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https://www.readbyqxmd.com/read/28667474/development-and-in-vitro-in-vivo-characterization-of-chronomodulated-pulsatile-delivery-formulation-of-terbutaline-sulphate-by-box-behnken-statistical-design
#1
Prabhjot Singh Bajwa, Anurag Bhargava, Jaya Sharma, Shailesh Sharma, Abhimanyu Rai Sharma, Binu Sharma
In the present study, we have designed a press-coated pulsatile delivery tablet (PDT) of Terbutaline sulphate (TS) intended for prevention of early-morning asthma attacks. The formulation is capable of giving burst release of drug after 6 h of lag time. In this study, a press-coating technique was employed to coat a fast-release core tablet containing TS with a polymeric release retarding coat comprising of ethyl cellulose, HPMC K15M and Carbopol 971P. Fast-release core tablets were formulated using sodium starch glycolate with croscarmellose sodium (disintegrants)...
June 30, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28550603/development-of-novel-high-density-gastroretentive-multiparticulate-pulsatile-tablet-of-clopidogrel-bisulfate-using-quality-by-design-approach
#2
Nilesh Desai, Ravindra Purohit
Myocardial infarction, i.e., heart attack, is a fatal condition which is on the increase all over the world. It is reported that a large number of heart attack occur in morning hours which are attributable to platelet aggregation. Chronotherapy at this stage can be crucial. Clopidogrel bisulfate (CLB) is an antiplatelet agent and has become a drug of choice for prevention of heart attack. It is soluble in acidic pH and has a narrow absorption window. So, its long residence time in stomach is desirable. Therefore, a novel high density tablet was developed comprising multiparticulate pellets with pulsatile release necessary to maintain chronotherapy of heart attack...
May 26, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/28510251/short-term-effects-of-green-tea-chronotherapy-on-the-metabolic-homeostasis-of-mice-on-different-diets
#3
R P Amorim, I P Daher, F P D Arcangelo, M F Bellini, W A Orcini, G R Sarria, R L Peruquetti
Biological rhythms can be defined as changes in physiological or behavioral variables that repeat at certain time intervals. Rhythms that last approximately 24 h are referred to as circadian rhythms. Modern lifestyles have drastically affected human habits, as well as the population's eating habits. These changes have generated an epidemic of metabolic syndromes, such as obesity and diabetes. In an attempt to combat obesity, populations have attempted to use many different herbal remedies and plant-based drugs, the most common of which is Camellia sinensis, or green tea...
May 10, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28508438/the-effect-of-chronotherapy-on-delirium-in-critical-care%C3%A2-%C3%A2-a-systematic-review
#4
Roseanne Luther, Anne McLeod
BACKGROUND: Delirium is highly prevalent within critical care and is linked to adverse clinical outcomes, increased mortality and impaired quality of life. Development of delirium is thought to be caused by multiple risk factors, including disruption of the circadian rhythm. Chronotherapeutic interventions, such as light therapy, music and use of eye shades, have been suggested as an option to improve circadian rhythm within intensive care units. AIM: This review aims to answer the question: Can chronotherapy reduce the prevalence of delirium in adult patients in critical care? DESIGN: This study is a systematic review of quantitative studies...
May 15, 2017: Nursing in Critical Care
https://www.readbyqxmd.com/read/28487482/compass-in-the-data-ocean-toward-chronotherapy
#5
Rikuhiro G Yamada, Hiroki R Ueda
No abstract text is available yet for this article.
May 16, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28452285/daily-light-exposure-patterns-reveal-phase-and-period-of-the-human-circadian-clock
#6
Tom Woelders, Domien G M Beersma, Marijke C M Gordijn, Roelof A Hut, Emma J Wams
Light is the most potent time cue that synchronizes (entrains) the circadian pacemaker to the 24-h solar cycle. This entrainment process is an interplay between an individual's daily light perception and intrinsic pacemaker period under free-running conditions. Establishing individual estimates of circadian phase and period can be time-consuming. We show that circadian phase can be accurately predicted (SD = 1.1 h for dim light melatonin onset, DLMO) using 9 days of ambulatory light and activity data as an input to Kronauer's limit-cycle model for the human circadian system...
June 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/28440811/evaluation-of-circadian-phenotypes-utilizing-fibroblasts-from-patients-with-circadian-rhythm-sleep-disorders
#7
A Hida, Y Ohsawa, S Kitamura, K Nakazaki, N Ayabe, Y Motomura, K Matsui, M Kobayashi, A Usui, Y Inoue, H Kusanagi, Y Kamei, K Mishima
We evaluated the circadian phenotypes of patients with delayed sleep-wake phase disorder (DSWPD) and non-24-hour sleep-wake rhythm disorder (N24SWD), two different circadian rhythm sleep disorders (CRSDs) by measuring clock gene expression rhythms in fibroblast cells derived from individual patients. Bmal1-luciferase (Bmal1-luc) expression rhythms were measured in the primary fibroblast cells derived from skin biopsy samples of patients with DSWPD and N24SWD, as well as control subjects. The period length of the Bmal1-luc rhythm (in vitro period) was distributed normally and was 22...
