keyword
MENU ▼
Read by QxMD icon Read
search

Chronotherapy

keyword
https://www.readbyqxmd.com/read/29423914/hypertension-new-perspective-on-its-definition-and-clinical-management-by-bedtime-therapy-substantially-reduces-cardiovascular-disease-risk
#1
REVIEW
Ramón C Hermida, Diana E Ayala, José R Fernández, Artemio Mojón, Michael H Smolensky
Diagnosis of hypertension - elevated blood pressure (BP) associated with increased cardiovascular disease (CVD) risk - and its management for decades have been based primarily on single time-of-day office BP measurements (OBPM) assumed representative of systolic (SBP) and diastolic BP (DBP) during the entire 24h span. Around-the-clock ambulatory blood pressure monitoring (ABPM), however, reveals BP undergoes 24h patterning characterized in normotensives and uncomplicated hypertensives by striking morning-time rise, two daytime peaks - one ~2-3h after awakening and the other early evening, small mid-afternoon nadir, and 10-20% decline (BP dipping) of the asleep BP mean relative to the wake-time BP mean...
February 9, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29404487/profiling-of-the-circadian-metabolome-in-thioacetamide-induced-liver-cirrhosis-in-mice
#2
Koichi Fujisawa, Taro Takami, Toshihiko Matsumoto, Naoki Yamamoto, Isao Sakaida
Liver cirrhosis can disturb circadian rhythms, decreasing patient quality of life. Changes in metabolic products in cirrhosis are poorly understood. We evaluated changes in liver metabolism products using a thioacetamide-induced mouse model of liver cirrhosis exhibiting circadian rhythm disturbance. Principal component analysis indicated that the circular progression found in the control group was disrupted in the thioacetamide group, and Jonckheere-Terpstra-Kendall analysis showed an imbalanced pattern of oscillating metabolic products...
September 2017: Hepatology Communications
https://www.readbyqxmd.com/read/29400578/the-immune-system-as-a-chronotoxicity-target-of-the-anticancer-mtor-inhibitor-everolimus
#3
Narin Ozturk, Dilek Ozturk, Zeliha Pala-Kara, Engin Kaptan, Serap Sancar-Bas, Nurten Ozsoy, Suzan Cinar, Gunnur Deniz, Xiao-Mei Li, Sylvie Giacchetti, Francis Lévi, Alper Okyar
The circadian timing system controls many biological functions in mammals including xenobiotic metabolism, detoxification, cell proliferation, apoptosis and immune functions. Everolimus is a mammalian target of rapamycin inhibitor, whose immunosuppressant properties are both desired in transplant patients and unwanted in cancer patients, where it is indicated for its antiproliferative efficacy. Here we sought whether everolimus circadian timing would predictably modify its immunosuppressive effects so as to optimize this drug through timing...
February 5, 2018: Chronobiology International
https://www.readbyqxmd.com/read/29360554/circadian-regulation-of-renal-function
#4
REVIEW
Jermaine G Johnston, David M Pollock
The kidneys regulate many vital functions that require precise control throughout the day. These functions, such as maintaining sodium balance or regulating arterial pressure, rely on an intrinsic clock mechanism that was commonly believed to be controlled by the central nervous system. Mounting evidence in recent years has unveiled previously underappreciated depth of influence by circadian rhythms and clock genes on renal function, at the molecular and physiological level, independent of other external factors...
January 31, 2018: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/29289963/treatment-guidelines-for-circadian-rhythm-sleep-wake-disorders-of-the-polish-sleep-research-society-and-the-section-of-biological-psychiatry-of-the-polish-psychiatric-association-part-ii-diagnosis-and-treatment
#5
REVIEW
Adam Wichniak, Konrad S Jankowski, Michał Skalski, Krystyna Skwarło-Sońta, Jolanta B Zawilska, Marcin Żarowski, Ewa Poradowska, Wojciech Jernajczyk
AIM: Circadian rhythm sleep-wake disorders (CRSWD) are a group of disorders, in which the timing of sleep and wakefulness significantly differs from a patient's expectations or socially acceptable times. The aimof the article is to present the current principles for the diagnosis and treatment of CRSWD in adults and children. METHOD: Guidelines proposed as CRSWD treatment standard are based on the recommendations from the scientific societies involved in the sleep research and medicine...
