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Odontogenic tumor

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https://www.readbyqxmd.com/read/29136303/chromosome-9-mutations-reported-absent-in-some-patients-with-basal-cell-carcinoma-nevus-syndrome
#1
S Shih, B A Urso, R Domozych, K M Updyke, A I Laughlin, J A Solomon
Basal Cell Carcinoma Nevus Syndrome (BCCNS), also known as Gorlin syndrome, is a rare autosomal dominant condition with a substantial disease burden, thought to occur secondary to chromosome 9 mutation evoking a Hedgehog (Hh) signaling aberration that leads to early development of numerous basal cell carcinomas (BCCs). Individuals with BCCNS also present with keratocystic odontogenic tumors, medulloblastomas, and palmar or plantar pits1. This condition demonstrates variable expressivity, leading to differing phenotypes, even within the same family2...
November 14, 2017: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/29126490/dental-management-of-patients-who-have-undergone-oral-cancer-therapy
#2
REVIEW
Alessandro Villa, Sunday O Akintoye
Oral cancer therapies are associated with orofacial complications that could result in dose-limiting cancer treatment and consequent suboptimal tumor control. Oral cancer treatment complications include oral mucositis, salivary gland hypofunction, odontogenic infections, pain, dermatitis, neurotoxicity, soft tissue fibrosis, trismus, osteoradionecrosis, and potential cancer recurrence. These complications significantly affect cancer survivorship, quality of life, and psychosocial status. Effective dental management of patients with oral cancer involves the coordination of care among several health care professionals before, during, and after cancer therapy...
January 2018: Dental Clinics of North America
https://www.readbyqxmd.com/read/29113208/calcifying-cystic-odontogenic-tumor-accompanied-by-a-dentigerous-cyst-a-case-report
#3
Shoko Gamoh, Hironori Akiyama, Chisato Furukawa, Yuki Matsushima, Tomio Iseki, Masahiro Wato, Akio Tanaka, Shosuke Morita, Kimishige Shimizutani
A calcifying cystic odontogenic tumor (CCOT) is a proliferation of odontogenic epithelium and scattered nests of ghost cells and calcifications that may form the lining of a cyst, or present as a solid mass. It was previously described by Gorlin et al in 1962 as a calcifying odontogenic cyst. Dentigerous cysts are developmental odontogenic jaw cysts, commonly manifesting in the second and third decades of life. The present study reports an asymptomatic case in a 13-year-old boy who was referred to the outpatient clinic of the Osaka Dental University Hospital (Osaka, Japan) for additional investigation of an area of radiolucency in the lower right jaw...
November 2017: Oncology Letters
https://www.readbyqxmd.com/read/29109321/epidemiological-and-clinicopathological-analysis-of-92-odontogenic-tumors-a-5-year-retrospective-study
#4
Ipsita Sharma, Deepa Venkatesh, Geetanjali Bawa, Syed Vaseemuddin, Amit Joseph, Jimmy K Sangtani
INTRODUCTION: Odontogenic tumors (OTs) are a heterogeneous group of lesions that are derived from odontogenic apparatus comprised of odontogenic epithelium, ectomesenchyme, and/ or mesenchymal elements. The OTs show marked geographical variation. This study was conducted to analyze the epidemiology and clinicopathological presentation of OTs based on age, sex, and site. MATERIALS AND METHODS: This study was conducted in Department of Oral Pathology and Microbiology...
November 1, 2017: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/29103753/frequent-oncogenic-braf-v600e-mutation-in-odontogenic-keratocyst
#5
Yong Hoon Cha, Eunae Sandra Cho, Hee Eun Kang, Jaemin Ko, Woong Nam, Hyung Jun Kim, Nam Hee Kim, Hyun Sil Kim, In-Ho Cha, Jong In Yook
OBJECTIVES: Odontogenic keratocyst (OKC), also known as keratocystic odontogenic tumor (KCOT), has clinical significance due to its high incidence as well as high recurrence rate after surgical enucleation. Current clinical management for OCK is entirely dependent on surgical approach. While various genetic alterations, such as PTCH1 mutation and loss of heterozygosity in tumor suppressor genes, have been reported, the molecular background of OKC is not well-understood. Although recent identification of BRAF V600E mutation and subsequent activation of mitogen-activated protein kinase (MAPK) pathway in ameloblastoma and odontogenic tumors provide additional options with targeted therapeutics, the molecular background of OKC is not well understood...
