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Odontogenic tumor

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https://www.readbyqxmd.com/read/29768520/clinical-and-immunohistochemical-study-of-melanotic-neuroectodermal-tumor-of-infancy-in-the-maxilla
#1
Hellen Bandeira de Pontes Santos, Aníbal Henrique Barbosa de Luna, Pedro Everton Marques Goes, Alexander Tadeu Sverzut, Cassiano Francisco Weege Nonaka, Pollianna Muniz Alves
Melanotic neuroectodermal tumor of infancy is a rare and fast-growing neoplasm. In this study, we describe the case of a 6-month-old female patient, who presented swelling in the anterior maxilla. Tomographic reconstruction showed an unilocular hypodense and expansive area associated with the upper right central primary incisor. The presumptive diagnoses were dentigerous cyst, adenomatoid odontogenic tumor, melanotic neuroectodermal tumor of infancy and rhabdomyosarcoma, and an incisional biopsy was performed...
May 14, 2018: Einstein
https://www.readbyqxmd.com/read/29753697/giant-dentinogenic-ghost-cell-tumor-a-case-report
#2
Ciro Dantas Soares, Roman Carlos, Thayná Melo de Lima Morais, Oslei Paes de Almeida
Dentinogenic ghost cell tumor (DGCT), a rare, benign odontogenic tumor with aggressive behavior, causes bone destruction and cortical expansion. We report here a case of DGCT in a 38-year-old male, presenting with enormous extraoral protrusion, which radiographically was predominantly radiolucent with radiopaque areas. Microscopically, it was observed to be a solid ameloblastomatous proliferation with pseudoglandular structures associated with clusters of ghost cells. Abundant dentinoid material adjacent to the epithelial sheets containing entrapped epithelial tumor cells was also evident...
April 18, 2018: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/29749993/central-acinic-cell-carcinoma-of-the-mandible-simulating-as-benign-odontogenic-lesion-a-case-report
#3
Manas Bajpai, Nilesh Pardhe, Betina Chandolia, Manika Arora
Centrally occurring salivary gland tumors are rare. Because of a considerable overlap between the clinical and histopathological features, this group of tumors often produces a diagnostic difficulty to the clinicians and oral pathologists. Acinic cell carcinoma (ACC) is an unusual, low-grade, malignant salivary gland tumor that represents approximately 2% of the salivary gland tumors with almost 90% arising in the parotid gland. The rest involve the submandibular and the minor salivary gland. ACC of the jaw is extremely rare and, to our knowledge, only 8 cases have been reported in the English literature...
March 2018: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/29747056/brain-ameloblastoma-metastasis-or-local-extension-report-of-a-case-and-literature-review
#4
Jérémie Bettoni, Cécilia Neiva, Charlie Demarteleire, Sylvie Testelin, Bernard Devauchelle, Stéphanie Dakpé
Background Ameloblastoma is a rare benign odontogenic tumor with a metastasis rate estimated at 2% of cases, mainly involving the lung (80%) and lymph nodes (20%). Methods We hereby present the case of a 26 year old patient with a history of locally recurrent mandibular ameloblastoma who developed a temporal intracranial ameloblastoma tumor requiring a collaborative neurosurgical and maxillo-facial radical surgical approach. Conclusion Although ameloblastomas are histologically benign, the temporal topography questions the dissemination pathophysiology of the tumor (metastasis or local extension through temporal muscle fibers), mainly relevant in cases of multiple recurrences...
May 7, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29738629/calcifying-odontogenic-cyst-dentinogenic-ghost-cell-tumor-and-ghost-cell-odontogenic-carcinoma-a-systematic-review
#5
REVIEW
José Alcides Almeida de Arruda, João Luiz Gomes Carneiro Monteiro, Lucas Guimarães Abreu, Leni Verônica de Oliveira Silva, Lauren Frenzel Schuch, Mariana Saturnino de Noronha, Gerhilde Callou, Amália Moreno, Ricardo Alves Mesquita
BACKGROUND: The aim of this study was to integrate the available data published on calcifying odontogenic cyst (COC), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinomas (GCOC) into a comprehensive analysis of their clinicoradiological features, treatment and recurrence. MATERIALS AND METHODS: An electronic search with no publication date restriction was undertaken in October 2017 in the following databases: PubMed, Medline Ovid, Web of Science and Scopus...