October 29, 2017: Psychiatria Polska
https://www.readbyqxmd.com/read/29277155/wnt-takes-two-to-tango-molecular-links-between-the-circadian-clock-and-the-cell-cycle-in-adult-stem-cells
#6
Toru Matsu-Ura, Sean R Moore, Christian I Hong
Like two dancers, the circadian clock and cell cycle are biological oscillators engaged in bidirectional communication, resulting in circadian clock-gated cell division cycles in species ranging from cyanobacteria to mammals. The identified mechanisms for this phenomenon have expanded beyond intracellular molecular coupling components to include intercellular connections. However, detailed molecular mechanisms, dynamics, and physiological functions of the circadian clock and cell cycle as coupled oscillators remain largely unknown...
December 1, 2017: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/29237390/chronopharmacokinetic-evaluation-of-budesonide-multiparticulate-systems
#7
Sowjanya Battu, Prasanna Raju Yalavarthi, G V Subbareddy, Uma Maheswara Rao, Jyothshna Devi Katamreddy, Harini Cowdary Vadlamudi
Poor oral absorption of budesonide limits design of its solid oral dosage form. With this context, multiparticulate pulsatile system of budesonide for chronotherapy of nocturnal asthma was aimed in this study. Initially, solid dispersions of budesonide (BD) using sodium starch glycolate (SSG) and guar gum (GG) were developed and characterized. Uniform sized non-pariel seeds (~400 µm) were coated with solid dispersions to obtain immediate (BMP) and controlled release pellets by solution layering technique. Pulsatile drug release pellets (BMPP) were obtained by coating the controlled release pellets with Eudragit L100 and RS 100...
December 12, 2017: Recent Patents on Drug Delivery & Formulation
https://www.readbyqxmd.com/read/29231268/circadian-rhythm-in-atopic-dermatitis-pathophysiology-and-implications-for-chronotherapy
#8
Alexandra R Vaughn, Ashley K Clark, Raja K Sivamani, Vivian Y Shi
Circadian rhythm is a biological clock that controls a wide range of physiological functions throughout the body, including various skin functions. A 24-h diurnal cycle, governed by an endogenous clock in the brain, largely controls cutaneous diurnal rhythm, which external factors, including temperature, humidity, diet, and stress, also modulate locally. Circadian rhythm influences cutaneous blood flow and properties of skin barrier function, such as transepidermal water loss and capacitance, and has important implications in atopic dermatitis (AD)...
December 12, 2017: Pediatric Dermatology
https://www.readbyqxmd.com/read/29215933/a-randomized-phase-ii-trial-of-induction-chemotherapy-followed-by-cisplatin-chronotherapy-versus-constant-rate-delivery-combined-with-radiotherapy
#9
P X Zhang, F Jin, Z L Li, W L Wu, Y Y Li, J H Long, G Y Chen, X X Chen, J Y Gan, X Y Gong, Q Y He, T Bi
Chronotherapy is no longer a novel concept in cancer treatment after approximately 20 years of development. Many clinical trials have provided strong supporting evidence that chronomodulated treatment yields better results than a traditional dosage regimen. This study aimed to evaluate the adverse reactions, effect on immune functions, and therapeutic efficacy of chronomodulated infusion versus flat intermittent infusion of cisplatin (DDP) combined with intensity-modulated radiation therapy (IMRT) in patients with locoregionally advanced nasopharyngeal carcinoma (NPC)...
December 7, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29144178/influence-of-a-dosing-time-on-toxicities-induced-by-docetaxel-cisplatin-and-5-fluorouracil-in-patients-with-oral-squamous-cell-carcinoma-a-cross-over-pilot-study
#10
Yoshiyuki Tsuchiya, Kentaro Ushijima, Tadahide Noguchi, Naruo Okada, Jun-Ichi Hayasaka, Yoshinori Jinbu, Hitoshi Ando, Yoshiyuki Mori, Mikio Kusama, Akio Fujimura
Docetaxel, cisplatin plus fluorouracil (DCF) regimen is a useful chemotherapy, but is sometimes withdrawn due to severe adverse effects (AE). In this study, we examined whether the chronotherapy of DCF regimen could reduce the drugs-induced toxicities in clinical practice. Patients with oral squamous cell carcinoma were enrolled. Chemotherapy started at 10:30 (Morning-dosing) or 18:30 (Evening-dosing) for 5 days by a cross-over design. AE were assessed for 14 days after an initiation of each dosing. The grades of nausea, vomiting and neutropenia were smaller during Evening-dosing than during Morning-dosing...
