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https://www.readbyqxmd.com/read/29668120/cytomegalovirus-infection-in-living-donor-liver-transplant-recipients-significantly-impacts-the-early-post-transplant-outcome-a-single-center-experience
#1
Sanjay Kumar Yadav, Sanjiv Saigal, Narendra Singh Choudhary, Sujeet Saha, Jayant Kumar Sah, Neeraj Saraf, Naveen Kumar, Sanjay Goja, Amit Rastogi, Prashant Bhangui, A S Soin
BACKGROUND: Cytomegalovirus (CMV) is the most common viral infection in liver transplant recipients that influences the outcomes of liver transplantation. However, its impact on early outcomes following living donor liver transplantation (LDLT) is not fully defined in the Indian subcontinent. This study was done to assess the impact of CMV infection on early post-transplant outcomes in LDLT recipients. METHODS: Out of 272 LDLTs performed from January 2012 to April 2013, 151 recipients underwent CMV viral load analysis in plasma within 90 days post LDLT based on clinical suspicion...
April 18, 2018: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29667754/estrogen-regulated-expression-of-p450arom-genes-in-the-brain-and-ovaries-of-adult-female-indian-climbing-perch-anabas-testudineus
#2
Puja Pal, Sujata Roy Moulik, Shreyasi Gupta, Payel Guha, Suravi Majumder, Sourav Kundu, Buddhadev Mallick, Kousik Pramanick, Dilip Mukherjee
Cytochrome P450arom (CYP19), a product of cyp19a1 gene, catalyzes the conversion of androgens to estrogens and is essential for regulation of reproductive function in vertebrates. In the present study, we isolated partial cDNA encoding the ovarian (cyp19a1a) and brain (cyp19a1b) P450arom genes from adult female perch, Anabas testudineus and investigated their regulation by estrogen in vivo. Results demonstrated that cyp19a1a and cyp19a1b predominate in ovary and brain respectively, with quantity of both attuned to reproductive cycle...
April 18, 2018: Journal of Experimental Zoology. Part A, Ecological and Integrative Physiology
https://www.readbyqxmd.com/read/29667507/effect-of-inspiratory-muscle-training-imt-on-aerobic-capacity-respiratory-muscle-strength-and-rate-of-perceived-exertion-in-paraplegics
#3
Sonali Soumyashree, Jaskirat Kaur
OBJECTIVES: The purpose is to study the effect of inspiratory muscle training on aerobic capacity, respiratory muscle strength and rate of perceived exertion in paraplegics. STUDY DESIGN: Randomized controlled trial. SETTINGS: Rehabilitation department in Indian Spinal Injuries Centre, New Delhi. PARTICIPANTS: A sample of 30 paraplegics (T1-T12) were randomly allocated into two groups: inspiratory muscle training (IMT) group and control group...
April 18, 2018: Journal of Spinal Cord Medicine
https://www.readbyqxmd.com/read/29666946/pharmaceutical-products-as-emerging-contaminant-in-water-relevance-for-developing-nations-and-identification-of-critical-compounds-for-indian-environment
#4
Prakash Chinnaiyan, Santosh G Thampi, Mathava Kumar, K M Mini
Pharmaceuticals and personal care products (PPCPs) are contaminants of emerging concern and have been detected worldwide in water bodies in trace concentrations. Most of these emerging contaminants are not regulated in water quality standards except a few in the developed countries. In the case of developing countries, research in this direction is at a nascent stage. For the effective management of Pharmaceutical contaminants (PC) in developing countries, the relevance of PCs as an emerging contaminant has to be analyzed followed by regular monitoring of the environment...
