Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#21
JOURNAL ARTICLE
Emanuela-Alice Luță, Andrei Biță, Alina Moroșan, Dan Eduard Mihaiescu, Dragoș Paul Mihai, Liliana Popescu, Ludovic Everard Bejenaru, Cornelia Bejenaru, Violeta Popovici, Octavian Tudorel Olaru, Cerasela Elena Gîrd
Oxidative stress is the most critical factor in multiple functional disorders' development, and natural antioxidants could protect the human body against it. Our study aims to investigate the polyphenol content of four extracts of two medicinal plants ( Rosmarinus officinalis L. and Thymus vulgaris L.) and analyze the correlation with their antioxidant activity. The research was carried out on extracts of rosemary and thyme obtained from species cultivated together in plant communities. Both were compared with extracts from species cultivated in individual crops (control crops)...
July 19, 2023: International Journal of Molecular Sciences
#22
REVIEW
Masaya Iwamuro, Takehiro Tanaka, Motoyuki Otsuka
Recent studies have advanced our understanding of the pathophysiology of autoimmune gastritis, particularly its molecular aspects. The most noteworthy recent advancement lies in the identification of several candidate genes implicated in the pathogenesis of pernicious anemia through genome-wide association studies. These genes include PTPN22 , PNPT1 , HLA-DQB1 , and IL2RA . Recent studies have also directed attention towards other genes such as ATP4A , ATP4B , AIRE , SLC26A7 , SLC26A9 , and BACH2 polymorphism...
June 21, 2023: Current Issues in Molecular Biology
#23
Akshay Akshay, Mitali Katoch, Navid Shekarchizadeh, Masoud Abedi, Ankush Sharma, Fiona C Burkhard, Rosalyn M Adam, Katia Monastyrskaya, Ali Hashemi Gheinani
BACKGROUND: Machine learning (ML) has emerged as a vital asset for researchers to analyze and extract valuable information from complex datasets. However, developing an effective and robust ML pipeline can present a real challenge, demanding considerable time and effort, thereby impeding research progress. Existing tools in this landscape require a profound understanding of ML principles and programming skills. Furthermore, users are required to engage in the comprehensive configuration of their ML pipeline to obtain optimal performance...
July 4, 2023: bioRxiv
#24
JOURNAL ARTICLE
A-Reum Nam, Min Heo, Kang-Hoon Lee, Ji-Yoon Kim, Sung-Ho Won, Je-Yoel Cho
BACKGROUND: Genome-wide dysregulation of CpG methylation accompanies tumor progression and characteristic states of cancer cells, prompting a rationale for biomarker development. Understanding how the archetypic epigenetic modification determines systemic contributions of immune cell types is the key to further clinical benefits. RESULTS: In this study, we characterized the differential DNA methylome landscapes of peripheral blood mononuclear cells (PBMCs) from 76 canines using methylated CpG-binding domain sequencing (MBD-seq)...
July 18, 2023: BMC Genomics
#25
JOURNAL ARTICLE
Adriane Silva Oliveira, Lara Mata Aredes-Riguetti, Bernardo Acácio Santini Pereira, Carlos Roberto Alves, Franklin Souza-Silva
Degrons are short peptide sequences that signalize target sites for protein degradation by proteases. Herein, we bring forth the discussion on degrons present in proteins related to the immune system of Mus musculus that are potential targets for cysteine and serine proteases of Leishmania spp. and their possible roles on host immune regulation by parasites. The Merops database was used to identify protease substrates and proteases sequence motifs, while MAST/MEME Suite was applied to find degron motifs in murine cytokines (IFN-y, IL-4, IL-5, IL-13, IL-17) and transcription factors (NF-kappaB, STAT-1, AP-1, CREB, and BACH2)...
May 23, 2023: Vaccines
#26
JOURNAL ARTICLE
Fabian M P Kaiser, Iga Janowska, Roberta Menafra, Melanie de Gier, Jakov Korzhenevich, Ingrid Pico-Knijnenburg, Indu Khatri, Ansgar Schulz, Taco W Kuijpers, Arjan C Lankester, Lukas Konstantinidis, Miriam Erlacher, Susan Kloet, Pauline A van Schouwenburg, Marta Rizzi, Mirjam van der Burg
Although absence of interleukin-7 (IL-7) signaling completely abrogates T and B lymphopoiesis in mice, patients with severe combined immunodeficiency caused by mutations in the IL-7 receptor α chain (IL-7Rα) still generate peripheral blood B cells. Consequently, human B lymphopoiesis has been thought to be independent of IL-7 signaling. Using flow cytometric analysis and single-cell RNA sequencing of bone marrow samples from healthy controls and patients who are IL-7Rα deficient, in combination with in vitro modeling of human B-cell differentiation, we demonstrate that IL-7R signaling plays a crucial role in human B lymphopoiesis...
