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Erdem Aras Sezgin, O Şahap Atik
The infrapatellar fat pad (IFP) is an intracapsular structure with critical importance both mechanically and endocrinologically. Its dysfunction must be considered while clinically investigating the symptoms arising from the knee joint. Infrapatellar fat pad may be subject to trauma, impingement, inflammation or tumoral formations. Although tumors arising within or adjacent to IFP are not extremely rare, the literature can only provide limited information about them. This article aims to briefly review the current literature on tumors and tumor-like lesions of the IFP and surrounding tissues; focusing on diagnosis and treatment management...
April 2018: Eklem Hastalıkları Ve Cerrahisi, Joint Diseases & related Surgery
Himabindu Mikkilineni, Patricia B Delzell, Jack Andrish, Jennifer Bullen, Nancy A Obuchowski, Naveen Subhas, Joshua M Polster, Jean P Schils
BACKGROUND: We sought to determine whether there are ultrasound parameters that differ between knees with symptomatic fat pad synovial impingement and asymptomatic knees. METHODS: A prospective study was performed in patients with clinical signs and symptoms of fat pad synovial impingement and asymptomatic controls. Eleven symptomatic knees and 10 asymptomatic controls were evaluated. Ultrasound imaging was performed before and after exercise. Evaluated parameters included largest fat lobule compressibility, subjective assessment of vascularity, largest vessel diameter, and subjective assessment of dynamic fat pad motion during flexion and extension...
March 7, 2018: Knee
Jonathan D Packer, Wen-Teh Chang, Jason L Dragoo
Background: Adipose-derived stem cell (ADSC)-based treatments have the potential to treat numerous soft-tissue pathologies. It would be beneficial to develop an efficient and reliable intraoperative, nonenzymatic method of isolating ADSCs for clinical use. This study aims to determine the (1) viability and proliferative capacity of ADSCs after exposure to vibrational energies and (2) efficacy of vibrational energy as a method of ADSC isolation from surgically harvested infrapatellar fat pad (IFP)...
January 2018: Plastic and Reconstructive Surgery. Global Open
Hamid Mousavi, Mohammad Mohammadi, Hossein Akbari Aghdam
Background: Injury to the infrapatellar branch of the saphenous nerve (IPBSN) is common after arthroscopic ACL reconstruction with hamstring tendon autograft, as reported in up to 88% of the cases. Due to close relationship between the IPBSN with pes anserine tendons insertion skin incision may sever IPBSN while harvesting gracillis and semitendinous tendons. As the IPBSN course at the anterior of knee is oblique, we hypothesized a parallel skin incision with nerve passage may decrease nerve injury...
January 2018: Archives of Bone and Joint Surgery
Radoslaw Grabowski, Alberto Gobbi, Sebastian Zabierek, Marcin E Domzalski
No abstract text is available yet for this article.
January 2018: Orthopaedic Journal of Sports Medicine
Guman Duan, Chang Liu, Weiwei Lin, Jiashen Shao, Kunpeng Fu, Yingzhen Niu, Fei Wang
BACKGROUND: A systematic review and meta-analysis was performed to investigate the risks associated with anterior knee pain (AKP) following primary total knee arthroplasty (TKA). METHODS: A computerized search was performed of the following databases: MEDLINE, Embase, and Cochrane Central (published prior to July 2017). A total of 37 studies, which included 1641 cases of AKP and 168,090 TKAs, were included in the meta-analysis. RESULTS: A subgroup analysis revealed that compared with those without the following medical conditions, patients who had an infrapatellar fat pad excision and more than 12 months of follow-up (odds ratio [OR] 12...
January 2, 2018: Journal of Arthroplasty
Chaofan Zhang, Teng Li, Kwong Yuen Chiu, Chunyi Wen, Aimin Xu, Chun Hoi Yan
AIM: To explore the role of an adipokine-termed fatty acid-binding protein 4 (FABP4) in osteoarthritis (OA). METHODS: Patients with primary knee OA and non-OA controls were included. Paired tissues including plasma, synovial fluid (SF), subcutaneous fat and infrapatellar fat pad (IPFP) were harvested during surgery. FABP4 concentration was determined by ELISA. RESULTS: Plasma FABP4 increased significantly with OA stage (n = 263). OA patients (n = 38) had significantly higher plasma and SF FABP4 than non-OA patients (n = 29)...
February 2018: Biomarkers in Medicine
Eva Steidle-Kloc, Torben Dannhauer, Wolfgang Wirth, Felix Eckstein
Obesity is a potent risk factor for knee osteoarthritis (OA) that is driven by mechanical and potentially endocrine mechanisms, and it affects women more frequently than men. The infrapatellar fat pat (IPFP) represents a potential link between obesity, intra-articular inflammation and structural pathology. Here we investigate whether the IPFP is responsive to body weight loss/gain in women and how its responsiveness to weight change compares to that of subcutaneous fat (SCF) of the thigh. All female participants of the Osteoarthritis Initiative (OAI) with ≥10% weight loss/gain between baseline and a 2-year follow-up were included...
