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https://www.readbyqxmd.com/read/28944952/bypassing-agent-prophylaxis-in-people-with-hemophilia-a-or-b-with-inhibitors
#1
REVIEW
Chatree Chai-Adisaksopha, Sarah J Nevitt, Mindy L Simpson, Maissaa Janbain, Barbara A Konkle
BACKGROUND: People with hemophilia A or B with inhibitors are at high risk of bleeding complications. Infusion of bypassing agents, such as recombinant activated FVII (rFVIIa) and plasma-derived activated prothrombin complex concentrate, are suggested as alternative therapies to factor VIII (haemophilia A) or IX (haemophilia B) for individuals who no longer respond to these treatments because they develop inhibitory antibodies. The ultimate goal of treatment is to preserve the individual's joints, otherwise destroyed by recurrent bleeds...
September 25, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28944249/return-to-play-following-shoulder-stabilization-a-systematic-review-and-meta-analysis
#2
REVIEW
Marc N Ialenti, Jeffrey D Mulvihill, Max Feinstein, Alan L Zhang, Brian T Feeley
BACKGROUND: Anterior shoulder instability can be a disabling condition for the young athlete; however, the best surgical treatment remains controversial. Traditionally, anterior shoulder instability was treated with open stabilization. More recently, arthroscopic repair of the Bankart injury with suture anchor fixation has become an accepted technique. HYPOTHESIS: No systematic reviews have compared the rate of return to play following arthroscopic Bankart repair with suture anchor fixation with the Bristow-Latarjet procedure and open stabilization...
September 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28943899/surgical-management-of-pelvic-ewing-s-sarcoma-in-children-and-adolescents
#3
Hongbin Fan, Zheng Guo, Jun Fu, Xiangdong Li, Jing Li, Zhen Wang
The present study describes a novel surgical strategy used to treat immature pelvic Ewing's sarcoma (ES), one made possible owing to the intrinsic structure of the skeletally immature pelvis. A total of 12 children and adolescents with open triradiate cartilage received limb-salvage surgeries following a diagnosis of pelvic ES. In total, 3 patients with iliac lesions (2 lesions with extension into the sacrum) received surgical tumor excisions and allograft reconstructions. Another 8 patients with periacetabular lesions received trans-acetabular osteotomies and allograft reconstructions...
October 2017: Oncology Letters
https://www.readbyqxmd.com/read/28943457/clinical-staging-of-fibrodysplasia-ossificans-progressiva-fop
#4
Robert J Pignolo, Frederick S Kaplan
Fibrodyplasia ossificans progressiva (FOP) is an ultra-rare genetic condition of heterotopic ossification (HO) that results in progressive loss of joint function, ultimately rendering movement impossible. Death is most commonly the result of thoracic insufficiency syndrome, or complications related to recurrent respiratory infections. There are no current treatments for FOP, but early and emerging clinical trials offer hope for this devastating disease. With the recent reporting of a comprehensive global natural history study, scales to assess joint dysfunction, and a more accurate prediction of joint survival, it is now possible to construct a conceptual framework for the clinical staging of FOP...
September 21, 2017: Bone
https://www.readbyqxmd.com/read/28943370/posterior-urethroplasty-complexity-and-prognosis-can-be-described-by-a-novel-method-posterior-urethral-stenosis-score
#5
Lin Wang, Xiangguo Lv, Chongrui Jin, Hailin Guo, Huiquan Shu, Qiang Fu, Yinglong Sa
OBJECTIVE: To develop a standardized PU-score (posterior urethral stenosis score), with the goal of using this scoring system as a preliminary predictor of surgical complexity and prognosis of posterior urethral stenosis. PATIENTS AND METHODS: We retrospectively reviewed records of all patients who underwent posterior urethral surgery at our institution from 2013 to 2015. The PU-score is based on five components, namely etiology (1 or 2 points), location (1 to 3 points), length (1 to 3 points), urethral fistula (1 or 2 points) and posterior urethral false passage (1 point)...
September 21, 2017: Urology
https://www.readbyqxmd.com/read/28942026/posterolateral-fusion-versus-dynesys-%C3%A2-dynamic-stabilization-retrospective-study-at-a-minimum-5-5-years-follow-up
#6
Simon Bredin, Olivier Demay, Christophe Mensa, Karim Madi, Xavier Ohl
INTRODUCTION: Lumbar fusion is one of the most widespread techniques to treat degenerative lumbar pathology. To prevent complications such as non-union or adjacent segment degeneration, dynamic stabilization techniques were developed, but with controversial results. The aim of the present study was to compare long-term radiologic and clinical results between fusion and dynamic stabilization. MATERIAL AND METHODS: A single-center retrospective study included patients with recurrent lumbar discal hernia or lumbar canal stenosis managed by posterolateral fusion or by dynamic stabilization associated to neurologic release...
