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https://www.readbyqxmd.com/read/27879041/cyanine-anchored-silica-nanochannels-for-light-driven-synergistic-thermo-chemotherapy
#1
Yibin Deng, Li Huang, Hong Yang, Hengte Ke, Hui He, Zhengqing Guo, Tao Yang, Aijun Zhu, Hong Wu, Huabing Chen
Smart nanoparticles are increasingly important in a variety of applications such as cancer therapy. However, it is still a major challenge to develop light-responsive nanoparticles that can maximize the potency of synergistic thermo-chemotherapy under light irradiation. Here, spatially confined cyanine-anchored silica nanochannels loaded with chemotherapeutic doxorubicin (CS-DOX-NCs) for light-driven synergistic cancer therapy are introduced. CS-DOX-NCs possess a J-type aggregation conformation of cyanine dye within the nanochannels and encapsulate doxorubicin through the π-π interaction with cyanine dye...
November 23, 2016: Small
https://www.readbyqxmd.com/read/27575391/temperature-controlled-radiofrequency-ablation-of-different-tissues-using-two-compartment-models
#2
Sundeep Singh, Ramjee Repaka
PURPOSE: This study aims to analyse the efficacy of temperature-controlled radiofrequency ablation (RFA) in different tissues. MATERIALS AND METHODS: A three-dimensional, 12 cm cubical model representing the healthy tissue has been studied in which spherical tumour of 2.5 cm has been embedded. Different body sites considered in the study are liver, kidney, lung and breast. The thermo-electric analysis has been performed to estimate the temperature distribution and ablation volume...
August 30, 2016: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/27399482/203%C3%A2-insular-depth-electrode-in-pediatric-treatment-refractory-epilepsy
#3
Luke Tomycz, Ali Haider, Maura Hamilton, David B Clarke, Mark R Lee
INTRODUCTION: It has been increasingly recognized that the insular cortex plays an important role in frontotemporal epilepsy (FTE) in children. The insula, however, cannot properly by monitored with conventional subdural grids, and open surgical resection of the insula is technically difficult and often associated with significant morbidity. Stereotactically placed insular depth electrodes allow direct and comprehensive monitoring of this region, and can easily be replaced with a laser applicator for minimally invasive treatment via thermo-ablation...
August 2016: Neurosurgery
https://www.readbyqxmd.com/read/27394136/thermo-sensitive-hydrogel-for-preventing-bowel-injury-in-percutaneous-renal-radiofrequency-ablation
#4
Xin Wang, Xiaozhi Zhao, Tingsheng Lin, Hongqian Guo
PURPOSE: Percutaneous radiofrequency ablation (PRFA) has been used to ablate renal neoplasms with good outcome. However, if bowel lies adjacent to a tumor, ablation increases the risk of thermal bowel injury, and the consequences could be fatal. We describe the technique, effectiveness and safety of using thermo-sensitive hydrogel as insulation to displace the bowel away during PRFA. MATERIALS AND METHODS: The study was divided into two main parts: the in vitro and in vivo studies...
October 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27161069/rare-complications-after-lung-percutaneous-radiofrequency-ablation-incidence-risk-factors-prevention-and-management
#5
REVIEW
Nicolas Alberti, Xavier Buy, Nora Frulio, Michel Montaudon, Mathieu Canella, Afshin Gangi, Amandine Crombe, Jean Palussière
Among image-guided thermo-ablative techniques, percutaneous radiofrequency ablation (PRFA) is the most widely used technique for the treatment of primary and secondary lung malignancies. Tolerance of PRFA in the lung is excellent. However, relatively little is known about potential rare complications. This article presents both the clinical and imaging features of lung PRFA complications as well as their prevention and management. Complications may be classified in four groups: pleuropulmonary (e.g., bronchopleural or bronchial fistula, delayed abscess or aspergilloma inside post-PRFA cavitations, pulmonary artery pseudo aneurysm, gas embolism and interstitial pneumonia); thoracic wall and vertebral (e...
June 2016: European Journal of Radiology
https://www.readbyqxmd.com/read/26792607/-effect-of-thermo-sensitive-matrigel-on-minimization-of-thermal-injury-to-the-nearby-structures-in-radiofrequency-ablation-of-subcapsular-hepatic-tumors-in-a-rat-model
#6
J J Fu, S Wang, R H Guan, W Yang, K Yan, M H Chen
OBJECTIVE: To evaluate the effect and safety of using thermo-sensitive Matrigel as artificial ascites on minimizing thermal injury to the nearby structures in a rat model of radiofrequency (RF) ablation of the liver. METHODS: In this research, the morphological characterization of Matrigel was observed at different temperatures in vitro. In vivo study was conducted by using 42 SD rats in Matrigel, Saline and control groups of 14 rats each. Artificial ascites with 10 ml of Matrigel or saline was produced under ultrasound guidance before RF in the experimental groups...
