keyword
https://read.qxmd.com/read/38537201/prospective-evaluation-of-serum-free-thiols-in-inflammatory-bowel-disease-a-candidate-to-replace-c-reactive-protein-for-disease-activity-assessment
#21
JOURNAL ARTICLE
Anuj Bohra, Nicholas Batt, Krishneel Dutt, Pavel Sluka, Olga Niewiadomski, Abhinav Vasudevan, Daniel R Van Langenberg
BACKGROUND: Serum free thiols (SFTs) reflecting oxidative stress appear to correlate with inflammatory bowel disease (IBD) activity. We aimed to evaluate the performance of SFTs concentrations vs endoscopic and histological activity, compare SFTs with established biomarkers, and identify clinical and laboratory parameters independently associated with SFT levels in IBD patients. METHODS: Patients with confirmed IBD undergoing routine ileocolonoscopy for activity assessment were prospectively recruited, with serum samples obtained concurrently for SFTs and routine bloods, plus fecal calprotectin and immunochemical tests were collected ±30 days from ileocolonoscopy...
March 27, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38536626/construct-validity-of-eq-5d-5l-among-patients-with-inflammatory-bowel-disease-a-study-based-on-real-world-data-from-the-swedish-inflammatory-bowel-disease-registry
#22
JOURNAL ARTICLE
Jack Latteur, Olivia Ernstsson, Evalill Nilsson, Susanna Jäghult, Emelie Heintz
OBJECTIVES: The Swedish Inflammatory Bowel Disease Registry (SWIBREG) includes approximately 84% of all patients with inflammatory bowel disease (IBD) treated with immunomodulators, biologics or surgery in Sweden. Data on health-related quality of life (HRQoL) have been collected using EQ-5D-5L in the registry since 2012. Nevertheless, there are few studies assessing the validity of EQ-5D-5L in this patient population. Thus, the aim of this study was to assess the construct validity of EQ-5D-5L amongst patients with IBD (ulcerative colitis and Crohn's disease)...
March 27, 2024: Journal of Patient-Reported Outcomes
https://read.qxmd.com/read/38536561/exploring-the-causal-relationship-between-takayasu-arteritis-and-inflammatory-bowel-disease-using-mendelian-randomization
#23
JOURNAL ARTICLE
Xiaoli Pang, Huizhong Yang, Chi Wang, Suyan Tian
Takayasu arteritis (TA) and inflammatory bowel disease (IBD) are two distinct diseases; however, previous studies have reported many cases of IBD-TA coexistence. Additionally, the incidence of IBD in patients with TA is estimated to be significantly higher than the incidence in the general population. Therefore, the two diseases are anticipated to be linked. Mendelian randomization (MR) analysis assesses whether an exposure might causally affect an outcome by using genetic variants inherited randomly at conception, thereby reducing the impact of confounding and reverse causality...
March 27, 2024: Immunologic Research
https://read.qxmd.com/read/38534702/-helicobacter-pylori-in-inflammatory-bowel-diseases-active-protagonist-or-innocent-bystander
#24
REVIEW
Elisabetta Bretto, Simone Frara, Angelo Armandi, Gian Paolo Caviglia, Giorgio Maria Saracco, Elisabetta Bugianesi, Demis Pitoni, Davide Giuseppe Ribaldone
Helicobacter pylori ( H. pylori ) infection is a prominent entity within human infectious diseases which cause chronic gastritis, peptic ulcers, gastric malignancies, and extragastric disorders. Its persistent colonization can lead to a systemic inflammatory cascade, potentially instigating autoimmune responses and contributing to the pathogenesis of autoimmune diseases. While the specific etiopathogenesis of inflammatory bowel diseases (IBDs) is still unknown, it is widely recognized that immunological, genetic, and environmental factors are implicated...
March 17, 2024: Antibiotics
https://read.qxmd.com/read/38534360/the-roles-of-fibrinolytic-factors-in-bone-destruction-caused-by-inflammation
#25
REVIEW
Yosuke Kanno
Chronic inflammatory diseases, such as rheumatoid arthritis, spondyloarthritis, systemic lupus erythematosus, Crohn's disease, periodontitis, and carcinoma metastasis frequently result in bone destruction. Pro-inflammatory cytokines such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, and IL-17 are known to influence bone loss by promoting the differentiation and activation of osteoclasts. Fibrinolytic factors, such as plasminogen (Plg), plasmin, urokinase-type plasminogen activator (uPA), its receptor (uPAR), tissue-type plasminogen activator (tPA), α2-antiplasmin (α2AP), and plasminogen activator inhibitor-1 (PAI-1) are expressed in osteoclasts and osteoblasts and are considered essential in maintaining bone homeostasis by regulating the functions of both osteoclasts and osteoblasts...