September 20, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28941923/validation-of-gemcap-as-a-dna-based-biomarker-to-predict-prostate-cancer-recurrence-after-radical-prostatectomy
#7
Hao G Nguyen, Christopher Welty, Karla Lindquist, Vy Ngo, Elizabeth Gilbert, Henrik Bengtsson, Cristina Magi-Galluzzi, Jerome Jean-Gilles, Jorge Yao, Matthew Cooperberg, Edward Messing, Eric A Klein, Peter R Carroll, Pamela L Paris
PURPOSE: We aim to validate the Genomic Evaluators of Metastatic Cancer of the Prostate (GEMCaP) as a novel copy number signature predictive for prostate cancer recurrence. MATERIALS AND METHODS: We randomly selected patients who had radical prostatectomy at the Cleveland Clinic (CC) or the University of Rochester (UR) from 2000-2005. DNA isolated from the cancer region was extracted and subjected to high resolution array comparative genomic hybridization (aCGH)...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28941919/local-tumor-bed-recurrence-following-partial-nephrectomy-in-patients-with-small-renal-masses
#8
Erika L Wood, Mehrad Adibi, Wei Qiao, Jessica Brandt, Miao Zhang, Pheroze Tamboli, Surena F Matin, Christopher G Wood, Jose A Karam
PURPOSE: To examine the incidence, characteristics, and management of patients who had tumor bed recurrence after partial nephrectomy. PATIENTS AND METHODS: We retrospectively reviewed the charts of 2,256 patients with sporadic small renal masses undergoing partial nephrectomy between 2000 and 2014. Local tumor bed recurrence was strictly defined as either: 1) detection of a new enhancing lesion specifically within the surgical defect or 2) detection of a new enhancing lesion within the same region (e...
September 20, 2017: Journal of Urology
https://www.readbyqxmd.com/read/28940998/more-than-just-side-effects-the-role-of-clinical-and-psychosocial-factors-in-non-adherence-to-tamoxifen
#9
Zoe Moon, Rona Moss-Morris, Myra S Hunter, Lyndsay D Hughes
OBJECTIVES: Tamoxifen non-adherence is apparent in up to half of breast cancer survivors and is associated with increased risk of recurrence and reduced quality of life. However, factors contributing to non-adherence in this population are currently poorly understood. This study explored the relationship between key components of the Common Sense Model of Illness Representations (CSM)/the Theory of Planned Behaviour (TPB) and intentional and unintentional non-adherence in a large sample of women prescribed tamoxifen following primary breast cancer...
September 22, 2017: British Journal of Health Psychology
https://www.readbyqxmd.com/read/28940446/the-pd-1-and-pd-l1-pathway-in-recurrent-respiratory-papillomatosis
#10
Julie Ahn, Justin A Bishop, Richard B S Roden, Clint T Allen, Simon R A Best
OBJECTIVES/HYPOTHESIS: Generation of an immunosuppressive microenvironment may enable a persistent human papillomavirus infection in the setting of an otherwise normal immune system. We hypothesized that expression of the T-lymphocyte co-inhibitory receptor programmed death 1 (PD-1) and its ligand PD-L1 would be increased in the recurrent respiratory papillomatosis (RRP) microenvironment compared to normal controls. STUDY DESIGN: Case-control study. METHODS: Formalin-fixed paraffin-embedded respiratory papilloma and normal controls were obtained under institutional review board approval, stained for CD4, CD8, FoxP3, and PD-1, and scored by automated cell count...
September 22, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28940257/timing-of-disease-occurrence-and-hepatic-resection-on-long-term-outcome-of-patients-with-neuroendocrine-liver-metastasis
#11
Xu-Feng Zhang, Eliza W Beal, Matthew Weiss, Luca Aldrighetti, George A Poultsides, Todd W Bauer, Ryan C Fields, Shishir K Maithel, Hugo P Marques, Timothy M Pawlik
BACKGROUND AND OBJECTIVES: The objective of the study was to evaluate the impact of timing of disease occurrence and hepatic resection on long-term outcome of neuroendocrine liver metastasis (NELM). METHODS: A total of 420 patients undergoing curative-intent resection for NELM were identified from a multi-institutional database. Date of primary resection, NELM detection and resection, intraoperative details, disease-specific (DSS), and recurrence-free survival (RFS) were obtained...
