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https://www.readbyqxmd.com/read/28325019/frameless-stereotactic-radiosurgery-fsrs-end-to-end-test-with-ebt-xd-gafchromic-film
#1
Yulin Song, Ceferino Obcemea, Boris Mueller, Borys Mychalczak
Frame-based stereotactic radiosurgery (SRS) has been widely used to treat functional disorders, vascular lesions, and primary benign and malignant tumors. Recently, SRS is being increasingly used to treat solitary brain metastases. However, due to its highly invasive nature, frame-based SRS is being gradually replaced by frameless SRS (fSRS). fSRS aims at improving patient comfort and achieving stable patient immobilization with non-invasive means and accurate target localization with image guidance technique...
August 2016: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/28315230/clinical-outcome-and-molecular-characterization-of-brain-metastases-from-esophageal-and-gastric-cancer-a-systematic-review
#2
REVIEW
Michele Ghidini, Fausto Petrelli, Jens Claus Hahne, Annamaria De Giorgi, Laura Toppo, Claudio Pizzo, Margherita Ratti, Sandro Barni, Rodolfo Passalacqua, Gianluca Tomasello
The aim of the study was to collect the available data on central nervous system (CNS) metastases from esophageal and gastric cancer. A PubMed, EMBASE, SCOPUS, Web of Science, LILACS, Ovid and Cochrane Library search was performed. Thirty-seven studies including 779 patients were considered. Among the data extracted, treatment of tumor and brain metastases (BMs), time to BMs development, number and subsite, extracerebral metastases rate, median overall survival (OS) and prognostic factors were included. For esophageal cancer, the median OS from diagnosis of BMs was 4...
April 2017: Medical Oncology
https://www.readbyqxmd.com/read/28306548/repeated-diffusion-mri-reveals-earliest-time-point-for-stratification-of-radiotherapy-response-in-brain-metastases
#3
Faisal Mahmood, Helle H Johannesen, Poul Geertsen, Rasmus H Hansen
An imaging biomarker for early prediction of treatment response potentially provides a non-invasive tool for better prognostics and individualized management of the disease. Radiotherapy (RT) response is generally related to changes in gross tumor volume manifesting months later. In this prospective study we investigated the apparent diffusion coefficient (ADC), perfusion fraction and pseudo diffusion coefficient derived from diffusion weighted MRI as potential early biomarkers for radiotherapy response of brain metastases...
March 17, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28303695/dynamic-contrast-enhanced-mri-perfusion-for-differentiating-between-melanoma-and-lung-cancer-brain-metastases
#4
Vaios Hatzoglou, Jamie Tisnado, Alpesh Mehta, Kyung K Peck, Mariza Daras, Antonio M Omuro, Kathryn Beal, Andrei I Holodny
Brain metastases originating from different primary sites overlap in appearance and are difficult to differentiate with conventional MRI. Dynamic contrast-enhanced (DCE)-MRI can assess tumor microvasculature and has demonstrated utility in characterizing primary brain tumors. Our aim was to evaluate the performance of plasma volume (Vp) and volume transfer coefficient (K(trans) ) derived from DCE-MRI in distinguishing between melanoma and nonsmall cell lung cancer (NSCLC) brain metastases. Forty-seven NSCLC and 23 melanoma brain metastases were retrospectively assessed with DCE-MRI...
March 17, 2017: Cancer Medicine
https://www.readbyqxmd.com/read/28301662/brain-metastases-in-newly-diagnosed-breast-cancer-a-population-based-study
#5
Allison M Martin, Daniel N Cagney, Paul J Catalano, Laura E Warren, Jennifer R Bellon, Rinaa S Punglia, Elizabeth B Claus, Eudocia Q Lee, Patrick Y Wen, Daphne A Haas-Kogan, Brian M Alexander, Nancy U Lin, Ayal A Aizer
Importance: Population-based estimates of the incidence and prognosis of brain metastases at diagnosis of breast cancer are lacking. Objective: To characterize the incidence proportions and median survivals of patients with breast cancer and brain metastases at the time of cancer diagnosis. Design, Setting, and Participants: Patients with breast cancer and brain metastases at the time of diagnosis were identified using the Surveillance, Epidemiology, and End Results (SEER) database of the National Cancer Institute...
