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Esophageal atresia

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https://www.readbyqxmd.com/read/28920017/esophageal-atresia-with-tracheo-esophageal-fistula-presenting-beyond-7-days
#1
Nilesh Nagdeve, Mohini Sukhdeve, Tushar Thakre, Suresh Morey
AIM: To describe our experience of neonates with esophageal atresia with tracheo-esophageal fistula (EA with TEF) who presented after a week. DESIGN: Retrospective study of the patients of EA with TEF who presented after a week. STUDY SETTING: Department of Pediatric Surgery, Government Medical College Nagpur. Study Duration: Eight years. MATERIALS AND METHODS: Demographic information, hematological, biochemical and radiological data were obtained from the patients' medical records...
July 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28914345/comparison-of-clinical-outcomes-between-open-and-thoracoscopic-repair-for-esophageal-atresia-with-tracheoesophageal-fistula-a-systematic-review-and-meta-analysis
#2
Yuhao Wu, Hongyu Kuang, Tiewei Lv, Chun Wu
OBJECTIVE: A meta-analysis was performed for a comparison of outcomes between open repair (OR) and thoracoscopic repair (TR) for esophageal atresia with tracheoesophageal fistula (EA with TEF). METHODS: Electronic databases, including PubMed, Cochrane Library, and Medline, were searched systematically for the literatures aimed mainly at comparing the therapeutic effects for EA with TEF administrated by OR and TR. Corresponding data sets were extracted and two reviewers independently assessed the methodological quality...
September 15, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28878607/genetic-testing-in-a-cohort-of-complex-esophageal-atresia
#3
Eliane Beauregard-Lacroix, Jessica Tardif, Emmanuelle Lemyre, Zoha Kibar, Christophe Faure, Philippe M Campeau
The objective of the present study is to describe a cohort of complex esophageal atresia and the yield of genetic tests performed for such patients. We selected 45 patients with complex esophageal atresia (EA), namely those having at least one associated anomaly. We reviewed their medical records to assess clinical features, other diagnoses, and genetic investigations. Most of the patients had a diagnosis of VACTERL association (56%) with no genetic variant identified. Interestingly, 5 patients in the cohort (11%) had a right pulmonary hypoplasia or agenesis...
August 2017: Molecular Syndromology
https://www.readbyqxmd.com/read/28877681/fibronectin-glomerulopathy-complicated-with-persistent-cloaca-and-congenital-esophageal-atresia-a-case-report-and-literature-review
#4
Misaki Takii, Takaichi Suehiro, Aya Shima, Hideki Yotsueda, Satoshi Hisano, Ritsuko Katafuchi
BACKGROUND: Fibronectin glomerulopathy is a rare, inherited, autosomal dominant, glomerular disease characterized by proteinuria, microscopic hematuria, hypertension, massive glomerular deposits of fibronectin, and slow progression to end-stage renal failure. Because the incident of fibronectin glomerulopathy is extremely low, the pathophysiology, genetic abnormalities, epidemiology, and mechanisms remain to be elucidated. CASE PRESENTATION: We report a 21-year-old woman with fibronectin glomerulopathy, who had been diagnosed with persistent cloaca and congenital esophageal atresia at birth...
September 6, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28877007/creation-of-an-esophageal-atresia-animal-model-using-a-bifurcated-esophagus-to-maintain-digestive-tract-continuity
#5
Ian C Glenn, Nicholas E Bruns, Steve J Schomisch, Todd A Ponsky
INTRODUCTION: We previously developed a porcine model of long gap pure esophageal atresia (EA) to aid in the creation of novel devices and techniques for treatment of EA. Shortcomings of the model included difficulty decompressing the proximal esophageal pouch (leading to recurrent aspiration) and a requirement for gastrostomy tube (G-tube) feeds. Therefore, we sought to create a porcine model with a bifurcated esophagus wherein one portion of the esophageal lumen retained patency and the other part mimicked EA...
