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https://www.readbyqxmd.com/read/29774599/deep-convolutional-neural-network-for-segmentation-of-knee-joint-anatomy
#1
Zhaoye Zhou, Gengyan Zhao, Richard Kijowski, Fang Liu
PURPOSE: To describe and evaluate a new segmentation method using deep convolutional neural network (CNN), 3D fully connected conditional random field (CRF), and 3D simplex deformable modeling to improve the efficiency and accuracy of knee joint tissue segmentation. METHODS: A segmentation pipeline was built by combining a semantic segmentation CNN, 3D fully connected CRF, and 3D simplex deformable modeling. A convolutional encoder-decoder network was designed as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification for 12 different joint structures...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29773398/sulfated-polysaccharide-mediated-tgf-%C3%AE-1-presentation-in-pre-formed-injectable-scaffolds-for-cartilage-tissue-engineering
#2
Neha Ashok Waghmare, Aditya Arora, Arijit Bhattacharjee, Dhirendra S Katti
In this work, a plant-derived polysaccharide carboxymethylcellulose (CMC) was chemically modified to incorporate sulfate groups to facilitate binding of cationic growth factors. The sulfated CMC (heparin mimic) was then used with CMC (glycosaminoglycan mimic) and gelatin (collagen mimic) to fabricate injectable pre-formed, macroporous scaffolds for cartilage tissue engineering. These scaffolds demonstrated high resilience and shape memory, thereby making them injectable through a 14G needle for up to 4-6 aspiration and injection cycles...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29769086/inflammatory-pattern-of-the-infrapatellar-fat-pad-in-dogs-with-canine-cruciate-ligament-disease
#3
Manuel R Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E Spreng, Simone Forterre
BACKGROUND: Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthritis, the infrapatellar fat pad (IFP) was up to now mostly disregarded in veterinary investigations. In the present study, the inflammatory activity of the IFP, the main adipose structure within the stifle joint, was thoroughly investigated to evaluate its potential impact in the pathogenesis of this common disease of our canine companions...
May 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29765886/reference-value-for-infrapatellar-branch-of-saphenous-nerve-conduction-study-cadaveric-and-clinical-study
#4
Keon-Tae Kim, Yong-Ki Kim, Jung Ro Yoon, Yundam Ko, Myung Eun Chung
Objective: To determine the optimal stimulation and recording site for infrapatellar branch of saphenous nerve (IPBSN) conduction studies by a cadaveric study, and to confirm that obtained location is practically applicable to healthy adults. Methods: Twelve lower limbs from six cadavers were studied. We defined the optimal stimulation site as the point IPBSN exits the sartorius muscle and the distance or ratio were measured on the X- and Y-axis based on the line connecting the medial and lateral poles of the patella...
April 2018: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/29765427/adipose-derived-mesenchymal-stem-cells-in-the-use-of-cartilage-tissue-engineering-the-need-for-a-rapid-isolation-procedure
#5
REVIEW
Sam L Francis, Serena Duchi, Carmine Onofrillo, Claudia Di Bella, Peter F M Choong
Mesenchymal stem cells (MSCs) have shown much promise with respect to their use in cartilage tissue engineering. MSCs can be obtained from many different tissue sources. Among these, adipose tissue can provide an abundant source of adipose-derived mesenchymal stem cells (ADMSCs). The infrapatellar fat pad (IFP) is a promising source of ADMSCs with respect to producing a cartilage lineage. Cell isolation protocols to date are time-consuming and follow conservative approaches that rely on a long incubation period of 24-48 hours...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29761471/the-infrapatellar-fat-pad-and-the-synovial-membrane-an-anatomo-functional-unit
#6
REVIEW
Veronica Macchi, Elena Stocco, Carla Stecco, Elisa Belluzzi, Marta Favero, Andrea Porzionato, Raffaele De Caro
The infrapatellar pad, a fibro-adipose tissue with peculiar microscopic and mechanical features, is gaining wide attention in the field of rheumatological research. The purpose of this descriptive review is to summarize the most recent published evidence on the anatomic, physiologic and biomechanical inter-relationship between the infrapatellar fat pad and the knee synovial membrane. As an extrasynovial tissue, the infrapatellar fat pad does not directly interact with the articular cartilage; based on its location in close contact with the synovial membrane, and due to the metabolic properties of adipose tissue, it may influence the behavior of the synovial membrane...