May 8, 2018: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/29731583/dentinogenic-ghost-cell-tumor-tumor-in-the-garb-of-a-cyst
#6
Vaishali Korranne, Yash Merchant, Samir Joshi, Rajshekhar Halli
The dentinogenic ghost cell tumor (DGCT) is a relatively uncommon locally invasive neoplasm that mimics several inflammatory/reactive lesions of the gingiva or odontogenic cysts. The confirmatory diagnosis of this rare lesion can only be made with histopathological examination. Routine staining reveals features of a "mixed" tumor as ghost cells with calcification, dysplastic dentin and islands of epithelium in rosette pattern in mature connective tissue are visible. The case report describes an asymptomatic growth in the maxillary gingiva of a young patient that was incidentally diagnosed as a DGCT after biopsy...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29731564/proteoglycans-as-potential-biomarkers-in-odontogenic-tumors
#7
REVIEW
Zaira Gómez-Herrera, Nelly Molina-Frechero, Pablo Damián-Matsumura, Ronell Bologna-Molina
Proteoglycans (PGs) are essential for normal cellular development; however, alterations of their concentrations can promote tumor growth. To date, a limited number of studies report the presence of PGs in odontogenic tumors (OTs); therefore, the main purpose of this work is to gather the information published on the study of PGs. The search reported 26 articles referring to the presence of different PGs in distinct OTs from 1999 to May 2017. PGs seem to play an important role during OTs' development as they are involved in several tumor processes; however, the number of reports on the study of these molecules is low...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29721233/dentigerous-cyst-with-parietal-and-intracystic-calcifications-a-case-report-and-literature-review
#8
Jordi Borrás-Ferreres, Alba Sánchez-Torres, José-Manuel Aguirre-Urizar, Cosme Gay-Escoda
Background: Dentigerous cyst appears surrounding the crown of an included tooth. On the radiographic exam, a radiolucent rounded well-defined lesion can be observed. Material and Methods: This study reports a clinical case of a 34-years old man with a pericoronal radiolucent lesion associated to an impacted lower third molar with the presence of radiopaque material inside. The radiological differential diagnosis was calcifying odontogenic tumor, adenomatoid odontogenic tumor and dentigerous cyst...
March 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29695670/peripheral-clear-cell-variant-of-calcifying-epithelial-odontogenic-tumor-devoid-of-calcification
#9
Jun Kurihara, Shiro Mori, Mariko Oikawa, Hiroyuki Kumamoto, Tetsu Takahashi
A clear cell variant of calcifying epithelial odontogenic tumor (CCEOT) affecting an extraosseous site is described. A 60-year-old male patient presented with gingival swelling on the lingual side of the anterior mandible. The results of biopsy suggested clear cell odontogenic carcinoma, and marginal resection of the mandible was performed. The resected specimen was composed of eosinophilic and clear cells with deposits of amyloid-like material. The clear cells exhibited granules that were positive for PAS...
April 25, 2018: Journal of Oral Science
https://www.readbyqxmd.com/read/29683236/odontogenic-myxoma-an-updated-analysis-of-1692-cases-reported-in-the-literature
#10
REVIEW
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
OBJECTIVE: To integrate the available data published on odontogenic myxoma (OM) into a comprehensive analysis of its clinical/radiologic features. METHODS: Electronic search undertaken in January/2018, looking for publications reporting cases of OM. RESULTS: 377 publications included. We identified 1692 lesions and 695 were used for analysis of recurrence. There is predominance of OMs in females and in mandibles. OMs usually present with bone expansion, asymptomatic cortical perforation, multilocular...
