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Esophageal atresia

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https://www.readbyqxmd.com/read/29750630/esophageal-atresia-with-tracheoesophageal-fistula-and-gastroesophageal-reflux-in-children-dental-considerations-and-case-report
#1
J Arturo Garrocho-Rangel, Juana M Arvizu-Rivera, Nadia P Campos-Lara, Miguel A Rosales-Berber, Amaury Pozos-Guillén
BACKGROUND: Esophageal Atresia (EA) is defined as the congenital interruption of the continuity of the esophagus. Pediatric patients also have other congenital conditions, such as Tracheo-Esophageal Fistula (TEF). CASE REPORT: A 7-year-old male with TEF referred by a Pediatric Cardiologist, with the principal complaint of "severe and generalized tooth wearing". Considering that the patient was systemically stable, it was decided to perform the oral procedures under local anesthesia and rubber-dam isolation with an antimicrobial prophylaxis regimen...
May 11, 2018: Journal of Clinical Pediatric Dentistry
https://www.readbyqxmd.com/read/29740616/anastomotic-strictures-after-esophageal-atresia-repair-timing-of-dilatation-during-the-first-two-postoperative-years
#2
Martin Salö, Pernilla Stenström, Magnus Anderberg, Einar Arnbjörnsson
Background  We determined time frames for dilatation of anastomotic strictures (ASs) occurring during the first 2 years after esophageal atresia (EA) repair. Methods  A retrospective study was conducted on children with EA (Gross type C) who underwent direct repair between January 2008 and March 2015 at a single tertiary center of pediatric surgery. Endoscopic signs of stricture were indications for dilatation because the endoscopy provides more reliable information than X-ray imagining methods. Results  Among our cohort of 49 children with EA, 19 (39%) required at least one esophageal dilatation...
April 2018: Surgery Journal
https://www.readbyqxmd.com/read/29739032/management-and-outcome-of-neonates-with-a-prenatal-diagnosis-of-esophageal-atresia-type-a-a-population-based-study
#3
C Garabedian, A Bonnard, V Rousseau, R Sfeir, S Blanc, J Boubnova, C Jacquier, S Irtan, A Breton, V Fouquet, A Guinot, T Lamireau, E Habonimana, A Schneider, F Elbaz, A Ranke, M L Poli-Merol, N Kalfa, T Petit, J-L Michel, P Buisson, J Lirussi-Borgnon, H Lardy, B Parmentier, C Cremillieux, F Schmitt, C Borderon, O Jaby, C Pelatan, P De Vries, M Pouzac-Arnould, C Grosos, J Breaud, C Tolg, Y Chaussy, C Laplace, E E Drumez, L Michaud, F Gottrand, V Houfflin-Debarge
OBJECTIVE: Evaluate the neonatal management and outcomes of neonates with prenatal diagnosis of esophageal atresia EA type A. METHODS: This population-based study was conducted using data from the French National Register for Infants with EA born from 2008 to 2014, including all cases of EA type A. We compared prenatal and neonatal characteristics and outcomes in children with prenatal diagnosis of EA type A to those with a postnatal diagnosis until the age of one...
May 8, 2018: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29738345/the-esophageal-atresia-quality-of-life-questionnaires-feasibility-validity-and-reliability-in-sweden-and-germany
#4
Michaela Dellenmark-Blom, Jens Dingemann, Stefanie Witt, Julia H Quitmann, Linus Jönsson, Vladimir Gatzinsky, John E Chaplin, Monika Bullinger, Sofie Flieder, Benno M Ure, Carmen Dingemann, Kate Abrahamsson
OBJECTIVES: Esophageal atresia (EA) is a rare malformation characterized of discontinuity of the esophagus, concurrent with or without a tracheoesophageal fistula (TEF). We report the validity and reliability of a condition-specific quality of life (QOL) tool for EA/TEF children, the age-adapted EA-QOL-questionnaires, when used in Sweden and Germany. METHODS: 124 families of children with EA/TEF participated in the study; 53 parents completed the EA-QOL-questionnaire for children aged 2-7 years; 62 children/71 parents the EA-QOL-questionnaire for children 8-17 years...
