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Odontogenic cyst

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https://www.readbyqxmd.com/read/28521454/histopathological-and-immunohistochemical-study-in-keratocystic-odontogenic-tumors-predictive-factors-of-recurrence
#1
Tomofumi Naruse, Kentaro Yamashita, Souichi Yanamoto, Satoshi Rokutanda, Yuki Matsushita, Yuki Sakamoto, Hiroshi Sakamoto, Hisazumi Ikeda, Tohru Ikeda, Izumi Asahina, Masahiro Umeda
The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28512274/glucose-transporter-1-expression-in-odontogenic-keratocyst-dentigerous-cyst-and-ameloblastoma-an-immunohistochemical-study
#2
Alokenath Bandyopadhyay, Abikshyeet Panda, Shyam S Behura, Sujatha Ramachandra, Kailash C Dash, Pallavi Mishra
INTRODUCTION: An array of odontogenic lesions manifest in the maxillofacial region with variable presentations. The biological behavior of lesions, such as odontogenic keratocyst (OKC), dentigerous cyst (DC), and ameloblastoma (AM) always invite debate. Glucose transporter 1 (GLUT-1) is proven to be an indicator of metabolic behavior of several benign and malignant neoplasms. AIM: The purpose of this study was to evaluate the expression of GLUT-1 in OKC, DC, and AM to understand their metabolic behavior...
May 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/28499501/potential-involvement-of-chondroitin-sulfate-a-in-the-pathogenesis-of-ameloblastoma
#3
Xiangjun Li, Hiroshi Kurita, Tiepeng Xiao, Kyou Iijima, Kenji Kurashina, Jun Nakayama
Ameloblastoma is classified as a benign odontogenic tumor characterized by locally invasive behavior and high risk of recurrence. Here, we evaluate a potential role for glycosaminoglycan, a structural component of cell membranes and extracellular matrix, in ameloblstoma pathogenesis. We subjected formalin-fixed, paraffin-embedded tissue sections of 34 cases of ameloblastoma, 10 of odontogenic keratocyst, and 17 of dentigerous cyst to immunohistochemistry using monoclonal antibodies recognizing chondroitin sulfate A (CS-A), heparan sulfate (HS), and keratan sulfate (KS)...
May 9, 2017: Acta Histochemica
https://www.readbyqxmd.com/read/28489259/molecular-alterations-in-odontogenic-keratocysts-as-potential-therapeutic-targets
#4
REVIEW
Carolina Cavalieri Gomes, Letícia Martins Guimarães, Marina Gonçalves Diniz, Ricardo Santiago Gomez
The odontogenic keratocyst (OKC) is a cystic lesion, lined by uniformly-thickened parakeratinized epithelium. Some lesions are large and tend to recur after surgical treatment. The neoplastic nature of OKCs remains a matter of dispute. It is known that some sporadic OKCs harbor PTCH1 mutations, and via the dissection of cyst epithelium, these mutations were demonstrated to occur much more frequently than previously thought. In addition to the classical PTCH1 mutations, Hedgehog pathway disturbance and Bcl-2 protein overexpression, as detected via genome-wide expression analysis of OKCs, have been published...
May 10, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28489242/large-pediatric-maxillary-dentigerous-cysts-presenting-with-sinonasal-and-orbital-symptoms-a-case-series
#5
Shakil Ahmed Nagori, Anson Jose, Ongkila Bhutia, Ajoy Roychoudhury
Dentigerous cysts are benign odontogenic cysts associated with the crowns of unerupted, embedded, or impacted teeth. Most of them are associated with mandibular third molars, followed by maxillary third molars and canines. They are usually asymptomatic, and rarely do they grow extensively and compress the adjacent anatomic structures. We report 5 cases of extensive maxillary dentigerous cysts presenting with sinonasal and orbital symptoms. A literature review for similar presentations of dentigerous cysts has demonstrated 21 cases...
