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Chronotherapy

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https://www.readbyqxmd.com/read/29775091/chronotherapy-of-maxacalcitol-on-skin-inflammation-induced-by-topical-12-o-tetradecanoylphorbol-13-acetate-in-mice
#1
Daisuke Yoshioka, Hitoshi Ando, Kentaro Ushijima, Masafumi Kumazaki, Akio Fujimura
In general, chronotherapy is desirable for a more effective and/or safe dosage regimen. In this study, a daily rhythm of skin vitamin D receptor (VDR) and chronotherapeutic profiles of maxacalcitol, a vitamin D analogue, were evaluated using mice with skin inflammation induced by topical 12-O-tetradecanoylphorbol-13-acetate (TPA). This study showed that skin nuclear VDR expression in TPA-treated mice has a daily rhythm with the peak at the middle of active period. The effects of maxacalcitol were greater after dosing during early to middle of active period than those after dosing during early to middle of inactive period...
May 18, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29735688/cisplatin-dna-adduct-repair-of-transcribed-genes-is-controlled-by-two-circadian-programs-in-mouse-tissues
#2
Yanyan Yang, Ogun Adebali, Gang Wu, Christopher P Selby, Yi-Ying Chiou, Naim Rashid, Jinchuan Hu, John B Hogenesch, Aziz Sancar
Cisplatin is a major cancer chemotherapeutic drug. It kills cancer cells by damaging their DNA, mainly in the form of Pt-d(GpG) diadducts. However, it also has serious side effects, including nephrotoxicity and hepatotoxicity that limit its usefulness. Chronotherapy is taking circadian time into account during therapy to improve the therapeutic index, by improving efficacy and/or limiting toxicity. To this end, we tested the impact of clock time on excision repair of cisplatin-induced DNA damage at single-nucleotide resolution across the genome in mouse kidney and liver...
May 22, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29695639/chronotherapy-with-defective-circadian-clock
#3
Yuan Zhang, Francis Lévi, Yunhua Chang
No abstract text is available yet for this article.
April 24, 2018: Aging
https://www.readbyqxmd.com/read/29691382/snord116-dependent-diurnal-rhythm-of-dna-methylation-in-mouse-cortex
#4
Rochelle L Coulson, Dag H Yasui, Keith W Dunaway, Benjamin I Laufer, Annie Vogel Ciernia, Yihui Zhu, Charles E Mordaunt, Theresa S Totah, Janine M LaSalle
Rhythmic oscillations of physiological processes depend on integrating the circadian clock and diurnal environment. DNA methylation is epigenetically responsive to daily rhythms, as a subset of CpG dinucleotides in brain exhibit diurnal rhythmic methylation. Here, we show a major genetic effect on rhythmic methylation in a mouse Snord116 deletion model of the imprinted disorder Prader-Willi syndrome (PWS). More than 23,000 diurnally rhythmic CpGs are identified in wild-type cortex, with nearly all lost or phase-shifted in PWS...
April 24, 2018: Nature Communications
https://www.readbyqxmd.com/read/29548931/chronobiological-regulation-of-psychosocial-and-physiological-outcomes-in-multiple-sclerosis
#5
REVIEW
Elisea De Somma, Rajiv W Jain, Kelvin W C Poon, Kaitlyn A Tresidder, Julia P Segal, Nader Ghasemlou
There is mounting scientific evidence showing the importance of innate biological rhythms on disease onset and progression. Perhaps the most important of these is the circadian rhythm, a cycle of oscillations lasting approximately 24 h. Recent work has shown that circadian rhythms are intrinsically linked to the immune system in a bidirectional fashion, and that disruption of these cycles can contribute to changes in pathology and quality of life (including fatigue, mood, and disability). This is particularly true in diseases of the nervous and immune systems...
May 2018: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/29525205/the-genomic-landscape-and-pharmacogenomic-interactions-of-clock-genes-in-cancer-chronotherapy
#6
Youqiong Ye, Yu Xiang, Fatma Muge Ozguc, Yoonjin Kim, Chun-Jie Liu, Peter K Park, Qingsong Hu, Lixia Diao, Yanyan Lou, Chunru Lin, An-Yuan Guo, Bingying Zhou, Li Wang, Zheng Chen, Joseph S Takahashi, Gordon B Mills, Seung-Hee Yoo, Leng Han
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of clock genes and their clinical relevance in cancer is lacking. We systematically characterized the alterations of clock genes across 32 cancer types by analyzing data from The Cancer Genome Atlas, Cancer Therapeutics Response Portal, and The Genomics of Drug Sensitivity in Cancer databases. Expression alterations of clock genes are associated with key oncogenic pathways, patient survival, tumor stage, and subtype in multiple cancer types...
