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https://www.readbyqxmd.com/read/28483402/doxycycline-for-outpatient-treated-acute-exacerbations-of-copd-a-randomised-double-blind-placebo-controlled-trial
#1
Patricia van Velzen, Gerben Ter Riet, Paul Bresser, Jeroen J Baars, Bob T J van den Berg, Jan W K van den Berg, Paul Brinkman, Jennece W F Dagelet, Johannes M A Daniels, Dewi R G L Groeneveld-Tjiong, René E Jonkers, Coen van Kan, Frans H Krouwels, Karin Pool, Arjan Rudolphus, Peter J Sterk, Jan M Prins
BACKGROUND: Antibiotics do not reduce mortality or short-term treatment non-response in patients receiving treatment for acute exacerbations of COPD in an outpatient setting. However, the long-term effects of antibiotics are unknown. The aim of this study was to investigate if the antibiotic doxycycline added to the oral corticosteroid prednisolone prolongs time to next exacerbation in patients with COPD receiving treatment for an exacerbation in the outpatient setting. METHODS: In this randomised double-blind placebo-controlled trial, we recruited a cohort of patients with COPD from outpatient clinics of nine teaching hospitals and three primary care centres in the Netherlands...
May 5, 2017: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/28418334/juvenile-idiopathic-arthritis
#2
Kenan Barut, Amra Adrovic, Sezgin Şahin, Özgür Kasapçopur
Juvenile idiopathic arthritis is the most common chronic rheumatic disease of unknown aetiology in childhood and predominantly presents with peripheral arthritis. The disease is divided into several subgroups, according to demographic characteristics, clinical features, treatment modalities and disease prognosis. Systemic juvenile idiopathic arthritis, which is one of the most frequent disease subtypes, is characterized by recurrent fever and rash. Oligoarticular juvenile idiopathic arthritis, common among young female patients, is usually accompanied by anti-nuclear antibodie positivity and anterior uveitis...
April 5, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28290161/corticosteroids-for-tuberculous-pleurisy
#3
REVIEW
Hannah Ryan, Jinho Yoo, Padmapriya Darsini
BACKGROUND: Corticosteroids used in addition to antituberculous therapy have been reported to benefit people with tuberculous pleurisy. However, research findings are inconsistent and raise doubt as to whether such treatment is worthwhile. There is also concern regarding the potential adverse effects of corticosteroids, especially in HIV-positive people. OBJECTIVES: To evaluate the effects of adding corticosteroids to drug regimens for tuberculous pleural effusion...
March 14, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28130929/use-of-antenatal-corticosteroids-in-special-circumstances-a-comprehensive-review
#4
REVIEW
Everett F Magann, Kjell Haram, Songthip Ounpraseuth, Jan H Mortensen, Horace J Spencer, John C Morrison
The aim of this study was to determine, in pregnancies complicated by preterm premature rupture of membranes (PPROM), hypertension, intrauterine growth restriction, multi-fetal gestations and pregnancies 23-26 weeks and ≥34 weeks' gestation, whether antenatal corticosteroids benefit the fetus. Literature review using PubMed, Web of Science, Clinical trials.gov, Cochrane Database of Systematic Reviews (1990-2015). Search terms linked special circumstances with corticosteroids. Randomized clinical trials, retrospective and prospective cohort studies, and case control studies were reviewed...
April 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28099820/new-and-developing-non-adrenoreceptor-small-molecule-drugs-for-the-treatment-of-asthma
#5
REVIEW
Neil C Thomson
Inhaled corticosteroids (ICS) alone or in combination with an inhaled long-acting beta2-agonist (LABA) are the preferred long-term treatment for adults and adolescents with symptomatic asthma. Additional drugs include leukotriene-receptor antagonists, slow-release theophylline and the long-acting muscarinic antagonist (LAMA) tiotropium (approved in 2015). There is a need for more effective therapies, as many patients continue to have poorly controlled asthma. Areas covered: New and developing long-acting non-adrenoreceptor synthetic drugs for the treatment of symptomatic chronic asthma despite treatment with an ICS alone or combined with a LABA...
