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https://www.readbyqxmd.com/read/27925193/systemic-and-local-adipose-tissue-in-knee-osteoarthritis
#1
REVIEW
Elisa Belluzzi, Hamza El Hadi, Marnie Granzotto, Marco Rossato, Roberta Ramonda, Veronica Macchi, Raffaele De Caro, Roberto Vettor, Marta Favero
Osteoarthritis is a common chronic joint disorder affecting older people. The knee is the major joint affected. The symptoms of osteoarthritis include limited range of motion, joint swelling, and pain causing disability. There are no disease modifying drugs available, and treatments are mainly focused on pain management. Total knee replacement performed at the end stage of the disease is considered the only cure available. It has been found that obese people have an increased risk to develop not only knee but also hand osteoarthritis...
December 7, 2016: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/27922951/anatomic-and-ultrasonographic-evaluation-of-the-knee-sensory-innervation-a-cadaveric-study-to-determine-anatomic-targets-in-the-treatment-of-chronic-knee-pain
#2
Jorge M Orduña Valls, Ricardo Vallejo, Pablo López Pais, Eliezer Soto, Daniel Torres Rodríguez, David L Cedeño, Carlos Tornero Tornero, Maximino Quintáns Rodríguez, Aurora Baluja González, Julián Álvarez Escudero
BACKGROUND AND OBJECTIVES: Osteoarthrosis is a main cause of knee pain in the elderly. Pain associated with this condition is often refractory to conservative treatment. Total knee replacement may be the best option for severe pathologies; however, the occurrence of a chronic pain state after knee replacement has been well documented in the literature. The previous descriptions of the genicular nerves have been considered somewhat inaccurate. This innervation is complex and exhibits significant interindividual variability...
December 5, 2016: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/27916577/association-of-fibrosis-in-the-infrapatellar-fat-pad-and-degenerative-cartilage-change-of-patellofemoral-joint-after-anterior-cruciate-ligament-reconstruction
#3
Kyoung Ho Yoon, Dae Hyun Tak, Taeg Su Ko, Sang Eon Park, Juhyun Nam, Sang Hak Lee
BACKGROUND: The purpose of this study was to evaluate the prevalence and risk factor of cartilage degeneration of the patellofemoral joint (PFJ) that was diagnosed by second-look arthroscopy. METHODS: One-hundred and seven patients who underwent ACL reconstruction were evaluated by preoperative MRI, postoperative MRI and second-look arthroscopy. Severity of infrapatellar fat pad (IPFP) fibrosis was evaluated by MRI at an average of 26months after ACL reconstruction...
December 1, 2016: Knee
https://www.readbyqxmd.com/read/27909679/arthroscopic-treatment-of-patellar-tendinopathy-use-of-70%C3%A2-arthroscope-and-superolateral-portal
#4
Orestis Karargyris, Vipul Mandalia
Surgical treatment of recalcitrant patellar tendinopathy includes both the open surgical approach and minimally invasive arthroscopic debridement. A variety of arthroscopic techniques have been described that involve the use of a standard 30° arthroscope and standard anterolateral and anteromedial portals. As a result, visualization of the infrapatellar region can be variable, and it may be necessary to create additional portals. A 70° arthroscope provides the advantage of a wider field of view to the surgeon...
October 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/27908299/the-infrapatellar-fat-pad-induces-inflammatory-and-degradative-effects-in-articular-cells-but-not-through-leptin-or-adiponectin
#5
Jean-Baptiste Gross, Cecile Guillaume, Pascale Gegout-Pottie, Pascal Reboul, Jean-Yves Jouzeau, Didier Mainard, Nathalie Presle
OBJECTIVES: Based on a novel approach suggesting a role of adipose tissue in osteoarthritis (OA), we aimed to determine whether the infrapatellar fat pad (IFP) may affect joint cell functions through adipokines. METHODS: The conditioned media of IFP and subcutaneous adipose tissue from OA patients were used to determine the production of leptin and adiponectin, and to stimulate chondrocytes and fibroblast-like synoviocytes (FLS). Blocking experiments were carried out to evaluate the contribution of adipokines to IFP effects...
