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Odontogenic tumor

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https://www.readbyqxmd.com/read/28060370/diagnosing-the-most-common-odontogenic-cystic-and-osseous-lesions-of-the-jaws-for-the-practicing-pathologist
#1
Robert A Robinson
Odontogenic cysts and osseous lesions are often seen as challenging diagnostic lesions but the majority of them are easily classified. This article outlines the diagnostic features required for separating the most common of odontogenic cysts and select osseous lesions of the jaws. Clinical and radiographic findings of these jaw lesions often lead to a differential diagnosis that only the histologic findings will clarify. Dentigerous cyst, keratocystic odontogenic tumor, and certain ameloblastomas that have cystic change, may have identical radiographic findings, with only separation by their specific histologic features leading to the significantly different treatments required for each...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28054463/kallikrein-related-peptidase-expression-in-odontogenic-cysts-and-tumors-an-immunohistochemical-comparative-study
#2
Mark Roger Darling, Rebecca Woodford, Karl Kevin Cuddy, Linda Jackson-Boeters, Alyssa Hayter, Jeyanth Inkaran, Eleftherios P Diamandis, Zia Khan
AIM: The aim of the present study was to profile the expression of human kallikrein (KLK)-related peptidases (KLK) in odontogenic lesions. METHODS: Paraffin-embedded, formalin-fixed, non-odontogenic (control) and odontogenic lesions were stained for KLK using a standard immunohistochemical technique. The intensity and proportion of epithelial cells stained was scored. Reverse transcription-polymerase chain reaction was utilized to evaluate KLK 1-15 mRNA expression in ameloblastomas...
January 4, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28052640/retrospective-analysis-of-benign-orofacial-tumors-at-a-tertiary-referral-center-in-saudi-arabia
#3
Nandimandalam Venkata Vani, Ali M Idris, Sanaa M Saleh, Faisal M Tubaigy, Fahd A Alharbi, Abubakr A Sharwani, Nabil Tadrus, Saman Warnakulasuriya
AIM: The aim of the present study was to analyze the prevalence of benign tumors of the orofacial region at a tertiary referral center in the south-western region of Saudi Arabia. METHODS: Cases from 2009 to 2014 were retrieved from October 2014 to June 2015 from the archives of the histopathology department of the center. Demographic and clinical details of the patients were recorded. RESULTS: Of the 714 oral and maxillofacial biopsy specimens, 78 (10...
January 4, 2017: Journal of Investigative and Clinical Dentistry
https://www.readbyqxmd.com/read/28038480/intracranial-ameloblastoma-arising-from-the-maxilla-an-interdisciplinary-surgical-approach
#4
Johanna Quick-Weller, Felix Koch, Nazife Dinc, Stephanie Lescher, Peter Baumgarten, Patrick Harter, Friedrich Scheerer, Robert Sader, Volker Seifert, Gerhard Marquardt, Thomas Freiman
Background Ameloblastomas are a rare tumor entity accounting for only 10% of all odontogenic tumors. They mostly originate from the mandible. Only a few cases are known to grow aggressively and to invade the orbit, nasal cavity, or even the brain. Patient and Methods/Case Report We present the case of a 57-year-old patient who was admitted with a huge tumor involving the nasal cavity, the left maxilla, and the anterior fossa. Histologic diagnosis was made by biopsy. A combined two-stage neurosurgical maxillofacial approach was planned...
