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Light therapy

M S Eng, J Kaur, L Prasmickaite, B Ø Engesæter, A Weyergang, E Skarpen, K Berg, M G Rosenblum, G M Mælandsmo, A Høgset, S Ferrone, P K Selbo
Triple-negative breast cancer (TNBC) and malignant melanoma are highly aggressive cancers that widely express the cell surface chondroitin sulfate proteoglycan 4 (CSPG4/NG2). CSPG4 plays an important role in tumor cell growth and survival and promotes chemo- and radiotherapy resistance, suggesting that CSPG4 is an attractive target in cancer therapy. In the present work, we applied the drug delivery technology photochemical internalization (PCI) in combination with the novel CSPG4-targeting immunotoxin 225...
March 22, 2018: Photochemical & Photobiological Sciences
Guangbao Yang, Ligeng Xu, Jun Xu, Rui Zhang, Guosheng Song, Yu Chao, Liangzhu Feng, Fengxuan Han, Ziliang Dong, Bin Li, Zhuang Liu
Photodynamic therapy (PDT) is an oxygen-dependent light-triggered non-invasive therapeutic method showing many promising aspects in cancer treatment. For effective PDT, nanoscale carriers are often needed to realize tumor-targeted delivery of photosensitizers, which ideally should further target specific cell organelles that are most vulnerable to reactive oxygen species (ROS). Secondly, as oxygen is critical for PDT-induced cancer destruction, overcoming hypoxia existing in majority of solid tumors is important for optimizing PDT efficacy...
March 22, 2018: Nano Letters
Yu-Ling Zou, Wen-Bin Luo, Lin Xie, Xin-Bang Mao, Chao Wu, Zhi-Peng You
PURPOSE: Diabetic retinopathy (DR) is a major vision threatening disease mainly induced by high glucose. Despite great efforts were made to explore the etiology of DR, the exact mechanism responsible for its pathogenesis remains elusive. METHODS: In our study, we constructed diabetic rats via Streptozotocin (STZ) injection. TUNEL assay was employed to examine retinal cell apoptosis. The levels of mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were analyzed via flow cytometry...
March 21, 2018: Endocrine
Ilaria Cavallari, Giuseppe Patti
Platelets and the coagulation cascade play key roles in initiation, amplification, and perpetuation of acute coronary syndromes (ACS). In the past few years, there has been great progress in ACS antithrombotic treatment with the introduction of novel anticoagulants (fondaparinux and bivalirudin), more potent P2Y12 inhibitors (prasugrel and ticagrelor) and protease-activated receptor antagonists (vorapaxar). Nonetheless, patients with ACS frequently have recurrent ischemic events despite the use of currently recommended dual antiplatelet therapy, revascularization procedures as appropriate, and other evidence-based secondary preventive measures...
March 21, 2018: Internal and Emergency Medicine
Kunyuan Tie, Yuyu Yuan, Shiqing Yan, Xi Yu, Qiuyang Zhang, Huihui Xu, Yang Zhang, Jingmin Gu, Changjiang Sun, Liancheng Lei, Wenyu Han, Xin Feng
Salmonella pullorum is the major pathogen that is harmful to the poultry industry in developing countries, and the treatment of chicken diarrhea caused by S. pullorum has become increasingly difficult. In this study, a virulent bacteriophage YSP2, which was able to specifically infect Salmonella, was isolated and characterized. Phage YSP2 was classified in the Siphoviridae family and had a short latent period of 10 min. No bacterial virulence- or lysogenesis-related ORF is present in the YSP2 genome, making it eligible for use in phage therapy...
March 21, 2018: Virus Genes
Wen Lin, Guoxing Xu
Increasing evidence has demonstrated that excessive blue-light (BL) with high photochemical energy and phototoxicity could induce apoptosis in retinal pigment epithelium (RPE) cells. RPE apoptosis leads to retina damage and further aggravate age-related macular degeneration (ARMD). Because of their neuroprotective, plasticity, and immunomodulatory ability, bone marrow mesenchymal stem cells (BMSCs) are recognized for retinal neuroprotection. RPE cells possess ciliary neurotrophic factor (CNTF) receptor complexes and can respond to CNTF; hence, we investigated the effects of BMSCs over-expressing CNTF on BL-injured RPE cells...
March 21, 2018: In Vitro Cellular & Developmental Biology. Animal
Parthopratim Dutta Majumder, Karpagam Damodaran, Amala Elizabeth George, Jyotirmay Biswas
A 34-year-old female a known scleroderma patient presented to us with ocular manifestations in the form choroiditis along with optic nerve involvement. Blood investigations were done, and the ocular findings were confirmed by fundus fluorescein angiography. She was successfully managed with systemic steroid therapy. Among the protean ocular manifestations in scleroderma, only a few cases of choroidal involvement have been reported. Further, clinical and histopathological studies may be needed to throw light on the exact etiopathogenesis...