April 17, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29666527/intransience-of-functional-components-and-distinctive-properties-of-amla-indian-gooseberry-ice-cream-during-short-term-storage
#5
Rajpreet Kaur Goraya, Usha Bajwa
Inclusion of processed amla have been found to enhance the functional properties and nutritional value of ice cream by augmenting the fiber content, total phenols, tannins, ascorbic acid and antioxidant activity. The present investigation assessed the changes in these constituents, color values (L, a* and b*), melting rate, sensory scores and microbiological quality of ice cream containing amla shreds, pulp, preserve, candy and powder during 60 days' storage at - 18 to - 20 °C. The total solids increased slightly whereas the antioxidant activity, total phenols, ascorbic acid and tannins decreased on storage...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666512/exploration-of-the-diversity-and-associated-health-benefits-of-traditional-pickles-from-the-himalayan-and-adjacent-hilly-regions-of-indian-subcontinent
#6
Rakhi Chakraborty, Swarnendu Roy
The Himalayas have provided shelter to the various communities for thousands of years and have remained the cradle for the origin of diverse cultures and traditions. The Himalayan belt is rich in biodiversity and have ushered mankind with numerous gifts for survival and existence. The art of pickling is believed to have developed independently among the different communities of this region. In this region, the main meal is supplemented with pickles or achar that not only adds flavour, but also enhances the value of the meal and often comes with inherent health benefits...
May 2018: Journal of Food Science and Technology
https://www.readbyqxmd.com/read/29666349/genetic-disease-in-india-and-the-west-compared-provisional-analysis-of-population-dynamics
#7
Nicholas Mitchison, Timothy Mitchison
The Indian Genetic Disease Database (IGDD) and Online Mendelian Inheritance in Man (OMIM) survey human populations that have different climate histories. Comparison of the two shows an outstanding difference in the relative frequency of recessive disease genes. Several of the diseases mediated at least in part by recessive gene mutations in India are not so mediated in the Western populations covered by OMIM, or are so mediated to a lesser extent. This we attribute to climate history, where population fall leading to inbreeding in the last ice age appears to have reduced the frequency of recessive disease genes in the Western world...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666346/genetic-heterogeneity-in-van-der-woude-syndrome-identification-of-nol4-and-irf6-haplotype-from-the-noncoding-region-as-candidates-in-two-families
#8
Priyanka Kumari Kumari, Akhtar Ali, Subodh Kumar Singh, Amit Chaurasia, Rajiva Raman
Van der Woude syndrome (VWS) shows an autosomal dominant pattern of inheritance with two known candidate genes, IRF6 and GRHL3. In this study, by employing genome-wide linkage analyses on two VWS affected families, we report the cosegregation of an intronic rare variant in NOL4 in one family, and a haplotype consisting of three variants in the noncoding region of IRF6 (introns 1, 8 and 3'UTR) in the other family. Using mouse, as well as human embryos as a model, we demonstrate the expression of NOL4 in the lip and palate primordia during their development...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666337/mitochondrial-signatures-revealed-panmixia-in-lutjanus-argentimaculatus-forssk%C3%A3-l-1775
#9
A Gopalakrishnan, N Vineesh, Shihab Ismail, Muktha Menon, K V Akhilesh, N S Jeena, M P Paulton, P Vijayagopal
Mangrove red snapper, Lutjanus argentimaculatus is a commercially important fish. The genetic stock structure of L. argentimaculatus from Indian waters was identified using mitochondrial ATPase 6 and ATPase 8, and cytochrome b (Cytb) genes. A 842 bp region of ATPase 6/8 genes and 1105 bp region of Cytb gene were amplified in 120 samples from six different locations along the Indian coast and obtained 58 and 66 haplotypes, respectively. The high haplotype and low nucleotide diversity values along with mismatch distribution, Tajima's D and Fu's Fs analysis suggested a genetic bottleneck events or founder effect, with subsequent population expansion in L...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29666325/identification-of-virulence-factors-and-type-iii-effectors-of-phylotype-i-indian-ralstonia-solanacearum-strains-rs-09-161-and-rs-10-244
#10
Trupti Asolkar, Raman Ramesh
Ralstonia solanacearum is a well-known phytopathogen causing bacterial wilt in a large number of agriculturally important crops. The pathogenicity of R. solanacearum is expressed due to the presence of various virulence factors and effector proteins. In this study, various virulence factors and type III effector proteins of R. solanacearum that are present in the strains Rs-09-161 and Rs-10-244 were identified through bioinformatics approach and compared with other reference strains. R. solanacearum strains, Rs-09-161 and Rs-10-244 belong to the phylotype I, biovar3, and are the only sequenced strains from India infecting solanaceous vegetables...