November 2017: Oral Oncology
https://www.readbyqxmd.com/read/29099370/metachronous-ameloblastic-fibro-odontoma-and-dentigerous-cyst-in-the-posterior-mandible
#6
Mário Rodrigues de Melo Filho, Sabina Pena Borges Pêgo, Claudio Marcelo Cardoso, Breno Amaral Rocha, Hercílio Martelli-Júnior, Isadora Luana Flores, Luis Antônio Nogueira Dos Santos, Livia Máris Ribeiro Paranaiba
An ameloblastic fibro-odontoma (AFO) is a rare mixed odontogenic tumor with histologic features of an ameloblastic fibroma in conjunction with the presence of dentin and enamel. It usually appears as a well-circumscribed radiolucency with radiopaque foci and slow growth and is commonly seen in children and young adults. A 13-year-old boy presented with an asymptomatic swelling in the posterior right region of the mandible and the right ascending ramus. The clinical, imaging, and histopathologic findings confirmed the diagnosis of an AFO...
November 2017: General Dentistry
https://www.readbyqxmd.com/read/29090496/primordial-odontogenic-tumor-a-case-report-with-histopathological-analyses
#7
Toshinari Mikami, Yu Ohashi, Ronell Bologna-Molina, Adalberto Mosqueda-Taylor, Naoki Fujiwara, Naoko Tsunoda, Hiroyuki Yamada, Yasunori Takeda
Primordial odontogenic tumor (POT) is a benign mixed epithelial and mesenchymal odontogenic tumor included into the current World Health Organization (WHO) classification of Head and Neck tumours in 2017. As far as the authors have confirmed, only eight cases of this tumor have been reported so far. This paper reports a case of POT that occurred in the right mandible of a 5-year-old patient. Panoramic radiograph showed a well-defined homogeneous radiolucency displacing the unerupted second deciduous molar to the deep part of the mandible...
November 1, 2017: Pathology International
https://www.readbyqxmd.com/read/29075421/cone-beam-computed-tomography-diagnostic-imaging-of-intra-osseous-mucoepidermoid-carcinoma-in-the-mandible
#8
Andre-Luiz-Ferreira Costa, Thasia-Luiz-Dias Ferreira, Haroldo-Arid Soares, Ana-Carla-Raphaelli Nahas-Scocate, Gonzalo-André-Parra Montesinos, Paulo-Henrique Braz-Silva
Intra-osseous mucoepidermoid carcinoma in the mandible is a rarely reported entity, comprising only 2-3% of all mucoepidermoid carcinomas. Unilocular and/or multilocular radiolucency is characteristic of mucoepidermoid carcinoma, but has a radiographic appearance similar to that of odontogenic benign and malignant tumors and thus cannot be accurately diagnosed on plain films. This article describes a case of a 36-year-old man with intra-osseous mucoepidermoid carcinoma in the left mandible. For a detailed analysis, both panoramic radiograph and cone beam computed tomograph were taken...
September 2017: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29053755/micrornas-expression-profile-in-solid-and-unicystic-ameloblastomas
#9
A Setién-Olarra, X Marichalar-Mendia, N G Bediaga, P Aguirre-Echebarria, J M Aguirre-Urizar, A Mosqueda-Taylor
OBJECTIVES: Odontogenic tumors (OT) represent a specific pathological category that includes some lesions with unpredictable biological behavior. Although most of these lesions are benign, some, such as the ameloblastoma, exhibit local aggressiveness and high recurrence rates. The most common types of ameloblastoma are the solid/multicystic (SA) and the unicystic ameloblastoma (UA); the latter considered a much less aggressive entity as compared to the SA. The microRNA system regulates the expression of many human genes while its deregulation has been associated with neoplastic development...
