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https://www.readbyqxmd.com/read/28412804/-status-and-analysis-of-off-label-drug-use-in-department-of-ophthalmology
#1
F R Han, H Y Zhao, L Li, J W Wang
Objective: To investigate and analyze the status of off-label drug use in department of ophthalmology of Beijing Tongren Hospital. Methods: Cross-sectional study. Prescription evaluation, off-label drug use application and temporary medicine purchase application were collected from January 2013 to March 2015. The off-label use of medication in department of ophthalmology were filtered out and analyzed according to the category of medications, the category of the off-label use of medication and the strength of evidence for the off-label use of medication...
April 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28407829/-application-of-pulmonary-function-and-fractional-exhaled-nitric-oxide-tests-in-the-standardized-management-of-bronchial-asthma-in-children
#2
Hui-Qin Zhang, Hui-Qin Zhang, Jing-Jing Zhang, Yu-Dong Liu, Yue-Lin Deng, Jian-Feng Luo, Huan-Hong Niu, Xin Sun
OBJECTIVE: To investigate the changes of pulmonary function and fractional exhaled nitric oxide (FeNO) in the standardized treatment of bronchial asthma in children. METHODS: A total of 254 children who were newly diagnosed with acute exacerbation of bronchial asthma were selected as asthma group, and they were divided into two subgroups: asthma with concurrent rhinitis and asthma without concurrent rhinitis. All patients received the standardized management and treatment for one year...
April 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28407139/economic-impact-of-remote-monitoring-after-implantable-defibrillators-implantation-in-heart-failure-patients-an-analysis-from-the-effect-study
#3
Alessandro Capucci, Antonio De Simone, Mario Luzi, Valeria Calvi, Giuseppe Stabile, Antonio D'Onofrio, Simone Maffei, Loira Leoni, Giovanni Morani, Raffaele Sangiuolo, Claudia Amellone, Catia Checchinato, Ernesto Ammendola, Gianfranco Buja
Aims: Heart failure (HF) patients with implantable cardioverter-defibrillators (ICD) require admissions for disease management and out-patient visits for disease management and assessment of device performance. These admissions place a significant burden on the National Health Service. Remote monitoring (RM) is an effective alternative to frequent hospital visits. The EFFECT study was a multicentre observational investigation aiming to evaluate the clinical effectiveness of RM compared with in-office visits standard management (SM)...
April 12, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28402981/prenatal-nonvisualization-of-the-gallbladder-a-diagnostic-and-prognostic-dilemma
#4
Aina Ruiz, Ana Robles, Francisca Salva, Ana Filgueira, Cristina Díaz, Miquel Juan, Albert Tubau
INTRODUCTION: Nonvisualization of the fetal gallbladder has been associated with benign conditions such as isolated gallbladder agenesis or severe diseases such as biliary atresia (BA). Recently, gamma-glutamyl transpeptidase (GGTP) fetal blood levels were reported as useful after 22 weeks. OBJECTIVE: To determine the contribution of fetal blood GGTP levels after 22 weeks, based on 2 cases. Case 1: 20+4-week secundipara, with subcutaneous edema and pleural effusion...
April 13, 2017: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/28393434/multivisceral-transplantation-for-abdominal-tumors-in-children-a-single-center-experience-and-review-of-the-literature
#5
Eliza Lee, Nicole Hodgkinson, Rima Fawaz, Khashayar Vakili, Heung Bae Kim
Standard management of intra-abdominal pediatric solid tumors requires complete resection. However, tumors with multiple organ and vascular involvement present a unique surgical challenge. We conducted a retrospective chart review of four patients, aged 2-14 years, undergoing MVT for intra-abdominal tumors with significant involvement of the visceral arteries and/or portomesenteric venous system at our institution. Indications for MVT included hepatocellular carcinoma, inflammatory myofibroblastic tumor, and two cases of hepatoblastoma...