April 25, 2017: Translational Psychiatry
https://www.readbyqxmd.com/read/28439594/the-effect-of-chronotherapy-on-depressive-symptoms-evidence-based-practice
#8
Anas H Khalifeh
The global prevalence of depression is increasing, along with rates of depression-associated disability and mortality, rendering depressive disorders a major public health issue. Chronotherapy involves a variety of strategies that control exposure to environmental stimuli that influence the biological clock, such as sleep deprivation (SD) or wake therapy (WT), sleep phase advance (SPA), and light and dark therapy (LT, DT). The purpose of this Evidence-Based Practice (EBP) paper is to answer PICOT questions by a review the effectiveness of chronotherapeutics interventions on depressive symptoms with depression and the depressive episode in the course of bipolar disorder...
May 2017: Saudi Medical Journal
https://www.readbyqxmd.com/read/28413970/optimizing-the-management-of-uncontrolled-resistant-hypertension-the-importance-of-sleep-apnoea-syndrome
#9
Jacek Wolf, Krzysztof Narkiewicz
Obstructive sleep apnoea (OSA) constitutes the most prevalent form of abnormal respiratory control during sleep in adults. Evidence linked OSA to cardiovascular disease, and the role of OSA in abnormal blood pressure (BP) control has been extensively studied. Although longitudinal trials suggest a causative role of OSA in the development of hypertension, the evidence is not fully consistent. Nasal continuous positive airway pressure (nCPAP) applied during sleep is well documented and a highly efficient therapeutic aid to eliminate OSA...
April 14, 2017: Current Vascular Pharmacology
https://www.readbyqxmd.com/read/28360059/the-chronotherapy-of-hypertension-or-the-benefit-of-taking-blood-pressure-tablets-at-bedtime
#10
Gervase Vernon
No abstract text is available yet for this article.
April 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/28356031/old-but-good-modified-release-prednisone-in-rheumatoid-arthritis
#11
Francesco Ursini, Saverio Naty, Caterina Bruno, Rosa Daniela Grembiale
Since more than 50 years glucocorticoids represent the milestone in the treatment of inflammatory diseases, including rheumatoid arthritis (RA). However, many patients with RA present a circadian rhythm in symptoms severity, with a significant worsening in the morning, that correlates with cyclic changes in circulating hormones and cytokines. Classical steroids therapy given in the morning fails to intercept this pathophysiological phenomenon. In the last years, a novel formulation of prednisone has been developed in order to better fit these variations, improve efficacy and minimize adverse events (chronotherapy)...
March 28, 2017: Reviews on Recent Clinical Trials
https://www.readbyqxmd.com/read/28351863/systems-chronotherapeutics
#12
REVIEW
Annabelle Ballesta, Pasquale F Innominato, Robert Dallmann, David A Rand, Francis A Lévi
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms, which moderate xenobiotic metabolism and cellular drug response. The molecular clocks present in individual cells involve approximately fifteen clock genes interconnected in regulatory feedback loops. They are coordinated by the suprachiasmatic nuclei, a hypothalamic pacemaker, which also adjusts the circadian rhythms to environmental cycles. As a result, many mechanisms of diseases and drug effects are controlled by the circadian timing system...
April 2017: Pharmacological Reviews
https://www.readbyqxmd.com/read/28275295/investigation-of-mitigating-effect-of-colon-specific-prodrugs-of-boswellic-acid-on-2-4-6-trinitrobenzene-sulfonic-acid-induced-colitis-in-wistar-rats-design-kinetics-and-biological-evaluation
#13
Ajinkya Sarkate, Suneela S Dhaneshwar
AIM: To develop a colon-targeting bioreversible delivery system for β-boswellic acid (BBA) and explore utility of its prodrugs in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis in rats. METHODS: Synthesis of 4 co-drugs of BBA with essential amino acids was achieved by CDI coupling, followed by their spectral characterization. In vitro kinetics were studied by HPLC in aqueous buffers, homogenates of gastrointestinal tract and fecal matter. In vivo kinetic studies were performed in Wistar rat plasma, urine and feces...
