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https://www.readbyqxmd.com/read/28655121/high-grade-poorly-differentiated-neuroendocrine-carcinoma-of-the-breast-with-low-oncotype-dx-recurrence-score-a%C3%A2-case%C3%A2-report
#1
Carlos A Munoz-Zuluaga, Sandy Kotiah, Kimberley D Studeman
Primary neuroendocrine carcinoma of the breast (NECB) is a rare malignant tumor with controversial biological behavior and a lack of data guiding treatment decisions due to its scarcity. Cancer gene-expression profiling tests provide a better indication of clinical prognosis and help determine the best clinical management versus the traditional clinical and pathological parameters. This is a report of a NECB with a genetic assay that showed a low-risk tumor despite high-grade and poorly differentiated histopathological features...
June 23, 2017: Breast Disease
https://www.readbyqxmd.com/read/28655081/-prognostic-analysis-of-colorectal-liver-metastases-treated-by-surgery-combined-with-intraoperative-radiofrequency-ablation
#2
R Mao, J J Zhao, X Y Bi, H Zhao, Z Y Li, Z Huang, Y F Zhang, X Chen, H J Hu, X L Wu, X H Hu, J Q Cai
Objective: To investigate the clinical value of intraoperative radiofrequency ablation (RFA) in the treatment of colorectal liver metastasis (CLM). Methods: A retrospectively analysis of 187 patients with CLM who underwent liver resection with or without RFA from January 2009 to August 2016 in Department of Hepatobiliary Surgery, Cancer Hospital, Chinese Academy of Medical Sciences was performed. According to whether RFA was used intraoperatively, patients were divided into resection only group and combined treatment group...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28655080/-a-retrospective-controlled-clinical-study-of-single-incision-plus-one-port-laparoscopic-surgery-for-sigmoid-colon-and-upper-rectal-cancer
#3
G X Li, J M Li, Y N Wang, H J Deng, T Y Mou, H Liu
Objective: To evaluate the short-term and oncologic outcomes of single-incision plus one port laparoscopic surgery (SILS+ 1) for sigmoid colon and upper rectal cancer. Methods: The clinic data of 46 patients with sigmoid colon and upper rectal cancer underwent SILS+ 1 at Department of General Surgery, Nanfang Hospital, Southern Medical University from September 2013 to September 2014 were retrospectively reviewed (SILS+ 1 group). After generating 1∶1 ration propensity scores given the covariates of age, gender, body mass index, American Society of Anesthesiologists score, surgeons, tumor location, the distance of tumor from anal, tumor diameter, and pathologic TNM stage, 46 patients with sigmoid colon and upper rectal cancer underwent conventional laparoscopic surgery (CLS) in the same time were matched as CLS group...
July 1, 2017: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/28654655/the-prognostic-value-of-bap1-pbrm1-ps6-pten-tgase2-pd-l1-ca9-psma-and-ki-67-tissue-markers-in-localized-renal-cell-carcinoma-a-retrospective-study-of-tissue-microarrays-using-immunohistochemistry
#4
Sung Han Kim, Weon Seo Park, Eun Young Park, Boram Park, Jungnam Joo, Jae Young Joung, Ho Kyung Seo, Kang Hyun Lee, Jinsoo Chung
OBJECTIVE: To assess the prognostic roles of BAP1, PBRM1, pS6, PTEN, TGase2, PD-L1, CA9, PSMA, and Ki-67 tissue biomarkers in localized renal cell carcinoma (RCC). METHODS: Patients who underwent a nephrectomy during 1992-2015 and had a primary specimen of their kidney tumor were included. The nine tissue biomarkers were immunohistochemically stained on tissue microarrays of RCC, and the semi-quantitative H-score, including intensity score, was used to grade the sample...
2017: PloS One
https://www.readbyqxmd.com/read/28654567/worry-in-head-and-neck-cancer-caregivers-the-role-of-survivor-factors-care-related-stressors-and-loneliness-in-predicting-fear-of-recurrence
#5
Rebecca Maguire, Paul Hanly, Myles Balfe, Aileen Timmons, Philip Hyland, Eleanor O'Sullivan, Phyllis Butow, Linda Sharp
BACKGROUND: Fear of recurrence (FOR) is a primary concern for both cancer survivors and their caregivers, yet little is known about what care-related factors exacerbate this worry. OBJECTIVES: This study aimed to establish the role of care-related stressors-as distinct from survivor characteristics-in predicting FOR in head and neck cancer caregivers. METHODS: HNC survivor-caregiver dyads took part in a mailed survey. Survivors provided information on health and quality of life (using the Functional Assessment of Cancer Therapy Questionnaire)...
