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https://www.readbyqxmd.com/read/29141683/pellet-coculture-of-osteoarthritic-chondrocytes-and-infrapatellar-fat-pad-derived-mesenchymal-stem-cells-with-chitosan-hyaluronic-acid-nanoparticles-promotes-chondrogenic-differentiation
#1
Shu Huang, Xiongbo Song, Tao Li, Jingfang Xiao, Yemiao Chen, Xiaoyuan Gong, Weinan Zeng, Liu Yang, Cheng Chen
BACKGROUND: Cell source plays a key role in cell-based cartilage repair and regeneration. Recent efforts in cell coculture have attempted to combine the advantages and negate the drawbacks of the constituent cell types. The aim of this study was to evaluate the chondrogenic outcome of articular chondrocytes (ACs) and infrapatellar fat pad (IPFP)-derived mesenchymal stem cells (MSCs) in direct coculture. METHODS: ACs and IPFP MSCs from the same patients with knee osteoarthritis (OA) were cocultured in monolayer and in pellets...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29127754/-osteoarthritis-as-part-of-metabolic-syndrome
#2
Karel Pavelka
Osteoarthritis (OA) is the most frequent joint disease, whereas etiopathogenesis of OA is not entirely clarified. It is a heterogeneous disorder and genetic as well as biomechanical, endocrine and inflammatory effects may be involved in its origin. The author examines the problems concerning relationships between the metabolic syndrome and OA, and states that the prevalence of metabolic syndrome in patients with OA is higher than in those without OA (59 % vs 23 %). It remains problematic that one of the main components of metabolic syndrome is obesity which in itself is a risk factor for arthrosis development in the weight-bearing joints, not for OA in the hands...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/29105354/low-oxygen-conditions-promote-synergistic-increases-in-chondrogenesis-during-co-culture-of-human-osteoarthritic-stem-cells-and-chondrocytes
#3
Susan E Critchley, Rajalakshmanan Eswaramoorthy, Daniel J Kelly
There has been increased interest in co-cultures of stem cells and chondrocytes for cartilage tissue engineering as there are the limitations associated with using either cell type alone. Drawbacks associated with the use of chondrocytes include the limited numbers of cells available for isolation from damaged or diseased joints, their dedifferentiation during in vitro expansion and a diminished capacity to synthesise cartilage-specific extracellular matrix components with age and disease. This has motivated the use of adult stem cells with either freshly isolated or culture expanded chondrocytes for cartilage repair applications, however the ideal combination of cells and environmental conditions for promoting robust chondrogenesis remains unclear...
November 3, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29045182/validity-of-radiograph-based-infrapatellar-fat-pad-opacity-grading-for-assessing-knee-synovitis-correlation-with-contrast-enhanced-mri
#4
Seong Jong Yun, Youngsik Lim, Wook Jin, Yong Sung Park, Sun Hwa Lee, Kyung Nam Ryu
OBJECTIVE: The purpose of this study was to determine the validity of infrapatellar fat pad (IPFP) opacity grading based on lateral knee radiography for assessing knee synovitis using correlation with contrast-enhanced (CE) MRI. MATERIALS AND METHODS: Retrospective reviews of radiographs and CE knee MR images from 79 patients were independently performed by two radiologists. They evaluated IPFP opacity alteration (IPFPCR) and joint effusion (EFFCR) grades on lateral knee conventional radiographs, IPFP signal intensity alteration (IPFPMR) and joint effusion (EFFMR) grades on CE MR images, and synovitis (SYNMR) grade in nine divided regions, three compartments (parapatellar, periligamentous, perimeniscal), and the whole knee on CE MR images...
October 18, 2017: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29018484/infrapatellar-fat-pad-stem-cells-from-developmental-biology-to-cell-therapy
#5
REVIEW
Ronaldo J F C do Amaral, Henrique V Almeida, Daniel J Kelly, Fergal J O'Brien, Cathal J Kearney
The ideal cell type to be used for cartilage therapy should possess a proven chondrogenic capacity, not cause donor-site morbidity, and should be readily expandable in culture without losing their phenotype. There are several cell sources being investigated to promote cartilage regeneration: mature articular chondrocytes, chondrocyte progenitors, and various stem cells. Most recently, stem cells isolated from joint tissue, such as chondrogenic stem/progenitors from cartilage itself, synovial fluid, synovial membrane, and infrapatellar fat pad (IFP) have gained great attention due to their increased chondrogenic capacity over the bone marrow and subcutaneous adipose-derived stem cells...