January 5, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/26785043/does-thermosensitive-liposomal-vinorelbine-improve-end-point-survival-after-percutaneous-radiofrequency-ablation-of-liver-tumors-in-a-mouse-model
#7
Song Wang, Xing-Guo Mei, S Nahum Goldberg, Muneeb Ahmed, Jung-Chieh Lee, Wei Gong, Hai-Bo Han, Kun Yan, Wei Yang
Purpose To investigate the role of thermosensitive liposome-encapsulated vinorelbine (Thermo-Vin) in combined radiofrequency (RF) ablation of liver tumors. Materials and Methods Approval from the institutional animal care and use committee was obtained before this study. First, the anticancer efficacy of Thermo-Vin was assessed in vitro (H22 cells) for 72 hours at 37°C or 42°C. Next, 203 H22 liver adenocarcinomas were implanted in 191 mice for in vivo study. Tumors were randomized into seven groups: (a) no treatment, (b) treatment with RF ablation alone, (c) treatment with RF ablation followed by free vinorelbine (Free-Vin) at 30 minutes, (d) treatment with RF ablation followed by empty liposomes (Empty-Lip+RF), (e) treatment with RF ablation followed by Thermo-Vin (5 mg/kg), (f) treatment with RF ablation followed by Thermo-Vin (10 mg/kg), and (g) treatment with RF ablation followed by Thermo-Vin (20 mg/kg)...
June 2016: Radiology
https://www.readbyqxmd.com/read/26654626/acid-responsive-therapeutic-polymer-for-prolonging-nanoparticle-circulation-lifetime-and-destroying-drug-resistant-tumors
#8
Ji-Gang Piao, Feng Gao, Lihua Yang
How to destroy drug-resistant tumor cells remains an ongoing challenge for cancer treatment. We herein report on a therapeutic nanoparticle, aHLP-PDA, which has an acid-activated hemolytic polymer (aHLP) grafted onto photothermal polydopamine (PDA) nanosphere via boronate ester bond, in efforts to ablate drug-resistant tumors. Upon exposure to oxidative stress and/or near-infrared laser irradiation, aHLP-PDA nanoparticle responsively releases aHLP, likely via responsive cleavage of boronate ester bond, and thus responsively exhibits acid-facilitated mammalian-membrane-disruptive activity...
January 13, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26608619/nanocomposite-hydrogel-incorporating-gold-nanorods-and-paclitaxel-loaded-chitosan-micelles-for-combination-photothermal-chemotherapy
#9
Nan Zhang, Xuefan Xu, Xue Zhang, Ding Qu, Lingjing Xue, Ran Mo, Can Zhang
Development of combination photothermal-chemotherapy platform is of great interest for enhancing antitumor efficacy and inhibiting tumor recurrence, which supports selective and dose-controlled delivery of heat and anticancer drugs to tumor. Here, an injectable nanocomposite hydrogel incorporating PEGylated gold nanorods (GNRs) and paclitaxel-loaded chitosan polymeric micelles (PTX-M) is developed in pursuit of improved local tumor control. After intratumoral injection, both GNRs and PTX-M can be simultaneously delivered and immobilized in the tumor tissue by the thermo-sensitive hydrogel matrix...
January 30, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26353572/validity-of-the-taylor-sedov-theory-for-studying-laser-induced-phase-explosion-and-shock-waves
#10
Mohammad Hendijanifard, David A Willis
Phase explosion is a phase change process that occurs during short pulse laser ablation. Phase explosion is a result of homogeneous nucleation of vapor in the superheated melt and results in a rapid transition from a superheated melt to a mixture of vapor and liquid droplets that expand from the surface. The sudden phase transition results in rapid material removal, and if occurring in an ambient gas, causes a shock wave to propagate away from the surface. Measurements of this shock wave are commonly used with the Taylor-Sedov blast wave theory to estimate shock wave pressure and temperature...