September 6, 2017: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/28873491/no-tissue-expression-of-kras-or-braf-mutations-in-61-adult-patients-treated-for-esophageal-atresia-in-early-childhood
#6
Kien Xuan Dang, Tho Ho, Saara Sistonen, Antti Koivusalo, Mikko Pakarinen, Risto Rintala, Ulf-Hakan Stenman, Arto Orpana, Jakob Stenman
No abstract text is available yet for this article.
September 5, 2017: European Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28870218/respiratory-problems-in-children-with-esophageal-atresia-and-tracheoesophageal-fistula
#7
Federica Porcaro, Laura Valfré, Lelia Rotondi Aufiero, Luigi Dall'Oglio, Paola De Angelis, Alberto Villani, Pietro Bagolan, Sergio Bottero, Renato Cutrera
BACKGROUND: Children with congenital esophageal atresia (EA) and tracheoesophageal fistula (TEF) have chronic respiratory symptoms including recurrent pneumonia, wheezing and persistent cough. The aim of this study is to describe the clinical findings of a large group of children with EA and TEF surgically corrected and the instrumental investigation to which they have undergone in order to better understand the patient's needs and harmonize the care. METHODS: A retrospective data collection was performed on 105 children with EA and TEF followed at Department of Pediatric Medicine of Bambino Gesù Children's Hospital (Rome, Italy) between 2010 and 2015...
September 5, 2017: Italian Journal of Pediatrics
https://www.readbyqxmd.com/read/28859370/management-of-recurrent-tracheoesophageal-fistula-after-esophageal-atresia-and-follow-up
#8
J Wang, M Zhang, W Pan, W Wu, W Yan, W Cai
Recurrent tracheoesophageal fistula (rTEF) is a complex complication after the repair of esophageal atresia (EA) and remains a challenge because of difficulties in preoperative management and the substantial rates of mortality and morbidity after reoperation. By reviewing a single institution's experience in the management of rTEF and assessing the outcome, we aimed to provide an optimal approach for managing rTEF and to evaluate growth and feeding problems after reoperations. The medical records of 35 patients with rTEF treated at a single institution from June 2012 to December 2015 were reviewed, and follow-up data were collected from all survivors...
September 1, 2017: Diseases of the Esophagus: Official Journal of the International Society for Diseases of the Esophagus
https://www.readbyqxmd.com/read/28831606/changes-in-quality-of-life-from-infancy-to-school-age-after-esophagoesophagostomy-for-tracheoesophageal-fistula-thoracotomy-versus-thoracoscopy
#9
Go Miyano, Shogo Seo, Hiroki Nakamura, Ryo Sueyoshi, Manabu Okawada, Takashi Doi, Hiroyuki Koga, Geoffrey J Lane, Atsuyuki Yamataka
BACKGROUND: We assessed the quality of life (QOL) of postoperative esophageal atresia (EA) with tracheoesophageal fistula (TEF) cases, comparing open with thoracoscopic repair. METHODS: A retrospective review of consecutive EA/TEF repairs (2001-2014) was performed, excluding cases with birth weight less than 2000 g and severe cardiac/chromosomal anomalies. Of 37 cases, 13 had thoracoscopic repair (TR) and 24 had open repair (OR) according to the operating surgeon's preference...
August 22, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28807203/utilizing-stricture-indices-to-predict-dilation-of-strictures-after-esophageal-atresia-repair
#10
Rachel M Landisch, Sheila Foster, David Gregg, Thomas Chelius, Laura D Cassidy, Diana Lerner, Dave R Lal
BACKGROUND: Anastomotic stricture is the most common postoperative complication in infants undergoing repair of esophageal atresia with or without tracheoesophageal fistula (EA/TEF). Stricture indices (SIs) are used to predict infants at risk for stricture requiring dilation. We sought to determine the most accurate SI and optimal timing for predicting anastomotic dilation. MATERIALS AND METHODS: A retrospective study of infants undergoing repair of EA/TEF between 2008 and 2013 was performed...
