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https://www.readbyqxmd.com/read/28906305/risk-of-knee-sepsis-following-treatment-of-open-tibia-fractures-a-multicenter-comparison-of-suprapatellar-and-infrapatellar-approaches
#1
Geoffrey S Marecek, Luke T Nicholson, Frances H Broghammer, Michael Talerico, Caroline Tougas, Derek J Donegan, John A Scolaro
OBJECTIVES: The suprapatellar approach for medullary nailing of the tibia is increasing. This requires intra-articular passage of instruments, which theoretically places the knee at risk for postoperative sepsis in the setting of open fracture. We hypothesized that the risk of knee sepsis is similar after suprapatellar or infrapatellar nailing of open tibia fractures. DESIGN: Retrospective, multicenter. SETTING: Three urban Level-1 trauma centers PATIENTS:: All patients treated with medullary nailing for open diaphyseal tibia fractures (OTA 42) from 2009 to 2015...
September 11, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28888527/complications-following-harvesting-of-patellar-tendon-or-hamstring-tendon-grafts-for-anterior-cruciate-ligament-reconstruction-systematic-review-of-literature
#2
REVIEW
A Hardy, L Casabianca, K Andrieu, L Baverel, T Noailles
INTRODUCTION: Anterior cruciate ligament (ACL) reconstruction can be performed with an autograft, which is most often harvested from the patient's hamstring tendon (HT) or patellar tendon (PT). However, autograft harvesting leads to morbidity that is by no means insignificant.A systematic review of literature was performed to define the incidence of complications related to graft harvesting and the methods to prevent these complications. MATERIALS AND METHODS: In March 2017, a systemic review of literature was performed using the keywords"harvesting", "harvest", "morbidity", "complication", "cruciate ligament"...
September 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28888201/tgf-%C3%AE-1-presenting-enzymatically-cross-linked-injectable-hydrogels-for-improved-chondrogenesis
#3
Aditya Arora, Aman Mahajan, Dhirendra S Katti
In this work, we developed a novel enzymatically cross-linked injectable hydrogel composed of carboxymethyl cellulose (CMC), sulfated carboxymethyl cellulose (sCMC) and gelatin for delivery of infrapatellar fat pad derived MSCs and articular chondrocytes to a cartilage defect site while enabling TGF-β1 mediated chondrogenesis. The sCMC component in the hydrogel served the purpose of mimicking heparan sulfate and thus enabled strong binding with TGF-β1 and its consequential long term presentation to the encapsulated cells...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28859260/reply-to-the-letter-to-editor-by-macchi-et-al
#4
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, Hamish Simpson
We thank Macchi et al. for their comments regarding our study describing regional differences between perisynovial and infrapatellar adipose tissue (AT) depots in patients with end stage osteoarthritis (OA) of the knee [1]. They summarize our findings concisely and contextualize this data with their own findings. The main goal of our paper was to quantify the differences between synovial and infrapatellar fat pad (IPFP) AT deposits from the same patient. The synovial AT had more pro-inflammatory/pro-fibrotic response than the IPFP in patients with obesity...
August 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28855693/rheumatoid-arthritis-characterization-of-the-infrapatellar-fat-pad
#5
Liesbet Lieben
No abstract text is available yet for this article.
August 31, 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28841726/incidence-and-characterization-of-hypoesthesia-in-the-distribution-of-the-infrapatellar-branch-of-the-saphenous-nerve-after-anterior-cruciate-ligament-reconstruction-a-prospective-study-of-patient-reported-numbness
#6
Steven Brad Cohen, Russell Flato, Jocelyn Wascher, Ryan Watson, Matthew Salminen, Daniel O'Brien, Fotios Tjoumakaris, Michael Ciccotti
No abstract text is available yet for this article.
August 25, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28831763/relationship-between-magnetic-resonance-imaging-findings-radiological-grading-psychological-distress-and-pain-in-patients-with-symptomatic-knee-osteoarthritis
#7
Marina Carotti, Fausto Salaffi, Marco Di Carlo, Andrea Giovagnoni
BACKGROUND: Synovial hypertrophy, synovial effusions, and abnormalities in the subchondral bone play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain. Understanding and careful clinical assessment together with better imaging such as magnetic resonance imaging (MRI) of the knee may improve treatment strategies. The aim of this cross-sectional study was to investigate the associations between the structural findings on MRI (bone marrow lesions [BMLs], synovitis, cartilage defects, meniscal lesions), X-ray examination (Kellgren and Lawrence [K/L] grade), and psychological aspects with pain in patients with knee osteoarthritis (KOA)...