November 13, 2016: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/27900340/retropatellar-accessory-portals-for-improved-access-to-the-patella-anatomic-description-and-evaluation-of-safety
#6
Jason L Koh, Anthony L Logli
BACKGROUND: Standard knee arthroscopy portals are frequently used to address retropatellar chondral pathology. Alternative portals may offer a safe and simple substitute, particularly when reaching the base of deep lesions is required. PURPOSE: To describe and assess the safety of accessory retropatellar portals. STUDY DESIGN: Descriptive laboratory study. METHODS: An anatomic study was performed on 10 fresh-frozen cadaveric knees...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27878340/anatomical-risk-evaluation-of-iatrogenic-injury-to-the-infrapatellar-branch-of-the-saphenous-nerve-during-medial-meniscus-arthroscopic-surgery
#7
Guillaume Koch, Agathe Kling, Nitin Ramamurthy, Faramarz Edalat, Roberto Luigi Cazzato, Jean-Luc Kahn, Julien Garnon, Philippe Clavert
PURPOSE: To determine the relationship of the medial meniscus with the infrapatellar branches of the saphenous nerve, the primary goal is to define and characterize different risk areas for these nerves during medial meniscus surgery. METHODS: After dissecting 20 embalmed cadaver knees, we defined 7 readily identifiable anatomical landmarks. For each knee, we recorded 2 morphological criteria and 16 measurements. RESULTS: The most common anatomical course is a main trunk that is 8 mm anterior to the tuberculum adductorium and 60 mm posterior to the midpoint of the medial patellar margin...
November 22, 2016: Surgical and Radiologic Anatomy: SRA
https://www.readbyqxmd.com/read/27853846/location-and-gene-specific-effects-of-methylprednisolone-acetate-on-mitigating-il1%C3%AE-induced-inflammation-in-mature-ovine-explant-knee-tissue
#8
Kristen I Barton, Bryan J Heard, May Chung, Johnathan L Sevick, C Ryan Martin, Yamini Achari, Cyril B Frank, Nigel G Shrive, David A Hart
OBJECTIVE AND DESIGN: To determine the ability of methylprednisolone acetate (MPA) to influence interleukin 1β (IL1β)-induced gene expression in ovine knee joint tissues. MATERIAL OR SUBJECTS: Ovine articular cartilage, synovium, and infrapatellar fat pad (IPFP) explants. TREATMENT: Explants were treated with 10(-3) M or 10(-4) M MPA. METHODS: Explant treatment groups: (1) control (DMEM); (2) inflammation (IL1β); (3) IL1β + 10(-3) M MPA; or (4) IL1β + 10(-4) M MPA...
November 16, 2016: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/27846646/the-variable-emergence-of-the-infrapatellar-branch-of-the-saphenous-nerve
#9
Brandon Michael Henry, Krzysztof A Tomaszewski, Przemysław A Pękala, Piravin Kumar Ramakrishnan, Dominik Taterra, Karolina Saganiak, Ewa Mizia, Jerzy A Walocha
The infrapatellar branch of the saphenous nerve (IPBSN) is a cutaneous nerve of the lower limb, which arises distal to the adductor canal. High variability in the emergence, course, branching, termination, and morphometrics of the IPBSN poses an increased risk of injury to the nerve during surgical interventions on the anteromedial aspect of the knee. The aim of this study was to describe the anatomical characteristics of the IPBSN. This study utilized cadaveric (n = 100) and ultrasonography (n = 30) assessments, and meta-analysis...
November 15, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27830881/transtendinous-course-of-the-infrapatellar-branch-of-saphenous-nerve-a-contribution-to-the-etiology-of-entrapment-neuropathy-and-modification-of-the-existing-classification
#10
Konstantinos Natsis, Georgios Konstantinidis, Georgios Geropoulos, Trifon Totlis, Nikolaos Lazaridis, Thomas Tegos
BACKGROUND: The course of the infrapatellar branch of saphenous nerve (IPBSN) in relation to the Sartorius muscle has been classified into presartorial, transsartorial and retrosartorial types. Mechanical compression of the IPBSN within the sartorius tendon has been surgically recognized as a cause of entrapment neuropathy. Purpose of the present study was to differentiate the IPBSNs penetrating the sartorius tendon from those penetrating the sartorius muscle, from an anatomical and clinical point of views and thus modifying the existing classification...