August 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28803355/evaluation-of-developmental-prognosis-for-esophageal-atresia-with-tracheoesophageal-fistula
#11
Akiyoshi Nomura, Masaya Yamoto, Koji Fukumoto, Toshiaki Takahashi, Kei Ohyama, Akinori Sekioka, Yutaka Yamada, Naoto Urushihara
PURPOSE: This study investigated risk factors for developmental disorders after the repair of esophageal atresia with tracheoesophageal fistula (EA/TEF). METHODS: The clinical charts of all infants with EA/TEF (gross type C) treated at our institution between 1993 and 2013 were analyzed. Patients with chromosomal aberrations were excluded. Forty-seven patients were divided into groups according to the presence (D) or absence (N) of developmental disorders. Patients were assessed with appropriate developmental examinations at age >3 years...
August 12, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28801834/current-characteristics-and-management-of-congenital-esophageal-stenosis-40-consecutive-cases-from-a-multicenter-study-in-the-kyushu-area-of-japan
#12
Masaya Suzuhigashi, Tatsuru Kaji, Hiroyuki Noguchi, Mitsuru Muto, Michiko Goto, Motoi Mukai, Kazuhiko Nakame, Takafumi Kawano, Waka Yamada, Koji Yamada, Shun Onishi, Satoshi Ieiri
PURPOSE: Congenital esophageal stenosis (CES) is rare, and the available clinical data are limited. We explored the current diagnosis, treatment and outcomes of CES. METHODS: A questionnaire survey was performed using medical records at pediatric surgical centers in the Kyushu area. RESULTS: Over 10 years, 40 patients (24 males) had CES. The incidence of associated anomalies was 52.5% (21/40), and that of esophageal atresia was 20.0% (8/40)...
August 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28801747/comparison-of-outcomes-of-thoracoscopic-primary-repair-of-gross-type-c-esophageal-atresia-performed-by-qualified-and-non-qualified-surgeons
#13
Yujiro Tanaka, Takahisa Tainaka, Wataru Sumida, Chiyoe Shirota, Naruhiko Murase, Kazuo Oshima, Ryo Shirotsuki, Kosuke Chiba, Hiroo Uchida
PURPOSE: Although thoracoscopic repair of esophageal atresia has become widespread, most studies are based on operations performed by expert surgeons. Therefore, the outcomes of operations performed by non-expert surgeons are not well known. The aim of this study was to compare outcomes based on operator skill level. METHODS: We retrospectively reviewed the demographics and outcomes of patients with Gross type C esophageal atresia, who underwent primary thoracoscopic repair at our hospital between January 2014 and August 2016...
August 11, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28796065/a-scoring-system-to-predict-mortality-in-infants-with-esophageal-atresia-a-case-control-study
#14
Xiao-Wen Li, Ya-Jun Jiang, Xue-Qiu Wang, Jia-Lin Yu, Lu-Quan Li
Esophageal atresia (EA) is a rare anomaly that mandates surgical intervention. Patients with EA often have complicated medical courses due to both esophageal anomalies and related comorbidities. Although several prognostic classification systems have been developed to decrease the mortality rate in EA, most systems focus only on the influence of the major anomaly, and external risk factors that could be influenced by the neonatal caregivers to a certain extent are not included. The aim of this study was to investigate the risk factors for in-hospital mortality in neonates with EA and develop a scoring model to predict mortality...
August 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28782137/interkinetic-nuclear-migration-in-the-tracheal-and-esophageal-epithelia-of-the-mouse-embryo-possible-implications-for-tracheo-esophageal-anomalies
#15
Ryo Kaneda, Yuko Saeki, Dereje Getachew, Akihiro Matsumoto, Motohide Furuya, Noriko Ogawa, Tomoyuki Motoya, Ashiq Mahmood Rafiq, Esrat Jahan, Jun Udagawa, Ryuju Hashimoto, Hiroki Otani
Interkinetic nuclear migration (INM) is a cell polarity-based phenomenon in which progenitor cell nuclei migrate along the apico-basal axis of the pseudostratified epithelium in synchrony with the cell cycle. INM is suggested to be at least partially cytoskeleton-dependent and to regulate not only the proliferation/differentiation of stem/progenitor cells but also the localized/overall size and shape of organs/tissues. INM occurs in all three of the germ-layer derived epithelia, including the endoderm-derived gut...