April 23, 2018: Oral Diseases
https://www.readbyqxmd.com/read/29682262/unicystic-ameloblastoma-rehabilitation-with-chin-graft-harvested-and-implant-supported-fixed-prosthesis
#11
J Sanz-Alonso, N Martínez-Rodríguez, M Martín-Ares, C Barona-Dorado, J Cortés Bretón-Brinkmann, J M Martínez-González
Objective: The objective is to present a clinical case of a 38-year-old male with a maxillary unicystic ameloblastoma treated by means of tumor block resection followed by chin-harvested graft placement in order to place two dental implants for esthetic and functional rehabilitation. Methods: Ameloblastoma is a benign odontogenic tumor characterized by local aggression and a high rate of recurrence; the latter partly depends on how it is treated. Complete resection of the tumor, which usually prevents recurrence, produces bone defects of varying size that must be reconstructed later on...
October 2017: Oral & Implantology
https://www.readbyqxmd.com/read/29680857/evaluation-of-the-osteoclastogenic-process-associated-with-rank-rank-l-opg-in-odontogenic-myxomas
#12
M-D Gonzalez-Galvan, A Mosqueda-Taylor, R Bologna-Molina, A Setien-Olarra, X Marichalar-Mendia, J-M Aguirre-Urizar
BACKGROUND: Odontogenic myxoma (OM) is a benign intraosseous neoplasm that exhibits local aggressiveness and high recurrence rates. Osteoclastogenesis is an important phenomenon in the tumor growth of maxillary neoplasms. RANK (Receptor Activator of Nuclear Factor κappa B) is the signaling receptor of RANK-L (Receptor activator of nuclear factor kappa-Β ligand) that activates the osteoclasts. OPG (osteoprotegerin) is a decoy receptor for RANK-L that inhibits pro-osteoclastogenesis. The RANK / RANKL / OPG system participates in the regulation of osteolytic activity under normal conditions, and its alteration has been associated with greater bone destruction, and also with tumor growth...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680843/oral-peripheral-ameloblastoma-a-retrospective-series-study-of-25-cases
#13
X Zhang, X Tian, Y Hu, C Zhang, C Wei, X Yang
BACKGROUND: Peripheral ameloblastoma (PA) is a rare and unusual variant of odontogenic tumor, which was described only in isolated case reports in literature. The objective of this study was to investigate the clinical profile, treatment and outcome of PA in a consecutive case series. MATERIAL AND METHODS: A total of 25 patients with histologically confirmed PA from 2001 to 2015 were retrospectively reviewed in our institution. RESULTS: Of the 25 patients, 22 males and 3 females were identified (male: female = 7...
April 22, 2018: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29680775/numb-chin-syndrome-a-reflection-of-malignancy-or-a-harbinger-of-mronj-a-multicenter-experience
#14
Leonzio Fortunato, Massimo Amato, Michele Simeone, Francesco Bennardo, Selene Barone, Amerigo Giudice
INTRODUCTION: Numb chin syndrome (NCS) or mental neuropathy (MN) is a disorder characterized by sensory neuropathy on the distribution of the inferior alveolar nerve or mental nerve. The most frequent causes are of odontogenic origin (infections, wrong therapies). Other etiologies are related to primary tumor, metastasis, osteoradionecrosis and medication-related osteonecrosis of the jaw (MRONJ). The aim of this study is to highlight the clinical importance of NCS as one of the first symptoms of cancer or as consequence of drug therapy...
April 20, 2018: Journal of Stomatology, Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29676382/peripheral-variant-of-calcifying-epithelial-odontogenic-tumor-with-clear-cell-changes-an-enigma
#15
Manas Bajpai
No abstract text is available yet for this article.
