionic strength were systematically optimized...
October 15, 2016: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
Yaakov Dickstein, Yuval Geffen, Steen Andreassen, Leonard Leibovici, Mical Paul
To improve antibiotic prescribing, we sought to establish the probability of a resistant organism in urine culture given a previous resistant culture in a setting endemic for multidrug-resistant (MDR) organisms. We performed a retrospective analysis of inpatients with paired positive urine cultures. We focused on ciprofloxacin-resistant (cipro(r)) Gram-negative bacteria, extended-spectrum-beta-lactamase (ESBL)-producing Enterobacteriaceae, carbapenem-resistant Enterobacteriaceae (CRE), and carbapenem-resistant nonfermenters (CRNF)...
August 2016: Antimicrobial Agents and Chemotherapy
J A Otero, D García-Mateos, A de la Fuente, J G Prieto, A I Álvarez, G Merino
The ATP-binding cassette transporter G2 (ABCG2) is involved in the secretion of several drugs into milk. The bovine Y581S ABCG2 polymorphism increases the secretion into milk of the fluoroquinolone danofloxacin in Holstein cows. Danofloxacin and enrofloxacin are the fluoroquinolones most widely used in veterinary medicine. Both enrofloxacin (ENRO) and its active metabolite ciprofloxacin (CIPRO) reach milk at relatively high concentrations. The aim of this work was to study the effect of the bovine Y581S ABCG2 polymorphism on in vitro transport as well as on concentrations in plasma and in milk of ENRO and CIPRO...
July 2016: Journal of Dairy Science
Mythili Tummalapalli, Morgane Berthet, Bernard Verrier, B L Deopura, M S Alam, Bhuvanesh Gupta
Biocomposite interactive wound dressings have been designed and fabricated using oxidized pectin (OP), gelatin and nonwoven cotton fabric. Due to their inherent virtues of antimicrobial activity and cytocompatibility, these composite structures are capable of redirecting the healing cascade and influencing cell attachment and proliferation. A novel in situ reduction process has been followed to synthesize oxidized pectin-gelatin-nanosilver (OP-Gel-NS) flower like nanohydrocolloids. This encapsulation technology controls the diffusion and permeation of nanosilver into the surrounding biological tissues...
May 30, 2016: International Journal of Pharmaceutics
Katja Dralle Mjos, Elena Polishchuk, Michael J Abrams, Chris Orvig
The antimicrobial properties of copper have been known to mankind since the ancient times. In a coordination chemistry approach to develop novel antimicrobial agents, the quinolone antimicrobial agents ciprofloxacin (Hcipro) and pipemidic acid (Hpia), as well as dimers thereof (piperazinyl-linked with a p-xylenyl moiety) were complexed with copper(II). The synthesis and antimicrobial evaluation of bis(ciprofloxacino)copper(II) [Cu(cipro)2], bis(pipemido)copper(II) [Cu(pia)2], and the corresponding dimer complexes, [Cu2(ciproXcipro)2] and [Cu2(piaXpia)2], are reported...
February 27, 2016: Journal of Inorganic Biochemistry
Rosalinda C Montone, Satie Taniguchi, Fernanda I Colabuono, César C Martins, Caio Vinícius Z Cipro, Hileia S Barroso, Josilene da Silva, Márcia C Bícego, Rolf R Weber
Persistent organic pollutants were assessed in fat samples of the Gentoo (Pygoscelis papua), Chinstrap (Pygoscelis antarcticus) and Adélie (Pygoscelis adeliae) penguins collected during the austral summers of 2005/06 and 2006/07 in Admiralty Bay, King George Island, Antarctica. The predominant organic pollutants were PCB (114 to 1115), polycyclic aromatic hydrocarbons (PAHs) (60.1 to 238.7), HCB (<0.3 to 132.2) and BDE-47 (<1.0 to 10.7) in ng g(-1) wet weight. The mean concentrations of the majority of organic pollutants were similar among the three species of penguins...
May 15, 2016: Marine Pollution Bulletin
Maryam Shayani Rad, Seyed Ahmad Mohajeri
OBJECTIVES: Ciprofloxacin (Cipro) is an antibiotic, widely used in form of ophthalmic drops (0.3%) for the treatment of eye infections. In this study, vitamin E was used as a hydrophobic barrier to improve and prolong the amount and time of Cipro release from silicone-based soft contact lenses. METHODS: Three different commercial contact lenses (Air Optix, Biofinity, and Acuvue Oasys) were soaked in vitamin E solutions (0.1 and 0.2 g/mL). The effect of vitamin E on Cipro loading amount and drug releasing profile was evaluated in artificial tear...