2017: Stem Cells International
https://www.readbyqxmd.com/read/28993563/mri-findings-consistent-with-peripatellar-fat-pad-impingement-how-much-related-to-patellofemoral-maltracking
#6
Mohamed Jarraya, Luis E Diaz, Frank W Roemer, William F Arndt, Ajay R Goud, Ali Guermazi
Peripatellar fat pads are intracapsular extrasynovial adipose cushions that accommodate the changing shape and volume of articular spaces during movement. Variations in bone geometry, passive and active stabilization mechanisms and/or functional demands may lead to peripatellar fat pad abnormalities. While peripatellar fat pads may be affected a variety of conditions such as synovial inflammation, tumor and fibrosis, a mechanical origin should also be considered. Commonly, the clinical term "impingement" is used synonymously in the radiological literature to refer to three distinct entities of structural peripatellar fat pad abnormalities: superolateral the infrapatellar fat pad (Hoffa fat pad) edema, suprapatellar fat pad edema, and prepatellar fat pad edema, implying a mechanical origin of these conditions...
October 10, 2017: Magnetic Resonance in Medical Sciences: MRMS
https://www.readbyqxmd.com/read/28990676/arthroscopic-approach-and-anatomy-of-the-stifle-joint-in-the-rabbit
#7
Sarah Torrey Peters, Markus Wilke, Tanja Schmid
OBJECTIVE: To describe a technique and normal findings for arthroscopy of the stifle in rabbits. STUDY DESIGN: Cadaver study. ANIMALS: Twenty cadaveric stifles from New Zealand White rabbits were examined. METHODS: The arthroscope was placed through a medial portal, and instrument portals were created on the lateral aspect of the joint. The same portals were used for examination of the entire joint and palpation of structures with a probe...
October 9, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/28957567/infrapatellar-fat-pad-features-in-osteoarthritis-a-histopathological-and-molecular-study
#8
Marta Favero, Hamza El-Hadi, Elisa Belluzzi, Marnie Granzotto, Andrea Porzionato, Gloria Sarasin, Anna Rambaldo, Claudio Iacobellis, Augusto Cigolotti, Chiara Giulia Fontanella, Arturo Natali, Roberta Ramonda, Pietro Ruggieri, Raffaele De Caro, Roberto Vettor, Marco Rossato, Veronica Macchi
Objective: The infrapatellar fat pad (IFP) is considered a local producer of adipocytokines, suggesting a potential role in OA. The objective of this study was to evaluate the histopathological and molecular characteristics of OA IFPs compared with controls. Methods: The histopathological characteristics of IFPs were evaluated in patients undergoing total knee replacements and in control patients (without OA), considering the following parameters: presence of inflammatory cells, vascularization, adipose lobules dimension and thickness of the interlobular septa...
October 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/28906305/risk-of-knee-sepsis-following-treatment-of-open-tibia-fractures-a-multicenter-comparison-of-suprapatellar-and-infrapatellar-approaches
#9
Geoffrey S Marecek, Luke T Nicholson, Frances H Broghammer, Michael Talerico, Caroline Tougas, Derek J Donegan, John A Scolaro
OBJECTIVES: The suprapatellar approach for medullary nailing of the tibia is increasing. This requires intra-articular passage of instruments, which theoretically places the knee at risk for postoperative sepsis in the setting of open fracture. We hypothesized that the risk of knee sepsis is similar after suprapatellar or infrapatellar nailing of open tibia fractures. DESIGN: Retrospective, multicenter. SETTING: Three urban Level-1 trauma centers PATIENTS:: All patients treated with medullary nailing for open diaphyseal tibia fractures (OTA 42) from 2009 to 2015...
