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https://www.readbyqxmd.com/read/29790099/the-changes-underwent-by-free-fat-pads-used-for-pulmonary-air-leakage-repair
#1
Isao Matsumoto, Makoto Oda, Hiroko Ikeda, Keiichi Kimura, Masaya Tamura, Hirofumi Takemura
The use of free fat pads is effective for repairing pulmonary air leakage clinically. It has been reported that the free pericardial fat pad (FPFP) used to repair the lung remained at the transplanted site in many cases according to images. However, no information is available regarding what type of actual changes these free fat pads with no blood supply undergo. We examined changes in an FPFP that was used to repair pulmonary air leakage in a patient who underwent a surgery for lung cancer 1 year ago. Although the FPFP transplanted to the pleural defect remained without deforming morphologically in this patient 1 year after the first surgery, pathological findings suggested fat necrosis surrounded by fibrous tissue...
May 22, 2018: General Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/29789266/microvascular-volume-in-symptomatic-achilles-tendons-is-associated-with-visa-a-score
#2
S F E Praet, J H Ong, C Purdam, M Welvaert, G Lovell, L Dixon, J E Gaida, J Anglim, S Manzanero, N Vlahovich, D Hughes, G Waddington
OBJECTIVES: The role of neovascularisation in tendinopathy is still poorly understood, potentially due to technical limitations of conventional power Doppler ultrasound. This study aimed to investigate the association between contrast-enhanced ultrasound (CEUS) microvascular volume (MV), Victorian Institute of Sports Assessment-Achilles (VISA-A) scores and intrinsic Achilles tendon tenderness, as well as two different Power Doppler modes. DESIGN: Cross-sectional study...
May 15, 2018: Journal of Science and Medicine in Sport
https://www.readbyqxmd.com/read/29785382/matador-injury-case-report-spermatic-cord-fat-pad-scfp-interposition-to-support-complex-pelvic-reconstruction-a-novel-technique
#3
Alexandra Zachou, Kien A Mteta, Philip J Thomas
No abstract text is available yet for this article.
May 2018: Urology Case Reports
https://www.readbyqxmd.com/read/29777756/peroxiredoxin-5-regulates-adipogenesis-attenuating-oxidative-stress-in-obese-mouse-models-induced-by-a-high-fat-diet
#4
Mi Hye Kim, Sun-Ji Park, Jung-Hak Kim, Jung Bae Seong, Kyung-Min Kim, Hyun Ae Woo, Dong-Seok Lee
Elevated levels of reactive oxygen species (ROS) are a hallmark of obesity. Peroxiredoxin 5 (Prx5), which is a cysteine-dependent peroxidase enzyme, has an intensive ROS scavenging activity because it is located in the cytosol and mitochondria. Therefore, we focused on the role of Prx5 in regulating mitochondrial ROS and adipogenesis. We demonstrated that Prx5 expression was upregulated during adipogenesis and Prx5 overexpression suppressed adipogenesis by regulating cytosolic and mitochondrial ROS generation...
May 16, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29777149/stretching-reduces-tumor-growth-in-a-mouse-breast-cancer-model
#5
L Berrueta, J Bergholz, D Munoz, I Muskaj, G J Badger, A Shukla, H J Kim, J J Zhao, H M Langevin
There is growing interest in developing non-pharmacological treatments that could boost natural defenses against cancer and contribute to primary and secondary cancer prevention. Recent studies have shown that gentle daily stretching for 10 minutes can reduce local connective tissue inflammation and fibrosis. Because mechanical factors within the stroma can influence the tumor microenvironment, we hypothesized that stretching would reduce the growth of tumors implanted within locally stretched tissues and tested this hypothesis in a mouse orthotopic breast cancer model...
May 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29776647/-effect-of-green-alga-ulva-lactuca-polysaccharides-supplementation-on-blood-pressure-and-on-atherogenic-risk-factors-in-rats-fed-a-high-fat-diet
#6
Z I Tair, F Bensalah, F Boukortt
AIM OF THE STUDY: To highlight the benefits of green alga Ulva lactuca polysaccharides supplementation on blood pressure and atherogenic risk factors in rats fed a high fat diet. METHODS: Wistar male rats were fed a high fat diet (30% sheep fat) for 3 months. At an average body weight (BW) of 360g, the rats (n=18) were divided into 3 groups and consumed, for 28 days, either a high fat diet (HFD) or a high fat diet enriched with 1% of whole green algae (WGA) powder or with 1% of its polysaccharides (PLS)...