February 9, 2016: Eye & Contact Lens
Maryam Shayani Rad, Seyed Ahmad Mohajeri
PURPOSE: The purpose of the present study was to evaluate the efficacy of commercial soft contact lenses, loaded with vitamin E, as ocular drug delivery systems for simultaneous loading and release of ciprofloxacin (Cipro) and betamethasone (BMZ) in artificial tears. METHODS: In this study, we applied vitamin E as a barrier to increase BMZ-Cipro loading into three commercial silicone-based soft contact lenses and control their simultaneous release into the artificial lachrymal fluid...
September 2016: Current Eye Research
A M El-Kosasy, Omar Abdel-Aziz, N Magdy, N M El Zahar
New accurate, sensitive and selective spectrophotometric and chemometric methods were developed and subsequently validated for determination of Imipenem (IMP), ciprofloxacin hydrochloride (CIPRO), dexamethasone sodium phosphate (DEX), paracetamol (PAR) and cilastatin sodium (CIL) in human urine. These methods include a new derivative ratio method, namely extended derivative ratio (EDR), principal component regression (PCR) and partial least-squares (PLS) methods. A novel EDR method was developed for the determination of these drugs, where each component in the mixture was determined by using a mixture of the other four components as divisor...
March 15, 2016: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
H M H N Bandara, D Nguyen, S Mogarala, M Osiñski, H D C Smyth
Due to the refractory nature of pathogenic microbial biofilms, innovative biofilm eradication strategies are constantly being sought. Thus, this study addresses a novel approach to eradicate Pseudomonas aeruginosa biofilms. Magnetic nanoparticles (MNP), ciprofloxacin (Cipro), and magnetic fields were systematically evaluated in vitro for their relative anti-biofilm contributions. Twenty-four-hour biofilms exposed to aerosolized MNPs, Cipro, or a combination of both, were assessed in the presence or absence of magnetic fields (Static one-sided, Static switched, Oscillating, Static + oscillating) using changes in bacterial metabolism, biofilm biomass, and biofilm imaging...
2015: Biofouling
Erica S Martins-Duarte, Faustine Dubar, Philippe Lawton, Cristiane França da Silva, Maria de Nazaré C Soeiro, Wanderley de Souza, Christophe Biot, Rossiane C Vommaro
Toxoplasmosis, caused by the protozoan Toxoplasma gondii, is a worldwide disease whose clinical manifestations include encephalitis and congenital malformations in newborns. Previously, we described the synthesis of new ethyl-ester derivatives of the antibiotic ciprofloxacin with ~40-fold increased activity against T. gondii in vitro, compared with the original compound. Cipro derivatives are expected to target the parasite's DNA gyrase complex in the apicoplast. The activity of these compounds in vivo, as well as their mode of action, remained thus far uncharacterized...
2015: PloS One
Jay Seidel, Terry Clarke, Bindu Mathew
Ciprofloxacin and other fluoroquinolones are commonly used broad-spectrum antimicrobial agents for treating bacterial infections. This class of antibiotic drugs has uncommon adverse effects that include tendonitis, tendon ruptures, and other tendon abnormalities. We describe a patient with spontaneous bilateral complete Achilles tendon rupture after ciprofloxacin treatment. Surgical repair was performed successfully, and the patient completed physical rehabilitation without incident. Care should be exercised when selecting pharmaceutical agents to maintain a positive benefit-to-risk balance...
March 2015: Journal of the American Podiatric Medical Association
Fernanda Imperatrice Colabuono, Satie Taniguchi, Caio Vinícius Zecchin Cipro, Josilene da Silva, Márcia Caruso Bícego, Rosalinda Carmela Montone
A fire at the Brazilian Antarctic Station on February 25th, 2012 led to the burning of material that produced organic pollutants. To evaluate the impact in the surrounding area, polycyclic aromatic hydrocarbons (PAHs) and persistent organic pollutants (POPs) were analyzed in moss samples collected in the vicinities of the station before and after the incident and compared to findings from previous studies in the same region. PCBs were on the same magnitude as that reported in previous studies, which could be associated to the global dispersion of these compounds and may not be related to the local fire...
April 15, 2015: Marine Pollution Bulletin
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