December 30, 2016: Journal of Neurological Surgery. Part A, Central European Neurosurgery
https://www.readbyqxmd.com/read/28025437/diverse-calcification-patterns-of-ameloblastic-fibro-odontoma-on-radiographic-examination
#5
Masao Araki, Shunsuke Namaki, Toshihiko Amemiya, Kunihito Matsumoto, Kazuya Honda, Yoshiyuki Yonehara, Naoyuki Matsumoto, Masatake Asano
The occurrence of ameloblastic fibro-odontoma (AFO) in the oral region is unusual and accounts for 1-3% of all odontogenic tumors. AFO presents mixed radiopaque patterns within the lesion with diverse findings; therefore, it is important to compare this tumor with other odontogenic tumors that radiographically present with calcified bodies. Herein, we observed the calcification patterns within the lesion in seven AFO cases (five males, two females; mean age, 8.3 years; age range, 4-13 years). Periapical and panoramic radiographs were obtained from all seven cases...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28025428/expression-of-p73-and-trail-in-odontogenic-cysts-and-tumors
#6
Marco Mascitti, Andrea Santarelli, Antonio Zizzi, Maurizio Procaccini, Lorenzo Lo Muzio, Corrado Rubini
Odontogenic tumors are a group of lesions arising from the odontogenic apparatus. Although the mechanism of oncogenesis and tumor progression in these lesions remains unknown, certain proteins, such as those involved in apoptosis, seem to be involved in the differentiation and proliferation of odontogenic epithelial cells. The aim of this study was to analyze the expression of p73 and TNF-related apoptosis-inducing ligand (TRAIL) in odontogenic tumors and cysts, and to clarify changes in the expression of these proteins...
2016: Journal of Oral Science
https://www.readbyqxmd.com/read/28011178/recurrence-probability-for-keratocystic-odontogenic-tumors-an-analysis-of-6427-cases
#7
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: To investigate and compare the probability of recurrence of keratocystic odontogenic tumors (KCOTs) for different variables and treatment protocols. MATERIALS AND METHODS: An electronic search was undertaken in April 2016 that included clinical series of KCOTs reporting recurrences. Untransformed proportions and meta-analyses were performed to estimate the probability/risk of recurrence, according to several variables. RESULTS: A total of 94 publications were included (6427 KCOTs, 1464 recurrences)...
November 19, 2016: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28007509/keratoameloblastoma-of-the-mandible
#8
S Anajar, A Lakhbal, R Abada, M Mahtar
INTRODUCTION: Keratoameloblastoma is an extremely rare odontogenic tumor, as only 18 cases have been reported in the literature. CASE REPORT: The authors report a case of keratoameloblastoma in a 32-year-old woman and review the literature concerning the clinical features, radiological appearance, histopathological findings and treatment options. DISCUSSION: Keratoameloblastoma is a rare tumor observed more frequently in males (sex ratio: 3:1) characterized by extensive keratin production in odontogenic islets and fibrous stroma...
December 19, 2016: European Annals of Otorhinolaryngology, Head and Neck Diseases
https://www.readbyqxmd.com/read/27995335/differential-expression-of-the-epithelial-mesenchymal-transition-factors-snail-slug-twist-tgf-%C3%AE-and-e-cadherin-in-ameloblastoma
#9
Kagami Kurioka, Masahiro Wato, Tomio Iseki, Akio Tanaka, Shosuke Morita
Epithelial mesenchymal transition (EMT), the transition of epithelial cells into motile mesenchymal cells, plays an important role in embryogenesis, cancer invasion, and metastasis. Ameloblastomas are common epithelial odontogenic tumors, occurring exclusively in the mandible with locally invasive growth. Thirty-seven ameloblastoma cases were evaluated for the involvement of EMT by immunohistochemical staining and western blotting using antibodies against Slug, Snail, Twist, TGF-β, and E-cadherin. Double immunostaining was also performed...
December 19, 2016: Medical Molecular Morphology
https://www.readbyqxmd.com/read/27957261/p53-p63-and-p73-expression-and-angiogenesis-in-keratocystic-odontogenic-tumors
#10
Soranun Chandrangsu, Kraisorn Sappayatosok
BACKGROUND: Keratocystic odontogenic tumors (KCOTSs) are odontogenic tumors previously referred to as odontogenic keratocysts. Several studies have reported that KCOT behavior is more like that of a benign neoplasm than a cyst. KCOTs are locally destructive and exhibit a high recurrence rate. The objective of this study is to characterize the expression of p53, p63 and p73 in KCOTs together with the relationship between their expression and KCOT angiogenesis and recurrence. MATERIAL AND METHODS: Standard indirect immunohistochemistry using monoclonal antibodies specific to human p53, p63, p73 and CD105 was performed in formalin-fixed paraffin-embedded tissue sections of 39 KCOT samples...