February 1, 2018: Cells, Tissues, Organs
Yu Sun, Song Chen, Ming Pei
Growing evidence indicates that infrapatellar fat pad (IPFP)-derived stem cells (IPFSCs) exert robust proliferation capacities and multilineage differentiation potentials. However, few papers summarize the advantages that the IPFP and IPFSCs have in regenerative medicine. In this review we delineate the development and anatomy of the IPFP by comparing it with an adjacent fibrous tissue, synovium, and a more frequently harvested fat depot, subcutaneous adipose tissue. Furthermore, we explore the similarities and differences of stem cells from these three tissues in terms of IPFSCs, synovium-derived stem cells and subcutaneous adipose tissue-derived stem cells in proliferation capacity and tri-lineage differentiation potentials, including chondrogenesis, osteogenesis and adipogenesis...
January 24, 2018: Rheumatology
Cong Wang, Erman Chen, Chenyi Ye, Zhijun Pan
OBJECTIVE: This meta-analysis was performed to determine the efficacy of suprapatellar versus infrapatellar approach for tibia intramedullary nailing (IMN). METHODS: A systematic search was performed in PubMed, Embase, Cochrane library, CNKI and Wanfang. Cochrane collaboration's tool and the Newcastle-Ottawa scale were used to evaluate literature qualities. Meta-analysis was performed using RevMan 5.3 software. RESULTS: Eight studies were eligible, including two randomized controlled trials (RCTs) and six retrospective cohort trials...
January 30, 2018: International Journal of Surgery
Jihong Park, Matthew K Seeley, Devin Francom, C Shane Reese, J Ty Hopkins
In human motion studies, discrete points such as peak or average kinematic values are commonly selected to test hypotheses. The purpose of this study was to describe a functional data analysis and describe the advantages of using functional data analyses when compared with a traditional analysis of variance (ANOVA) approach. Nineteen healthy participants (age: 22 ± 2 yrs, body height: 1.7 ± 0.1 m, body mass: 73 ± 16 kg) walked under two different conditions: control and pain+effusion. Pain+effusion was induced by injection of sterile saline into the joint capsule and hypertonic saline into the infrapatellar fat pad...
December 2017: Journal of Human Kinetics
Anja J de Jong, Sabrina Pollastro, Joanneke C Kwekkeboom, Stefan N Andersen, Annemarie L Dorjée, Aleida M Bakker, Fawaz Alzaid, Antoine Soprani, Rob G H H Nelissen, Jan B Mullers, Nicolas Venteclef, Niek de Vries, Margreet Kloppenburg, René E M Toes, Andreea Ioan-Facsinay
Emerging evidence indicates that a dynamic interplay between the immune system and adipocytes contributes to the disturbed homeostasis in adipose tissue of obese subjects. Recently, we observed IL-6-secretion by CD4+ T cells from the stromal vascular fraction (SVF) of the infrapatellar fat pad (IFP) of knee osteoarthritis patients directly ex vivo. Here we show that human IL-6+ CD4+ T cells from SVF display a more activated phenotype than the IL-6- T cells, as evidenced by the expression of the activation marker CD69...
December 28, 2017: European Journal of Immunology
T Asaki, Kelun Wang, Y Luo, T Arendt-Nielsen, T Graven-Nielsen, L Arendt-Nielsen
Inflammation and the related acidity in peri-articular structures may be involved in pain generation and hyperalgesia in knee osteoarthritis. This study investigated pain and associated hyperalgesia provoked by infusion of acidic saline into the infrapatellar fat pad. Twenty-eight subjects participated in two sessions in which acidic saline (AS, pH 5) or neutral saline (NS, pH 7.4) were infused into the infrapatellar fat pad for 15 min. Pain intensity, pain area, mechanical and thermal sensitivity, and maximal voluntary knee extension force were recorded...
December 18, 2017: Experimental Brain Research. Experimentelle Hirnforschung. Expérimentation Cérébrale
Hannah Louise Paish, Nicolas Stewart Kalson, Graham Robert Smith, Alicia Del Carpio Pons, Thomas Edward Baldock, Nicholas Smith, Katarzyna Swist-Szulik, David John Weir, Michelle Bardgett, David John Deehan, Derek Austin Mann, Lee Anthony Borthwick
Fibroblasts persist within fibrotic scar tissue and exhibit considerable phenotypic and functional plasticity. Here, we hypothesized that scar-associated fibroblasts may be a source of stress-induced inflammatory exacerbations and pain. To test this idea we used a human model of surgery-induced fibrosis, total knee arthroplasty (TKA). Using a combination of tissue protein expression profiling and bioinformatics we discovered that many months following TKA the fibrotic joint exists in a state of unresolved chronic inflammation...