March 16, 2017: JAMA Oncology
https://www.readbyqxmd.com/read/28300909/multiple-cutaneous-melanomas-associated-with-gastric-and-brain-metastases
#6
Lara Caroline Grander, Fernanda Cabral, Alice Paixão Lisboa, Gabrielle Vale, Carlos Baptista Barcaui, Juan Manuel Pineiro Maceira
The occurrence of multiple primary melanomas in a single individual is rare. Most commonly, malignant melanocytic lesions subsequent to the initial diagnosis of melanoma are secondary cutaneous metastases. We report a patient with gastrointestinal bleeding from gastric metastasis of cutaneous melanoma. During clinical evaluation and staging, we discovered a brain metastasis associated with 3 synchronous primary cutaneous melanomas. We suggest the research on the mutation in the cyclin-dependent kinase inhibitor 2A (CDKN2A) (INK4a) in such cases...
September 2016: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/28299642/cerebromicrovascular-dysfunction-predicts-cognitive-decline-and-gait-abnormalities-in-a-mouse-model-of-whole-brain-irradiation-induced-accelerated-brain-senescence
#7
Zoltan Ungvari, Stefano Tarantini, Peter Hertelendy, M Noa Valcarcel-Ares, Gabor A Fülöp, Sreemathi Logan, Tamas Kiss, Eszter Farkas, Anna Csiszar, Andriy Yabluchanskiy
Whole brain irradiation (WBI) is a mainstream therapy for patients with both identifiable brain metastases and prophylaxis for microscopic malignancies. However, it also promotes accelerated senescence in healthy tissues and leads to progressive cognitive dysfunction in up to 50% of tumor patients surviving long term after treatment, due to γ-irradiation-induced cerebromicrovascular injury. Moment-to-moment adjustment of cerebral blood flow (CBF) via neuronal activity-dependent cerebromicrovascular dilation (functional hyperemia) has a critical role in maintenance of healthy cognitive function...
February 2017: Geroscience
https://www.readbyqxmd.com/read/28298015/toward-the-complete-control-of-brain-metastases-using-surveillance-screening-and-stereotactic-radiosurgery
#8
Amparo Wolf, Svetlana Kvint, Abraham Chachoua, Anna Pavlick, Melissa Wilson, Bernadine Donahue, John G Golfinos, Joshua Silverman, Douglas Kondziolka
OBJECTIVE The incidence of brain metastases is increasing with improved systemic therapies, many of which have a limited impact on intracranial disease. Stereotactic radiosurgery (SRS) is a first-line management option for brain metastases. The purpose of this study was to determine if there is a threshold tumor size below which local control (LC) rates approach 100%, and to relate these findings to the use of routine surveillance brain imaging. METHODS From a prospective registry, 200 patients with 1237 brain metastases were identified who underwent SRS between December 2012 and May 2015...
February 17, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28297450/dosimetric-comparison-between-cone-iris-based-and-incise-mlc-based-cyberknife-plans-for-single-and-multiple-brain-metastases
#9
Si Young Jang, Ron Lalonde, Cihat Ozhasoglu, Steven Burton, Dwight Heron, M Saiful Huq
We performed an evaluation of the CyberKnife InCise MLC by comparing plan qualities for single and multiple brain lesions generated using the first version of InCise MLC, fixed cone, and Iris collimators. We also investigated differences in delivery efficiency among the three collimators. Twenty-four patients with single or multiple brain mets treated previously in our clinic on a CyberKnife M6 using cone/Iris collimators were selected for this study. Treatment plans were generated for all lesions using the InCise MLC...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28297431/dosimetric-validation-for-an-automatic-brain-metastases-planning-software-using-single-isocenter-dynamic-conformal-arcs
#10
Haisong Liu, Jun Li, Evangelos Pappas, David Andrews, James Evans, Maria Werner-Wasik, Yan Yu, Adam Dicker, Wenyin Shi
An automatic brain-metastases planning (ABMP) software has been installed in our institution. It is dedicated for treating multiple brain metastases with radiosurgery on linear accelerators (linacs) using a single-setup isocenter with noncoplanar dynamic conformal arcs. This study is to validate the calculated absolute dose and dose distribution of ABMP. Three types of measurements were performed to validate the planning software: 1, dual micro ion chambers were used with an acrylic phantom to measure the absolute dose; 2, a 3D cylindrical phantom with dual diode array was used to evaluate 2D dose distribution and point dose for smaller targets; and 3, a 3D pseudo-in vivo patient-specific phantom filled with polymer gels was used to evaluate the accuracy of 3D dose distribution and radiation delivery...