February 21, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28268596/evaluation-of-multidrug-cancer-chronotherapy-based-on-cell-cycle-model-under-influences-of-circadian-clock
#14
Hiroshi Inokawa, Norihiro Katayama, Mitsuyuki Nakao
The intracellular circadian clock mechanisms are known to affect various substantial cellular machinery such as cell cycle progression, inflammatory response, apoptosis, and DNA repair. Cancer growth in various tissues is still under circadian control, which may be at least partly underlain by the survived connections between the intracellular machinery and the clock. Considering such findings, chronotherapy has been applied to cancer treatments, in which anti-cancer drugs are administered in scheduled circadian times so as to resolve the trade-off between damages against the normal and cancer cells...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28226775/evaluation-of-multidrug-cancer-chronotherapy-based-on-cell-cycle-model-under-influences-of-circadian-clock
#15
Hiroshi Inokawa, Norihiro Katayama, Mitsuyuki Nakao, Hiroshi Inokawa, Norihiro Katayama, Mitsuyuki Nakao, Mitsuyuki Nakao, Hiroshi Inokawa, Norihiro Katayama
The intracellular circadian clock mechanisms are known to affect various substantial cellular machinery such as cell cycle progression, inflammatory response, apoptosis, and DNA repair. Cancer growth in various tissues is still under circadian control, which may be at least partly underlain by the survived connections between the intracellular machinery and the clock. Considering such findings, chronotherapy has been applied to cancer treatments, in which anti-cancer drugs are administered in scheduled circadian times so as to resolve the trade-off between damages against the normal and cancer cells...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28184234/exploring-diurnal-variation-using-piecewise-linear-splines-an-example-using-blood-pressure
#16
Jamie M Madden, Xia Li, Patricia M Kearney, Kate Tilling, Anthony P Fitzgerald
BACKGROUND: There are many examples of physiological processes that follow a circadian cycle and researchers are interested in alternative methods to illustrate and quantify this diurnal variation. Circadian blood pressure (BP) deserves additional attention given uncertainty relating to the prognostic significance of BP variability in relation to cardiovascular disease. However, the majority of studies exploring variability in ambulatory blood pressure monitoring (ABPM) collapse the data into single readings ignoring the temporal nature of the data...
2017: Emerging Themes in Epidemiology
https://www.readbyqxmd.com/read/28164170/ambulatory-blood-pressure-in-chronic-kidney-disease-ready-for-prime-time
#17
Manuel T Velasquez, Srinivasan Beddhu, Ehsan Nobakht, Mahboob Rahman, Dominic S Raj
Hypertension is common in patients with chronic kidney disease (CKD) and is the most important modifiable risk factor for CKD progression and adverse cardiovascular events in these patients. Diagnosis and successful management of hypertension are critically dependent on accurate blood pressure (BP) measurement. This is most relevant to CKD patients, in whom BP control is difficult to achieve and in whom early antihypertensive treatment is imperative to prevent kidney and cardiovascular complications. Accumulated data indicate that ambulatory blood pressure monitoring (ABPM) is better in detecting hypertension than office BP measurement...
July 2016: KI Reports
https://www.readbyqxmd.com/read/28064405/a-systematic-review-of-circadian-function-chronotype-and-chronotherapy-in-attention-deficit-hyperactivity-disorder
#18
REVIEW
Andrew N Coogan, Niall M McGowan
Reports of sleep disturbances in attention deficit hyperactivity disorder (ADHD) are common in both children and adults; however, the aetiology of such disturbances is poorly understood. One potentially important mechanism which may be implicated in disrupted sleep in ADHD is the circadian clock, a known key regulator of the sleep/wake cycle. In this systematic review, we analyse the evidence for circadian rhythm changes associated with ADHD, as well as assessing evidence for therapeutic approaches involving the circadian clock in ADHD...
January 7, 2017: Attention Deficit and Hyperactivity Disorders
https://www.readbyqxmd.com/read/28061531/effects-of-circadian-rhythms-and-treatment-times-on-the-response-of-radiotherapy-for-painful-bone-metastases
#19
Stephanie Chan, Liying Zhang, Leigha Rowbottom, Rachel McDonald, Georg A Bjarnason, May Tsao, Elizabeth Barnes, Cyril Danjoux, Marko Popovic, Henry Lam, Carlo DeAngelis, Edward Chow
BACKGROUND: Previous studies have observed how the time of radiotherapy delivery can impact toxicities and outcomes. The goal of this study was to determine whether treatment time influenced radiotherapy response for bone metastases. METHODS: Patients who received radiation treatment to painful bone metastases from January 2000 to December 2010 were included in our analysis. Demographic and treatment information including performance status, primary site, treatment dose and fraction, and response were collected prospectively...
January 2017: Annals of Palliative Medicine
https://www.readbyqxmd.com/read/27974526/chronotherapy-for-hypertension-in-obstructive-sleep-apnoea-chosa-a-randomised-double-blind-placebo-controlled-crossover-trial
#20
RANDOMIZED CONTROLLED TRIAL
Yasmina Serinel, Brendon J Yee, Ronald R Grunstein, Keith H Wong, Peter A Cistulli, Hisatomi Arima, Craig L Phillips
BACKGROUND: Obstructive sleep apnoea (OSA) is an important cause of secondary hypertension. Nocturnal hypertension is particularly prevalent in OSA and is a strong predictor of cardiovascular mortality. Studies in patients with essential hypertension have suggested that nocturnal administration of antihypertensives improves nocturnal blood pressure (BP) without elevating daytime BP. We evaluated the efficacy of this technique in patients with OSA with stage I/II hypertension, both before and after the addition of CPAP...
June 2017: Thorax
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