December 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/27955959/what-surgical-treatment-has-the-lowest-recurrence-rate-following-the-management-of-keratocystic-odontogenic-tumor-a-large-systematic-review-and-meta-analysis
#11
Essam Ahmed Al-Moraissi, Ayed Ali Dahan, Mohamed Salah Alwadeai, Fadekemi Olufunmilayo Oginni, Jamil Mohammed Al-Jamali, Ahmed Saleh Alkhutari, Nashwan Hamid Al-Tairi, Abdulrazaq Ahmed Almaweri, Jaber Saleh Al-Sanabani
PURPOSE: Among the different surgical treatments for keratocystic odontogenic tumors (KOTs), there is no single method associated with a zero recurrence rate (RR). Thus, this study aimed to seek the best surgical treatment with the least RR using a weighted event rated meta-analysis. MATERIALS AND METHODS: To address our study purpose, a systematic review and meta-analysis based on the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline was performed...
January 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/27942555/extrafollicular-adenomatoid-odontogenic-tumor-an-unusual-case-presentation
#12
Vinay Kumar Reddy Kundoor, Kotya Naik Maloth, Nagu Naik Guguloth, Sunitha Kesidi
Adenomatoid odontogenic tumor (AOT) is an uncommon tumor of odontogenic origin and often misdiagnosed as an odontogenic cyst. It is predominantly found in young female patients, located more often in maxilla, and in most cases associated with an unerupted permanent tooth. There are three variants of AOT namely follicular, extra follicular, and peripheral. We report an unusual case of extrafollicular AOT in maxilla of a 50-year old male patient.
December 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27942554/peripheral-ameloblastic-fibroma-report-of-a-rare-case
#13
Mahsa Kalantari, Sahand Samieirad, Parisa Kalantari
Ameloblastic fibroma is a rare mixed odontogenic tumor mostly occurring in the posterior region of the mandible. The peripheral variant is very rare and to the best of our knowledge, only three cases have been reported in the English literature. In this report, we describe a case of peripheral ameloblastic fibroma in a 54-year-old woman with two years of follow-up.
December 2016: Journal of Dentistry
https://www.readbyqxmd.com/read/27941562/clear-cell-variant-of-calcifying-epithelial-odontogenic-tumor-a-case-report-and-preliminary-immunohistochemical-study-of-the-shh-pathway
#14
Braúlio C Júnior, Vinicius R V M Muniz, Manuela T A Vidal, Clarissa A Gurgel, Jorge E Leon, Roberto A De Azevedo, Iêda C Rebello, Jean N Dos Santos
No abstract text is available yet for this article.
December 9, 2016: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/27936914/characteristic-features-of-odontogenic-myxoma-on-cone-beam-computed-tomography
#15
Kaili Wang, Wenhao Guo, Meng You, Li Liu, Bei Tang, Guangning Zheng
OBJECTIVES: To illustrate characteristic features of odontogenic myxoma (OM) on CBCT. METHODS: From fifty-two subjects with histopathologically diagnosed odontogenic myxomas, eighteen that underwent CBCT examination were retrieved between May 2009 and April 2016. Features on CBCT images and clinical records were carefully observed and analyzed. RESULTS: Characteristic features include: (1) Fine and straight septa were recognized to separate the tumor into triangular, square or rectangular spaces which appeared as "tennis racket" or "honeycomb" patterns; (2) Septa frequently scattered to the borders of lesions and appeared perpendicular to the margins; (3) Tooth displacement and resorption were seen in most of OM lesions; (4) OMs were noted to have a tendency to involve the alveolar process, scalloped between the roots, and affected the integrity of the alveolar ridge; (5) The cortex of OMs appeared normally perforated and the edge of the cortex expanded into the soft tissue...