April 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28479716/primary-intraosseous-odontogenic-squamous-cell-carcinoma-of-the-mandible
#6
Paolo Cariati, Ana Belén Marin Fernandez, Miguel Perez de Perceval Tara, Jose Fernandez Solis, Ildefonso Martinez Lara
Primary intraosseous odontogenic squamous cell carcinoma (PIOSCC) is a rare tumor. The incidence is low, and approximately 200 cases are reported in literature. The etiology is associated with the malignant degeneration of embryological remains. Differential diagnosis includes alveolar carcinomas, jaw metastases from other locations, odontogenic tumors, and tumors of the maxillary sinus. However, the diagnosis could be delayed due to the absence of symptoms in early stages. Surgery represents the first choice treatment...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479706/disorganized-histomorphology-dentinogenic-ghost-cell-tumor
#7
Cheshta Walia, Bina Kashyap, Sudip Roy
Calcifying odontogenic cyst (COC) is a term used broadly to define lesions which were either cystic/solid in nature. However, a new term defining dentinogenic ghost cell tumor (DGCT), as its neoplastic counterpart, histopathologically showed the presence of dentinoid-like areas, ghost cells and ameloblastomatous-like odontogenic epithelium. This possesses a great challenge to an oral pathologist in diagnosing and differentiating it from solid multicystic ameloblastoma or COCs so as to ensure the biological behavior and pathogenesis behind its multifaceted nature...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479705/concurrent-central-odontogenic-fibroma-and-dentigerous-cyst-in-the-maxilla-a-rare-case-report
#8
Sanjay Murgod, H C Girish, J K Savita, V K Varsha
Central odontogenic fibroma (COF) represents a rare group of benign odontogenic tumor, while dentigerous cyst (DC), on the other hand, is the odontogenic cyst that encloses the crown of an unerupted tooth. A combination of COF and DC is rare and not reported in literature till date. The aim of this paper is to report a case of COF occurring concurrently with DC. The simultaneous occurrence of COF and DC raises the question of whether it is a collision tumor or their simultaneous occurrence is just a coincidence...
January 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28479048/digital-design-of-functional-surgery-for-odontogenic-cyst-intruding-into-maxillary-sinus
#9
Ying Kai Hu, Chi Yang, Guang Zhou Xu, Qian Yang Xie
INTRODUCTION: Traditional Caldwell-Luc approach needs modifications for odontogenic cysts intruding into the maxillary sinus, to preserve sinus mucosa and bony contour. Recently, digital technology has been widely applied to the field of maxillofacial surgery, guiding the surgical plan and improving its accuracy. OBJECTIVE: This study attempted to present and evaluate the functional surgery of odontogenic cysts intruding into the maxillary sinus using a computer-assisted pre-surgical design...
March 19, 2017: Brazilian Journal of Otorhinolaryngology
https://www.readbyqxmd.com/read/28476467/painful-trigeminal-neuropathy-attributed-to-a-space-occupying-lesion-presenting-as-a-toothache-a-report-of-4-cases
#10
Noboru Noma, Makoto Hayashi, Isao Kitahara, Andrew Young, Maasa Yamamoto, Kosuke Watanabe, Yoshiki Imamura
Painful trigeminal neuropathy attributed to a space-occupying lesion (code 13.1.2.5 in the International Classification of Headache Disorders, 3rd edition [beta version]) is an orofacial pain condition that has characteristics of classical trigeminal neuralgia but is caused by a space-occupying lesion. We present 4 cases of intracranial lesions mimicking odontogenic pain as follows: case 1, a 61-year-old woman presented with a chief complaint of aching soreness in the right mandibular molar area for 1 year; case 2, a 59-year-old man presented with severe pain in the left maxillary and mandibular molars; case 3, a 72-year-old man presented with a chief complaint of facial shock-like pain on the left side; and case 4, a 75-year-old man presented with a chief complaint of paroxysmal pain and numbness in the buccal gingiva of the right mandibular molar region...
