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https://www.readbyqxmd.com/read/29451225/quality-of-life-among-adolescents-aged-14-to-18-years-with-beta-thalassemia-major-tm-in-qatar
#1
Abdulqadir J Nashwan, Mohamed A Yassin, Ganga Devi J Babu, Sindhumole L K Nair, Izette L Libo-On, Hothaifah A Hijazi, Vincenzo De Sanctis, Ashraf Soliman
BACKGROUND: Thalassemia is a heterogeneous group of inherited disorders of hemoglobin synthesis. It is a common disease in Mediterranean, Southeast Asia, Indian subcontinent, and Middle East countries, including Qatar. PURPOSE: The aim of this study was to assess the quality of life (QOL) among patients aged 14 to 18 years with thalassemia major (TM) in Qatar and correlates their QOL with bio-demographic data of the patients compared to healthy controls. MATERIALS AND METHODS: This cross-sectional study measured the QOL in adolescents with thalassemia major who were attending ambulatory units in a tertiary hospital in Qatar...
February 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29450669/association-of-tert-clptm1l-and-8q24-common-genetic-variants-with-gallbladder-cancer-susceptibility-and-prognosis-in-north-indian-population
#2
Saurabh Yadav, Abhijit Chandra, Ashok Kumar, Balraj Mittal
Gallbladder carcinoma (GBC) is one of the common malignancy of the biliary tract. Several genome wide and candidate gene studies have reported associations between multiple cancer types and single-nucleotide polymorphisms on 5p15.33 and 8q24.21 loci. However, predisposition potential of these genetic variants has not been assessed in GBC. We performed the present study to assess the potential of five polymorphisms on 5p15.33 and one on 8q24.21 locus in GBC risk and treatment response in patients undergoing chemoradiotherapy...
February 15, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29450636/comparing-the-efficacy-of-low-dose-vs-high-dose-cyclophosphamide-regimen-as-induction-therapy-in-the-treatment-of-proliferative-lupus-nephritis-a-single-center-study
#3
Sonal Mehra, Jignesh B Usdadiya, Vikramraj K Jain, Durga Prasanna Misra, Vir Singh Negi
Cyclophosphamide (CYC) has been the backbone immunosuppressive drug to achieve sustained remission in lupus nephritis (LN). The aim was to evaluate the efficacy and compare adverse effects of low and high dose intravenous CYC therapy in Indian patients with proliferative lupus nephritis. An open-label, parallel group, randomized controlled trial involving 75 patients with class III/IV LN was conducted after obtaining informed consent. The low dose group (n = 38) received 6 × 500 mg CYC fortnightly and high dose group (n = 37) received 6 × 750 mg/m 2 CYC four-weekly followed by azathioprine...
February 15, 2018: Rheumatology International
https://www.readbyqxmd.com/read/29450524/effect-of-a-quality-improvement-intervention-on-clinical-outcomes-in-patients-in-india-with-acute-myocardial-infarction-the-acs-quik-randomized-clinical-trial
#4
Mark D Huffman, Padinhare P Mohanan, Raji Devarajan, Abigail S Baldridge, Dimple Kondal, Lihui Zhao, Mumtaj Ali, Mangalath N Krishnan, Syam Natesan, Rajesh Gopinath, Sunitha Viswanathan, Joseph Stigi, Johny Joseph, Somanathan Chozhakkat, Donald M Lloyd-Jones, Dorairaj Prabhakaran
Importance: Wide heterogeneity exists in acute myocardial infarction treatment and outcomes in India. Objective: To evaluate the effect of a locally adapted quality improvement tool kit on clinical outcomes and process measures in Kerala, a southern Indian state. Design, Setting, and Participants: Cluster randomized, stepped-wedge clinical trial conducted between November 10, 2014, and November 9, 2016, in 63 hospitals in Kerala, India, with a last date of follow-up of December 31, 2016...
February 13, 2018: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/29449347/association-of-tumor-necrosis-factor-%C3%AE-tnf-%C3%AE-gene-promoter-polymorphisms-with-aggressive-and-chronic-periodontitis-in-eastern-indian-population
#5
Poulami Majumder, Keheibamding Thou, Mandar Bhattacharya, Vineet Nair, Sujay Ghosh, Subrata Kumar Dey
Periodontitis is a very common inflammatory oral disease. Tumor necrosis factor α (TNF-α), a cytokine has been involved with the gingival tissue destruction and remodeling occurrence. We aimed at investigation of the association of single nucleotide polymorphisms (SNPs) in TNF-α gene promoter region to the susceptibility of aggressive and chronic periodontitis in eastern Indian population. A total of 397 DNA samples from venous blood have been isolated, among them 40 individuals were aggressive periodontitis patient, 157 were identified chronic periodontitis patients and remaining 200 were healthy individuals...
February 15, 2018: Bioscience Reports
https://www.readbyqxmd.com/read/29449159/agenesis-functional-deficiency-and-the-common-type-of-the-flexor-digitorum-superficialis-of-the-little-finger-a-meta-analysis
#6
K Yammine, M Erić
Agenesis, functional deficiency and the common type of the flexor digitorum superficialis of the little finger are reported in the literature to be highly variable with significant discrepancy between clinical and cadaveric frequencies. The aim of this systematic review was to generate overall clinical and cadaveric weighted frequencies, along with ancestry-based, side-based, sex-based and laterality-based frequencies. A systematic literature search identified 34 studies including 12,213 forearms/hands that met the inclusion criteria...