September 2016: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28296581/three-year-follow-up-of-an-alectinib-phase-i-ii-study-in-alk-positive-non-small-cell-lung-cancer-af-001jp
#11
Tomohide Tamura, Katsuyuki Kiura, Takashi Seto, Kazuhiko Nakagawa, Makoto Maemondo, Akira Inoue, Toyoaki Hida, Hiroshige Yoshioka, Masao Harada, Yuichiro Ohe, Naoyuki Nogami, Haruyasu Murakami, Hiroshi Kuriki, Tadashi Shimada, Tomohiro Tanaka, Kengo Takeuchi, Makoto Nishio
Purpose Alectinib is an anaplastic lymphoma kinase (ALK) -specific kinase inhibitor that seems to be effective against non-small-cell lung cancer (NSCLC) with a variety of ALK mutations. The primary analysis of AF-001JP reported a promising overall response rate. To assess progression-free survival (PFS) and overall survival (OS), patients from the phase II part of AF-001JP were followed up for approximately 3 years. Patients and Methods Oral alectinib 300 mg was administered twice per day to patients with ALK inhibitor-naïve, ALK-positive NSCLC who had progressed after one or more regimens of previous chemotherapy...
March 15, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28293961/commentary-preconceptions-about-the-neurosurgical-management-of-brain-metastases
#12
Rasheed Zakaria, Michael D Jenkinson
No abstract text is available yet for this article.
March 15, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28292994/-a-recurrent-case-of-thymic-adenocarcinoma-effectively-treated-with-s-1-over-a-long-term-period
#13
Munehisa Takata, Isao Matsumoto, Yusuke Tanaka, Daisuke Saito, Shuhei Yoshida, Seiichi Kakegawa, Masaya Tamura, Hirofumi Takemura, Hiroko Ikeda
A 61-year-old woman with an abnormal radiograph shadow in her anterior mediastinum was admitted to our hospital and underwent an extended thymectomy. The pathological diagnosis of the tumor was a non-papillary adenocarcinoma of the thymus in pathological stage IV b using the Masaoka classification owing to mediastinal lymph node metastasis. We found parasternal lymph node metastases 5 months after her first operation, and subsequently, she underwent surgery and adjuvant radiotherapy. We found systemic lymph node metastases and metastatic lesions in distant organs, including her lungs, brain, and kidney 27 months after her first operation...
March 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28291941/influence-of-the-jaw-tracking-technique-on-the-dose-calculation-accuracy-of-small-field-vmat-plans
#14
REVIEW
Ans C C Swinnen, Michel C Öllers, Erik Roijen, Sebastiaan M Nijsten, Frank Verhaegen
PURPOSE: The aim of this study was to evaluate experimentally the accuracy of the dose calculation algorithm AcurosXB in small field highly modulated Volumetric Modulated Arc Therapy (VMAT). METHOD: The 1000SRS detector array inserted in the rotational Octavius 4D phantom (PTW) was used for 3D dose verification of VMAT treatments characterized by small to very small targets. Clinical treatment plans (n = 28) were recalculated on the phantom CT data set in the Eclipse TPS...
January 2017: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/28290769/sequencing-brain-metastases-and-opportunities-for-targeted-therapies
#15
Ugonma N Chukwueke, Priscilla K Brastianos
CNS metastases have long been recognized as a common and late complication of systemic malignancies. They represent the most common tumor of the brain. As outcomes and overall survival improve with better tolerated and more durable responses from therapies for systemic cancers, the incidence and prevalence of brain metastases is likely to increase. Among the most common systemic cancers leading to brain metastases include lung, melanoma, breast (triple-negative histology) and renal cell cancers. To date, there has been infrequent involvement of gastrointestinal and gynecologic malignancies; however, this may also change, reflecting improvement in overall survival and therapeutic regimens...