July 2017: Nursing Research
https://www.readbyqxmd.com/read/28653142/prognostic-significance-of-preoperative-controlling-nutritional-status-conut-score-in-patients-undergoing-hepatic-resection-for-hepatocellular-carcinoma
#6
Norifumi Harimoto, Tomoharu Yoshizumi, Kazuhito Sakata, Akihisa Nagatsu, Takashi Motomura, Shinji Itoh, Noboru Harada, Toru Ikegami, Hideaki Uchiyama, Yuji Soejima, Yoshihiko Maehara
BACKGROUND: The Controlling Nutritional Status (CONUT) score is an objective tool widely used to assess nutritional status in patients with inflammatory disease, chronic heart failure, and chronic liver disease. The relationship between CONUT score and prognosis in patients who have undergone hepatic resection, however, has not been evaluated. METHODS: Data were retrospectively collected for 357 consecutive patients with hepatocellular carcinoma (HCC) who had undergone hepatic resection with curative intent between January 2004 and December 2015...
June 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28652773/long-term-outcomes-of-neoadjuvant-chemotherapy-followed-by-concurrent-chemoradiotherapy-ccrt-vs-ccrt-alone-for-nasopharyngeal-carcinoma-in-the-era-of-intensity-modulated-radiation-therapy-using-propensity-score-matching-method
#7
Xueling Chen, Xiaodong Zhu, Zhongguo Liang, Ling Li, Song Qu, Kaihua Chen, Xinbin Pan
PURPOSE: Whether neoadjuvant chemotherapy (NCT) followed by concurrent chemoradiotherapy (CCRT) could improve survival in nasopharyngeal carcinoma (NPC) remains controversial especially in the era of intensity-modulated radiation therapy (IMRT), and we explored the role of NCT for NPC patients. PATIENTS AND METHODS: A retrospective review was conducted of 255 NPC patients treated with NCT+CCRT (n=67) or CCRT alone (n=188) based on IMRT between December 2006 and December 2012...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28652159/skin-to-tumor-distance-predicts-treatment-failure-of-t1a-renal-cell-carcinoma-following-percutaneous-cryoablation
#8
Simone L Vernez, Zhamshid Okhunov, Kamaljot Kaler, Ramy F Youssef, Rahul Dutta, Arkadiy Palvanov, Paras Shah, Kathryn Osann, David N Siegel, Igor Lobko, Louis Kavoussi, Ralph V Clayman, Jaime Landman
OBJECTIVE: To determine the impact of skin-to-tumor (STT) distance on the risk for treatment failure following PCA. METHODS: We retrospectively reviewed patients who underwent PCA with documented T1a recurrent renal cell carcinoma (RCC) at two academic centers between 2005 and 2015. Patient demographics, tumor characteristics, perioperative and post-operative course variables were collected. Additionally, we measured the STT by averaging the distance from the skin to the center of the tumor at 0, 45 and 90 degrees on preoperative computed tomography imaging...
June 23, 2017: Urology
https://www.readbyqxmd.com/read/28652121/high-intensity-focused-ultrasound-for-radio-recurrent-prostate-cancer-a-north-american-clinical-trial
#9
Tonye A Jones, Joseph Chin, David Mcleod, Jack Barkin, Allan Pantuck, Leonard S Marks
PURPOSE: To determine the safety and efficacy of whole-gland HIFU in men with radio-recurrent prostate cancer (CaP). MATERIALS AND METHODS: 100 men with clinically localized recurrence of CaP at least 2 years after EBRT received whole-gland HIFU in an open-label trial (2009 to 2012). Treatments were performed at 16 sites in the U.S. (14) and Canada (2). Primary endpoint was a combination of both PSA nadir ≤0.5 ng/ml and negative biopsy at 12 months. Validated questionnaires were used to monitor changes in urinary and sexual function...
June 23, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28652054/coracoid-bone-block-transfer-procedure-correlation-between-subscapularis-volume-below-the-bone-graft-and-shoulder-stability
#10
A Toffoli, J Teissier, H Lenoir, C Lazerges, B Coulet, C Cyteval, M Chammas
INTRODUCTION: Coracoid bone graft transfer has become the gold standard in patients with recurrent anterior shoulder instability associated with bony defect. Several studies have shown that the main stabilizing component of this procedure is the sling effect by the conjoint tendon and the lower portion ofsubscapularis(SS). The purpose of this study was to determine whether a larger SS volume below the bone block was correlated to greater postoperative shoulder stability. MATERIALS AND METHODS: This prospective study included a cohort of patients who underwent open coracoid bone graft transfer for post-traumatic recurrent anterior shoulder instability...
