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https://www.readbyqxmd.com/read/29786758/long-term-complete-remission-following-tandem-autologous-stem-cell-transplantation-and-consolidative-radiotherapy-for-refractory-mediastinal-gray-zone-lymphoma
#1
Koji Takaishi, Tomoya Muto, Naoya Mimura, Jun Takiguchi, Yuhei Nagao, Nagisa Oshima-Hasegawa, Shokichi Tsukamoto, Yusuke Takeda, Shio Mitsukawa, Masahiro Takeuchi, Chikako Ohwada, Satoshi Ota, Tohru Iseki, Chiaki Nakaseko, Emiko Sakaida
Mediastinal gray zone lymphoma (MGZL) is a provisional entity with intermediate features between classical Hodgkin lymphoma (cHL) and diffuse large B-cell lymphoma. Outcomes for patients with MGZL are reportedly poorer than those for patients with cHL or primary mediastinal large B-cell lymphoma. Additionally, no standard management guidelines for patients with MGZL are available, primarily due to its recent identification, rarity, and challenges in diagnosis. Although recent several studies have suggested dose-adjusted EPOCH-R (etoposide, doxorubicin, vincristine, cyclophosphamide, prednisolone, and rituximab) may improve outcomes in patients with MGZL, numerous patients still suffer from relapsed/refractory MGZL, and the optimal management for such patients remains uncertain...
May 21, 2018: International Journal of Hematology
https://www.readbyqxmd.com/read/29779395/training-the-next-generation-of-hiv-providers-impact-of-trainees-on-patient-satisfaction-in-an-urban-hiv-clinic
#2
Jacqueline E Sherbuk, Lydia Aoun Barakat
For persons living with HIV and AIDS (PLWHA), care by an HIV-specialist improves outcomes and satisfaction with one's HIV primary care provider (PCP) promotes engagement with care. In the United States, we are facing a workforce shortage of HIV providers. As we aim to train a new generation of HIV providers, it is unclear how PLWHA perceive their experience when cared for by trainees compared to experienced providers. Therefore we assessed patient satisfaction with HIV providers, both trainees in an HIV Primary Care residency program and HIV-specialists...
May 21, 2018: AIDS Care
https://www.readbyqxmd.com/read/29754480/pycnogenol%C3%A2-supplementation-in-minimal-cognitive-dysfunction
#3
Morio Hosoi, Gianni Belcaro, Aristide Saggino, Roberta Luzzi, Mark Dugall, Beatrice Feragalli
BACKGROUND: Impairments in cognitive function are difficult to evaluate and measure. In most cases, subjects do not perceive any alteration in their own status, particularly in case of mild cognitive impairment. In case of minimal alterations of cognitive function, no real treatment exists at the moment. Functional and/or temporary alterations in the cerebral microcirculation may be involved in cognitive impairment, and some aspects of MCI may be theoretically caused by perfusional problems...
June 2018: Journal of Neurosurgical Sciences
https://www.readbyqxmd.com/read/29742660/management-of-labor-and-delivery-after-fetoscopic-repair-of-an-open-neural-tube-defect
#4
Jaden R Kohn, Vibha Rao, Allison A Sellner, Dina Sharhan, Jimmy Espinoza, Alireza A Shamshirsaz, William E Whitehead, Michael A Belfort, Magdalena Sanz Cortes
OBJECTIVE: To report labor, delivery, and neonatal outcomes in a cohort of women delivering neonates who had undergone fetoscopic neural tube defect repair. METHODS: We conducted a retrospective cohort study from April 2014 to January 2018. All patients met Management of Myelomeningocele Study eligibility criteria. We included patients with completed second-trimester fetoscopic neural tube defect repair (laparotomy, uterine exteriorization, and minimally invasive access through two or three uterine ports) followed by standardized management of labor and delivery at our institution...
May 7, 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29737149/temporary-kidney-dysfunction-robuvit%C3%A2-supplementation-in-initial-transient-kidney-insufficiency-and-micro-macro-albuminuria
#5
Andrea Ledda, Gianni Belcaro, Beatrice Feragalli, Morio Hosoi, Marisa Cacchio, Roberta Luzzi, Mark Dugall, Roberto Cotellese, Maria R Cesarone
BACKGROUND: The aim of this study was to evaluate the efficacy of Robuvit® (French oak extract, Horphag Research) in improving kidney function in subjects with temporary kidney dysfunction (TKD) and increased oxidative stress levels. METHODS: Fifty-seven subjects with TKD were included in the registry. Subjects were divided into two goups according to albumin levels in the urine. Plasma free radicals were measured in order to evaluate a possible connection with alterations in kidney function...