May 15, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29774599/deep-convolutional-neural-network-for-segmentation-of-knee-joint-anatomy
#7
Zhaoye Zhou, Gengyan Zhao, Richard Kijowski, Fang Liu
PURPOSE: To describe and evaluate a new segmentation method using deep convolutional neural network (CNN), 3D fully connected conditional random field (CRF), and 3D simplex deformable modeling to improve the efficiency and accuracy of knee joint tissue segmentation. METHODS: A segmentation pipeline was built by combining a semantic segmentation CNN, 3D fully connected CRF, and 3D simplex deformable modeling. A convolutional encoder-decoder network was designed as the core of the segmentation method to perform high resolution pixel-wise multi-class tissue classification for 12 different joint structures...
May 17, 2018: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/29773398/sulfated-polysaccharide-mediated-tgf-%C3%AE-1-presentation-in-pre-formed-injectable-scaffolds-for-cartilage-tissue-engineering
#8
Neha Ashok Waghmare, Aditya Arora, Arijit Bhattacharjee, Dhirendra S Katti
In this work, a plant-derived polysaccharide carboxymethylcellulose (CMC) was chemically modified to incorporate sulfate groups to facilitate binding of cationic growth factors. The sulfated CMC (heparin mimic) was then used with CMC (glycosaminoglycan mimic) and gelatin (collagen mimic) to fabricate injectable pre-formed, macroporous scaffolds for cartilage tissue engineering. These scaffolds demonstrated high resilience and shape memory, thereby making them injectable through a 14G needle for up to 4-6 aspiration and injection cycles...
August 1, 2018: Carbohydrate Polymers
https://www.readbyqxmd.com/read/29769776/root-coverage-with-buccal-fat-pad-placed-on-restored-cervical-abrasion-case-report-with-three-year-follow-up
#9
Harpreet Singh Grover, Sagrika Shukla, Ashi Chug, Kuldeep Singh
A patient was reported with Class II gingival recession (GR) of 5 mm. After restoring abrasion with glass ionomer cement, a full-thickness flap was raised and using blunt dissection through the buccinator and loose surrounding fascia buccal fat pad (BFP) was exposed into the mouth. It was easily spread over the maxillary roots of 14, 15, and 16. It was secured and immobilized using sutures. Postoperatively, the patient did not report swelling or trismus. At 3-year postoperative, gingival margin was at cementoenamel junction, stable and healthy and did not show any recession...
March 2018: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29769086/inflammatory-pattern-of-the-infrapatellar-fat-pad-in-dogs-with-canine-cruciate-ligament-disease
#10
Manuel R Schmidli, Bettina Fuhrer, Nadine Kurt, David Senn, Michaela Drögemüller, Ulrich Rytz, David E Spreng, Simone Forterre
BACKGROUND: Despite the importance of inflammation during the pathogenesis of cranial cruciate ligament disease (CCLD) in dogs and despite the latest knowledge suggesting a significant role of adipose tissue in osteoarthritis, the infrapatellar fat pad (IFP) was up to now mostly disregarded in veterinary investigations. In the present study, the inflammatory activity of the IFP, the main adipose structure within the stifle joint, was thoroughly investigated to evaluate its potential impact in the pathogenesis of this common disease of our canine companions...