May 2, 2017: Journal of Endodontics
https://www.readbyqxmd.com/read/28475084/emergent-gingival-cyst-of-the-adult
#11
John K Brooks, Justin W Kleinman, John R Basile
The gingival cyst of the adult is a relatively rare, benign odontogenic cyst that maintains an insidious growth rate. This article describes a case of a diminutive fibrotic overgrowth arising on the labial interproximal gingiva between the mandibular right canine and first premolar in a 68-year-old woman. Within 1 year, the lesion had increased in size and appeared vesicular. The morphologic changes warranted surgical excision and histopathologic review. The lesion was diagnosed as a gingival cyst. At a 4.5-month recall appointment, there was no evidence of recurrence...
May 2017: General Dentistry
https://www.readbyqxmd.com/read/28472562/prevalence-of-odontogenic-lesions-among-the-kanpur-population-an-institutional-study
#12
Amrita Raj, Gayathri Ramesh, Ramesh Nagarajappa, Amit Pandey, Ankita Raj
BACKGROUND: The frequency and incidence of odontogenic cysts and tumors are controversial and depends in the geographic location. These lesions have great clinical and histopathological diversity, and reflect a need for epidemiological profile to be considered when these lesions are studied. AIM: The purpose of this study was to determine the prevalence of odontogenic cysts and tumors over a period of 10 years and to compare with other data reported around the world...
May 2017: Journal of Experimental Therapeutics & Oncology
https://www.readbyqxmd.com/read/28469818/prevalence-and-distribution-of-odontogenic-cysts-in-a-mexican-sample-a-753-cases-study
#13
Luis Villasis-Sarmiento, Javier Portilla-Robertson, Arcelia Melendez-Ocampo, Luis-Alberto Gaitan-Cepeda, Elba-Rosa Leyva-Huerta
BACKGROUND: Odontogenic cysts (OC) are the most frequent lesions of the jaws and their constant epidemiological update is necessary and indispensable. Therefore the principal objective of this report was To determine prevalence and clinical-demographical characteristics of OC in a Mexican sample. MATERIAL AND METHODS: 753 cases of OC coming from the archive of a head and neck histopathological teaching service, from January 2000 to December 2013, were included. OC cases were re-assessed according 2005 WHO classification...
April 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/28460843/interest-of-decompression-in-orthodontics-case-report-of-a-keratocyst-during-childhood
#14
Alexandre Alpy, Laurianne Tournaire, Fréderic Vaysse, Christine Marchal-Sixou, Arnaud Lhomme, Bruno Courtois
Keratocysts, also known as keratocystic odontogenic tumors (KCOT), make up 7% of all odontogenic cysts and develop asymptomatically in most cases. Enucleation is the benchmark treatment. However, there are surgical alternatives. Marsupialization and decompression are necessary in some cases, mainly when the KCOT is large, thus causing an increased risk of bone fracture, or if it has engulfed important elements such as the inferior alveolar nerve or teeth, consequently causing alveolar bone growth failure. The authors describe the case of a nine-year-old child treated for a large keratocyst situated in sector 4 (lower right jaw), impacting both premolars and the canine (45, 44 and 43)...
April 28, 2017: International Orthodontics
https://www.readbyqxmd.com/read/28449413/sporadic-versus-syndromic-keratocysts-can-we-predict-treatment-outcome-a-review-of-102-cysts
#15
Dani Noy, Adi Rachmiel, Keidar Zar, Omri Emodi, Rafael M Nagler
OBJECTIVES: Keratocystic odontogenic tumor (KCOT) demonstrates variable growth mechanisms and biologic behavior, partly due to origin and histology. We looked for the most contributing factors in predicting outcome of treatment. SUBJECTS AND METHODS: We retrospectively reviewed 118 medical files of patients diagnosed with KCOT (by tissue biopsy before surgical treatment) with/without nevoid basal cell carcinoma syndrome (NBCCS) from 1995 to 2015. Data were recorded and analyzed statistically to determine the treatment-outcome correlation...