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29676366/pindborg-tumor-pathology-with-special-stains
#16
Swati Shrikant Gotmare, Treville Pereira, Subraj Shetty, Kashmira S Kesarkar
Odontogenic tumors constitute a wide spectrum of lesions ranging from malignant and benign neoplasms to dental hamartomas, all derived from the epithelial and ectomesenchymal remnants of the tooth forming apparatus. Calcifying epithelial odontogenic tumor (CEOT) is an uncommon, benign epithelial odontogenic tumor first described by Pindborg in 1956. It is a universally accepted eponym for this neoplasm. Pindborg tumor or CEOT is a locally aggressive neoplasm that accounts for 1% of the total odontogenic tumors, with recurrence in 14% of cases...
April 2018: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/29663916/a-bag-of-marbles-a-fascinating-compound-odontoma-of-the-maxilla
#17
Aneesh Kalra, Evelyn C Sheehy, Joanna Johnson, Fraser McDonald
Odontomas are the most common odontogenic tumors, typically diagnosed during the first two decades of life. 1 The purpose of this paper was to report an interesting case of an eight-year-old Caucasian boy who presented with an asymptomatic, progressive, firm swelling of the right maxilla with no eruption of the permanent maxillary right lateral incisor. Radiographic investigation revealed a mixed radiolucent and radiopaque lesion measuring 28 by 24 by 17 mm with a corticated border causing expansion and thinning of the buccal cortical plate...
March 15, 2018: Pediatric Dentistry
https://www.readbyqxmd.com/read/29657523/comparison-of-osteoclastogenesis-and-local-invasiveness-of-ameloblastoma-and-keratocystic-odontogenic-tumor
#18
Natheer H Al-Rawi, Ammar K Al-Siraj, Ahlam H Majeed
Objectives: The aim of this study was to compare the expression of receptor-activated nuclear factor kappa B (RANK) with its ligand (RANKL) and matrix metalloproteinase-2 (MMP2) in solid/multicystic ameloblastomas (ABs) and keratocystic odontogenic tumors (KOTs). Materials and Methods: The expression of MMP2, RANK, and RANKL molecules was evaluated in 13 ABs and 14 KOTs by immunohistochemistry. The expressions were calculated in the odontogenic epithelial cells as well as the stromal cells...
January 2018: European Journal of Dentistry
https://www.readbyqxmd.com/read/29652021/an-unusual-presentation-of-ghost-cell-odontogenic-carcinoma-a-case-report-with-review-of-literature
#19
K Remya, S Sudha, Reshmi G Nair, H Jyothi
Ghost cell odontogenic carcinoma (GCOC) is a malignant odontogenic epithelial tumor which is an exceedingly rare, highly aggressive, rapidly growing, and infiltrative tumor forming the malignant counterpart of long-standing benign cystic lesions coming in the spectrum of calcifying odontogenic cysts. To date, only a few cases have been reported in the medical literature. A case of unusual presentation of GCOC is presented and the clinical, histopathological, and immunohistochemical features are discussed along with a literature review...
March 2018: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/29650947/hsa-let-7c-controls-the-committed-differentiation-of-igf-1-treated-mesenchymal-stem-cells-derived-from-dental-pulps-by-targeting-igf-1r-via-the-mapk-pathways
#20
Gen-Xia Liu, Shu Ma, Yao Li, Yan Yu, Yi-Xiang Zhou, Ya-Die Lu, Lin Jin, Zi-Lu Wang, Jin-Hua Yu
The putative tumor suppressor microRNA let-7c is extensively associated with the biological properties of cancer cells. However, the potential involvement of let-7c in the differentiation of mesenchymal stem cells has not been fully explored. In this study, we investigated the influence of hsa-let-7c (let-7c) on the proliferation and differentiation of human dental pulp-derived mesenchymal stem cells (DPMSCs) treated with insulin-like growth factor 1 (IGF-1) via flow cytometry, CCK-8 assays, alizarin red staining, real-time RT-PCR, and western blotting...
April 13, 2018: Experimental & Molecular Medicine
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