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Odontogenic tumor

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https://www.readbyqxmd.com/read/28635992/odontogenic-tumors-a-retrospective-clinicopathological-study-from-two-italian-centers
#1
C Rubini, M Mascitti, A Santarelli, A Tempesta, L Limongelli, G Favia, E Maiorano
Objective: The aim of this retrospective study was to perform an epidemiological analysis of all odontogenic tumors treated in the University Hospitals "Ospedali Riuniti" in Ancona and "Policlinico" in Bari, from 1990 to 2015. Materials and methods: A retrospective survey of 277 patients treated for odontogenic tumors from 1990 to 2015 was performed. Data were retrieved from the archives of the above quoted Sections of Pathology. The lesions were classified according to 2005 WHO histological classification, and the following variables were analyzed: age, sex, histopathological diagnosis, site distribution, tumor size, and relapses...
March 2017: Pathologica
https://www.readbyqxmd.com/read/28631627/ameloblastoma-a-16-year-clinicopathological-study-on-goan-population
#2
Karla Maria Carvalho, Anita Dhupar, Anita Spadigam, Shaheen Syed
BACKGROUND: Ameloblastoma is a benign slow growing tumor of odontogenic origin composed of epithelial cells that resemble enamel forming cells namely the ameloblasts however these lesional cells do not differentiate to produce enamel. They are locally aggressive and can cause severe abnormalities of the face and jaw. AIM: This study aimed to correlate the incidence and recurrence rates of ameloblastoma to the different clinical and histopathological parameters. METHODS: A study on ameloblastomas in the Goan population for 16 years (1999-2014) was carried out...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28617410/-prof-v-a-semkin-and-prof-i-i-babichenko-odontogenous-cysts-and-tumors-diagnosis-and-treatment-textbook-review
#3
(no author information available yet)
No abstract text is available yet for this article.
2017: Stomatologii︠a︡
https://www.readbyqxmd.com/read/28611319/assessing-alpha-tocopherol-levels-in-patients-with-keratocystic-odontogenic-tumor-a-cross-sectional-study
#4
Bhargavi Krishna Ayinampudi, Sushmita Bhargavi Varikoti, Pacha Venkat Baghirath, B Hari Vinay, Ch Gayathri, Ashalata Gannepalli
AIMS AND OBJECTIVES: A keratocystic odontogenic tumour (KCOT) is a benign uni- or multicystic, intraosseous tumour of odontogenic origin, with a characteristic lining of parakeratinized stratified squamous epithelium and potential for aggressive, infiltrative behaviour. Various studies in hamsters showed that, alpha-Tocopherol, which is an active biological form of Vitamin E, is a potent antioxidant known to inhibit tumour formation and also regression of established tumours. So, the aim of the present pilot study was to assess the levels of Alpha-Tocopherol(Vitamin E) in Patients with KCOT and compare them with Vitamin E levels in normal healthy individuals...
March 2017: Indian Journal of Dental Research: Official Publication of Indian Society for Dental Research
https://www.readbyqxmd.com/read/28601296/calcifying-epithelial-odontogenic-tumor-an-updated-analysis-of-339-cases-reported-in-the-literature
#5
Bruno Ramos Chrcanovic, Ricardo Santiago Gomez
PURPOSE: The aim of this study was to integrate the available data published on calcifying epithelial odontogenic tumors (CEOT) into a comprehensive analysis of its clinical and radiologic features. MATERIALS AND METHODS: An electronic search was undertaken in May 2016. Eligibility criteria were publications having enough clinical, radiological and/or histological information to confirm definite diagnosis. RESULTS: A total of 362 lesions were found, 339 with enough information were analyzed...
May 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28600599/pattern-of-care-and-impact-of-prognostic-factors-in-the-outcome-of-ameloblastic-carcinoma-a-systematic-review-and-individual-patient-data-analysis-of-199-cases
#6
Prashanth Giridhar, Supriya Mallick, Ashish Datt Upadhyay, Goura K Rath
Ameloblastic carcinoma is a rare locally aggressive odontogenic neoplasm. These tumors are most commonly found to arise from mandible. Because of rarity, there is limited information about the clinical behaviour of such patients. We intended to perform this review of published literature to assess the demographic profile, pattern of care and assess survival outcomes. Two authors independently searched PubMed, Google search, and Cochrane library for eligible studies from 1950 until July 1 2016 published in English language...