May 5, 2018: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29733490/the-efficacy-of-serum-brain-natriuretic-peptide-for-the-early-detection-of-portopulmonary-hypertension-in-biliary-atresia-patients-before-liver-transplantation
#5
Koichiro Yoshimaru, Toshiharu Matsuura, Yoshiaki Takahashi, Yusuke Yanagi, Hazumu Nagata, Shouichi Ohga, Tomoaki Taguchi
Severe portopulmonary hypertension (POPH) is a contraindication for liver transplantation (LT) because of the high risk of postoperative heart failure. The early detection of POPH is important for patients with biliary atresia (BA). Brain natriuretic peptide (BNP) is known to be correlated with liver fibrosis in patients with liver cirrhosis. The aim of this study was to elucidate the efficacy of BNP measurement for the follow-up of patients with BA. Thirty-two patients with BA were identified from September 2011 to December 2016...
May 7, 2018: Pediatric Transplantation
https://www.readbyqxmd.com/read/29732364/impaired-fgf10-signaling-and-epithelial-development-in-experimental-lung-hypoplasia-with-esophageal-atresia
#6
Jun Wang, Hao Liu, Linlin Gao, Xiaomei Liu
Patients with esophageal atresia (EA) and tracheoesophageal fistula (TEF) often experience persistent respiratory tract disease. In experimental models, doxorubicin-induced developmental lung abnormalities may result from downregulation of branching morphogenesis factor fibroblast growth factor (Fgf10). This study investigated the temporospatial expression of Fgf10 pathway components and lung epithelial factors in an doxorubicin-induced EA-TEF model by quantitative polymerase chain reaction, immunohistochemistry, and immunoblotting...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29720579/congenital-esophageal-atresia-and-microtia-in-a-newborn-secondary-to-mycophenolate-mofetil-exposure-during-pregnancy-a-case-report-and-review-of-the-literature
#7
Musaed Mohammed Alsebayel, Faisal Abdulrahman Abaalkhail, Faisal Mohammed Alsebayel, Dema A Alissa, Ahmed Hamdan Al-Jedai, Hussien Elsiesy
BACKGROUND Mycophenolate mofetil (MMF) is one of the most commonly prescribed drugs to prevent organ transplant rejection in combination with calcineurin inhibitors and steroids. It has a different toxicity profile than tacrolimus and cyclosporine.  Gastrointestinal tract disturbances are the most common adverse effects. The use of MMF in pregnant women, however, holds great risk of miscarriage and fetal development defects such as external ear malformation, ocular anomalies, cleft lip and palate, and abnormality of distal limbs, heart, esophagus, and kidneys...
May 3, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29715697/epidemiology-and-outcome-of-major-congenital-malformations-in-a-large-german-county
#8
Boris Wittekindt, Rolf Schloesser, Nora Doberschuetz, Emilia Salzmann-Manrique, Jasmin Grossmann, Bjoern Misselwitz, Udo Rolle
INTRODUCTION:  Congenital malformations are associated with substantial neonatal morbidity and mortality. Furthermore, only sparse data are available on the modalities of care provided to and the associated clinical outcomes in affected neonates. In this study, we focused on five malformations that require surgery during the neonatal period: duodenal stenosis and atresia (DA), gastroschisis (GA), omphalocele (OM), congenital diaphragmatic herniation (CDH), and esophageal atresia (EA)...
May 1, 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29703801/successful-management-of-chylothorax-with-etilefrine-case-report-in-2-pediatric-patients
#9
Gysella Muniz, Jennifer Hidalgo-Campos, Maria Del Carmen Valdivia-Tapia, Nader Shaikh, Nilton Yhuri Carreazo
Chylothorax is defined as the accumulation of chyle within the pleural space. Originally described in 1917 by Pisek, it is the most common cause of pleural effusion in the neonatal period. The leading cause of chylothorax is laceration of the thoracic duct during surgery, which occurs in 0.85% to 6.6% of children undergoing cardiothoracic surgery. Few authors of reports in the literature have looked at etilefrine, a relatively unknown sympathomimetic, as an option for the medical treatment of chylothorax. In this case report, we review the clinical course of 2 infants with type III esophageal atresia who developed chylothorax after thoracic surgery and were successfully treated with intravenous etilefrine after failing initial dietary and pharmacological management...