November 16, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29064793/-experience-and-comparison-of-antihypertensive-effect-of-ace-inhibitor-spirapril-and-calcium-antagonist-amlodipinein-standard-and-chronotherapeutic-prescription-mode
#11
Halyna O Ovchan, Viktoriya M Khomenko, Inna I Andrushko, Olena I Ostapchuk, Lidia M Kyrychenko
Arterial pressure is an effect of many physiologic processes of organism effected by daily rhytmus. The introduction of round the 24-hour monitoring of arterial pressure enabled to detect arterial pressure circular fluctuation. Chronotherapy with the application of amlodipin and spirapril due to the data of round the 24-hour arterial pressure monitoring increases the effectiveness of antihypertensive therapy.
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29056774/glucocorticoid-management-in-rheumatoid-arthritis-morning-or-night-low-dose
#12
REVIEW
Sabrina Paolino, Maurizio Cutolo, Carmen Pizzorni
Morning symptoms of rheumatoid arthritis (RA) are linked to circadian increase of night inflammation, supported by inadequate cortisol secretion in active disease. Therefore, exogenous glucocorticoid administration in RA is recommended by EULAR and ACR from the beginning of the diagnosis, since may partially act like a "replacement therapy". In addition, the prevention/treatment of the night up-regulation of the immune/inflammatory reaction has been shown more effective when exogenous glucocorticoid administration is managed with a night-time-release formulation...
2017: Reumatologia
https://www.readbyqxmd.com/read/29053034/circadian-rest-activity-rhythm-in-chronic-obstructive-pulmonary-disease
#13
Deuzilane Muniz Nunes, Bruno S B Gonçalves, Carina Aparecida Tardelli Peixoto, Veralice Meireles Sales De Bruin, Fernando Mazzilli Louzada, Pedro Felipe Carvalhedo De Bruin
To characterize circadian rest-activity rhythm in COPD, 26 cases (66.9 ± 8.5y) and 15 controls (63.0 ± 10.7y) were assessed by actimetry. Rhythm fragmentation was measured by intradaily variability (IV), while synchronization to the 24-h light-dark cycle was measured by interdaily stability (IS). The average activity during the least active 5-h period (L5) and the average activity during the most active 10-h period (M10) were used to calculate the relative amplitude mean [RAm = (M10-L5)/(M10+L5)]. COPD patients presented higher IVm (0...
October 20, 2017: Chronobiology International
https://www.readbyqxmd.com/read/29039812/molecular-aspects-of-circadian-pharmacology-and-relevance-for-cancer-chronotherapy
#14
REVIEW
Narin Ozturk, Dilek Ozturk, Ibrahim Halil Kavakli, Alper Okyar
The circadian timing system (CTS) controls various biological functions in mammals including xenobiotic metabolism and detoxification, immune functions, cell cycle events, apoptosis and angiogenesis. Although the importance of the CTS is well known in the pharmacology of drugs, it is less appreciated at the clinical level. Genome-wide studies highlighted that the majority of drug target genes are controlled by CTS. This suggests that chronotherapeutic approaches should be taken for many drugs to enhance their effectiveness...
October 17, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28968417/effects-of-meal-composition-and-meal-timing-on-the-expression-of-genes-involved-in-hepatic-drug-metabolism-in-rats
#15
E M de Vries, J E Oosterman, H M Eggink, P de Goede, S Sen, E Foppen, O Boudzovitch-Surovtseva, A Boelen, J A Romijn, S E laFleur, A Kalsbeek
INTRODUCTION: With chronotherapy, drug administration is synchronized with daily rhythms in drug clearance and pharmacokinetics. Daily rhythms in gene expression are centrally mastered by the suprachiasmatic nucleus of the hypothalamus as well as by tissue clocks containing similar molecular mechanisms in peripheral organs. The central timing system is sensitive to changes in the external environment such as those of the light-dark cycle, meal timing and meal composition. We investigated how changes in diet composition and meal timing would affect the daily hepatic expression rhythms of the nuclear receptors PXR and CAR and of enzymes involved in P450 mediated drug metabolism, as such changes could have consequences for the practice of chronotherapy...