June 9, 2017: European Archives of Oto-rhino-laryngology
https://www.readbyqxmd.com/read/28597929/next-generation-sequencing-of-oncogenes-and-tumor-suppressor-genes-in-odontogenic-myxomas
#7
Jean Nunes Dos Santos, Ernesto Santos Sousa Neto, Josiane Alves França, Marina Gonçalves Diniz, Rennan Garcias Moreira, Wagner Henriques Castro, Ricardo Santiago Gomez, Silvia Ferreira de Sousa, Carolina Cavalieri Gomes
BACKGROUND: Mutations previously considered drivers of malignant neoplasms also occur in benign tumors. From the biological perspective, the study of malignant and benign neoplasms is equally relevant. The study of rare tumors contributes to the understanding of the more common ones, as both could share the same hallmark genetic drivers. The identification of driver mutations in benign tumors is facilitated by the fact that they harbor quiet genomes. Pathogenic mutations have being described in benign epithelial odontogenic tumors, such as ameloblastomas and adenomatoid odontogenic tumors...
June 8, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28584748/papilliferous-keratoameloblastoma-a-rare-case-report
#8
Ajit Singh Rathore, Saurabh Juneja, Neha Khurana, Devi Charan Shetty
Ameloblastoma is true odontogenic tumor of epithelial origin, which is described as locally aggressive with varying chances of recurrence. It is believed to derive from enamel organ, remnants of dental lamina, lining of odontogenic cysts, or basal cells of oral epithelium. Radiologically, it may present as unilocular or multilocular radiolucency commonly. Although conventional ameloblastoma presents typical histological features as described by Vickers and Gorlin, few unusual variants have been reported with different histological patterns...
April 2017: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/28584604/p53-protein-expression-in-dental-follicle-dentigerous-cyst-odontogenic-keratocyst-and-inflammatory-subtypes-of-cysts-an-immunohistochemical-study
#9
Mashhadiabbas Fatemeh, Arab Sepideh, Bagheri Seyedeh Sara, Mahdavi Nazanin
OBJECTIVES: An odontogenic keratocyst (OKC) is a developmental odontogenic cyst with aggressive clinical behavior. This cyst shows a different growth mechanism from the more common dentigerous cyst and now has been renamed as a keratocystic odontogenic tumor (KCOT). Inflammation can assist tumor growth via different mechanisms including dysregulation of the p53 gene. This study aims to assess and compare the expression of tumor suppressor gene p53 in inflamed and non-inflamed types of OKC and dentigerous cyst...
May 2017: Oman Medical Journal
https://www.readbyqxmd.com/read/28559020/establishment-and-characterization-of-a-clear-cell-odontogenic-carcinoma-cell-line-with-ewsr1-atf1-fusion-gene
#10
Satoko Kujiraoka, Takaaki Tsunematsu, Yukiko Sato, Maki Yoshida, Ayataka Ishikawa, Rei Tohyama, Michio Tanaka, Yutaka Kobayashi, Tomoyuki Kondo, Aya Ushio, Kunihiro Otsuka, Mie Kurosawa, Masako Saito, Akiko Yamada, Rieko Arakaki, Hirokazu Nagai, Hiromasa Nikai, Kengo Takeuchi, Toshitaka Nagao, Youji Miyamoto, Naozumi Ishimaru, Yasusei Kudo
OBJECTIVE: Clear cell odontogenic carcinoma (CCOC) is a rare malignant odontogenic tumor (MOT) characterized by sheets and lobules of vacuolated and clear cells. To understand the biology of CCOC, we established a new cell line, CCOC-T, with EWSR1-ATF1 fusion gene from a mandible tumor with distant metastasis and characterized this cell line. MATERIALS AND METHODS: To detect the EWSR1-ATF1 fusion gene, we used three CCOC cases, including the present case, by RT-PCR and FISH analysis...