April 2015: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/26333115/multifunctional-theranostic-nanoplatform-for-cancer-combined-therapy-based-on-gold-nanorods
#11
Wei-Hai Chen, Cai-Xia Yang, Wen-Xiu Qiu, Guo-Feng Luo, Hui-Zhen Jia, Qi Lei, Xiao-Yong Wang, Gang Liu, Ren-Xi Zhuo, Xian-Zheng Zhang
Nanomaterials that integrate diagnostic and therapeutic functions within a single nanoplatform promise great advances in revolutionizing cancer therapy. A smart multifunctional theranostic drug-delivery system (DDS) based on gold nanorods (abbreviated as GNR/TSDOX) is designed for cancer-targeted imaging and imaging-guided therapy. In this intelligent theranostic DDS, the active targeting ligand biotin is introduced to track cancer sites in vivo. With the aid of photothermal/photoacoustic imaging, GNR/TSDOX can ablate cancer specifically and effectively...
October 28, 2015: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/26290324/radiofrequency-thermo-ablation-of-pvns-in-the-knee-initial-results
#12
Radhesh K Lalam, Gillian L Cribb, Victor N Cassar-Pullicino, Wim P Cool, Jaspreet Singh, Prudencia N M Tyrrell, Bernhard J Tins, Naomi Winn
INTRODUCTION: Pigmented villonodular synovitis (PVNS) is normally treated by arthroscopic or open surgical excision. We present our initial experience with radiofrequency thermo-ablation (RF ablation) of PVNS located in an inaccessible location in the knee. MATERIALS: Review of all patients with histologically proven PVNS treated with RF ablation and with at least 2-year follow-up. RESULTS: Three patients met inclusion criteria and were treated with RF ablation...
December 2015: Skeletal Radiology
https://www.readbyqxmd.com/read/26234690/a-novel-single-walled-carbon-nanotube-swcnt-functionalization-agent-facilitating-in-vivo-combined-chemo-thermo-therapy
#13
Liwen Zhang, Pengfei Rong, Minglong Chen, Shi Gao, Lei Zhu
Carbon nanotubes (CNTs) have shown intriguing applications in biotechnological and biomedical fields due to their unique shape and properties. However, the fact that unmodified CNTs are prone to aggregation, stunts CNTs applications under physiological conditions. In this research, we found that as little as 1/5th the single walled carbon nanotube (SWCNT) weight of Evans Blue (EB) is capable of dispersing SWCNT as well as facilitating SWCNT functionalization. In view of the binding between EB and albumin, the yielding product (SWCNT/EB) demonstrated extreme stability for weeks under physiological conditions and it can be endowed with a therapeutic ability by simply mixing SWCNT/EB with an albumin based drug...
October 21, 2015: Nanoscale
https://www.readbyqxmd.com/read/26181349/dually-ph-reduction-responsive-vesicles-for-ultrahigh-contrast-fluorescence-imaging-and-thermo-chemotherapy-synergized-tumor-ablation
#14
Aijun Zhu, Ke Miao, Yibin Deng, Hengte Ke, Hui He, Tao Yang, Miao Guo, Yanli Li, Zhengqing Guo, Yangyun Wang, Xiangliang Yang, Youliang Zhao, Huabing Chen
Smart nanocarriers are of particular interest as nanoscale vehicles of imaging and therapeutic agents in the field of theranostics. Herein, we report dually pH/reduction-responsive terpolymeric vesicles with monodispersive size distribution, which are constructed by assembling acetal- and disulfide-functionalized star terpolymer with near-infrared cyanine dye and anticancer drug. The vesicular nanostructure exhibits multiple theranostic features including on-demand drug releases responding to pH/reduction stimuli, enhanced photothermal conversion efficiency of cyanine dye, and efficient drug translocation from lysosomes to cytoplasma, as well as preferable cellular uptakes and biodistribution...
August 25, 2015: ACS Nano
https://www.readbyqxmd.com/read/26073117/fractional-treatment-of-aging-skin-with-tixel-a-clinical-and-histological-evaluation
#15
Monica Elman, Nathalie Fournier, Gilbert Barnéon, Eric F Bernstein, Gary Lask
OBJECTIVE: This study presents clinical results of Tixel, a new fractional skin resurfacing system based on thermo-mechanical ablation technology. Tixel employs a hot (400°C) metallic tip consisting of 81 pyramids. Treatment is performed by rapidly advancing the tip to the skin for a preset tip-skin contact duration. Thermal energy transfer to the skin creates micro-craters by evaporation. METHODS: Treatment results with tip types, D and S, with high and low thermal conductivity, were evaluated...