February 2017: Expert Opinion on Pharmacotherapy
https://www.readbyqxmd.com/read/28025775/systemic-treatment-of-adult-atopic-dermatitis-a-review
#6
REVIEW
Matteo Megna, Maddalena Napolitano, Cataldo Patruno, Alessia Villani, Anna Balato, Giuseppe Monfrecola, Fabio Ayala, Nicola Balato
Atopic dermatitis (AD) is a common chronic inflammatory skin disease that predominantly affects children. However, it can persist in adulthood and/or start at older ages. Due to its chronic nature and frequently occurring relapses, AD has a substantial effect on patients' quality of life, often requiring long-term systemic treatment, especially in adult patients, who are more frequently refractory to adequate topical treatment with mid- to high-potent corticosteroids and/or calcineurin inhibitors. Therefore, treatment with systemic therapies is often needed to take control of the disease, prevent exacerbations and improve quality of life...
March 2017: Dermatology and Therapy
https://www.readbyqxmd.com/read/27923549/assessing-the-value-of-mepolizumab-for-severe-eosinophilic-asthma-a-cost-effectiveness-analysis
#7
Melanie D Whittington, R Brett McQueen, Daniel A Ollendorf, Jeffrey A Tice, Richard H Chapman, Steven D Pearson, Jonathan D Campbell
BACKGROUND: Adding mepolizumab to standard treatment with inhaled corticosteroids and controller medications could decrease asthma exacerbations and use of long-term oral steroids in patients with severe disease and increased eosinophils; however, mepolizumab is costly and its cost effectiveness is unknown. OBJECTIVE: To estimate the cost effectiveness of mepolizumab. METHODS: A Markov model was used to determine the incremental cost per quality-adjusted life year (QALY) gained for mepolizumab plus standard of care (SoC) and for SoC alone...
February 2017: Annals of Allergy, Asthma & Immunology
https://www.readbyqxmd.com/read/27302143/effect-of-sodium-hyluronate-added-to-topical-corticosteroids-in-chronic-rhinosinusitis-with-nasal-polyposis
#8
E Cantone, M Iengo
BACKGROUND: Available medical treatments for chronic rhinosinusitis (CRS) with nasal polyposis (CRSwNP) comprise systemic and topical therapies. Although topical corticosteroids are effective in the treatment of CRS, they are not completely devoid of adverse effects. Thus, care has to be taken when long-term treatments are prescribed. There is recent evidence that sodium hyaluronate (SH), the major component of many extracellular matrices, promotes tissue healing, including activation and moderation of the inflammatory responses, cell proliferation, migration, and angiogenesis...
June 2, 2016: American Journal of Rhinology & Allergy
https://www.readbyqxmd.com/read/27271488/long-term-safety-and-efficacy-of-low-dose-azathioprine-and-allopurinol-cotherapy-in-inflammatory-bowel-disease-a-large-observational-study
#9
Polychronis Pavlidis, Panagiotis Stamoulos, Answar Abdulrehman, Patrick Kerr, Claire Bull, John Duley, Azhar Ansari
BACKGROUND: Low-dose azathioprine with allopurinol (LDAA) has been proposed as a potent therapy in inflammatory bowel disease (IBD) with the benefit of overcoming side effects regularly associated with thiopurine monotherapy and poor responses. Concerns regarding safety remain, while a layer of complexity has been added by the trend toward treatment directed by red cell thioguanine nucleotide (TGN) profiling. We report on the clinical efficacy and safety of LDAA use in IBD undirected by metabolite profiling...
July 2016: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/27267134/systematic-review-of-published-trials-long-term-safety-of-topical-corticosteroids-and-topical-calcineurin-inhibitors-in-pediatric-patients-with-atopic-dermatitis
#10
Elaine C Siegfried, Jennifer C Jaworski, Jennifer D Kaiser, Adelaide A Hebert
BACKGROUND: Many clinicians have concerns about the safety of atopic dermatitis (AD) treatments, particularly in children requiring long-term daily maintenance therapy. Topical corticosteroids (TCS) have been widely used for >5 decades. Long-term TCS monotherapy has been associated with adverse cutaneous effects including atrophy, rebound flares, and increased percutaneous absorption with potential for adverse systemic effects. Topical calcineurin inhibitors (TCIs), tacrolimus and pimecrolimus, available for 1-2 decades, are not associated with atrophy or increased percutaneous absorption after prolonged use and have much lower potential for systemic effects...