June 2017: Oral Oncology
https://www.readbyqxmd.com/read/28558942/bone-margin-analysis-for-benign-odontogenic-tumors
#11
REVIEW
Eric Ringer, Antonia Kolokythas
With the potential exception of the case of ameloblastoma, information relevant to the exact tumor-bone interface and extent of bone invasion by the commonly encountered odontogenic tumors is lacking. These tumors are rare. Treatment rendered varies significantly. Although commonly accepted practices are recommended, scientific evidence is relatively lacking. Prospective multicenter studies from tertiary treatment centers are required for evidence-based guidelines. Until studies are available, the proposed linear bone resection margin for odontogenic tumors and the evaluation of its adequacy in tumor eradication will be based on the limited data available...
May 27, 2017: Oral and Maxillofacial Surgery Clinics of North America
https://www.readbyqxmd.com/read/28557592/ameloblastic-fibro-odontoma-of-the-maxilla-in-a-pierre-robin-sequence-patient
#12
Kenneth Kufta, Steve Kang, Faizan Alawi, Anna Moran, Neeraj Panchal
INTRODUCTION: Pierre Robin sequence (PRS) is a rare disorder classically observed as a triad of features including micrognathia, glossoptosis, and upper airway obstruction. It is associated with a syndrome in about 60% of cases. While odontogenic tumors are common findings in patients with familial adenomatous polyposis and nevoid basal cell carcinoma syndromes, PRS has not been found to be consistently associated with any tumors of the jaw. CASE REPORT: The current report aims to describe a patient with PRS who presented with an extensive ameloblastic fibro-odontoma (AFO) of the maxilla...
May 30, 2017: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/28545325/mandibular-odontoameloblastoma-in-a-rat-and-a-horse
#13
Brian Murphy, Cynthia Bell, Amanda Koehne, Richard R Dubielzig
Odontoameloblastoma (OA) is a mixed odontogenic tumor that is an ameloblastoma with concurrent histologic evidence of odontoma differentiation. As a mixed tumor, OA is a tripartite lesion comprised of neoplastic odontogenic epithelium, induced dental ectomesenchyme (dental pulp), and mineralized dental matrix. Although rare, OA represents a diagnostic conundrum, as it is histologically closely related to 2 other mixed odontogenic tumors: odontoma (complex and compound) and ameloblastic fibro-odontoma. Herein we describe an OA arising from the mandible of a 4-mo-old Fischer 344 rat that had been exposed in utero to the mutagen ENU (N-ethyl-N-nitrosourea), and a naturally occurring lesion in a 2-y-old Appaloosa horse...
May 1, 2017: Journal of Veterinary Diagnostic Investigation
https://www.readbyqxmd.com/read/28543986/a-case-of-primordial-odontogenic-tumor-a-new-entity-in-the-latest-who-classification-2017
#14
Toshinori Ando, Madhu Shrestha, Takashi Nakamoto, Kaori Uchisako, Sachiko Yamasaki, Koichi Koizumi, Ikuko Ogawa, Mutsumi Miyauchi, Takashi Takata
Primordial odontogenic tumor (POT) is a rare lesion in the jaw which has been included as a new entity of benign mixed epithelial and mesenchymal odontogenic tumour in the latest World Health Organization (WHO) classification (2017). Only seven cases have been reported. It typically occurs in the posterior mandible. We report an additional case of POT in the maxilla of an 8-year-old girl presenting with an asymptomatic buccal enlargement. A well-defined, unilocular, radiolucent lesion was observed radiographically...
