Ingeborg Rasing, Sabine Voigt, Emma A Koemans, Anna M de Kort, Thijs W van Harten, Ellis S van Etten, Erik W van Zwet, Erik Stoops, Cindy Francois, Bea H Kuiperij, Catharina J M Klijn, Floris H B M Schreuder, Louise van der Weerd, Matthias J P van Osch, Marianne A A van Walderveen, Marcel M Verbeek, Gisela M Terwindt, Marieke J H Wermer
BACKGROUND: Neurofilament light chain (NFL) is a biomarker for neuroaxonal damage and glial fibrillary acidic protein (GFAP) for reactive astrocytosis. Both processes occur in cerebral amyloid angiopathy (CAA), but studies investigating the potential of NFL and GFAP as markers for CAA are lacking. We aimed to investigate NFL and GFAP as biomarkers for neuroaxonal damage and astrocytosis in CAA. METHODS: For this cross-sectional study serum and cerebrospinal fluid (CSF) samples were collected between 2010 and 2020 from controls, (pre)symptomatic Dutch-type hereditary (D-CAA) mutation-carriers and participants with sporadic CAA (sCAA) from two prospective CAA studies at two University hospitals in the Netherlands...
April 23, 2024: Alzheimer's Research & Therapy