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https://www.readbyqxmd.com/read/27917210/association-of-interleukin-17-angiotensin-ii-with-refractory-hypertension-risk-in-hemodialysis-patients
#1
Zebin Wang, Wei Shi, Xinling Liang, Wenjian Wang, Jianbo Liang
OBJECTIVE: The study was performed to investigate the association of interleukin 17 (IL 17) or angiotensin II (Ang II) with refractory hypertension risk in hemodialysis patients. METHODS: Ninety hemodialysis patients were enrolled into this study, and those with hypertension were divided into two groups. The Easy-to-Control Hypertension group (ECHG) had fifty patients, while the refractory hypertension group (RHG) had forty patients. Twenty healthy individuals were recruited as the control group...
September 2016: African Health Sciences
https://www.readbyqxmd.com/read/27893414/recombinant-haemonchus-contortus-24-kda-excretory-secretory-protein-rhces-24-modulate-the-immune-functions-of-goat-pbmcs-in-vitro
#2
Javaid Ali Gadahi, Baojie Li, Muhammad Ehsan, Shuai Wang, Zhenchao Zhang, Yujian Wang, Muhammad Waqqas Hasan, Ruofeng Yan, Xiaokai Song, Lixin Xu, Xiangrui Li
A 24 kDa protein is one of the important components in Haemonchus contortus (barber pole worm) excretory/secretory products (HcESPs), which was shown to have important antigenic function. However, little is known about the immunomodulatory effects of this proteinon host cell. In the present study gene encoding 24kDa excretory/secretory protein (HcES-24) was cloned. The recombinant protein of HcES-24 (rHcES-24) was expressed in a histidine-tagged fusion protein soluble form in Escherichia coli. Binding activity of rHcES-24 to goat PBMCs was confirmed by immunofluorescence assay (IFA) and its immunomudulatory effect on cytokine secretion, cell proliferation, cell migration and nitric oxide production were observed by co-incubation of rHcES-24...
November 21, 2016: Oncotarget
https://www.readbyqxmd.com/read/27887675/clinical-efficacy-and-safety-of-ixekizumab-for-treatment-of-psoriasis
#3
A Azevedo, T Torres
Psoriasis is a common, chronic, inflammatory skin disorder with a physical and emotional burden. Emerging evidence suggests that IL17-A is a key cytokine in the immunopathogenesis of psoriasis. Ixekizumab is a humanized IgG4 monoclonal antibody that acts by neutralizing IL-17A. Data from Phase I-III studies reveal that ixekizumab is highly effective in treating patients with moderate-to-severe plaque psoriasis. A large proportion of patients receiving ixekizumab achieved or maintained complete or near complete resolution of psoriatic lesions with an acceptable safety profile through week 60...
November 22, 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/27886802/advancements-in-the-management-of-uveitis
#4
REVIEW
Sergio Schwartzman
Uveitis may exist as a clinical manifestation of an underlying systemic disease or may represent an idiopathic entity, sometimes with a very characteristic pattern. Different forms of uveitis have been defined on the basis of three important variables: chronicity, anatomic location, and underlying etiology. The evolving understanding of the immune system has resulted in a more targeted approach to manage patients with different forms of uveitis, although clearly this approach is at a very early stage. Altered patterns of cellular processing and different cytokine expression, including TNF, IL-1, IL-2, IL-6, and IL17, have been defined in uveitis, and this has laid the pathway for targeted therapy...
April 2016: Best Practice & Research. Clinical Rheumatology
https://www.readbyqxmd.com/read/27873163/an-update-on-the-use-of-immunomodulators-in-primary-immunodeficiencies
#5
REVIEW
Pandiarajan Vignesh, Amit Rawat, Surjit Singh
The genomic revolution in the past decade fuelled by breathtaking advances in sequencing technologies has defined several new genetic diseases of the immune system. Many of these newly characterized diseases are a result of defects in genes involved in immune regulation. The discovery of these diseases has opened a vista of new therapeutic possibilities. Immunomodulatory agents, a hitherto unexplored therapeutic option in primary immunodeficiency diseases have been tried in a host of these newly described maladies...