March 15, 2024: Cells
https://read.qxmd.com/read/38533919/accurate-robust-and-scalable-machine-abstraction-of-mayo-endoscopic-subscores-from-colonoscopy-reports
#26
JOURNAL ARTICLE
Anna L Silverman, Balu Bhasuran, Arman Mosenia, Fatema Yasini, Gokul Ramasamy, Imon Banerjee, Saransh Gupta, Taline Mardirossian, Rohan Narain, Justin Sewell, Atul J Butte, Vivek A Rudrapatna
BACKGROUND: The Mayo endoscopic subscore (MES) is an important quantitative measure of disease activity in ulcerative colitis. Colonoscopy reports in routine clinical care usually characterize ulcerative colitis disease activity using free text description, limiting their utility for clinical research and quality improvement. We sought to develop algorithms to classify colonoscopy reports according to their MES. METHODS: We annotated 500 colonoscopy reports from 2 health systems...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38532703/transplant-of-microbiota-from-crohn-s-disease-patients-to-germ-free-mice-results-in-colitis
#27
JOURNAL ARTICLE
Irshad Ali Sheikh, Jared Bianchi-Smak, Daniel Laubitz, Gabriele Schiro, Monica T Midura-Kiela, David G Besselsen, Gayatri Vedantam, Sara Jarmakiewicz, Rafał Filip, Fayez K Ghishan, Nan Gao, Pawel R Kiela
Although the role of the intestinal microbiota in the pathogenesis of inflammatory bowel disease (IBD) is beyond debate, attempts to verify the causative role of IBD-associated dysbiosis have been limited to reports of promoting the disease in genetically susceptible mice or in chemically induced colitis. We aimed to further test the host response to fecal microbiome transplantation (FMT) from Crohn's disease patients on mucosal homeostasis in ex-germ-free (xGF) mice. We characterized and transferred fecal microbiota from healthy patients and patients with defined Crohn's ileocolitis (CD_L3) to germ-free mice and analyzed the resulting microbial and mucosal homeostasis by 16S profiling, shotgun metagenomics, histology, immunofluorescence (IF) and RNAseq analysis...
2024: Gut Microbes
https://read.qxmd.com/read/38531883/polygenic-risk-score-for-ulcerative-colitis-predicts-immune-checkpoint-inhibitor-mediated-colitis
#28
JOURNAL ARTICLE
Pooja Middha, Rohit Thummalapalli, Michael J Betti, Lydia Yao, Zoe Quandt, Karmugi Balaratnam, Cosmin A Bejan, Eduardo Cardenas, Christina J Falcon, David M Faleck, Matthew A Gubens, Scott Huntsman, Douglas B Johnson, Linda Kachuri, Khaleeq Khan, Min Li, Christine M Lovly, Megan H Murray, Devalben Patel, Kristin Werking, Yaomin Xu, Luna Jia Zhan, Justin M Balko, Geoffrey Liu, Melinda C Aldrich, Adam J Schoenfeld, Elad Ziv
Immune checkpoint inhibitor-mediated colitis (IMC) is a common adverse event of treatment with immune checkpoint inhibitors (ICI). We hypothesize that genetic susceptibility to Crohn's disease (CD) and ulcerative colitis (UC) predisposes to IMC. In this study, we first develop a polygenic risk scores for CD (PRSCD ) and UC (PRSUC ) in cancer-free individuals and then test these PRSs on IMC in a cohort of 1316 patients with ICI-treated non-small cell lung cancer and perform a replication in 873 ICI-treated pan-cancer patients...
March 26, 2024: Nature Communications
https://read.qxmd.com/read/38531570/precise-infliximab-exposure-and-pharmacodynamic-control-to-achieve-deep-remission-in-paediatric-crohn-s-disease-remodel-cd-study-protocol-for-a-multicentre-open-label-pragmatic-clinical-trial-in-the-usa
#29
JOURNAL ARTICLE
Phillip Paul Minar, Ruben J Colman, Nanhua Zhang, Tomoyuki Mizuno, Alexander A Vinks
INTRODUCTION: The only biologic therapy currently approved to treat moderate to severe Crohn's disease in children (<18 years old) are those that antagonise tumour necrosis factor-alpha (anti-TNF). Therefore, it is critically important to develop novel strategies that maximise treatment effectiveness in this population. There is growing evidence that rates of sustained corticosteroid-free clinical remission, endoscopic healing and drug durability considerably improve when patients receive early anti-TNF dose optimisations guided by reactive or proactive therapeutic drug monitoring and pharmacodynamic monitoring...
