Luis C Morales, Amarnath Rajendran, Aysha Ansari, Remant Kc, Mohammad Nasrullah, Kitipong Kiti, Panadda Yotsomnuk, Marianna Kulka, Daniel Nisakar Meenakshi Sundaram, Hasan Uludağ
Small interfering RNAs (siRNAs) have emerged as a powerful tool to manipulate gene expression in vitro . However, their potential therapeutic application encounters significant challenges, such as degradation in vivo, limited cellular uptake, and restricted biodistribution, among others. This study evaluates the siRNA delivery efficiency of three different lipid-substituted polyethylenimine (PEI)-based carriers, named Leu-Fect A-C, to different organs in vivo , including xenograft tumors, when injected into the bloodstream of mice...
January 30, 2024: Molecular Pharmaceutics