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Odontogenic tumor

Chengshuai Yang, Shunyao Shen, Jingyang Wu, Shilei Zhang
Mandibular reconstruction after partial or subtotal resection is considered a challenging procedure that is crucial for facial contour and function. Many reports regarding the reconstruction of mandibular defects have been published over the years. The fibula free flap has become a popular option for mandibular reconstruction since its introduction by Hidalgo in 1989. However, the locations of the reconstructed mandibular angle and the condyle of the fibular bone segments play a crucial role in facial symmetry and function...
February 20, 2018: Journal of Oral and Maxillofacial Surgery
Farzaneh Mosavat, Roxana Rashtchian, Negar Zeini, Daryoush Goodarzi Pour, Shabnam Mohammed Charlie, Nazanin Mahdavi
Adenomatoid odontogenic tumor (AOT) is a rare noninvasive odontogenic tumor that occurs mostly in the second decade of life. Based on its tooth association, AOT can be classified into three categories of follicular, extrafollicular, and peripheral types; the follicular classification is considered as the most common type of AOT. This study reported a large extrafollicular case of AOT in a 40-year-old female. She was asymptomatic and tumor was detected accidentally by her dental practitioner. Since the panoramic radiograph showed a well-defined unilocular radiolucent lesion, we observed radiopaque spots within the lesion by using cone beam computed tomography...
2018: Case Reports in Radiology
Evelyn Nathalia, Madelaine Skolastika Theardy, Sharleen Elvira, Graciella Rosellinny, Andrew Steven Liyanto, Michael Putra Utama, Anton Sumarpo
INTRODUCTION: LIM Homeobox 6 (LHX6) encodes a LIM homeodomain transcription factor, contributes to tissue development and morphogenesis, and is mostly expressed in medial ganglionic eminence and odontogenic mesenchyme. However, it has been reported to play a role in cancer progression. This narrative review summarizes literatures that emphasize the molecular regulation of LHX6 in tumorigenesis. METHODS: In our systematic review, the PubMed database was used for the literature search using the combination of words that included "LHX6" and "cancer"...
March 9, 2018: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
Marcos Custódio, Juliane Pirágine Araujo, Camila de Barros Gallo, Marília Trierveiler
Odontomas are odontogenic tumors composed of a mixture of dental tissues. They are very common hamartomas of the jaws. However, their peripheral or gingival counterparts are extremely uncommon. The objective of this article is to report a rare case of gingival complex odontoma in an 11-year-old patient, and also to review all published cases of this type of lesion.
January 2018: Autopsy & Case Reports
Achla Bharti Yadav, Mala Kamboj, Anjali Narwal, Anju Devi
Statement of the Problem: Histopathology is a gold standard diagnostic tool for oral lesions. Nonspecific and overlapping microscopic features often pose diagnostic challenges in routine practice. In such conditions, deeper sections have utility to enhance the sensitivity and accuracy of the diagnosis. Purpose: To analyze the percentage of deeper sections requested and to evaluate the diagnostic efficacy of these deeper sections in routine oral histopathology practice...
March 2018: Journal of Dentistry
Annaji Araleri Gopalkrishna, B N Tejasree, M Manjunath, D P Ashwin
Odontogenic keratocyst(OKC)is a cyst oftooth origin with an aggressive behavior including a high recurrence rate, it has been rechristened to keratocystic odontogenic tumor(KCOT) as it be the reflects its neoplastic nature. We report a case of KCOT in association with an impacted supernumerary tooth along with Trigeminal Neuralgia, that subsided by itself after removal of the cyst.