January 2018: Oman Journal of Ophthalmology
Rinat O Esenaliev, Irene Y Petrov, Yuriy Petrov, Jutatip Guptarak, Deborah R Boone, Emanuele Mocciaro, Harris Weisz, Margaret O Parsley, Stacy L Sell, Helen L Hellmich, Jonathan M Ford, Connor Pogue, Douglas DeWitt, Donald S Prough, Maria Adelaide Micci
We have developed a novel, non-invasive Nano-Pulsed Laser Therapy (NPLT) system that combines the benefits of near-infrared laser light (808 nm) and ultrasound (optoacoustic) waves, which are generated with each short laser pulse within the tissue. We tested NPLT in a rat model of blast-induced neurotrauma to determine whether transcranial application of NPLT provides neuroprotective effects. The laser pulses were applied on the intact rat head one hour after injury using a specially developed fiber-optic system...
March 21, 2018: Journal of Neurotrauma
Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen, Xingchen Duan, Zhe Zheng, Dan Ding, Dong-Sheng Guo
Activatable phototheranostics is highly appealing to meet the demand of precision medicine. However, although displaying the efficacy in construction of activatable photosensitizers (PSs), direct covalent decoration still shows some inevitable issues, such as complex molecular design, tedious synthesis, possible photoactivity changes and potential toxicity. Herein, we propose a novel concept of biomarker displacement activation (BDA) using host-guest strategy. To exemplify BDA, we engineered a PS-loaded nanocarrier by utilizing a macrocyclic amphiphile, where the fluorescence and photoactivity of PS were completely annihilated by the complexation of macrocyclic receptor (OFF state)...
March 21, 2018: Journal of the American Chemical Society
Maria Mrakovcic, Leopold F Fröhlich
Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and renewal of cellular components and thereby balancing the cell's energy consumption and homeostasis. Deregulation of autophagy is now regarded as one of the characteristic key features contributing to the development of tumors. In recent years, the suppression of autophagy in combination with chemotherapeutic treatment has been approached as a novel therapy in cancer treatment. However, depending on the type of cancer and context, interference with the autophagic machinery can either promote or disrupt tumorigenesis...
March 21, 2018: Biomolecules
Mohamed Ahmed Abdel-Mohsen, Ahlam Abd-Allah El-Braky, Abeer Abd El-Rahim Ghazal, Mohammed Mohammed Shamseya
The aims of this study were to investigate the interplay between autophagy and apoptosis and to investigate the association between both of autophagy and apoptosis and vitamin D and its receptor in hepatitis C virus (HCV) viral infection and its implication in the progression into hepatocellular carcinoma (HCC).A cross-sectional study where serum levels of microtubule-associated protein 1A/1B-light chain 3 (LC3); marker of autophagy, caspase-3; marker of apoptosis, vitamin D3 and vitamin D receptor (VDR) were measured in healthy subjects as well as HCV and HCV-HCC patients using enzyme-linked immunosorbent assay technique...
March 2018: Medicine (Baltimore)
Xue Han, Yi Zhang, Lin Yin, Lin Zhang, Yue Wang, Hongshan Zhang, Bo Li
The purpose of this meta-analysis is to investigate whether statin is a key therapy for myocardial infarction (MI) by comparing all randomized controlled trials that appraised the effects of statin on risk of MI.Pubmed, Embase, and Medline databases (up to December 2016) were used to search all related articles. Using the data from 18 available publications, we examined the efficacy in treating or reducing the risk of MI by using random-effects models of odds ratio (OR) comparing the highest with the lowest category...
March 2018: Medicine (Baltimore)
Thomas W L Scheeren, Jannis N Wicke, Jean-Louis Teboul
PURPOSE OF REVIEW: The current review attempts to demonstrate the value of several forms of carbon dioxide (CO2) gaps in resuscitation of the critically ill patient as monitor for the adequacy of the circulation, as target for fluid resuscitation and also as predictor for outcome. RECENT FINDINGS: Fluid resuscitation is one of the key treatments in many intensive care patients. It remains a challenge in daily practice as both a shortage and an overload in intravascular volume are potentially harmful...
March 20, 2018: Current Opinion in Critical Care
Bayan Alemrayat, Abdelbary Elhissi, Husam M Younes
Letrozole (LTZ), an aromatase inhibitor used for the treatment of hormonally-positive breast cancer in postmenopausal women, has poor water solubility, rapid metabolism and a range of side effects. In this study, polymer-based nanoparticles (NPs) incorporating the drug have been designed and characterized, aimed to control the release, potentially maximize the therapeutic efficiency and minimize the side effects of the drug. LTZ was incorporated into Poly (D, L-Lactide) (PDLLA) NPs by employing the emulsion-solvent evaporation technique using a range of drug concentrations...
