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https://www.readbyqxmd.com/read/27920546/chronotherapy-with-low-dose-modified-release-prednisone-for-the-management-of-rheumatoid-arthritis-a-review
#1
REVIEW
Stefano Paolo Beltrametti, Aurora Ianniello, Clara Ricci
To date, rheumatoid arthritis (RA) remains a debilitating, life-threatening disease. One major concern is morning symptoms (MS), as they considerably impair the patients' quality of life and ability to work. MS change in a circadian fashion, resembling the fluctuations of inflammatory cytokines such as interleukin-6, whose levels are higher in RA patients compared to healthy donors. Conversely, serum levels of the potent anti-inflammatory glucocorticoid cortisol are similar to that of healthy subjects, suggesting an imbalance that sustains a pro-inflammatory state...
2016: Therapeutics and Clinical Risk Management
https://www.readbyqxmd.com/read/27900440/role-of-methotrexate-chronotherapy-in-collagen-induced-rheumatoid-arthritis-in%C3%A2-rats
#2
X Wang, X Yan, F Wang, F Ge, Z Li
AIM: To explore the circadian rhythm of serum interleukin (IL)-6 in collagen-induced arthritis (CIA) rats and compare the safety and effectiveness of methotrexate (MTX) administered traditionally and via chronotherapy. METHODS: CIA rat models were immunized with bovine type II collagen. Serum IL-6 levels in normal and CIA rats were measured at 2, 6, 10, 14, 18, or 22 h after the light was turned on (HALO). MTX was administered to 6 HALO/18 HALO experimental groups of Wistar rats once daily according to the IL-6 rhythm...
November 29, 2016: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/27888640/chronotherapy-versus-conventional-statins-therapy-for-the-treatment-of-hyperlipidaemia
#3
REVIEW
Jose Manuel Izquierdo-Palomares, Jesus Maria Fernandez-Tabera, Maria N Plana, Almudena Añino Alba, Pablo Gómez Álvarez, Inmaculada Fernandez-Esteban, Luis Carlos Saiz, Pilar Martin-Carrillo, Óscar Pinar López
BACKGROUND: Elevated levels of total cholesterol and low-density lipoprotein play an important role in the development of atheromas and, therefore, in cardiovascular diseases. Cholesterol biosynthesis follows a circadian rhythm and is principally produced at night (between 12:00 am and 6:00 am). The adjustment of hypolipaemic therapy to biologic rhythms is known as chronotherapy. Chronotherapy is based on the idea that medication can have different effects depending on the hour at which it is taken...
November 26, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27888171/clinical-relevance-of-the-first-domomedicine-platform-securing-multidrug-chronotherapy-delivery-in-metastatic-cancer-patients-at-home-the-incasa-european-project
#4
Pasquale F Innominato, Sandra Komarzynski, Ali Mohammad-Djafari, Alexandre Arbaud, Ayhan Ulusakarya, Mohamed Bouchahda, Mazen Haydar, Rachel Bossevot-Desmaris, Virginie Plessis, Magali Mocquery, Davina Bouchoucha, Mehran Afshar, Jacques Beau, Abdoulaye Karaboué, Jean-François Morère, Joanna Fursse, Jordi Rovira Simon, Francis Levi
BACKGROUND: Telehealth solutions can improve the safety of ambulatory chemotherapy, contributing to the maintenance of patients at their home, hence improving their well-being, all the while reducing health care costs. There is, however, need for a practicable multilevel monitoring solution, encompassing relevant outputs involved in the pathophysiology of chemotherapy-induced toxicity. Domomedicine embraces the delivery of complex care and medical procedures at the patient's home based on modern technologies, and thus it offers an integrated approach for increasing the safety of cancer patients on chemotherapy...
November 25, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27861965/impact-of-the-circadian-clock-on-uv-induced-dna-damage-response-and-photocarcinogenesis
#5
Panshak Dakup, Shobhan Gaddameedhi
The skin is in constant exposure to various external environmental stressors, including solar ultraviolet (UV) radiation. Various wavelengths of UV light are absorbed by the DNA and other molecules in the skin to cause DNA damage and induce oxidative stress. The exposure to excessive ultraviolet (UV) radiation and/or accumulation of damage over time can lead to photocarcinogenesis and photoaging. The nucleotide excision repair (NER) system is the sole mechanism for removing UV photoproduct damage from DNA, and genetic disruption of this repair pathway leads to the photosensitive disorder xeroderma pigmentosum (XP)...