2017: PloS One
https://www.readbyqxmd.com/read/28950389/design-and-evaluation-of-chronomodulated-drug-delivery-of-tramadol-hydrochloride
#16
Thota Alekya, Dudhipala Narendar, Donthi Mahipal, Narala Arjun, Banala Nagaraj
Rheumatoid arthritis is an auto immune disease which requires chronotherapy as it occurs during early morning. Tramadol hydrochloride (TH) is an analgesic drug, used to treat rheumatoid arthritis. The aim of the present investigation was to develop chronomodulated drug delivery system of tramadol hydrochloride such that it releases the drug early in the morning, during which the symptoms of rheumatoid arthritis worsen. To develop chronomodulated drug delivery system of TH, initially core tablets of TH were prepared using three different supradisintegrants followed by coating with pH dependent polymer of Eudragit S100...
September 26, 2017: Drug Research
https://www.readbyqxmd.com/read/28928073/timing-of-food-intake-sounding-the-alarm-about-metabolic-impairments-a-systematic-review
#17
REVIEW
Guglielmo Beccuti, Chiara Monagheddu, Andrea Evangelista, Giovannino Ciccone, Fabio Broglio, Laura Soldati, Simona Bo
Growing evidence points to an association between timing of food intake and obesity in humans, raising the question if when to eat matters as much as what and how much to eat. Based on the new definition of obesity as a chronobiological disease, an unusual or late meal timing represent a circadian chronodisruption, leading to metabolic impairments. Preliminary data from cross-sectional and experimental studies suggest that changes in meal timing can influence obesity and success of weight loss therapy, independently from total energy intake, dietary composition and estimated energy expenditure...
November 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28865784/bedtime-chronotherapy-with-conventional-hypertension-medications-to-target-increased-asleep-blood-pressure-results-in-markedly-better-chronoprevention-of-cardiovascular-and-other-risks-than-customary-on-awakening-therapy
#18
REVIEW
Michael H Smolensky, Ramón C Hermida, Diana E Ayala, Artemio Mojón, José R Fernández
The bases for bedtime hypertension chronotherapy (BHCT) as superior chronoprevention against cardiovascular disease (CVD) are: (1) correlation between blood pressure (BP) and various risks is greater for ambulatory BP monitoring (ABPM) than office BP measurements (OBPM); (2) asleep BP mean is a better predictor of CVD risk than ABPM awake and 24-hour means and OBPM; and (3) targeting of asleep BP by BHCT with one or more conventional medications versus usual on-awakening therapy better reduces major and total CVD events...
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28865783/bedtime-blood-pressure-chronotherapy-significantly-improves-hypertension-management
#19
REVIEW
Ramón C Hermida, Diana E Ayala, José R Fernández, Artemio Mojón, Juan J Crespo, María T Ríos, Michael H Smolensky
Consistent evidence of numerous studies substantiates the asleep blood pressure (BP) mean derived from ambulatory BP monitoring (ABPM) is both an independent and a stronger predictor of cardiovascular disease (CVD) risk than are daytime clinic BP measurements or the ABPM-determined awake or 24-hour BP means. Hence, cost-effective adequate control of sleep-time BP is of marked clinical relevance. Ingestion time, according to circadian rhythms, of hypertension medications of 6 different classes and their combinations significantly improves BP control, particularly sleep-time BP, and reduces adverse effects...
October 2017: Heart Failure Clinics
https://www.readbyqxmd.com/read/28667474/development-and-in-vitro-in-vivo-characterization-of-chronomodulated-pulsatile-delivery-formulation-of-terbutaline-sulphate-by-box-behnken-statistical-design
#20
Prabhjot Singh Bajwa, Anurag Bhargava, Jaya Sharma, Shailesh Sharma, Abhimanyu Rai Sharma, Binu Sharma
In the present study, we have designed a press-coated pulsatile delivery tablet (PDT) of Terbutaline sulphate (TS) intended for prevention of early-morning asthma attacks. The formulation is capable of giving burst release of drug after 6 h of lag time. In this study, a press-coating technique was employed to coat a fast-release core tablet containing TS with a polymeric release retarding coat comprising of ethyl cellulose, HPMC K15M and Carbopol 971P. Fast-release core tablets were formulated using sodium starch glycolate with croscarmellose sodium (disintegrants)...
June 30, 2017: AAPS PharmSciTech
keyword
keyword
24769
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"