September 11, 2017: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/28888527/complications-following-harvesting-of-patellar-tendon-or-hamstring-tendon-grafts-for-anterior-cruciate-ligament-reconstruction-systematic-review-of-literature
#10
REVIEW
A Hardy, L Casabianca, K Andrieu, L Baverel, T Noailles
Anterior cruciate ligament (ACL) reconstruction can be performed with an autograft, which is most often harvested from the patient's hamstring tendon (HT) or patellar tendon (PT). However, autograft harvesting leads to morbidity that is by no means insignificant. A systematic review of literature was performed to define the incidence of complications related to graft harvesting and the methods to prevent these complications. In March 2017, a systemic review of literature was performed using the keywords"harvesting", "harvest", "morbidity", "complication", "cruciate ligament"...
September 6, 2017: Orthopaedics & Traumatology, Surgery & Research: OTSR
https://www.readbyqxmd.com/read/28888201/tgf-%C3%AE-1-presenting-enzymatically-cross-linked-injectable-hydrogels-for-improved-chondrogenesis
#11
Aditya Arora, Aman Mahajan, Dhirendra S Katti
In this work, we developed a novel enzymatically cross-linked injectable hydrogel composed of carboxymethyl cellulose (CMC), sulfated carboxymethyl cellulose (sCMC) and gelatin for delivery of infrapatellar fat pad derived MSCs and articular chondrocytes to a cartilage defect site while enabling TGF-β1 mediated chondrogenesis. The sCMC component in the hydrogel served the purpose of mimicking heparan sulfate and thus enabled strong binding with TGF-β1 and its consequential long term presentation to the encapsulated cells...
August 24, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28859260/reply-to-the-letter-to-editor-by-macchi-et-al
#12
Natalia S Harasymowicz, Nick D Clement, Asim Azfer, Richard Burnett, Donald M Salter, Hamish Simpson
We thank Macchi et al. for their comments regarding our study describing regional differences between perisynovial and infrapatellar adipose tissue (AT) depots in patients with end stage osteoarthritis (OA) of the knee [1]. They summarize our findings concisely and contextualize this data with their own findings. The main goal of our paper was to quantify the differences between synovial and infrapatellar fat pad (IPFP) AT deposits from the same patient. The synovial AT had more pro-inflammatory/pro-fibrotic response than the IPFP in patients with obesity...
August 31, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28855693/rheumatoid-arthritis-characterization-of-the-infrapatellar-fat-pad
#13
Liesbet Lieben
No abstract text is available yet for this article.
October 2017: Nature Reviews. Rheumatology
https://www.readbyqxmd.com/read/28841726/incidence-and-characterization-of-hypoesthesia-in-the-distribution-of-the-infrapatellar-branch-of-the-saphenous-nerve-after-anterior-cruciate-ligament-reconstruction-a-prospective-study-of-patient-reported-numbness
#14
Steven Brad Cohen, Russell Flato, Jocelyn Wascher, Ryan Watson, Matthew Salminen, Daniel O'Brien, Fotios Tjoumakaris, Michael Ciccotti
No abstract text is available yet for this article.
August 25, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/28831763/relationship-between-magnetic-resonance-imaging-findings-radiological-grading-psychological-distress-and-pain-in-patients-with-symptomatic-knee-osteoarthritis
#15
Marina Carotti, Fausto Salaffi, Marco Di Carlo, Andrea Giovagnoni
BACKGROUND: Synovial hypertrophy, synovial effusions, and abnormalities in the subchondral bone play a key role in the pathogenesis of osteoarthritis (OA) and are associated with pain. Understanding and careful clinical assessment together with better imaging such as magnetic resonance imaging (MRI) of the knee may improve treatment strategies. The aim of this cross-sectional study was to investigate the associations between the structural findings on MRI (bone marrow lesions [BMLs], synovitis, cartilage defects, meniscal lesions), X-ray examination (Kellgren and Lawrence [K/L] grade), and psychological aspects with pain in patients with knee osteoarthritis (KOA)...
August 22, 2017: La Radiologia Medica
https://www.readbyqxmd.com/read/28816507/arthroscopic-harvest-of-adipose-derived-mesenchymal-stem-cells-from-the-infrapatellar-fat-pad
#16
Jason L Dragoo, Wenteh Chang
BACKGROUND: The successful isolation of adipose-derived mesenchymal stem cells (ADSCs) from the arthroscopically harvested infrapatellar fat pad (IFP) would provide orthopaedic surgeons with an autologous solution for regenerative procedures. PURPOSE: To demonstrate the quantity and viability of the mesenchymal stem cell population arthroscopically harvested from the IFP as well as the surrounding synovium. STUDY DESIGN: Descriptive laboratory study...