March 25, 2024: BMJ Open
https://read.qxmd.com/read/38531553/simultaneous-presentation-of-takayasu-arteritis-and-crohn-s-disease-in-a-middle-aged-patient-are-they-two-sides-of-the-same-coin
#30
JOURNAL ARTICLE
Swathi Suyamburajan, Rama Bhat, Raghavendra Rao, Srilatha Srilatha Parampalli
Autoimmune disorders have a wide spectrum of symptoms, often with multiorgan involvement. Multiple autoimmune disorders also often occur concurrently in the same patient. These two possibilities must be distinguished in patients with multiorgan involvement to ensure early diagnosis and treatment. Here, we report a case of a previously healthy man who presented with simultaneous Takayasu arteritis and Crohn's disease. He presented with heart failure with reduced ejection fraction and severe aortic regurgitation...
March 26, 2024: BMJ Case Reports
https://read.qxmd.com/read/38531068/real-world-effectiveness-of-ustekinumab-in-ulcerative-colitis-in-a-united-states-multicenter-cohort-consortium
#31
JOURNAL ARTICLE
Andres J Yarur, Ryan Ungaro, Katherine Huang, Wenfei Wang, Priya Sasankan, Mir Zulqarnain, Amanda M Johnson, Geoffrey Bader, Carl Kay, Nicholas Costable, David Dulaney, Marc Fenster, Poonam Beniwal-Patel, Gaurav Syal, Anish Patel, Edward Loftus, Joel Pekow, Benjamin Cohen, Parakkal Deepak
BACKGROUND: Pivotal trials have shown that ustekinumab is effective in ulcerative colitis (UC). However, the population included in these trials do not represent the cohort of patients treated in the real world. In this study, we aimed to describe the effectiveness and safety of ustekinumab in a clinical cohort of patients with UC. METHODS: We performed a multicenter retrospective cohort study and included patients with active UC starting ustekinumab. Variables collected included demographics, clinical data, and disease activity (measured using partial Mayo score [PMS] and endoscopic Mayo score) at follow-up...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38530319/serum-fibroblast-growth-factor-19-level-correlates-inversely-with-clinical-and-endoscopic-activity-of-inflammatory-bowel-disease
#32
JOURNAL ARTICLE
Agata Łukawska, Agata Mulak
BACKGROUND: Inflammatory bowel disease (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a chronic condition with relapsing-remitting course. Diarrhea and abdominal pain are the most common IBD symptoms. Fibroblast growth factor 19 (FGF19) is an endocrine factor that inhibits hepatic bile acid production and may be used as a diagnostic marker for bile acid malabsorption. OBJECTIVES: To assess serum FGF19 levels in active and inactive phases of IBD and find a potential correlation between FGF19 and disease activity...
March 26, 2024: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
https://read.qxmd.com/read/38530169/rapid-onset-of-intestinal-lymphoma-in-crohn-disease
#33
JOURNAL ARTICLE
Xin-Yue Wang, Xue-Hua Li
No abstract text is available yet for this article.
March 2024: Radiology
https://read.qxmd.com/read/38529957/pan-enteric-capsule-endoscopy-to-characterize-crohn-s-disease-phenotypes-and-predict-clinical-outcomes-in-children-and-adults-the-bomiro-study
#34
JOURNAL ARTICLE
Salvatore Oliva, Silvio Veraldi, Giusy Russo, Marina Aloi, Fernando Rizzello, Paolo Gionchetti, Patrizia Alvisi, Flavio Labriola, Maurizio Vecchi, Pini Eidler, Luca Elli, Nikolas Dussias, Gian Eugenio Tontini, Carlo Calabrese
BACKGROUND: Pan-enteric capsule endoscopy (PCE) provides useful information for the management of Crohn's disease (CD), especially in children. No study has evaluated the ability of PCE to characterize CD phenotypes and outcomes in children and adults. METHODS: In a prospective multicenter observational study, we recruited patients with CD >6 years from 4 centers in Italy. Patients underwent clinical, biomarker assessment and PCE. Lesions were graded using the PCE system...
March 26, 2024: Inflammatory Bowel Diseases
https://read.qxmd.com/read/38529201/the-role-of-inflammatory-biomarkers-in-mediating-the-effect-of-inflammatory-bowel-disease-on-nonmalignant-digestive-system-diseases-a-multivariable-mendelian-randomized-study
#35
JOURNAL ARTICLE
Shu Zhou, Qi Sun, Ning Gao, Zekai Hu, Junjun Jia, Jiangwei Song, Guocong Xu, Aiqiang Dong, Weiliang Xia, Jiafeng Wu
BACKGROUND: While observation studies have shown a positive correlation between inflammatory bowel disease (IBD) and the risk of nonmalignant digestive system diseases, a definitive causal relationship has not yet been clearly established. METHODS: Mendelian randomization (MR) was employed to investigate the potential causal association between genetic susceptibility to IBD and nonmalignant gastrointestinal diseases. Genetic variants were extracted as instrumental variables (IVs) from a genome-wide association study (GWAS) meta-analysis, which included 12,194 cases of Crohn's disease (CD) and 28,072 control cases of European ancestry...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38528940/risk-of-primary-gastrointestinal-lymphoma-in-patients-with-inflammatory-conditions-exposed-to-tumor-necrosis-factor-alpha-inhibitors-and-immunomodulators-a-case-control-study
#36
JOURNAL ARTICLE
Manuel B Braga-Neto, Jason Nasser, Xiao Xing Iris Wang, William Scott Harmsen, Laura E Raffals, Michael Camilleri, Victor Chedid
INTRODUCTION: The aim of this case-control study was to determine if exposure to tumor necrosis factor alpha inhibitors (TNFIs) or immunomodulators (thiopurines or methotrexate) was associated with development of primary gastrointestinal lymphoma (PGIL) in patients with chronic inflammatory conditions. METHODS: Patients with PGIL and controls evaluated at a tertiary care center over 20 years were matched 1:3 using a medical record informatics search engine based on their chronic inflammatory condition (Crohn's disease [CD], ulcerative colitis [UC], rheumatoid arthritis, ankylosing spondylitis, and psoriatic arthritis) and duration of follow-up...