December 14, 2017: American Journal of Pathology
Ken Ye, Kathy Traianedes, Shalley A Robins, Peter F M Choong, Damian E Myers
The aim of this pilot project was to introduce a novel use of acellular dermal matrix (ADM) in combination with infrapatellar fat pad mesenchymal stromal cells (IPFP-MSCs) to effect repair in a rabbit osteochondral defect model. ADM, in a range of surgical procedures, has been shown to promote remodelling of tissue at the site of implantation. Rabbit-derived ADM (rabADM) was prepared from the skin of donor rabbits. Autologous IPFP-MSCs were obtained at the time of knee surgery. Osteochondral defects (4mm cartilage outer/2mm central bone defect) were drilled into distal femoral condyles of 12 New Zealand White rabbits...
December 15, 2017: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
Urszula Skalska, Ewa Kuca-Warnawin, Anna Kornatka, Iwona Janicka, Urszula Musiałowicz, Tomasz Burakowski, Ewa Kontny
Adipose-derived mesenchymal stem cells (ASCs) have immunoregulatory properties, but their activity is dependent on signals provided by the local microenvironment. It is likely that highly inflammatory milieu of rheumatoid joint affects ASCs activity. To test this hypothesis, the function of rheumatoid ASCs derived from articular adipose tissue (AT-ASCs) and ASCs derived from subcutaneous adipose tissue (Sc-ASCs) has been analysed. Articular adipose tissue (infrapatellar fat pad) and subcutaneous adipose tissue (from the site of skin closure with sutures) were obtained from rheumatoid arthritis (RA) patients undergoing total knee joint replacement surgery...
December 2017: Autoimmunity
Antoine Moraux, Stefano Bianchi, Thomas Le Corroller
We report on the imaging features of 6 soft tissue masses in the anterolateral aspect of the knee related to a focal defect of the lateral patellar retinaculum. In 4 patients (3 female and 1 male; 6-65 years) presenting with nontender palpable soft tissue masses in the anterolateral aspect of their knees, ultrasonography showed a focal defect of the lateral patellar retinaculum with herniation of the Hoffa fat pad, which was only visible in flexion. A magnetic resonance imaging examination performed in 1 case confirmed the defect in the lateral patellar retinaculum but did not show a mass, as the knee was examined only at 10° of flexion...
December 4, 2017: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
B Wang, W Liu, D Xing, R Li, C Lv, Y Li, X Yan, Y Ke, Y Xu, Y Du, J Lin
Subchondral bone has been identified as an attractive target for KOA. To determine whether a minimally invasive micro-scaffolds could be used to induce regeneration of knee subchondral bone lesions, and to examine the protective effect of subchondral bone regeneration on upper cartilage, a ready-to-use injectable treatment with nanohydroxyapatite-chitosan-gelatin micro-scaffolds (HaCGMs) is proposed. Human-infrapatellar-fat-pad-derived adipose stem cells (IPFP-ASCs) were used as a cellular model to examine the osteo-inductivity and biocompatibility of HaCGMs, which were feasibly obtained with potency for multi-potential differentiations...
December 1, 2017: Scientific Reports
Susan E Critchley, Rajalakshmanan Eswaramoorthy, Daniel J Kelly
There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or diseased joints, their dedifferentiation during in vitro expansion, and a diminished capacity to synthesise cartilage-specific extracellular matrix components with age and disease. This has motivated the use of adult stem cells with either freshly isolated or culture-expanded chondrocytes for cartilage repair applications; however, the ideal combination of cells and environmental conditions for promoting robust chondrogenesis remains unclear...
November 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
Joerg Franke, Annika Homeier, Lars Metz, Thilo Wedel, Volker Alt, Sven Spät, Bernd Hohendorff, Reinhard Schnettler
BACKGROUND: During intramedullary nailing of tibial fractures, the insertion angle of the nail is of great importance. When the nail impacts the posterior cortex due to a large insertion angle with a dorsal target course, higher insertion forces are needed, and the danger of iatrogenic fractures increases. Accordingly, the insertion direction should be as parallel as possible to the longitudinal axis of the tibia. We aimed to confirm the hypothesis that intramedullary nailing of tibial fractures can be performed with smaller insertion angles via a suprapatellar approach rather than infrapatellar approach...
November 20, 2017: European Journal of Trauma and Emergency Surgery: Official Publication of the European Trauma Society
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