Marina Mendiburu-Eliçabe, Natalia García-Sancha, Roberto Corchado-Cobos, Angélica Martínez-López, Hang Chang, Jian Hua Mao, Adrián Blanco-Gómez, Ana García-Casas, Andrés Castellanos-Martín, Nélida Salvador, Alejandro Jiménez-Navas, Manuel Jesús Pérez-Baena, Manuel Adolfo Sánchez-Martín, María Del Mar Abad-Hernández, Sofía Del Carmen, Juncal Claros-Ampuero, Juan Jesús Cruz-Hernández, César Augusto Rodríguez-Sánchez, María Begoña García-Cenador, Francisco Javier García-Criado, Rodrigo Santamaría Vicente, Sonia Castillo-Lluva, Jesús Pérez-Losada
BACKGROUND: Luminal A tumours generally have a favourable prognosis but possess the highest 10-year recurrence risk among breast cancers. Additionally, a quarter of the recurrence cases occur within 5 years post-diagnosis. Identifying such patients is crucial as long-term relapsers could benefit from extended hormone therapy, while early relapsers might require more aggressive treatment. METHODS: We conducted a study to explore non-structural chromosome maintenance condensin I complex subunit H's (NCAPH) role in luminal A breast cancer pathogenesis, both in vitro and in vivo, aiming to identify an intratumoural gene expression signature, with a focus on elevated NCAPH levels, as a potential marker for unfavourable progression...
February 2024: Clinical and Translational Medicine