June 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29736695/severe-asthma-challenges-and-pitfalls-in-management
#6
REVIEW
Anirban Maitra
A small but significant subset of asthmatic children show a lack of response to standard management, resulting in further intensification of therapy to optimise symptom control and may remain symptomatic despite maximal therapy. Severe asthma results in increased risk of adverse outcomes whilst contributing significantly to the economic burden on the nation's health resources. The ERS / ATS guidelines were published in 2014 and form the basis of identifying, evaluating and managing severe asthmatic children...
May 7, 2018: Indian Journal of Pediatrics
https://www.readbyqxmd.com/read/29733804/bilateral-dislocation-of-the-temporomandibular-joint-in-children
#7
REVIEW
Ludovic Sicard, Diane O'Hana, Roman Hossein Khonsari, Abdelkhaled Kaddour Brahim
PURPOSE: Bilateral nontraumatic temporomandibular joint (TMJ) dislocation is an acute situation that can lead to a chronic and recurrent condition. Few pediatric cases have been reported in the literature and no standardized care protocol has been established to date. MATERIALS AND METHODS: Two cases of chronic bilateral dislocation of the TMJ in young children are reported and their medical management is discussed based on data from the literature. RESULTS: ▪▪▪...
April 11, 2018: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/29730601/early-application-of-haemostatic-powder-added-to-standard-management-for-oesophagogastric-variceal-bleeding-a-randomised-trial
#8
Mostafa Ibrahim, Ahmed El-Mikkawy, Mohamed Abdel Hamid, Haitham Abdalla, Arnaud Lemmers, Ibrahim Mostafa, Jacques Devière
BACKGROUND: Acute variceal bleeding (AVB) requires early therapeutic management by experienced endoscopists that often poses logistical challenges for hospitals. We assessed a different management concept with early application of haemostatic powder-which does not require high endoscopic expertise-added to conventional management in a randomised trial. METHODS: Cirrhotic patients with AVB received standard medical therapy and were randomised to either immediate endoscopy with haemostatic powder application within 2 hours of admission, followed by early elective endoscopy on the next day, that is, within 12-24 hours of admission for definitive treatment (study group) or to early elective endoscopy only (control group)...
May 5, 2018: Gut
https://www.readbyqxmd.com/read/29724749/emollient-bath-additives-for-the-treatment-of-childhood-eczema-bathe-multicentre-pragmatic-parallel-group-randomised-controlled-trial-of-clinical-and-cost-effectiveness
#9
Miriam Santer, Matthew J Ridd, Nick A Francis, Beth Stuart, Kate Rumsby, Maria Chorozoglou, Taeko Becque, Amanda Roberts, Lyn Liddiard, Claire Nollett, Julie Hooper, Martina Prude, Wendy Wood, Kim S Thomas, Emma Thomas-Jones, Hywel C Williams, Paul Little
OBJECTIVES: To determine the clinical effectiveness and cost effectiveness of including emollient bath additives in the management of eczema in children. DESIGN: Pragmatic randomised open label superiority trial with two parallel groups. SETTING: 96 general practices in Wales and western and southern England. PARTICIPANTS: 483 children aged 1 to 11 years, fulfilling UK diagnostic criteria for atopic dermatitis. Children with very mild eczema and children who bathed less than once weekly were excluded...
May 3, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29719945/robuvit%C3%A2-improvement-of-fatigue-in-medical-convalescence
#10
Edmondo Ippolito, Gianni Belcaro, Roberta Luzzi, Morio Hosoi, Mark Dugall, Peter Rohdewald, Beatrice Feragalli, Roberto Cotellese, Paula Peterzan
BACKGROUND: The aim of this registry study was the evaluation of symptoms of fatigue following supplementation with an oak wood extract (Robuvit®) after disappearance of acute symptoms. Robuvit®, with established antioxidant-antifatigue activity, has been successfully used in hepatic failure and in chronic fatigue syndrome: these conditions are characterized by weakness and fatigue and are broadly comparable to convalescence that is associated to increased oxidative stress. METHODS: The registry study lasted 3 weeks...