April 27, 2018: Pediatrics
https://www.readbyqxmd.com/read/29681702/kluth-type-iiib-6-esophageal-atresia-diagnostic-dilemma-and-pitfalls-of-using-infant-feeding-tube
#10
Rahul Gupta, Pramila Sharma, Ram Babu Goyal
We describe three male neonates where infant feeding tube (IFT) passed 18-20 cm in the upper esophageal pouch. A blunt-tipped red rubber catheter confirmed esophageal atresia (EA) with long upper pouch in all three cases. Definitive management revealed EA with tracheoesophageal fistula and long overlapping upper esophageal pouch consistent with Kluth Type IIIb6 variant in two patients. Importance of using red rubber catheter at the pediatric practice instead of IFT is stressed.
April 2018: Journal of Indian Association of Pediatric Surgeons
https://www.readbyqxmd.com/read/29670869/pathogenetic-and-prognostic-factors-for-neonatal-gastric-perforation-personal-experience-and-systematic-review-of-the-literature
#11
Chiara Iacusso, Alessandro Boscarelli, Fabio Fusaro, Pietro Bagolan, Francesco Morini
Introduction: Neonatal gastric perforation (NGP) is a rare entity. Our aim was to report our experience and review the recent literature to characterize NGP, describe associated factors, and define prognostic factors. Materials and methods: Retrospective review of all consecutive patients with NGP treated between June 2009 and December 2017 in a third level pediatric hospital. In addition, a systematic review of Medline and Scopus database was performed using a defined strategy...
2018: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/29628411/impact-of-esophageal-atresia-on-the-success-of-fundoplication-for-gastroesophageal-reflux
#12
Samantha A Pellegrino, Sebastian K King, Elizabeth McLeod, Alisa Hawley, Jo-Anne Brooks, John M Hutson, Warwick J Teague
OBJECTIVES: Fundoplication is commonly performed in patients with a history of esophageal atresia (EA), however, the success of this surgery is reduced, as reflected by an increased rate of redo fundoplication. We aimed to determine whether EA impacts the prevalence of fundoplication, its timing, and performance of a redo operation. STUDY DESIGN: A single-center, retrospective review of all patients undergoing fundoplication over a 20-year period (1994-2013) was performed...
April 5, 2018: Journal of Pediatrics
https://www.readbyqxmd.com/read/29622396/the-distended-fetal-hypopharynx-a-sensitive-and-novel-sign-for-the-prenatal-diagnosis-of-esophageal-atresia
#13
Sarah Tracy, Terry L Buchmiller, Offir Ben-Ishay, Carol E Barnewolt, Susan A Connolly, David Zurakowski, Andrew Phelps, Judy A Estroff
BACKGROUND/PURPOSE: Although advances have been made in the prenatal diagnosis of esophageal atresia (EA), most neonates are not identified until after birth. The distended hypopharynx (DHP) has been suggested as a novel prenatal sign for EA. We assess its diagnostic accuracy and predictive value on ultrasound (US) and magnetic resonance imaging (MRI), both alone and in combination with the esophageal pouch (EP) and secondary signs of EA (polyhydramnios and a small or absent fetal stomach)...
March 7, 2018: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29621589/identification-of-rare-heterozygous-missense-mutations-in-fanca-in-esophageal-atresia-patients-using-next-generation-sequencing
#14
Yu Feng, Runsen Chen, Min Da, Bo Qian, Xuming Mo
Esophageal atresia and tracheoesophageal fistula (EA/TEF) are relatively common malformations in newborns, but the etiology of EA/TEF remains unknown. Fanconi anemia (FA) complementation group A (FANCA) is a key component of the FA core complex and is essential for the activation of the DNA repair pathway. The middle region (amino acids 674-1208) of FANCA is required for its interaction with FAAP20. We performed targeted sequencing of this binding region of FANCA (exons 23-36) in 40 EA/TEF patients. We also investigated the effect of the p...
April 2, 2018: Gene
https://www.readbyqxmd.com/read/29614258/the-visionaries-the-virtuosos-and-the-history-of-congenital-esophageal-atresia-surgery
#15
Magdalena Mazurak, Dariusz Patkowski
The year 2018 marks the 130th anniversary of the first known surgical attempt at correction of esophageal atresia performed by Charles Steele. But before the first successful procedure happened many other surgeons undertook heroic attempts to save newborns and infants with this defect. 271 years have passed from the first description of the defect to the first surgery survivor. The paper presents a fascinating history of these milestones in pediatric surgery and its pioneers, whose creativity, mastery and phantasy created a basis of congenital esophageal atresia surgery...