January 2024: Crohn's & colitis 360
https://read.qxmd.com/read/38528835/coincidence-of-antibodies-against-hwp1-and-asca-two-distinct-molecular-targets-of-candida-albicans-reinforces-the-link-between-this-fungal-species-and-coeliac-disease
#37
JOURNAL ARTICLE
Boualem Sendid, Christopher Cao, Jean-Frederic Colombel, Daniel Poulain
Candida albicans is an immunogen for anti- Saccharomyces cerevisiae antibodies (ASCA), a serological marker of Crohn's disease. ASCA has also been reported in other autoimmune diseases, including coeliac disease (CeD). A strong antibody response against Hwp1, a protein associated with invasive hyphal form of C. albicans which presents peptide sequence homologies with gliadin, has also been described in CeD. This observation supports the hypothesis that C. albicans hyphal transition in C. albicans may trigger CeD onset through a mechanism of molecular/antigenic mimicry...
December 2024: Virulence
https://read.qxmd.com/read/38528540/association-between-inflammatory-bowel-disease-and-cancer-risk-evidence-triangulation-from-genetic-correlation-mendelian-randomization-and-colocalization-analyses-across-east-asian-and-european-populations
#38
JOURNAL ARTICLE
Di Liu, Meiling Cao, Haotian Wang, Weijie Cao, Chenguang Zheng, Yun Li, Youxin Wang
BACKGROUND: Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis (UC), has been associated with several cancer risks in observational studies, but the observed associations have been inconsistent and may face the bias of confounding and reverse causality. The potential causal relationships between IBD and the risk of cancers remain largely unclear. METHODS: We performed genome-wide linkage disequilibrium score regression (LDSC), standard two-sample Mendelian randomization (MR), and colocalization analyses using summary genome-wide association study (GWAS) data across East Asian and European populations to evaluate the causal relationships between IBD and cancers...
March 25, 2024: BMC Medicine
https://read.qxmd.com/read/38526938/savings-in-social-expenditures-for-work-incapacity-in-patients-with-inflammatory-bowel-disease-depend-on-access-to-innovative-therapies-in-poland
#39
JOURNAL ARTICLE
Edyta Zagórowicz, Grzegorz Binowski, Dominik Strządała, Cezary Pruszko, Piotr Kucha, Jarosław Reguła
OBJECTIVES: Inflammatory bowel diseases (IBD) are an increasing burden for societies. We examined Polish Social Insurance Institution (ZUS) work incapacity expenditures for people with IBD compared with the general population. METHODS: Aggregate data were obtained on ZUS expenditures between 2012 and 2021 in Polish zlotys (PLN). Annual work incapacity benefit expenditures were analyzed and IBD benefit expenditures were examined relative to innovative IBD drug utilization in individual provinces...
March 19, 2024: European Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38526534/correlation-of-socioeconomic-and-environmental-factors-with-incidence-of-crohn-disease-in-children-and-adolescents-systematic-review-and-meta-regression
#40
REVIEW
Jens Weidner, Ingmar Glauche, Ulf Manuwald, Ivana Kern, Ines Reinecke, Franziska Bathelt, Makan Amin, Fan Dong, Ulrike Rothe, Joachim Kugler
BACKGROUND: The worldwide incidence of Crohn disease (CD) in childhood and adolescence has an increasing trend, with significant differences between different geographic regions and individual countries. This includes an increase in the incidence of CD in countries and geographic regions where CD was not previously prevalent. In response to the increasing incidence, the pediatric care landscape is facing growing challenges. OBJECTIVE: This systematic review and meta-analysis were undertaken to comprehensively delineate the incidence rates of CD in pediatric populations across different countries and to explore potential influencing factors...
March 25, 2024: JMIR Public Health and Surveillance
keyword
keyword
2476
2
3
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.