November 21, 2016: Clinical Reviews in Allergy & Immunology
https://www.readbyqxmd.com/read/27870860/gene-expression-profile-of-high-ifn-%C3%AE-producers-stimulated-with-leishmania-braziliensis-identifies-genes-associated-with-cutaneous-leishmaniasis
#6
Marcia W Carneiro, Kiyoshi F Fukutani, Bruno B Andrade, Rebecca P Curvelo, Juqueline R Cristal, Augusto M Carvalho, Aldina Barral, Johan Van Weyenbergh, Manoel Barral-Netto, Camila I de Oliveira
BACKGROUND: The initial response to Leishmania parasites is essential in determining disease development or resistance. In vitro, a divergent response to Leishmania, characterized by high or low IFN-γ production has been described as a potential tool to predict both vaccine response and disease susceptibility in vivo. METHODS AND FINDINGS: We identified uninfected and healthy individuals that were shown to be either high- or low IFN-γ producers (HPs and LPs, respectively) following stimulation of peripheral blood cells with Leishmania braziliensis...
November 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27866265/proteomic-analysis-of-fasciola-hepatica-excretory-and-secretory-products-fhesps-involved-in-interacting-with-host-pbmcs-and-cytokines-by-shotgun-lc-ms-ms
#7
Qing Liu, Si-Yang Huang, Dong-Mei Yue, Jin-Lei Wang, Yujian Wang, Xiangrui Li, Xing-Quan Zhu
Fasciola hepatica is a helminth parasite with a worldwide distribution, which can cause chronic liver disease, fasciolosis, leading to economic losses in the livestock and public health in many countries. Control is mostly reliant on the use of drugs, and as a result, drug resistance has now emerged. The identification of F. hepatica genes involved in interaction between the parasite and host immune system is utmost important to elucidate the evasion mechanisms of the parasite and develop more effective strategies against fasciolosis...
November 19, 2016: Parasitology Research
https://www.readbyqxmd.com/read/27848994/the-host-genetic-background-defines-diverse-immune-reactivity-and-susceptibility-to-chronic-pseudomonas-aeruginosa-respiratory-infection
#8
Lorenza Spagnuolo, Maura De Simone, Nicola Ivan Lorè, Ida De Fino, Veronica Basso, Anna Mondino, Cristina Cigana, Alessandra Bragonzi
Patients with P. aeruginosa airways infection show markedly variable clinical phenotypes likely influenced by genetic backgrounds. Here, we investigated the cellular events involved in resistance and susceptibility to P. aeruginosa chronic infection using genetically distinct inbred mouse strains. As for patients, different murine genotypes revealed variable susceptibility to infection. When directly compared, resistant C3H/HeOuJ and susceptible A/J strains revealed distinct immune responsiveness to the pathogen...
November 16, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27817960/multifaceted-immune-responses-and-protective-efficacy-elicited-by-a-recombinant-autolyzed-salmonella-expressing-flic-flagellar-antigen-of-f18-escherichia-coli
#9
Gayeon Won, John Hwa Lee
Porcine edema disease (ED) caused by F18(+) Shiga toxin 2e-producing Escherichia coli (STEC) has imposed significant economic losses in the swine industry worldwide, resulting in sudden deaths in post-weaned piglets. The flagellin protein of F18(+) STEC, a structural component of the flagellar filament, is a known virulence factor that mediates adhesion and invasion to porcine epithelial cells. In this study, Salmonella inactivated by the E lysis gene and expressing the flagellin (fliC) antigen was genetically engineered utilizing a plasmid (pMMP184) carrying an efficient heterologous antigen delivery system...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27815118/discovery-of-phenoxyindazoles-and-phenylthioindazoles-as-ror%C3%AE-inverse-agonists
#10
Gilles Ouvry, Claire Bouix-Peter, Fabrice Ciesielski, Laurent Chantalat, Olivier Christin, Catherine Comino, Denis Duvert, Christophe Feret, Craig S Harris, Laurent Lamy, Anne-Pascale Luzy, Branislav Musicki, Danielle Orfila, Jonathan Pascau, Véronique Parnet, Agnès Perrin, Romain Pierre, Gaëlle Polge, Catherine Raffin, Yves Rival, Nathalie Taquet, Etienne Thoreau, Laurent F Hennequin
Targeting the IL17 pathway and more specifically the nuclear receptor RORγ is thought to be beneficial in multiple skin disorders. The Letter describes the discovery of phenoxyindazoles and thiophenoxy indazoles as potent RORγ inverse agonists. Optimization of the potency and efforts to mitigate the phototoxic liability of the series are presented. Finally, crystallization of the lead compound revealed that the series bound to an allosteric site of the nuclear receptor. Such compounds could be useful as tool compounds for understanding the impact of topical treatment on skin disease models...