June 23, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28652016/overall-effectiveness-of-rivaroxaban-in-patients-with-pulmonary-embolism
#11
Li Wang, Onur Baser, Phil Wells, W Frank Peacock, Craig I Coleman, Gregory J Fermann, Jeff Schein, Concetta Crivera
PURPOSE: Due to limited evidence on the impact of rivaroxaban in clinical practice, we compared the effectiveness of rivaroxaban versus standard of care (SOC) among patients in the Veterans Health Administration. METHODS: Adult patients with continuous enrollment in a health plan with medical and pharmacy benefits for ≥12 months before and ≥3 months after an inpatient diagnosis of pulmonary embolism (PE) between October 1, 2011, and June 30, 2015, and a prescription claim for an anticoagulant during the index hospitalization, were included...
June 23, 2017: Clinical Therapeutics
https://www.readbyqxmd.com/read/28651940/comparison-of-outcomes-between-muscle-sparing-thoracotomy-and-video-assisted-thoracic-surgery-in-patients-with-ct1-n0-m0-lung-cancer
#12
Yue Zhao, Guodong Li, Yang Zhang, Hong Hu, Jie Zhang, Yihua Sun, Haiquan Chen
OBJECTIVE: To compare short-term complications and long-term survival outcomes between muscle-sparing thoracotomy (MST) and video-assisted thoracic surgery (VATS) groups using a propensity-score matching process. METHODS: One thousand eighty-three patients with cT1 N0 M0 lung cancer from January 2009 to December 2014 who underwent lobectomy and a systematic lymph node dissection were retrospectively included, and statistical analyses including a propensity-score matching process were used to compare short-term and long-term outcomes...
May 20, 2017: Journal of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28651494/decreased-expression-of-tcf12-contributes-to-progression-and-predicts-biochemical-recurrence-in-patients-with-prostate-cancer
#13
Qing-Biao Chen, Ying-Ke Liang, Yan-Qiong Zhang, Min-Yao Jiang, Zhao-Dong Han, Yu-Xiang Liang, Yue-Ping Wan, Jie Yin, Hui-Chan He, Wei-de Zhong
As a member of helix-loop-helix protein family, transcription factor 12 functions as either an oncogene or a tumor suppressor in various human cancers. However, there are no reports on its involvement in prostate cancer. To investigate clinical relevance of transcription factor 12 in prostate cancer and to evaluate its roles in malignant phenotypes of this cancer in vitro and in vivo, we here examined expression patterns of transcription factor 12 protein in 50 prostate cancer tissue specimens by immunohistochemistry...
June 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28651115/ten-year-results-of-applying-an-original-scoring-system-for-addressing-adjuvant-therapy-use-after-breast-conserving-surgery-for-ductal-carcinoma-in-situ-of-the-breast
#14
Massimiliano Gennaro, Maria Carmen De Santis, Luigi Mariani, Salvatore Lo Vullo, Vera Cappelletti, Roberto Agresti, Umberto Cortinovis, Biagio Paolini, Serena Di Cosimo, Maria Luisa Carcangiu, Maria Grazia Daidone, Laura Lozza
PURPOSE: Although large-scale randomised clinical trials have established that radiotherapy (RT) - alone or combined with hormonal therapy (HT) - is effective in reducing the risk of ipsilateral breast tumour recurrence (IBTR), overall survival does not seem to be improved by adjuvant therapies. We sought to ascertain whether specific criteria can be adopted to avoid RT with an acceptable rate of IBTR after breast-conserving surgery (BCS) achieving tumour-free margins. PATIENTS AND METHODS: This non-randomised prospective study concerned the outcome of patients who underwent BCS for ductal carcinoma in situ (DCIS) and were prospectively assessed by means of an established scoring system based on width of free margins in association with age <40, presence of comedonecrosis, high grade, ER negativity and HER2 positivity, to orient the use of any adjuvant therapies...
June 23, 2017: Breast: Official Journal of the European Society of Mastology
https://www.readbyqxmd.com/read/28650745/longer-duration-antimicrobial-therapy-does-not-prevent-treatment-failure-in-high-risk-patients-with-complicated-intra-abdominal-infections
#15
Taryn E Hassinger, Christopher A Guidry, Ori D Rotstein, Therese M Duane, Heather L Evans, Charles H Cook, Patrick J O'neill, John E Mazuski, Reza Askari, Lena M Napolitano, Nicholas Namias, Preston R Miller, E Patchen Dellinger, Raul Coimbra, Christine S Cocanour, Kaysie L Banton, Joseph Cuschieri, Kimberley Popovsky, Robert G Sawyer
BACKGROUND: Recent studies have suggested the length of treatment of intra-abdominal infections (IAIs) can be shortened without detrimental effects on patient outcomes. However, data from high-risk patient populations are lacking. We hypothesized that patients at high risk for treatment failure will benefit from a longer course of antimicrobial therapy. METHODS: Patients enrolled in the Study to Optimize Peritoneal Infection Therapy (STOP-IT) trial were evaluated retrospectively to identify risk factors associated with treatment failure, which was defined as the composite outcome of recurrent IAI, surgical site infection, or death...