March 14, 2017: Pharmacogenomics
https://www.readbyqxmd.com/read/28290227/outcome-after-craniotomy-for-recurrent-cranial-metastases
#16
Oliver Kennion, Damian Holliman
OBJECTIVE: To investigate the outcomes of patients with recurrent/progressive cranial metastases who underwent re-do craniotomy and to assess the utility of surgery as a treatment option. METHODS: A retrospective study was conducted assessing survival after re-do craniotomy for recurrent or progressive cranial metastases. 29 patients were identified between January 2006 and December 2013. Data was gathered from a prospective pathology database, patients' notes and electronic records...
March 14, 2017: British Journal of Neurosurgery
https://www.readbyqxmd.com/read/28288939/breast-cancer-resistance-protein-bcrp-abcg2-and-p-glycoprotein-p-gp-abcb1-transport-afatinib-and-restrict-its-oral-availability-and-brain-accumulation
#17
Stéphanie van Hoppe, Rolf W Sparidans, Els Wagenaar, Jos H Beijnen, Alfred H Schinkel
Afatinib is a highly selective, irreversible inhibitor of EGFR and (HER)-2. It is orally administered for the treatment of patients with EGFR mutation-positive types of metastatic NSCLC. We investigated whether afatinib is a substrate for the multidrug efflux transporters ABCB1 and ABCG2 and whether these transporters influence oral availability and brain and other tissue accumulation of afatinib. We used in vitro transport assays to assess human (h)ABCB1-, hABCG2- or murine (m)Abcg2-mediated transport of afatinib...
March 10, 2017: Pharmacological Research: the Official Journal of the Italian Pharmacological Society
https://www.readbyqxmd.com/read/28288046/fdg-pet-ct-in-pediatric-neurolymphomatosis
#18
Carole de Vaugelade, Henri de Clermont-Gallerande, Marie Meyer, Aude My Duyen Tiphaine, Alice Benjamin, Stephane Ducassou, Jean-François Chateil, Philippe Fernandez
An 8-year-old girl presented with back and leg pain and left arm and leg paresis. Lumbar puncture was suggestive of lymphocytic meningitis without identified organism. A second lumbar puncture demonstrated a large number of lymphoid B cells, with positive immunohistochemical staining for CD20 and CD25, proving the diagnosis of neurolymphomatosis. Brain and spine MRI demonstrated involvement of cervical and lumbosacral nerve roots. FDG PET/CT showed multiple bone metastases in addition to nerve involvement. Postchemotherapy FDG PET/CT demonstrated complete metabolic response...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28286925/cabozantinib-for-renal-cell-carcinoma-current-and-future-paradigms
#19
REVIEW
Ahmed Abdelaziz, Ulka Vaishampayan
Cabozantinib was approved by the FDA in April 2016 for the treatment of advanced renal cancer, pretreated with at least one prior antiangiogenic therapy. This is the first agent in the therapy of kidney cancer to show a statistically significant improvement in all three endpoints of clinical efficacy, response rate, progression free survival, and overall survival (OS), in a phase III randomized trial. The reporting of METEOR coincided with that of the Checkmate 025 study which randomized similarly eligible patients to receive nivolumab or everolimus 10 mg daily...
March 2017: Current Treatment Options in Oncology
https://www.readbyqxmd.com/read/28281972/a-randomized-controlled-open-label-pilot-study-of-simvastatin-addition-to-whole-brain-radiation-therapy-in-patients-with-brain-metastases
#20
RANDOMIZED CONTROLLED TRIAL
Manal El-Hamamsy, Hesham Elwakil, Amr S Saad, May A Shawki
Statins have been reported to have a potential radiosensitizing effect that has not been evaluated in clinical trials. The aim of this study was to evaluate the efficacy and safety of simvastatin in addition to whole-brain radiation therapy (WBRT) in patients with brain metastases (BM). A prospective randomized, controlled, open-label pilot study was conducted on 50 Egyptian patients with BM who were randomly assigned to receive 30-Gy WBRT (control group: 25 patients) or 30 Gy WBRT + simvastatin 80 mg/day for the WBRT period (simvastatin group: 25 patients)...
October 27, 2016: Oncology Research
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