2017: PloS One
https://www.readbyqxmd.com/read/29053654/retrospective-analysis-of-jaw-biopsies-in-young-adults-a-study-of-1599-cases-in-southern-brazil
#10
K Silva, A Alves, M Correa, A Etges, A-C Vasconcelos, A-P Gomes, S Tarquinio
BACKGROUND: To evaluate the prevalence and the characteristics of jaw lesions diagnosed in young adults aged 20 to 30 years in a southern Brazil reference center, over a period of 25 years. And to analyze the concordance between clinical and histological diagnosis. MATERIAL AND METHODS: In this cross-sectional retrospective study, the biopsies files from this center were retrieved and data regarding sex, age, bone localization, clinical and histological diagnosis were collected...
November 1, 2017: Medicina Oral, Patología Oral y Cirugía Bucal
https://www.readbyqxmd.com/read/29039452/molecular-analysis-of-keratocystic-odontogenic-tumor-cell-lines-derived-from-sporadic-and-basal-cell-nevus-syndrome-patients
#11
Kazuma Noguchi, Keiko Wakai, Tohru Kiyono, Mutsuki Kawabe, Kyohei Yoshikawa, Tomoko Hashimoto-Tamaoki, Hiromitsu Kishimoto, Yoshiro Nakano
Keratocystic odontogenic tumor (KCOT) is a benign tumor often associated with basal cell nevus syndrome (BCNS). Mutations in Patched 1 (PTCH1), the Hedgehog (Hh) receptor, are responsible for BCNS. BCNS is distinguished by morphological anomalies and predisposition to benign and malignant tumors, including medulloblastoma, basal cell carcinoma, KCOT and ovarian fibromas. Among these tumors, KCOT is the least well studied because a suitable model system is not available for its investigation. To enable KCOT to be studied, we established two KCOT cell lines, one from a BCNS case (designated as iKCOT1) and one from a sporadic KCOT case (designated as sKCOT1)...
October 9, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/29034280/ameloblastic-fibro-odontoma-in-a-7-month-old-infant-a-case-report
#12
Fatemeh Mashhadiabba, Nafiseh Shamloo, Mehdi Jafari, Shahla Vafadar
Ameloblastic fibro-odontoma is a relatively rare, benign odontogenic tumor that usually occurs in children and adolescents with unerupted teeth. This article reports an ameloblastic fibro-odontoma in the anterior mandible as a "bump on her gum" in a 7-month-old girl. This is the first case under 9 months old reported to date. Radiographic and histologic findings as well as the treatment are discussed.
September 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/29017682/calcifying-cystic-odontogenic-tumor
#13
Muhammad Zeeshan Baig, Haafsa Arshad Sahibzada, Khalid Mahmood Siddiqi
No abstract text is available yet for this article.
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28985009/odontogenic-myxoma-a-63-year-retrospective-multicenter-study-of-85-cases-in-a-brazil-population-and-a-review-of-999-cases-from-literature
#14
Ana Carolina Uchoa Vasconcelos, Felipe Martins Silveira, Ana Paula Neutzling Gomes, Sandra Beatriz Chaves Tarquinio, Ana Paula Veras Sobral, José Alcides Almeida de Arruda, Leorik Pereira da Silva, Marcia Maria Fonseca da Silveira, Larissa Ferreira Barbosa, Camila de Nazaré Alves de Oliveira Kato, Filipe Jaeger, Tarcília Aparecida da Silva, Ricardo Alves Mesquita
BACKGROUND: Odontogenic myxoma (OM) is an uncommon neoplasm of the jaws. Considering the importance of defining the relative incidence and demographic profile of these lesions in South America, the aim of this study was to analyze the clinical and imagiological features of OM from three South American oral pathology services and to discuss these findings in light of the literature. METHODS: Data regarding age, gender, anatomic site, and imagiological features from 85 cases of OM were collected...