August 6, 2017: Congenital Anomalies
https://www.readbyqxmd.com/read/28777465/basal-progenitor-cells-bridge-the-development-malignant-cancers-and-multiple-diseases-of-esophagus
#16
REVIEW
Baoshun Lin, Fuan Xie, Zhangwu Xiao, Xiaoqian Hong, Liming Tian, Kuancan Liu
The esophagus is a pivotal organ originating from anterior foregut that links the mouth and stomach. Moreover, its development involves precise regulation of multiple signal molecules and signal transduction pathways. After abnormal regulation of these molecules in the basal cells of the esophagus occurs, multiple diseases, including esophageal atresia with or without tracheoesophageal fistula, Barrett esophagus, gastroesophageal reflux, and eosinophilic esophagitis, will take place as a result. Furthermore, expression changes of signal molecules or signal pathways in basal cells and the microenvironment around basal cells both can initiate the switch of malignant transformation...
August 4, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/28774507/clinical-factors-associated-with-in-hospital-death-in-pediatric-surgical-patients-admitted-to-the-neonatal-intensive-care-unit-a-15-year-single-tertiary-center-experience
#17
Kohei Otake, Keiichi Uchida, Michiko Kubo, Akira Yamamoto, Yuka Nagano, Ryo Uratani, Kiyoshi Hashimoto, Kohei Matsushita, Mikihiro Inoue, Hirofumi Sawada, Masato Kusunoki
BACKGROUND/PURPOSE: The purpose of this study was to explore clinical characteristics and primary surgical diagnoses associated with in-hospital death in pediatric surgical patients admitted to the neonatal intensive care unit (NICU) of a tertiary hospital. METHODS: This retrospective study includes all patients admitted to our NICU for pediatric surgical diseases between January 2001 and December 2015. Univariate and multivariate binary logistic regression were performed to assess independent factors associated with in-hospital death...
July 15, 2017: Journal of Pediatric Surgery
https://www.readbyqxmd.com/read/28770141/type-iv-esophageal-atresia-with-nasogastric-tube-in-stomach
#18
Jose María Lloreda-García, Sandra Sevilla-Denia, Jose Luis Leante-Castellanos, Carmen Fuentes-Gutiérrez
No abstract text is available yet for this article.
April 2017: Journal of Neonatal Surgery
https://www.readbyqxmd.com/read/28756526/novel-use-of-porcine-extracellular-matrix-in-recurrent-stricture-following-repair-of-tracheoesophageal-fistula
#19
Sarah B Cairo, Benjamin Tabak, Carroll M Harmon, Kathryn D Bass
Anastomotic stricture is a common complication following repair of esophageal atresia (EA). Many factors are thought to contribute to stricture formation and a variety of management techniques have been developed. In this case report, we describe the treatment of a recurrent anastomotic stricture following repair of long-gap esophageal atresia. Porcine bladder extracellular matrix (ECM) was mounted on a stent and delivered endoscopically to the site of recurrent stricture. An appropriate positioning was confirmed using direct endoscopic visualization and intra-operative fluoroscopy...
July 29, 2017: Pediatric Surgery International
https://www.readbyqxmd.com/read/28753184/radiation-exposure-and-attributable-cancer-risk-in-patients-with-esophageal-atresia
#20
Yasmine Yousef, Robert Baird
OBJECTIVES: Cases of esophageal carcinoma have been documented in survivors of esophageal atresia (EA). Children with EA undergo considerable amounts of diagnostic imaging and consequent radiation exposure potentially increasing their lifetime cancer mortality risk. This study evaluates the radiological procedures performed on patients with EA and estimates their cumulative radiation exposure and attributable lifetime cancer mortality risk. METHODS: Medical records of patients with EA managed at a tertiary care center were reviewed for demographics, EA subtype and number and type of radiological investigations...
July 27, 2017: Journal of Pediatric Gastroenterology and Nutrition
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