May 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29753949/associations-between-knee-structural-measures-circulating-inflammatory-factors-and-mmp13-in-patients-with-knee-osteoarthritis
#7
Guangfeng Ruan, Jianhua Xu, Kang Wang, Juan Wu, Qicui Zhu, Jiale Ren, Fuqin Bian, Bingru Chang, Xiaochun Bai, Weiyu Han, Changhai Ding
OBJECTIVE: To investigate cross-sectional associations between serum level of MMP13 and knee structural measures and circulating inflammatory factors in patients with symptomatic knee osteoarthritis (OA). DESIGN: A total of 149 subjects with symptomatic knee OA were included. Magnetic resonance imaging was used to measure infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage volume and cartilage defects. Knee radiography was used to assess radiographic OA using the Kellgren-Lawrence (K-L) grading system...
May 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29748692/clinics-in-diagnostic-imaging-185
#8
Ying Xin Candice Leong, Poh Lye Paul See
A 20-year-old National Serviceman presented with left knee pain and swelling after training for his physical fitness test. Lateral knee radiography and magnetic resonance (MR) imaging showed patellar tendon-lateral femoral condyle friction syndrome (PT-LFCFS), on a background of patella alta and patellar malalignment. The patient was treated non-operatively with a course of physiotherapy and given advice on rest and activity modification. PT-LFCFS is a less well-recognised but important cause of anterior knee pain and represents an entity in a spectrum of disorders related to patellofemoral instability...
April 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29698461/induction-of-osteoarthritis-by-injecting-monosodium-iodoacetate-into-the-patellofemoral-joint-of-an-experimental-rat-model
#9
Ikufumi Takahashi, Taro Matsuzaki, Hiroshi Kuroki, Masahiro Hoso
This study aimed to investigate the histopathological changes in the patellofemoral joint using a rat model of osteoarthritis that was induced using monosodium iodoacetate, and to establish a novel model of patellofemoral osteoarthritis in a rat model using histopathological analysis. Sixty male rats were used. Osteoarthritis was induced through a single intra-articular injection of monosodium iodoacetate in both knee joints. Animals were equally divided into two experimental groups based on the monosodium iodoacetate dose: 0...
2018: PloS One
https://www.readbyqxmd.com/read/29695173/conditioned-media-from-human-osteoarthritic-synovium-induces-inflammation-in-a-synoviocyte-cell-line
#10
Elisa Belluzzi, Eleonora Olivotto, Giovanna Toso, Augusto Cigolotti, Assunta Pozzuoli, Carlo Biz, Giovanni Trisolino, Pietro Ruggieri, Brunella Grigolo, Roberta Ramonda, Marta Favero
AIM: Osteoarthritis (OA) is a whole joint pathology involving cartilage, synovial membrane, meniscus, subchondral bone and infrapatellar fat pad (IFP). Synovitis has been widely documented in OA suggesting its important role in pathogenesis. The aim of this study was to investigate the role of different joint tissues in promoting synovitis. MATERIALS AND METHODS: Conditioned media (CM) from cartilage, synovial membrane, meniscus and IFP, were generated from tissues of five patients undergoing total knee replacement and used to stimulate a human fibroblast-like synoviocytes cell line (K4IM)...
April 26, 2018: Connective Tissue Research
https://www.readbyqxmd.com/read/29679117/the-infrapatellar-fat-pad-is-a-dynamic-and-mobile-structure-which-deforms-during-knee-motion-and-has-proximal-extensions-which-wrap-around-the-patella
#11
Joanna M Stephen, Ran Sopher, Sebastian Tullie, Andrew A Amis, Simon Ball, Andy Williams
PURPOSE: The infrapatellar fat pad (IFP) is a common cause of knee pain and loss of knee flexion and extension. However, its anatomy and behavior are not consistently defined. METHODS: Thirty-six unpaired fresh frozen knees (median age 34 years, range 21-68) were dissected, and IFP attachments and volume measured. The rectus femoris was elevated, suprapatellar pouch opened and videos recorded looking inferiorly along the femoral shaft at the IFP as the knee was flexed...