May 16, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29765427/adipose-derived-mesenchymal-stem-cells-in-the-use-of-cartilage-tissue-engineering-the-need-for-a-rapid-isolation-procedure
#11
REVIEW
Sam L Francis, Serena Duchi, Carmine Onofrillo, Claudia Di Bella, Peter F M Choong
Mesenchymal stem cells (MSCs) have shown much promise with respect to their use in cartilage tissue engineering. MSCs can be obtained from many different tissue sources. Among these, adipose tissue can provide an abundant source of adipose-derived mesenchymal stem cells (ADMSCs). The infrapatellar fat pad (IFP) is a promising source of ADMSCs with respect to producing a cartilage lineage. Cell isolation protocols to date are time-consuming and follow conservative approaches that rely on a long incubation period of 24-48 hours...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29762121/friction-syndromes-of-the-knee-the-iliotibial-band-and-anterior-fat-pads
#12
Robert D Wissman, Stephen J Pomeranz
As participation in sporting activities increases among the general population, the incidence of overuse injuries continues to rise. Friction syndromes of the knee are common and are often clinically diagnosed without the need for imaging. However, clinical symptoms may overlap with other joint abnormalities, and physical examination may be limited in individuals with excessive pain. Magnetic resonance imaging has remained the modality of choice for the evaluation of internal derangements of the joints and is a useful aid in the diagnosis of friction syndrome of the knee...
2018: Journal of Surgical Orthopaedic Advances
https://www.readbyqxmd.com/read/29761471/the-infrapatellar-fat-pad-and-the-synovial-membrane-an-anatomo-functional-unit
#13
REVIEW
Veronica Macchi, Elena Stocco, Carla Stecco, Elisa Belluzzi, Marta Favero, Andrea Porzionato, Raffaele De Caro
The infrapatellar pad, a fibro-adipose tissue with peculiar microscopic and mechanical features, is gaining wide attention in the field of rheumatological research. The purpose of this descriptive review is to summarize the most recent published evidence on the anatomic, physiologic and biomechanical inter-relationship between the infrapatellar fat pad and the knee synovial membrane. As an extrasynovial tissue, the infrapatellar fat pad does not directly interact with the articular cartilage; based on its location in close contact with the synovial membrane, and due to the metabolic properties of adipose tissue, it may influence the behavior of the synovial membrane...
May 14, 2018: Journal of Anatomy
https://www.readbyqxmd.com/read/29753949/associations-between-knee-structural-measures-circulating-inflammatory-factors-and-mmp13-in-patients-with-knee-osteoarthritis
#14
Guangfeng Ruan, Jianhua Xu, Kang Wang, Juan Wu, Qicui Zhu, Jiale Ren, Fuqin Bian, Bingru Chang, Xiaochun Bai, Weiyu Han, Changhai Ding
OBJECTIVE: To investigate cross-sectional associations between serum level of MMP13 and knee structural measures and circulating inflammatory factors in patients with symptomatic knee osteoarthritis (OA). DESIGN: A total of 149 subjects with symptomatic knee OA were included. Magnetic resonance imaging was used to measure infrapatellar fat pad (IPFP) volume, IPFP signal intensity alternation, cartilage volume and cartilage defects. Knee radiography was used to assess radiographic OA using the Kellgren-Lawrence (K-L) grading system...
May 10, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29748692/clinics-in-diagnostic-imaging-185
#15
Ying Xin Candice Leong, Poh Lye Paul See
A 20-year-old National Serviceman presented with left knee pain and swelling after training for his physical fitness test. Lateral knee radiography and magnetic resonance (MR) imaging showed patellar tendon-lateral femoral condyle friction syndrome (PT-LFCFS), on a background of patella alta and patellar malalignment. The patient was treated non-operatively with a course of physiotherapy and given advice on rest and activity modification. PT-LFCFS is a less well-recognised but important cause of anterior knee pain and represents an entity in a spectrum of disorders related to patellofemoral instability...
April 2018: Singapore Medical Journal
https://www.readbyqxmd.com/read/29746842/does-the-deep-layer-of-the-deep-temporalis-fascia-really-exist
#16
Hui Li, Kaide Li, Wenhao Jia, Chaoying Han, Jinlong Chen, Lei Liu
PURPOSE: It has been widely accepted that a split of the deep temporal fascia occurs approximately 2 to 3 cm above the zygomatic arch and extends into the superficial and deep layers. The deep layer of the deep temporal fascia is between the superficial temporal fat pad and the temporal muscle. However, during procedures, the authors noted the absence of the deep layer of the deep temporal fascia between the superficial temporal fat pad and the temporal muscle. This prospective study was conducted to clarify the presence or absence of a deep layer of the deep temporal fascia...