February 12, 2018: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/29449100/hepatitis-a-vaccination-coverage-among-adolescents-13-17-years-in-the-united-states-2008-2016
#7
Noele P Nelson, David Yankey, James A Singleton, Laurie D Elam-Evans
BACKGROUND: The hepatitis A (HepA) vaccine was recommended by the Advisory Committee on Immunization Practices (ACIP) incrementally from 1996 to 1999. In 2006, HepA vaccine was recommended (1) universally for children aged 12-23 months, (2) for persons who are at increased risk for infection, or (3) for any person wishing to obtain immunity. Catch-up vaccination can be considered. OBJECTIVE: To assess HepA vaccine coverage among adolescents and factors independently associated with vaccination administration in the US...
February 12, 2018: Vaccine
https://www.readbyqxmd.com/read/29447948/roles-of-ihh-signaling-in-chondroprogenitor-function-in-postnatal-condylar-cartilage
#8
Naito Kurio, Cheri Saunders, Till E Bechtold, Imad Salhab, Hyun-Duck Nah, Sayantani Sinha, Paul C Billings, Maurizio Pacifici, Eiki Koyama
Condylar articular cartilage in mouse temporomandibular joint develops from progenitor cells near the articulating surface that proliferate, undergo chondrogenesis and mature into hypertrophic chondrocytes. However, it remains unclear how these processes are regulated, particularly postnatally. Here we focused on the apical polymorphic layer rich in progenitors and asked whether the phenotype and fate of the cells require signaling by Indian hedgehog (Ihh) previously studied in developing long bones. In condyles in newborn mice, the apical polymorphic/progenitor cell layer was ~10 cell layer-thick and expressed the articular matrix marker Tenascin-C (Tn-C), and the underlying thick cell layer expressed Tn-C as well as the chondrogenic master regulator Sox9...
February 12, 2018: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/29446825/phytomedicines-medicines-derived-from-plants-for-sickle-cell-disease
#9
REVIEW
Oluseyi Oniyangi, Damian H Cohall
BACKGROUND: Sickle cell disease, a common recessively inherited haemoglobin disorder, affects people from sub-Saharan Africa, the Middle East, Mediterranean basin, Indian subcontinent, Caribbean and South America. It is associated with complications and a reduced life expectancy. Phytomedicines (medicine derived from plants in their original state) encompass many of the plant remedies from traditional healers which the populations most affected would encounter. Laboratory research and limited clinical trials have suggested positive effects of phytomedicines both in vivo and in vitro...
February 15, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29446543/cyclin-dependent-kinase-inhibitor-2a-b-gene-deletions-are-markers-of-poor-prognosis-in-indian-children-with-acute-lymphoblastic-leukemia
#10
Manisha Agarwal, Sameer Bakhshi, Sadanand N Dwivedi, Madhulika Kabra, Rashmi Shukla, Rachna Seth
BACKGROUND: Cyclin dependent kinase inhibitor 2A/B (CDKN2A/B) genes are implicated in many malignancies including acute lymphoblastic leukemia (ALL). These tumor suppressor genes, with a key regulatory role in cell cycle are located on chromosome 9p21.3. Previous studies involving CDKN2A/B gene deletions have shown mixed associations with survival outcome in childhood ALL. PROCEDURE: Hundred and four newly diagnosed children with ALL (1-14 years) were enrolled in this study...
February 15, 2018: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/29446340/identification-of-vitamin-b12-deficiency-in-vegetarian-indians
#11
Sadanand Naik, Namita Mahalle, Vijayshri Bhide
The prevalence of a sub-clinical vitamin B12 deficiency in the vegetarians is high. Total serum vitamin B12 concentration alone does not reliably reflect vitamin B12 status. Holotranscobalamin (holo-TC) II is a bioactive B12 fraction promoting specific uptake of B12 by cells and the circulating concentration reflects the intake of B12, whereas total homocysteine (tHcy) indicates the metabolic ability. In this study, we investigated the diagnostic value of circulating holo-TC, B12, folate and homocysteine in vegetarians who were at risk of B12 deficiency...
February 15, 2018: British Journal of Nutrition
https://www.readbyqxmd.com/read/29446214/new-developments-in-india-concerning-the-policy-of-passive-euthanasia
#12
Scaria Kanniyakonil
Euthanasia and assisted dying are illegal in India according to Sections 306 and 309 of the Indian Penal Code (IPC), and Article 21 of the Constitution of India. There have been a number of cases where the Indian High Courts and Indian Supreme Court issued differing verdicts concerning the right to life and the right to die. Nevertheless, on 7 March 2011, a paradigm shift happened as a result of the Indian Supreme Court's judgment on involuntary passive euthanasia in the case of Aruna Shanbaug. In its judgment, the Supreme Court requested the government to prepare a law on euthanasia...