June 7, 2016: BMC Pediatrics
https://www.readbyqxmd.com/read/27165566/addressing-treatment-challenges-in-atopic-dermatitis-with-novel-topical-therapies
#11
REVIEW
Jonathan I Silverberg, Diane B Nelson, Gil Yosipovitch
Atopic dermatitis (AD), a chronic inflammatory skin disease affecting children and adults, presents as mild-to-moderate disease in the majority of patients. Pruritus, one of the key diagnostic criteria for AD, is associated with reduced quality of life and disease aggravation. Current treatments include emollients and topical pharmaceutical agents. Topical corticosteroids (TCSs) are commonly used, but are associated with safety concerns with cutaneous and systemic side effects. Topical calcineurin inhibitors (TCIs) inhibit T-lymphocyte activation, but their use is limited because of application-site infections and a boxed warning for potential malignancy risk...
November 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/26386912/the-effectiveness-of-soft-tissue-therapy-for-the-management-of-musculoskeletal-disorders-and-injuries-of-the-upper-and-lower-extremities-a-systematic-review-by-the-ontario-protocol-for-traffic-injury-management-optima-collaboration
#12
REVIEW
Steven Piper, Heather M Shearer, Pierre Côté, Jessica J Wong, Hainan Yu, Sharanya Varatharajan, Danielle Southerst, Kristi A Randhawa, Deborah A Sutton, Maja Stupar, Margareta C Nordin, Silvano A Mior, Gabrielle M van der Velde, Anne L Taylor-Vaisey
BACKGROUND: Soft-tissue therapy is commonly used to manage musculoskeletal injuries. OBJECTIVE: To determine the effectiveness of soft-tissue therapy for the management of musculoskeletal disorders and injuries of the upper and lower extremities. DESIGN: Systematic Review. METHODS: We searched six databases from 1990 to 2015 and critically appraised eligible articles using Scottish Intercollegiate Guidelines Network (SIGN) criteria...
February 2016: Manual Therapy
https://www.readbyqxmd.com/read/26343420/withdrawn-antiviral-treatment-for-bell-s-palsy-idiopathic-facial-paralysis
#13
REVIEW
Ildiko Gagyor, Vishnu B Madhok, Fergus Daly, Dhruvashree Somasundara, Michael Sullivan, Fiona Gammie, Frank Sullivan
No abstract text is available yet for this article.
September 7, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26302738/steroid-sparing-effect-of-omalizumab-in-seropositive-allergic-bronchopulmonary-aspergillosis
#14
Keith T Beam, Christopher A Coop
BACKGROUND: Allergic bronchopulmonary aspergillosis (ABPA) is a common serious hypersensitivity reaction to airway colonization with Aspergillus in patients with asthma or cystic fibrosis. While steroids are effective in controlling the respiratory symptoms of ABPA, they have many side effects that make them undesirable for long term use. Antifungals have been used to reduce dependency on systemic steroids but long term use can be limited by side effects and there is the possibility of developing resistance to azoles...
January 2015: Allergy & Rhinology
https://www.readbyqxmd.com/read/26301488/long-acting-muscarinic-antagonists-lama-added-to-inhaled-corticosteroids-ics-versus-the-same-dose-of-ics-alone-for-adults-with-asthma
#15
REVIEW
Debbie E Anderson, Kayleigh M Kew, Anne C Boyter
BACKGROUND: Despite the availability of several evidence-based therapies and non-pharmacological strategies to improve control of symptoms and prevent exacerbations of asthma, patients with asthma continue to be at risk for mortality and morbidity.Previous trials have demonstrated the potentially beneficial effects of the long-acting muscarinic antagonist (LAMA) tiotropium on lung function in patients with asthma; however, a definitive conclusion on the benefit of LAMA in asthma is lacking, as is information on where in the current step-wise management strategy they would be most beneficial...