November 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28800775/lack-of-high-bmi-related-features-in-adipocytes-and-inflammatory-cells-in-the-infrapatellar-fat-pad-ifp
#17
Anja J de Jong, Inge R Klein-Wieringa, Stefan N Andersen, Joanneke C Kwekkeboom, Linda Herb-van Toorn, Badelog J E de Lange-Brokaar, Danny van Delft, John Garcia, Wu Wei, Huub J L van der Heide, Yvonne M Bastiaansen-Jenniskens, Gerjo J V M van Osch, Annemarie M Zuurmond, Vedrana Stojanovic-Susulic, Rob G H H Nelissen, René E M Toes, Margreet Kloppenburg, Andreea Ioan-Facsinay
BACKGROUND: Obesity is associated with the development and progression of osteoarthritis (OA). Although the infrapatellar fat pad (IFP) could be involved in this association, due to its intracapsular localization in the knee joint, there is currently little known about the effect of obesity on the IFP. Therefore, we investigated cellular and molecular body mass index (BMI)-related features in the IFP of OA patients. METHODS: Patients with knee OA (N = 155, 68% women, mean age 65 years, mean (SD) BMI 29...
August 11, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/28790478/entrapment-neuropathy-of-the-infrapatellar-branch-of-the-saphenous-nerve-treated-by-partial-division-of-sartorius
#18
Gururaj Hosahalli, Adam Sierakowski, Hari Venkatramani, S Raja Sabapathy
We describe a case of entrapment neuropathy of the infrapatellar branch of the saphenous nerve as it pierces sartorius muscle. This is a rare cause of anteromedial knee pain that is easily overlooked and may be mistaken as arising from other anatomical structures in that region. The pain was successfully treated by partially dividing the sartorius muscle and translocating the nerve away from the site of entrapment. It is important to consider entrapment neuropathy of the infrapatellar branch of the saphenous nerve as a differential diagnosis when assessing a patient with anteromedial knee pain...
July 2017: Indian Journal of Orthopaedics
https://www.readbyqxmd.com/read/28770522/hoffa-s-fat-pad-abnormality-in-the-development-of-knee-osteoarthritis
#19
Wojciech Paduszyński, Mateusz Jeśkiewicz, Paweł Uchański, Sebastian Gackowski, Marek Radkowski, Urszula Demkow
Over the past two decades, many hypotheses have been put forward to explain the cause of knee osteoarthritis. Scientific reports bring up the role of adipose tissue in the activation of the inflammatory mechanisms, which is a characteristic feature of osteoarthritis natural history. Adipose tissue produces and releases cytokines, interleukins, and growth factors by means of paracrine, endocrine, and autocrine mechanisms. Hoffa's fat pad (infrapatellar adipose tissue) plays a viable role in the initiation and progression of osteoarthritis due to its role in the activation and release of pro-inflammatory mediators...
August 3, 2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28769981/human-suprapatellar-fat-pad-derived-mesenchymal-stem-cells-induce-chondrogenesis-and-cartilage-repair-in-a-model-of-severe-osteoarthritis
#20
Ignacio Muñoz-Criado, Jose Meseguer-Ripolles, Maravillas Mellado-López, Ana Alastrue-Agudo, Richard J Griffeth, Jerónimo Forteza-Vila, Ramón Cugat, Montserrat García, Victoria Moreno-Manzano
Cartilage degeneration is associated with degenerative bone and joint processes in severe osteoarthritis (OA). Spontaneous cartilage regeneration is extremely limited. Often the treatment consists of a partial or complete joint implant. Adipose-derived stem cell (ASC) transplantation has been shown to restore degenerated cartilage; however, regenerative differences of ASC would depend on the source of adipose tissue. The infra- and suprapatellar fat pads surrounding the knee offer a potential autologous source of ASC for patients after complete joint substitution...
2017: Stem Cells International
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