November 12, 2016: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/27845956/the-association-of-night-time-systolic-blood-pressure-with-ultrasound-markers-of-subclinical-cardiac-and-vascular-disease
#6
Anne Marie O'Flynn, Emily Ho, Eamon Dolan, Ronan J Curtin, Patricia M Kearney
INTRODUCTION: The aim of this study was to examine the association of night-time systolic blood pressure (BP) with subclinical cardiac dysfunction measured by global longitudinal strain (GLS) and subclinical vascular damage measured by carotid intima-media thickness (CIMT) and carotid plaques. METHODS: GLS was measured by speckle-tracking analysis of echocardiogram images. CIMT was measured at the distal 1 cm of the common carotid artery. The presence of carotid plaques was recorded...
November 11, 2016: Blood Pressure Monitoring
https://www.readbyqxmd.com/read/27844408/chronotherapy-for-hypertension-in-patients-with-chronic-kidney-disease-a-systematic-review-and-meta-analysis-in-non-black-patients
#7
REVIEW
Caixia Wang, Xilian Qiu, Linsheng Lv, Jianhua Huang, Shaomin Li, Tanqi Lou, Xun Liu
PURPOSE: To investigate the effects of chronotherapy on blood pressure in patients with chronic kidney disease (CKD). METHODS: We searched PUBMED, EMBASE, ASN-ONLINE, the Cochrane Library and the reference articles of published papers without language restriction, for randomized and non-randomized trials that assessed the effect of chronotherapy versus morning dosing regimen drug therapy for CKD patients with hypertension. Meta-analysis was done with random-effect models...
November 14, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27821487/circadian-clock-gene-bmal1-inhibits-tumorigenesis-and-increases-paclitaxel-sensitivity-in-tongue-squamous-cell-carcinoma
#8
Qingming Tang, Bo Cheng, Mengru Xie, Yatao Chen, Jiajia Zhao, Xin Zhou, Lili Chen
Circadian clock genes regulate cancer development and chemotherapy susceptibility. Accordingly, chronotherapy based on circadian phenotypes might be applied to improve therapeutic efficacy. In this study, we investigated whether the circadian clock gene Bmal1 inhibited tumor development and increased paclitaxel sensitivity in tongue squamous cell carcinoma (TSCC). Bmal1 expression was downregulated and its rhythmic pattern of expression was affected in TSCC samples and cell lines. Ectopic Bmal1 inhibited cell proliferation, migration and invasion in vitro and tumor growth in mouse xenograft models of TSCC...
November 7, 2016: Cancer Research
https://www.readbyqxmd.com/read/27806623/could-time-of-whole-brain-radiotherapy-delivery-impact-overall-survival-in-patients-with-multiple-brain-metastases
#9
Stephanie Chan, Leigha Rowbottom, Rachel McDonald, Liying Zhang, Georg A Bjarnason, May Tsao, Cyril Danjoux, Elizabeth Barnes, Henry Lam, Marko Popovic, Carlo DeAngelis, Edward Chow
OBJECTIVE: Whole brain radiotherapy (WBRT) is commonly used to treat brain metastases. Previous studies have explored how radiotherapy treatment time can affect response. The present study evaluated the influence of treatment time on overall survival (OS) for cancer patients receiving WBRT. METHODS: Patients who received WBRT from 2004 to 2016 were included. Demographic information including age, performance status, primary site, dose, fraction, treatment time, and date of death were collected...
October 2016: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/27771728/chronobiology-of-aging-a-mini-review
#10
Germaine Cornelissen, Kuniaki Otsuka
Aging is generally associated with weakening of the circadian system. The circadian amplitude is reduced and the circadian acrophase becomes more labile, tending to occur earlier with advancing age. As originally noted by Franz Halberg, similar features are observed in the experimental laboratory after bilateral lesioning of the suprachiasmatic nuclei, suggesting the involvement of clock genes in the aging process as they are in various disease conditions. Recent work has been shedding light on underlying pathways involved in the aging process, with the promise of interventions to extend healthy life spans...