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Saede Atarbashi-Moghadam, Ali Lotfi, Sepideh Mokhtari
Ameloblastic fibro-odontosarcoma (AFOS) is an extremely rare malignant mixed odontogenic tumor. The ectomesenchymal part of the neoplasm shows malignancy, whereas the epithelial component is rather benign. In addition, small areas with deposition of enamel matrix and dentine material are seen. The rarity of this neoplasm and microscopic similarities with other malignant and benign tumors can lead to diagnostic problems. Here, we describe the histopathologic features of a new case of AFOS of the mandible in a 34-year-old female patient...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Aparna Venigalla, Manasa Bojji, Soujanya Pinisetti, Suresh Babburi
Ameloblastoma is a benign epithelial odontogenic tumor with many histological variants. Hemangiomatous ameloblastoma (HA) is a very rare variant which shows unique histopathological features varying from conventional ameloblastoma. We present a case of a 35-year-old female patient with a swelling over right lower back region of jaw, showing mixed radiolucent-opacity. Incisional biopsy showed microscopic features of desmoplastic ameloblastoma showing extensive desmoplasia and compressed odontogenic epithelial islands...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Mamata Kamat, Sampada Kanitkar, Uma Datar, Sanjay Byakodi
Orthokeratinized odontogenic cyst (OOC) is a relatively rare odontogenic cyst, distinct from odontogenic keratocyst (OKC). In the 4th edition of WHO Classification of Head and Neck Tumors (2017), OOC has been included as a separate entity in the category of developmental odontogenic cysts. It presents as a unilocular radiolucent lesion in the posterior mandible and is frequently related to impacted teeth, thus mimicking dentigerous cyst. Due to low local aggressiveness and no association with nevoid basal cell carcinoma syndrome, it does not show tendency to recur...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Sana Shaikh, Shivani Bansal, Rajiv S Desai, Islam Ahmad
Adenomatoid odontogenic tumor (AOT) is a relatively rare and distinct odontogenic tumor that is exclusively odontogenic epithelium in origin. Although considerable numbers of reports are available with regard to the clinical and histological spectrum of AOT, very few have highlighted its rare aggressive nature. This article focuses on an AOT causing jaw swelling in the mandibular anterior region with cortical plate expansion and perforation, root resorption and paresthesia. The present case had remarkably unusual clinical and radiographic features that distinguished it from most conventional AOTs and supported its neoplastic nature...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Sugunakar Raju Godishala Swamy, Sushma Naag, Sumit Bahl, Esther Priyadarshini
Odontogenic myxoma is a benign locally aggressive neoplasm with a sparse prevalence and incertitude histogenesis. They constitute 3%-6% of odontogenic tumors in gnathic bones. It is ubiquitously seen between vicenarian to early quadragenarian group with female proclivity and fondness to the mandibular jaws. They are silent lesions clinically and show myxoid stroma amidst fibrous background. This report highlights central odontogenic myxoma in a 43-year-old male patient and focuses on concepts, differential diagnosis, molecular concepts and treatment aspect...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
Kipp Wingo
This retrospective study documents the prevalence of various histopathological diagnoses within a practice specializing in veterinary dentistry and oral surgery. Histopathology results obtained from biopsies of oral lesions from 403 dogs and 73 cats were sorted and categorized. Lesions of inflammatory origin represented the most common histopathology result in cats (n = 37; 51%), followed by squamous cell carcinoma (n = 27; 37%). The most common histopathological diagnoses in dogs were malignant neoplasms (n = 151; 37%), followed by tumors of odontogenic origin (n = 138, 34%) and lesions of inflammatory origin (n = 114; 28%)...
March 2018: Journal of Veterinary Dentistry
R Bologna-Molina, T Mikami, V Pereira-Prado, G Tapia-Repetto, F R Pires, R Carlos, A Mosqueda-Taylor
Primordial odontogenic tumor (POT) is composed of variably cellular myxoid connective tissue, surrounded by cuboidal to columnar odontogenic epithelium resembling the inner epithelium of the enamel organ, which often invaginates into the underlying connective tissue. The tumor is delimited at least partially by a thin fibrous capsule. It derives from the early stages of tooth development. Syndecan-1 is a heparan sulfate proteoglycan that has a physiological role in several cellular functions, including maintenance of the epithelial architecture, cell-to-cell adhesion and interaction of cells with extracellular matrix, and with diverse growth factors, stimulating cell proliferation...
March 2018: Oral Diseases
M Kreppel, J Zöller
Ameloblastoma are the most common odontogenic tumor. As they usually do not form metastasis, they are considered as benign tumors with a locally invasive growth pattern and destruction of the jaws and the surrounding tissue (Oral Diseases, 23, 2017, 199). This article focuses on clinical, radiological, and therapeutic findings, which may influence diagnosis and treatment of ameloblastoma in the future.