October 12, 2016: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/27803782/inactivated-mycobacterium-phlei-inhalation-ameliorates-allergic-asthma-through-modulating-the-balance-of-cd4-cd25-regulatory-t-and-th17-cells-in-mice
#11
Moyu Ming, Zhixi Luo, Shengqiu Lv, Qixiang Sun, Chaoqian Li
OBJECTIVES: Th2 response is related to the aetiology of asthma, but the underlying mechanism is unclear. To address this point, the effect of nebulized inhalation of inactivated Mycobacterium phlei on modulation of asthmatic airway inflammation was investigated. MATERIALS AND METHODS: 24 male BALB/c mice were randomly divided into three groups: control group (Group A), asthma model group (Group B), and the medicated asthma model group (Group C). Group B and C were sensitized and challenged with ovalbumin (OVA)...
September 2016: Iranian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/27797827/anti-inflammatory-natural-product-goniothalamin-reduces-colitis-associated-and-sporadic-colorectal-tumorigenesis
#12
Débora Barbosa Vendramini-Costa, Ralph Francescone, David Posocco, Vivianty Hou, Oxana Dmitrieva, Harvey Hensley, João Ernesto de Carvalho, Ronaldo Aloise Pilli, Sergei Grivennikov
The tumor microenvironment offers multiple targets for cancer therapy, including pro-tumorigenic inflammation. Natural compounds represent an enormous source of new anti-inflammatory and anticancer agents. We previously showed that the styryl lactone goniothalamin (GTN) has promising antiproliferative and anti-inflammatory activities. Because inflammation is a major driver of colorectal cancer (CRC), we therefore evaluated the therapeutic and preventive potentials of GTN in colitis, colitis associated cancer (CAC) and spontaneous CRC...
October 24, 2016: Carcinogenesis
https://www.readbyqxmd.com/read/27797811/il4i1-augments-cns-remyelination-and-axonal-protection-by-modulating-t-cell-driven-inflammation
#13
Konstantina Psachoulia, Kelly A Chamberlain, Dongeun Heo, Stephanie E Davis, Jeremiah D Paskus, Sonia E Nanescu, Jeffrey L Dupree, Thomas A Wynn, Jeffrey K Huang
SEE PLUCHINO AND PERUZZOTTI-JAMETTI DOI101093/AWW266 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Myelin regeneration (remyelination) is a spontaneous process that occurs following central nervous system demyelination. However, for reasons that remain poorly understood, remyelination fails in the progressive phase of multiple sclerosis. Emerging evidence indicates that alternatively activated macrophages in central nervous system lesions are required for oligodendrocyte progenitor differentiation into remyelinating oligodendrocytes...
December 2016: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/27771185/role-of-antibodies-and-il17-mediated-immunity-in-protection-against-pneumococcal-otitis-media
#14
Marrit N Habets, Saskia van Selm, Fred J van Opzeeland, Elles Simonetti, Peter W M Hermans, Marien I de Jonge, Dimitri A Diavatopoulos
Widespread vaccination against Streptococcus pneumoniae (the pneumococcus) has significantly reduced pneumococcal disease caused by vaccine serotypes. Despite vaccination, overall pneumococcal colonization rates in children have not reduced and otitis media (OM) by non-vaccine serotypes remains one of the most common childhood infections. Pneumococcal surface protein A (PspA) has been shown to be a promising protein antigen to induce broad protection against pneumococcal colonization. However, its ability to protect against OM remains unclear...
October 19, 2016: Vaccine
https://www.readbyqxmd.com/read/27769811/aryl-hydrocarbon-receptor-ligands-in-cigarette-smoke-induce-production-of-interleukin-22-to-promote-pancreatic-fibrosis-in-models-of-chronic-pancreatitis
#15
Jing Xue, Qinglan Zhao, Vishal Sharma, Linh P Nguyen, Yvonne N Lee, Kim L Pham, Mouad Edderkaoui, Stephen J Pandol, Walter Park, Aida Habtezion
BACKGROUND & AIMS: Cigarette smoke has been identified as an independent risk factor for chronic pancreatitis (CP). Little is known about the mechanisms by which smoking promotes development of CP. We assessed the effects of aryl hydrocarbon receptor (AhR) ligands found in cigarette smoke on immune cell activation in humans and pancreatic fibrosis in animal models of CP. METHODS: We obtained serum samples from patients with CP treated at Stanford University hospital and healthy individuals (controls) and isolated CD4(+) T cells...