June 26, 2017: Surgical Infections
https://www.readbyqxmd.com/read/28650354/prediction-of-hepatocellular-carcinoma-recurrence-beyond-milan-criteria-after-resection-validation-of-a-clinical-risk-score-in-an-international-cohort
#16
Jian Zheng, Joanne F Chou, Mithat Gönen, Neeta Vachharajani, William C Chapman, Maria B Majella Doyle, Simon Turcotte, Franck Vandenbroucke-Menu, Réal Lapointe, Stefan Buettner, Bas Groot Koerkamp, Jan N M Ijzermans, Chung Yip Chan, Brian K P Goh, Jin Yao Teo, Juinn Huar Kam, Prema R Jeyaraj, Peng Chung Cheow, Alexander Y F Chung, Pierce K H Chow, London L P J Ooi, Vinod P Balachandran, T Peter Kingham, Peter J Allen, Michael I D'Angelica, Ronald P DeMatteo, William R Jarnagin, Ser Yee Lee
OBJECTIVE: This study aims to validate a previously reported recurrence clinical risk score (CRS). SUMMARY OF BACKGROUND DATA: Salvage transplantation after hepatocellular carcinoma (HCC) resection is limited to patients who recur within Milan criteria (MC). Predicting recurrence patterns may guide treatment recommendations. METHODS: An international, multicenter cohort of R0 resected HCC patients were categorized by MC status at presentation...
July 22, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28649774/osteoradionecrosis-of-the-jaws-definition-epidemiology-staging-and-clinical-and-radiological-findings-a-concise-review
#17
REVIEW
Aristeidis Chronopoulos, Theodora Zarra, Michael Ehrenfeld, Sven Otto
Osteoradionecrosis (ORN) of the jaws is a pernicious complication of radiation therapy for head and neck tumours. This article aims to provide an update on data related to the definition, epidemiology, staging, and clinical and radiological findings of ORN of the jaws. Using certain keywords, an electronic search was conducted spanning the period from January 1922 to April 2014 to identify the available related investigations. Pooled data were then analysed. ORN is described as exposed irradiated bone that fails to heal over a period of 3 months without evidence of persisting or recurrent tumour...
June 25, 2017: International Dental Journal
https://www.readbyqxmd.com/read/28648902/self-reported-unsteadiness-predicts-fear-of-falling-activity-restriction-falls-and-disability
#18
Orna A Donoghue, Annalisa Setti, Neil O'Leary, Rose Anne Kenny
OBJECTIVE: To determine if self-reported unsteadiness during walking is associated with fear of falling (FOF), fear-related activity restriction, falls, and disability over 2 years in community-dwelling adults. DESIGN: Data were obtained from the first 2 waves of The Irish Longitudinal Study on Ageing, a population-based study. SETTING: Participants completed a home-based interview and a center-based health assessment at baseline and a home-based interview at 2 years follow-up...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28647957/-long-term-effectiveness-of-transvaginal-high-uterosacral-ligament-suspension
#19
L Duan, Y X Lu, W J Shen, X Liu, J X Liu, Y H Zhang, J Ge, Y Zhao, K Niu, W Y Wang
Objective: To assess the long-term effectiveness of the transvaginal high uterosacral ligament suspension (HUS) in women suffering from advanced pelvic organ prolapse (POP). Methods: A retrospective review of records identified 118 women who underwent transvaginal HUS with or without additional concomitant anterior and (or) posterior repairs from June 2003 to August 2009 in the First Affiliated Hospital, General Hospital of People's Liberation Army. Of 118 women, 104 women completed the follow-up during study period; these 104 women were analysed...
June 25, 2017: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28647915/impact-of-the-21-gene-recurrence-score-on-outcome-in-patients-with-invasive-lobular-carcinoma-of-the-breast
#20
Scott Kizy, Jing Li Huang, Schelomo Marmor, Todd M Tuttle, Jane Yuet Ching Hui
PURPOSE: Invasive lobular carcinoma (ILC) of the breast has unique clinicopathologic characteristics, compared to invasive ductal carcinoma. The role of the 21-gene Recurrence Score (RS) has not been clearly defined for ILC. We sought to determine the prognostic value of RS and the impact of adjuvant chemotherapy on long-term survival in patients with ILC. METHODS: Utilizing the Surveillance, Epidemiology and End Results database from 2004 to 2013, we identified records of women aged 18-74 years, diagnosed with estrogen receptor (ER)-positive ILC (stage I to III) with RS available...
June 24, 2017: Breast Cancer Research and Treatment
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