April 27, 2017: Oral Diseases
https://www.readbyqxmd.com/read/28409045/odontogenic-cyst-with-verrucous-proliferation-exhibiting-melanin-pigmentation
#16
Nidhi Manaktala, Karen Boaz, Krupa Mehta Soni, Srikant Natarajan, Junaid Ahmed, Keshava Bhat, Nandita Kottieth Pallam, Amitha Juanita Lewis
Verrucous proliferation arising from odontogenic cysts is a rare entity. We report an unusual case of an infected odontogenic cyst with verrucous proliferation and melanin pigmentation in a 13-year-old male patient who presented with an intraoral swelling in relation to impacted teeth 26 and 27. The enucleated lesion was diagnosed as an odontogenic keratocyst and the patient died within two years of presentation due to multiple recurrences. The clinical, radiological, and microscopic features of the lesion are presented with an attempt to discuss the etiopathogenesis...
2017: Case Reports in Pathology
https://www.readbyqxmd.com/read/28390759/tube-decompression-for-staged-treatment-of-a-calcifying-odontogenic-cyst-a-case-report
#17
Hany A Emam, Judson Smith, Ashleigh Briody, Courtney A Jatana
The calcifying odontogenic cyst is a rare developmental odontogenic lesion with a distinguishing cystic lining containing "ghost" epithelial cells. The variation in clinical, radiographic, and histologic findings makes the treatment decision difficult for these lesions. There are very few reports on treatment, with enucleation and curettage being the standard surgical method of choice for the cystic type and excision of the tumor for the solid type. A 2-stage surgical approach consisting of initial decompression with tube placement followed by a secondary procedure of enucleation and curettage is common for other large odontogenic cysts, such as dentigerous and odontogenic keratocysts...
March 18, 2017: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/28388515/long-term-observation-of-a-large-keratocystic-odontogenic-tumour-of-the-mandible-treated-by-a-single-enucleation-procedure-a-case-report-and-literature-review
#18
Tobias L Pittl, Marius Meier, Paul Hakl, Walter Sutter, Dritan Turhani
INTRODUCTION: Keratocystic odontogenic tumours (KCOTs) are benign lesions of the jaw that are characterised by expansive growth and high rates of recurrence. Herein, we present a novel minimally invasive method for the surgical treatment of KCOTs. CASE PRESENTATION: We present a 49-year-old woman with a rare, large KCOT of the mandible extending from tooth 37 to tooth 47. A single enucleation procedure was selected as the surgical technique combined with a titanium plate...
2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28387190/a-rare-case-of-gingival-cyst-in-a-child
#19
Jennifer C Park, Wa Sham Cheung, Karen M Campbell
Gingival cysts, which are more frequently reported as gingival cysts of adults (GCA), are soft tissue cystic lesions of odontogenic origin that are infrequently seen, especially in children. These lesions usually appear as localized firm elevations on the facial gingiva in the anterior segment of the mandible. The purpose of this paper is to present a rare case of a gingival cyst discovered on the palatal aspect of the posterior maxilla in a four-year-old child. The lesion was treated with excisional biopsy...
January 15, 2017: Journal of Dentistry for Children
https://www.readbyqxmd.com/read/28377093/decompression-of-keratocystic-odontogenic-tumors-leading-to-increased-fibrosis-but-without-any-change-in-epithelial-proliferation
#20
Sarah Awni, Brendan Conn
OBJECTIVE: The aim of this study was to investigate whether decompression treatment induces changes in the histology or biologic behavior of keratocystic odontogenic tumor (KCOT). STUDY DESIGN: Seventeen patients with KCOT underwent decompression treatment with or without enucleation. Histologic evaluation and immunohistochemical expression of p53, Ki-67, and Bcl-2 were analyzed by using conventional microscopy. RESULTS: KCOT showed significantly increased fibrosis (P = ...
December 30, 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
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