September 20, 2017: Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28939450/prediction-of-recurrent-clostridium-difficile-infection-at-the-bedside-the-geih-cdi-score
#12
Javier Cobo, Esperanza Merino, Cristina Martínez, Alberto Cózar-Llistó, Evelyn Shaw, Teresa Marrodán, Esther Calbo, Elena Bereciartúa, Luis A Sánchez-Muñoz, Miguel Salavert, M Teresa Pérez-Rodríguez, Dácil García-Rosado, J María Bravo-Ferrer, Juan Gálvez-Acebal, César Henríquez-Camacho, Jordi Cuquet, Berta Pino-Calm, Luis Torres, Antonio Sánchez-Porto, Borja M Fernández-Félix
Recurrence of Clostridium difficile infection (CDI) has major consequences for both patients and the health system. The ability to predict which patients are at an increased risk of recurrent CDI makes it possible to select candidates for therapy with new drugs and therapies (including fecal microbiota transplantation) that have proven to reduce the incidence of recurrence of CDI. Our objective was to develop a clinical prediction tool, the GEIH-CDI score, to determine the risk of recurrence of CDI. Predictors of recurrence of CDI were investigated using logistic regression in a prospective cohort of 274 patients diagnosed with CDI...
September 19, 2017: International Journal of Antimicrobial Agents
https://www.readbyqxmd.com/read/28939426/the-semmes-weinstein-monofilament-examination-for-predicting-physical-performance-and-the-risk-of-falls-in-older-people-results-from-the-pro-v-a-longitudinal-study
#13
Pamela Carrer, Caterina Trevisan, Chiara Curreri, Valter Giantin, Stefania Maggi, Gaetano Crepaldi, Enzo Manzato, Giuseppe Sergi
OBJECTIVES: to investigate whether Semmes Weinstein Monofilament Examination (SWME) was associated with, and could predict measures of physical performance and the risk of fall in elderly subjects. DESIGN: prospective study (mean follow-up 4.4-years). SETTING: community. SUBJECTS: 2826 older subjects enrolled in the Progetto Veneto Anziani (Pro.V.A.), an Italian population-based cohort study. For longitudinal analyses, we considered a subsample of 1885 persons who did not report falls at baseline...
September 19, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28939178/prostate-cancer-post-prostatectomy-radiotherapy-ct-vs-mri-for-vesico-urethral-anastomosis-target-delineation
#14
Daryl Lim Joon, Adeline Lim, Michal Schneider, Chee-Yan Hiew, Nathan Lawrentschuk, Shomik Sengupta, Farshad Foroudi, Trish Jenkins, David Angus, Morikatsu Wada, Michael Chao, Vincent Khoo
BACKGROUND: Vesico-urethral anastomosis (VUA) is critical to the clinical target volume (CTV) in post-prostatectomy radiotherapy (PPRT), as it is the commonest site of recurrence. Typically, this is performed on a CT alone but guidelines recommend MRI. OBJECTIVE: To evaluate the VUA spatial differences between CT (ctVUA) and MRI (mrVUA) and analyse its impact on the CT defined CTV (ctCTV) as recommended by published guidelines. MATERIALS AND METHODS: We identified 34 patients with a co-registered simulation CT and T2 weighted MRI...
September 19, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28938489/prognostic-classifier-based-on-genome-wide-dna-methylation-profiling-in-well-differentiated-thyroid-tumors
#15
Mariana Bisarro Dos Reis, Mateus Camargo Barros-Filho, Fábio Albuquerque Marchi, Caroline Moraes Beltrami, Hellen Kuasne, Clóvis Antônio Lopes Pinto, Srikant Ambatipudi, Zdenko Herceg, Luiz Paulo Kowalski, Silvia Regina Rogatto
Context: Even though the majority of well-differentiated thyroid cancer (WDTC) is indolent, a number of cases display an aggressive behavior. Cumulative evidences have suggested that the deregulation of DNA methylation has the potential to point out molecular markers associated with worse prognosis. Objective: To identify a prognostic epigenetic signature in thyroid cancer. Design: Genome-wide DNA methylation assays (450k platform, Illumina) were performed in a cohort of 50 non-neoplastic thyroid tissues (NT), 17 benign thyroid lesions (BTL) and 74 thyroid carcinomas (60 papillary, 8 follicular, 2 Hürthle cell, 1 poorly differentiated and 3 anaplastic)...