March 2018: Journal of Genetics
https://www.readbyqxmd.com/read/29665754/the-clinical-manifestations-and-response-to-treatment-in-south-africans-with-lupus-nephritis
#11
P G Mody, G M Mody, A Assounga
There are varying observations on the influence of ethnicity on the clinical spectrum and response to treatment in lupus nephritis (LN). We studied a multiethnic South African LN cohort to determine the clinical manifestations, histological involvement and response to therapy. We reviewed the records of LN patients at Inkosi Albert Luthuli Central Hospital in Durban. There were 105 patients, 92.5% females and they comprised 49.1% Indians and 45.3% African Blacks. The mean age was 31.3 ± 12.5 years, and 41...
January 1, 2018: Lupus
https://www.readbyqxmd.com/read/29665501/generation-of-an-integration-free-ipsc-line-cscri005-a-from-erythroid-progenitor-cells-of-a-healthy-indian-male-individual
#12
Kannan V Manian, Sumitha P Bharathan, Madhavi Maddali, Vivi M Srivastava, Alok Srivastava, Shaji Ramachandran Velayudhan
Reprogramming of somatic cells with higher genome integrity, and use of non-integrating gene delivery methods and xeno-free cell culture conditions aid in the generation of iPSCs which are more suitable for disease modelling and clinical applications. We describe here an iPSC line generated using such conditions, which expressed all the pluripotency markers, retained normal karyotype and exhibited the potential for tri-lineage differentiation, both in-vitro and in-vivo. This is the first iPSC line available from a healthy Indian individual for researchers...
April 3, 2018: Stem Cell Research
https://www.readbyqxmd.com/read/29665031/mortality-following-surgery-for-trauma-in-an-indian-trauma-cohort
#13
M Mansourati, V Kumar, M Khajanchi, M L Saha, S Dharap, R Seger, M Gerdin Wärnberg
BACKGROUND: India accounts for 20 per cent of worldwide trauma mortality. Little is known about the quality of trauma surgery in an Indian setting. The aim of this study was to estimate the overall perioperative mortality rate, and to assess the association between type of acute surgical intervention and perioperative mortality among adult patients treated for trauma in an urban Indian setting. METHODS: Data were obtained from injured adult patients enrolled in four urban Indian hospitals during 2013-2015...
April 17, 2018: British Journal of Surgery
https://www.readbyqxmd.com/read/29664944/ccl2-single-nucleotide-polymorphism-of-rs1024611-implicates-prominence-of-inflammatory-cascade-by-univariate-modeling-in-indian-amd
#14
Neel Kamal Sharma, Kaushal Sharma, Ramandeep Singh, Suresh Kumar Sharma, Akshay Anand
BACKGROUND: The role of chemotactic protein CCL2/MCP-1 has been widely explored in age related macular degeneration (AMD) patients as well as animal models through our previous studies. AIM: Aim of the study was to examine the association of another variance of CCL2, rs1024611 in pathophysiology of AMD. METHODS: This particular SNP has been found to be involved in inflammatory processes in various diseases. Total 171 subjects were recruited in the study with all demographic details by administering a standard questionnaire...
2018: PloS One
https://www.readbyqxmd.com/read/29664698/alcohol-consumption-and-chronic-liver-disease-mortality-in-new-mexico-and-the-united-states-1999-2013
#15
Laura E Tomedi, Jim Roeber, Michael Landen
OBJECTIVE: Current chronic liver disease (CLD) mortality surveillance methods may not adequately capture data on all causes of CLD mortality. The objective of this study was to calculate and compare CLD death rates in New Mexico and the United States by using both an expanded definition of CLD and estimates of the fractional impact of alcohol on CLD deaths. METHODS: We defined CLD mortality as deaths due to alcoholic liver disease, cirrhosis, viral hepatitis, and other liver conditions...