April 9, 2017: Pediatric Transplantation
https://www.readbyqxmd.com/read/28382875/effects-of-environmental-enrichment-and-regrouping-on-natural-autoantibodies-binding-danger-and-neural-antigens-in-healthy-pigs-with-different-individual-characteristics
#6
L Luo, R Geers, I Reimert, B Kemp, H K Parmentier, J E Bolhuis
Pigs living in commercial husbandry systems may experience both acute stress due to standard management procedures and chronic stress through limitations in their barren housing environment. This might influence their immune status, including antibody responses to neural and danger autoantigens. Levels of natural autoantibody (NAAb)-binding phosphorylcholine-conjugated bovine serum albumin (PC-BSA) and myelin basic protein (MBP) were measured over time in pigs that were kept in environmental enriched v. barren housing, and that underwent a regrouping test...
April 6, 2017: Animal: An International Journal of Animal Bioscience
https://www.readbyqxmd.com/read/28381928/prevalence-of-shunt-dependency-and-clinical-outcome-in-patients-with-massive-intraventricular-haemorrhage-treated-with-endoscopic-washout-and-external-ventricular-drainage
#7
Jason Raj Johnson, Zamzuri Idris, Jafri Malin Abdullah, Azmi Alias, Mohammad Saffari Mohammad Haspani
BACKGROUND: Intraventricular haemorrhage (IVH) causes blockage of ventricular conduits leading to hydrocephalus, increased intracranial pressure (ICP), and a reduced level of consciousness. The current standard management of IVH is insertion of an external ventricular drainage (EVD) catheter. However, this procedure addresses only the problems of acute hydrocephalus and raised ICP. Endoscopic washout allows for a more complete removal of the intraventricular clot. This study compared these two types of treatment in terms of shunt dependency and relevant clinical outcomes...
March 2017: Malaysian Journal of Medical Sciences: MJMS
https://www.readbyqxmd.com/read/28346663/management-of-stage-iii-colon-cancer-in-the-elderly-practice-patterns-and-outcomes-in-the-general-population
#8
Shaila J Merchant, Sulaiman Nanji, Kelly Brennan, Safiya Karim, Sunil V Patel, James J Biagi, Christopher M Booth
BACKGROUND: Clinical trials have established surgical resection and adjuvant chemotherapy (ACT) as the standard management for stage III colon cancer; however, the extent to which these results apply to elderly patients in routine practice is unclear. This article describes the management and outcomes of elderly patients with stage III colon cancer. METHODS: All cases of surgically resected colon cancer from 2002 to 2008 were identified with the population-based Ontario Cancer Registry...
March 27, 2017: Cancer
https://www.readbyqxmd.com/read/28339483/temporal-evolution-of-vasospasm-and-clinical-outcome-after-intra-arterial-vasodilator-therapy-in-patients-with-aneurysmal-subarachnoid-hemorrhage
#9
Laleh Daftari Besheli, Can Ozan Tan, Donnie L Bell, Joshua A Hirsch, Rajiv Gupta
Intra-arterial (IA) vasodilator therapy is one of the recommended treatments to minimize the impact of aneurysmal subarachnoid hemorrhage-induced cerebral vasospasm refractory to standard management. However, its usefulness and efficacy is not well established. We evaluated the effect IA vasodilator therapy on middle cerebral artery blood flow and on discharge outcome. We reviewed records for 115 adults admitted to Neurointensive Care Unit to test whether there was a difference in clinical outcome (discharge mRS) in those who received IA infusions...
2017: PloS One
https://www.readbyqxmd.com/read/28319931/bet-1-tranexamic-acid-in-epistaxis-who-bloody-nose
#10
Nicola Penrose, Gabby May
A shortcut review was carried out to establish whether tranexamic acid is effective in controlling epistaxis. Three studies were directly relevant to the question. The author, date and country of publication, patient group studied, study type, relevant outcomes, results and study weaknesses of these studies are tabulated. The clinical bottom line is that there is not enough evidence to recommend tranexamic acid in the standard management of epistaxis.