August 16, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/28938393/ilizarov-treatment-protocols-in-the-management-of-infected-nonunion-of-the-tibia
#16
Martin McNally, Jamie Ferguson, Raj Kugan, David Stubbs
OBJECTIVES: We present a treatment algorithm comprising 4 Ilizarov methods in managing infected tibial nonunion, using nonunion mobility and segmental defect size to govern treatment choice. DESIGN: Decision protocol analysis study. SETTING: A university-affiliated teaching hospital. PATIENTS/PARTICIPANTS: Seventy-nine patients were treated with 1 of 4 Ilizarov protocols. All patients had undergone at least one previous operation, 38 had associated limb deformity, and 49 had nonviable nonunions...
October 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28937455/palliative-surgery-for-spinal-metastases-using-posterior-decompression-and-fixation-combined-with-intraoperative-vertebroplasty
#17
Liang Dong, Mingsheng Tan, Di Wu, Ping Yi, Feng Yang, Xiangsheng Tang, Qingying Hao
STUDY DESIGN: Retrospective study. OBJECTIVE: To evaluate the clinical outcome of palliative surgery using posterior decompression and fixation combined with intraoperative vertebroplasty (PDFIV) for the treatment of spinal metastases, and analyze the indications for PDFIV using a neurological, oncologic, mechanical, and systemic framework. SUMMARY OF BACKGROUND DATA: Palliative surgery is widely used to spinal metastatic patients with poor condition for enough postoperative recovery...
October 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28936153/management-and-treatment-recommendations-for-world-health-organization-grade-iii-and-iv-gliomas
#18
REVIEW
Abdullah K Altwairgi, Shanker Raja, Mohammed Manzoor, Sadeq Aldandan, Eyad Alsaeed, Ali Balbaid, Hussain Alhussain, Yassir Orz, Ahmed Lary, Abdullah A Alsharm
The treatment recommendations provided in this manuscript are intended to serve as a knowledge base for clinicians and health personals involved in treating patients with high-grade malignant glioma. In newly diagnosed patients, complete resection or biopsy is required for histological characterization of the tumor, which in turn is essential to decide the treatment strategy. In patients with good or borderline performance score, radiotherapy (RT), and chemotherapy are the preferred management. In patients with poor performance score, RT with best possible supportive care is the mainstay of the management...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28936145/efficacy-and-safety-of-short-pulse-erbium-yttrium-aluminum-garnet-laser-treatment-of-becker-s-nevus-in-saudi-patients-a-pilot-study
#19
Fahad Al-Saif, E Al-Mekhadab, H Al-Saif
OBJECTIVE: Becker's nevus (BN) is a benign cutaneous hamartoma. Although different types of lasers have been used to treat the pigmentary part of BN, to date, no definite treatment modality has been determined. The objective of this study is to evaluate the efficacy and safety of erbium: yttrium aluminum garnet (Er: YAG) laser treatment among Saudi patients with BN. PATIENTS AND METHODS: A series of 10 patients (skin phototypes III-V) with BN underwent treatment with an Er: YAG laser...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28934968/comparison-of-volumetric-modulated-arc-therapy-using-simultaneous-integrated-boosts-sib-vmat-of-45%C3%A2-gy-55%C3%A2-gy-in-25-fractions-with-conventional-radiotherapy-in-preoperative-chemoradiation-for-rectal-cancers-a-propensity-score-case-matched-analysis
#20
Hideomi Yamashita, Soichiro Ishihara, Hiroaki Nozawa, Kazushige Kawai, Tomomichi Kiyomatsu, Kae Okuma, Osamu Abe, Toshiaki Watanabe, Keiichi Nakagawa
BACKGROUND AND PURPOSE: The aim of this retrospective study was to compare volumetric-modulated arc therapy using simultaneous integrated boosts (SIB-VMAT) of 45 Gy/55 Gy in 25 fractions with three-dimensional conformal radiotherapy (3D-CRT) in preoperative chemoradiation for rectal cancers. METHODS AND MATERIALS: In the propensity score-matching analysis of 1:2, we selected 60 patients from the SIB-VMAT group and 120patients from the 3D-CRT group matched pairings out of 145 patients between 2005 and 2015...
September 21, 2017: Radiation Oncology
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