March 21, 2018: Pharmaceutical Development and Technology
Guangxue Feng, Jie Liu, Chong-Jing Zhang, Bin Liu
Cell organelle targeting is a promising approach for cancer therapy. Herein, we report a mitochondria-targeted light-up probe (TPETH-Mito-1ART) to co-deliver artemisinin (ART) and an AIE photosensitizer (PS) to mitochondria for image-guided combination cancer cell ablation. This probe contains an AIEgen core of TPETH, two mitochondria targeting arms with ART on one arm, which could be internalized into cancer cells over normal ones, and show predominant accumulation and fluorescence turn-on in mitochondria...
March 21, 2018: ACS Applied Materials & Interfaces
R Dumont, F Puleo, J Collignon, N Meurisse, M Chavez, L Seidel, P Gast, M Polus, C Loly, Ph Delvenne, P Meunier, R Hustinx, A Deroover, O Detry, E Louis, Ph Martinive, D Van Daele
BACKGROUND AND STUDY AIMS: The current standard of care for resectable pancreatic ductal adenocarcinoma (PDAC) is surgery-first followed by adjuvant chemotherapy. We review our single center experience in a PDAC cohort managed by the surgery-first strategy. We then compare our data to those of Belgian and international literature. PATIENTS METHODS: We reviewed a series of 83 consecutive resectable patients with PDAC, treated by the surgery-first approach in a Belgian Academic Hospital between 2007 and 2013...
October 2017: Acta Gastro-enterologica Belgica
Syed Rakin Ahmed, Jeremy Mengyu Jia, Petr Bruza, Sergei Vinogradov, Shudong Jiang, David J Gladstone, Lesley A Jarvis, Brian W Pogue
Radiation therapy produces Cherenkov optical emission in tissue, and this light can be utilized to activate molecular probes. The feasibility of sensing luminescence from a tissue molecular oxygen sensor from within a human body phantom was examined using the geometry of the axillary lymph node region. Detection of regions down to 30-mm deep was feasible with submillimeter spatial resolution with the total quantity of the phosphorescent sensor PtG4 near 1 nanomole. Radiation sheet scanning in an epi-illumination geometry provided optimal coverage, and maximum intensity projection images provided illustration of the concept...
March 2018: Journal of Biomedical Optics
Jacob Itzhacki, Daniel Clesse, Yannick Goumon, Eus J Van Someren, Jorge Mendoza
Seasonal affective disorder (SAD), beyond mood changes, is characterized by alterations in daily rhythms of behavior and physiology. The pathophysiological conditions of SAD involve changes in day length and its first-line treatment is bright light therapy. Animal models using nocturnal rodents have been studied to elucidate the neurobiological mechanisms of depression, but might be ill suited to study the therapeutic effects of light in SAD since they exhibit light-aversive responses. Here Arvicanthis ansorgei, a diurnal rodent, was used to determine behavioral, molecular and brain dopamine changes in response to exposure to a winter-like photoperiod consisting of a light-dark cycle with 8 h of light, under diminished light intensity, and 16 h of darkness...
March 20, 2018: Brain Structure & Function
Mans Broekgaarden, Imran Rizvi, Anne-Laure Bulin, Ljubica Petrovic, Ruth Goldschmidt, Iqbal Massodi, Jonathan P Celli, Tayyaba Hasan
Effective treatment of advanced metastatic disease remains the primary challenge in the management of inoperable pancreatic cancer. Current therapies such as oxaliplatin (OxPt)-based chemotherapy regimens (FOLFIRINOX) provide modest short-term survival improvements, yet with significant toxicity. Photodynamic therapy (PDT), a light-activated cancer therapy, demonstrated clinical promise for pancreatic cancer treatment and enhances conventional chemotherapies with non-overlapping toxicities. This study investigates the capacity of neoadjuvant PDT using a clinically-approved photosensitizer, benzoporphyrin derivative (BPD, verteporfin), to enhance OxPt efficacy in metastatic pancreatic cancer...
February 27, 2018: Oncotarget
Bian Jang, Madhappan Santha Moorthy, Panchanathan Manivasagan, Li Xu, Kyeongeun Song, Kang Dae Lee, Minseok Kwak, Junghwan Oh, Jun-O Jin
In advanced cancer therapy, the combinational therapeutic effect of photothermal therapy (PTT) using near-infrared (NIR) light-responsive nanoparticles (NPs) and anti-cancer drug delivery-mediated chemotherapy has been widely applied. In the present study, using a facile, low-cost, and solution-based method, we developed and synthesized fucoidan, a natural polymer isolated from seaweed that has demonstrated anti-cancer effect, and coated NPs with it as an ideal candidate in chemo-photothermal therapy against cancer cells...
February 27, 2018: Oncotarget
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