April 20, 2018: Knee Surgery, Sports Traumatology, Arthroscopy: Official Journal of the ESSKA
https://www.readbyqxmd.com/read/29668497/surgical-treatment-of-venous-malformations-of-the-knee-treatment-outcomes-for-35-patients
#12
Claude Laurian, Claudine Masonni, Michel Wassef, Emmanuel Houdart, Francesca Toni, Veronique Marteau, Nikos Paraskevas, Stephanie Lenck, Annouk Bisdorff
BACKGROUND: The place of open surgery in venous malformations (VMs) of knee joint is still discussed. The aim of this study was to evaluate the benefits of surgery in terms of pain, function, and quality of life. DESIGN: This was a retrospective observational study. METHODS: Thirty-five consecutive young patients undergoing surgery for VMs of the knee between 2011 and 2014 were included. Data collection was performed using a prospective database by reviewing patient records...
April 17, 2018: Journal of Pediatric Orthopedics
https://www.readbyqxmd.com/read/29667940/the-importance-of-the-saphenous-nerve-block-for-analgesia-following-major-ankle-surgery-a-randomized-controlled-double-blind-study
#13
Siska Bjørn, Wan Yi Wong, Jørgen Baas, Kristian K Nielsen, Jens Børglum, Rasmus Wulff Hauritz, Thomas Fichtner Bendtsen
BACKGROUND AND OBJECTIVES: Major ankle surgery causes intense postoperative pain, and whereas the importance of a sciatic nerve block is well established, the clinical significance of a supplemental saphenous nerve block has never been determined in a prospective, randomized, double-blind, placebo-controlled trial. We hypothesized that a saphenous nerve block reduces the proportion of patients experiencing significant clinical pain after major ankle surgery. METHODS: Eighteen patients were enrolled and received a popliteal sciatic nerve block...
March 26, 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29652075/impact-of-tgf-%C3%AE-family-related-growth-factors-on-chondrogenic-differentiation-of-adipose-derived-stem-cells-isolated-from-lipoaspirates-and-infrapatellar-fat-pads-of-osteoarthritic-patients
#14
E López-Ruiz, G Jiménez, W Kwiatkowski, E Montañez, F Arrebola, E Carrillo, S Choe, J A Marchal, M Perán
The success of cell-based approaches for the treatment of cartilage defects requires an optimal autologous cell source with chondrogenic differentiation ability that maintains its differentiated properties and stability following implantation. The objective of this study was to compare the chondrogenic capacity of mesenchymal stem cells (MSCs) isolated from lipoaspirates (ASCs) and the infrapatellar fat pad (IFPSCs) of osteoarthritic patients and treated with transforming growth factor (TGF)-β family-related growth factors...
April 13, 2018: European Cells & Materials
https://www.readbyqxmd.com/read/29648688/quantitative-signal-intensity-alteration-in-infrapatellar-fat-pad-predict-incident-radiographic-osteoarthritis-the-osteoarthritis-initiative
#15
Kang Wang, Changhai Ding, Michael J Hannon, Zhongshan Chen, C Kent Kwoh, David J Hunter
OBJECTIVES: To determine if infrapatellar fat pad (IPFP) signal intensity (SI) measures are predictive of incident radiographic osteoarthritis (iROA) over 4 years in the OA Initiative (OAI) study. METHODS: Case knees (n=355) defined by iROA were matched one-to-one by gender, age and radiographic status with control knees. T2-weighted MR images were assessed at P0 (the visit when iROA was found on radiograph), P-1 (1 year prior to P0) and baseline, and utilized to assess IPFP SI semi-automatically using MATLAB...