December 2016: Gastroenterology
https://www.readbyqxmd.com/read/27758873/systems-analysis-uncovers-inflammatory-th-tc17-driven-modules-during-acute-gvhd-in-monkey-and-man
#16
Scott N Furlan, Benjamin Watkins, Victor Tkachev, Sarah Cooley, Angela Panoskaltsis-Mortari, Kayla Betz, Melanie Brown, Daniel J Hunt, John B Schell, Katie Zeleski, Alison Yu, Cindy Giver, Edmund Waller, Jeffrey S Miller, Bruce R Blazar, Leslie S Kean
One of the central challenges of transplantation is the development of alloreactivity despite the use of multi-agent immunoprophylaxis. Effective control of this immune-suppression-resistant T cell activation represents one of the key unmet needs in the fields of both solid organ and hematopoietic stem cell transplant (HCT). To address this unmet need, we have used a highly-translational non-human primate model to interrogate the transcriptional signature of T cells during Breakthrough Acute GVHD that occurs in the setting of clinically-relevant immune suppression and compared this to the Hyperacute GVHD, that develops in unprophylaxed or sub-optimally prophylaxed transplant recipients...
October 6, 2016: Blood
https://www.readbyqxmd.com/read/27752361/immune-modulating-effects-of-bevacizumab-in-metastatic-non-small-cell-lung-cancer-patients
#17
E C Martino, G Misso, P Pastina, S Costantini, F Vanni, C Gandolfo, C Botta, F Capone, A Lombardi, L Pirtoli, P Tassone, C Ulivieri, P Tagliaferri, M G Cusi, M Caraglia, P Correale
The mPEBev is an anticancer regimen which combines a chemotherapy doublet, based on cisplatin and oral etoposide (mPE), with bevacizumab (mPEBev), a mAb targeting the vasculo-endothelial growth factor (VEGF). In previous studies, this regimen showed powerful anti-angiogenetic effects and significant antitumor activity in metastatic non-small-cell lung cancer (mNSCLC) patients. We also recorded the best benefit in patients exhibiting low-systemic inflammatory profile at baseline. On these bases, we hypothesized that mPEBev antitumor activity could be partially related to bevacizumab-associated immunological effects...
2016: Cell Death Discovery
https://www.readbyqxmd.com/read/27725632/tiam1-rac1-complex-controls-il17a-transcription-and-autoimmunity
#18
Ahmed T Kurdi, Ribal Bassil, Marta Olah, Chuan Wu, Sheng Xiao, Mariko Taga, Michael Frangieh, Thomas Buttrick, William Orent, Elizabeth M Bradshaw, Samia J Khoury, Wassim Elyaman
RORγt is a master transcription factor of Th17 cells and considered as a promising drug target for the treatment of autoimmune diseases. Here, we show the guanine nucleotide exchange factor, Tiam1, and its cognate Rho-family G protein, Rac1, regulate interleukin (IL)17A transcription and autoimmunity. Whereas Tiam1 genetic deficiency weakens IL-17A expression partially and inhibits the development of experimental autoimmune encephalomyelitis (EAE), deletion of Rac1 in T cells exhibits more robust effects on Th17 cells and EAE...
October 11, 2016: Nature Communications
https://www.readbyqxmd.com/read/27718760/brodalumab-for-the-treatment-of-psoriasis
#19
M Galluzzo, S D'Adamio, L Bianchi, M Talamonti
Psoriasis is a complex disease in which the alteration of the IL-23/Th17 axis appears to be crucial for its pathogenic mechanisms, and anti-IL17 agents are rapidly becoming important therapeutic tools. Brodalumab, a fully human Chinese hamster ovary cell-derived immunoglobulin G2 (IgG2) anti-IL-17RA monoclonal antibody, is currently the most-developed treatment that binds to the IL-17RA. The authors review and provide updates of efficacy and safety by several studies on brodalumab. Areas covered: A PubMed search was performed for relevant literature...
October 10, 2016: Expert Review of Clinical Immunology
https://www.readbyqxmd.com/read/27693422/endogenously-produced-nonclassical-vitamin-d-hydroxy-metabolites-act-as-biased-agonists-on-vdr-and-inverse-agonists-on-ror%C3%AE-and-ror%C3%AE
#20
Andrzej T Slominski, Tae-Kang Kim, Judith V Hobrath, Allen S W Oak, Edith K Y Tang, Elaine W Tieu, Wei Li, Robert C Tuckey, Anton M Jetten
The classical pathway of vitamin D activation follows the sequence D3→25(OH)D3→1,25(OH)2D3 with the final product acting on the receptor for vitamin D (VDR). An alternative pathway can be started by the action of CYP11A1 on the side chain of D3, primarily producing 20(OH)D3, 22(OH)D3, 20,23(OH)2D3, 20,22(OH)2D3 and 17,20,23(OH)3D3. Some of these metabolites are hydroxylated by CYP27B1 at C1α, by CYP24A1 at C24 and C25, and by CYP27A1 at C25 and C26. The products of these pathways are biologically active...
September 28, 2016: Journal of Steroid Biochemistry and Molecular Biology
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