May 25, 2017: Pathology International
https://www.readbyqxmd.com/read/28521454/histopathological-and-immunohistochemical-study-in-keratocystic-odontogenic-tumors-predictive-factors-of-recurrence
#15
Tomofumi Naruse, Kentaro Yamashita, Souichi Yanamoto, Satoshi Rokutanda, Yuki Matsushita, Yuki Sakamoto, Hiroshi Sakamoto, Hisazumi Ikeda, Tohru Ikeda, Izumi Asahina, Masahiro Umeda
The aim of the present study was to identify the most useful markers for predicting recurrence of keratocystic odontogenic tumors (KCOTs). A total of 65 tumor samples from 63 patients diagnosed with typical parakeratinized cysts and KCOTs between 1992 and 2014 were retrospectively studied. Clinical and histopathological data and treatment modality were reviewed. In addition, the expression profiles of Ki-67, cluster of differentiation (CD)34 and podoplanin were assessed using immunohistochemistry. The association between these factors and the rate of KCOT recurrence was evaluated...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28512636/expression-of-yap-taz-in-keratocystic-odontogenic-tumors-and-its-possible-association-with-proliferative-behavior
#16
Qi-Wen Man, Yan-Qi Ma, Jin-Yuan Liu, Yi Zhao, Bing Liu, Yi-Fang Zhao
The aim of this study is to clarify whether YAP/TAZ is involved in the pathogenesis and proliferative growth of keratocystic odontogenic tumor (KCOT). The expression levels of YAP/TAZ and downstream proteins and genes in normal oral mucosa (OM) and KCOT were determined and compared by immunohistochemistry and real-time quantitative PCR. The results showed that the expression of YAP/TAZ and downstream proteins (Cyr61, CTGF) was significantly upregulated in KCOT with upregulation of Ki-67 compared to OM. Importantly, the mRNA levels of transcription factors (TEAD1, TEAD4, and RUNX2) and cell cycle related genes (CDK2, PCNA), which interact with the transcriptional coactivators YAP/TAZ, are also upregulated in the KCOT...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28510282/cytologic-features-of-a-feline-inductive-odontogenic-tumor
#17
Ronaldo V Leite-Filho, Nelson J Tagliari, Fabrizio Grandi, Cláudio J M Laisse, Daniel G Gerardi, Saulo P Pavarini
The feline inductive odontogenic tumor (FIOT) is a rare entity among oral tumors in cats, the cytologic features of which are not well characterized but may prove useful. A fine-needle aspiration biopsy was performed on the right mandible between the permanent canine (404) and permanent fourth premolar (408) of an 8-month-old female mongrel cat. Cytologic smears showed epithelial cells and occasional spindle cells with extracellular homogenous acidophilic material in a hematic background. The initial diagnosis of benign tumor was confirmed by histopathologic examination of the biopsy specimen...
May 16, 2017: Veterinary Clinical Pathology
https://www.readbyqxmd.com/read/28508997/fibromyxoma-of-the-jaw-case-report-and-review-of-the-literature
#18
Thabet Alhousami, Amarpreet Sabharwal, Shivane Gupta, Alfredo Aguirre, Etern Park, Jill M Kramer
We report a case of fibromyxoma of the mandible, a rare benign odontogenic tumor. Our patient presented in the first trimester of pregnancy with a large mass in the right body of the mandible exhibiting displacement of teeth and destruction of an extensive area of the mandibular bone. The mass was biopsied and diagnosed as a fibromyxoma. The large size of the tumor dictated a wide mandibular resection. We will review the clinical, radiographic, and histologic features of fibromyxoma and discuss its differential diagnoses...
May 16, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28503263/spontaneous-peripheral-ameloblastic-odontoma-in-a-male-sprague-dawley-rat
#19
Yinghua Li, Han-Ik Bae, Hak-Soo Kim, Min-Soo Kang, Bo-Ho Gong, Won-Hee Jung, Sranna Lee, Jin-Sook Bae, Kap-Ho Kim, Si-Whan Song, Jae-Hyun Lee, Boo-Hyon Kang
Peripheral ameloblastic odontoma is a rare variant of odontogenic tumor occurring in the extraosseous region. The present report describes a spontaneous tumor in male Sprague-Dawley (SD) rats. The clinically confirmed nodule in the right mandibular region was first observed when the rat was 42 weeks and remained until the terminal sacrifice date when the animal was 48 weeks of age. At necropsy, a well demarcated nodule, approximately 2.5 × 2.0 × 2.0 cm, protruded from the ventral area of the right mandible...
April 2017: Toxicological Research
https://www.readbyqxmd.com/read/28502762/clear-cell-odontogenic-carcinoma-diagnostic-difficulties-a-case-report
#20
U Ordioni, G Benat, M Hadj Saïd, A Gomez-Brouchet, C Chossegros, J-H Catherine
INTRODUCTION: Clear cell odontogenic carcinoma (COCC) is a rare tumor described by Hansen et al. in 1985. The clinical and radiological manifestations are multiple and the diagnosis is histological. OBSERVATION: A 64-year-old patient consulted us for a right mandibular osteolytic lesion associated to a homolateral labial hypoesthesia. A biopsy was performed under local anesthesia. Histology was consistent with a metastatic lesion of clear kidney cell carcinoma, COCC, or odontogenic squamous tumor...
May 11, 2017: Journal of Stomatology, Oral and Maxillofacial Surgery
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