November 2016: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/28300036/-inflammatory-myofibroblastic-genitourinary-tumor-the-challenge-of-controlling-and-monitoring-an-non-frequent-oncological-disease
#11
Luis Rico, Francisco Miguel López, Gonzalo Vitagliano, Ameri Carlos
OBJECTIVE: The inflammatory myofibroblastic tumor (IMT) is a neoplasia with intermediate biological potential, infrequent, with an unpredictable clinical prognosis and a low recurrence rate after an effective treatment. We report two cases of IMT with genitourinary localization, being this entit's publications infrequent. Both presented with little symptomatology, leading to multiple differential diagnosis. The surgical treatment was chosen and pathologic result confirmed the diagnosis...
March 2017: Archivos Españoles de Urología
https://www.readbyqxmd.com/read/28293629/food-waste-to-energy-an-overview-of-sustainable-approaches-for-food-waste-management-and-nutrient-recycling
#12
REVIEW
Kunwar Paritosh, Sandeep K Kushwaha, Monika Yadav, Nidhi Pareek, Aakash Chawade, Vivekanand Vivekanand
Food wastage and its accumulation are becoming a critical problem around the globe due to continuous increase of the world population. The exponential growth in food waste is imposing serious threats to our society like environmental pollution, health risk, and scarcity of dumping land. There is an urgent need to take appropriate measures to reduce food waste burden by adopting standard management practices. Currently, various kinds of approaches are investigated in waste food processing and management for societal benefits and applications...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28258861/-management-of-infants-whose-diagnosis-is-inconclusive-at-neonatal-screening-for-cystic-fibrosis
#13
I Sermet-Gaudelus, J Brouard, M-P Audrézet, L Couderc Kohen, L Weiss, N Wizla, S Vrielynck, K LLerena, M Le Bourgeois, E Deneuville, N Remus, T Nguyen-Khoa, C Raynal, M Roussey, E Girodon
Neonatal screening for cystic fibrosis (CF) may detect infants with elevated immunoreactive trypsinogen (IRT) levels but with inconclusive sweat tests and/or DNA results. This includes cases associating (1) either the presence of at most one CF-causing mutation and sweat chloride values between 30 and 59mmol/L or (2) two CFTR mutations with at least one of unknown pathogenicity and a sweat chloride below 60mmol/L. This encompasses different clinical situations whose progression cannot be predicted. These cases require redoing the sweat test at 12 months and if possible at 6 and 24 months of life...
March 1, 2017: Archives de Pédiatrie: Organe Officiel de la Sociéte Française de Pédiatrie
https://www.readbyqxmd.com/read/28251254/-side-effects-of-chemotherapy
#14
K Hauner, P Maisch, M Retz
Urologic tumors are frequently treated by multimodal therapeutic strategies with the consequence of an increasing number of adverse events. The most common chemotherapy-induced side effects are neutropenia, stomatitis, mucositis, diarrhea, and emesis. The efficacy of tumor therapy can be improved by good prophylaxis and standardized management of side effects.
March 1, 2017: Der Urologe. Ausg. A
https://www.readbyqxmd.com/read/28244952/prophylactic-phenylephrine-infusions-to-reduce-severe-spinal-anesthesia-hypotension-during-cesarean-delivery-in-a-resource-constrained-environment
#15
David G Bishop, Carel Cairns, Mariette Grobbelaar, Reitze N Rodseth
Phenylephrine infusions are considered as standard management for obstetric spinal hypotension, but there remains reluctance to implement them in resource-limited contexts. This prospective, alternating intervention study of patients undergoing elective or urgent cesarean delivery under spinal anesthesia compared a vasopressor bolus strategy to fixed-rate, low-dose prophylactic phenylephrine infusion with supplemental boluses. The primary outcome was the incidence of severe hypotension (mean arterial pressure <70% baseline or systolic blood pressure <80 mm Hg)...