May 2018: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/29718346/two-years-of-bicalutamide-monotherapy-in-patients-with-biochemical-relapse-after-radical-prostatectomy
#11
Teppei Okubo, Koji Mitsuzuka, Takuya Koie, Senji Hoshi, Shigeki Matsuo, Seiichi Saito, Norihiko Tsuchiya, Tomonori Habuchi, Chikara Ohyama, Yoichi Arai
Background: Salvage treatments for biochemical relapse (BCR) after radical prostatectomy (RP) have several problems in terms of indications or adverse events. We studied the possibility of 2 years of bicalutamide monotherapy for BCR after RP. Methods: Patients who showed BCR (prostate-specific antigen (PSA) ≥ 0.2 ng/ml) after RP were recruited. Protocol treatment was planned as 2 years of bicalutamide (80 mg/day) followed by observation. Protocol treatment failure was defined as PSA re-elevation of ≥0...
April 28, 2018: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29708930/management-of-chronic-complications-associated-with-herpes-zoster-ophthalmicus
#12
Saujanya Vadoothker, Bennie H Jeng
PURPOSE OF REVIEW: Herpes zoster ophthalmicus (HZO) has the potential to cause significant visual morbidity and functional disability in patients with recalcitrant disease, keratitis, and postherpetic neuralgia. This article will review the current methods of prevention and treatment of anterior segment-related chronic complications of HZO. RECENT FINDINGS: HZO-related anterior segment ocular complications can range to include conjunctivitis, keratitis, and uveitis that can all be difficult to manage...
April 27, 2018: Current Opinion in Ophthalmology
https://www.readbyqxmd.com/read/29707350/treatment-choice-by-patients-with-obstructive-sleep-apnea-data-from-two-centers-in-china
#13
Wen-Jing Liao, Li-Juan Song, Hong-Liang Yi, Jian Guan, Jian-Yin Zou, Hua-Jun Xu, Gang Wang, Fei Ma, Li-Bo Zhou, Yu-Qing Chen, Li-Bo Yan, Zhi-Cheng Deng, Walter T McNicholas, Shan-Kai Yin, Nan-Shan Zhong, Xiao-Wen Zhang
Background: Standard management has been recommended for obstructive sleep apnea (OSA) by several guidelines, but patient choice in the practical setting is unclear. Methods: A survey nested in two prospective cohort studies of OSA (enrollment: 2001-2010) in China. The last interview was conducted between July 2014 and May 2015, using a comprehensive 10-point questionnaire administered in a face-to-face or telephone interview, and assessed (I) whether the participant had received any OSA treatment; (II) why he or she had decided for or against treatment; (III) what treatment was received; (IV) whether the participant used continuous positive airway pressure (CPAP) or OA daily; and (V) the perceived efficacy of therapy...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29699027/-management-programs-on-diabetes-among-chinese-adults-in-the-national-demonstration-areas-for-comprehensive-prevention-and-control-of-non-communicable-diseases
#14
R R Jin, J J Li, J Zhang, J L Li, F Bian, G J Deng, S Ma, X W Su, J Zhao, Y Jiang
Objective: To understand the current situation on management of diabetes mellitus patients aged 35 and above in the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases, in China. Methods: Local residents, aged 18 years and above were randomly selected by a complex, multistage, probability sampling method. Face-to-face questionnaire survey was carried out between November and December 2016. Rates regarding prevalence, treatment and management of diabetes were calculated, and influencing factors of diabetes were analyzed by using the non-conditional logistic regression model...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29699026/-current-status-on-prevalence-treatment-and-management-of-hypertension-among-chinese-adults-in-the-national-demonstration-areas-for-comprehensive-prevention-and-control-of-non-communicable-diseases
#15
R R Jin, J Zhang, J L Li, J J Li, S Ma, F Bian, G J Deng, X W Su, Z Z Shen, Y P Wang, Y Jiang
Objective: To investigate the current status of prevalence, treatment, and management on hypertension among Chinese adults from the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases. Methods: We selected a total of 4 000 residents aged ≥18 years for this questionnaire-based survey by multi-stage clustering sampling in 10 National Demonstration Areas between November and December, 2016. Results: There were 3 891 effective questionnaires. The self-reported prevalence of hypertension among aged ≥35 years was 31...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29699025/-study-on-the-effectiveness-of-implementation-the-national-demonstration-areas-for-comprehensive-prevention-and-control-of-non-communicable-diseases
#16
J Zhang, R R Jin, J J Li, J L Li, X W Su, G J Deng, S Ma, J Zhao, Y P Wang, F Bian, Y M Qu, Z Z Shen, Y Jiang, Y L Liu
Objective: To assess the implementation and impact of programs carried out by the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases. Methods: Both sociological and epidemiological methods were used to collect qualitative and quantitative data in November and December, 2016 in order to conduct on process and outcome evaluation of the above mentioned objective. In the meantime, case study was also conducted. Results: All the National Demonstration Areas for Comprehensive Prevention and Control of Non-communicable Diseases were found well implemented across the country, with health education and health promotion, surveillance and safeguard measures in particular...