October 6, 2017: Journal of Oral Pathology & Medicine
https://www.readbyqxmd.com/read/28984343/the-world-health-organization-classification-of-odontogenic-lesions-a-summary-of-the-changes-of-the-2017-4th-edition
#15
Merva Soluk-Tekkeşin, John M Wright
The 4 < sup > th < /sup > edition of the World Health Organization (WHO) Classification of Head and Neck Tumors was published in January 2017. The edition serves to provide an updated classification scheme, and extended genetic and molecular data that are useful as diagnostic tools for the lesions of the head and neck region. This review focuses on the most current update of odontogenic cysts and tumors based on the 2017 WHO edition. The updated classification has some important differences from the 3 < sup > rd < /sup > edition (2005), including a new classification of odontogenic cysts, 'reclassified' odontogenic tumors, and some new entities...
October 6, 2017: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/28978273/clinical-characterization-of-canine-acanthomatous-ameloblastoma-caa-in-263-dogs-and-the-influence-of-postsurgical-histopathological-margin-on-local-recurrence
#16
Stephanie L Goldschmidt, Cindy M Bell, Scott Hetzel, Jason Soukup
Canine acanthomatous ameloblastoma (CAA) has been reported to be the most common odontogenic tumor in dogs. This retrospective study evaluated 263 dogs with histopathologically confirmed CAA. Within this data set, CAA presents most commonly in the rostral mandible in adult large breed dogs, with golden retriever dogs being overrepresented. Patients with appropriate follow-up after curative intent surgery were evaluated to assess the effect of histopathological margin on local tumor recurrence. No local recurrence was noted in any patient...
January 1, 2017: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28969743/ortho-keratinized-odontogenic-cyst-with-dentinoid-formation
#17
Manas Bajpai, Nilesh Pardhe, Manika Aroroa, Betina Chandolia
Orthokeratinized odontogenic keratocyst (OOC) was first identified as orthokeratinized variant of odontogenic keratocyst in 1981 by Wright, due to its different histology and relatively low recurrence rate. Parakeratinized odontogenic cyst is now considered as keratocystic odontogenic tumor (KCOT) owing to its neoplastic nature. Although rare, calcification in the form of dystrophic calcification, dentinoid and cartilage has been reported in KCOT, but calcification in OOC is extremely rare and no case in English literature has been reported so far...
September 2017: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/28968331/reconstruction-of-mandibular-segmental-detects-using-transport-disk-distraction-osteogenesis
#18
Tao Li, Yi Man, Ruiye Bi, Nan Jiang, Yunfeng Li, Songsong Zhu
BACKGROUND: Distraction osteogenesis (DO) has become an important alternative for bone defect reconstruction. The study aims to investigate the clinical feasibility and efficiency of transport disc DO (TDDO) for reconstruction of segmental defect of mandible and further dental implant treatment. METHODS: A serial of 6 patients diagnosed with ameloblastoma or keratocystic odontogenic tumor were included in this study. Computed tomography (CT) scanning and panoramic radiograph were performed for preoperative evaluation and surgery planning...
November 2017: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/28944145/rare-case-of-ameloblastoma-with-pulmonary-metastases
#19
Ivan Valkadinov, Nikolay Conev, Dian Dzhenkov, Ivan Donev
Ameloblastoma is a rare low-grade odontogenic tumor of epithelial origin. The World Health Organization (WHO) has defined malignant ameloblastoma (MA) as a histologically benign-appearing ameloblastoma that has metastasized. Treatment of the primary ameloblastoma usually consists of radical excision of the tumor and adjuvant radiotherapy. Chemotherapy should be used to treat metastases due to its indolent clinical course. Presented here is the case of a 43-year-old woman who was admitted to a hospital in 2006 with a large mass involving the neck and left mandible...
August 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/28932057/erratum-odontogenic-tumor-indian-scenario
#20
(no author information available yet)
[This corrects the article on p. 2 in vol. 21, PMID: 28479677.].
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
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