February 15, 2018: Developing World Bioethics
https://www.readbyqxmd.com/read/29446018/green-synthesis-of-silver-nanoparticles-using-piper-nigrum-tissue-specific-bioaccumulation-histopathology-and-oxidative-stress-responses-in-indian-major-carp-labeo-rohita
#13
Chellappan Shobana, Basuvannan Rangasamy, Rama Krishnan Poopal, Sivashankar Renuka, Mathan Ramesh
The aim of the present investigation is to assess the sublethal toxicity of biologically synthesized silver nanoparticles (Ag NPs) in Indian major carp Labeo rohita. Ag NPs used in the study were synthesized by using AgNO 3 with aqueous leaf extract of Piper nigrum. Median lethal concentration (LC 50 ) of synthesized Ag NPs was determined for 96 h (25 μg/L); 2.5 μg/L (1/10th LC 50 ) and 5 μg/L (1/5th LC 50 ) were taken as sublethal concentrations to evaluate the toxicity for 35 days. The results of the TEM, SEM, and EDX analyses revealed that Ag NPs were considerably accumulated in the gill, liver, and kidney of fish at both concentrations (2...
February 14, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29445940/differences-in-breast-cancer-incidence-among-young-women-aged-20-49-years-by-stage-and-tumor-characteristics-age-race-and-ethnicity-2004-2013
#14
Meredith L Shoemaker, Mary C White, Manxia Wu, Hannah K Weir, Isabelle Romieu
PURPOSE: Younger women diagnosed with breast cancer have poorer prognoses and higher mortality compared to older women. Young black women have higher incidence rates of breast cancer and more aggressive subtypes than women of other races/ethnicities. In this study, we examined recent trends and variations in breast cancer incidence among young women in the United States. METHODS: Using 2004-2013 National Program of Cancer Registries and Surveillance, Epidemiology, and End Results Program data, we calculated breast cancer incidence rates and trends and examined variations in stage, grade, and tumor subtype by age and race/ethnicity among young women aged 20-49 years...
February 14, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29445774/an-evaluation-of-immunization-services-using-the-reaching-every-district-criteria-in-two-districts-of-gujarat-india
#15
J P Montgomery, P Ganguly, B F Carlson, N Shrivastwa, M L Boulton
Background: Immunizations are considered the most successful and cost-effective public health interventions employed today. While immunization coverage in India has improved dramatically in the last decade, areas of very low coverage persist. The University of Michigan School of Public Health and the Indian Institute of Public Health Gandhinagar collaborated to document strengths and weaknesses of immunization service delivery in two districts in India. Methods: This report describes a qualitative assessment of clinic level immunization service delivery in ten primary health centers (PHCs) located in two districts of Gujarat, India...
2018: Global Health Research and Policy
https://www.readbyqxmd.com/read/29445423/an-update-on-vitamin-b12-related-gene-polymorphisms-and-b12-status
#16
REVIEW
S Surendran, A Adaikalakoteswari, P Saravanan, I A Shatwaan, J A Lovegrove, K S Vimaleswaran
Background: Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vitamin B12 status is poorly understood. However, advancements in genomic techniques have increased the knowledge-base of the genetics of vitamin B12 status. Based on the candidate gene and genome-wide association (GWA) studies, associations between genetic loci in several genes involved in vitamin B12 metabolism have been identified...
2018: Genes & Nutrition
https://www.readbyqxmd.com/read/29444674/the-gendered-experience-with-respect-to-health-seeking-behaviour-in-an-urban-slum-of-kolkata-india
#17
Moumita Das, Federica Angeli, Anja J S M Krumeich, Onno C P van Schayck
BACKGROUND: Empirical evidence shows that the relationship between health-seeking behaviour and diverse gender elements, such as gendered social status, social control, ideology, gender process, marital status and procreative status, changes across settings. Given the high relevance of social settings, this paper intends to explore how gender elements interact with health-seeking practices among men and women residing in an Indian urban slum, in consideration of the unique socio-cultural context that characterises India's slums...
February 14, 2018: International Journal for Equity in Health
https://www.readbyqxmd.com/read/29442088/morphological-and-morphometric-analysis-of-accessory-mental-foramen-in-dry-human-mandibles-of-south-indian-population
#18
J Rajkohila, Priyanka Daniel, Sakunthala Ambikaipakan, Suganthy Rabi
Background: Mental foramen (MF) is an important landmark for administration of local anesthesia in surgical procedures involving the mandible. Additional mental foramina, called accessory mental foramina (AMF) transmitting branches of mental nerve, have been reported. Detection of AMFs in presurgical imaging may reduce postoperative pain in dental surgical procedures. Aim: The aim of the study was to study the incidence and morphometric analysis of accessory MF in the dry human mandibles of South Indian population...
January 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29441306/idiopathic-eruptive-macular-pigmentation-in-an-indian-male
#19
Rajiv Joshi
No abstract text is available yet for this article.
January 2018: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/29441290/indian-dermatology-online-journal-idoj-going-the-print-way
#20
EDITORIAL
Sunil Dogra
No abstract text is available yet for this article.
January 2018: Indian Dermatology Online Journal
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