September 28, 2023: Blood
#27
JOURNAL ARTICLE
Juyi Li, Chunjia Kou, Tiantian Sun, Jia Liu, Haiqing Zhang
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common progressive liver disease worldwide. It can cause liver cancer and possibly death. Abnormal immune infiltration is involved in the progression of NAFLD. The aim of this study was to identify and validate the hub immune-related genes in NAFLD. METHODS: Microarray data were downloaded from Gene Expression Omnibus, and immune-related differentially expressed genes (IRDEGs) were obtained. A protein-protein interaction network was used to further screen...
2023: International Journal of General Medicine
#28
REVIEW
Jorge L Trujillo-Ochoa, Majid Kazemian, Behdad Afzali
Forkhead box protein 3-expressing (FOXP3+ ) regulatory T cells (Treg cells) suppress conventional T cells and are essential for immunological tolerance. FOXP3, the master transcription factor of Treg cells, controls the expression of multiples genes to guide Treg cell differentiation and function. However, only a small fraction (<10%) of Treg cell-associated genes are directly bound by FOXP3, and FOXP3 alone is insufficient to fully specify the Treg cell programme, indicating a role for other accessory transcription factors operating upstream, downstream and/or concurrently with FOXP3 to direct Treg cell specification and specialized functions...
June 19, 2023: Nature Reviews. Immunology
#29
JOURNAL ARTICLE
Paola Benaglio, Jacklyn Newsome, Jee Yun Han, Joshua Chiou, Anthony Aylward, Sierra Corban, Michael Miller, Mei-Lin Okino, Jaspreet Kaur, Sebastian Preissl, David U Gorkin, Kyle J Gaulton
Gene regulation is highly cell type-specific and understanding the function of non-coding genetic variants associated with complex traits requires molecular phenotyping at cell type resolution. In this study we performed single nucleus ATAC-seq (snATAC-seq) and genotyping in peripheral blood mononuclear cells from 13 individuals. Clustering chromatin accessibility profiles of 96,002 total nuclei identified 17 immune cell types and sub-types. We mapped chromatin accessibility QTLs (caQTLs) in each immune cell type and sub-type using individuals of European ancestry which identified 6,901 caQTLs at FDR < ...
June 8, 2023: PLoS Genetics
#30
REVIEW
Shigeru Iwata, Maiko Hajime Sumikawa, Yoshiya Tanaka
Systemic lupus erythematosus (SLE) is an inflammatory autoimmune disease involving multiple organs in which B cells perform important functions such as antibody and cytokine production and antigen presentation. B cells are activated and differentiated by the primary B cell receptor, co-stimulatory molecule signals-such as CD40/CD40L-, the Toll-like receptors 7,9, and various cytokine signals. The importance of immunometabolism in the activation, differentiation, and exerting functions of B cells and other immune cells has been widely reported in recent years...
2023: Frontiers in Immunology
#31
REVIEW
Qianben Song, Xin Mao, Mengjia Jing, Yu Fu, Wei Yan
BTB and CNC homologous (BACH) proteins, including BACH1 and BACH2, are transcription factors that are widely expressed in human tissues. BACH proteins form heterodimers with small musculoaponeurotic fibrosarcoma (MAF) proteins to suppress the transcription of target genes. Furthermore, BACH1 promotes the transcription of target genes. BACH proteins regulate physiological processes, such as the differentiation of B cells and T cells, mitochondrial function, and heme homeostasis as well as pathogenesis related to inflammation, oxidative-stress damage caused by drugs, toxicants, or infections; autoimmunity disorders; and cancer angiogenesis, epithelial-mesenchymal transition, chemotherapy resistance, progression, and metabolism...