March 2018: Oral Diseases
Dize Li, Zhiqiang Yang, Tao Chen, Chao Guan, Feilong Wang, Ethan L Matz, Yuanyuan Zhang, Ping Ji
Cone beam computed tomography (CBCT) has obvious advantages over regular radiography in diagnosis of complex diseases. Objective of this study is to report a case of a mandibular jaw ameloblastoma recurring cyst, which represents a benign tumor of odontogenic epithelium, using CBCT imaging technology. CBCT examination of the patient suffering with recurrent lower jaw cyst (relapsing four years after surgery) showed a decrease in irregular bone density and appearance of a honeycomb pattern (3.5 cm×2.5 cm×1...
2018: Journal of X-ray Science and Technology
J-R Tenório, T Santana, S-I-M-L Queiroz, D-H-I-P de Oliveira, L-M-G Queiroz
BACKGROUND: Ameloblastoma (AMB), odontogenic keratocyst (OKC) and adenomatoid odontogenic tumor (AOT) are epithelial odontogenic lesions with diverse biologic profiles. Defects in regulation of apoptosis and cell cycle may be involved in the development and progression of those lesions, therefore we aimed to investigate the expression of Bcl-2, Bax and p53 to better understand the possible role of these proteins in AMBs, OKCs and AOTs. MATERIAL AND METHODS: The studied sample consisted of 20 AMBs, 20 OKCs and 20 AOTs...
February 24, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
Anasuya Guha, Libor Hart, Helena Polachova, Martin Chovanec, Petr Schalek
BACKGROUND: Ameloblastoma represents the most common epithelial odontogenic tumor. Because of the proximity of the maxillary tumors to the orbit and skull base, it should be managed as radically as possible. Maxillectomy mainly via the transfacial or transoral approach represents the most common type of surgical procedure. Drawback of these approaches is limited control of the superiomedial extent of the tumour in the paranasal area. We report the use of a combined endoscopic endonasal and transoral approach to manage maxillary plexiform ameloblastoma in a 48 year old male patient...
February 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
Taynara Asevedo Campos de Resende, Vanessa de Fátima Bernardes, Jéssica Carolina da Silva, Luiz Armando De Marco, Ricardo Santiago Gomez, Carolina Cavalieri Gomes, Marina Gonçalves Diniz
OBJECTIVES: The odontogenic keratocyst (OKC) is an aggressive odontogenic cyst that has a high recurrence rate. Apart from PTCH1 mutations, few molecular alterations are described in OKCs. Low expression of microRNAs (miRNAs) miR-15a and/or miR-16-1 in association with increased expression of their target, Bcl-2, have been previously found in OKC. In humans, MIR15A and MIR16-1 are clustered at chromosome position 13 q14, and loss of heterozygosity (LOH) at this locus occurs in different tumors...
January 31, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Soichiro Sonoda, Yu-Feng Mei, Ikiru Atsuta, Atsushi Danjo, Haruyoshi Yamaza, Shion Hama, Kento Nishida, Ronghao Tang, Yukari Kyumoto-Nakamura, Norihisa Uehara, Toshio Kukita, Fusanori Nishimura, Takayoshi Yamaza
Nitric oxide (NO) is thought to play a pivotal regulatory role in dental pulp tissues under both physiological and pathological conditions. However, little is known about the NO functions in dental pulp stem cells (DPSCs). We examined the direct actions of a spontaneous NO gas-releasing donor, NOC-18, on the odontogenic capacity of rat DPSCs (rDPSCs). In the presence of NOC-18, rDPSCs were transformed into odontoblast-like cells with long cytoplasmic processes and a polarized nucleus. NOC-18 treatment increased alkaline phosphatase activity and enhanced dentin-like mineralized tissue formation and the expression levels of several odontoblast-specific genes, such as runt related factor 2, dentin matrix protein 1 and dentin sialophosphoprotein, in rDPSCs...
February 21, 2018: Scientific Reports
B Ae O Khalele
Adenomatoid odontogenic tumor (AOT) is always benign. Given the very rare recurrence rate and the zero potential of malignant transformation, authors have considered it a hamartoma. Accordingly, 'AOT' is no more than a misnomer. This report, however, describes the first recognition of cellular atypia and plemorphism in a peripheral orophayrngeal AOT which embraces an ameloblastic component. The overall picture was diagnosed, after careful histological and immunohitochemical assessment, as a peripheral adenoid ameloblastoma...
December 2017: Pathologica
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