March 31, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29536176/are-prophylactic-anti-reflux-medications-effective-after-esophageal-atresia-repair-systematic-review-and-meta-analysis
#16
REVIEW
Hiromu Miyake, Yong Chen, Alison Hock, Shogo Seo, Yuhki Koike, Agostino Pierro
PURPOSE: Gastroesophageal reflux after surgical repair of esophageal atresia (EA) can be associated with complications, such as esophageal stricture. Recent guidelines recommend prophylactic anti-reflux medication (PARM) after EA repair. However, the effectiveness of PARM is still unclear. The aim of this study was to review evidence surrounding the use of PARM in children operated for EA. METHODS: We performed a systematic review and meta-analysis. We searched Medline, EMBASE, and the Cochrane Databases from inception until the end of 2016 for comparative studies of PARM versus no PARM (control)...
May 2018: Pediatric Surgery International
https://www.readbyqxmd.com/read/29534254/perioperative-complications-of-esophageal-atresia
#17
REVIEW
Francesco Morini, Andrea Conforti, Pietro Bagolan
Current survival rate of infants with esophageal atresia with/without tracheoesophageal fistula (EA/TEF) exceeds 90% and great interest is dedicated to the long-term outcomes and complications. However, perioperative complications represent a significant burden to the EA/TEF infants and a technical challenge for the surgeon. In this review, we will focus on the most frequent perioperative complications specific of EA/TEF to describe their predisposing factors, possible preventive measures, and treatment options...
April 2018: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/29531469/four-cancer-cases-after-esophageal-atresia-repair-time-to-start-screening-the-upper-gastrointestinal-tract
#18
Floor Wt Vergouwe, Madeleine Gottrand, Bas Pl Wijnhoven, Hanneke IJsselstijn, Guillaume Piessen, Marco J Bruno, René Mh Wijnen, Manon Cw Spaander
Esophageal atresia (EA) is one of the most common congenital digestive malformations and requires surgical correction early in life. Dedicated centers have reported survival rates up to 95%. The most frequent comorbidities after EA repair are dysphagia (72%) and gastroesophageal reflux (GER) (67%). Chronic GER after EA repair might lead to mucosal damage, esophageal stricturing, Barrett's esophagus and eventually esophageal adenocarcinoma. Several long-term follow-up studies found an increased risk of Barrett's esophagus and esophageal carcinoma in EA patients, both at a relatively young age...
March 7, 2018: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/29527854/infants-born-with-esophageal-atresia-with-or-without-tracheo-esophageal-fistula-short-and-long-term-outcomes
#19
Leah Leibovitch, Iris Zohar, Ayala Maayan-Mazger, Ram Mazkereth, Tzipora Strauss, Ron Bilik
BACKGROUND: The estimated incidence of esophageal atresia (EA) with or without tracheo-esophageal fistula (TEF) is 1:3500 live births. During childhood these patients have various co-morbidities, but the overall quality of life among adults is similar to that of the general population. OBJECTIVES: To evaluate short- and long-term co-morbidities and quality of life among infants born with EA ± TEF at a large single medical center. METHODS: Medical records of 65 children born over a 21 year period were reviewed for short- and long-term medical data...
March 2018: Israel Medical Association Journal: IMAJ
https://www.readbyqxmd.com/read/29519575/oral-feeding-outcomes-in-infants-with-esophageal-atresia-and-tracheoesophageal-fistula
#20
Mackenzie C Lees, Ioana Bratu, Maryna Yaskina, Michael van Manen
PURPOSE: The purpose of this study was to explore oral feeding outcomes in infants born with type-C esophageal atresia and tracheoesophageal fistula (EA/TEF). METHODS: A retrospective cohort study of all infants born between January 2005 and December 2015 undergoing surgery for type-C EA/TEF at the University of Alberta Hospital was performed. RESULTS: Fifty-seven infants were identified, of which 61.4% were exclusively orally feeding at discharge home...
May 2018: Journal of Pediatric Surgery
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