April 10, 2018: Zhonghua Liu Xing Bing Xue za Zhi, Zhonghua Liuxingbingxue Zazhi
https://www.readbyqxmd.com/read/29686909/spontaneous-bacterial-peritonitis-due-to-lactobacillus-paracasei-in-cirrhosis
#17
Emily Harding-Theobald, Bharat Maraj
Lactobacillus species colonize the human gastrointestinal tract and are rarely pathogenic. We present a case involving a cirrhotic patient who presented with sepsis and was found to have peritoneal cultures demonstrating Lactobacillus as the sole pathogen concerning for spontaneous bacterial peritonitis. Treatment was achieved with high-dose penicillin and clindamycin but the patient developed hepatorenal syndrome and died from acute renal failure. Intra-abdominal Lactobacillus infections are typically seen in patients undergoing peritoneal dialysis or who have recently had bowel perforation...
2018: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/29679134/aphallia-a-review-to-standardize-management
#18
REVIEW
Tarryn Gabler, Robyn Charlton, Jerome Loveland, Ellen Mapunda
Congenital aphallia is a rare anomaly with little supporting literature and controversial management. The aim of this review is to assess the most recent literature with a focus on staged management of these cases. We performed a PubMed search of all English literature in the past 10 years using the term aphallia. Twenty-three articles were identified of which six were excluded. A further three papers meeting our criteria were found in the references to papers initially identified. We found that management can be staged in three phases: short, intermediate and long-term...
April 20, 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29670801/nonoperative-management-of-multiple-penetrating-cardiac-and-colon-wounds-from-a-shotgun-a-case-report-and-literature-review
#19
Paula M Jaramillo, Jaime A Montoya, David A Mejia, Salin Pereira Warr
Introduction: Surgery for cardiac trauma is considered fatal and for wounds of the colon by associated sepsis is normally considered; however, conservative management of many traumatic lesions of different injured organs has progressed over the years. Presentation of the Case: A 65-year-old male patient presented with multiple shotgun wounds on the left upper limb, thorax, and abdomen. On evaluation, he was hemodynamically stable with normal sinus rhythm and normal blood pressure, no dyspnea, or abdominal pain...
2018: Case Reports in Surgery
https://www.readbyqxmd.com/read/29669438/standardized-management-protocol-in-severe-postpartum-hemorrhage-a-single-center-study
#20
Giuseppe Colucci, Karin Helsing, Franziska Demarmels Biasiutti, Luigi Raio, Pirmin Schmid, Dimitrios A Tsakiris, Balthasar Eberle, Daniel Surbek, Bernhard Lämmle, Lorenzo Alberio
Severe postpartum hemorrhage (sPPH) is an obstetric emergency that needs prompt and effective therapy to reduce the risk of complications. In this study, women who developed sPPH (study cohort, n = 27) were treated according to a standardized management protocol prescribing sequential administration of uterotonic drugs, crystalloids, tranexamic acid, labile blood products, low-dose fibrinogen, and recombinant activated factor VII (rFVIIa). This group was compared to patients treated with different strategies during 2 preceding periods: an in-house guideline regulating the administration of rFVIIa (historical cohort 1, n = 20) and no specific guideline (historical cohort 2, n = 27)...
January 1, 2018: Clinical and Applied Thrombosis/hemostasis
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