November 10, 2016: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/27781068/chondrogenic-potency-analyses-of-donor-matched-chondrocytes-and-mesenchymal-stem-cells-derived-from-bone-marrow-infrapatellar-fat-pad-and-subcutaneous-fat
#11
John Garcia, Claire Mennan, Helen S McCarthy, Sally Roberts, James B Richardson, Karina T Wright
Autologous chondrocyte implantation (ACI) is a cell-based therapy that has been used clinically for over 20 years to treat cartilage injuries more efficiently in order to negate or delay the need for joint replacement surgery. In this time, very little has changed in the ACI procedure, but now many centres are considering or using alternative cell sources for cartilage repair, in particular mesenchymal stem cells (MSCs). In this study, we have tested the chondrogenic potential of donor-matched MSCs derived from bone marrow (BM), infrapatellar fat pad (FP), and subcutaneous fat (SCF), compared to chondrocytes...
2016: Stem Cells International
https://www.readbyqxmd.com/read/27768625/current-evidence-plate-versus-intramedullary-nail-for-fixation-of-distal-tibia-fractures-in-2016
#12
Heather A Vallier
Displaced distal tibia shaft fractures are effectively treated with standard plates and intramedullary nails. Plate fixation performed with meticulous soft tissue handling results in minimal risks of infection and poor wound healing. Standard plates have high rates of primary union, whereas locking plates may delay union because of increased stiffness. Tibial healing may also be delayed after plating of the fibula, although fibula reduction and fixation may aid accuracy of reduction of the tibia. Malalignment occurs more often with infrapatellar intramedullary nailing versus plates, and early results of suprapatellar nailing appear promising in minimizing intraoperative malalignment...
November 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27765415/-infrapatellar-hypertrichosis-in-adult-dermatomyositis
#13
F-Z Elfatoifi, S Chiheb, P Humbert
No abstract text is available yet for this article.
October 17, 2016: Annales de Dermatologie et de Vénéréologie
https://www.readbyqxmd.com/read/27763961/no-incidence-of-postoperative-knee-sepsis-with-suprapatellar-nailing-of-open-tibia-fractures
#14
Phillip M Mitchell, Benjamin M Weisenthal, Cory A Collinge
OBJECTIVE: To evaluate the incidence of knee sepsis following suprapatellar nailing of open tibia fractures. DESIGN: Retrospective SETTING:: ACS Level 1 trauma centerPatients/Participants: We reviewed 139 open tibia fractures that underwent suprapatellar nailing as definitive treatment over a five-year period (January 1, 2011 to January 1, 2016). The majority of patients (90%, n=126) underwent intramedullary nailing at the time of their initial surgery. We defined knee sepsis as intra-articular infection requiring operative debridement, either open or arthroscopically, within one month's time...
October 1, 2016: Journal of Orthopaedic Trauma
https://www.readbyqxmd.com/read/27729069/hypointense-signals-in-the-infrapatellar-fat-pad-assessed-by-magnetic-resonance-imaging-are-associated-with-knee-symptoms-and-structure-in-older-adults-a-cohort-study
#15
Weiyu Han, Dawn Aitken, Zhaohua Zhu, Andrew Halliday, Xia Wang, Benny Antony, Flavia Cicuttini, Graeme Jones, Changhai Ding
BACKGROUND: There are few clinical and epidemiological studies reporting the association between abnormal changes within the IPFP and knee osteoarthritic changes. This study aims to describe the associations between hypointense signals in the infrapatellar fat pad (IPFP) and knee structural change and symptoms in older adults. METHODS: Participants (n = 874) were selected randomly from local community and followed up 2.7 years later (range 2.6-3.3 years). T1- or T2-weighted fat-suppressed magnetic resonance imaging (MRI) was assessed for IPFP hypointense signal, cartilage volume, cartilage defects, and bone marrow lesions (BMLs)...