February 24, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28225967/synchronous-melanomas-arising-within-nevus-spilus
#16
Maria Helena Toda Sanches de Brito, Cecília Silva Nunes de Moura Dionísio, Cândida Margarida Branco Martins Fernandes, Joana Cintia Monteiro Ferreira, Maria Joaninha Madalena de Palma Mendonça da Costa Rosa, Maria Manuela Antunes Pecegueiro da Silva Garcia
Nevus spilus is a melanocytic cutaneous lesion consisting of a light brown background macule with numerous superimposed darker maculopapular speckles. Melanoma arising from a nevus spilus is rare, with less than 40 cases reported to date. The absolute risk for malignant transformation is not well defined, lacking a standardized management approach. We report a new case of melanoma arising from nevus spilus, with the additional peculiarity of multifocality. We offer our recommendations for the management of the condition...
January 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28206933/use-of-antibiotic-impregnated-absorbable-beads-and-tissue-coverage-of-complex-wounds
#17
MULTICENTER STUDY
Terris L White, Alfred T Culliford, Martin Zomaya, Gary Freed, Christopher P Demas
The treatment of complex wounds is commonplace for plastic surgeons. Standard management is debridement of infected and devitalized tissue and systemic antibiotic therapy. In cases where vital structures are exposed within the wound, coverage is obtained with the use of vascularized tissue using both muscle and fasciocutaneous flaps. The use of nondissolving polymethylmethacrylate and absorbable antibiotic-impregnated beads has been shown to deliver high concentrations of antibiotics with low systemic levels of the same antibiotic...
November 1, 2016: American Surgeon
https://www.readbyqxmd.com/read/28183347/application-of-incident-command-structure-to-clinical-trial-management-in-the-academic-setting-principles-and-lessons-learned
#18
Penny S Reynolds, Mary J Michael, Bruce D Spiess
BACKGROUND: Clinical trial success depends on appropriate management, but practical guidance to trial organisation and planning is lacking. The Incident Command System (ICS) is the 'gold standard' management system developed for managing diverse operations in major incident and public health arenas. It enables effective and flexible management through integration of personnel, procedures, resources, and communications within a common hierarchical organisational structure. Conventional ICS organisation consists of five function modules: Command, Planning, Operations, Logistics, and Finance/Administration...
February 9, 2017: Trials
https://www.readbyqxmd.com/read/28183146/prenatal-and-postnatal-management-of-gastroschisis-in-german-speaking-countries-is-there-a-standardized-management
#19
Katharina Schib, Marc Schumacher, Martin Meuli, Sasha Tharakan, Ulrike Subotic
Introduction Evidence-based guidelines or protocols regarding the perinatal management of babies born with gastroschisis are lacking. The aim of this work is to evaluate the different current treatment modalities for newborns with gastroschisis during the perinatal period in the German-speaking countries Germany, Austria, and Switzerland. These data could serve as a starting point for the development of a multicenter randomized controlled trial. Materials and Methods A questionnaire was developed with 30 questions divided into five sections: (1) prenatal diagnosis, (2) fetal therapy, (3) mode and timing of delivery, (4) operative management, and (5) postoperative management...
February 9, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28179438/management-of-continuous-positive-airway-pressure-treatment-compliance-using-telemonitoring-in-obstructive-sleep-apnoea
#20
Cecilia Turino, Jordi de Batlle, Holger Woehrle, Ana Mayoral, Anabel Lourdes Castro-Grattoni, Sílvia Gómez, Mireia Dalmases, Manuel Sánchez-de-la-Torre, Ferran Barbé
Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnoea (OSA), but treatment compliance is often unsatisfactory. This study investigated the efficacy and cost-effectiveness of telemonitoring for improving CPAP compliance.100 newly diagnosed OSA patients requiring CPAP (apnoea-hypopnoea index >15 events·h(-1)) were randomised to standard management or a telemonitoring programme that collected daily information about compliance, air leaks and residual respiratory events, and initiated patient contact to resolve issues...
February 2017: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
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