April 12, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29578044/systemic-and-local-adipose-tissue-in-knee-osteoarthritis
#16
REVIEW
J Chang, Z Liao, M Lu, T Meng, W Han, C Ding
Knee osteoarthritis (OA) is the most common joint disease. Body adipose tissue has been shown to be related to the development and progression of knee OA. Among systemic adipose tissues, subcutaneous adipose tissue is significantly and negatively associated with muscle mass and forces, and could be related to the presence and progression of knee OA. Visceral adipose tissue is associated with increased cartilage loss and production of pro-inflammatory cytokines. Intra-muscular adipose tissue is associated with knee osteoarthritic changes, but it remains controversial if inter-muscular adipose tissue has a role to play in the pathogenesis for knee OA...
March 22, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29570766/arthroscopic-repair-of-chronic-tears-of-the-anterior-horn-of-the-lateral-meniscus-that-includes-covering-the-lesion-with-an-infrapatellar-pedicle-fat-flap
#17
Zhu Dai, Zhiwei Chen, Ying Liao, Zhengwu Tang, Juncheng Cui, Zhibin Tang
This study analyzed the efficacy and safety of arthroscopic outside-in repair of the anterior horn of the lateral meniscus that includes covering the lesion with an infrapatellar pedicle fat flap in patients with chronic tears. This retrospective study reviewed 87 patients with chronic tears of the anterior horn of the lateral meniscus who underwent arthroscopic outside-in repair, which included covering the lesion with an infrapatellar pedicle fat flap (group A, n=45) or not (group B, n=42). The 2 groups were similar in terms of age, sex, body mass index, and disease duration...
March 23, 2018: Orthopedics
https://www.readbyqxmd.com/read/29557887/anatomical-study-of-the-innervation-of-anterior-knee-joint-capsule-implication-for-image-guided-intervention
#18
John Tran, Philip W H Peng, Karen Lam, Ehtesham Baig, Anne M R Agur, Michael Gofeld
BACKGROUND AND OBJECTIVES: The knee joint is the most common site of osteoarthritis. While joint replacement is considered an ultimate solution, radiofrequency denervation may be contemplated in some cases. Radiofrequency ablation requires precise localization of the articular branches innervating the joint capsule. The objective of this cadaveric study was to determine the source, course, relationships, and frequency of articular branches innervating the anterior knee joint capsule. METHODS: Fifteen knees were meticulously dissected...
May 2018: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/29554720/infrapatellar-fat-pad-derived-stem-cell-based-regenerative-strategies-in-orthopedic-surgery
#19
REVIEW
Pinar Yilgor Huri, Seren Hamsici, Emre Ergene, Gazi Huri, Mahmut Nedim Doral
Infrapatellar fat pad is a densely vascularized and innervated extrasynovial tissue that fills the anterior knee compartment. It plays a role in knee biomechanics as well as constitutes a source of stem cells for regeneration after knee injury. Infrapatellar fat pad-derived stem cells (IPFP-ASCs) possess enhanced and age-independent differentiation capacity as compared to other stem cells, which makes them a very promising candidate in stem cell-based regenerative therapy. The aims of this review are to outline the latest advances and potential trends in using IPFP-ASCs and to emphasize the advantages over other sources of stem cells for applications in orthopedic surgery...
March 19, 2018: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29526161/tumors-and-tumor-like-lesions-of-infrapatellar-fat-pad-and-surrounding-tissues-a-review-of-the-literature
#20
Erdem Aras Sezgin, O Şahap Atik
The infrapatellar fat pad (IFP) is an intracapsular structure with critical importance both mechanically and endocrinologically. Its dysfunction must be considered while clinically investigating the symptoms arising from the knee joint. Infrapatellar fat pad may be subject to trauma, impingement, inflammation or tumoral formations. Although tumors arising within or adjacent to IFP are not extremely rare, the literature can only provide limited information about them. This article aims to briefly review the current literature on tumors and tumor-like lesions of the IFP and surrounding tissues; focusing on diagnosis and treatment management...
April 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
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