January 1, 2018: Public Health Reports
https://www.readbyqxmd.com/read/29664190/child-marriage-in-the-united-states-how-common-is-the-practice-and-which-children-are-at-greatest-risk
#16
Alissa Koski, Jody Heymann
CONTEXT: Marriage before the age of 18, commonly referred to as child marriage, is legal under varying conditions across the United States. The prevalence of child marriage among recent cohorts is unknown. METHODS: American Community Survey data for 2010-2014 were used to estimate the average national and state-level proportions of children who had ever been married. Prevalence was calculated by gender, race and ethnicity, and birthplace, and the living arrangements of currently married children were examined...
April 17, 2018: Perspectives on Sexual and Reproductive Health
https://www.readbyqxmd.com/read/29664031/association-of-330-interleukin-2-gene-polymorphism-with-oral-cancer
#17
Prithvi Kumar Singh, Vijay Kumar, Mohammad Kaleem Ahmad, Rajni Gupta, Abbas Ali Mahdi, Amita Jain, Jaishri Bogra, Girish Chandra
Background & objectives: Cytokines play an important role in the development of cancer. Several single-nucleotide polymorphisms (SNPs) of cytokine genes have been reported to be associated with the development and severity of inflammatory diseases and cancer predisposition. This study was undertaken to evaluate a possible association of interleukin 2 (IL-2) (- 330A>C) gene polymorphisms with the susceptibility to oral cancer. Methods: The SNP in IL-2 (-330A>C) gene was genotyped in 300 oral cancer patients and in similar number of healthy volunteers by polymerase chain reaction (PCR)-restriction fragment length polymorphism and the association of the gene with the disease was evaluated...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29664026/prenatal-screening-for-genetic-disorders-suggested-guidelines-for-the-indian-scenario
#18
REVIEW
Shubha R Phadke, Ratna D Puri, Prajnya Ranganath
Prenatal testing is the best strategy for reducing the burden of genetic disorders and congenital disabilities that cause significant postnatal functional impairment. Universal prenatal screening is advisable for common genetic disorders and congenital anomalies such as Down syndrome, beta-thalassaemia and neural tube defects. Several prenatal-screening tests are now available for Down syndrome, but knowledge about the appropriate timing of the test and the need for pre- and post-test counselling may not be updated among the primary care physicians...
December 2017: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/29663909/diagnosing-developmental-defects-of-enamel-pilot-study-of-online-training-and-accuracy
#19
Darya Dabiri, George J Eckert, Yihong Li, Kim Seow, Robert J Schroth, John Warren, J Timothy Wright, Shi Zhao, Margherita Fontana
PURPOSE: The purpose of this study was to assess dentists' ability to correctly identify and classify development defects of enamel (DDE). METHODS: The modified DDE (MDDE) index was used to classify enamel defects into two types: (1) enamel hypoplasia-pitted, grooved, or missing enamel; or (2) enamel opacity-translucency of enamel not caused by dental caries or fluorosis (can be either demarcated or diffuse). A panel of six experts selected and scored 36 images using the MDDE, and the consensus score was used as the gold standard score in the evaluation of survey respondents...
March 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29663718/epidemiology-and-genetic-characterization-of-peste-des-petits-ruminants-virus-in-bangladesh
#20
Mohammed Z Rahman, Najmul Haider, Emily S Gurley, Sadia Ahmed, Mozaffar G Osmani, Muhammad B Hossain, Ariful Islam, Shahneaz A Khan, Mohammad Enayet Hossain, Jonathan H Epstein, Nord Zeidner, Mustafizur Rahman
Peste des petits ruminants (PPR) is an acute, highly contagious disease responsible for high morbidity and mortality rates in susceptible sheep and goats. Adequate knowledge of the diversity of circulating strains of PPR virus will help livestock authorities choose appropriate vaccines. The objective of this study was to describe the epidemiology of PPR and characterize the strains circulating in Bangladesh. Veterinarians enrolled goats showing signs consistent with PPR, including diarrhoea, fever and respiratory distress, from three veterinary hospitals...
March 8, 2018: Veterinary Medicine and Science
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