October 22, 2016: Gerontology
https://www.readbyqxmd.com/read/27720507/a-pill-at-bedtime-and-your-heart-is-fine-bedtime-hypertension-chronotherapy-an-opportune-and-advantageous-inexpensive-treatment-strategy
#11
Roberto Manfredini, Fabio Fabbian
No abstract text is available yet for this article.
September 8, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27699644/chronotherapy-intuitive-sound-founded%C3%A2-but-not-broadly-applied
#12
Julia M Selfridge, Tetsuya Gotoh, Samuel Schiffhauer, JingJing Liu, Philip E Stauffer, Andrew Li, Daniel G S Capelluto, Carla V Finkielstein
Circadian rhythms are a collection of endogenously driven biochemical, physiological, and behavioral processes that oscillate in a 24-h cycle and can be entrained by external cues. Circadian clock molecules are responsible for the expression of regulatory components that modulate, among others, the cell's metabolism and energy consumption. In clinical practice, the regulation of clock mechanisms is relevant to biotransformation of therapeutics. Accordingly, xenobiotic metabolism and detoxification, the two processes that directly influence drug effectiveness and toxicity, are direct manifestations of the daily oscillations of the cellular and biochemical processes taking place within the gastrointestinal, hepatic/biliary, and renal/urologic systems...
October 3, 2016: Drugs
https://www.readbyqxmd.com/read/27678475/influence-of-dosing-times-on-cisplatin-induced-peripheral-neuropathy-in-rats
#13
Yoshihiro Seto, Fumiyasu Okazaki, Keiji Horikawa, Jing Zhang, Hitoshi Sasaki, Hideto To
BACKGROUND: Although cis-diamminedichloro-platinum (CDDP) exhibits strong therapeutic effects in cancer chemotherapy, its adverse effects such as peripheral neuropathy, nephropathy, and vomiting are dose-limiting factors. Previous studies reported that chronotherapy decreased CDDP-induced nephropathy and vomiting. In the present study, we investigated the influence of dosing times on CDDP-induced peripheral neuropathy in rats. METHODS: CDDP (4 mg/kg) was administered intravenously at 5:00 or 17:00 every 7 days for 4 weeks to male Sprague-Dawley rats, and saline was given to the control group...
September 27, 2016: BMC Cancer
https://www.readbyqxmd.com/read/27568854/development-of-protocatechualdehyde-proliposomes-based-sustained-release-pellets-with-improved-bioavailability-and-desired-pharmacokinetic-behavior-for-angina-chronotherapy
#14
Shuangshuang Zhang, Hongxiang Yan, Panpan Yu, Yulong Xia, Wenli Zhang, Jianping Liu
The present study was aimed to develope a proliposomal formulation to decrease the hepatic first-pass metabolism of protocatechualdehyde (PD), followed by pellet coating to modify the drug release for angina chronotherapy. PD proliposomes were prepared by depositing PD-phospholipid complex on mannitol powders to improve the drug encapsulation. Afterwards, the PD proliposomes were prepared into pellet cores via extrusion-spheronization using 10% κ-carrageenan as pelletization aid prior to the development of PD sustained-release pellets (PD-SRPs)...
October 10, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27472446/prednisolone-delivery-platforms-capsules-and-beads-combination-for-a-right-timing-therapy
#15
Andrea Cerciello, Giulia Auriemma, Silvana Morello, Rita P Aquino, Pasquale Del Gaudio, Paola Russo
In this work, a platform of alginate beads loaded with Prednisolone in hypromellose/gellan gum capsules (F6/Cps) able to delay steroidal anti-inflammatory drug (SAID) release as needed for chronotherapy of rheumatoid arthritis is proposed. Rheumatoid arthritis, showing a worsening in symptoms in the morning upon waking, is a pathology that can benefit from chronotherapy. With the aim to maximize prednisolone therapeutic action allowing the right timing of glucocorticoid therapy, different engineered microparticles (gel-beads) were manufactured using prilling (laminar jet break-up) as micro-encapsulation technique and Zn-alginate as gastroresistant carrier...