August 24, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26130372/antiviral-treatment-for-bell-s-palsy-idiopathic-facial-paralysis
#16
REVIEW
Ildiko Gagyor, Vishnu B Madhok, Fergus Daly, Dhruvashree Somasundara, Michael Sullivan, Fiona Gammie, Frank Sullivan
BACKGROUND: Corticosteroids are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but the effectiveness of additional treatment with an antiviral agent is uncertain. Significant morbidity can be associated with severe cases of Bell's palsy. OBJECTIVES: To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell's palsy. SEARCH METHODS: On 7 October 2014 we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE, EMBASE, LILACS, DARE, NHS EED, and HTA...
July 1, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26031392/long-acting-muscarinic-antagonists-lama-added-to-inhaled-corticosteroids-ics-versus-addition-of-long-acting-beta2-agonists-laba-for-adults-with-asthma
#17
REVIEW
Kayleigh M Kew, David J W Evans, Debbie E Allison, Anne C Boyter
BACKGROUND: Poorly controlled asthma and preventable exacerbations place a significant strain on healthcare, often requiring additional medications, hospital stays or treatment in the emergency department.Long-acting beta2-agonists (LABA) are the preferred add-on treatment for adults with asthma whose symptoms are not well controlled on inhaled corticosteroids (ICS), but have important safety concerns in asthma. Long-acting muscarinic antagonists (LAMA) have confirmed efficacy in chronic obstructive pulmonary disease and are now being considered as an alternative add-on therapy for people with uncontrolled asthma...
June 2, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26028863/a-prospective-randomized-double-blind-placebo-controlled-clinical-trial-comparing-the-efficacy-of-anti-edema-drugs-for-edema-control-in-orthognathic-surgery-using-digitizer-3-d-to-measure-facial-swelling
#18
U Tozzi, V Santillo, G P Tartaro, A Sellitto, G R Gravino, M Santagata
INTRODUCTION: Orthognathic surgery involves making several osteotomies. Any osteotomies leads to varying degrees of post-operative swelling. The aim of this study was to evaluate the effectiveness of anti-edema drugs for the control of edema, using Digitizer 3D™ for measuring soft-tissue thickness, in patients who underwent bimaxillaryorthognathic surgery. MATERIALS AND METHODS: In this double-blinded, randomized, control trial, 24 patients (study group: 12 patients, control group: 12 patients) in whom bimaxillary orthognathic surgery was indicated, were included in this study...
June 2015: Journal of Maxillofacial and Oral Surgery
https://www.readbyqxmd.com/read/25938618/withdrawn-antiviral-treatment-for-bell-s-palsy-idiopathic-facial-paralysis
#19
REVIEW
Ildiko Gagyor, Vishnu B Madhok, Fergus Daly, Dhruvashree Somasundara, Michael Sullivan, Fiona Gammie, Frank Sullivan
BACKGROUND: Corticosteroids are widely used in the treatment of idiopathic facial paralysis (Bell's palsy), but the effectiveness of additional treatment with an antiviral agent is uncertain. Significant morbidity can be associated with severe cases of Bell's palsy. OBJECTIVES: To assess the effects of antiviral treatments alone or in combination with any other therapy for Bell's palsy. SEARCH METHODS: On 7 October 2014 we searched the Cochrane Neuromuscular Disease Group Specialized Register, CENTRAL, MEDLINE, EMBASE, LILACS, DARE, NHS EED, and HTA...
May 4, 2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25889129/systemic-therapy-of-childhood-atopic-dermatitis
#20
REVIEW
Nathaniel A Slater, Dean S Morrell
Atopic dermatitis (AD) is a common childhood inflammatory disease that, in a small percentage of cases, can become severe enough to require potent systemic treatment. Many trials have been conducted with systemic agents for the treatment of severe pediatric AD; we review the evidence here. Although corticosteroids are widely used in practice, they are not generally recommended as a systemic treatment option for AD in children. Most patients experience a relatively rapid and robust response to cyclosporine. Treating children with cyclosporine long term is troubling; however, azathioprine, mycophenolate mofetil, and methotrexate are all reasonable alternatives for maintenance therapy in recalcitrant cases...
May 2015: Clinics in Dermatology
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