March 28, 2018: Cell Systems
https://www.readbyqxmd.com/read/29423914/hypertension-new-perspective-on-its-definition-and-clinical-management-by-bedtime-therapy-substantially-reduces-cardiovascular-disease-risk
#7
REVIEW
Ramón C Hermida, Diana E Ayala, José R Fernández, Artemio Mojón, Michael H Smolensky
Diagnosis of hypertension-elevated blood pressure (BP) associated with increased cardiovascular disease (CVD) risk-and its management for decades have been based primarily on single time-of-day office BP measurements (OBPM) assumed representative of systolic (SBP) and diastolic BP (DBP) during the entire 24-hours span. Around-the-clock ambulatory blood pressure monitoring (ABPM), however, reveals BP undergoes 24-hours patterning characterized in normotensives and uncomplicated hypertensives by striking morning-time rise, 2 daytime peaks-one ~2-3 hours after awakening and the other early evening, small midafternoon nadir and 10-20% decline (BP dipping) in the asleep BP mean relative to the wake-time BP mean...
May 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29404487/profiling-of-the-circadian-metabolome-in-thioacetamide-induced-liver-cirrhosis-in-mice
#8
Koichi Fujisawa, Taro Takami, Toshihiko Matsumoto, Naoki Yamamoto, Isao Sakaida
Liver cirrhosis can disturb circadian rhythms, decreasing patient quality of life. Changes in metabolic products in cirrhosis are poorly understood. We evaluated changes in liver metabolism products using a thioacetamide-induced mouse model of liver cirrhosis exhibiting circadian rhythm disturbance. Principal component analysis indicated that the circular progression found in the control group was disrupted in the thioacetamide group, and Jonckheere-Terpstra-Kendall analysis showed an imbalanced pattern of oscillating metabolic products...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29400578/the-immune-system-as-a-chronotoxicity-target-of-the-anticancer-mtor-inhibitor-everolimus
#9
Narin Ozturk, Dilek Ozturk, Zeliha Pala-Kara, Engin Kaptan, Serap Sancar-Bas, Nurten Ozsoy, Suzan Cinar, Gunnur Deniz, Xiao-Mei Li, Sylvie Giacchetti, Francis Lévi, Alper Okyar
The circadian timing system controls many biological functions in mammals including xenobiotic metabolism, detoxification, cell proliferation, apoptosis and immune functions. Everolimus is a mammalian target of rapamycin inhibitor, whose immunosuppressant properties are both desired in transplant patients and unwanted in cancer patients, where it is indicated for its antiproliferative efficacy. Here we sought whether everolimus circadian timing would predictably modify its immunosuppressive effects so as to optimize this drug through timing...
February 5, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29360554/circadian-regulation-of-renal-function
#10
REVIEW
Jermaine G Johnston, David M Pollock
The kidneys regulate many vital functions that require precise control throughout the day. These functions, such as maintaining sodium balance or regulating arterial pressure, rely on an intrinsic clock mechanism that was commonly believed to be controlled by the central nervous system. Mounting evidence in recent years has unveiled previously underappreciated depth of influence by circadian rhythms and clock genes on renal function, at the molecular and physiological level, independent of other external factors...
May 1, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29289963/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-ii-diagnosis-and-treatment
#11
REVIEW
Adam Wichniak, Konrad S Jankowski, Michał Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
AIM: Circadian rhythm sleep-wake disorders (CRSWD) are a group of disorders, in which the timing of sleep and wakefulness significantly differs from a patient's expectations or socially acceptable times. The aimof the article is to present the current principles for the diagnosis and treatment of CRSWD in adults and children. METHOD: Guidelines proposed as CRSWD treatment standard are based on the recommendations from the scientific societies involved in the sleep research and medicine...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29277155/wnt-takes-two-to-tango-molecular-links-between-the-circadian-clock-and-the-cell-cycle-in-adult-stem-cells
#12
Toru Matsu-Ura, Sean R Moore, Christian I Hong
Like two dancers, the circadian clock and cell cycle are biological oscillators engaged in bidirectional communication, resulting in circadian clock-gated cell division cycles in species ranging from cyanobacteria to mammals. The identified mechanisms for this phenomenon have expanded beyond intracellular molecular coupling components to include intercellular connections. However, detailed molecular mechanisms, dynamics, and physiological functions of the circadian clock and cell cycle as coupled oscillators remain largely unknown...
February 2018: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29237390/chronopharmacokinetic-evaluation-of-budesonide-multiparticulate-systems
#13
Sowjanya Battu, Prasanna R Yalavarthi, Venkata S R Gopireddy, Uma M R Vattikuti, Jyothshna Devi, Harini C Vadlamudi
BACKGROUND: Poor oral absorption of budesonide limits the design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. METHODS: Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pareil seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique...