December 12, 2016: Dento Maxillo Facial Radiology
https://www.readbyqxmd.com/read/27935922/maxillary-calcifying-epithelial-odontogenic-tumour
#16
S Acharya, N Prusty, C Naik, K Kumar
The calcifying epithelial odontogenic tumor is a benign, locally invasive, slow-growing neoplasm occurring as intraosseous (94%) and extraosseous (6%) variants and with a frequency of 1-2%. Extraosseous variant is diagnosed slightly earlier than the intraosseous type. The intraosseous CEOT shows a maxilla:mandible site ratio of 1:2 and are mainly located in the premolar/molar region. Histologically, the CEOT is characterized by the occurrence of sheets, nests and masses of polyhedral, eosinophilic epithelial cells which may show cellular abnormalities including giant cell formation and nuclear pleomorphism...
July 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/27935113/fak-is-overexpressed-in-keratocystic-odontogenic-tumor-a-preliminary-study
#17
Sachin C Sarode, Gargi S Sarode, Shakira Choudhary, Shankargouda Patil
BACKGROUND: Focal adhesion kinase (FAK) is an important mediator of cell adhesion, growth proliferation, survival, angiogenesis, and migration. FAK is over expressed in many locally invasive and malignant lesions including oral cancer. Looking at the tumorigenic nature of keratocystic odontogenic tumor (KCOT), which involves local invasion, proliferation, and recurrence, we hypothesized strong expression of FAK in the epithelial lining of KCOT. MATERIALS AND METHODS: 34 KCOTs, 11 orthokeratinized odontogenic cysts (OOCs), 25 radicular cysts (RCs), 17 dentigerous cysts (DCs) and 25 dental follicles (DFs) were retrieved from archives and subjected to the immunohistochemical analysis using FAK antibody...
December 9, 2016: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/27902954/multi-recurrent-invasive-ameloblastoma-a-surgical-challenge
#18
Fatemah Faras, Fawaz Abo-Alhassan, Yona Israël, Barbara Hersant, Jean-Paul Meningaud
INTRODUCTION: Ameloblastomas are rare head and neck tumors, and yet the most common odontogenic neoplasms. They account for 1% and 11% of all head and neck and odontogenic tumors respectively. Embryologically, they originate from remnants of odontogenic epithelium. Their aggressive, destructive nature, as well as their anticipated high rate of recurrence, even after en bloc resection, poses a surgical predicament. PRESENTATION: We present a case of a 56 year-old Asian female with a multi-recurrent invasive ameloblastoma...
November 21, 2016: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/27891488/management-of-recurrent-odontogenic-myxoma-of-mandible-a-clinical-case-report
#19
Yogesh Mittal, Ankita Chugh, K George Varghese, Shailendra Dwivedi, Vidhi Goyal
Odontogenic Myxoma (OM) is a slow growing painless locally aggressive tumor seen in gnathic bones and is generally asymptomatic. OM is characterized by spindle, wedge or stellate shaped cells loosely arranged in an abundant mucoid stroma. It is found incidentally on radiographs and may vary from a unilocular radiolucency to a multilocular lesion with well-defined or diffuse margins. Treatment includes surgical management that may range from simple enucleation and curettage to surgical excision including peripheral osteotomy, segmental resection, hemimandibulectomy and maxillectomy...
October 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27891277/a-case-of-ameloblastic-fibroodontoma-extending-maxillary-sinus-with-erupted-tooth-is-transcanine-approach-with-alveolectomy-feasible
#20
Mustafa Aslıer, Mustafa Cenk Ecevit, Sülen Sarıoğlu, Semih Sütay
Ameloblastic fibroodontoma (AFO) is a rare entity of mixed odontogenic tumors and frequently arises from posterior portion of the maxilla or mandible in first two decades of life. Herein, a 35-year-old woman with a noncontributory medical history who presented with a progressive left maxillary toothache, left maxillary first molar tooth mobility, and swelling in the left maxillary molar area for the last 2 months was reported. Radiologically, a tumor that originated from periapical area of the second mature molar teeth of maxilla was seen and additively unerupted tooth was not detected...
2016: Case Reports in Otolaryngology
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