August 22, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28816507/arthroscopic-harvest-of-adipose-derived-mesenchymal-stem-cells-from-the-infrapatellar-fat-pad
#8
Jason L Dragoo, Wenteh Chang
BACKGROUND: The successful isolation of adipose-derived mesenchymal stem cells (ADSCs) from the arthroscopically harvested infrapatellar fat pad (IFP) would provide orthopaedic surgeons with an autologous solution for regenerative procedures. PURPOSE: To demonstrate the quantity and viability of the mesenchymal stem cell population arthroscopically harvested from the IFP as well as the surrounding synovium. STUDY DESIGN: Descriptive laboratory study...
August 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28800775/lack-of-high-bmi-related-features-in-adipocytes-and-inflammatory-cells-in-the-infrapatellar-fat-pad-ifp
#9
Anja J de Jong, Inge R Klein-Wieringa, Stefan N Andersen, Joanneke C Kwekkeboom, Linda Herb-van Toorn, Badelog J E de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J L van der Heide, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch, Annemarie M Zuurmond, Vedrana Stojanovic-Susulic, Rob G H H Nelissen, René E M Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
BACKGROUND: Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and molecular body mass index (BMI)-related features in the IFP of OA patients. METHODS: Patients with knee OA (N = 155, 68% women, mean age 65 years, mean (SD) BMI 29...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28790478/entrapment-neuropathy-of-the-infrapatellar-branch-of-the-saphenous-nerve-treated-by-partial-division-of-sartorius
#10
Gururaj Hosahalli, Adam Sierakowski, Hari Venkatramani, S Raja Sabapathy
We describe a case of entrapment neuropathy of the infrapatellar branch of the saphenous nerve as it pierces sartorius muscle. This is a rare cause of anteromedial knee pain that is easily overlooked and may be mistaken as arising from other anatomical structures in that region. The pain was successfully treated by partially dividing the sartorius muscle and translocating the nerve away from the site of entrapment. It is important to consider entrapment neuropathy of the infrapatellar branch of the saphenous nerve as a differential diagnosis when assessing a patient with anteromedial knee pain...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28770522/hoffa-s-fat-pad-abnormality-in-the-development-of-knee-osteoarthritis
#11
Wojciech Paduszyński, Mateusz Jeśkiewicz, Paweł Uchański, Sebastian Gackowski, Marek Radkowski, Urszula Demkow
Over the past two decades, many hypotheses have been put forward to explain the cause of knee osteoarthritis. Scientific reports bring up the role of adipose tissue in the activation of the inflammatory mechanisms, which is a characteristic feature of osteoarthritis natural history. Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms. Hoffa's fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators...
August 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28769981/human-suprapatellar-fat-pad-derived-mesenchymal-stem-cells-induce-chondrogenesis-and-cartilage-repair-in-a-model-of-severe-osteoarthritis
#12
Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28743142/infrapatellar-fat-pad-impingement-a-systematic-review
#13
Jason Genin, Mhamad Faour, Prem N Ramkumar, George Yakubek, Anton Khlopas, Morad Chughtai, Michael A Mont, Dominic King
No abstract text is available yet for this article.
September 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28718946/evidence-for-plical-support-of-the-patella
#14
Robert M Geraghty, Michelle Spear
There is a consensus that there is no overt anterior joint capsule in the knee. However, other anterior structures act in lieu of a joint capsule: the quadriceps tendon and patellar retinacular fibres. In the absence of a capsule, the synovium forms the suprapatellar pouch. Other synovial structures, the plicae, are more controversial. They are often described as embryonic remnants with no function, despite surrounding the patella. We aimed to identify plical anatomy and histology on cadaveric dissection and to examine their embryology using the human virtual embryo website...
July 18, 2017: Journal of Anatomy
https://www.readbyqxmd.com/read/28718060/innate-immune-responses-and-osteoarthritis
#15
REVIEW
Evangelia Kalaitzoglou, Timothy M Griffin, Mary Beth Humphrey
PURPOSE OF THE REVIEW: Osteoarthritis (OA) is a chronic, painful joint disease that affects approximately 40% of adults over 70 year. Age is the strongest predictor of OA, while obesity is considered the primary preventable risk factor for OA. Both conditions are associated with abnormal innate immune inflammatory responses that contribute to OA progression and are the focus of this review. RECENT FINDINGS: Recent studies have identified risk factors for OA progression including increased innate immune responses secondary to aging-associated myeloid skewing, obesity-related myeloid activation, and synovial tissue hyperplasia with activated macrophage infiltration...