2016: PloS One
https://www.readbyqxmd.com/read/27455959/circadian-variations-in-clinical-symptoms-and-concentrations-of-inflammatory-cytokines-melatonin-and-cortisol-in-polymyalgia-rheumatica-before-and-during-prednisolone-treatment-a-controlled-observational-clinical-experimental-study
#16
Henrik Galbo, Lisbeth Kall
BACKGROUND: In contrast to rheumatoid arthritis (RA), no systematic investigation of diurnal variation has been carried out in polymyalgia rheumatica (PMR). The aim of the study was to provide the often-requested documentation of the 24-h time course of clinical symptoms in PMR and relate them to concentrations during the day of melatonin, inflammatory cytokines, and cortisol. Furthermore, the effects of 14 days of prednisolone treatment were studied. METHODS: Ten glucocorticoid-naive patients newly diagnosed with PMR and seven non-PMR control subjects were studied for 24 h before treatment and during the 14th day of treatment with 20 mg/day of prednisolone...
2016: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/27316580/dosing-time-contributes-to-chronotoxicity-of%C3%A2-clofarabine-in-mice-via-means-other-than-pharmacokinetics
#17
Jia-Jie Luan, Yu-Shan Zhang, Xiao-Yun Liu, Ya-Qin Wang, Jian Zuo, Jian-Guo Song, Wen Zhang, Wu-San Wang
To evaluate the time- and dose-dependent toxicity of clofarabine in mice and to further define the chronotherapy strategy of it in leukemia, we compared the mortality rates, LD50s, biochemical parameters, histological changes and organ indexes of mice treated with clofarabine at various doses and time points. Plasma clofarabine levels and pharmacokinetic parameters were monitored continuously for up to 8 hours after the single intravenous administration of 20 mg/kg at 12:00 noon and 12:00 midnight by high performance liquid chromatography (HPLC)-UV method...
May 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27316324/sleep-time-blood-pressure-unique-sensitive-prognostic-marker-of-vascular-risk-and-therapeutic-target-for-prevention
#18
Ramón C Hermida, Diana E Ayala, Michael H Smolensky, José R Fernández, Artemio Mojón, Francesco Portaluppi
Correlation between blood pressure (BP) and target organ damage, vascular risk, and long-term patient prognosis is stronger for measurements derived from around-the-clock ambulatory BP monitoring (ABPM) than in-clinic daytime ones. Numerous studies consistently substantiate the asleep BP mean is both an independent and much better predictor of cardiovascular disease (CVD) risk than either the awake or 24 h means. Elevated sleep-time BP, i.e., sleep-time hypertension, which can only be diagnosed by around-the-clock ABPM, is much more common than suspected, not only in patients with sleep disorders, but, among others, in those who are elderly or have type 2 diabetes, chronic kidney disease, or resistant hypertension...
April 14, 2016: Sleep Medicine Reviews
https://www.readbyqxmd.com/read/27306582/diurnal-variation-of-the-peripheral-cholinergic-antiinflammatory-function-in-mice
#19
Bo-Shi Fan, En-Hui Zhang, Ming-He Cheng, Zhao-Tang Wu, Bing Han, Jian-Guang Yu
AIMS: Cholinergic antiinflammatory (CAI) pathway functions importantly in inflammation via α7 nicotinic acetylcholine receptors (α7nAChR). The present work tested circadian rhythm in peripheral CAI activity and validities of CAI activity and glucocorticoids in chronotherapy for lipopolysaccharide (LPS)-induced shock. METHODS: Vesicular acetylcholine transporter (VAChT) expressed in liver and kidney was examined every 3 h in C57BL/6 mice. Proinflammatory cytokines in serum and survival time in shock were monitored after LPS injection every 3 h...
September 2016: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/27281712/clobazam-higher-evening-differential-dosing-as-an-add-on-therapy-in-refractory-epilepsy
#20
Sigride Thome-Souza, Jacquelyn Klehm, Michele Jackson, Navah E Kadish, Sheryl Manganaro, Iván Sánchez Fernández, Tobias Loddenkemper
PURPOSE: Clobazam treatment tailored to the timing of patient's seizures may improve seizure control. We aim to describe the safety and efficacy of higher-evening differential dose of clobazam as add-on therapy in patients with night-time/early morning seizures. METHOD: Differential dosing with higher evening dosing was started based on a high proportion of seizures (>80%) at nighttime (6p.m. to 6a.m.). Differential dosing was defined as providing more than 50% of the total daily dose of clobazam after 6p...
August 2016: Seizure: the Journal of the British Epilepsy Association
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