2023: Frontiers in Physiology
#32
JOURNAL ARTICLE
Xueying Liu, Yahu Miao, Chao Liu, Wan Lu, Qing Feng, Qiu Zhang
BACKGROUND: Autoimmune thyroid disease (AITD) is induced by various factors, including inheritability, which regulates gene expression. Multiple loci correlated with AITD have been discovered utilizing genome-wide association studies (GWASs). Nevertheless, demonstrating the biological relevance and function of these genetic loci is difficult. METHODS: The FUSION software was utilized to define genes that were expressed differentially in AITD using a transcriptome-wide association study (TWAS) method in accordance with GWAS summary statistics from the largest genome-wide association study of 755,406 AITD individuals (30,234 cases and 725,172 controls) and levels of gene expression from two tissue datasets (blood and thyroid)...
2023: Frontiers in Immunology
#33
JOURNAL ARTICLE
Patricia da Silva-Buttkus, Nadine Spielmann, Tanja Klein-Rodewald, Christine Schütt, Antonio Aguilar-Pimentel, Oana V Amarie, Lore Becker, Julia Calzada-Wack, Lillian Garrett, Raffaele Gerlini, Markus Kraiger, Stefanie Leuchtenberger, Manuela A Östereicher, Birgit Rathkolb, Adrián Sanz-Moreno, Claudia Stöger, Sabine M Hölter, Claudia Seisenberger, Susan Marschall, Helmut Fuchs, Valerie Gailus-Durner, Martin Hrabě de Angelis
Rare diseases (RDs) are a challenge for medicine due to their heterogeneous clinical manifestations and low prevalence. There is a lack of specific treatments and only a few hundred of the approximately 7,000 RDs have an approved regime. Rapid technological development in genome sequencing enables the mass identification of potential candidates that in their mutated form could trigger diseases but are often not confirmed to be causal. Knockout (KO) mouse models are essential to understand the causality of genes by allowing highly standardized research into the pathogenesis of diseases...
May 9, 2023: Mammalian Genome: Official Journal of the International Mammalian Genome Society
#34
JOURNAL ARTICLE
Lina Zhou, Gan Sun, Ran Chen, Junjie Chen, Shuyu Fang, Qiling Xu, Wenjing Tang, Rongxin Dai, Zhiyong Zhang, Yunfei An, Xuemei Tang, Xiaodong Zhao
BACH2-related immunodeficiency and autoimmunity (BRIDA) is an inborn error of immunity, newly reported in 2017, presenting with symptoms of immunoglobulin deficiency and ongoing colitis. Studies using a mouse model have demonstrated that BACH2 deficiency predisposes individuals to systemic lupus erythematosus (SLE); however, no BACH2 deficiency has been reported in SLE patients. Here we describe a patient with BRIDA presenting with early-onset SLE, juvenile dermatomyositis, and IgA deficiency. Whole exome sequencing analysis of the patient and her parents revealed a novel heterozygous point mutation in BACH2, c...
August 2023: Journal of Clinical Immunology
#35
JOURNAL ARTICLE
Kazuma Iida, Kensuke Suga, Kotaro Suzuki, Shunjiro Kurihara, Yoko Yabe, Takahiro Kageyama, Kazuyuki Meguro, Shigeru Tanaka, Arifumi Iwata, Akira Suto, Hiroshi Nakajima
T follicular regulatory (Tfr) cells, a subset of CD4+ Foxp3+ regulatory T (Treg) cells, locate to the lymphoid follicle and germinal center (GC) and regulate antibody responses. Tfr cells express the functional molecules of follicular helper T (Tfh) cells, including CXCR5 and Bcl6. CD25- mature Tfr cells differentiate from CD25+ Treg cells through CD25+ immature Tfr cells. Others and we have shown that Achaete-scute complex homolog 2 (Ascl2) plays a role in Tfh cell development; however, the role of Ascl2 in the development of Tfr cells remains unclear...
April 22, 2023: Biochemical and Biophysical Research Communications
#36
JOURNAL ARTICLE
Han She, Lei Tan, Ruibo Yang, Jie Zheng, Yi Wang, Yuanlin Du, Xiaoyong Peng, Qinghui Li, Haibin Lu, Xinming Xiang, Yi Hu, Liangming Liu, Tao Li
Background: The precise diagnostic and prognostic biological markers were needed in immunotherapy for sepsis. Considering the role of necroptosis and immune cell infiltration in sepsis, differentially expressed necroptosis-related genes (DE-NRGs) were identified, and the relationship between DE-NRGs and the immune microenvironment in sepsis was analyzed. Methods: Machine learning algorithms were applied for screening hub genes related to necroptosis in the training cohort. CIBERSORT algorithms were employed for immune infiltration landscape analysis...