2016: Journal of Cosmetic and Laser Therapy: Official Publication of the European Society for Laser Dermatology
https://www.readbyqxmd.com/read/26017774/minimally-invasive-surgical-approaches-for-temporal-lobe-epilepsy
#16
REVIEW
Edward F Chang, Dario J Englot, Sumeet Vadera
Surgery can be a highly effective treatment for medically refractory temporal lobe epilepsy (TLE). The emergence of minimally invasive resective and nonresective treatment options has led to interest in epilepsy surgery among patients and providers. Nevertheless, not all procedures are appropriate for all patients, and it is critical to consider seizure outcomes with each of these approaches, as seizure freedom is the greatest predictor of patient quality of life. Standard anterior temporal lobectomy (ATL) remains the gold standard in the treatment of TLE, with seizure freedom resulting in 60-80% of patients...
June 2015: Epilepsy & Behavior: E&B
https://www.readbyqxmd.com/read/25960147/heat-transfer-within-hydrodissection-fluids-an-analysis-of-thermal-conduction-and-convection-using-liquid-and-gel-materials
#17
Alexander Johnson, Christopher Brace
Interventional oncology procedures such as thermal ablation are becoming widely used for many tumours in the liver, kidney and lung. Thermal ablation refers to the focal destruction of tissue by generating cytotoxic temperatures in the treatment zone. Hydrodissection - separating tissues with fluids - protects healthy tissues adjacent to the ablation treatment zone to improve procedural safety, and facilitate more aggressive power application or applicator placement. However, fluids such as normal saline and 5% dextrose in water (D5W) can migrate into the peritoneum, reducing their protective efficacy...
2015: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/25867873/treatment-of-compensatory-hyperhidrosis-of-the-trunk-with-radiofrequency-ablation
#18
Süleyman Deniz, Kuthan Kavaklı, Hasan Çaylak, Tarık Purtuloğlu, Ersin Sapmaz, Gökhan İnangil, Abdulkadir Atım, Sedat Gürkök, Ercan Kurt
OBJECTIVES: Although Endoscopic Thoracic Sympathectomy is a widely accepted treatment method for patients with palmar hyperhidrosis, compensatory hyperhidrosis of the trunk remains a challenging side effect of the procedure. No satisfactory treatment options for this side effect were available until now. In this study, we aimed to define a new procedure for the treatment of compensatory hyperhidrosis of the trunk. METHODS: A total of 10 patients admitted our institution for the treatment of compensatory hyperhidrosis of the trunk were enrolled in the study between November 2010 and January 2012 in a prospective manner...
2015: Aǧrı: Ağrı (Algoloji) Derneği'nin Yayın Organıdır, the Journal of the Turkish Society of Algology
https://www.readbyqxmd.com/read/25797920/multi-stimuli-responsive-cu2s-nanocrystals-as-trimodal-imaging-and-synergistic-chemo-photothermal-therapy-agents
#19
Aby Cheruvathoor Poulose, Srivani Veeranarayanan, M Sheikh Mohamed, Yutaka Nagaoka, Rebeca Romero Aburto, Trevor Mitcham, Pulickel M Ajayan, Richard R Bouchard, Yasushi Sakamoto, Yasuhiko Yoshida, Toru Maekawa, D Sakthi Kumar
A size and shape tuned, multifunctional metal chalcogenide, Cu2S-based nanotheranostic agent is developed for trimodal imaging and multimodal therapeutics against brain cancer cells. This theranostic agent was highly efficient in optical, photoacoustic and X-ray contrast imaging systems. The folate targeted NIR-responsive photothermal ablation in synergism with the chemotherapeutic action of doxorubicin proved to be a rapid precision guided cancer-killing module. The multi-stimuli, i.e., pH-, thermo- and photo-responsive drug release behavior of the nanoconjugates opens up a wider corridor for on-demand triggered drug administration...
May 14, 2015: Nanoscale
https://www.readbyqxmd.com/read/25613756/gelatin-microcapsules-for-enhanced-microwave-tumor-hyperthermia
#20
Qijun Du, Changhui Fu, Jian Tie, Tianlong Liu, Linlin Li, Xiangling Ren, Zhongbing Huang, Huiyu Liu, Fangqiong Tang, Li Li, Xianwei Meng
Local and rapid heating by microwave (MW) irradiation is important in the clinical treatment of tumors using hyperthermia. We report here a new thermo-seed technique for the highly efficient MW irradiation ablation of tumors in vivo based on gelatin microcapsules. We achieved 100% tumor elimination in a mouse model at an ultralow power of 1.8 W without any side-effects. The results of MTT assays, a hemolysis test and the histological staining of organs indicated that the gelatin microcapsules showed excellent compatibility with the physiological environment...
February 21, 2015: Nanoscale
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