April 14, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29736411/a-functional-genomic-screen-in-vivo-identifies-ceacam5-as-a-clinically-relevant-driver-of-breast-cancer-metastasis
#17
Emily Powell, Jiansu Shao, Hector M Picon, Christopher Bristow, Zhongqi Ge, Michael Peoples, Frederick Robinson, Sabrina L Jeter-Jones, Christopher Schlosberg, Caitlin L Grzeskowiak, Fei Yang, Yun Wu, Ignacio Wistuba, Stacy L Moulder, William F Symmans, Kenneth L Scott, John R Edwards, Han Liang, Timothy P Heffernan, Helen Piwnica-Worms
Tumor cells disseminate early in tumor development making metastasis-prevention strategies difficult. Identifying proteins that promote the outgrowth of disseminated tumor cells may provide opportunities for novel therapeutic strategies. Despite multiple studies demonstrating that the mesenchymal-to-epithelial transition (MET) is critical for metastatic colonization, key regulators that initiate this transition remain unknown. We serially passaged lung metastases from a primary triple negative breast cancer xenograft to the mammary fat pads of recipient mice to enrich for gene expression changes that drive metastasis...
2018: NPJ Breast Cancer
https://www.readbyqxmd.com/read/29730509/protein-restriction-diet-during-the-suckling-phase-programs-rat-metabolism-against-obesity-and-insulin-resistance-exacerbation-induced-by-a-high-fat-diet-in-adulthood
#18
Isabela Peixoto Martins, Júlio Cezar de Oliveira, Audrei Pavanello, Camila Cristina Ianoni Matiusso, Carina Previate, Laize Peron Tófolo, Tatiane Aparecida Ribeiro, Claudinéia Conationi da Silva Franco, Rosiane Aparecida Miranda, Kelly Valério Prates, Vander Silva Alves, Flávio Andrade Francisco, Ana Maria Praxedes de Moraes, Paulo Cezar de Freitas Mathias, Ananda Malta
Protein restriction during the suckling phase can malprogram rat offspring to a lean phenotype associated with metabolic dysfunctions later in life. We tested whether protein-caloric restriction during lactation can exacerbate the effect of a high-fat (HF) diet at adulthood. To test this hypothesis, we fed lactating Wistar dams with a low-protein (LP; 4% protein) diet during the first 2 weeks of lactation or a normal-protein (NP; 23% protein) diet throughout lactation. Rat offspring from NP and LP mothers received a normal-protein diet until 60 days old...
April 3, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29727209/perturbation-of-epithelial-apicobasal-polarity-by-rhomboid-family-1-gene-overexpression
#19
Xue-Mei Peng, Shan Gao, Hui-Ting Deng, Hong-Xing Cai, Zhuan Zhou, Rong Xiang, Qiang-Zhe Zhang, Lu-Yuan Li
The human rhomboid family (RHBDF)1 gene is highly expressed in breast cancer under clinical conditions but not in normal mammary gland tissues. Silencing the RHBDF1 gene in breast cancer xenograft tumors leads to inhibition of tumor growth. We show in this study that artificially raising RHBDF1 protein levels in the mammary epithelial cells MCF-10A results in severe perturbations of the ability of the cells to form lumen-containing acini, either in 3-dimensional cell cultures or implanted in mouse mammary fat pads...
May 4, 2018: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/29723251/spatiotemporal-assessment-of-spontaneous-metastasis-formation-using-multimodal-in-vivo-imaging-in-her2-and-triple-negative-metastatic-breast-cancer-xenograft-models-in-mice
#20
Inga B Fricke, Raquel De Souza, Lais Costa Ayub, Giulio Francia, Robert Kerbel, David A Jaffray, Jinzi Zheng
BACKGROUND: Preclinical breast cancer models recapitulating the clinical course of metastatic disease are crucial for drug development. Highly metastatic cell lines forming spontaneous metastasis following orthotopic implantation were previously developed and characterized regarding their biological and histological characteristics. This study aimed to non-invasively and longitudinally characterize the spatiotemporal pattern of metastasis formation and progression in the MDA-MB-231-derived triple negative LM2-4 and HER2+ LM2-4H2N cell lines, using bioluminescence imaging (BLI), contrast enhanced computed tomography (CT), fluorescence imaging, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose positron emission tomography ([18F]FDG-PET)...
2018: PloS One
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