2023: Frontiers in Genetics
#37
JOURNAL ARTICLE
Akimichi Inaba, Zewen Kelvin Tuong, Tian X Zhao, Andrew P Stewart, Rebeccah Mathews, Lucy Truman, Rouchelle Sriranjan, Jane Kennet, Kourosh Saeb-Parsy, Linda Wicker, Frank Waldron-Lynch, Joseph Cheriyan, John A Todd, Ziad Mallat, Menna R Clatworthy
Dysfunction of interleukin-10 producing regulatory B cells has been associated with the pathogenesis of autoimmune diseases, but whether regulatory B cells can be therapeutically induced in humans is currently unknown. Here we demonstrate that a subset of activated B cells expresses CD25, and the addition of low-dose recombinant IL-2 to in vitro stimulated peripheral blood and splenic human B cells augments IL-10 secretion. Administration of low dose IL-2, aldesleukin, to patients increases IL-10-producing B cells...
April 12, 2023: Nature Communications
#38
JOURNAL ARTICLE
Bruna Cardoso Jacintho, Bruna de Moraes Mazetto Fonseca, Bidossessi Wilfried Hounkpe, Jose Diogo Oliveira, Ana Paula Rosa Dos Santos, Camila de Oliveira Vaz, Erich Vinicius de Paula, Fernanda Andrade Orsi
Thrombotic primary antiphospholipid syndrome (t-PAPS) is an acquired condition characterized by heterogeneous thrombotic manifestations, which is intriguing since venous and arterial thrombosis appear to have distinct pathogenesis. Gene expression analysis may constitute a new approach to evaluate potential similarities or differences between the clinical manifestations of t-PAPS. Recently, dysregulation of the ANXA3, TNFAIP6, TXK, BACH2 , and SERPINB2 genes has been associated with both arterial and venous thrombosis in the general population...
2023: Frontiers in Medicine
#39
JOURNAL ARTICLE
Marta Fichna, Piotr P Malecki, Magdalena Żurawek, Katarzyna Furman, Boleslaw Gebarski, Piotr Fichna, Marek Ruchala
Since individuals with Addison's disease (AD) present considerable co-occurrence of additional autoimmune conditions, clustering of autoimmunity was also predicted among their relatives. The study was aimed to evaluate circulating autoantibodies in first-degree relatives of patients with AD and to correlate them with the established genetic risk factors (PTPN22 rs2476601, CTLA4 rs231775, and BACH2 rs3757247). Antibodies were evaluated using validated commercial assays and genotyping was performed with TaqMan chemistry...
April 1, 2023: Endocrine Connections
#40
Liam D Cato, Rick Li, Henry Y Lu, Fulong Yu, Mariel Wissman, Baraka S Mkumbe, Supachai Ekwattanakit, Patrick Deelen, Liberata Mwita, Raphael Zozimus Sangeda, Thidarat Suksangpleng, Suchada Riolueang, Paola G Bronson, Dirk S Paul, Emily Kawabata, William J Astle, Francois Aguet, Kristin Ardlie, Aitzkoa Lopez de Lapuente Portilla, Guolian Kang, Yingze Zhang, Seyed Mehdi Nouraie, Victor R Gordeuk, Mark T Gladwin, Melanie E Garrett, Allison Ashley-Koch, Marilyn J Telen, Brian Custer, Shannon Kelly, Carla Dinardo, Ester Cerdeira Sabino, Paula Loureiro, Anna Barbara Carneiro-Proietti, Claudia Maximo, Adriana Mendez, Angelika Hammerer-Lercher, Vivien A Sheehan, Mitchell J Weiss, Lude Franke, Bjorn Nilsson, Adam S Butterworth, Vip Viprakasit, Siana Nkya, Vijay G Sankaran
Human genetic variation has enabled the identification of several key regulators of fetal-to-adult hemoglobin switching, including BCL11A, resulting in therapeutic advances. However, despite the progress made, limited further insights have been obtained to provide a fuller accounting of how genetic variation contributes to the global mechanisms of fetal hemoglobin (HbF) gene regulation. Here, we have conducted a multi-ancestry genome-wide association study of 28,279 individuals from several cohorts spanning 5 continents to define the architecture of human genetic variation impacting HbF...
March 28, 2023: medRxiv
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