October 12, 2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27726455/co-culture-with-infrapatellar-fat-pad-differentially-stimulates-proteoglycan-synthesis-and-accumulation-in-cartilage-and-meniscus-tissues
#16
James F Nishimuta, Monica F Bendernagel, Marc E Levenston
PURPOSE: Although osteoarthritis is widely viewed as a disease of the whole joint, relatively few studies have focused on interactions among joint tissues in joint homeostasis and degeneration. In particular, few studies have examined the effects of the infrapatellar fat pad (IFP) on cartilaginous tissues. The aim of this study was to test the hypothesis that co-culture with healthy IFP would induce degradation of cartilage and meniscus tissues. MATERIALS AND METHODS: Bovine articular cartilage, meniscus, and IFP were cultured isolated or as cartilage-fat or meniscus-fat co-cultures for up to 14 days...
October 11, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27706208/influence-of-the-infrapatellar-fat-pad-resection-during-total-knee-arthroplasty-a-systematic-review-and-meta-analysis
#17
Chenyi Ye, Wei Zhang, Weigang Wu, Mingyuan Xu, Nwofor Samuel Nonso, Rongxin He
BACKGROUND: To enhance surgical exposure, resection of the infrapatellar fat pad (IPFP) is usually a routine procedure in total knee arthroplasty (TKA). However, there is conflicting evidence regarding whether IPFP resection during TKA impairs clinical outcome. We performed a systematic review and meta-analysis to clarify the influence of IPFP resection on primary TKA. METHODS: Embase, PubMed, and the Cochrane Library were systematically searched up to August 2016 to identify relevant studies...
2016: PloS One
https://www.readbyqxmd.com/read/27685767/infrapatellar-fat-pad-excision-during-total-knee-arthroplasty-did-not-alter-the-patellar-tendon-length-a-5-year-follow-up-study
#18
Yunus İmren, Süleyman Semih Dedeoğlu, Murat Çakar, Haluk Çabuk, Tahsin Olgun Bayraktar, Hakan Gürbüz
Partial or total resection of the infrapatellar fat pad (IPFP) helps surgeon improve access to lateral tibial plateau for better placement of the knee prosthesis. We aimed to investigate the effect of IPFP excision on clinical and radiologic outcomes including patellar tendon length (PTL), range of motion, and functional scores after total knee arthroplasty (TKA) at 5-year follow-up. We retrospectively evaluated postoperative first X-rays (day 0) and postoperative final 5-year control views of 228 knees in patients with primary osteoarthritis who underwent TKA between September 2006 and December 2009 in our hospital...
September 29, 2016: Journal of Knee Surgery
https://www.readbyqxmd.com/read/27666183/assessment-of-anterior-subcutaneous-hypersignal-on-proton-density-weighted-mr-imaging-of-the-knee-and-relationship-with-anterior-knee-pain
#19
E N Unlu, Y Turhan, D M Kos, A A Safak
PURPOSE: The purpose of this study was to evaluate the prevalence of anterior subcutaneous hypersignal indicating edema on proton-density (PD)-weighted MRI of the knee and to determine whether reporting anterior edema is clinically relevant. MATERIALS AND METHODS: One hundred and ninety-one knee MRIs from 162 patients were reviewed for anterior subcutaneous edema. There were 92 men and 70 women with a mean age of 41.72years±13.92 (SD) (range, 15-80years) years and a mean body weight of 75...
September 22, 2016: Diagnostic and Interventional Imaging
https://www.readbyqxmd.com/read/27634419/the-interaction-between-ngf-induced-hyperalgesia-and-acid-provoked-pain-in-the-infrapatellar-fat-pad-and-tibialis-anterior-muscle-of-healthy-volunteers
#20
T K Munkholm, L Arendt-Nielsen
BACKGROUND: Tissue pH is lowered in inflamed tissues, and the increased proton concentration activates acid-sensing ion channels (ASICs), contributing to pain and hyperalgesia. ASICs can be upregulated by nerve growth factor (NGF). The aim of this study was to investigate two new human experimental pain models combining NGF- and acid-induced pain in a randomized, controlled, double-blind study. METHODS: In experiment 1, volunteers (N = 16) received an injection of either NGF or isotonic saline in each infrapatellar fat pad (IFP)...
September 15, 2016: European Journal of Pain: EJP
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