2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29231268/circadian-rhythm-in-atopic-dermatitis-pathophysiology-and-implications-for-chronotherapy
#14
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Circadian rhythm is a biological clock that controls a wide range of physiological functions throughout the body, including various skin functions. A 24-h diurnal cycle, governed by an endogenous clock in the brain, largely controls cutaneous diurnal rhythm, which external factors, including temperature, humidity, diet, and stress, also modulate locally. Circadian rhythm influences cutaneous blood flow and properties of skin barrier function, such as transepidermal water loss and capacitance, and has important implications in atopic dermatitis (AD)...
January 2018: Pediatric Dermatology
https://www.readbyqxmd.com/read/29215933/a-randomized-phase-ii-trial-of-induction-chemotherapy-followed-by-cisplatin-chronotherapy-versus-constant-rate-delivery-combined-with-radiotherapy
#15
P X Zhang, F Jin, Z L Li, W L Wu, Y Y Li, J H Long, G Y Chen, X X Chen, J Y Gan, X Y Gong, Q Y He, T Bi
Chronotherapy is no longer a novel concept in cancer treatment after approximately 20 years of development. Many clinical trials have provided strong supporting evidence that chronomodulated treatment yields better results than a traditional dosage regimen. This study aimed to evaluate the adverse reactions, effect on immune functions, and therapeutic efficacy of chronomodulated infusion versus flat intermittent infusion of cisplatin (DDP) combined with intensity-modulated radiation therapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC)...
February 2018: Chronobiology International
https://www.readbyqxmd.com/read/29144178/influence-of-a-dosing-time-on-toxicities-induced-by-docetaxel-cisplatin-and-5-fluorouracil-in-patients-with-oral-squamous-cell-carcinoma-a-cross-over-pilot-study
#16
Yoshiyuki Tsuchiya, Kentaro Ushijima, Tadahide Noguchi, Naruo Okada, Jun-Ichi Hayasaka, Yoshinori Jinbu, Hitoshi Ando, Yoshiyuki Mori, Mikio Kusama, Akio Fujimura
Docetaxel, cisplatin plus fluorouracil (DCF) regimen is a useful chemotherapy, but is sometimes withdrawn due to severe adverse effects (AE). In this study, we examined whether the chronotherapy of DCF regimen could reduce the drugs-induced toxicities in clinical practice. Patients with oral squamous cell carcinoma were enrolled. Chemotherapy started at 10:30 (Morning-dosing) or 18:30 (Evening-dosing) for 5 days by a cross-over design. AE were assessed for 14 days after an initiation of each dosing. The grades of nausea, vomiting and neutropenia were smaller during Evening-dosing than during Morning-dosing...
February 2018: Chronobiology International
https://www.readbyqxmd.com/read/29064793/-experience-and-comparison-of-antihypertensive-effect-of-ace-inhibitor-spirapril-and-calcium-antagonist-amlodipinein-standard-and-chronotherapeutic-prescription-mode
#17
Halyna O Ovchan, Viktoriya M Khomenko, Inna I Andrushko, Olena I Ostapchuk, Lidia M Kyrychenko
Arterial pressure is an effect of many physiologic processes of organism effected by daily rhytmus. The introduction of round the 24-hour monitoring of arterial pressure enabled to detect arterial pressure circular fluctuation. Chronotherapy with the application of amlodipin and spirapril due to the data of round the 24-hour arterial pressure monitoring increases the effectiveness of antihypertensive therapy.
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29056774/glucocorticoid-management-in-rheumatoid-arthritis-morning-or-night-low-dose
#18
REVIEW
Sabrina Paolino, Maurizio Cutolo, Carmen Pizzorni
Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up-regulation of the immune/inflammatory reaction has been shown more effective when exogenous glucocorticoid administration is managed with a night-time-release formulation...
2017: Reumatologia
https://www.readbyqxmd.com/read/29053034/circadian-rest-activity-rhythm-in-chronic-obstructive-pulmonary-disease
#19
Deuzilane Muniz Nunes, Bruno S B Gonçalves, Carina Aparecida Tardelli Peixoto, Veralice Meireles Sales De Bruin, Fernando Mazzilli Louzada, Pedro Felipe Carvalhedo De Bruin
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0...
2017: Chronobiology International
https://www.readbyqxmd.com/read/29039812/molecular-aspects-of-circadian-pharmacology-and-relevance-for-cancer-chronotherapy
#20
REVIEW
Narin Ozturk, Dilek Ozturk, Ibrahim Halil Kavakli, Alper Okyar
The circadian timing system (CTS) controls various biological functions in mammals including xenobiotic metabolism and detoxification, immune functions, cell cycle events, apoptosis and angiogenesis. Although the importance of the CTS is well known in the pharmacology of drugs, it is less appreciated at the clinical level. Genome-wide studies highlighted that the majority of drug target genes are controlled by CTS. This suggests that chronotherapeutic approaches should be taken for many drugs to enhance their effectiveness...
October 17, 2017: International Journal of Molecular Sciences
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