August 2017: Current Rheumatology Reports
https://www.readbyqxmd.com/read/28655325/injury-to-infrapatellar-branch-of-saphenous-nerve-in-anterior-cruciate-ligament-reconstruction-using-vertical-skin-incision-for-hamstring-harvesting-risk-factors-and-the-influence-of-treatment-outcome
#16
Satoshi Ochiai, Tetsuo Hagino, Shinya Senga, Takashi Yamashita, Kotaro Oda, Hirotaka Haro
BACKGROUND: Injury to the infrapatellar branch of the saphenous nerve (IPBSN) is a high-frequency complication in anterior cruciate ligament (ACL) reconstruction. We analyzed the risk factor of IPBSN injury in ACL reconstruction. Moreover, we investigated the influence on treatment outcome by this complication. METHODS: One hundred twenty-three patients who underwent ACL reconstruction using semitendinosus tendon graft were studied. Gender, age, BMI, and additional use of gracilis tendon were recorded...
June 27, 2017: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/28626099/-a-cross-sectional-study-on-the-correlation-between-mri-signal-for-ipfp-and-knee-osteoarthritis
#17
Song Wu, Hongliang Ba, Jinshen He, Yunjie Liao
To investigate the correlation between MRI signal for infrapatellar fat pad (IPFP) and pathological changes in knee osteoarthritis (KOA), and to analyze the role of IPFP in the development of knee osteoarthritis.
 Methods: A total of 114 subjects (without special knee disease) were enrolled for this study. The intensity of MRI signal for IPFP was determined by fat-suppressed proton-density-weighted turbospin-echo magnetic resonance imaging. Based on the cartilage defects and osteophytes of knee joint, the subjects were divided into a KOA group and a control group...
May 28, 2017: Zhong Nan da Xue Xue Bao. Yi Xue Ban, Journal of Central South University. Medical Sciences
https://www.readbyqxmd.com/read/28602782/associations-between-serum-ghrelin-and-knee-symptoms-joint-structures-and-cartilage-or-bone-biomarkers-in-patients-with-knee-osteoarthritis
#18
J Wu, K Wang, J Xu, G Ruan, Q Zhu, J Cai, J Ren, S Zheng, Z Zhu, P Otahal, C Ding
OBJECTIVE: The roles of ghrelin in knee osteoarthritis (OA) are unclear. This study aimed to examine cross-sectional associations of ghrelin with knee symptoms, joint structures and cartilage or bone biomarkers in patients with knee OA. METHODS: This study included 146 patients with symptomatic knee OA. Serum levels of ghrelin and cartilage or bone biomarkers including cartilage oligomeric matrix protein (COMP), cross linked C-telopeptide of type I collagen (CTXI), cross linked N-telopeptide of type I collagen (NTXI), N-terminal procollagen III propeptide (PIIINP), and matrix metalloproteinase (MMP)-3, 10, 13 were measured using Enzyme-linked immunosorbent assay (ELISA)...
September 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28602535/periarticular-injections-in-knee-and-hip-arthroplasty-where-and-what-to-inject
#19
Jeremy A Ross, Anna C Greenwood, Phillip Sasser, William A Jiranek
BACKGROUND: Periarticular injections have become a valuable adjunct to multimodal pain control regimens after knee and hip arthroplasties. Injection techniques vary greatly among surgeons with little standardization of practice. METHODS: We performed an extensive literature search to determine where nociceptive pain fibers are located in the hip and the knee and also to explore the pharmacology of periarticular cocktail ingredients. RESULTS: Large concentrations of nociceptors are present throughout the various tissues of the knee joint with elevated concentrations in the infrapatellar fat pad, fibrous capsule, ligament insertions, periosteum, subchondral bone, and lateral retinaculum...
May 11, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/28601257/commentary-on-co-culture-of-infrapatellar-fat-pad-derived-mscs-and-articular-chondrocytes-in-plasma-clot-for-cartilage-tissue-engineering
#20
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